Regulation of actin cytoskeleton (Danio rerio)
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Stabilization
of actin
RTK
RAS
Actomyosin
assembly contraction
GPCR
RTK
Gene Expression
GPCR
RAS
Growth Factor (GF)
GF
Actin polymerization
Chemotatic factor
+p
PI3K
Actin polymerization
stress fiber
Lamellipodia
Filipodia
Focal complex
assembly
PI3K
?
Chemotactic factor
Actin
polymerization
-p
Focal adhesion
assembly
stress fiber
si:dkey-74f15.3
LPS
FGF2
msnb
ARPC5
mapk3
Apc2
f2
fgf14
zgc:153713
fgfr4
mylkb
ARHGEF1
SOS1
limk1
myl1
TMSB4X
FGF20
CFL1
arhgef7a
LOC442775
LOC100149843
csk
fn1
WASF1
pik3cb
PFN1
LOC792708
wasb
LOC558288
Adherens junction
pathway
egfra
ssh1b
msna
LOC100536317
mos
FGF6
iqgap1
pip4k2aa
crk
vcl
pik3cg
cfl2
si:ch211-197g15.13
cdc42l
ptk2.1
vil1l
fgf8a
braf
dock1
PIK3C2G
egf
itga1
chrm2a
nckap1
rac2
slc9a1
pak7
PAK3
gna12
DIAP3
myh10
fgd1
ROCK1
FGF9
DIAP1
zgc:153663
f2r
PIP2
actn1
ENAH
rras
MAP2K2
sos2
fgf5
Focal Adhesion
pathway
ACTG1
rras2
Focal Adhesion
pathway
pik3r2
PIP2
GNG12
pdgfra
FGF21
pip5k1ab
FGF22
wu:fc03h05
mapk6
LOC565130
INS1
PDGFA
LOC100330960
nras
pik3r3
zgc:92014
LOC557176
gsna
chrm5a
VAV1
rac1
gna13a
pip5k1bb
zgc:114164
chrm3a
BAIAP2
cyfip2
si:dkey-24l11.7
kras
vcl
chrm4a
ACTB
SSH3
RAC1P4
fgf4
FGF15
WASF2
zgc:86903
PIP3
pip4k2aa
FGF1
Acetylcholine
im:7150469
fgf17
LOC558288
PIK3CA
ACTB
ARPC5
pik3c3
GRLF1
mapk1
raf1b
rock2a
fgfr2
VIL2
bdkrb1
fgf10a
PDGFB
pik3r4
fgfr3
fgf7
PFN1
Bradykinin
fgf23
LOC555920
bcar1
fgf3
FGF18
FGF13
MAPK Signaling
pathway
CD14
fgfr1a
BAIAP2
PAK6
C11orf13
FGF11
pak2a
INS2
mapk4
fgf12a
pdgfrb
ACTG1
apc
ppp1r12a
pik3cd
fgf16
PIP5K2C
SSH2
map2k1
ACTB
ACTG1
pak1
LOC568935
RAC3
Description
http://www.genome.jp/kegg/pathway/hsa/hsa04810.html
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP51(r45278)
with a 66% conversion rate.
Try the New WikiPathways
View approved pathways at
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.
Quality Tags
Ontology Terms
Saving...
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Bibliography
No bibliography
History
View all...
