Immunoregulatory interactions between lymphoid and non-lymphoid cells (Homo sapiens)

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8, 12, 14, 3721, 35722, 2692, 18, 284192, 18, 282, 18, 282, 18, 2829, 303, 10, 111, 16, 2713, 15, 312, 18, 28342, 18, 282, 18, 2817, 3632253323, 245, 3229, 30CD40 complexed with CD40L HLA-Bw4 Immunoglobulin Lambda Light Chain HLA-C Cw3 Ig Antibody Light Chain cellHLA-E HLA-A3 interacting with KIR3DL2 C3d complexed with antigen TCR chain alpha Antigen peptide bound class I MHC Complex of CD19, CD81, CD225 and CD21 with C3d-bound Antigen HLA-A3 HLA-C Cw3 ICAM 1-4 HLA-C group-I-interacting KIRs Antigen peptide bound class I MHC Ig Heavy Chain V Region Integrin alphaLbeta2 HLA-A3 CD8 VLA-4 CXADR bound to JAML Antigen-bound Ig G Antibody L-selectin interacting with known ligands Beta-2-microglobulinclass I MHC heavy chain Complex CD3 epsilon delta Integrin alpha4beta7 HLA-C group 2 interacting with KIR2DL1 Antigen-bound Ig G Antibody Immunoglobulin Lambda Light Chain Integrin alpha4beta7 HLA-C group 2 interacting with KIR2DS1 T-cell receptor cellHLA Bw4 interacting with KIR3DL1 HLA-G HLA-G interacting with KIR2DL4 NKG2D ligand T-cell receptor complex with CD8 TCR chain beta MHC Class I CD3 epsilon gamma KIR2DS2 complexed with DAP12 Ig Heavy Chain V Region Integrin alpha4beta7MADCAM1 Antigen-bound antibody bound to lymphoid Fc gamma receptors HLA-C Cw3 CD3 epsilon gamma C3d complexed with antigen HLA-E Ig Lamda Light Chain V Region cellVLA-4VCAM-1 HLA-C Cw4 MHC Class I T-cell receptor complex CD200 bound to CD200R Complex of CD19, CD81, CD225 and CD21 Ig Antibody Light Chain CD96PVR Ig Kappa Light Chain V Region T-cell receptor complex HLA-C group 1 interacting with KIR2DS2 Ligand interacting with NKG2D KIR2DS1 complexed with DAP12 HLA-C Cw4 CD226 bound to Nectin 2 Ig Lamda Light Chain V Region CD226PVR LILR-interacting MHC Class I molecules TCR chain alpha Beta-2-microglobulinclass I MHC heavy chain Complex VLA-4 CD8 HLA-E interacting with KLRC1KLRD1 Ig Lambda C region T-cell receptor complex with CD8 TCR chain beta HLA-C group 1 interacting with KIR2DL2/3 T-cell receptor LILR-interacting MHC Class I molecules Immunoglobulin Kappa Light Chain LFA-1ICAM 1-4 TCR interacting with antigen-bearing MHC Class I Ig Kappa Light Chain V Region Complex of CD19, CD81, CD225 and CD21 Integrin alphaLbeta2 NKG2D complexed with DAP10 Ig Lambda C region E-cadherin bound to KLRG1 CRTAM bound to NECL2 cellL-selectin ligands CD3 epsilon delta HLA-G NKG2D complexed with DAP10 Lymphoid-expressed Fc-gamma receptors MHC Class I interacting with CD160 KIR2DS2 complexed with DAP12 MHC Class I interacting with LILRs HLA-Bw4 KIR2DS1 complexed with DAP12 Immunoglobulin Kappa Light Chain HLA-C Cw4 Ig lambda chain V-II region BO AMICA1HLA-EIGLV3-22IGLV4-69IGLC7CD200 bound to CD200RHLA class I histocompatibility antigen, A-11 alpha chain CRTAM bound to NECL2Ig kappa chain V-III region WOL Ig lambda chain V-I region NEWM HLA class I histocompatibility antigen, Cw-7 alpha chain precursor HLA-C group-I-interacting KIRsIGLV11-55ICAM4 Ig lambda chain V-II region TOG CRTAMIg heavy chain V-II region ARH-77 HLA class I histocompatibility antigen, A-1 alpha chain precursor HLA class I histocompatibility antigen, Cw-18 alpha chain Ig lambda chain V-I region NIG-64 IGLV2-11Ig lambda chain V-IV region Kern NKG2D ligandHLA class I histocompatibility antigen, A-69 alpha chain ICAM 1-4HLA class I histocompatibility antigen, alpha chain G precursor Ig kappa chain V-II region RPMI 6410 Ig kappa chain V-I region Rei TRACIg kappa chain V-I region Daudi Ig lambda chain V-IV region Kern Ig lambda chain V-IV region Hil KIR2DL2 CD3D Ig lambda chain V-VI region WLT IGLV3-27IGHV7-81HLA-C group 1 interacting with KIR2DL2/3IGLV3-16C3d fragment Ig kappa chain V-I region AU Antigen peptide bound class I MHCIg kappa chain V-III region CLL HLA class I histocompatibility antigen, Cw-5 alpha chain precursor HLA class I histocompatibility antigen, E alpha chain precursor IgH heavy chain V-III region VH26 precursor Ig lambda chain V-III region SH CD247-1 Ig kappa chain V-I region Walker CD3D Ig lambda chain V-I region BL2 Ig heavy chain V-II region MCE IGKCCD3G IGKV4-1Ig kappa chain V-II region FR Ig kappa chain V-I region Gal CD226 bound to Nectin 2Ig kappa chain V-I region BAN Ig lambda chain V-I region HA class I MHC B27 CD81 CD19 ITGAL class I MHC B41 Ig heavy chain V-I region HG3 Ig kappa chain V-III region NG9 Ig kappa chain V-III region B6 ULBP3 ITGA4KLRD1ICAM2Ig lambda chain V-VI region WLT class I MHC B35 Ig heavy chain V-III region TUR IGLV2-11Ig kappa chain V-I region Lay Ig lambda chain V-II region BUR HLA class I histocompatibility antigen, A-32 alpha chain class I MHC B82 Ig kappa chain V-III region HAH Ig lambda chain V-I region NIG-64 CD3G IGLV2-33class I MHC B38 Ig kappa chain V-I region EU IGHV7-81Ig kappa chain V-III region Ti HLA class I histocompatibility antigen, A-74 alpha chain Ig kappa chain V-III region IARC/BL41 Ig kappa chain V-I region HK101 Ig kappa chain V-I region Hau HLA-E interacting with KLRC1KLRD1class I MHC B7 IGLV1-44class I MHC B46 L-selectin interacting with known ligandsIg kappa chain V region EV15 HLA class I histocompatibility antigen, A-3 alpha chain precursor TYROBP HLA class I histocompatibility antigen, Cw-16 alpha chain IGLC2Ig heavy chain V-I region Mot CD226PVRclass I MHC B53 Ig kappa chain V-I region Ni class I MHC B81 class I MHC B52 HLA class I histocompatibility antigen, A-3 alpha chain precursor IGLV5-45Ig lambda chain V-VI region SUT class I MHC B59 Ig kappa chain V-III region POM TCRA Ig kappa chain V-II region MIL Ig kappa chain V-I region Daudi class I MHC B50 Ig lambda chain V-IV region Bau HLA class I histocompatibility antigen, A-24 alpha chain HLA class I histocompatibility antigen, alpha chain G precursor B2MHLA class I histocompatibility antigen, Cw-1 alpha chain class I MHC B39 Ig kappa chain V-I region Walker Ig heavy chain V-III region POM Ig heavy chain V-I region ND VCAM1 Ig heavy chain V-II region DAW HLA class I histocompatibility antigen, A-3 alpha chain precursor Ig heavy chain V-II region SESS Ig kappa chain V-IV region JI Ig kappa chain V-II region TEW IGLV3-27HLA-C group 2 interacting with KIR2DS1B2MHLA class I histocompatibility antigen, A-1 alpha chain precursor KLRK1 ITGA4HLA-C group 2 interacting with KIR2DL1B2MIGKCAntigen-bound Ig G AntibodyHLA class I histocompatibility antigen, A-24 alpha chain FCGR2B Ig lambda chain V-I region MEM HLA class I histocompatibility antigen, A-80 alpha chain IGKV1-5IGLV1-36LFA-1ICAM 1-4PVRIg heavy chain V-II region OU class I MHC B42 Ig heavy chain V-III region WEA Ig kappa chain V-I region OU HLA-GKIR3DL1 class I MHC B54 ITGB2 HLA class I histocompatibility antigen, Cw-12 alpha chain Ig heavy chain V-II region HE class I MHC B56 Ig kappa chain V-IV region B17 class I MHC B78 Ig kappa chain V-I region EU Ig heavy chain V-III region TIL HLA class I histocompatibility antigen, A-3 alpha chain precursor Ig kappa chain V-III region CLL IGLV7-43Complex of CD19, CD81, CD225 and CD21 with C3d-bound AntigenITGB7 CD96PVRIg kappa chain V-III region SIE Ig heavy chain V-III region GAL class I MHC B18 HLA class I histocompatibility antigen, Cw-14 alpha chain CXADRIg lambda chain V-II region BOH TRBC1Ig lambda chain V-I region HA KIR2DS1 Ig lambda chain V-I region NEW L-selectin ligandsITGB2 Ig kappa chain V-I region AG HLA class I histocompatibility antigen, A-43 alpha chain Ig kappa chain V-IV region Len CD200R1 HLA class I histocompatibility antigen, Cw-17 alpha chain MADCAM1-1 Ig lambda chain V-I region NEWM AMICA1 TRBC1Ig lambda chain V-II region TOG ITGB7 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor IGLC6Ig lambda chain V-II region WIN Ig heavy chain V-II region COR T-cell receptor alpha chain V region HPB-MLT precursor HLA-C Cw3 Ig lambda chain V-II region NIG-84 Ig lambda chain V-I region WAH CD8A class I MHC B18 B2Mclass I MHC B8 Ig heavy chain V-I region Mot IGHVIGLC3Ig lambda chain V-VI region AR Ig kappa chain V-III region POM Ig lambda chain V-II region TRO B2MITGA4HLA class I histocompatibility antigen, A-33 alpha chain class I MHC B27 class I MHC B41 Ig heavy chain V-III region DOB class I MHC B50 class I MHC B58 CD200R1class I MHC B73 class I MHC B67 HLA class I histocompatibility antigen, Cw-18 alpha chain HLA class I histocompatibility antigen, E alpha chain precursor Ig kappa chain V-I region Scw class I MHC B13 IGLV3-16Ig lambda chain V-IV region X HLA class I histocompatibility antigen, Cw-5 alpha chain precursor Ig heavy chain V-II region SESS IGLV2-33Ig kappa chain V-I region Lay KLRD1 IGLV8-61Ig lambda chain V-II region VIL Ig heavy chain V-III region TRO Ig kappa chain V-II region TEW NKG2D complexed with DAP10Ig kappa chain V-I region WAT KIR2DL4Ig heavy chain V-III region BUT Ig kappa chain V-II region Cum Complex of CD19, CD81, CD225 and CD21Ig kappa chain V-III region VG Ig kappa chain V-II region Cum IGLV3-22Ig lambda chain V-IV region MOL TCRB Ig heavy chain V-II region DAW Ig lambda chain V-I region EPS FCGR3A KIR3DL2HLA class I histocompatibility antigen, alpha chain G precursor Ig heavy chain V-III region POM Ig heavy chain V-II region NEWM HLA class I histocompatibility antigen, A-31 alpha chain CD160PVR Ig kappa chain V-II region GM607 IGLV1-36IGLC1IGKVA18Ig kappa chain V-IV region STH class I MHC B40 HLA class I histocompatibility antigen, A-34 alpha chain Ig lambda chain V-II region NIG-84 HLA class I histocompatibility antigen, Cw-16 alpha chain HLA class I histocompatibility antigen, Cw-6 alpha chain precursor HLA-A3HLA Bw4 interacting with KIR3DL1Ig heavy chain V-III region TEI class I MHC B38 Ig kappa