Eukaryotic translation termination (Homo sapiens)

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1, 532, 43GTP bound eRF3 cytosol80S ribosome 40S ribosomal complex 40S ribosomal complex eRF3-GDPeRF180S RibosomemRNApeptidyl-tRNA Complex 40S ribosomal complex eRF3-GTPeRF180S RibosomemRNApeptidyl-tRNA Complex 80S ribosome 60S ribosomal complex 60S ribosomal complex GDP bound eRF3 80S RibosomemRNApeptidyl-tRNA with elongating peptide 80S ribosome GTP bound eRF3 60S ribosomal complex GDP bound eRF3 eRF3-GDPeRF180S RibosomemRNAtRNA Complex 80S ribosome 60S ribosomal complex 40S ribosomal complex 80S RibosomemRNApeptidyl-tRNA with elongating peptide 80S RibosomemRNApeptidyl-tRNA with elongating peptide RPS3A RPL9 RPL17 RPS15A 5S rRNA RPL24 RPL26 80S RibosomemRNApeptidyl-tRNA with elongating peptideRPL32 RPL26 RPL35A RPS21 RPL26L1RPS29 5S rRNA RPS9 RPL34 RPS24 RPLP2 FAU RPS10 RPS11 RPL39 RPL11 RPSA RPL18 RPL38 RPS14 RPS27 RPS25 RPL23 RPL10 ETF1 RPL10A RPL23 RPS16 RPS20 RPS17 RPS19 RPS11 GSPT2 RPL17 RPL7A RPS24 RPS18 RPL6 RPL34 RPL39 RPL3 RPS16 RPL11 RPL37 RPL31 RPS10 RPS8RPL8 RPL28 RPL41 RPL26 RPL7 RPS14 RPL5 RPL17 RPL3LUBA52RPL23 RPS27 RPL11 RPS4X RPS15 RPSA RPL7 GTP bound eRF3RPS3 RPS24 RPL7 RPS4Y1RPS26 RPS26 ETF1 28S rRNA RPS11 RPL18A RPL35A RPS15A RPS13RPS23 RPL9 RPS5RPL27RPS12 RPS12 GSPT2 RPL6 RPL10 GDP RPS27ARPS17 RPS3A RPLP2 PiRPL23A RPL29 RPL27A RPS2RPL3LRPL13A RPL7A RPL9 RPS18 RPS18 RPL28 RPL17 RPL30RPL6 5S rRNA RPL36 RPLP0 RPL26 RPS16 5.8S rRNA RPL37 RPSA RPL4 RPL37A RPS3A RPL6 RPL12 RPS21 RPL38 GDP RPL13A RPL3 RPL28 RPL13A RPS21 RPL29 RPL32 RPS24 RPLP1RPS12 RPL36A RPLP1RPS23 RPL10A RPLP0 RPL13RPS15A RPL27A RPL18A RPS12 RPLP2 RPL21 RPL24 RPLP1GSPT2 RPL34 UBA52RPS21 RPL22 RPS6 RPS13RPS5RPL13RPS9 RPL5 RPL39 RPL14 RPL10 RPL21 RPL8 RPL19 UBA525.8S rRNA RPL22 RPL19 RPL41 RPS25 RPS15A RPL36 18S rRNA RPL23A RPS6 GSPT2 polypeptideRPS27ARPL34 RPS23 RPS7 5S rRNA RPL27RPS7 RPL37A RPL10A RPS27 FAU RPL3 RPS25 RPL22 RPL38 RPL21 RPL22 RPS20 RPL35A RPL3 RPS3 RPL30RPL35A ETF1RPL4 5.8S rRNA RPL37 RPS14 RPL18 RPL24 RPS11 RPL18A GTP RPS19 RPL29 RPL15RPL26L1RPL36A RPS4X RPL23A RPS19 RPL12 RPL36 RPL36A RPL10A RPS2RPL37A RPL12 RPS5RPS4X RPS818S rRNA RPL12 RPS20 eRF3-GDPeRF180S RibosomemRNApeptidyl-tRNA ComplexRPS28 RPL35 RPL41 RPS4Y1RPL18 RPS15 RPL15RPS19 RPL15RPL13RPS28 RPS3 RPL32 RPL18A RPS6 RPS20 RPL35 RPL30RPL21 RPL13RPL37A RPL15RPLP1RPL36A RPL5 RPL5 RPL14 RPS13RPSA RPL23 RPL10 FAU RPL31 RPS8RPL27RPS9 RPL8 RPL3LRPL3LRPS5RPS25 RPLP0 RPL29 RPS28 RPS3A RPL4 RPL11 RPS8RPS29 RPS28 RPL31 GTP RPL14 RPS2FAU RPL27A RPL30eRF3-GTPeRF180S RibosomemRNApeptidyl-tRNA ComplexRPS16 RPL7A RPL4 RPS29 RPS2RPL27A 5.8S rRNA UBA52RPS4Y1RPS4X RPL23A RPL7 18S rRNA RPS26 RPL13A RPS17 RPL19 RPS7 RPL7A eRF3-GDPeRF180S RibosomemRNAtRNA ComplexRPL28 RPL39 RPS27ARPL19 RPL38 RPS26 RPS27 RPS15 RPL35 28S rRNA RPL37 RPS17 RPS23 RPS14 RPS27ARPL26L1RPS29 RPLP0 28S rRNA RPL41 RPS7 RPL35 RPS13RPS6 RPL18 RPL14 RPL27RPS3 tRNA RPL32 RPS18 RPL31 ETF1 18S rRNA RPS9 RPS10 RPLP2 28S rRNA RPL24 RPL36 RPS4Y1RPL26L1RPS10 RPL8 RPL9 RPS15


