YAP1- and WWTR1 (TAZ)-stimulated gene expression (Homo sapiens)

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5, 6662-43, 414Ligands of PPARA TBX5WWTR1PCAF cytosolTEADWWTR1RUNX2WWTR1nucleoplasmActivated PPARARXRA Heterodimer TEADYAP1 PPARA Fatty Acid Complex PPARARXRA Coactivator Complex Coactivators of PPARalpha TEAD TEAD WWTR1 RUNX2TEAD1 YAP1 MED1 WWTR1 NCOA1 RUNX2WWTR1TEADYAP1TEAD1 PPARARXRA Coactivator ComplexCREBBPCTGFCARM1TBX5WWTR1PCAFAA WWTR1 TEAD3TEADWWTR1ALA YAP1TEADRUNX2 RXRA TEAD2 NCOA2 LINA TBX5TBL1X TBX5 TEAD3TGS1 PPARA TEAD2 Palm NPPAKAT2BNCOA6 KAT2B EPA SMARCD3 TEAD4 TBL1XR1 CHD9 WWTR1TEAD4 HELZ2 63, 44


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Wikipathways-description 
YAP1 and WWTR1 (TAZ) are transcriptional co-activators, both homologues of the Drosophila Yorkie protein. They both interact with members of the TEAD family of transcription factors, and WWTR1 interacts as well with TBX5 and RUNX2, to promote gene expression. Their transcriptional targets include genes critical to regulation of cell proliferation and apoptosis. Their subcellular location is regulated by the Hippo signaling cascade: phosphorylation mediated by this cascade leads to the cytosolic sequestration of both proteins (Murakami et al. 2005; Oh and Irvine 2010).

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Bibliography

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History

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CompareRevisionActionTimeUserComment
114969view16:49, 25 January 2021ReactomeTeamReactome version 75
113413view11:48, 2 November 2020ReactomeTeamReactome version 74
112615view15:59, 9 October 2020ReactomeTeamReactome version 73
101531view11:40, 1 November 2018ReactomeTeamreactome version 66
101066view21:22, 31 October 2018ReactomeTeamreactome version 65
100596view19:56, 31 October 2018ReactomeTeamreactome version 64
100145view16:41, 31 October 2018ReactomeTeamreactome version 63
99695view15:10, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99283view12:46, 31 October 2018ReactomeTeamreactome version 62
93910view13:44, 16 August 2017ReactomeTeamreactome version 61
93486view11:24, 9 August 2017ReactomeTeamreactome version 61
87190view08:26, 19 July 2016EgonwOntology Term : 'regulatory pathway' added !
86582view09:21, 11 July 2016ReactomeTeamreactome version 56
83145view10:09, 18 November 2015ReactomeTeamVersion54
81495view13:02, 21 August 2015ReactomeTeamVersion53
76971view08:26, 17 July 2014ReactomeTeamFixed remaining interactions
76676view12:04, 16 July 2014ReactomeTeamFixed remaining interactions
76004view10:06, 11 June 2014ReactomeTeamRe-fixing comment source
75710view11:05, 10 June 2014ReactomeTeamReactome 48 Update
75064view13:57, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74708view08:47, 30 April 2014ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AA MetaboliteCHEBI:15843 (ChEBI)
ALA MetaboliteCHEBI:27432 (ChEBI)
CARM1ProteinQ86X55 (Uniprot-TrEMBL)
CHD9 ProteinQ3L8U1 (Uniprot-TrEMBL)
CREBBPProteinQ92793 (Uniprot-TrEMBL)
CTGFProteinP29279 (Uniprot-TrEMBL)
EPA MetaboliteCHEBI:28364 (ChEBI)
HELZ2 ProteinQ9BYK8 (Uniprot-TrEMBL)
KAT2B ProteinQ92831 (Uniprot-TrEMBL)
KAT2BProteinQ92831 (Uniprot-TrEMBL)
LINA MetaboliteCHEBI:17351 (ChEBI)
MED1 ProteinQ15648 (Uniprot-TrEMBL) MED1 is a component of each of the various Mediator complexes, that function as transcription co-activators. The MED1-containing compolexes include the DRIP, ARC, TRIP and CRSP compllexes.
NCOA1 ProteinQ15788 (Uniprot-TrEMBL)
NCOA2 ProteinQ15596 (Uniprot-TrEMBL)
NCOA6 ProteinQ14686 (Uniprot-TrEMBL)
NPPAProteinP01160 (Uniprot-TrEMBL)
PPARA RXRA Coactivator ComplexComplexREACT_20439 (Reactome)
PPARA ProteinQ07869 (Uniprot-TrEMBL)
Palm MetaboliteCHEBI:15756 (ChEBI)
RUNX2 WWTR1ComplexREACT_119164 (Reactome)
RUNX2 ProteinQ13950 (Uniprot-TrEMBL)
RUNX2ProteinQ13950 (Uniprot-TrEMBL)
RXRA ProteinP19793 (Uniprot-TrEMBL)
SMARCD3 ProteinQ6STE5 (Uniprot-TrEMBL)
TBL1X ProteinO60907 (Uniprot-TrEMBL)
TBL1XR1 ProteinQ9BZK7 (Uniprot-TrEMBL)
TBX5

