Interleukin-1 (IL-1) structural pathway (Homo sapiens)
From WikiPathways
Description
No description
Quality Tags
Ontology Terms
Bibliography
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- Sims JE, Nicklin MJ, Bazan JF, Barton JL, Busfield SJ, Ford JE, Kastelein RA, Kumar S, Lin H, Mulero JJ, Pan J, Pan Y, Smith DE, Young PR; ''A new nomenclature for IL-1-family genes.''; Trends Immunol, 2001 PubMed Europe PMC Scholia
- Dunn E, Sims JE, Nicklin MJ, O'Neill LA; ''Annotating genes with potential roles in the immune system: six new members of the IL-1 family.''; Trends Immunol, 2001 PubMed Europe PMC Scholia
- Lawson C, Al-Akoum M, Maheux R, Akoum A; ''Increased expression of interleukin-1 receptor type 1 in active endometriotic lesions.''; Reproduction, 2007 PubMed Europe PMC Scholia
- Chang L, Karin M; ''Mammalian MAP kinase signalling cascades.''; Nature, 2001 PubMed Europe PMC Scholia
- Martinon F, Mayor A, Tschopp J; ''The inflammasomes: guardians of the body.''; Annu Rev Immunol, 2009 PubMed Europe PMC Scholia
- Pizarro TT, Cominelli F; ''Cloning IL-1 and the birth of a new era in cytokine biology.''; J Immunol, 2007 PubMed Europe PMC Scholia
- Acuner Ozbabacan SE, Gursoy A, Nussinov R, Keskin O; ''The Structural Pathway of Interleukin 1 (IL-1) Initiated Signaling Reveals Mechanisms of Oncogenic Mutations and SNPs in Inflammation and Cancer.''; PLoS Comput Biol, 2014 PubMed Europe PMC Scholia
- Pathak S, Borodkin VS, Albarbarawi O, Campbell DG, Ibrahim A, van Aalten DM; ''O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release.''; EMBO J, 2012 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
TAK1 | GeneProduct | ENSG00000135341 (Ensembl) | |
ERK1 | GeneProduct | ENSG00000102882 (Ensembl) | |
ERK2 | GeneProduct | ENSG00000100030 (Ensembl) | |
IFN��/�� | Pathway | ||
IKK�� | GeneProduct | ENSG00000104365 (Ensembl) | |
IKK�� | GeneProduct | ENSG00000136560 (Ensembl) | |
IKK�� | GeneProduct | ENSG00000213341 (Ensembl) | |
IL1A | GeneProduct | ENSG00000115008 (Ensembl Human) | |
IL1B | GeneProduct | ENSG00000115008 (Ensembl Human) | |
IL1R1 | GeneProduct | ENSG00000115594 (Ensembl Human) | |
IL1RAP | GeneProduct | ENSG00000196083 (Ensembl Human) | |
IRAK1 | GeneProduct | ENSG00000184216 (Ensembl Human) | |
IRAK2 | GeneProduct | ENSG00000134070 (Ensembl Human) | |
IRAK4 | GeneProduct | ENSG00000198001 (Ensembl Human) | |
IRF7 | GeneProduct | ENSG00000185507 (Ensembl Human) | |
I��B�� | GeneProduct | P25963 (Uniprot-TrEMBL) | |
I��B�� | GeneProduct | Q15653 (Uniprot-SwissProt) | |
JNK1 | GeneProduct | P45983 (Uniprot-TrEMBL) | |
JNK2 | GeneProduct | P45984 (Uniprot-TrEMBL) | |
JNK3 | GeneProduct | P53779 (Uniprot-TrEMBL) | |
MAPKp38�� | GeneProduct | ENSG00000112062 (Ensembl) | |
MAPKp38�� | GeneProduct | ENSG00000185386 (Ensembl) | |
MEKK1 | GeneProduct | ENSG00000095015 (Ensembl) | |
MEKK3 | GeneProduct | ENSG00000198909 (Ensembl) | |
MKK1 | GeneProduct | ENSG00000169032 (Ensembl) | |
MKK2 | GeneProduct | ENSG00000126934 (Ensembl) | |
MKK3 | GeneProduct | MKK3 (Ensembl) | |
MKK4 | GeneProduct | ENSG00000065559 (Ensembl) | |
MKK6 | GeneProduct | ENSG00000108984 (Ensembl) | |
MKK7 | GeneProduct | ENSG00000076984 (Ensembl) | |
MYD88 | GeneProduct | ENSG00000172936 (Ensembl Human) | |
NF-��B p105 | GeneProduct | P19838 (Uniprot-TrEMBL) | |
NIK | GeneProduct | ENSG00000006062 (Ensembl) | |
TAB1 | GeneProduct | ENSG00000100324 (Ensembl) | |
TAB2 | GeneProduct | ENSG00000055208 (Ensembl) | |
TAB3 | GeneProduct | ENSG00000157625 (Ensembl) | |
TOLLIP | GeneProduct | ENSG00000078902 (Ensembl Human) | |
TPL2 | GeneProduct | ||
TRAF6 | GeneProduct | ENSG00000175104 (Ensembl Human) |
Annotated Interactions
No annotated interactions