Description

No description

Comments

Wikipathways-description 
The arrival of any of the three stop codons (UAA, UAG and UGA) into the ribosomal A-site triggers the binding of a release factor (RF) to the ribosome and subsequent polypeptide chain release. In eukaryotes, the RF is composed of two proteins, eRF1 and eRF3. eRF1 is responsible for the hydrolysis of the peptidyl-tRNA, while eRF3 provides a GTP-dependent function. The ribosome releases the mRNA and dissociates into its two complex subunits, which can reassemble on another molecule to begin a new round of protein synthesis. It should be noted that at present, there is no factor identified in eukaryotes that would be the functional equivalent of the bacterial ribosome release (or recycling) factor, RRF, that catalyzes dissociation of the ribosome from the mRNA following release of the polypeptide

Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=72764

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Bibliography

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  1. Hoshino S, Imai M, Kobayashi T, Uchida N, Katada T.; ''The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein.''; PubMed Europe PMC Scholia
  2. Frolova L, Le Goff X, Rasmussen HH, Cheperegin S, Drugeon G, Kress M, Arman I, Haenni AL, Celis JE, Philippe M.; ''A highly conserved eukaryotic protein family possessing properties of polypeptide chain release factor.''; PubMed Europe PMC Scholia
  3. Salas-Marco J, Bedwell DM.; ''GTP hydrolysis by eRF3 facilitates stop codon decoding during eukaryotic translation termination.''; PubMed Europe PMC Scholia
  4. Jones WM, Scaloni A, Bossa F, Popowicz AM, Schneewind O, Manning JM.; ''Genetic relationship between acylpeptide hydrolase and acylase, two hydrolytic enzymes with similar binding but different catalytic specificities.''; PubMed Europe PMC Scholia
  5. Erlandsson R, Boldog F, Persson B, Zabarovsky ER, Allikmets RL, Sümegi J, Klein G, Jörnvall H.; ''The gene from the short arm of chromosome 3, at D3F15S2, frequently deleted in renal cell carcinoma, encodes acylpeptide hydrolase.''; PubMed Europe PMC Scholia
  6. Figaro S, Scrima N, Buckingham RH, Heurgué-Hamard V.; ''HemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1.''; PubMed Europe PMC Scholia
  7. Hoshino S, Imai M, Mizutani M, Kikuchi Y, Hanaoka F, Ui M, Katada T.; ''Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). Its identification as eRF3 interacting with eRF1.''; PubMed Europe PMC Scholia
  8. Ichikawa S, Kaji A.; ''Molecular cloning and expression of ribosome releasing factor.''; PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
117721view12:33, 22 May 2021EweitzModified title
115033view16:57, 25 January 2021ReactomeTeamReactome version 75
113477view11:55, 2 November 2020ReactomeTeamReactome version 74
112677view16:07, 9 October 2020ReactomeTeamReactome version 73
101594view11:46, 1 November 2018ReactomeTeamreactome version 66
101130view21:31, 31 October 2018ReactomeTeamreactome version 65
100658view20:05, 31 October 2018ReactomeTeamreactome version 64
100208view16:50, 31 October 2018ReactomeTeamreactome version 63
99759view15:16, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
93873view13:42, 16 August 2017ReactomeTeamreactome version 61
93440view11:23, 9 August 2017ReactomeTeamreactome version 61
86531view09:20, 11 July 2016ReactomeTeamreactome version 56
83397view11:07, 18 November 2015ReactomeTeamVersion54
81591view13:08, 21 August 2015ReactomeTeamVersion53
77051view08:35, 17 July 2014ReactomeTeamFixed remaining interactions
76756view12:11, 16 July 2014ReactomeTeamFixed remaining interactions
76081view10:14, 11 June 2014ReactomeTeamRe-fixing comment source
75791view11:32, 10 June 2014ReactomeTeamReactome 48 Update
75141view14:08, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74832view10:05, 30 April 2014ReactomeTeamReactome46
74788view08:52, 30 April 2014ReactomeTeamReactome46
68957view17:38, 8 July 2013MaintBotUpdated to 2013 gpml schema
45251view18:37, 7 October 2011AlexanderPicoOntology Term : 'translation termination pathway' added !
42036view21:52, 4 March 2011MaintBotAutomatic update
39839view05:52, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
18S rRNA ProteinX03205 (EMBL)
28S rRNA ProteinM11167 (EMBL)
5.8S rRNA ProteinJ01866 (EMBL)
5S rRNA ProteinV00589 (EMBL)
80S Ribosome

