Apoptotic execution phase (Homo sapiens)

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522451521, 412549243829, 362416, 3539, 40, 4517136524, 276844104750222613287429823, 37, 433114, 482012, 5134630443219496463324918endoplasmic reticulum membranenucleoplasmcytosolmitochondrial matrixDFF cleaved DNAPAK2vimentin (2-429 fragment)BAP31 fragment (165-237)caspase 3/caspase 7Lamin B1 fragment (232-586)PKC-delta (fragment 1-329)active caspase-3DFF40 homodimer/homooligomerHIP-55 fragment (1-361)Desmoglein 2 (70 Kd fragment)Claspin fragment(1073-1332)spectrin alpha chain/alpha-II-Fodrin fragment (1-1185)DFF40/DFFB/CADDFFA/DFF1/DFF45farnesyltransferase/geranyl-geranyltransferase subunit alpha fragment (1-59)Plectin 1DFF45:DFF40 complexactive caspase-7Satb1MST3 fragment (1-313)farnesyltransferase/geranyl-geranyltransferase subunit alpha fragment (60-379)proteolytically cleaved ZO-2Acinus fragment (1-1093)GAS2 (280-313)Adducin alphaunidentified caspase acting on ZO-1Etkcaspase-3-cleaved DFF45 (117,224):DFF40 complexPlectin 1 fragment (1-2395)spectrin alpha chain/alpha-II-Fodrin fragment (1186-2472)Caspase-8 dimerMST3 fragment (314-443)Occludin fragment (321-522)DFF:associated with the importin-alpha:importin-beta complexMASK fragment (306-416)spectrin alpha chain, brain/alpha II fodrinHMGB1/HMGB2active caspase 3active caspase-6APC fragment (1-777)ZO-1Caspase-8 dimerAlpha adducin fragment (1-633)APC fragment (778-2843)farnesyltransferase/geranyl-geranyltransferase subunit alphavimentin (260-466 fragment)BAP31 fragment (2-164)Acinus fragment (1094-1341)Protein kinase C, theta type fragment (355-706)Drp1Caspase cleaved DFF45 (117)HIP-55 fragment (362-431)Gelsolin (404-782 fragment)unidentified caspase acting on OccludinSatb1 (fragment (255-763)Alpha adducin fragment (634-737)ADPClaspinGAS2 (1-279)Desmoglein 1Lamin B1unidentified caspase acting on DesmoplakinGelsolin (27-403 fragment)ATPDesmoglein 1 fragment (50-888)Occludin fragment (1-320)DesmoplakinDesmoglein 3Etk fragment (243-675)Tau fragment (422-758)active caspase-3APCHMGB1/HMGB2- bound chromatinDFF45 fragment (118-224)DFF40 associated with chromatinC-IAP1(373-618 )DFF40/DFFB/CADLamin A fragment (1-230)Protein kinase C, theta type fragment (1-354)Lamin ADFF45:DFF40 complexFADK1vimentin (86-466 fragment)Etk fragment (1-242)importin-alpha:importin-betac-IAP1Rock1 fragment (1114-1354)partially autophosphorylated full length PAK-2 (inactive)proteolytically cleaved Plakophilin 1Desmoglein 1 fragment (889-1049)DFF:associated with the importin-alpha:importin-beta complexSatb1 (fragment (1-254)partially auto-phosphorylated PAK-2 fragment (1-212)ADPunidentified caspase acting on ZO-2GelsolinDFF40 homodimerRock1PAK-2p34ATPactive caspase-7vimentin (430-466 fragment)MST3 fragment (1-313)unidentified caspaseEpithelial-cadherin precursor fragment (155-750)FADK 1 fragment (1-772)ZO-2unidentified caspase acting on Plakophilin 1Rock1 fragment (1-1113)Caspase-cleaved ZO-1 fragmentsvimentin (2-466 fragment)Lamin A (fragment 231-664)FADK 1 fragment (773-1052)Desmoglein 2BAP31C-IAP1(1-372)beta-catenin-1(116-376)Plectin 1 fragment (2396-4684)Plakophilin 1Desmoglein 3 fragment (782-999)Tau fragment (2-421)MASK fragment (1-305)Drp1Epithelial-cadherin precursor fragment (751-882)MASKactive caspase-6beta-catenin-1(1-115)beta-cateninvimentin (2-259 fragment)Desmoglein 3 fragment (50-781)GAS2AcinusDFF45 fragment (225-331)TauProtein kinase C, theta typeDFF45 fragment (1-117)Lamin B1 (fragment 1-231)Cadherin-1proteolytically cleaved Desmoplakinphospho-PAK-2p34 (Thr 402)PKC-deltaClaspin fragment (1-1072)OccludinHistone H1 bound chromatin DNAMST3phospho-PAK-2p34 (Thr 402)HIP-55DNAPKC-delta fragment (330-676)BAP31 fragment (238-246)vimentin (2-85 fragment)1121, 414, 27


