Portal:Reactome

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Reactome Pathways

Welcome to the Reactome Portal

The Reactome Portal at WikiPathways maintains pathway content periodically synced with the Reactome collection.

Reactome is an open-source, open access, manually curated and peer-reviewed pathway database. Pathway annotations are authored by expert biologists, in collaboration with Reactome editorial staff. The rationale behind Reactome is to convey the rich information in the visual representations of biological pathways familiar from textbooks and articles in a detailed, computationally accessible format. The core unit of the Reactome data model is the reaction. Entities (nucleic acids, proteins, complexes and small molecules) participating in reactions form causal chain of events or pathways.

Learn more about the Reactome Website and Pathway Analysis tools

Read About Reactome
See our User guide

Reactome website

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Community Curation Initiative

In collaboration with WikiPathways, we have established a custom pathway data exchange pipeline. Reactome pathways are now incorporated into WikiPathways, an open, collaborative platform dedicated to the curation of biological pathways. We encourage you to edit, curate and create pathway content here. The Reactome team will periodically assess and selectively incorporate changes back into our centralized collection.

An open source format converter has been developed that converts Reactome pathways to the GPML format. The converter is available on GitHub.

Getting Started

Use in WikiPathways

Introduction to WikiPathways (slides)
WikiPathways overview.
General help pages

Use in PathVisio

Introduction to PathVisio
How to get started.
You can edit the pathways in PathVisio in the same way as in WikiPathways.
Download the entire collection of human Reactome pathways here and use them for pathway analysis in PathVisio.

Feel free to contact Reactome directly with any questions.

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News and Notes

Jan, 2021 : Currently 510 Reactome pathways (version 75) are part of the WikiPathways Database.
Nov, 2020 : Updated to Reactome version 74, including 2 new SARS-CoV pathways: SARS-CoV-1 Infection and SARS-CoV-2 Infection.
Oct, 2020 : We've bumped up the version of Reactome Pathways to 73; integrated IUPHAR GtP as a new database, included Unit tests on RDF level as part of our Quality Assurance and added pathway ontology tags for each new upload.
Jan, 2020 : The latest NAR Database Issue publication from Reactome The reactome pathway knowledgebase
Nov, 2018 : Version 62, 63, 64, 65 and 66 are now available!
Nov, 2017 : The Reactome team published a new paper: The Reactome Pathway Knowledgebase
Aug, 2017 : Version 61 now available!
May, 2016 : Paper: Reactome from a WikiPathways perspective is out!
Nov, 2015 : Version 54 pathways now available!
Sep, 2015 : Version 53 pathways now available!
WikiPathways Curation Event on Jan 7, 2015 for curating the Reactome Collection!