Nucleosome assembly (Homo sapiens)

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Bibliography

1. Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW.; ''The human CENP-A centromeric nucleosome-associated complex.''; PubMed Europe PMC Scholia
2. Foltz DR, Jansen LE, Bailey AO, Yates JR, Bassett EA, Wood S, Black BE, Cleveland DW.; ''Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP.''; PubMed Europe PMC Scholia
3. Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K.; ''Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase.''; PubMed Europe PMC Scholia
4. Mellone BG, Zhang W, Karpen GH.; ''Frodos found: Behold the CENP-a "Ring" bearers.''; PubMed Europe PMC Scholia
5. Barnhart MC, Kuich PH, Stellfox ME, Ward JA, Bassett EA, Black BE, Foltz DR.; ''HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore.''; PubMed Europe PMC Scholia
6. Dunleavy EM, Roche D, Tagami H, Lacoste N, Ray-Gallet D, Nakamura Y, Daigo Y, Nakatani Y, Almouzni-Pettinotti G.; ''HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres.''; PubMed Europe PMC Scholia
7. Shuaib M, Ouararhni K, Dimitrov S, Hamiche A.; ''HJURP binds CENP-A via a highly conserved N-terminal domain and mediates its deposition at centromeres.''; PubMed Europe PMC Scholia
8. Perpelescu M, Nozaki N, Obuse C, Yang H, Yoda K.; ''Active establishment of centromeric CENP-A chromatin by RSF complex.''; PubMed Europe PMC Scholia
9. Carroll CW, Silva MC, Godek KM, Jansen LE, Straight AF.; ''Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N.''; PubMed Europe PMC Scholia
10. Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T.; ''The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres.''; PubMed Europe PMC Scholia
11. Fujita Y, Hayashi T, Kiyomitsu T, Toyoda Y, Kokubu A, Obuse C, Yanagida M.; ''Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1.''; PubMed Europe PMC Scholia
12. Hayashi T, Fujita Y, Iwasaki O, Adachi Y, Takahashi K, Yanagida M.; ''Mis16 and Mis18 are required for CENP-A loading and histone deacetylation at centromeres.''; PubMed Europe PMC Scholia
13. Maddox PS, Hyndman F, Monen J, Oegema K, Desai A.; ''Functional genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin.''; PubMed Europe PMC Scholia
14. Carroll CW, Milks KJ, Straight AF.; ''Dual recognition of CENP-A nucleosomes is required for centromere assembly.''; PubMed Europe PMC Scholia

History

External references

DataNodes

Name	Type	Database reference	Comment
CASC5 [nucleoplasm]	Protein	Q8NG31 (Uniprot-TrEMBL)
CENPA [nucleoplasm]	Protein	P49450 (Uniprot-TrEMBL)
CENPH [nucleoplasm]	Protein	Q9H3R5 (Uniprot-TrEMBL)
CENPI [nucleoplasm]	Protein	Q92674 (Uniprot-TrEMBL)
CENPK [nucleoplasm]	Protein	Q9BS16 (Uniprot-TrEMBL)
CENPN [nucleoplasm]	Protein	Q96H22 (Uniprot-TrEMBL)
CENPO [nucleoplasm]	Protein	Q9BU64 (Uniprot-TrEMBL)
CENPP [nucleoplasm]	Protein	Q6IPU0 (Uniprot-TrEMBL)
CENPQ [nucleoplasm]	Protein	Q7L2Z9 (Uniprot-TrEMBL)
Centromeric Chromatin: New CENPA Nucleosome:Mis18:HJURP Complex	Complex	REACT_23327 (Reactome)
Centromeric Chromatin:CENPH-I Complex	Complex	REACT_22632 (Reactome)	The mechanism of interaction between the CENPH-I Complex and the centromeric nucleosome (containing CENPA) is unknown. The CENH-I complex is observed to interact with the centromeric core throughout the cell cycle.
Centromeric Chromatin:CENPH-I: Mis18 Complex	Complex	REACT_22736 (Reactome)	The Mis18 complex binds the centromere in late telophase/early G1 phase. The mechanism of interaction between the Mis18 complex and the centromeric core is unknown.
Centromeric Chromatin:CENPH-I:Centromeric Nucleosome:RSF Complex	Complex	REACT_23201 (Reactome)
Centromeric Chromatin:CENPH-I:Mis18:HJURP:CENPA Complex	Complex	REACT_23362 (Reactome)
HIST1H4A [nucleoplasm]	Protein	P62805 (Uniprot-TrEMBL)
HJURP [nucleoplasm]	Protein	Q8NCD3 (Uniprot-TrEMBL)
HJURP:CENPA Complex	Complex	REACT_22554 (Reactome)
Histone H2A	Protein	REACT_8447 (Reactome)
Histone H2B	Protein	REACT_8092 (Reactome)
ITGB3BP [nucleoplasm]	Protein	Q13352 (Uniprot-TrEMBL)
MIS18A [nucleoplasm]	Protein	Q9NYP9 (Uniprot-TrEMBL)
MIS18BP1 [nucleoplasm]	Protein	Q6P0N0 (Uniprot-TrEMBL)
MLF1IP [nucleoplasm]	Protein	Q71F23 (Uniprot-TrEMBL)
Mis18 Complex	Complex	REACT_22768 (Reactome)
NPM1 [nucleoplasm]	Protein	P06748 (Uniprot-TrEMBL)
OIP5 [nucleoplasm]	Protein	O43482 (Uniprot-TrEMBL)
RBBP4 [nucleoplasm]	Protein	Q09028 (Uniprot-TrEMBL)
RBBP7 [nucleoplasm]	Protein	Q16576 (Uniprot-TrEMBL)
RSF Complex	Complex	REACT_22664 (Reactome)
RSF1 [nucleoplasm]	Protein	Q96T23 (Uniprot-TrEMBL)
RUVBL1 [nucleoplasm]	Protein	Q9Y265 (Uniprot-TrEMBL)
SMARCA5 [nucleoplasm]	Protein	O60264 (Uniprot-TrEMBL)