Description

In the execution phase of apoptosis, effector caspases cleave vital cellular proteins leading to the morphological changes that characterize apoptosis. These changes include destruction of the nucleus and other organelles, DNA fragmentation, chromatin condensation, cell shrinkage and cell detachment and membrane blebbing (reviewed in Fischer et al., 2003).

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Ontology Terms

 

Bibliography

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  1. Kalinowska-Herok M, Widłak P.; ''High mobility group proteins stimulate DNA cleavage by apoptotic endonuclease DFF40/CAD due to HMG-box interactions with DNA.''; PubMed Europe PMC Scholia
  2. Thomsen ND, Koerber JT, Wells JA.; ''Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation.''; PubMed Europe PMC Scholia
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  6. Cirillo N, Lanza M, De Rosa A, Cammarota M, La Gatta A, Gombos F, Lanza A.; ''The most widespread desmosomal cadherin, desmoglein 2, is a novel target of caspase 3-mediated apoptotic machinery.''; PubMed Europe PMC Scholia
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  20. Webb SJ, Nicholson D, Bubb VJ, Wyllie AH.; ''Caspase-mediated cleavage of APC results in an amino-terminal fragment with an intact armadillo repeat domain.''; PubMed Europe PMC Scholia
  21. Widlak P, Li P, Wang X, Garrard WT.; ''Cleavage preferences of the apoptotic endonuclease DFF40 (caspase-activated DNase or nuclease) on naked DNA and chromatin substrates.''; PubMed Europe PMC Scholia
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  23. Chang J, Xie M, Shah VR, Schneider MD, Entman ML, Wei L, Schwartz RJ.; ''Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis.''; PubMed Europe PMC Scholia
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  26. Clarke CA, Bennett LN, Clarke PR.; ''Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway.''; PubMed Europe PMC Scholia
  27. van de Water B, Tijdens IB, Verbrugge A, Huigsloot M, Dihal AA, Stevens JL, Jaken S, Mulder GJ.; ''Cleavage of the actin-capping protein alpha -adducin at Asp-Asp-Ser-Asp633-Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells.''; PubMed Europe PMC Scholia
  28. Weiske J, Schöneberg T, Schröder W, Hatzfeld M, Tauber R, Huber O.; ''The fate of desmosomal proteins in apoptotic cells.''; PubMed Europe PMC Scholia
  29. Dusek RL, Getsios S, Chen F, Park JK, Amargo EV, Cryns VL, Green KJ.; ''The differentiation-dependent desmosomal cadherin desmoglein 1 is a novel caspase-3 target that regulates apoptosis in keratinocytes.''; PubMed Europe PMC Scholia
  30. Sgorbissa A, Benetti R, Marzinotto S, Schneider C, Brancolini C.; ''Caspase-3 and caspase-7 but not caspase-6 cleave Gas2 in vitro: implications for microfilament reorganization during apoptosis.''; PubMed Europe PMC Scholia
  31. Chandra D, Choy G, Deng X, Bhatia B, Daniel P, Tang DG.; ''Association of active caspase 8 with the mitochondrial membrane during apoptosis: potential roles in cleaving BAP31 and caspase 3 and mediating mitochondrion-endoplasmic reticulum cross talk in etoposide-induced cell death.''; PubMed Europe PMC Scholia
  32. Browne SJ, MacFarlane M, Cohen GM, Paraskeva C.; ''The adenomatous polyposis coli protein and retinoblastoma protein are cleaved early in apoptosis and are potential substrates for caspases.''; PubMed Europe PMC Scholia
  33. Warby SC, Doty CN, Graham RK, Carroll JB, Yang YZ, Singaraja RR, Overall CM, Hayden MR.; ''Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus.''; PubMed Europe PMC Scholia
  34. Liu X, Zou H, Slaughter C, Wang X.; ''DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis.''; PubMed Europe PMC Scholia
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  36. Chai J, Wu Q, Shiozaki E, Srinivasula SM, Alnemri ES, Shi Y.; ''Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding.''; PubMed Europe PMC Scholia
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  38. Huang CY, Wu YM, Hsu CY, Lee WS, Lai MD, Lu TJ, Huang CL, Leu TH, Shih HM, Fang HI, Robinson DR, Kung HJ, Yuan CJ.; ''Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis.''; PubMed Europe PMC Scholia