mRNA

peptidyl-tRNA with elongating peptide		ComplexREACT_4835 (Reactome)
ETF1 ProteinP62495 (Uniprot-TrEMBL)
ETF1ProteinP62495 (Uniprot-TrEMBL)
FAU ProteinP62861 (Uniprot-TrEMBL)
GDP MetaboliteCHEBI:17552 (ChEBI)
GSPT2 ProteinQ8IYD1 (Uniprot-TrEMBL)
GTP MetaboliteCHEBI:15996 (ChEBI)
GTP bound eRF3ComplexREACT_5462 (Reactome)
PiMetaboliteCHEBI:18367 (ChEBI)
RPL10 ProteinP27635 (Uniprot-TrEMBL)
RPL10A ProteinP62906 (Uniprot-TrEMBL)
RPL11 ProteinP62913 (Uniprot-TrEMBL)
RPL12 ProteinP30050 (Uniprot-TrEMBL)
RPL13A ProteinP40429 (Uniprot-TrEMBL)
RPL13ProteinP26373 (Uniprot-TrEMBL)
RPL14 ProteinP50914 (Uniprot-TrEMBL)
RPL15ProteinP61313 (Uniprot-TrEMBL)
RPL17 ProteinP18621 (Uniprot-TrEMBL)
RPL18 ProteinQ07020 (Uniprot-TrEMBL)
RPL18A ProteinQ02543 (Uniprot-TrEMBL)
RPL19 ProteinP84098 (Uniprot-TrEMBL)
RPL21 ProteinP46778 (Uniprot-TrEMBL)
RPL22 ProteinP35268 (Uniprot-TrEMBL)
RPL23 ProteinP62829 (Uniprot-TrEMBL)
RPL23A ProteinP62750 (Uniprot-TrEMBL)
RPL24 ProteinP83731 (Uniprot-TrEMBL)
RPL26 ProteinP61254 (Uniprot-TrEMBL)
RPL26L1ProteinQ9UNX3 (Uniprot-TrEMBL)
RPL27A ProteinP46776 (Uniprot-TrEMBL)
RPL27ProteinP61353 (Uniprot-TrEMBL)
RPL28 ProteinP46779 (Uniprot-TrEMBL)
RPL29 ProteinP47914 (Uniprot-TrEMBL)
RPL3 ProteinP39023 (Uniprot-TrEMBL)
RPL30ProteinP62888 (Uniprot-TrEMBL)
RPL31 ProteinP62899 (Uniprot-TrEMBL)
RPL32 ProteinP62910 (Uniprot-TrEMBL)
RPL34 ProteinP49207 (Uniprot-TrEMBL)
RPL35 ProteinP42766 (Uniprot-TrEMBL)
RPL35A ProteinP18077 (Uniprot-TrEMBL)
RPL36 ProteinQ9Y3U8 (Uniprot-TrEMBL)
RPL36A ProteinP83881 (Uniprot-TrEMBL)
RPL37 ProteinP61927 (Uniprot-TrEMBL)
RPL37A ProteinP61513 (Uniprot-TrEMBL)
RPL38 ProteinP63173 (Uniprot-TrEMBL)
RPL39 ProteinP62891 (Uniprot-TrEMBL)
RPL3LProteinQ92901 (Uniprot-TrEMBL)
RPL4 ProteinP36578 (Uniprot-TrEMBL)
RPL41 ProteinP62945 (Uniprot-TrEMBL)
RPL5 ProteinP46777 (Uniprot-TrEMBL)
RPL6 ProteinQ02878 (Uniprot-TrEMBL)
RPL7 ProteinP18124 (Uniprot-TrEMBL)
RPL7A ProteinP62424 (Uniprot-TrEMBL)
RPL8 ProteinP62917 (Uniprot-TrEMBL)
RPL9 ProteinP32969 (Uniprot-TrEMBL)
RPLP0 ProteinP05388 (Uniprot-TrEMBL)
RPLP1ProteinP05386 (Uniprot-TrEMBL)
RPLP2 ProteinP05387 (Uniprot-TrEMBL)
RPS10 ProteinP46783 (Uniprot-TrEMBL)
RPS11 ProteinP62280 (Uniprot-TrEMBL)
RPS12 ProteinP25398 (Uniprot-TrEMBL)
RPS13ProteinP62277 (Uniprot-TrEMBL)
RPS14 ProteinP62263 (Uniprot-TrEMBL)
RPS15 ProteinP62841 (Uniprot-TrEMBL)
RPS15A ProteinP62244 (Uniprot-TrEMBL)
RPS16 ProteinP62249 (Uniprot-TrEMBL)
RPS17 ProteinP08708 (Uniprot-TrEMBL)
RPS18 ProteinP62269 (Uniprot-TrEMBL)
RPS19 ProteinP39019 (Uniprot-TrEMBL)
RPS20 ProteinP60866 (Uniprot-TrEMBL)
RPS21 ProteinP63220 (Uniprot-TrEMBL)
RPS23 ProteinP62266 (Uniprot-TrEMBL)
RPS24 ProteinP62847 (Uniprot-TrEMBL)
RPS25 ProteinP62851 (Uniprot-TrEMBL)
RPS26 ProteinP62854 (Uniprot-TrEMBL)
RPS27 ProteinP42677 (Uniprot-TrEMBL)
RPS27AProteinP62979 (Uniprot-TrEMBL)
RPS28 ProteinP62857 (Uniprot-TrEMBL)
RPS29 ProteinP62273 (Uniprot-TrEMBL)
RPS2ProteinP15880 (Uniprot-TrEMBL)
RPS3 ProteinP23396 (Uniprot-TrEMBL)
RPS3A ProteinP61247 (Uniprot-TrEMBL)
RPS4X ProteinP62701 (Uniprot-TrEMBL)
RPS4Y1ProteinP22090 (Uniprot-TrEMBL)
RPS5ProteinP46782 (Uniprot-TrEMBL)
RPS6 ProteinP62753 (Uniprot-TrEMBL)
RPS7 ProteinP62081 (Uniprot-TrEMBL)
RPS8ProteinP62241 (Uniprot-TrEMBL)
RPS9 ProteinP46781 (Uniprot-TrEMBL)
RPSA ProteinP08865 (Uniprot-TrEMBL)
UBA52ProteinP62987 (Uniprot-TrEMBL)
eRF3-GDP