Annotated Interactions

Source	Target	Type	Database reference	Comment
	Centromeric Chromatin: New CENPA Nucleosome:Mis18:HJURP Complex	Arrow	REACT_22185 (Reactome)
Centromeric Chromatin:CENPH-I Complex			REACT_22169 (Reactome)
	Centromeric Chromatin:CENPH-I: Mis18 Complex	Arrow	REACT_22169 (Reactome)
Centromeric Chromatin:CENPH-I: Mis18 Complex			REACT_22146 (Reactome)
	Centromeric Chromatin:CENPH-I:Centromeric Nucleosome:RSF Complex	Arrow	REACT_22217 (Reactome)
Centromeric Chromatin:CENPH-I:Centromeric Nucleosome:RSF Complex			REACT_22185 (Reactome)
	Centromeric Chromatin:CENPH-I:Mis18:HJURP:CENPA Complex	Arrow	REACT_22146 (Reactome)
Centromeric Chromatin:CENPH-I:Mis18:HJURP:CENPA Complex			REACT_22217 (Reactome)
HJURP:CENPA Complex			REACT_22146 (Reactome)
Histone H2A			REACT_22185 (Reactome)
Histone H2B			REACT_22185 (Reactome)
Mis18 Complex			REACT_22169 (Reactome)
			REACT_22146 (Reactome)	The HJURP complex binds free, newly synthesized CENPA-H4 tetramers. A direct interaction occurs between HJURP and CENPA. The CATD domain of CENPA is sufficient for the interaction. The complex then localizes to the centromere in early G1 phase. HJURP is required for deposition of new CENPA-containing nucleosomes.
			REACT_22169 (Reactome)	The Mis18 complex (containing Mis18-alpha, Mis18-beta, Mis18BP1, RBap46, and RbAp48) transiently binds the centromere in late anaphase-telophase to early G1. The mechanism by which the Mis18 complex binds the centromere is unknown. The Mis18 complex is required for deposition of new CENPA-containing nucleosomes at the centromere. The CENPH-I complex is constitutively associated with centromeres and is required for deposition of new CENPA-containing nucleosomes.
			REACT_22185 (Reactome)	A new centromeric nucleosome containing histone H2A, histone H2B, histone H4, and CENPA is deposited at the centromere in late telophase/early G1 phase. The exact mechanism by which the new CENPA-containing nucleosome is transferred to DNA is unknown. HJURP directly binds newly synthesized CENPA before deposition. The Mis18 and HJURP complexes are required for deposition of newly synthesized CENPA-containing nucleosomes. The exact stoichiometries and interactions of the complexes are unknown.
			REACT_22217 (Reactome)	The RSF complex binds the centromere in mid-G1 phase after deposition of new CENPA-containing nucleosomes has occurred. The RSF complex is required for stable incorporation of the previously deposited CENPA-containing nucleosomes.
RSF Complex			REACT_22217 (Reactome)