chain V-II region FR HLA class I histocompatibility antigen, A-23 alpha chain IGLV2-23Ig heavy chain V-III region CAM IGLV5-37Ig kappa chain V-II region MIL HLA class I histocompatibility antigen, Cw-2 alpha chain CD8B CD40LGIg heavy chain V-III region BUT Ig lambda chain V-II region NIG-58 Ig lambda chain V-II region TRO ICAM1 HLA-G interacting with KIR2DL4HLA class I histocompatibility antigen, Cw-2 alpha chain HLA class I histocompatibility antigen, Cw-14 alpha chain class I MHC B67 Ig heavy chain V-II region COR Ig lambda chain V-VI region NIG-48 CD8A IGLV1-40B2MIGLV2-18class I MHC B13 CRTAMIg kappa chain V-III region VG IGLV5-37HLA class I histocompatibility antigen, A-26 alpha chain HLA class I histocompatibility antigen, A-80 alpha chain IGLV3-12B2MVLA-4CD40 complexed with CD40Lclass I MHC B37 class I MHC B14 Ig heavy chain V-III region KOL Ig kappa chain V-I region DEE ITGB1 CD200Ig lambda chain V-VI region NIG-48 CD226 T-cell receptor complex with CD8ITGAL Ig lambda chain V-VI region SUT KIR2DS2 TYROBP IGLV1-40HLA class I histocompatibility antigen, A-43 alpha chain B2MIg lambda chain V-II region VIL Ig lambda chain V-VI region EB4 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor IGLV4-3HLA class I histocompatibility antigen, Cw-12 alpha chain Ig lambda chain V-I region VOR HLA class I histocompatibility antigen, A-68 alpha chain Ig kappa chain V-II region RPMI 6410 Ig lambda chain V-IV region MOL Ig heavy chain V-III region GAL Ig heavy chain V-I region HG3 IGLV7-46LILR-interacting MHC Class I moleculesIGHVHLA class I histocompatibility antigen, A-2 alpha chain TRBV12-3 HLA class I histocompatibility antigen, A-34 alpha chain HLA class I histocompatibility antigen, Cw-6 alpha chain precursor CD19 class I MHC B14 HLA class I histocompatibility antigen, A-26 alpha chain Ig heavy chain V-III region WEA HLA class I histocompatibility antigen, A-33 alpha chain Ig lambda chain V-III region LOI HLA class I histocompatibility antigen, A-30 alpha chain Ig heavy chain V-III region NIE TRBV12-3 class I MHC B8 KLRK1 PVR HLA class I histocompatibility antigen, alpha chain F precursor Ig kappa chain V-III region VH class I MHC B55 Ig kappa chain V-I region OU HLA class I histocompatibility antigen, A-32 alpha chain Ig heavy chain V-III region WAS HLA class I histocompatibility antigen, Cw-3 alpha chain precursor HLA class I histocompatibility antigen, Cw-4 alpha chain precursor class I MHC B35 Ig kappa chain V-III region NG9 class I MHC B47 KIR3DL1KIR2DL4 HLA class I histocompatibility antigen, A-29 alpha chain Ig kappa chain V-I region Mev HLA class I histocompatibility antigen, A-2 alpha chain Ig kappa chain V-I region Ka class I MHC B55 TYROBP HLA class I histocompatibility antigen, A-25 alpha chain Ig kappa chain V-I region BAN Ig heavy chain V-III region ZAP PVRL2 CDH1KIR2DL1MHC Class I interacting with CD160Ig lambda chain V-III region LOI class I MHC B73 class I MHC B46 IGLV5-45Ig heavy chain V-III region TRO Ig lambda chain V-II region BO Ig kappa chain V-I region Ni IGLC7Ig lambda chain V-II region NEI HLA class I histocompatibility antigen, Cw-4 alpha chain precursor class I MHC B45 B2MIg kappa chain V-II region GM607 class I MHC B82 Ig kappa chain V-I region AU Ig heavy chain V-III region JON class I MHC B59 MICAclass I MHC B45 Ig kappa chain V-I region Scw IGLV4-60Ig heavy chain V-III region ZAP IGLV4-60Ig kappa chain V-I region WEA class I MHC B38 IGLV2-18HLA class I histocompatibility antigen, A-66 alpha chain Ig kappa chain V-I region Wes Ig kappa chain V region EV15 class I MHC B53 T-cell receptor alpha chain V region PY14 precursor Ig heavy chain V-II region HE Ig kappa chain V-I region Wes IGLV3-12Ig kappa chain V-I region Bi Antigen-bound antibody bound to lymphoid Fc gamma receptorsHLA class I histocompatibility antigen, E alpha chain precursor class I MHC B44 KLRG1 class I MHC B49 IGLC3KLRG1Ig heavy chain V-III region HIL Ig heavy chain V-III region BRO Integrin alpha4beta7class I MHC B42 Ig kappa chain V-I region Mev TYROBP KIR2DS1 Ig heavy chain V-III region BRO class I MHC B39 Ig lambda chain V-V region DEL KIR2DS2 Ig heavy chain V-III region TEI T-cell receptor alpha chain V region PY14 precursor Ig lambda chain V-II region MGC HCSTHLA class I histocompatibility antigen, Cw-3 alpha chain precursor KIR2DL3 CD160 B2MIg heavy chain V-II region WAH class I MHC B44 Ig lambda chain V region 4A TRACHLA-C group 1 interacting with KIR2DS2HLA class I histocompatibility antigen, Cw-17 alpha chain Ig heavy chain V-I region ND CD96Ig heavy chain V-III region HIL MHC Class I interacting with LILRsVLA-4VCAM-1IGLVCD96B2Mclass I MHC B57 HLA class I histocompatibility antigen, alpha chain F precursor class I MHC B56 Ig kappa chain V-IV region Len MADCAM1-1 HLA class I histocompatibility antigen, A-31 alpha chain IFITM1 CXADR bound to JAMLHLA class I histocompatibility antigen, A-23 alpha chain Ig lambda chain V-VII region MOT Ig heavy chain V-I region EU Ig lambda chain V-IV region Hil Ig kappa chain V-III region GOL B2MIg heavy chain V-III region BUR RAET1E Ig lambda chain V-II region BOH class I MHC B40 Ig heavy chain V-III region TUR Ig kappa chain V-I region Hau class I MHC B52 class I MHC B49 B2MIg heavy chain V-III region DOB HLA class I histocompatibility antigen, A-25 alpha chain Ig lambda chain V-II region MGC Ig heavy chain V-III region GA Ig heavy chain V-I region SIE B2MCD3E IGLVHLA class I histocompatibility antigen, Cw-3 alpha chain precursor HLA-C Cw4 Ig heavy chain V-II region ARH-77 IGLV10-54Ig kappa chain V-I region Rei Integrin alpha4beta7MADCAM1Ig kappa chain V-I region DEE Ig kappa chain V-I region Bi HLA class I histocompatibility antigen, Cw-3 alpha chain precursor class I MHC B54 Ig lambda chain V-I region WAH IGLC6HLA class I histocompatibility antigen, A-66 alpha chain IGLV1-44IGLV7-46CD226 CD40-1CD34-1 CD8B Ig heavy chain V-I region EU IGKV4-1Ig heavy chain V-II region OU CD40LGHLA class I histocompatibility antigen, E alpha chain precursor class I MHC B57 Ligand interacting with NKG2DIg lambda chain V-I region BL2 Ig heavy chain V-III region NIE HLA class I histocompatibility antigen, Cw-15 alpha chain class I MHC B15 Ig lambda chain V-IV region X Integrin alphaLbeta2 GLYCAM1 Ig heavy chain V-II region MCE HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, A-68 alpha chain SELL HLA-A3 interacting with KIR3DL2PVRL2 MICBIGKV1-5HLA class I histocompatibility antigen, Cw-4 alpha chain precursor KLRC1 Ig lambda chain V-VI region AR Ig kappa chain V-I region Roy HCSTIg kappa chain V-I region AG IGLV10-54MADCAM1-1Ig lambda chain V-II region BUR MHC Class I molecules interacting with CD160IGLV4-69IGLV2-23Ig heavy chain V-III region JON HLA class I histocompatibility antigen, A-74 alpha chain Ig heavy chain V-III region CAM Ig heavy chain V-I region WOL class I MHC B78 VCAM1Ig kappa chain V-III region IARC/BL41 Ig kappa chain V-III region Ti CD3E Ig lambda chain V-II region NEI CD200 Ig lambda chain V-III region SH Ig kappa chain V-IV region JI IGLV11-55B2MHLA class I histocompatibility antigen, Cw-4 alpha chain precursor Ig lambda chain V-VII region MOT IGLV4-3Ig kappa chain V-III region SIE Ig kappa chain V-III region VH IGLC2class I MHC B81 Ig heavy chain V-III region TIL Ig kappa chain V-III region B6 class I MHC B15 ITGB1 Ig kappa chain V-I region WAT HLA class I histocompatibility antigen, A-36 alpha chain ITGA4Ig heavy chain V-II region WAH Ig heavy chain V-III region LAY Ig kappa chain V-I region WEA TCRA Ig kappa chain V-I region Kue HLA class I histocompatibility antigen, A-69 alpha chain T-cell receptor alpha chain V region HPB-MLT precursor Ig kappa chain V-I region Roy CD226class I MHC B47 HLA class I histocompatibility antigen, Cw-8 alpha chain Ig kappa chain V-III region WOL IFITM1 KIR3DL2 HLA class I histocompatibility antigen, Cw-1 alpha chain IGLV3-25CD247-1 HLA class I histocompatibility antigen, Cw-8 alpha chain HLA class I histocompatibility antigen, Cw-15 alpha chain Ig heavy chain V-III region WAS HLA-Bw4Ig kappa chain V-I region HK101 SELLIg kappa chain V-IV region B17 Ig heavy chain V-III region KOL Ig kappa chain V-IV region STH B2MIg heavy chain V-I region SIE TCR interacting with antigen-bearing MHC Class IHLA class I histocompatibility antigen, Cw-3 alpha chain precursor Ig heavy chain V-II region NEWM HLA class I histocompatibility antigen, A-11 alpha chain IGLV8-61LILR setULBP1 class I MHC B51 CDH1class I MHC B37 Ig lambda chain V-I region MEM IGLC1cd21Ig lambda chain V-VI region EB4 class I MHC B38 CD40-1 Ig kappa chain V-III region HIC Lymphoid-expressed Fc-gamma receptorsIg lambda chain V-II region WIN IGLV3-25Ig heavy chain V-III region BUR Ig kappa chain V-III region GOL HLA class I histocompatibility antigen, alpha chain G precursor B2MKLRC1CD81 Ig lambda chain V-II region NIG-58 Ig kappa chain V-I region Gal HLA class I histocompatibility antigen, A-36 alpha chain KIR2DS1 complexed with DAP12Ig lambda chain V-I region EPS CXADR IGLV7-43PVRL2TCRB Ig lambda chain V-V region DEL KIR2DL1 E-cadherin bound to KLRG1Ig kappa chain V-III region HAH IgH heavy chain V-III region VH26 precursor class I MHC B7 Ig kappa chain V-I region Kue C3d fragment Ig heavy chain V-III region LAY class I MHC B58 Ig heavy chain V-I region WOL IGKVA18Ig lambda chain V region 4A Ig kappa chain V-I region CAR Ig kappa chain V-I region Ka ICAM3 Ig kappa chain V-III region HIC B2MIg lambda chain V-I region VOR class I MHC B51 C3d complexed with antigenKIR2DS2 complexed with DAP12Ig heavy chain V-III region GA HLA class I histocompatibility antigen, A-29 alpha chain cd21Ig lambda chain V-IV region Bau Ig lambda chain V-I region NEW Ig kappa chain V-I region CAR 2, 202, 202, 2062, 20


