Sterol regulatory element-binding proteins (SREBP) signaling (Homo sapiens)

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ERNucleus141230, 441627Lipogenic enzymesGolgi COPII coated vesicle2Positive effectTranscription-TranslationstimulationCholesterol effluxUp regulationLegendNegative effectInhibitionCofactorExact mechanism unknownCatalysisCholesterol synthesisSRE CleavagemiRNA33bGlutaminePKAAMPKSIRT1RBP4LPIN1CAMPAKTOxysterolsimportin betamTORC1HMGCRSREBP2NFYCholesterolgp78CDK8miRNA33aFGF21LXRSCAPUFAsS1PINSIG1GlucoseTRC8PUFAsPI3KATF6InsulinGSK3nSREBP11103404217342031, 3625, 329284, 7, 13181922455SCAP29, 38818396, 21SCAPINSIG2INSIG1INSIG2SREBP1a,-c26, 37SREBP2SREBP1a,-cSREBP2SREBP1a,-cSAR1ASCAPSREBP2SREBP1a,-cSAR1BSAR1ASAR1BSEC23ASEC23BSEC24ASEC24BSEC24CSEC24DSEC13SEC31ASEC31BSEC13SEC23ASEC23BSEC24ASEC24BSEC24CSEC24DSAR1ASCAPSREBF2SREBP1a,-cSAR1BSEC31ASEC31BS2P35SCAPSREBP2SREBP1a,-cnSREBP1a,-cGeneSREnSREBP2GeneCholesterogenic enzymesLipoprotein metabolismCholesterol uptakeCofactorCREBSP115NFYCREBSP1YY141, 43YY1PGC-1betaARC1053323ARC105LSSHMGCSMVDIDIFDPSFDFTSQLECYP51A1LPLLDLRSCARB1ACACAGPAFASNDBIACLYMDHPPARGACSSCDFatty aciddegradationFatty acid synthesisSIRT1INSIG124INSIG2SREBP2SREBP1a,-c