Compare
Revision
Action
Time
User
Comment
116903
view
11:33, 15 May 2021
Eweitz
Modified title
72128
view
07:53, 25 October 2013
Mkutmon
added datasource to pathway data nodes
71535
view
19:23, 17 October 2013
MaintBot
Automated update of data sources
68684
view
05:44, 6 July 2013
MaintBot
Updated to 2013 gpml schema
47916
view
21:38, 18 April 2012
Khanspers
Removed redundant information
47915
view
21:37, 18 April 2012
Khanspers
Updating from human to fix xref duplication
40858
view
22:20, 1 March 2011
MaintBot
Removed redundant pathway information and comments
34239
view
21:40, 9 December 2009
MaintBot
Automatic update of empty xrefs
32340
view
13:34, 15 August 2009
MaintBot
Fixed text labels
31956
view
13:03, 14 August 2009
MaintBot
Fixed group labels
31386
view
20:44, 13 August 2009
MaintBot
Fixed text labels
31092
view
01:38, 30 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
ACTB
GeneProduct
ACTG1
GeneProduct
ARHGEF1
GeneProduct
ARPC5
GeneProduct
Acetylcholine
Metabolite
51-84-3 (CAS)
Adherens junction pathway
Pathway
Apc2
GeneProduct
BAIAP2
GeneProduct
Bradykinin
Metabolite
58-82-2 (CAS)
C11orf13
GeneProduct
CD14
GeneProduct
CFL1
GeneProduct
DIAP1
GeneProduct
DIAP3
GeneProduct
ENAH
GeneProduct
FGF1
GeneProduct
FGF11
GeneProduct
FGF13
GeneProduct
FGF15
GeneProduct
FGF18
GeneProduct
FGF2
GeneProduct
FGF20
GeneProduct
FGF21
GeneProduct
FGF22
GeneProduct
FGF6
GeneProduct
FGF9
GeneProduct
Focal Adhesion pathway
Pathway
WP306
GNG12
GeneProduct
GRLF1
GeneProduct
INS1
GeneProduct
INS2
GeneProduct
LOC100149843
GeneProduct
100149843 (Entrez Gene)
LOC100330960
GeneProduct
100330960 (Entrez Gene)
LOC100536317
GeneProduct
100536317 (Entrez Gene)
LOC442775
GeneProduct
LOC555920
GeneProduct
555920 (Entrez Gene)
LOC557176
GeneProduct
557176 (Entrez Gene)
LOC558288
GeneProduct
558288 (Entrez Gene)
LOC565130
GeneProduct
565130 (Entrez Gene)
LOC568935
GeneProduct
568935 (Entrez Gene)
LOC792708
GeneProduct
792708 (Entrez Gene)
LPS
Metabolite
C00338 (KEGG Compound)
MAP2K2
GeneProduct
MAPK Signaling pathway
Pathway
WP382
PAK3
GeneProduct
PAK6
GeneProduct
PDGFA
GeneProduct
PDGFB
GeneProduct
PFN1
GeneProduct
PIK3C2G
GeneProduct
PIK3CA
GeneProduct
PIP2
Metabolite
C04637 (KEGG Compound)
PIP3
Metabolite
C05981 (KEGG Compound)
PIP5K2C
GeneProduct
RAC1P4
GeneProduct
RAC3
GeneProduct
ROCK1
GeneProduct
SOS1
GeneProduct
SSH2
GeneProduct
SSH3
GeneProduct
TMSB4X
GeneProduct
VAV1
GeneProduct
VIL2
GeneProduct
WASF1
GeneProduct
WASF2
GeneProduct
actn1
GeneProduct
560400 (Entrez Gene)
apc
GeneProduct
386762 (Entrez Gene)
arhgef7a
GeneProduct
553493 (Entrez Gene)
bcar1
GeneProduct
568309 (Entrez Gene)
bdkrb1
GeneProduct
368199 (Entrez Gene)
braf
GeneProduct
403065 (Entrez Gene)
cdc42l
GeneProduct
793158 (Entrez Gene)
cfl2
GeneProduct
403001 (Entrez Gene)
chrm2a
GeneProduct
352938 (Entrez Gene)
chrm3a
GeneProduct
571679 (Entrez Gene)
chrm4a
GeneProduct
100150701 (Entrez Gene)
chrm5a
GeneProduct
553978 (Entrez Gene)
crk
GeneProduct
445234 (Entrez Gene)
csk
GeneProduct
556454 (Entrez Gene)
cyfip2
GeneProduct
100002872 (Entrez Gene)
dock1
GeneProduct
572187 (Entrez Gene)
egf
GeneProduct
403045 (Entrez Gene)
egfra
GeneProduct
378478 (Entrez Gene)
f2
GeneProduct
325881 (Entrez Gene)
f2r
GeneProduct
558477 (Entrez Gene)
fgd1
GeneProduct
560305 (Entrez Gene)
fgf10a
GeneProduct
359830 (Entrez Gene)