Description

A number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathogenic organisms.

<p>Molecules such as KIRs and LILRs form part of a crucial surveillance system that looks out for any derangement, usually caused by cancer or viral infection, in MHC Class I presentation. Somatic cells are also able to report internal functional impairment by displaying surface stress markers such as MICA. The presence of these molecules on somatic cells is picked up by C-lectin NK immune receptors.<p><p>Lymphoid cells are able to regulate their location and movement in accordance to their state of activation, and home in on tissues expressing the appropriate complementary ligands. For example, lymphoid cells may fine tune the presence and concentration of adhesion molecules belonging to the IgSF, Selectin and Integrin class that interact with a number of vascular markers of inflammation.<p><p>Furthermore, there are a number of avenues through which lymphoid cells may interact with antigen. This may be presented directly to a specific T-cell receptor in the context of an MHC molecule. Antigen-antibody complexes may anchor to the cell via a small number of lymphoid-specific Fc receptors that may, in turn, influence cell function further. Activated complement factor C3d binds to both antigen and to cell surface receptor CD21. In such cases, the far-reaching influence of CD19 on B-lymphocyte function is tempered by its interaction with CD21. Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=198933</div>

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  33. Cohen-Solal JF, Cassard L, Fridman WH, Sautès-Fridman C.; ''Fc gamma receptors.''; PubMed Europe PMC Scholia
  34. Biassoni R, Falco M, Cambiaggi A, Costa P, Verdiani S, Pende D, Conte R, Di Donato C, Parham P, Moretta L.; ''Amino acid substitutions can influence the natural killer (NK)-mediated recognition of HLA-C molecules. Role of serine-77 and lysine-80 in the target cell protection from lysis mediated by "group 2" or "group 1" NK clones.''; PubMed Europe PMC Scholia
  35. Radaev S, Sun P.; ''Recognition of immunoglobulins by Fcgamma receptors.''; PubMed Europe PMC Scholia
  36. Strong RK.; ''Asymmetric ligand recognition by the activating natural killer cell receptor NKG2D, a symmetric homodimer.''; PubMed Europe PMC Scholia
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  38. Carrasco YR, Batista FD.; ''B cell recognition of membrane-bound antigen: an exquisite way of sensing ligands.''; PubMed Europe PMC Scholia
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  41. Dando J, Wilkinson KW, Ortlepp S, King DJ, Brady RL.; ''A reassessment of the MAdCAM-1 structure and its role in integrin recognition.''; PubMed Europe PMC Scholia
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  44. Gorczynski R, Chen Z, Kai Y, Lee L, Wong S, Marsden PA.; ''CD200 is a ligand for all members of the CD200R family of immunoregulatory molecules.''; PubMed Europe PMC Scholia
  45. Pogge von Strandmann E, Simhadri VR, von Tresckow B, Sasse S, Reiners KS, Hansen HP, Rothe A, Böll B, Simhadri VL, Borchmann P, McKinnon PJ, Hallek M, Engert A.; ''Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells.''; PubMed Europe PMC Scholia
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  47. Falco M, Biassoni R, Bottino C, Vitale M, Sivori S, Augugliaro R, Moretta L, Moretta A.; ''Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells.''; PubMed Europe PMC Scholia
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  49. Kumaresan PR, Lai WC, Chuang SS, Bennett M, Mathew PA.; ''CS1, a novel member of the CD2 family, is homophilic and regulates NK cell function.''; PubMed Europe PMC Scholia
  50. Bromley SK, Burack WR, Johnson KG, Somersalo K, Sims TN, Sumen C, Davis MM, Shaw AS, Allen PM, Dustin ML.; ''The immunological synapse.''; PubMed Europe PMC Scholia
  51. Toapanta FR, Ross TM.; ''Complement-mediated activation of the adaptive immune responses: role of C3d in linking the innate and adaptive immunity.''; PubMed Europe PMC Scholia
  52. Moody DB, Zajonc DM, Wilson IA.; ''Anatomy of CD1-lipid antigen complexes.''; PubMed Europe PMC Scholia
  53. Cemerski S, Shaw A.; ''Immune synapses in T-cell activation.''; PubMed Europe PMC Scholia
  54. Sivori S, Vitale M, Morelli L, Sanseverino L, Augugliaro R, Bottino C, Moretta L, Moretta A.; ''p46, a novel natural killer cell-specific surface molecule that mediates cell activation.''; PubMed Europe PMC Scholia
  55. Yusuf-Makagiansar H, Anderson ME, Yakovleva TV, Murray JS, Siahaan TJ.; ''Inhibition of LFA-1/ICAM-1 and VLA-4/VCAM-1 as a therapeutic approach to inflammation and autoimmune diseases.''; PubMed Europe PMC Scholia
  56. Barral DC, Brenner MB.; ''CD1 antigen presentation: how it works.''; PubMed Europe PMC Scholia
  57. Silk JD, Salio M, Brown J, Jones EY, Cerundolo V.; ''Structural and functional aspects of lipid binding by CD1 molecules.''; PubMed Europe PMC Scholia
  58. Kelley J, Walter L, Trowsdale J.; ''Comparative genomics of natural killer cell receptor gene clusters.''; PubMed Europe PMC Scholia
  59. Vilches C, Parham P.; ''KIR: diverse, rapidly evolving receptors of innate and adaptive immunity.''; PubMed Europe PMC Scholia
  60. Lebbink RJ, de Ruiter T, Adelmeijer J, Brenkman AB, van Helvoort JM, Koch M, Farndale RW, Lisman T, Sonnenberg A, Lenting PJ, Meyaard L.; ''Collagens are functional, high affinity ligands for the inhibitory immune receptor LAIR-1.''; PubMed Europe PMC Scholia
  61. Barrow AD, Palarasah Y, Bugatti M, Holehouse AS, Byers DE, Holtzman MJ, Vermi W, Skjødt K, Crouch E, Colonna M.; ''OSCAR is a receptor for surfactant protein D that activates TNF-α release from human CCR2+ inflammatory monocytes.''; PubMed Europe PMC Scholia
  62. Lebbink RJ, van den Berg MC, de Ruiter T, Raynal N, van Roon JA, Lenting PJ, Jin B, Meyaard L.; ''The soluble leukocyte-associated Ig-like receptor (LAIR)-2 antagonizes the collagen/LAIR-1 inhibitory immune interaction.''; PubMed Europe PMC Scholia
  63. Zen K, Liu Y, McCall IC, Wu T, Lee W, Babbin BA, Nusrat A, Parkos CA.; ''Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial coxsackie and adenovirus receptor and a junctional adhesion molecule-like protein on neutrophils.''; PubMed Europe PMC Scholia
  64. Arnett KL, Harrison SC, Wiley DC.; ''Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment.''; PubMed Europe PMC Scholia
  65. Clark GJ, Green BJ, Hart DN.; ''The CMRF-35H gene structure predicts for an independently expressed member of an ITIM/ITAM pair of molecules localized to human chromosome 17.''; PubMed Europe PMC Scholia
  66. Carter RH, Barrington RA.; ''Signaling by the CD19/CD21 complex on B cells.''; PubMed Europe PMC Scholia
  67. Nishimura T.; ''Expression of potential lymphocyte trafficking mediator molecules in the mammary gland.''; PubMed Europe PMC Scholia
  68. Vitale M, Falco M, Castriconi R, Parolini S, Zambello R, Semenzato G, Biassoni R, Bottino C, Moretta L, Moretta A.; ''Identification of NKp80, a novel triggering molecule expressed by human NK cells.''; PubMed Europe PMC Scholia
  69. Chen K, Huang J, Gong W, Zhang L, Yu P, Wang JM.; ''CD40/CD40L dyad in the inflammatory and immune responses in the central nervous system.''; PubMed Europe PMC Scholia
  70. Sieling PA, Chatterjee D, Porcelli SA, Prigozy TI, Mazzaccaro RJ, Soriano T, Bloom BR, Brenner MB, Kronenberg M, Brennan PJ.; ''CD1-restricted T cell recognition of microbial lipoglycan antigens.''; PubMed Europe PMC Scholia
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  72. Deng L, Mariuzza RA.; ''Structural basis for recognition of MHC and MHC-like ligands by natural killer cell receptors.''; PubMed Europe PMC Scholia
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  74. Tomfohrde J, Silverman A, Barnes R, Fernandez-Vina MA, Young M, Lory D, Morris L, Wuepper KD, Stastny P, Menter A.; ''Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q.''; PubMed Europe PMC Scholia
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  80. Meyaard L, Adema GJ, Chang C, Woollatt E, Sutherland GR, Lanier LL, Phillips JH.; ''LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes.''; PubMed Europe PMC Scholia
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  87. Pende D, Bottino C, Castriconi R, Cantoni C, Marcenaro S, Rivera P, Spaggiari GM, Dondero A, Carnemolla B, Reymond N, Mingari MC, Lopez M, Moretta L, Moretta A.; ''PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis.''; PubMed Europe PMC Scholia
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History