Description

Sterol regulatory element-binding proteins (SREBPs) are membrane-bound proteins that act as transcription factors. They regulate lipid, especially cholesterol, biosynthesis and uptake at a transcriptional level to maintain cellular lipid homeostasis. In addition, SREBP appears to be involved in a variety of other cellular processes. This pathway of SREBP focusses on the regulation of lipid metabolism by SREBP. The data on which this pathway is based, is derived from a variety of in vitro and in vivo studies using different species, including mouse, rat, hamster and human. This pathway served as the basis for a review about SREBP that was published in Genes and Nutrition: PubMed.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
135870view04:21, 20 November 2024EweitzIncrease font size
135869view04:15, 20 November 2024EweitzRefine legend
135868view04:10, 20 November 2024EweitzEconomize layout
127880view02:01, 6 January 2024EweitzModified description
116442view09:47, 7 May 2021EweitzModified title
110111view12:30, 17 April 2020FehrhartConnected lines and converted graphical lines
106704view13:13, 17 September 2019MaintBotHMDB identifier normalization
105824view23:03, 15 August 2019KhanspersModified description
90425view18:38, 13 November 2016EgonwAdded two references about the cholesterol-SCAP interaction.
90350view13:37, 6 November 2016EgonwFixed weird chars in several references.
86074view08:50, 29 June 2016MirellaKalafatiModified title
79943view09:38, 28 April 2015Zariadded anotation for AMPK
78494view10:28, 7 January 2015MaintBotadded missing graphIds
73382view05:26, 25 January 2014MaintBotremoved newlines from datanode labels
71987view11:08, 24 October 2013MkutmonChanged Unknown -> RNA for miRNA33a
71698view19:46, 17 October 2013MaintBotUpdated UniProt/TrEMBL data source
68403view09:40, 5 July 2013EveloModified description
68402view09:39, 5 July 2013EveloModified description
68401view09:32, 5 July 2013EveloAdded reference for review paper.
67653view11:44, 26 June 2013DdiglesOntology Term : 'sterol regulatory element-binding protein signaling pathway' added !
63160view20:19, 8 May 2013MaintBotUpdating gpml version
59430view09:37, 27 February 2013SabinedaemenModified description
59171view18:35, 22 February 2013MaintBotUpdated Ensembl data source
58748view12:15, 20 February 2013Sabinedaemenannotations
58745view09:56, 20 February 2013Sabinedaemenannotations
58744view09:52, 20 February 2013Sabinedaemenannotations
58743view09:01, 20 February 2013Sabinedaemenannotations
58578view10:43, 16 February 2013SabinedaemenModified description
58567view16:25, 15 February 2013Sabinedaemenliterature added
58566view16:21, 15 February 2013Sabinedaemenupdate
58565view10:58, 15 February 2013SabinedaemenRBP4
58564view08:59, 15 February 2013SabinedaemenFGF21
55311view15:16, 13 December 2012SabinedaemenUpdate
55303view15:07, 13 December 2012SabinedaemenPeriodical save, work in progress
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External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACACAGeneProductENSG00000132142 (Ensembl)
ACLY GeneProductENSG00000131473 (Ensembl)
ACS GeneProductENSG00000154930 (Ensembl)
AKTGeneProductENSG00000142208 (Ensembl)
AMPKGeneProductENSG00000249325 (Ensembl)
ARC105GeneProductENSG00000099917 (Ensembl) activator recruited cofactor (ARC)-mediator activator complex
ATF6GeneProductENSG00000118217 (Ensembl)
CAMPGeneProductENSG00000164047 (Ensembl)
CDK8GeneProductENSG00000132964 (Ensembl)
CREBGeneProductENSG00000118260 (Ensembl)
CYP51A1GeneProductENSG00000001630 (Ensembl)
CholesterolMetaboliteHMDB00067 (HMDB)
DBIGeneProductENSG00000155368 (Ensembl)
FASN GeneProductENSG00000169710 (Ensembl)
FDFTGeneProductENSG00000079459 (Ensembl)
FDPSGeneProductENSG00000160752 (Ensembl)
FGF21GeneProductENSG00000105550 (Ensembl)
GPA GeneProductENSG00000119927 (Ensembl)
GSK3GeneProductENSG00000105723 (Ensembl)
GlucoseMetaboliteHMDB00122 (HMDB)
GlutamineMetaboliteHMDB00641 (HMDB)
HMGCRGeneProductENSG00000113161 (Ensembl)
HMGCSGeneProductENSG00000112972 (Ensembl)
IDIGeneProductENSG00000067064 (Ensembl)
INSIG1GeneProductENSG00000186480 (Ensembl)
INSIG2GeneProductENSG00000125629 (Ensembl)
InsulinProteinP01308 (Uniprot-TrEMBL)
LDLRGeneProductENSG00000130164 (Ensembl)
LPIN1GeneProductENSG00000134324 (Ensembl)
LPLGeneProductENSG00000175445 (Ensembl)
LSSGeneProductENSG00000160285 (Ensembl)
LXRGeneProductENSG00000131408 (Ensembl)
MDHGeneProductENSG00000014641 (Ensembl)
MVDGeneProductENSG00000167508 (Ensembl)
NFYGeneProductENSG00000001167 (Ensembl)
OxysterolsMetaboliteCHEBI:53030 (ChEBI)
PGC-1betaGeneProductENSG00000155846 (Ensembl)
PI3KGeneProductENSG00000121879 (Ensembl)
PKAGeneProductENSG00000072062 (Ensembl)
PPARGGeneProductENSG00000132170 (Ensembl)
PUFAsMetaboliteCHEBI:26208 (ChEBI) Inhibition of SREBP1 processing
RBP4GeneProductENSG00000138207 (Ensembl)
S1PGeneProductENSG00000140943 (Ensembl)
S2PGeneProductENSG00000012174 (Ensembl)
SAR1AGeneProductENSG00000079332 (Ensembl)
SAR1BGeneProductENSG00000152700 (Ensembl)
SCAPGeneProductENSG00000114650 (Ensembl)
SCARB1GeneProductENSG00000073060 (Ensembl)
SCDGeneProductENSG00000099194 (Ensembl)
SEC13GeneProductENSG00000157020 (Ensembl)
SEC23AGeneProductENSG00000100934 (Ensembl)
SEC23BGeneProductENSG00000101310 (Ensembl)
SEC24AGeneProductENSG00000113615 (Ensembl)
SEC24BGeneProductENSG00000138802 (Ensembl)
SEC24CGeneProductENSG00000176986 (Ensembl)
SEC24DGeneProductENSG00000150961 (Ensembl)
SEC31AGeneProductENSG00000138674 (Ensembl)
SEC31BGeneProductENSG00000075826 (Ensembl)
SIRT1GeneProductENSG00000096717 (Ensembl)
SP1GeneProductENSG00000185591 (Ensembl)
SQLEGeneProductENSG00000104549 (Ensembl)
SREBF2GeneProductENSG00000198911 (Ensembl)
SREBP1a,-cGeneProductENSG00000072310 (Ensembl)
SREBP2GeneProductENSG00000198911 (Ensembl)
TRC8GeneProductENSG00000170881 (Ensembl)
UFAsMetaboliteCHEBI:26208 (ChEBI)
YY1GeneProductENSG00000100811 (Ensembl)
gp78GeneProductENSG00000159461 (Ensembl)
importin betaGeneProductENSG00000108424 (Ensembl)
mTORC1GeneProductENSG00000198793 (Ensembl)
miRNA33aRnaMI0000091 (miRBase Sequence)
miRNA33bRnaMI0003646 (miRBase Sequence)
nSREBP1a,-cGeneProductENSG00000072310 (Ensembl)
nSREBP2GeneProductENSG00000198911 (Ensembl)
nSREBPGeneProductENSG00000072310 (Ensembl)

Annotated Interactions

No annotated interactions

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