WWTR1

PCAF		ComplexREACT_119245 (Reactome)
TBX5 ProteinQ99593 (Uniprot-TrEMBL)
TBX5ProteinQ99593 (Uniprot-TrEMBL)
TEAD WWTR1ComplexREACT_120065 (Reactome)
TEAD YAP1ComplexREACT_119773 (Reactome)
TEAD1 ProteinP28347 (Uniprot-TrEMBL)
TEAD2 ProteinQ15562 (Uniprot-TrEMBL)
TEAD3ProteinQ99594 (Uniprot-TrEMBL)
TEAD4 ProteinQ15561 (Uniprot-TrEMBL)
TEADProteinREACT_119570 (Reactome)
TGS1 ProteinQ96RS0 (Uniprot-TrEMBL)
WWTR1 ProteinQ9GZV5 (Uniprot-TrEMBL)
WWTR1ProteinQ9GZV5 (Uniprot-TrEMBL)
YAP1 ProteinP46937 (Uniprot-TrEMBL)
YAP1ProteinP46937 (Uniprot-TrEMBL)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
KAT2BREACT_118620 (Reactome)
PPARA RXRA Coactivator ComplexArrowREACT_116163 (Reactome)
REACT_116163 (Reactome) The CTGF gene is transcribed to yield mRNA and the mRNA is translated to yield protein. Transcription of the CTGF gene is increased by both YAP1:TEAD and WWTR1(TAZ):TEAD transcriptional coactivator:transcription factor complexes, so that CTFG is one of the many genes whose expression is downregulated by the action of the hippo cascade (Zhang et al. 2009; Zhao et al. 2008).
REACT_118620 (Reactome) In the nucleus the WWTR1 (TAZ) transcriptional coactivator can bind the TBX5 transcription factor and PCAF (KAT2B) histone acetyltransferase to form a complex. The stoichiometry of this complex is unknown (Murakami et al. 2005).
REACT_118717 (Reactome) In the nucleus the WWTR1 (TAZ) transcriptional coactivator can bind the RUNX2 transcription factor to form a complex. This interaction has not been experimentally characterized in human cells but is inferred from properties of the homologous mouse proteins. The stoichiometry of this complex is unknown (Cui et al. 2003).
REACT_118805 (Reactome) In the nucleus the WWTR1 (TAZ) transcriptional coactivator can bind any one of the four TEAD transcription factors to form a complex. The stoichiometry of this complex is unknown (Chan et al. 2009; Zhang et al. 2009).
REACT_118835 (Reactome) In the nucleus the YAP1 transcriptional coactivator can bind any one of the four TEAD transcription factors to form a complex. The stoichiometry of this complex is unknown (Chan et al. 2009).
REACT_118863 (Reactome) Transcription of the NPPA (ANF) gene is stimulated by the action of a transcription factor complex that includes WWTR1 (TAZ), TBX5, and the PCAF (KAT2B) histone acetyltransferase (Murakami et al. 2005).
RUNX2REACT_118717 (Reactome)
TBX5

WWTR1

PCAF		ArrowREACT_118863 (Reactome)
TBX5REACT_118620 (Reactome)
TEAD WWTR1ArrowREACT_116163 (Reactome)
TEAD YAP1ArrowREACT_116163 (Reactome)
TEADREACT_118805 (Reactome)
TEADREACT_118835 (Reactome)
WWTR1REACT_118620 (Reactome)
WWTR1REACT_118717 (Reactome)
WWTR1REACT_118805 (Reactome)
YAP1REACT_118835 (Reactome)
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