Nifedipine activity (Homo sapiens)

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81phosphorylationAntiprolerative77phosphorylation81Fe uptakeZn uptakein vivoMETABOLISM liver and small intestineVasodilatationphosphorylationNifedipine86cell growth inhibitionAntithromboticCholesterol8179Lactam derivateNa balance8379, 82, 84867986AntioxidativeNitrosonifedipine81, 88777988Ca uptake8879AntiartherosclerosisAngiogenesis8381Delay G0/G1 --> S-phaseROS77Serum induced DNA synthesisRapid degration by daylight79777979838177Cholesterol esterasePKCKDR/FLK1MAPK1VEGFSODMAP2K1Cholesterol hydrolasePTK2BCa-channelNADPH oxidaseCYP2C11BDKRB2NOCYP3A4PCNA1


Description

Nifedipine (brand names Adalat, Nifediac, Cordipin, Nifedical, and Procardia) is a dihydropyridine calcium channel blocker. Its main uses are as an antianginal (especially in Prinzmetal's angina) and antihypertensive, although a large number of other indications have recently been found for this agent, such as Raynaud's phenomenon, premature labor, and painful spasms of the esophagus in cancer and tetanus patients. It is also commonly used for the small subset of pulmonary hypertension patients whose symptoms respond to calcium channel blockers. Source: Wikipedia (wikipedia:Nifedipine)

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Ontology Terms

 

Bibliography

  1. Hirata A, Igarashi M, Yamaguchi H, Suwabe A, Daimon M, Kato T, Tominaga M; ''Nifedipine suppresses neointimal thickening by its inhibitory effect on vascular smooth muscle cell growth via a MEK-ERK pathway coupling with Pyk2.''; Br J Pharmacol, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
126432view10:11, 28 April 2023EgonwLicense is CCZero
118184view10:51, 25 May 2021EweitzModified title
106191view12:08, 16 August 2019MaintBotHMDB identifier normalization
88585view19:25, 11 August 2016Mkutmonfix unconnected lines
75227view19:24, 12 May 2014Khansperslayout, xrefs, connections
74419view12:42, 18 April 2014EgonwConverted two labels into metabolite DataNodes with an identifier.
71991view11:18, 24 October 2013MkutmonChanged Unknown -> GeneProduct for all annotated data nodes
68905view17:30, 8 July 2013MaintBotUpdated to 2013 gpml schema
67508view11:18, 26 June 2013DdiglesOntology Term : 'nifedipine drug pathway' added !
45358view20:43, 7 October 2011KhanspersModified description
45357view20:42, 7 October 2011KhanspersModified description
45356view20:41, 7 October 2011KhanspersOntology Term : 'heart disease' added !
45355view20:40, 7 October 2011KhanspersOntology Term : 'hypertension' added !
41054view23:17, 1 March 2011MaintBotRemoved redundant pathway information and comments
39776view21:35, 17 January 2011AlexanderPicomore complete title
38868view18:23, 24 September 2010KhanspersChanged line types
34583view22:23, 21 December 2009KhanspersModified categories
34447view18:20, 10 December 2009MaintBotAutomatic update of empty xrefs
26597view19:11, 10 December 2008AlexanderPicoupdate
26595view19:10, 10 December 2008AlexanderPicoadded connectors, database refs and literature ref
26593view19:05, 10 December 2008AlexanderPicoPeriodical save, work in progress
21223view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:test1234]] moved to [[Pathway:WP259]]: Moved to stable identifier
20471view10:39, 7 November 2008RobatwikiNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
BDKRB2GeneProduct624 (Entrez Gene)
CYP2C11
CYP3A4GeneProduct1576 (Entrez Gene)
Ca-channelGeneProduct
Cholesterol esterase
Cholesterol hydrolase
CholesterolMetaboliteCHEBI:16113 (ChEBI)
KDR/FLK1GeneProduct3791 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
NADPH oxidaseGeneProduct
NOMetaboliteHMDB03378 (HMDB)
NifedipineMetaboliteCHEBI:7565 (ChEBI)
PCNAGeneProduct5111 (Entrez Gene)
PKCGeneProduct50818 (Entrez Gene)
PTK2BGeneProduct2185 (Entrez Gene)
SODGeneProduct6647 (Entrez Gene)
VEGFProteinVEGF (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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