View all...
CompareRevisionActionTimeUserComment
117760view12:54, 22 May 2021EweitzModified title
112459view15:41, 9 October 2020ReactomeTeamReactome version 73
101366view11:25, 1 November 2018ReactomeTeamreactome version 66
100904view21:00, 31 October 2018ReactomeTeamreactome version 65
100445view19:35, 31 October 2018ReactomeTeamreactome version 64
99994view16:18, 31 October 2018ReactomeTeamreactome version 63
99548view14:53, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99181view12:42, 31 October 2018ReactomeTeamreactome version 62
96981view18:21, 24 April 2018AlexanderPicoReverted to version '06:43, 16 August 2017' by AlexanderPico
96973view15:45, 24 April 2018WpblockedModified title
93898view13:43, 16 August 2017ReactomeTeamreactome version 61
93471view11:24, 9 August 2017ReactomeTeamreactome version 61
86567view09:21, 11 July 2016ReactomeTeamreactome version 56
83164view10:14, 18 November 2015ReactomeTeamVersion54
81523view13:03, 21 August 2015ReactomeTeamVersion53
76993view08:28, 17 July 2014ReactomeTeamFixed remaining interactions
76698view12:06, 16 July 2014ReactomeTeamFixed remaining interactions
76024view10:08, 11 June 2014ReactomeTeamRe-fixing comment source
75733view11:21, 10 June 2014ReactomeTeamReactome 48 Update
75083view14:03, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74730view08:48, 30 April 2014ReactomeTeamReactome46
68927view17:33, 8 July 2013MaintBotUpdated to 2013 gpml schema
44851view09:50, 6 October 2011MartijnVanIerselOntology Term : 'signaling pathway pertinent to immunity' added !
42000view21:22, 4 March 2011MaintBotAutomatic update
39855view05:53, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AMICA1 ProteinQ86YT9 (Uniprot-TrEMBL)
AMICA1ProteinQ86YT9 (Uniprot-TrEMBL)
Antigen peptide bound class I MHCComplexREACT_11766 (Reactome)
Antigen-bound Ig G AntibodyComplexREACT_11894 (Reactome) In view of the highly variable nature of antibody proteins, this biological object is an approximate and fragmented representation of an IgM/IgD antibody, given the limitations of Ig chain enumeration in UniProt. A single mRNA transcript is alternatively spliced to give either IgM or IgD. Thus unactivated B cells contain both classes of antibody.
Antigen-bound antibody bound to lymphoid Fc gamma receptorsComplexREACT_11822 (Reactome)
B2MProteinP61769 (Uniprot-TrEMBL)
C3d complexed with antigenComplexREACT_11562 (Reactome)
C3d fragment ProteinP01024 (Uniprot-TrEMBL)
CD160 ProteinO95971 (Uniprot-TrEMBL)
CD160ProteinO95971 (Uniprot-TrEMBL)
CD19 ProteinP15391 (Uniprot-TrEMBL)
CD200 ProteinP41217 (Uniprot-TrEMBL)
CD200 bound to CD200RComplexREACT_11641 (Reactome)
CD200ProteinP41217 (Uniprot-TrEMBL)
CD200R1 ProteinQ8TD46 (Uniprot-TrEMBL)
CD200R1ProteinQ8TD46 (Uniprot-TrEMBL)
CD226 PVRComplexREACT_11602 (Reactome)
CD226 ProteinQ15762 (Uniprot-TrEMBL)
CD226 bound to Nectin 2ComplexREACT_11703 (Reactome)
CD226ProteinQ15762 (Uniprot-TrEMBL)
CD247-1 ProteinP20963-1 (Uniprot-TrEMBL)
CD34-1 ProteinP28906-1 (Uniprot-TrEMBL)
CD3D ProteinP04234 (Uniprot-TrEMBL)
CD3E ProteinP07766 (Uniprot-TrEMBL)
CD3G ProteinP09693 (Uniprot-TrEMBL)
CD40 complexed with CD40LComplexREACT_11386 (Reactome)
CD40-1 ProteinP25942-1 (Uniprot-TrEMBL)
CD40-1ProteinP25942-1 (Uniprot-TrEMBL)
CD40LGProteinP29965 (Uniprot-TrEMBL)
CD81 ProteinP60033 (Uniprot-TrEMBL)
CD8A ProteinP01732 (Uniprot-TrEMBL)
CD8B ProteinP10966 (Uniprot-TrEMBL)
CD96 PVRComplexREACT_11952 (Reactome)
CD96ProteinP40200 (Uniprot-TrEMBL)
CDH1ProteinP12830 (Uniprot-TrEMBL)
CRTAM bound to NECL2ComplexREACT_11356 (Reactome)
CRTAMProteinO95727 (Uniprot-TrEMBL)
CXADR ProteinP78310 (Uniprot-TrEMBL)
CXADR bound to JAMLComplexREACT_11619 (Reactome)
CXADRProteinP78310 (Uniprot-TrEMBL)
Complex of CD19, CD81, CD225 and CD21 with C3d-bound AntigenComplexREACT_11584 (Reactome)
Complex of CD19, CD81, CD225 and CD21ComplexREACT_11777 (Reactome)
E-cadherin bound to KLRG1ComplexREACT_11260 (Reactome)
FCGR2B ProteinP31994 (Uniprot-TrEMBL)
FCGR3A ProteinP08637 (Uniprot-TrEMBL)
GLYCAM1 ProteinQ8IVK1 (Uniprot-TrEMBL)
HCSTProteinQ9UBK5 (Uniprot-TrEMBL)
HLA Bw4 interacting with KIR3DL1ComplexREACT_11950 (Reactome)
HLA class I histocompatibility antigen, A-1 alpha chain precursor ProteinP30443 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-11 alpha chain ProteinP13746 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-2 alpha chain ProteinP01892 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-23 alpha chain ProteinP30447 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-24 alpha chain ProteinP05534 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-25 alpha chain ProteinP18462 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-26 alpha chain ProteinP30450 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-29 alpha chain ProteinP30512 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-3 alpha chain precursor ProteinP04439 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-30 alpha chain ProteinP16188 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-31 alpha chain ProteinP16189 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-32 alpha chain ProteinP10314 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-33 alpha chain ProteinP16190 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-34 alpha chain ProteinP30453 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-36 alpha chain ProteinP30455 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-43 alpha chain ProteinP30456 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-66 alpha chain ProteinP30457 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-68 alpha chain ProteinP01891 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-69 alpha chain ProteinP10316 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-74 alpha chain ProteinP30459 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-80 alpha chain ProteinQ09160 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-1 alpha chain ProteinP30499 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-12 alpha chain ProteinP30508 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-14 alpha chain ProteinP30510 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-15 alpha chain ProteinQ07000 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-16 alpha chain ProteinQ29960 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-17 alpha chain ProteinQ95604 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-18 alpha chain ProteinQ29865 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-2 alpha chain ProteinP30501 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-3 alpha chain precursor ProteinP04222 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-4 alpha chain precursor ProteinP30504 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-5 alpha chain precursor ProteinQ9TNN7 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-6 alpha chain precursor ProteinQ29963 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor ProteinP10321 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-8 alpha chain ProteinP30505 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, E alpha chain precursor ProteinP13747 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, alpha chain F precursor ProteinP30511 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, alpha chain G precursor ProteinP17693 (Uniprot-TrEMBL)
HLA-A3 interacting with KIR3DL2ComplexREACT_11887 (Reactome)
HLA-A3ComplexREACT_11726 (Reactome)
HLA-Bw4ComplexREACT_11642 (Reactome)
HLA-C Cw3 ComplexREACT_11404 (Reactome)
HLA-C Cw4 ComplexREACT_11388 (Reactome)
HLA-C group 1 interacting with KIR2DL2/3ComplexREACT_11577 (Reactome)
HLA-C group 1 interacting with KIR2DS2ComplexREACT_11521 (Reactome)
HLA-C group 2 interacting with KIR2DL1ComplexREACT_11338 (Reactome)
HLA-C group 2 interacting with KIR2DS1ComplexREACT_11864 (Reactome)
HLA-C group-I-interacting KIRsProteinREACT_11748 (Reactome)
HLA-E interacting with KLRC1 KLRD1ComplexREACT_11770 (Reactome)
