TCA cycle (Krebs cycle) (Arabidopsis thaliana)

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MitochondrionSuccinyl-CoAisocitrate dehydrogenase 1isocitratecitrate synthase 5PiFAD+succinyl-CoA synthetase alpha-1citratesuccinate dehydrogenase FeS 1aconitase 2fumarate2-oxoglutarateFADH2pyruvate dehydrogenase alpha-1succinateH2Omalic enzyme 2GlycolysisAcetyl-CoAoxaloacetatemalate dehydrogenase 2fumaraseCoA2-oxoglutarate dehydrogenasepyruvateCoACO2NAD+NADHNAD+NADHCoACO2NAD+NADHCoAH2OATPADPmalateH2ONAD+NADHNAD+NADHisocitrateisocitrate dehydrogenase2-oxoglutarateNADP+NADPHCO2CO2Glutamate BiosynthesisCO2malic enzyme 1pyruvate dehydrogenase alpha-2pyruvate dehydrogenase beta-1malate dehydrogenase 1citrate synthase 4aconitase 1aconitase 3isocitrate dehydrogenase 2isocitrate dehydrogenase 3isocitrate dehydrogenase 4isocitrate dehydrogenase 5isocitrate dehydrogenase 62-oxoglutarate dehydrogenasesuccinyl-CoA synthetase alpha-2succinyl-CoA synthetase betasuccinate dehydrogenase FeS 2succinate dehydrogenase FeS 3succinate dehydrogenase 1succinate dehydrogenase 2


Description

This pathway describes TCA cycle (Krebs Cycle) reactions in A. thaliana mitochondria.The metabolic links with the Glycolysis and Glutamate Biosynthesis are indicated. Protein identifiers for A. thaliana are from UNIPROT. The pathway is inspired from information drawn for Plant Physiology (Taiz and Zeiger) Third Edition and KEGG Pathways.

