Signaling by the B Cell Receptor (BCR) (Homo sapiens)

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46, 53, 72, 8529, 83, 13019, 32, 143, 1446, 11, 25, 37, 56...2859, 66, 76, 82, 84...10, 69, 80, 114, 119...12, 64, 70, 13510, 69, 80, 114, 119...9, 86, 89, 101, 1131, 78, 1253, 27, 2812, 20, 62, 64, 73...29, 83, 1304, 38, 48, 57, 90...22, 100, 121, 13324, 74, 87, 115, 1241, 67, 78, 125, 1345, 22, 34, 36, 50...8, 30, 55, 109, 1293, 27, 45, 92, 952, 35, 55, 122, 12814, 21, 41, 46, 53...7, 11, 16, 17, 25...39, 47, 107, 13821, 41, 70, 94, 97...13, 33, 40, 44, 96...28, 45, 93ImmunoglobulinLambda Light Chain[plasma membrane]p-IKBalpha/beta/epsilon[cytosol]Ig Lamda Light ChainV Region [plasmamembrane]NF-kappaB p65:p65[nucleoplasm]p-BLNK:GRB2:SOS1:CIN85:CBL[plasma membrane]26S proteasome[cytosol]p-BTK:PIP3 [plasmamembrane]Calcineurin:PhosphorylatedNFATC1/2/3 [cytosol]Immunoglobulin KappaLight Chain [plasmamembrane]Ig Kappa Light ChainV Region [plasmamembrane]Immunoglobulin KappaLight Chain [plasmamembrane]Ig Antibody LightChain [plasmamembrane]IgD [plasmamembrane]Antigen:p-BCR[plasma membrane]Calcineurin (CaN)[cytosol]IKKA:IKKB:NEMO[plasma membrane]IgM [plasmamembrane]Antigen:BCR [plasmamembrane]Immunoglobulin KappaLight Chain [plasmamembrane]BCAP Signalosome[plasma membrane]Ig Lamda Light ChainV Region [plasmamembrane]NF-kappaBp50/p65/c-Rel Dimer[cytosol]Ig Kappa Light ChainV Region [plasmamembrane]NF-kappaB p50:p50[cytosol]CARMA1:MALT1:BCL10[plasma membrane]Immunoglobulin KappaLight Chain [plasmamembrane]NF-kappaB p65:p65[cytosol]IKKA:IKKB:NEMO[cytosol]NF-kappaBp50:c-Rel:ub-p-IKB[cytosol]NF-kappaB p65:p65[cytosol]NF-kappaBp50:c-Rel:p-IKB[cytosol]NF-kappaB:p-IkB:SCF-betaTrCP[cytosol]p-BCR [plasmamembrane]Ig Lamda Light ChainV Region [plasmamembrane]CD19:VAV1 [plasmamembrane]NF-kappaBp50/p65/c-Rel Dimer[nucleoplasm]Activated PKC beta[plasma membrane]NF-kappaB p50:p50[cytosol]Active Calmodulin[cytosol]CARMA1:BCL10:MALT1:TAK1:IKK[plasma membrane]p21 RAS [plasmamembrane]IgM [plasmamembrane]NF-kappaBp65:p65:IKB[cytosol]IP3 receptors[endoplasmicreticulum membrane]IgM or IgD [plasmamembrane]p-CARMA1 Oligomer[plasma membrane]p-CARMA1 Oligomer[plasma membrane]nucleoplasmNF-kappaB p50:c-Rel[nucleoplasm]IgM Heavy Chain[plasma membrane]IKBalpha/beta/epsilon[cytosol]Calcineurin:Calmodulin(CaN:CaM) [cytosol]Antigen:p-BCR[plasma membrane]NF-kappaBp50/p65/c-Rel:ub-p-IKB[cytosol]NF-kappaBp65:p65:p-IKB[cytosol]PIK3CD:PIK3R1[plasma membrane]IgM Heavy Chain[plasma membrane]IgD Heavy Chain[plasma membrane]IgM [plasmamembrane]p21 RAS:GDP [plasmamembrane]NF-kB complex[cytosol]p-IKBalpha/beta/epsilon[cytosol]IgM Heavy Chain[plasma membrane]Ig Lamda Light ChainV Region [plasmamembrane]NF-kappaB p50:p50[cytosol]CARMA1 oligomer[cytosol]IgD [plasmamembrane]IgM [plasmamembrane]Antigen:p-BCR:SYK[plasma membrane]PIK3CD:PIK3R1[plasma membrane]NF-kappaB p50:p50[cytosol]IgM or IgD [plasmamembrane]NF-KappaBp50:p50:p-IKBA[cytosol]IgD [plasmamembrane]IgD Heavy Chain[plasma membrane]NF-kappaBp65:p65:ub-p-IkB[cytosol]PPP3CA/B [cytosol]BCR [plasmamembrane]Active Calmodulin[cytosol]Ig