HLA-EComplexREACT_11603 (Reactome)
HLA-G interacting with KIR2DL4ComplexREACT_11741 (Reactome)
HLA-GComplexREACT_11699 (Reactome)
ICAM 1-4ProteinREACT_11859 (Reactome)
ICAM1 ProteinP05362 (Uniprot-TrEMBL)
ICAM2ProteinP13598 (Uniprot-TrEMBL)
ICAM3 ProteinP32942 (Uniprot-TrEMBL)
ICAM4 ProteinQ14773 (Uniprot-TrEMBL)
IFITM1 ProteinP13164 (Uniprot-TrEMBL)
IGHV7-81ProteinQ6PIL0 (Uniprot-TrEMBL)
IGHVProteinA2KUC3 (Uniprot-TrEMBL)
IGKCProteinP01834 (Uniprot-TrEMBL)
IGKV1-5ProteinP01602 (Uniprot-TrEMBL)
IGKV4-1ProteinP06312 (Uniprot-TrEMBL)
IGKVA18ProteinA2NJV5 (Uniprot-TrEMBL)
IGLC1ProteinP0CG04 (Uniprot-TrEMBL)
IGLC2ProteinP0CG05 (Uniprot-TrEMBL)
IGLC3ProteinP0CG06 (Uniprot-TrEMBL)
IGLC6ProteinP0CF74 (Uniprot-TrEMBL)
IGLC7ProteinA0M8Q6 (Uniprot-TrEMBL)
IGLV1-36ProteinQ5NV67 (Uniprot-TrEMBL)
IGLV1-40ProteinQ5NV69 (Uniprot-TrEMBL)
IGLV1-44ProteinQ5NV81 (Uniprot-TrEMBL)
IGLV10-54ProteinQ5NV86 (Uniprot-TrEMBL)
IGLV11-55ProteinQ5NV87 (Uniprot-TrEMBL)
IGLV2-11ProteinQ5NV84 (Uniprot-TrEMBL)
IGLV2-18ProteinQ5NV65 (Uniprot-TrEMBL)
IGLV2-23ProteinQ5NV89 (Uniprot-TrEMBL)
IGLV2-33ProteinQ5NV66 (Uniprot-TrEMBL)
IGLV3-12ProteinQ5NV85 (Uniprot-TrEMBL)
IGLV3-16ProteinQ5NV64 (Uniprot-TrEMBL)
IGLV3-22ProteinQ5NV75 (Uniprot-TrEMBL)
IGLV3-25ProteinQ5NV90 (Uniprot-TrEMBL)
IGLV3-27ProteinQ5NV91 (Uniprot-TrEMBL)
IGLV4-3ProteinQ5NV61 (Uniprot-TrEMBL)
IGLV4-60ProteinQ5NV79 (Uniprot-TrEMBL)
IGLV4-69ProteinQ5NV92 (Uniprot-TrEMBL)
IGLV5-37ProteinQ5NV68 (Uniprot-TrEMBL)
IGLV5-45ProteinQ5NV82 (Uniprot-TrEMBL)
IGLV7-43ProteinQ5NV80 (Uniprot-TrEMBL)
IGLV7-46ProteinQ5NV83 (Uniprot-TrEMBL)
IGLV8-61ProteinQ5NV62 (Uniprot-TrEMBL)
IGLVProteinA2NXD2 (Uniprot-TrEMBL)
ITGA4ProteinP13612 (Uniprot-TrEMBL)
ITGAL ProteinP20701 (Uniprot-TrEMBL)
ITGB1 ProteinP05556 (Uniprot-TrEMBL)
ITGB2 ProteinP05107 (Uniprot-TrEMBL)
ITGB7 ProteinP26010 (Uniprot-TrEMBL)
Ig heavy chain V-I region EU ProteinP01742 (Uniprot-TrEMBL)
Ig heavy chain V-I region HG3 ProteinP01743 (Uniprot-TrEMBL)
Ig heavy chain V-I region Mot ProteinP06326 (Uniprot-TrEMBL)
Ig heavy chain V-I region ND ProteinP01744 (Uniprot-TrEMBL)
Ig heavy chain V-I region SIE ProteinP01761 (Uniprot-TrEMBL)
Ig heavy chain V-I region WOL ProteinP01760 (Uniprot-TrEMBL)
Ig heavy chain V-II region ARH-77 ProteinP06331 (Uniprot-TrEMBL)
Ig heavy chain V-II region COR ProteinP01815 (Uniprot-TrEMBL)
Ig heavy chain V-II region DAW ProteinP01816 (Uniprot-TrEMBL)
Ig heavy chain V-II region HE ProteinP01818 (Uniprot-TrEMBL)
Ig heavy chain V-II region MCE ProteinP01817 (Uniprot-TrEMBL)
Ig heavy chain V-II region NEWM ProteinP01825 (Uniprot-TrEMBL)
Ig heavy chain V-II region OU ProteinP01814 (Uniprot-TrEMBL)
Ig heavy chain V-II region SESS ProteinP04438 (Uniprot-TrEMBL)
Ig heavy chain V-II region WAH ProteinP01824 (Uniprot-TrEMBL)
Ig heavy chain V-III region BRO ProteinP01766 (Uniprot-TrEMBL)
Ig heavy chain V-III region BUR ProteinP01773 (Uniprot-TrEMBL)
Ig heavy chain V-III region BUT ProteinP01767 (Uniprot-TrEMBL)
Ig heavy chain V-III region CAM ProteinP01768 (Uniprot-TrEMBL)
Ig heavy chain V-III region DOB ProteinP01782 (Uniprot-TrEMBL)
Ig heavy chain V-III region GA ProteinP01769 (Uniprot-TrEMBL)
Ig heavy chain V-III region GAL ProteinP01781 (Uniprot-TrEMBL)
Ig heavy chain V-III region HIL ProteinP01771 (Uniprot-TrEMBL)
Ig heavy chain V-III region JON ProteinP01780 (Uniprot-TrEMBL)
Ig heavy chain V-III region KOL ProteinP01772 (Uniprot-TrEMBL)
Ig heavy chain V-III region LAY ProteinP01775 (Uniprot-TrEMBL)
Ig heavy chain V-III region NIE ProteinP01770 (Uniprot-TrEMBL)
Ig heavy chain V-III region POM ProteinP01774 (Uniprot-TrEMBL)
Ig heavy chain V-III region TEI ProteinP01777 (Uniprot-TrEMBL)
Ig heavy chain V-III region TIL ProteinP01765 (Uniprot-TrEMBL)
Ig heavy chain V-III region TRO ProteinP01762 (Uniprot-TrEMBL)
Ig heavy chain V-III region TUR ProteinP01779 (Uniprot-TrEMBL)
Ig heavy chain V-III region WAS ProteinP01776 (Uniprot-TrEMBL)
Ig heavy chain V-III region WEA ProteinP01763 (Uniprot-TrEMBL)
Ig heavy chain V-III region ZAP ProteinP01778 (Uniprot-TrEMBL)
Ig kappa chain V region EV15 ProteinP06315 (Uniprot-TrEMBL)
Ig kappa chain V-I region AG ProteinP01593 (Uniprot-TrEMBL)
Ig kappa chain V-I region AU ProteinP01594 (Uniprot-TrEMBL)
Ig kappa chain V-I region BAN ProteinP04430 (Uniprot-TrEMBL)
Ig kappa chain V-I region Bi ProteinP01595 (Uniprot-TrEMBL)
Ig kappa chain V-I region CAR ProteinP01596 (Uniprot-TrEMBL)
Ig kappa chain V-I region DEE ProteinP01597 (Uniprot-TrEMBL)
Ig kappa chain V-I region Daudi ProteinP04432 (Uniprot-TrEMBL)
Ig kappa chain V-I region EU ProteinP01598 (Uniprot-TrEMBL)
Ig kappa chain V-I region Gal ProteinP01599 (Uniprot-TrEMBL)
Ig kappa chain V-I region HK101 ProteinP01601 (Uniprot-TrEMBL)
Ig kappa chain V-I region Hau ProteinP01600 (Uniprot-TrEMBL)
Ig kappa chain V-I region Ka ProteinP01603 (Uniprot-TrEMBL)
Ig kappa chain V-I region Kue ProteinP01604 (Uniprot-TrEMBL)
Ig kappa chain V-I region Lay ProteinP01605 (Uniprot-TrEMBL)
Ig kappa chain V-I region Mev ProteinP01612 (Uniprot-TrEMBL)
Ig kappa chain V-I region Ni ProteinP01613 (Uniprot-TrEMBL)
Ig kappa chain V-I region OU ProteinP01606 (Uniprot-TrEMBL)
Ig kappa chain V-I region Rei ProteinP01607 (Uniprot-TrEMBL)
Ig kappa chain V-I region Roy ProteinP01608 (Uniprot-TrEMBL)
Ig kappa chain V-I region Scw ProteinP01609 (Uniprot-TrEMBL)
Ig kappa chain V-I region WAT ProteinP80362 (Uniprot-TrEMBL)
Ig kappa chain V-I region WEA ProteinP01610 (Uniprot-TrEMBL)
Ig kappa chain V-I region Walker ProteinP04431 (Uniprot-TrEMBL)
Ig kappa chain V-I region Wes ProteinP01611 (Uniprot-TrEMBL)
Ig kappa chain V-II region Cum ProteinP01614 (Uniprot-TrEMBL)
Ig kappa chain V-II region FR ProteinP01615 (Uniprot-TrEMBL)
Ig kappa chain V-II region GM607 ProteinP06309 (Uniprot-TrEMBL)
Ig kappa chain V-II region MIL ProteinP01616 (Uniprot-TrEMBL)
Ig kappa chain V-II region RPMI 6410 ProteinP06310 (Uniprot-TrEMBL)
Ig kappa chain V-II region TEW ProteinP01617 (Uniprot-TrEMBL)
Ig kappa chain V-III region B6 ProteinP01619 (Uniprot-TrEMBL)
Ig kappa chain V-III region CLL ProteinP04207 (Uniprot-TrEMBL)
Ig kappa chain V-III region GOL ProteinP04206 (Uniprot-TrEMBL)
Ig kappa chain V-III region HAH ProteinP18135 (Uniprot-TrEMBL)
Ig kappa chain V-III region HIC ProteinP18136 (Uniprot-TrEMBL)
Ig kappa chain V-III region IARC/BL41 ProteinP06311 (Uniprot-TrEMBL)
Ig kappa chain V-III region NG9 ProteinP01621 (Uniprot-TrEMBL)
Ig kappa chain V-III region POM ProteinP01624 (Uniprot-TrEMBL)
Ig kappa chain V-III region SIE ProteinP01620 (Uniprot-TrEMBL)
Ig kappa chain V-III region Ti ProteinP01622 (Uniprot-TrEMBL)
Ig kappa chain V-III region VG ProteinP04433 (Uniprot-TrEMBL)
Ig kappa chain V-III region VH ProteinP04434 (Uniprot-TrEMBL)
Ig kappa chain V-III region WOL ProteinP01623 (Uniprot-TrEMBL)
Ig kappa chain V-IV region B17 ProteinP06314 (Uniprot-TrEMBL)
Ig kappa chain V-IV region JI ProteinP06313 (Uniprot-TrEMBL)
Ig kappa chain V-IV region Len ProteinP01625 (Uniprot-TrEMBL)
Ig kappa chain V-IV region STH ProteinP83593 (Uniprot-TrEMBL)
Ig lambda chain V region 4A ProteinP04211 (Uniprot-TrEMBL)
Ig lambda chain V-I region BL2 ProteinP06316 (Uniprot-TrEMBL)
Ig lambda chain V-I region EPS ProteinP06888 (Uniprot-TrEMBL)
Ig lambda chain V-I region HA ProteinP01700 (Uniprot-TrEMBL)
Ig lambda chain V-I region MEM ProteinP06887 (Uniprot-TrEMBL)
Ig lambda chain V-I region NEW ProteinP01701 (Uniprot-TrEMBL)
Ig lambda chain V-I region NEWM ProteinP01703 (Uniprot-TrEMBL)
Ig lambda chain V-I region NIG-64 ProteinP01702 (Uniprot-TrEMBL)
Ig lambda chain V-I region VOR ProteinP01699 (Uniprot-TrEMBL)
Ig lambda chain V-I region WAH ProteinP04208 (Uniprot-TrEMBL)
Ig lambda chain V-II region BO ProteinP01710 (Uniprot-TrEMBL)
Ig lambda chain V-II region BOH ProteinP01706 (Uniprot-TrEMBL)
Ig lambda chain V-II region BUR ProteinP01708 (Uniprot-TrEMBL)
Ig lambda chain V-II region MGC ProteinP01709 (Uniprot-TrEMBL)
Ig lambda chain V-II region NEI ProteinP01705 (Uniprot-TrEMBL)