  39. Fischer U, Jänicke RU, Schulze-Osthoff K.; ''Many cuts to ruin: a comprehensive update of caspase substrates.''; PubMed Europe PMC Scholia
  40. Sahara S, Aoto M, Eguchi Y, Imamoto N, Yoneda Y, Tsujimoto Y.; ''Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation.''; PubMed Europe PMC Scholia
  41. Hanus J, Kalinowska-Herok M, Widlak P.; ''The major apoptotic endonuclease DFF40/CAD is a deoxyribose-specific and double-strand-specific enzyme.''; PubMed Europe PMC Scholia
  42. Clem RJ, Sheu TT, Richter BW, He WW, Thornberry NA, Duckett CS, Hardwick JM.; ''c-IAP1 is cleaved by caspases to produce a proapoptotic C-terminal fragment.''; PubMed Europe PMC Scholia
  43. Chen YR, Kori R, John B, Tan TH.; ''Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis.''; PubMed Europe PMC Scholia
  44. Shi Y.; ''Mechanisms of caspase activation and inhibition during apoptosis.''; PubMed Europe PMC Scholia
  45. Steinhusen U, Badock V, Bauer A, Behrens J, Wittman-Liebold B, Dörken B, Bommert K.; ''Apoptosis-induced cleavage of beta-catenin by caspase-3 results in proteolytic fragments with reduced transactivation potential.''; PubMed Europe PMC Scholia
  46. Zhivotovsky B, Samali A, Gahm A, Orrenius S.; ''Caspases: their intracellular localization and translocation during apoptosis.''; PubMed Europe PMC Scholia
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  48. Rao L, Perez D, White E.; ''Lamin proteolysis facilitates nuclear events during apoptosis.''; PubMed Europe PMC Scholia
  49. Dan I, Ong SE, Watanabe NM, Blagoev B, Nielsen MM, Kajikawa E, Kristiansen TZ, Mann M, Pandey A.; ''Cloning of MASK, a novel member of the mammalian germinal center kinase III subfamily, with apoptosis-inducing properties.''; PubMed Europe PMC Scholia
  50. Breckenridge DG, Stojanovic M, Marcellus RC, Shore GC.; ''Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol.''; PubMed Europe PMC Scholia
  51. Wu YM, Huang CL, Kung HJ, Huang CY.; ''Proteolytic activation of ETK/Bmx tyrosine kinase by caspases.''; PubMed Europe PMC Scholia
  52. Galande S, Dickinson LA, Mian IS, Sikorska M, Kohwi-Shigematsu T.; ''SATB1 cleavage by caspase 6 disrupts PDZ domain-mediated dimerization, causing detachment from chromatin early in T-cell apoptosis.''; PubMed Europe PMC Scholia
  53. Kim KW, Chung HH, Chung CW, Kim IK, Miura M, Wang S, Zhu H, Moon KD, Rha GB, Park JH, Jo DG, Woo HN, Song YH, Kim BJ, Yuan J, Jung YK.; ''Inactivation of farnesyltransferase and geranylgeranyltransferase I by caspase-3: cleavage of the common alpha subunit during apoptosis.''; PubMed Europe PMC Scholia
  54. Stegh AH, Herrmann H, Lampel S, Weisenberger D, Andrä K, Seper M, Wiche G, Krammer PH, Peter ME.; ''Identification of the cytolinker plectin as a major early in vivo substrate for caspase 8 during CD95- and tumor necrosis factor receptor-mediated apoptosis.''; PubMed Europe PMC Scholia
  55. Kothakota S, Azuma T, Reinhard C, Klippel A, Tang J, Chu K, McGarry TJ, Kirschner MW, Koths K, Kwiatkowski DJ, Williams LT.; ''Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis.''; PubMed Europe PMC Scholia
  56. Watt W, Koeplinger KA, Mildner AM, Heinrikson RL, Tomasselli AG, Watenpaugh KD.; ''The atomic-resolution structure of human caspase-8, a key activator of apoptosis.''; PubMed Europe PMC Scholia
  57. Geng YJ, Azuma T, Tang JX, Hartwig JH, Muszynski M, Wu Q, Libby P, Kwiatkowski DJ.; ''Caspase-3-induced gelsolin fragmentation contributes to actin cytoskeletal collapse, nucleolysis, and apoptosis of vascular smooth muscle cells exposed to proinflammatory cytokines.''; PubMed Europe PMC Scholia
  58. Ghayur T, Hugunin M, Talanian RV, Ratnofsky S, Quinlan C, Emoto Y, Pandey P, Datta R, Huang Y, Kharbanda S, Allen H, Kamen R, Wong W, Kufe D.; ''Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosis.''; PubMed Europe PMC Scholia
  59. Turowec JP, Zukowski SA, Knight JD, Smalley DM, Graves LM, Johnson GL, Li SS, Lajoie GA, Litchfield DW.; ''An unbiased proteomic screen reveals caspase cleavage is positively and negatively regulated by substrate phosphorylation.''; PubMed Europe PMC Scholia