fgf12a
GeneProduct
777735 (Entrez Gene)
fgf14
GeneProduct
497642 (Entrez Gene)
fgf16
GeneProduct
692065 (Entrez Gene)
fgf17
GeneProduct
407737 (Entrez Gene)
fgf23
GeneProduct
494456 (Entrez Gene)
fgf3
GeneProduct
30549 (Entrez Gene)
fgf4
GeneProduct
570435 (Entrez Gene)
fgf5
GeneProduct
494454 (Entrez Gene)
fgf7
GeneProduct
493181 (Entrez Gene)
fgf8a
GeneProduct
30538 (Entrez Gene)
fgfr1a
GeneProduct
30705 (Entrez Gene)
fgfr2
GeneProduct
352940 (Entrez Gene)
fgfr3
GeneProduct
58129 (Entrez Gene)
fgfr4
GeneProduct
100000160 (Entrez Gene)
fn1
GeneProduct
100005469 (Entrez Gene)
gna12
GeneProduct
503589 (Entrez Gene)
gna13a
GeneProduct
326825 (Entrez Gene)
gsna
GeneProduct
321099 (Entrez Gene)
im:7150469
GeneProduct
567938 (Entrez Gene)
iqgap1
GeneProduct
100002928 (Entrez Gene)
itga1
GeneProduct
570868 (Entrez Gene)
kras
GeneProduct
445289 (Entrez Gene)
limk1
GeneProduct
735292 (Entrez Gene)
map2k1
GeneProduct
406728 (Entrez Gene)
mapk1
GeneProduct
360144 (Entrez Gene)
mapk3
GeneProduct
399480 (Entrez Gene)
mapk4
GeneProduct
406782 (Entrez Gene)
mapk6
GeneProduct
565830 (Entrez Gene)
mos
GeneProduct
795517 (Entrez Gene)
msna
GeneProduct
286739 (Entrez Gene)
msnb
GeneProduct
553434 (Entrez Gene)
myh10
GeneProduct
555454 (Entrez Gene)
myl1
GeneProduct
336165 (Entrez Gene)
mylkb
GeneProduct
492576 (Entrez Gene)
nckap1
GeneProduct
561894 (Entrez Gene)
nras
GeneProduct
30380 (Entrez Gene)
pak1
GeneProduct
373103 (Entrez Gene)
pak2a
GeneProduct
266749 (Entrez Gene)
pak7
GeneProduct
405898 (Entrez Gene)
pdgfra
GeneProduct
30745 (Entrez Gene)
pdgfrb
GeneProduct
559529 (Entrez Gene)
pik3c3
GeneProduct
548346 (Entrez Gene)
pik3cb
GeneProduct
100002263 (Entrez Gene)
pik3cd
GeneProduct
394174 (Entrez Gene)
pik3cg
GeneProduct
406598 (Entrez Gene)
pik3r2
GeneProduct
404211 (Entrez Gene)
pik3r3
GeneProduct
100000252 (Entrez Gene)
pik3r4
GeneProduct
564088 (Entrez Gene)
pip4k2aa
GeneProduct
560360 (Entrez Gene)
pip5k1ab
GeneProduct
492549 (Entrez Gene)
pip5k1bb
GeneProduct
447840 (Entrez Gene)
ppp1r12a
GeneProduct
445393 (Entrez Gene)
ptk2.1
GeneProduct
142986 (Entrez Gene)
rac1
GeneProduct
327204 (Entrez Gene)
rac2
GeneProduct
415151 (Entrez Gene)
raf1b
GeneProduct
557109 (Entrez Gene)
rock2a
GeneProduct
317747 (Entrez Gene)
rras2
GeneProduct
550513 (Entrez Gene)
rras
GeneProduct
449660 (Entrez Gene)
si:ch211-197g15.13
GeneProduct
798876 (Entrez Gene)
si:dkey-24l11.7
GeneProduct
571356 (Entrez Gene)
si:dkey-74f15.3
GeneProduct
559017 (Entrez Gene)
slc9a1
GeneProduct
795135 (Entrez Gene)
sos2
GeneProduct
561670 (Entrez Gene)
ssh1b
GeneProduct
567479 (Entrez Gene)
vcl
GeneProduct
552980 (Entrez Gene)
vil1l
GeneProduct
393207 (Entrez Gene)
wasb
GeneProduct
335158 (Entrez Gene)
wu:fc03h05
GeneProduct
323588 (Entrez Gene)
zgc:114164
GeneProduct
574004 (Entrez Gene)
zgc:153663
GeneProduct
767646 (Entrez Gene)
zgc:153713
GeneProduct
751630 (Entrez Gene)
zgc:86903
GeneProduct
415187 (Entrez Gene)
zgc:92014
GeneProduct
431769 (Entrez Gene)
Annotated Interactions
No annotated interactions
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View approved pathways at the new wikipathways.org.Quality Tags
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External references
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Annotated Interactions
No annotated interactions