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Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
123106view14:53, 3 July 2022EgonwMade a pathway clickable
117252view10:00, 19 May 2021EweitzModified title
111813view19:05, 8 September 2020EgonwCorrected the data source to match the identifier
105902view11:36, 16 August 2019MkutmonHMDB identifier normalization
79786view15:54, 16 April 2015Mkutmonfixed unconnected line
78386view10:22, 7 January 2015MaintBotadded missing graphIds
76230view13:45, 19 June 2014SbohlerAll protein nodes are now annotated with UNIPROT IDs. Information about protein isoforms has been added.
75332view14:48, 19 May 2014SbohlerCorrected translation destination of NAD-ME1 and 2.
75325view13:35, 19 May 2014SbohlerAdapted font of "Mitochondrion" to match other pathways from same authors. Added RNA for CICDH.
75323view13:10, 19 May 2014SbohlerAdded cell border, organelle label and mRNAs for NAD-ME1 and NAD-ME2
74204view07:28, 5 April 2014EgonwRemoved a data source where no ID was given.
73921view10:09, 4 March 2014Anwesha
73920view10:08, 4 March 2014AnweshaModified description
73919view09:59, 4 March 2014SbohlerModified description
73917view09:52, 4 March 2014AnweshaAdded metabolite identifiers
73910view09:03, 4 March 2014Anweshaadded metabolite and pathway identifiers
73909view09:01, 4 March 2014AnweshaPeriodical save, work in progress
73908view08:51, 4 March 2014AnweshaPeriodical save, work in progress
73882view21:55, 26 February 2014MaintBotOntology Term : 'citric acid cycle pathway' added !
73877view21:45, 26 February 2014MaintBotFixed scaling issue
73609view13:43, 4 February 2014Sbohlerremoval of excess objects
73608view13:23, 4 February 2014AnweshaNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2-oxoglutarate dehydrogenaseProteinF4IWV2 (Uniprot-TrEMBL)
2-oxoglutarate dehydrogenaseProteinQ9FLH2 (Uniprot-TrEMBL)
2-oxoglutarateMetaboliteC00026 (KEGG Compound)
ADPMetaboliteC00008 (KEGG Compound)
ATPMetaboliteHMDB00538 (HMDB)
Acetyl-CoAMetaboliteHMDB01206 (HMDB)
CO2MetaboliteHMDB01967 (HMDB)
CoAMetaboliteC00010 (KEGG Compound)
FAD+MetaboliteHMDB01248 (HMDB)
FADH2MetaboliteHMDB01197 (HMDB)
Glutamate BiosynthesisPathway
GlycolysisPathwayWP2621 (WikiPathways)
H2OMetabolite
H2OMetaboliteHMDB02111 (HMDB)
NAD+MetaboliteHMDB00902 (HMDB)
NADHMetaboliteHMDB01487 (HMDB)
NADP+MetaboliteHMDB00902 (HMDB)
NADPHMetaboliteHMDB01487 (HMDB)
PiMetabolite
Succinyl-CoAMetaboliteHMDB01022 (HMDB)
aconitase 1ProteinQ42560 (Uniprot-TrEMBL)
aconitase 2ProteinQ9SIB9 (Uniprot-TrEMBL)
aconitase 3ProteinQ94A28 (Uniprot-TrEMBL)
citrate synthase 4ProteinP20115 (Uniprot-TrEMBL)
citrate synthase 5ProteinQ9M1D3 (Uniprot-TrEMBL)
citrateMetaboliteC00158 (KEGG Compound)
fumaraseProteinP93033 (Uniprot-TrEMBL)
fumarateMetaboliteC00122 (KEGG Compound)
isocitrate dehydrogenase 1ProteinQ8LFC0 (Uniprot-TrEMBL)
isocitrate dehydrogenase 2ProteinP93032 (Enzyme Nomenclature)
isocitrate dehydrogenase 3ProteinO81796 (Uniprot-TrEMBL)
isocitrate dehydrogenase 4ProteinQ9LQK9 (Uniprot-TrEMBL)
isocitrate dehydrogenase 5ProteinQ945K7 (Uniprot-TrEMBL)
isocitrate dehydrogenase 6ProteinQ8LG77 (Uniprot-TrEMBL)
isocitrate dehydrogenaseProteinQ9SRZ6 (Uniprot-TrEMBL)
isocitrateMetaboliteC00311 (KEGG Compound)
malate dehydrogenase 1ProteinQ9ZP06 (Uniprot-TrEMBL)
malate dehydrogenase 2ProteinQ9LKA3 (Uniprot-TrEMBL)
malateMetaboliteC00149 (KEGG Compound)
malic enzyme 1ProteinQ9SIU0 (Uniprot-TrEMBL)
malic enzyme 2ProteinQ8L7K9 (Uniprot-TrEMBL)
oxaloacetateMetaboliteC00036 (KEGG Compound)
pyruvate dehydrogenase alpha-1ProteinP52901 (Uniprot-TrEMBL)
pyruvate dehydrogenase alpha-2ProteinQ8H1Y0 (Uniprot-TrEMBL)
pyruvate dehydrogenase beta-1ProteinQ38799 (Uniprot-TrEMBL)
pyruvateMetaboliteCHEBI:15361 (ChEBI)
succinate dehydrogenase 1ProteinO82663 (Uniprot-TrEMBL)
succinate dehydrogenase 2ProteinQ9ZPX5 (Uniprot-TrEMBL)
succinate dehydrogenase FeS 1ProteinQ8LBZ7 (Uniprot-TrEMBL)
succinate dehydrogenase FeS 2ProteinQ8LB02 (Uniprot-TrEMBL)
succinate dehydrogenase FeS 3ProteinQ9FJP9 (Uniprot-TrEMBL)
succinateMetaboliteC00042 (KEGG Compound)
succinyl-CoA synthetase alpha-1ProteinP68209 (Uniprot-TrEMBL)
succinyl-CoA synthetase alpha-2ProteinQ8LAD2 (Uniprot-TrEMBL)
succinyl-CoA synthetase betaProteinO82662 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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