History

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114845view16:34, 25 January 2021ReactomeTeamReactome version 75
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99588view14:58, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
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93810view13:37, 16 August 2017ReactomeTeamreactome version 61
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86436view09:18, 11 July 2016ReactomeTeamreactome version 56
83236view10:27, 18 November 2015ReactomeTeamVersion54
81341view12:51, 21 August 2015ReactomeTeamVersion53
76813view08:03, 17 July 2014ReactomeTeamFixed remaining interactions
76517view11:44, 16 July 2014ReactomeTeamFixed remaining interactions
75850view09:50, 11 June 2014ReactomeTeamRe-fixing comment source
75550view10:33, 10 June 2014ReactomeTeamReactome 48 Update
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74904view12:27, 8 May 2014AnweshaChanged comment source from Wikipathways to WikiPathways
74549view08:35, 30 April 2014ReactomeTeamReactome46
71704view19:56, 17 October 2013MaintBotUpdated data sources
44958view12:40, 6 October 2011MartijnVanIerselOntology Term : 'apoptotic cell death pathway' added !
42155view23:16, 4 March 2011MaintBotModified categories
39997view00:18, 22 January 2011AlexanderPicoreset uniprot
39810view05:50, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADP Metabolite16761 (ChEBI)
APC ProteinREACT_10434 (Reactome)
APC fragment (1-

777)

ProteinREACT_12313 (Reactome)
APC fragment (778-

2843)

ProteinREACT_12296 (Reactome)
ATP Metabolite15422 (ChEBI)
Acinus ProteinQ9UKV3 (Uniprot-TrEMBL)
Acinus fragment

(1094-1341)

ProteinQ9UKV3 (Uniprot-TrEMBL)
Acinus fragment (1-

1093)

ProteinQ9UKV3 (Uniprot-TrEMBL)
Adducin alpha ProteinP35611 (Uniprot-TrEMBL)
Alpha adducin

fragment (634-737)

ProteinP35611 (Uniprot-TrEMBL)
Alpha adducin

fragment (1-633)

ProteinP35611 (Uniprot-TrEMBL)
BAP31 ProteinP51572 (Uniprot-TrEMBL)
BAP31 fragment

(165-237)