Ig lambda chain V-II region NIG-58 ProteinP01713 (Uniprot-TrEMBL)
Ig lambda chain V-II region NIG-84 ProteinP04209 (Uniprot-TrEMBL)
Ig lambda chain V-II region TOG ProteinP01704 (Uniprot-TrEMBL)
Ig lambda chain V-II region TRO ProteinP01707 (Uniprot-TrEMBL)
Ig lambda chain V-II region VIL ProteinP01711 (Uniprot-TrEMBL)
Ig lambda chain V-II region WIN ProteinP01712 (Uniprot-TrEMBL)
Ig lambda chain V-III region LOI ProteinP80748 (Uniprot-TrEMBL)
Ig lambda chain V-III region SH ProteinP01714 (Uniprot-TrEMBL)
Ig lambda chain V-IV region Bau ProteinP01715 (Uniprot-TrEMBL)
Ig lambda chain V-IV region Hil ProteinP01717 (Uniprot-TrEMBL)
Ig lambda chain V-IV region Kern ProteinP01718 (Uniprot-TrEMBL)
Ig lambda chain V-IV region MOL ProteinP06889 (Uniprot-TrEMBL)
Ig lambda chain V-IV region X ProteinP01716 (Uniprot-TrEMBL)
Ig lambda chain V-V region DEL ProteinP01719 (Uniprot-TrEMBL)
Ig lambda chain V-VI region AR ProteinP01721 (Uniprot-TrEMBL)
Ig lambda chain V-VI region EB4 ProteinP06319 (Uniprot-TrEMBL)
Ig lambda chain V-VI region NIG-48 ProteinP01722 (Uniprot-TrEMBL)
Ig lambda chain V-VI region SUT ProteinP06317 (Uniprot-TrEMBL)
Ig lambda chain V-VI region WLT ProteinP06318 (Uniprot-TrEMBL)
Ig lambda chain V-VII region MOT ProteinP01720 (Uniprot-TrEMBL)
IgH heavy chain V-III region VH26 precursor ProteinP01764 (Uniprot-TrEMBL)
Integrin alpha4beta7 MADCAM1ComplexREACT_11447 (Reactome)
Integrin alpha4beta7ComplexREACT_11974 (Reactome)
Integrin alphaLbeta2 ComplexREACT_11837 (Reactome)
KIR2DL1 ProteinP43626 (Uniprot-TrEMBL)
KIR2DL1ProteinP43626 (Uniprot-TrEMBL)
KIR2DL2 ProteinP43627 (Uniprot-TrEMBL)
KIR2DL3 ProteinP43628 (Uniprot-TrEMBL)
KIR2DL4 ProteinQ99706 (Uniprot-TrEMBL)
KIR2DL4ProteinQ99706 (Uniprot-TrEMBL)
KIR2DS1 ProteinQ14954 (Uniprot-TrEMBL)
KIR2DS1 complexed with DAP12ComplexREACT_11752 (Reactome)
KIR2DS2 ProteinP43631 (Uniprot-TrEMBL)
KIR2DS2 complexed with DAP12ComplexREACT_11717 (Reactome)
KIR3DL1 ProteinP43629 (Uniprot-TrEMBL)
KIR3DL1ProteinP43629 (Uniprot-TrEMBL)
KIR3DL2 ProteinP43630 (Uniprot-TrEMBL)
KIR3DL2ProteinP43630 (Uniprot-TrEMBL)
KLRC1 ProteinP26715 (Uniprot-TrEMBL)
KLRC1ProteinP26715 (Uniprot-TrEMBL)
KLRD1 ProteinQ13241 (Uniprot-TrEMBL)
KLRD1ProteinQ13241 (Uniprot-TrEMBL)
KLRG1 ProteinQ96E93 (Uniprot-TrEMBL)
KLRG1ProteinQ96E93 (Uniprot-TrEMBL)
KLRK1 ProteinP26718 (Uniprot-TrEMBL)
L-selectin interacting with known ligandsComplexREACT_11760 (Reactome)
L-selectin ligandsProteinREACT_11759 (Reactome)
LFA-1 ICAM 1-4ComplexREACT_11942 (Reactome)
LILR setProteinREACT_11576 (Reactome)
LILR-interacting MHC Class I moleculesComplexREACT_11528 (Reactome)
Ligand interacting with NKG2DComplexREACT_11751 (Reactome)
Lymphoid-expressed Fc-gamma receptorsProteinREACT_11814 (Reactome)
MADCAM1-1 ProteinQ13477-1 (Uniprot-TrEMBL)
MADCAM1-1ProteinQ13477-1 (Uniprot-TrEMBL)
MHC Class I interacting with CD160ComplexREACT_11275 (Reactome)
MHC Class I interacting with LILRsComplexREACT_11656 (Reactome)
MHC Class I molecules interacting with CD160ComplexREACT_11830 (Reactome)
MICAProteinQ5SS58 (Uniprot-TrEMBL)
MICBProteinQ29980 (Uniprot-TrEMBL)
NKG2D complexed with DAP10ComplexREACT_11468 (Reactome)
NKG2D ligandProteinREACT_11351 (Reactome)
PVR ProteinP15151 (Uniprot-TrEMBL)
PVRL2 ProteinQ92692 (Uniprot-TrEMBL)
PVRL2ProteinQ92692 (Uniprot-TrEMBL)
PVRProteinP15151 (Uniprot-TrEMBL)
RAET1E ProteinQ8TD07 (Uniprot-TrEMBL)
SELL ProteinP14151 (Uniprot-TrEMBL)
SELLProteinP14151 (Uniprot-TrEMBL)
T-cell receptor alpha chain V region HPB-MLT precursor ProteinP04436 (Uniprot-TrEMBL)
T-cell receptor alpha chain V region PY14 precursor ProteinP01737 (Uniprot-TrEMBL)
T-cell receptor complex with CD8ComplexREACT_11534 (Reactome)
TCR interacting with antigen-bearing MHC Class IComplexREACT_11723 (Reactome)
TCRA ProteinP04437 (Uniprot-TrEMBL)
TCRB ProteinP04435 (Uniprot-TrEMBL)
TRACProteinP01848 (Uniprot-TrEMBL)
TRBC1ProteinP01850 (Uniprot-TrEMBL)
TRBV12-3 ProteinP01733 (Uniprot-TrEMBL)
TYROBP ProteinO43914 (Uniprot-TrEMBL)
ULBP1 ProteinQ9BZM6 (Uniprot-TrEMBL)
ULBP3 ProteinQ9BZM4 (Uniprot-TrEMBL)
VCAM1 ProteinP19320 (Uniprot-TrEMBL)
VCAM1ProteinP19320 (Uniprot-TrEMBL)
VLA-4 VCAM-1ComplexREACT_11750 (Reactome)
VLA-4ComplexREACT_11798 (Reactome)
cd21ProteinO15181 (Uniprot-TrEMBL)
class I MHC B13 ProteinP30461 (Uniprot-TrEMBL)
class I MHC B14 ProteinP30462 (Uniprot-TrEMBL)
class I MHC B15 ProteinP30464 (Uniprot-TrEMBL)
class I MHC B18 ProteinP30466 (Uniprot-TrEMBL)
class I MHC B27 ProteinP03989 (Uniprot-TrEMBL)
class I MHC B35 ProteinP30685 (Uniprot-TrEMBL)
class I MHC B37 ProteinP18463 (Uniprot-TrEMBL)
class I MHC B38 ProteinQ95365 (Uniprot-TrEMBL)
class I MHC B39 ProteinP30475 (Uniprot-TrEMBL)
class I MHC B40 ProteinQ04826 (Uniprot-TrEMBL)
class I MHC B41 ProteinP30479 (Uniprot-TrEMBL)
class I MHC B42 ProteinP30480 (Uniprot-TrEMBL)
class I MHC B44 ProteinP30481 (Uniprot-TrEMBL)
class I MHC B45 ProteinP30483 (Uniprot-TrEMBL)
class I MHC B46 ProteinP30484 (Uniprot-TrEMBL)
class I MHC B47 ProteinP30485 (Uniprot-TrEMBL)
class I MHC B49 ProteinP30487 (Uniprot-TrEMBL)
class I MHC B50 ProteinP30488 (Uniprot-TrEMBL)
class I MHC B51 ProteinP18464 (Uniprot-TrEMBL)
class I MHC B52 ProteinP30490 (Uniprot-TrEMBL)
class I MHC B53 ProteinP30491 (Uniprot-TrEMBL)
class I MHC B54 ProteinP30492 (Uniprot-TrEMBL)
class I MHC B55 ProteinP30493 (Uniprot-TrEMBL)
class I MHC B56 ProteinP30495 (Uniprot-TrEMBL)
class I MHC B57 ProteinP18465 (Uniprot-TrEMBL)
class I MHC B58 ProteinP10319 (Uniprot-TrEMBL)
class I MHC B59 ProteinQ29940 (Uniprot-TrEMBL)
class I MHC B67 ProteinQ29836 (Uniprot-TrEMBL)
class I MHC B7 ProteinP01889 (Uniprot-TrEMBL)
class I MHC B73 ProteinQ31612 (Uniprot-TrEMBL)
class I MHC B78 ProteinP30498 (Uniprot-TrEMBL)
class I MHC B8 ProteinP30460 (Uniprot-TrEMBL)
class I MHC B81 ProteinQ31610 (Uniprot-TrEMBL)
class I MHC B82 ProteinQ29718 (Uniprot-TrEMBL)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
AMICA1REACT_11154 (Reactome)
Antigen peptide bound class I MHCREACT_11080 (Reactome)
Antigen-bound Ig G AntibodyREACT_11087 (Reactome)
C3d complexed with antigenREACT_11121 (Reactome)
CD160REACT_11106 (Reactome)
CD200R1REACT_11188 (Reactome)
CD200REACT_11188 (Reactome)
CD226REACT_11094 (Reactome)
CD226REACT_11239 (Reactome)
CD40-1REACT_11241 (Reactome)
CD40LGREACT_11241 (Reactome)
CD96REACT_11207 (Reactome)
CDH1REACT_11212 (Reactome)
CRTAMREACT_11097 (Reactome)
CXADRREACT_11154 (Reactome)
Complex of CD19, CD81, CD225 and CD21REACT_11121 (Reactome)
HLA-A3REACT_11124 (Reactome)
HLA-Bw4REACT_11223 (Reactome)
HLA-C Cw3 REACT_11140 (Reactome)
HLA-C Cw3 REACT_11176 (Reactome)
HLA-C Cw4 REACT_11077 (Reactome)
HLA-C Cw4 REACT_11210 (Reactome)
HLA-C group-I-interacting KIRsREACT_11210 (Reactome)
HLA-EREACT_11119 (Reactome)
HLA-GREACT_11141 (Reactome)
ICAM 1-4REACT_11173 (Reactome)
Integrin alpha4beta7REACT_11199 (Reactome)
Integrin alphaLbeta2 REACT_11173 (Reactome)
KIR2DL1REACT_11140 (Reactome)
KIR2DL4REACT_11141 (Reactome)
KIR2DS1 complexed with DAP12REACT_11077 (Reactome)
KIR2DS2 complexed with DAP12REACT_11176 (Reactome)
KIR3DL1REACT_11223 (Reactome)
KIR3DL2REACT_11124 (Reactome)
KLRC1REACT_11119 (Reactome)
KLRD1REACT_11119 (Reactome)
KLRG1REACT_11212 (Reactome)
L-selectin ligandsREACT_11230 (Reactome)
LILR setREACT_11127 (Reactome)
LILR-interacting MHC Class I moleculesREACT_11127 (Reactome)
Lymphoid-expressed Fc-gamma receptorsREACT_11087 (Reactome)
MADCAM1-1REACT_11199 (Reactome)
MHC Class I molecules interacting with CD160REACT_11106 (Reactome)
NKG2D complexed with DAP10REACT_11178 (Reactome)
NKG2D ligandREACT_11178 (Reactome)
PVRL2REACT_11094 (Reactome)
PVRL2REACT_11097 (Reactome)
PVRREACT_11207 (Reactome)
PVRREACT_11239 (Reactome)
REACT_11077 (Reactome) A hallmark of human NK cells is the expression of HLA class I-specific killer-cell immunoglobulin-like receptors (KIR). KIRs are not only variably expressed on the level of single NK cells but they are also highly polymorphic and polygenic (i.e. the gene content of the KIR cluster varies from individual to individual).