Lambda C region[plasma membrane]p-BCR [plasmamembrane]STIM1:Calcium[endoplasmicreticulum membrane]plasma membraneNF-kappaB p50:c-Rel[cytosol]Immunoglobulin KappaLight Chain [plasmamembrane]Ig Lamda Light ChainV Region [plasmamembrane]IgD [plasmamembrane]NF-KappaBp50:p50:IKBA[cytosol]PPP3CA/B:Calmodulin[cytosol]Ig Lambda C region[plasma membrane]p-BAM32:PIP3 [plasmamembrane]IgM Heavy Chain[plasma membrane]NF-kappaBp65:p65:p-IKB[cytosol]PIK3CD:PIK3R1[cytosol]Ig Heavy Chain VRegion [plasmamembrane]NF-kappaB p65:p65[cytosol]NF-kappaB p50:c-Rel[cytosol]NF-kappaBp50:p65:p-IKB[cytosol]Orai1 dimer [plasmamembrane]NF-kappaB p50:c-Rel[cytosol]cytosolSCF-beta-TrCP1complex [cytosol]Ig Heavy Chain VRegion [plasmamembrane]SCF-beta-TrCp1/2[cytosol]Ig Antibody LightChain [plasmamembrane]IP3 receptorhomotetramer[endoplasmicreticulum membrane]IgM [plasmamembrane]ImmunoglobulinLambda Light Chain[plasma membrane]Orai1 dimer [plasmamembrane]Ig Heavy Chain VRegion [plasmamembrane]Ig Lambda C region[plasma membrane]NF-kappaB p65:p65[cytosol]Active IKK complex[cytosol]NF-kappa-B p50/p65/c-Rel:p-IKB[cytosol]IgM Heavy Chain[plasma membrane]CyclophilinA:Cyclosporin A[cytosol]IgD Heavy Chain[plasma membrane]Ig Antibody LightChain [plasmamembrane]SCF-beta-TrCp1/2[cytosol]IP3 receptorhomotetramer[endoplasmicreticulum membrane]endoplasmic reticulum lumenAntigen:p-BCR:p-SYK:p-BLNK[plasma membrane]Immunoglobulin KappaLight Chain [plasmamembrane]Ig Lambda C region[plasma membrane]NF-kB complex[cytosol]BCR [plasmamembrane]BLNK (SLP-65)Signalosome [plasmamembrane]IgM or IgD [plasmamembrane]Antigen:p-BCR[plasma membrane]PIK3CD:PIK3R1[plasma membrane]p-CARMA1 Oligomer[plasma membrane]p-BCR [plasmamembrane]ub-p-IKBalpha/beta/epsilon[cytosol]NF-kappaB p50:c-Rel[cytosol]Ig Kappa Light ChainV Region [plasmamembrane]p21 RAS:GTP [plasmamembrane]IgM [plasmamembrane]p-CARMA1 Oligomer[plasma membrane]IgM Heavy Chain[plasma membrane]NF-kappaBp50:p65:ub-p-IKB[cytosol]SCF-beta-TrCP1complex [cytosol]IP3 receptors[endoplasmicreticulum membrane]STIM1 Dimer[endoplasmicreticulum membrane]NF-kappaBp50:c-Rel:p-IKB[cytosol]IgD [plasmamembrane]Ig Antibody LightChain [plasmamembrane]Ig Kappa Light ChainV Region [plasmamembrane]SCF-beta-TrCP2complex [cytosol]SCF-beta-TrCP2complex [cytosol]IgD [plasmamembrane]Ig Antibody LightChain [plasmamembrane]Antigen:p-BCR:p-SYK:p-BLNK[plasma membrane]FKBP1A:Tacrolimus[cytosol]Ig Antibody LightChain [plasmamembrane]Calcineurin alpharegulatorysubunit:Calcium[cytosol]IgD Heavy Chain[plasma membrane]IgD [plasmamembrane]IP3 receptor:IP3complex [endoplasmicreticulum membrane]p-BCR [plasmamembrane]STIM1 Dimer[endoplasmicreticulum membrane]Antigen:p-BCR:p-SYK[plasma membrane]STIM1 Dimer[endoplasmicreticulum membrane]Ig Heavy Chain VRegion [plasmamembrane]NF-KappaBp50:p50:ub-p-IKBA[cytosol]PPP3CA/B:Fe3+:Zn2+[cytosol]Ig Kappa Light ChainV Region [plasmamembrane]ImmunoglobulinLambda Light Chain[plasma membrane]BLNK:GRB2:SOS1:CIN85:CBL[cytosol]CARMA1:BCL10:MALT1:TAK1[plasma membrane]STIM1:TRPC1[endoplasmicreticulum membrane,plasma membrane]IgM [plasmamembrane]NF-kappaB