ProteinP51572 (Uniprot-TrEMBL)
BAP31 fragment

(2-164)

ProteinP51572 (Uniprot-TrEMBL)
BAP31 fragment

(238-246)

ProteinP51572 (Uniprot-TrEMBL)
C-IAP1(1-372) ProteinQ13490 (Uniprot-TrEMBL)
C-IAP1(373-618 ) ProteinQ13490 (Uniprot-TrEMBL)
Cadherin-1 ProteinP12830 (Uniprot-TrEMBL)
Caspase cleaved

DFF45 (117)

ComplexREACT_13101 (Reactome)
Caspase-8 dimer ComplexREACT_13946 (Reactome)
Caspase-8 dimer ComplexREACT_4185 (Reactome)
Caspase-cleaved

ZO-1 fragments

ProteinQ07157-1 (Uniprot-TrEMBL)
Claspin ProteinQ9HAW4 (Uniprot-TrEMBL)
Claspin fragment

(1073-1332)

ProteinQ9HAW4 (Uniprot-TrEMBL)
Claspin fragment (1-

1072)

ProteinQ9HAW4 (Uniprot-TrEMBL)
DFF cleaved DNA ComplexREACT_14657 (Reactome)
DFF40

homodimer/homoolig omer

REACT_14397 (Reactome)
DFF40 associated

with chromatin

ComplexREACT_14402 (Reactome)
DFF40 homodimer ComplexREACT_14622 (Reactome)
DFF40/DFFB/CAD ProteinO76075 (Uniprot-TrEMBL)
DFF45 fragment

(118-224)

ProteinO00273 (Uniprot-TrEMBL)
DFF45 fragment

(225-331)

ProteinO00273 (Uniprot-TrEMBL)
DFF45 fragment (1-

117)

ProteinO00273 (Uniprot-TrEMBL)
DFF45:DFF40

complex

ComplexREACT_12695 (Reactome)
DFF45:DFF40

complex

ComplexREACT_14626 (Reactome)
DFF:associated with

the importin-alpha: importin-beta complex

ComplexREACT_14003 (Reactome)
DFF:associated with

the importin-alpha: importin-beta complex

ComplexREACT_14680 (Reactome)
DFFA/DFF1/DFF45 ProteinO00273 (Uniprot-TrEMBL)
DNA REACT_3913 (Reactome)
Desmoglein 1 ProteinQ02413 (Uniprot-TrEMBL)
Desmoglein 1

fragment (50-888)

ProteinQ02413 (Uniprot-TrEMBL)
Desmoglein 1

fragment (889-1049)

ProteinQ02413 (Uniprot-TrEMBL)
Desmoglein 2 ProteinQ14126 (Uniprot-TrEMBL)
Desmoglein 2 (70

Kd fragment)

ProteinQ14126 (Uniprot-TrEMBL) The caspase 3-mediated proteolytic processing of full-length Dsg2, the most widespread desmosomal cadherin, results in disappearance of Dsg2 from the cell surface and appearance of a 70-kDa fragment in the cytosol. Loss of Dsg2 from the cell surface may contribute to the progressive loss of intercellular adhesion strength during apoptosis (Cirillo et al., 2008)
Desmoglein 3 Protein
Desmoglein 3

fragment (782-999)

ProteinP32926 (Uniprot-TrEMBL)
Desmoglein 3

fragment (50-781)

ProteinP32926 (Uniprot-TrEMBL)
Desmoplakin Protein
Drp1 ProteinO00429 (Uniprot-TrEMBL)
Epithelial-cadherin

precursor fragment (155-750)

ProteinP12830 (Uniprot-TrEMBL)
Epithelial-cadherin

precursor fragment (751-882)

ProteinP12830 (Uniprot-TrEMBL)
Etk ProteinP51813 (Uniprot-TrEMBL)
Etk fragment (1-242) ProteinP51813 (Uniprot-TrEMBL)
Etk fragment (243-

675)

ProteinP51813 (Uniprot-TrEMBL)
FADK 1 fragment

(773-1052)

ProteinQ05397 (Uniprot-TrEMBL)
FADK 1 fragment (1-

772)