There are 15 functional KIR genes known to date, 11 encoding receptors with two immunoglobulin domains (KIR2D genes) and 4 with three domains (KIR3D genes). Inhibitory KIR genes are characterized by long cytoplasmic tails featuring immunoreceptor tyrosine-based inhibitory motifs (ITIM), which upon engagement transmit inhibitory signals leading to the general shutdown of NK cell effector functions. There are six inhibitory KIRs with clearly defined specificities, all of the inhibitory kind and all for HLA class I allotypes: KIR2DL2 and KIR2DL3 for HLA-C group 1, KIR2DL1 for HLA-C group 2, KIR3DL1 for HLA-B (Bw4 epitope), KIR3DL2 with HLA-A3 and KIR2DL4 with HLA-G.

In contrast, stimulatory KIR have short cytoplasmic tails lacking ITIM, but have a charged amino acid in the transmembrane region that provides a docking site for the activating adapter molecule DAP12. KIR2DS1 is known to bind HLA-C group 2 and KIR2DS2 binds HLA-C group 1.

REACT_11080 (Reactome) T cells distinguish foreign material from self through presentation of fragments of the antigen by the MHC cell surface receptors. Only if an MHC molecule presents an appropriate antigenic peptide will a cellular immune response be triggered. The orchestration of recognition and signaling events, from the initial recognition of antigenic peptides to the lysis of the target cell, is performed in a localized environment on the T cell, called the immunological synapse, and requires the coordinated activities of several T-Cell Receptor (TCR)-associated molecules. This particular reaction depicts the interaction of the TCR with MHC Class I molecules on somatic cell, requiring the support of CD3 and CD8 proteins.
REACT_11087 (Reactome) Most cells of the immune system express receptors for the Fc region of IgG. This heterogeneous family of molecules plays a critical role in immunity, by linking the humoral to the cellular responses. NK cells and B cells have been shown to express exclusively Fc-gamma RIIIa and RIIb respectively.
REACT_11094 (Reactome) NK cells express adhesion molecules that allow interaction with their tumour targets, promoting their lysis.

For instance, the activating receptor CD226 is known to be involved in cytotoxic lymphocyte formation, as well as platelet adhesion to the endothelium. The cytoplasmic domain of CD226 contains binding motifs for members of the band 4.1 family of proteins, and for members of the membrane-associated guanylate kinase homolog (MAGUK) family. These proteins connect the CD226 receptor to the cytoskeleton and may promote clustering with LFA-1 integrin (also discussed in this pathway), which is known to participate in CD226's signaling cascade. CD226 plays a role in transendothelial migration, where it facilitates adherence to endothelial cells and migration between cell junctions.

Nectin-2 binds CD226. It is ubiquitously expressed in cells of various tissues, especially in epithelial cells, neurons and fibroblasts. Like many other nectin and Necl proteins, nectin-2 serves as a viral entry receptor for alpha-herpesviruses including herpes simplex virus (HSV-1 and HSV-2). The other CD226 ligand, Necl-5, was initially identified as a receptor for poliovirus.

CD96, another ligand for Necl-5, is strongly upregulated in activated NK cells.

CRTAM is similarly up-regulated, and has been shown to to bind Necl-2, promoting NK cell cytotoxicity towards otherwise poorly immunogenic targets.

REACT_11097 (Reactome) NK cells express adhesion molecules that allow interaction with their tumour targets, promoting their lysis.

For instance, the activating receptor CD226 is known to be involved in cytotoxic lymphocyte formation, as well as platelet adhesion to the endothelium. The cytoplasmic domain of CD226 contains binding motifs for members of the band 4.1 family of proteins, and for members of the membrane-associated guanylate kinase homolog (MAGUK) family. These proteins connect the CD226 receptor to the cytoskeleton and may promote clustering with LFA-1 integrin (also discussed in this pathway), which is known to participate in CD226's signaling cascade. CD226 plays a role in transendothelial migration, where it facilitates adherence to endothelial cells and migration between cell junctions.

Nectin-2 binds CD226. It is ubiquitously expressed in cells of various tissues, especially in epithelial cells, neurons and fibroblasts. Like many other nectin and Necl proteins, nectin-2 serves as a viral entry receptor for alpha-herpesviruses including herpes simplex virus (HSV-1 and HSV-2). The other CD226 ligand, Necl-5, was initially identified as a receptor for poliovirus.

CD96, another ligand for Necl-5, is strongly upregulated in activated NK cells.

CRTAM is similarly up-regulated, and has been shown to to bind Necl-2, promoting NK cell cytotoxicity towards otherwise poorly immunogenic targets.

REACT_11106 (Reactome) CD160 is a GPI-anchored lymphocyte surface receptor in which expression is mostly restricted to the highly cytotoxic NK cells. MHC class I molecules bind to CD160 receptors on circulating NK lymphocytes and this triggers their cytotoxic activity and cytokine production. NK cells stimulated by IL-15 secrete soluble CD160 protein that binds to MHC-I molecules, resulting in the inhibition of the cytotoxic CD8+ T lymphocyte activity and of the CD160-mediated NK cell cytotoxicity.
REACT_11119 (Reactome) After interaction with its ligand HLA-E, which is expressed on normal cells, the C-type lectin inhibitory receptor CD94/NKG2A suppresses activation signaling processes. CD94/NKG2A receptors continuously recycle from the cell surface through endosomal compartments and back again in a process that requires energy and the cytoskeleton. This steady state process appears to be largely unaffected by exposure to ligand.
REACT_11121 (Reactome) CD19 is a lymphocyte cell surface molecule that functions as a general response regulator or rheostat, which defnes signalling thresholds. These responses are infuenced by signals transduced through a CD19-CD21 cell surface receptor complex, where the binding of complement C3d to CD21 links humoral immune responses with the innate immune system. The CD19-CD21 complex is composed of at least four non-covalently associated proteins: CD19, CD21(complement receptor 2),CD81 and CD225.
REACT_11124 (Reactome) A hallmark of human NK cells is the expression of HLA class I-specific killer-cell immunoglobulin-like receptors (KIR). KIRs are not only variably expressed on the level of single NK cells but they are also highly polymorphic and polygenic (i.e. the gene content of the KIR cluster varies from individual to individual).

There are 15 functional KIR genes known to date, 11 encoding receptors with two immunoglobulin domains (KIR2D genes) and 4 with three domains (KIR3D genes). Inhibitory KIR genes are characterized by long cytoplasmic tails featuring immunoreceptor tyrosine-based inhibitory motifs (ITIM), which upon engagement transmit inhibitory signals leading to the general shutdown of NK cell effector functions. There are six inhibitory KIRs with clearly defined specificities, all of the inhibitory kind and all for HLA class I allotypes: KIR2DL2 and KIR2DL3 for HLA-C group 1, KIR2DL1 for HLA-C group 2, KIR3DL1 for HLA-B (Bw4 epitope), KIR3DL2 with HLA-A3 and KIR2DL4 with HLA-G.

In contrast, stimulatory KIR have short cytoplasmic tails lacking ITIM, but have a charged amino acid in the transmembrane region that provides a docking site for the activating adapter molecule DAP12. KIR2DS1 is known to bind HLA-C group 2 and KIR2DS2 binds HLA-C group 1.

REACT_11127 (Reactome) Leukocyte immunoglobulin (Ig)-like receptors [LILRs, also known as Ig-like transcripts (ILTs)] are a family of inhibitory and stimulatory receptors encoded within the leukocyte receptor complex and are expressed by immune cell types of both myeloid and lymphoid lineage. Several members of the LILR family recognize major histocompatibility complex class I. The immunomodulatory role of LILR receptors indicates that they may exert an influence on signaling pathways of both innate and adaptive immune systems.

Signaling mechanisms are employed that are similar to the ones adopted by the closely related killer cell inhibitory receptors (KIRs). ITIMs recruit inhibitory phosphatases that dephosphorylate ITIM and ITAM domains in order to influence intracellular signaling cascades. In contrast, activating LILRs, which lack any signaling domains of their own, rely on association with an adaptor protein such as FceRI-gamma to transmit their signal through its intracellular ITAMs.

REACT_11140 (Reactome) A hallmark of human NK cells is the expression of HLA class I-specific killer-cell immunoglobulin-like receptors (KIR). KIRs are not only variably expressed on the level of single NK cells but they are also highly polymorphic and polygenic (i.e. the gene content of the KIR cluster varies from individual to individual).

There are 15 functional KIR genes known to date, 11 encoding receptors with two immunoglobulin domains (KIR2D genes) and 4 with three domains (KIR3D genes). Inhibitory KIR genes are characterized by long cytoplasmic tails featuring immunoreceptor tyrosine-based inhibitory motifs (ITIM), which upon engagement transmit inhibitory signals leading to the general shutdown of NK cell effector functions. There are six inhibitory KIRs with clearly defined specificities, all of the inhibitory kind and all for HLA class I allotypes: KIR2DL2 and KIR2DL3 for HLA-C group 1, KIR2DL1 for HLA-C group 2, KIR3DL1 for HLA-B (Bw4 epitope), KIR3DL2 with HLA-A3 and KIR2DL4 with HLA-G.

In contrast, stimulatory KIR have short cytoplasmic tails lacking ITIM, but have a charged amino acid in the transmembrane region that provides a docking site for the activating adapter molecule DAP12. KIR2DS1 is known to bind HLA-C group 2 and KIR2DS2 binds HLA-C group 1.

REACT_11141 (Reactome) A hallmark of human NK cells is the expression of HLA class I-specific killer-cell immunoglobulin-like receptors (KIR). KIRs are not only variably expressed on the level of single NK cells but they are also highly polymorphic and polygenic (i.e. the gene content of the KIR cluster varies from individual to individual).

There are 15 functional KIR genes known to date, 11 encoding receptors with two immunoglobulin domains (KIR2D genes) and 4 with three domains (KIR3D genes). Inhibitory KIR genes are characterized by long cytoplasmic tails featuring immunoreceptor tyrosine-based inhibitory motifs (ITIM), which upon engagement transmit inhibitory signals leading to the general shutdown of NK cell effector functions. There are six inhibitory KIRs with clearly defined specificities, all of the inhibitory kind and all for HLA class I allotypes: KIR2DL2 and KIR2DL3 for HLA-C group 1, KIR2DL1 for HLA-C group 2, KIR3DL1 for HLA-B (Bw4 epitope), KIR3DL2 with HLA-A3 and KIR2DL4 with HLA-G.

In contrast, stimulatory KIR have short cytoplasmic tails lacking ITIM, but have a charged amino acid in the transmembrane region that provides a docking site for the activating adapter molecule DAP12. KIR2DS1 is known to bind HLA-C group 2 and KIR2DS2 binds HLA-C group 1.