p50:p50[nucleoplasm]p21 RAS [plasmamembrane]p-PLC gamma1/2[plasma membrane]p-PLC gamma1,2:PIP3[plasma membrane]Ig Heavy Chain VRegion [plasmamembrane]ImmunoglobulinLambda Light Chain[plasma membrane]NF-kappaB p50:c-Rel[cytosol]CRAC channel [plasmamembrane]Ig Heavy Chain VRegion [plasmamembrane]PPP3CA/B [cytosol]Antigen:p-BCR:p-SYK[plasma membrane]ImmunoglobulinLambda Light Chain[plasma membrane]NF-kappaB p65:p65[cytosol]Ig Kappa Light ChainV Region [plasmamembrane]Ig Lambda C region[plasma membrane]CARMA1:MALT1:BCL10[plasma membrane]NF-kappaBp50:p65:p-IKB[cytosol]p-RasGRP1,3:DAG[plasma membrane]CARMA1:MALT1:BCL10[plasma membrane]NF-kB complex[cytosol]p-SHC1 p46/p52[plasma membrane]Antigen:p-BCR[plasma membrane]NF-kappaB p50:p50[cytosol]Antigen:p-BCR:p-SYK[plasma membrane]Ig Kappa Light ChainV Region [plasmamembrane]NF-kappa-Bp50,/p65,/c-Rel:IKB[cytosol]IgM Heavy Chain[plasma membrane]Ig Heavy Chain VRegion [plasmamembrane]NF-kB complex[cytosol]IgM or IgD [plasmamembrane]NF-KappaBp50:p50:p-IKBA[cytosol]IgD Heavy Chain[plasma membrane]IgD Heavy Chain[plasma membrane]p-BLNK:GRB2:SOS1:CIN85:CBL[plasma membrane]NF-kappaBp50:c-Rel:IkB[cytosol]NF-kappa-B p50/p65/c-Rel:p-IKB[cytosol]p-RasGRP1/3 [plasmamembrane]p-BCR [plasmamembrane]CD19 Signalosome[plasma membrane]NF-kB complex[nucleoplasm]Ig Lambda C region[plasma membrane]PPP3CA/B:Fe3+:Zn2+[cytosol]Ig Lamda Light ChainV Region [plasmamembrane]NF-kB complex[cytosol]IgM or IgD [plasmamembrane]Antigen:p-BCR[plasma membrane]NF-kappaBp50:p65:IKB[cytosol]IgD Heavy Chain[plasma membrane]Immunoglobulin KappaLight Chain [plasmamembrane]PhosphorylatedNFATC1/2/3 [cytosol]Ig Lambda C region[plasma membrane]IgM or IgD [plasmamembrane]ImmunoglobulinLambda Light Chain[plasma membrane]Ig Antibody LightChain [plasmamembrane]ImmunoglobulinLambda Light Chain[plasma membrane]Ig Lamda Light ChainV Region [plasmamembrane]IgM or IgD [plasmamembrane]UbIg heavy chain V-IIIregion JON [plasmamembrane]Ig kappa chain V-Iregion WAT [plasmamembrane]Ig lambda chain V-Iregion NEWM [plasmamembrane]Ig kappa chain V-Iregion DEE [plasmamembrane]PSMD8 [cytosol]IGKC(1-106) [plasmamembrane]Ig lambda chain V-Iregion NEW [plasmamembrane]IGKVA18(21-?)[plasma membrane]Ig lambda chain V-Iregion MEM [plasmamembrane]Ig heavy chain V-IIIregion WEA [plasmamembrane]Ig heavy chain V-IIIregion TEI [plasmamembrane]Ig heavy chain V-Iregion SIE [plasmamembrane]p-Y771,Y783-PLCG1[plasma membrane]Ig kappa chain V-Iregion WEA [plasmamembrane]Ig heavy chain V-IIIregion BUR [plasmamembrane]Ig lambda chain V-IIregion BUR [plasmamembrane]Ig kappa chain V-Iregion EU [plasmamembrane]Ig kappa chain V-IIregion FR [plasmamembrane]Ig heavy chain V-IIIregion BRO [plasmamembrane]Ig kappa chain V-IIregion TEW [plasmamembrane]Ig lambda chain V-IIregion TOG [plasmamembrane]Ig lambda chain V-VIregion NIG-48[plasma membrane]Ig heavy chain V-IIregion WAH [plasmamembrane]Ig lambda chain V-VIregion AR [plasmamembrane]IGLC2(?