Folate biosynthesis (Bacillus subtilis)

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dihydrofolate reductase5,6,7,8-tetrahydrofolic acid4.1.3.384-Aminobenzoatedihydrofolate reductase2.5.1.15(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl trihydrogen diphosphateChorismatefolatePhenylalaninebiosynthese7,8-dihydropteroic acidDihydrofolic acid6.3.2.124-Amino-4-deoxychorismate6.3.2.172.6.1.85


Description

Pathway describe the folate synthesis.

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

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CompareRevisionActionTimeUserComment
118112view10:57, 24 May 2021EweitzModified title
105913view11:40, 16 August 2019MkutmonHMDB identifier normalization
87506view01:48, 25 July 2016AlexanderPicoOntology Term : 'classic metabolic pathway' added !
87505view01:48, 25 July 2016AlexanderPicoOntology Term : 'folate metabolic pathway' added !
72207view12:00, 27 October 2013EgonwAdded a missing metabolite identifier.
72206view11:59, 27 October 2013EgonwReplaced InChIs and an InChIKey with more traditional identifiers.
71450view19:15, 17 October 2013MaintBotAutomated update of data sources
70670view15:55, 24 August 2013EgonwMinor graphical improvements: larger boxes if things fell out, and new line in long IUPAC name.
69464view19:48, 8 July 2013EgonwExtending the folate biosynthesis pathway.
69463view19:34, 8 July 2013EgonwModified description
68420view18:40, 5 July 2013MaintBotUpdated to 2013 gpml schema
58400view22:07, 12 February 2013MaintBotModified categories
53528view19:02, 8 November 2012Egonw
53527view19:01, 8 November 2012EgonwHa, figured out how to do a reaction with the main reactants.
53526view18:38, 8 November 2012EgonwGrowing...
53508view10:51, 8 November 2012EgonwCorrect organism.
53507view10:40, 8 November 2012EgonwAdded a third metabolite
53506view10:23, 8 November 2012Egonw
53505view10:22, 8 November 2012EgonwNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
(2-amino-4-hydroxy-7,8-dihydropteridin- 6-yl)methyl trihydrogen diphosphateMetaboliteInChI=1S/C7H11N5O8P2/c8-7-11-5-4(6(13)12-7)10-3(1-9-5)2-19-22(17,18)20-21(14,15)16/h1-2H2,(H,17,18)(H2,14,15,16)(H4,8,9,11,12,13) (InChI)
2.5.1.15Protein2.5.1.15 (Enzyme Nomenclature)
2.6.1.85GeneProduct2.6.1.85 (Enzyme Nomenclature)
4-Amino-4-deoxychorismateMetabolite
4-AminobenzoateMetaboliteC00568 (KEGG Compound)
4.1.3.38Protein4.1.3.38 (Enzyme Nomenclature)
5,6,7,8-tetrahydrofolic acidMetaboliteMSTNYGQPCMXVAQ-KIYNQFGBSA-N (InChIKey)
6.3.2.12Protein6.3.2.12 (Enzyme Nomenclature)
6.3.2.17Protein6.3.2.17 (Enzyme Nomenclature)
7,8-dihydropteroic acidMetaboliteInChI=1S/C14H14N6O3/c15-14-19-11-10(12(21)20-14)18-9(6-17-11)5-16-8-3-1-7(2-4-8)13(22)23/h1-4,16H,5-6H2,(H,22,23)(H4,15,17,19,20,21) (InChI)
ChorismateMetaboliteHMDB12199 (HMDB)
Dihydrofolic acidMetaboliteHMDB01056 (HMDB)
Phenylalanine biosynthesePathway
dihydrofolate reductaseProtein1.5.1.3 (Enzyme Nomenclature)
folateMetaboliteHMDB00121 (HMDB)

Annotated Interactions

No annotated interactions

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