Mitochondrial unfolded-protein response (Caenorhabditis elegans)
From WikiPathways
Description
hypothetical pathway based on a single review article. Input on alternatives is welcome
Quality Tags
Ontology Terms
Bibliography
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- Broadley SA, Hartl FU; ''Mitochondrial stress signaling: a pathway unfolds.''; Trends Cell Biol, 2008 PubMed Europe PMC Scholia
- Haynes CM, Ron D; ''The mitochondrial UPR - protecting organelle protein homeostasis.''; J Cell Sci, 2010 PubMed Europe PMC Scholia
- Pellegrino MW, Nargund AM, Haynes CM; ''Signaling the mitochondrial unfolded protein response.''; Biochim Biophys Acta, 2013 PubMed Europe PMC Scholia
- Haynes CM, Petrova K, Benedetti C, Yang Y, Ron D; ''ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans.''; Dev Cell, 2007 PubMed Europe PMC Scholia
- Yoneda T, Benedetti C, Urano F, Clark SG, Harding HP, Ron D; ''Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones.''; J Cell Sci, 2004 PubMed Europe PMC Scholia
- Baker BM, Nargund AM, Sun T, Haynes CM; ''Protective coupling of mitochondrial function and protein synthesis via the eIF2α kinase GCN-2.''; PLoS Genet, 2012 PubMed Europe PMC Scholia
- Haynes CM, Yang Y, Blais SP, Neubert TA, Ron D; ''The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans.''; Mol Cell, 2010 PubMed Europe PMC Scholia
- Nargund AM, Pellegrino MW, Fiorese CJ, Baker BM, Haynes CM; ''Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation.''; Science, 2012 PubMed Europe PMC Scholia
- Benedetti C, Haynes CM, Yang Y, Harding HP, Ron D; ''Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response.''; Genetics, 2006 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
ATFS-1 Fragments | Metabolite | ||
ATFS-1 | Protein | ZC376.7 (WormBase) | |
CLPP-1 | Protein | ZK970.2 (WormBase) | |
DVE-1 | GeneProduct | ZK1193.5 (WormBase) | |
GCN-2 | Protein | Y81G3A.3 (WormBase) | |
HAF-1 | Protein | C30H6.6 (WormBase) | |
HSP-60 | Protein | Y22D7AL.5 (WormBase) | |
HSP-6 | Protein | C37H5.8 (WormBase) | |
Lon Protease/ C34B2.6 | GeneProduct | C34B2.6 (WormBase) | |
Protein Fragments | Metabolite | ||
UBL-5 | Protein | F46F11.4 (WormBase) | |
Unfolded Proteins | Metabolite | ||
Unknown | |||
hsp-60 | GeneProduct | Y22D7AL.5 (WormBase) | |
hsp-6 | GeneProduct | C37H5.8 (WormBase) | |
translation | Pathway | GO:0006412 (GeneOntology) | |
ubl-5 | GeneProduct | F46F11.4 (WormBase) |
Annotated Interactions
Source | Target | Type | Database reference | Comment |
---|---|---|---|---|
UBL-5 | UBL-5 | Arrow | WBInteraction000502398 (WormBase) | ubl-5 RNAi results in diminished expression of a hsp-60::GFP reporter |
UBL-5 | hsp-6 | mim-stimulation | WBInteraction000520482 (WormBase) | ubl-5 RNAi results in diminished expression of a hsp-6::GFP reporter |