REACT_11154 (Reactome) JAM members, such as JAML, bind coxsackie and adenovirus receptor (CXADR) on epithelial and endothelial cells.
REACT_11161 (Reactome) Integrins play a central role in mediating lymphocyte

adhesion to a number of surfaces. LFA-1 interacts with ICAMs 1-3 that are typically expressed on other immune system cells. ICAM-4 also interacts with LFA-1, and is known to be

expressed on telencepahlic neurons.

VCAM-1 regulates lymphocyte adhesion to activated endothelial cells via Very Late Antigen-4 (VLA-4).

To function in a circulating mode, leukocytes express LFA-1 and VLA-4 in a low ligand binding capacity. When leukocytes reach sites of imflammation, these integrins are switched to a higher binding state to guide the complex process of transmigration, tethering, rolling, arrest, adhesion and shape change.

Signal cascades between LFA-1 and VLA-4 may cross-talk affecting binding affinities in a reciprocal fashion.

REACT_11173 (Reactome) Integrins play a central role in mediating lymphocyte

adhesion to a number of surfaces. LFA-1 interacts with ICAMs 1-3 that are typically expressed on other immune system cells. ICAM-4 also interacts with LFA-1, and is known to be

expressed on telencepahlic neurons.

VCAM-1 regulates lymphocyte adhesion to activated endothelial cells via Very Late Antigen-4 (VLA-4).

To function in a circulating mode, leukocytes express LFA-1 and VLA-4 in a low ligand binding capacity. When leukocytes reach sites of imflammation, these integrins are switched to a higher binding state to guide the complex process of transmigration, tethering, rolling, arrest, adhesion and shape change.

Signal cascades between LFA-1 and VLA-4 may cross-talk affecting binding affinities in a reciprocal fashion.

REACT_11176 (Reactome) A hallmark of human NK cells is the expression of HLA class I-specific killer-cell immunoglobulin-like receptors (KIR). KIRs are not only variably expressed on the level of single NK cells but they are also highly polymorphic and polygenic (i.e. the gene content of the KIR cluster varies from individual to individual).

There are 15 functional KIR genes known to date, 11 encoding receptors with two immunoglobulin domains (KIR2D genes) and 4 with three domains (KIR3D genes). Inhibitory KIR genes are characterized by long cytoplasmic tails featuring immunoreceptor tyrosine-based inhibitory motifs (ITIM), which upon engagement transmit inhibitory signals leading to the general shutdown of NK cell effector functions. There are six inhibitory KIRs with clearly defined specificities, all of the inhibitory kind and all for HLA class I allotypes: KIR2DL2 and KIR2DL3 for HLA-C group 1, KIR2DL1 for HLA-C group 2, KIR3DL1 for HLA-B (Bw4 epitope), KIR3DL2 with HLA-A3 and KIR2DL4 with HLA-G.

In contrast, stimulatory KIR have short cytoplasmic tails lacking ITIM, but have a charged amino acid in the transmembrane region that provides a docking site for the activating adapter molecule DAP12. KIR2DS1 is known to bind HLA-C group 2 and KIR2DS2 binds HLA-C group 1.

REACT_11178 (Reactome) NKG2D is an activating immunoreceptor. By engaging NKG2D, HlA Class I-like molecules such as MICA, MICB, ULBP1-4 and RAE-1 provide powerful costimulation for NK cells and T-cells and can determine the magnitude and outcome of certain effector functions. NKG2D ligands are upregulated on the surfaces of cells under conditions of stress, for example infection or tumorigenesis, and therefore act as molecular flags to the immune system that something is wrong.
REACT_11188 (Reactome) While not ubiquitously distributed, CD200 is expressed on a wide range of cell types including thymocytes, B-cells, activated T-cells, follicular dendritic cells,

endothelium, CNS neurons in the central nervous system, cells in reproductive organs, keratinocytes and renal glomeruli.

CD200R is a myeloid-inhibitory receptor, despite the absence of classical ITIMs in the cytoplasmic portion of the protein.

Interestingly, CD200 is also expressed on neurons within the CNS and would be predicted to modulate activation of microglia through CD200R.
REACT_11199 (Reactome) Mucosal addressin cell adhesion molecule (MADCAM1) is present in the endothelium of mucosa, and binds alpha-4 beta-7 integrin and L-selectin, regulating both the passage and retention of leukocytes in mucosal tissues. MADCAM1 has been shown to be present as a homodimer.
REACT_11207 (Reactome) NK cells express adhesion molecules that allow interaction with their tumour targets, promoting their lysis.

For instance, the activating receptor CD226 is known to be involved in cytotoxic lymphocyte formation, as well as platelet adhesion to the endothelium. The cytoplasmic domain of CD226 contains binding motifs for members of the band 4.1 family of proteins, and for members of the membrane-associated guanylate kinase homolog (MAGUK) family. These proteins connect the CD226 receptor to the cytoskeleton and may promote clustering with LFA-1 integrin (also discussed in this pathway), which is known to participate in CD226's signaling cascade. CD226 plays a role in transendothelial migration, where it facilitates adherence to endothelial cells and migration between cell junctions.

Nectin-2 binds CD226. It is ubiquitously expressed in cells of various tissues, especially in epithelial cells, neurons and fibroblasts. Like many other nectin and Necl proteins, nectin-2 serves as a viral entry receptor for alpha-herpesviruses including herpes simplex virus (HSV-1 and HSV-2). The other CD226 ligand, Necl-5, was initially identified as a receptor for poliovirus.

CD96, another ligand for Necl-5, is strongly upregulated in activated NK cells.

CRTAM is similarly up-regulated, and has been shown to to bind Necl-2, promoting NK cell cytotoxicity towards otherwise poorly immunogenic targets.

REACT_11210 (Reactome) A hallmark of human NK cells is the expression of HLA class I-specific killer-cell immunoglobulin-like receptors (KIR). KIRs are not only variably expressed on the level of single NK cells but they are also highly polymorphic and polygenic (i.e. the gene content of the KIR cluster varies from individual to individual).

There are 15 functional KIR genes known to date, 11 encoding receptors with two immunoglobulin domains (KIR2D genes) and 4 with three domains (KIR3D genes). Inhibitory KIR genes are characterized by long cytoplasmic tails featuring immunoreceptor tyrosine-based inhibitory motifs (ITIM), which upon engagement transmit inhibitory signals leading to the general shutdown of NK cell effector functions. There are six inhibitory KIRs with clearly defined specificities, all of the inhibitory kind and all for HLA class I allotypes: KIR2DL2 and KIR2DL3 for HLA-C group 1, KIR2DL1 for HLA-C group 2, KIR3DL1 for HLA-B (Bw4 epitope), KIR3DL2 with HLA-A3 and KIR2DL4 with HLA-G.

In contrast, stimulatory KIR have short cytoplasmic tails lacking ITIM, but have a charged amino acid in the transmembrane region that provides a docking site for the activating adapter molecule DAP12. KIR2DS1 is known to bind HLA-C group 2 and KIR2DS2 binds HLA-C group 1.

REACT_11212 (Reactome) The lectin-like NK cell receptor KLRG1 binds to cadherins on epithelial cells and transmits inhibitory signals to the leukocyte.
REACT_11223 (Reactome) A hallmark of human NK cells is the expression of HLA class I-specific killer-cell immunoglobulin-like receptors (KIR). KIRs are not only variably expressed on the level of single NK cells but they are also highly polymorphic and polygenic (i.e. the gene content of the KIR cluster varies from individual to individual).

There are 15 functional KIR genes known to date, 11 encoding receptors with two immunoglobulin domains (KIR2D genes) and 4 with three domains (KIR3D genes). Inhibitory KIR genes are characterized by long cytoplasmic tails featuring immunoreceptor tyrosine-based inhibitory motifs (ITIM), which upon engagement transmit inhibitory signals leading to the general shutdown of NK cell effector functions. There are six inhibitory KIRs with clearly defined specificities, all of the inhibitory kind and all for HLA class I allotypes: KIR2DL2 and KIR2DL3 for HLA-C group 1, KIR2DL1 for HLA-C group 2, KIR3DL1 for HLA-B (Bw4 epitope), KIR3DL2 with HLA-A3 and KIR2DL4 with HLA-G.

In contrast, stimulatory KIR have short cytoplasmic tails lacking ITIM, but have a charged amino acid in the transmembrane region that provides a docking site for the activating adapter molecule DAP12. KIR2DS1 is known to bind HLA-C group 2 and KIR2DS2 binds HLA-C group 1.

REACT_11230 (Reactome) L-selectin plays a major role in leukocyte traffic through lymph node high endothelial venules.

Both MAdCAM and GlyCAM-1 are major L-selectin ligands produced by these venules and mediate leukocyte rolling, particularly in lymphocytes. They are also expressed in mammary tissue and play an important role in the transfer of immune cells into milk secretions.

The adhesive properties of CD34 and its potential role in homing lymphocytes to lymphoid tissues mimics the mechanims leukocytes adopt to travel to inflammatory sites.

REACT_11239 (Reactome) NK cells express adhesion molecules that allow interaction with their tumour targets, promoting their lysis.

For instance, the activating receptor CD226 is known to be involved in cytotoxic lymphocyte formation, as well as platelet adhesion to the endothelium. The cytoplasmic domain of CD226 contains binding motifs for members of the band 4.1 family of proteins, and for members of the membrane-associated guanylate kinase homolog (MAGUK) family. These proteins connect the CD226 receptor to the cytoskeleton and may promote clustering with LFA-1 integrin (also discussed in this pathway), which is known to participate in CD226's signaling cascade. CD226 plays a role in transendothelial migration, where it facilitates adherence to endothelial cells and migration between cell junctions.

Nectin-2 binds CD226. It is ubiquitously expressed in cells of various tissues, especially in epithelial cells, neurons and fibroblasts. Like many other nectin and Necl proteins, nectin-2 serves as a viral entry receptor for alpha-herpesviruses including herpes simplex virus (HSV-1 and HSV-2). The other CD226 ligand, Necl-5, was initially identified as a receptor for poliovirus.

CD96, another ligand for Necl-5, is strongly upregulated in activated NK cells.

CRTAM is similarly up-regulated, and has been shown to to bind Necl-2, promoting NK cell cytotoxicity towards otherwise poorly immunogenic targets.

REACT_11241 (Reactome) CD40 is a member of the Tumour Necrosis Factor receptor family and its ligand CD40L is a type II transmembrane protein of the TNF superfamily. The latter is expressed preferentially on T-cells and platelets. In the immune system, CD40-CD40L interaction affects some key processes such as immune cell activation, differentiation, proliferation, and apoptosis. CD40-CD40L interaction also upregulates costimulatory molecules (ICAM-1, VCAM-1, E-selectin, LFA-3, B7.1, B7.2, class II MHC, and CD40 itself).
SELLREACT_11230 (Reactome)
T-cell receptor complex with CD8REACT_11080 (Reactome)
VCAM1REACT_11161 (Reactome)
VLA-4REACT_11161 (Reactome)

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