Transcription initiation by sigma factors (Mycobacterium tuberculosis)
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Description
Sigma factors are components of the RNA polymerase complex that are responsible for binding to the RNA polymerase complex, promoter recognition and separating DNA strands. The number of sigma factors is extremely diverse between bacteria, ranging from three in Helicobacter pylori to 63 in Streptomyces coelicolor. M. tuberculosis possesses 13 sigma factors, 10 of which are from the ECF sub-family, enabling this bacterium to cope with various environmental conditions
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- Song T, Song SE, Raman S, Anaya M, Husson RN; ''Critical role of a single position in the -35 element for promoter recognition by Mycobacterium tuberculosis SigE and SigH.''; J Bacteriol, 2008 PubMed Europe PMC Scholia
- Calamita H, Ko C, Tyagi S, Yoshimatsu T, Morrison NE, Bishai WR; ''The Mycobacterium tuberculosis SigD sigma factor controls the expression of ribosome-associated gene products in stationary phase and is required for full virulence.''; Cell Microbiol, 2005 PubMed Europe PMC Scholia
- Manganelli R, Voskuil MI, Schoolnik GK, Smith I; ''The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages.''; Mol Microbiol, 2001 PubMed Europe PMC Scholia
- Williams EP, Lee JH, Bishai WR, Colantuoni C, Karakousis PC; ''Mycobacterium tuberculosis SigF regulates genes encoding cell wall-associated proteins and directly regulates the transcriptional regulatory gene phoY1.''; J Bacteriol, 2007 PubMed Europe PMC Scholia
- Beaucher J, Rodrigue S, Jacques PE, Smith I, Brzezinski R, Gaudreau L; ''Novel Mycobacterium tuberculosis anti-sigma factor antagonists control sigmaF activity by distinct mechanisms.''; Mol Microbiol, 2002 PubMed Europe PMC Scholia
- Collins DM, Kawakami RP, de Lisle GW, Pascopella L, Bloom BR, Jacobs WR Jr; ''Mutation of the principal sigma factor causes loss of virulence in a strain of the Mycobacterium tuberculosis complex.''; Proc Natl Acad Sci U S A, 1995 PubMed Europe PMC Scholia
- Datta P, Shi L, Bibi N, Balázsi G, Gennaro ML; ''Regulation of central metabolism genes of Mycobacterium tuberculosis by parallel feed-forward loops controlled by sigma factor E (σ(E)).''; J Bacteriol, 2011 PubMed Europe PMC Scholia
- Manganelli R, Fattorini L, Tan D, Iona E, Orefici G, Altavilla G, Cusatelli P, Smith I; ''The extra cytoplasmic function sigma factor sigma(E) is essential for Mycobacterium tuberculosis virulence in mice.''; Infect Immun, 2004 PubMed Europe PMC Scholia
- Waagmeester A, Thompson J, Reyrat JM; ''Identifying sigma factors in Mycobacterium smegmatis by comparative genomic analysis.''; Trends Microbiol, 2005 PubMed Europe PMC Scholia
- Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG; ''Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.''; Nature, 1998 PubMed Europe PMC Scholia
- Manganelli R, Dubnau E, Tyagi S, Kramer FR, Smith I; ''Differential expression of 10 sigma factor genes in Mycobacterium tuberculosis.''; Mol Microbiol, 1999 PubMed Europe PMC Scholia
- Sassetti CM, Boyd DH, Rubin EJ; ''Genes required for mycobacterial growth defined by high density mutagenesis.''; Mol Microbiol, 2003 PubMed Europe PMC Scholia
- Lamichhane G, Zignol M, Blades NJ, Geiman DE, Dougherty A, Grosset J, Broman KW, Bishai WR; ''A postgenomic method for predicting essential genes at subsaturation levels of mutagenesis: application to Mycobacterium tuberculosis.''; Proc Natl Acad Sci U S A, 2003 PubMed Europe PMC Scholia
- Griffin JE, Gawronski JD, Dejesus MA, Ioerger TR, Akerley BJ, Sassetti CM; ''High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism.''; PLoS Pathog, 2011 PubMed Europe PMC Scholia
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