eRF1 80S Ribosome mRNA

peptidyl-tRNA Complex		ComplexREACT_5057 (Reactome)
eRF3-GDP

eRF1 80S Ribosome mRNA

tRNA Complex		ComplexREACT_4303 (Reactome)
eRF3-GTP

eRF1 80S Ribosome mRNA

peptidyl-tRNA Complex		ComplexREACT_4059 (Reactome)
polypeptideREACT_3573 (Reactome)
tRNA MetaboliteCHEBI:17843 (ChEBI)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
80S Ribosome

mRNA

peptidyl-tRNA with elongating peptide		REACT_227 (Reactome)
ETF1REACT_227 (Reactome)
GTP bound eRF3REACT_227 (Reactome)
PiArrowREACT_1654 (Reactome)
REACT_1654 (Reactome) Please note that this reaction was inferred from experiments performed using Saccharomyces cerevisiae.
REACT_227 (Reactome) Please note that this reaction was inferred from experiments performed using Saccharomyces cerevisiae.
REACT_389 (Reactome) Please note that this reaction was inferred from experiments performed using Saccharomyces cerevisiae.
eRF3-GDP

eRF1 80S Ribosome mRNA

peptidyl-tRNA Complex		ArrowREACT_1654 (Reactome)
eRF3-GDP

eRF1 80S Ribosome mRNA

tRNA Complex		ArrowREACT_389 (Reactome)
polypeptideArrowREACT_389 (Reactome)
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1813"
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