ProteinQ05397 (Uniprot-TrEMBL)
FADK1 Protein
GAS2 (1-279) ProteinO43903 (Uniprot-TrEMBL)
GAS2 (280-313) ProteinO43903 (Uniprot-TrEMBL)
GAS2ProteinO43903 (Uniprot-TrEMBL)
Gelsolin ProteinP06396 (Uniprot-TrEMBL)
Gelsolin (27-403

fragment)

ProteinP06396 (Uniprot-TrEMBL)
Gelsolin (404-782

fragment)

ProteinP06396 (Uniprot-TrEMBL)
HIP-55 ProteinQ9UJU6 (Uniprot-TrEMBL)
HIP-55 fragment

(1-361)

ProteinQ9UJU6 (Uniprot-TrEMBL)
HIP-55 fragment

(362-431)

ProteinQ9UJU6 (Uniprot-TrEMBL)
HMGB1/HMGB2 ProteinREACT_14288 (Reactome)
HMGB1/HMGB2-

bound chromatin

ComplexREACT_14370 (Reactome)
Histone H1 bound

chromatin DNA

ComplexREACT_14129 (Reactome)
Lamin A ProteinP02545-1 (Uniprot-TrEMBL)
Lamin A (fragment

231-664)

ProteinP02545-1 (Uniprot-TrEMBL)
Lamin A fragment (1-

230)

ProteinP02545-1 (Uniprot-TrEMBL)
Lamin B1 ProteinP20700 (Uniprot-TrEMBL)
Lamin B1 (fragment

1-231)

ProteinP20700 (Uniprot-TrEMBL)
Lamin B1 fragment

(232-586)

ProteinP20700 (Uniprot-TrEMBL)
MASK ProteinQ9P289 (Uniprot-TrEMBL)
MASK fragment (1-305) ProteinQ9P289 (Uniprot-TrEMBL)
MASK fragment (306-

416)

ProteinQ9P289 (Uniprot-TrEMBL)
MST3 ProteinQ9Y6E0 (Uniprot-TrEMBL)
MST3

fragment (1-313)

ProteinQ9Y6E0 (Uniprot-TrEMBL)
MST3 fragment (1-

313)

ProteinQ9Y6E0 (Uniprot-TrEMBL)
MST3 fragment (314-

443)

ProteinQ9Y6E0 (Uniprot-TrEMBL)
Occludin ProteinQ16625 (Uniprot-TrEMBL)
Occludin fragment

(1-320)

ProteinQ16625 (Uniprot-TrEMBL)
Occludin fragment

(321-522)

ProteinQ16625 (Uniprot-TrEMBL)
PAK-2p34 ProteinQ13177 (Uniprot-TrEMBL)
PAK2 ProteinQ13177 (Uniprot-TrEMBL)
PKC-delta ProteinQ05655 (Uniprot-TrEMBL)
PKC-delta fragment

(330-676)

ProteinQ05655 (Uniprot-TrEMBL)
PKC-delta (fragment

1-329)

ProteinQ05655 (Uniprot-TrEMBL)
Plakophilin 1 ProteinQ13835 (Uniprot-TrEMBL)
Plectin 1 ProteinQ15149 (Uniprot-TrEMBL)
Plectin 1 fragment

(2396-4684)

ProteinQ15149 (Uniprot-TrEMBL)
Plectin 1 fragment (1-

2395)

ProteinQ15149 (Uniprot-TrEMBL)
Protein kinase C,

theta type

ProteinQ04759 (Uniprot-TrEMBL)
Protein kinase C,

theta type fragment (1-354)

ProteinQ04759 (Uniprot-TrEMBL)
Protein kinase C,

theta type fragment (355-706)

ProteinQ04759 (Uniprot-TrEMBL)
Rock1 ProteinQ13464 (Uniprot-TrEMBL)
Rock1 fragment

(1114-1354)

ProteinQ13464 (Uniprot-TrEMBL)
Rock1 fragment (1-

1113)

ProteinQ13464 (Uniprot-TrEMBL)
Satb1 ProteinQ01826 (Uniprot-TrEMBL)
Satb1 (fragment

(1-254)

ProteinQ01826 (Uniprot-TrEMBL)
Satb1 (fragment

(255-763)

ProteinQ01826 (Uniprot-TrEMBL)
Tau ProteinP10636 (Uniprot-TrEMBL)
Tau fragment (2-

421)

ProteinP10636 (Uniprot-TrEMBL)
Tau fragment (422-

758)

ProteinP10636 (Uniprot-TrEMBL)
ZO-1 Protein
ZO-2 ProteinQ9UDY2 (Uniprot-TrEMBL)
active caspase 3 ComplexREACT_12262 (Reactome)
active caspase-3 ComplexREACT_13159 (Reactome)
active caspase-3 ComplexREACT_2467 (Reactome)
active caspase-6 ComplexREACT_14257 (Reactome)
active caspase-6 ComplexREACT_14343 (Reactome)
active caspase-7 ComplexREACT_14263 (Reactome)
active caspase-7 ComplexREACT_3366 (Reactome)
beta-catenin ProteinREACT_10304 (Reactome)
beta-catenin-1(1-

115)

ProteinP35222-1 (Uniprot-TrEMBL)
beta-catenin-1(116-

376)

ProteinP35222-1 (Uniprot-TrEMBL)
c-IAP1 ProteinQ13490 (Uniprot-TrEMBL)
caspase 3/caspase 7 REACT_12368 (Reactome)
caspase-3-cleaved

DFF45 (117,224): DFF40 complex

ComplexREACT_13244 (Reactome)
farnesyltransferase/g

eranyl- geranyltransferase subunit alpha

ProteinP49354 (Uniprot-TrEMBL)
farnesyltransferase/g

eranyl- geranyltransferase subunit alpha fragment (1-59)

ProteinP49354 (Uniprot-TrEMBL)
farnesyltransferase/g

eranyl- geranyltransferase subunit alpha fragment (60-379)

ProteinP49354 (Uniprot-TrEMBL)
importin-alpha:

importin-beta

ComplexREACT_13986 (Reactome)
partially

autophosphorylated full length PAK-2 (inactive)

ProteinQ13177 (Uniprot-TrEMBL)
partially auto-

phosphorylated PAK-2 fragment (1-212)

ProteinQ13177 (Uniprot-TrEMBL)
phospho-PAK-2p34

(Thr 402)

ProteinQ13177 (Uniprot-TrEMBL)
proteolytically

cleaved Desmoplakin

ProteinP15924 (Uniprot-TrEMBL)
proteolytically

cleaved Plakophilin 1

ProteinQ13835 (Uniprot-TrEMBL)
proteolytically

cleaved ZO-2

ProteinQ9UDY2 (Uniprot-TrEMBL)
spectrin alpha

chain/alpha-II-Fodrin fragment (1-1185)

ProteinQ13813 (Uniprot-TrEMBL)
spectrin alpha

chain/alpha-II-Fodrin fragment (1186- 2472)

ProteinQ13813 (Uniprot-TrEMBL)
spectrin alpha chain,

brain/alpha II fodrin

ProteinQ13813 (Uniprot-TrEMBL)
unidentified caspase REACT_14138 (Reactome)
unidentified caspase

acting on Desmoplakin

REACT_21697 (Reactome)
unidentified caspase

acting on Occludin

REACT_21584 (Reactome)
unidentified caspase

acting on Plakophilin 1

REACT_21872 (Reactome)
unidentified caspase

acting on ZO-1

REACT_22050 (Reactome)
unidentified caspase

acting on ZO-2

REACT_22003 (Reactome)
vimentin (2-259

fragment)

ProteinP08670 (Uniprot-TrEMBL)
vimentin (2-429

fragment)

ProteinP08670 (Uniprot-TrEMBL)
vimentin (2-466

fragment)

ProteinP08670 (Uniprot-TrEMBL)
vimentin (2-85

fragment)

ProteinP08670 (Uniprot-TrEMBL)
vimentin (260-466

fragment)

ProteinP08670 (Uniprot-TrEMBL)
vimentin (430-466

fragment)

ProteinP08670 (Uniprot-TrEMBL)
vimentin (86-466

fragment)

ProteinP08670 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1784"
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