-106) [plasmamembrane]Ig kappa chain V-IVregion B17 [plasmamembrane]Ig kappa chain V-IVregion Len [plasmamembrane]Ig kappa chain V-IIIregion VH [plasmamembrane]IgH heavy chainV-III region VH26precursor [plasmamembrane]PI(4,5)P2SH3KBP1 [plasmamembrane]Ig kappa chain V-IIregion FR [plasmamembrane]p-S157,S161-NFKBIE[cytosol]Ig heavy chain V-IIIregion WAS [plasmamembrane]Ig lambda chain V-IVregion Hil [plasmamembrane]Ig lambda chainV-III region LOI[plasma membrane]Ig lambda chain V-IIregion NEI [plasmamembrane]MALT1 [plasmamembrane]Ig kappa chain V-IVregion Len [plasmamembrane]Calcineurin:PhosphorylatedNFATC1/2/3PIK3CD:PIK3R1p-S177,S181-IKBKB[cytosol]Ig heavy chain V-IIregion WAH [plasmamembrane]Ig lambda chain V-Iregion NEWM [plasmamembrane]Ig kappa chain V-IVregion JI [plasmamembrane]Ig heavy chain V-IIIregion TIL [plasmamembrane]Ig kappa chain V-IIregion Cum [plasmamembrane]Ig kappa chain V-IIIregion CLL [plasmamembrane]STIM1 [endoplasmicreticulum membrane]Ig kappa chain V-IIIregion POM [plasmamembrane]IGLC7(?-106) [plasmamembrane]Ig heavy chain V-Iregion ND [plasmamembrane]PPP3R1 [cytosol]PIK3R1 [plasmamembrane]Ig kappa chain V-Iregion BAN [plasmamembrane]Ig lambda chain V-Iregion NEW [plasmamembrane]PSMA7(2-248)[cytosol]Ig kappa chain V-IVregion JI [plasmamembrane]Ig heavy chain V-IIregion WAH [plasmamembrane]CHUK [cytosol]Ig kappa chain V-IIIregion WOL [plasmamembrane]Ig kappa chain V-IIregion Cum [plasmamembrane]Ig kappa chain V-IIIregion WOL [plasmamembrane]Ig lambda chain V-IIregion TRO [plasmamembrane]Cyclosporin A[cytosol]Ig lambda chain V-Iregion NEWM [plasmamembrane]Ig kappa chain V-Iregion Lay [plasmamembrane]I(1,4,5)P3 [cytosol]Ig heavy chain V-IIIregion KOL [plasmamembrane]CARMA1:BCL10:MALT1:TAK1Ig kappa chain V-IIIregion HAH [plasmamembrane]p-Y223,Y551-BTK[plasma membrane]Ig heavy chain V-IIIregion TRO [plasmamembrane]Fe3+ [cytosol]IGKV4-1(21-?)[plasma membrane]PhosphorylatedNFATC1/2/3BCAP SignalosomeIg lambda chain V-Iregion MEM [plasmamembrane]Ig kappa chain V-Iregion Gal [plasmamembrane]Ig kappa chain V-IVregion Len [plasmamembrane]Ig lambda chain V-Iregion NIG-64[plasma membrane]PSMC5 [cytosol]Ig kappa chain V-IIIregion Ti [plasmamembrane]Ig lambda chain V-IIregion VIL [plasmamembrane]IKBKG [plasmamembrane]p-Y188,Y199-CD79A[plasma membrane]Ig kappa chain V-Iregion Scw [plasmamembrane]Ig kappa chain V-IIregion GM607 [plasmamembrane]DAGIg lambda chain V-Iregion EPS [plasmamembrane]ORAI1 [plasmamembrane]IGKVA18(21-?)[plasma membrane]Ig kappa chain V-IIIregion SIE [plasmamembrane]Ig kappa chain V-Iregion Gal [plasmamembrane]REL [cytosol]REL [nucleoplasm]Ig heavy chain V-IIIregion LAY [plasmamembrane]PSMB3 [cytosol]IGLV(23-?) [plasmamembrane]IGKV4-1(21-?)[plasma membrane]Ig kappa chain V-Iregion Hau [plasmamembrane]Ig lambda chain V-Iregion NEW [plasmamembrane]Ig kappa chain V-IIregion MIL [plasmamembrane]Ig kappa chain V-Iregion Ka [plasmamembrane]IGLC3(?-106) [plasmamembrane]IGLV(23-?) [plasmamembrane]Ig heavy chain V-IIIregion TEI [plasmamembrane]Ig heavy chain V-IIIregion DOB [plasmamembrane]Ig kappa chain V-IIregion GM607 [plasmamembrane]Ig heavy chain V-IIIregion GAL [plasmamembrane]Ig kappa chain V-IIIregion SIE [plasmamembrane]FBXW11 [cytosol]ITPR3 [endoplasmicreticulum membrane]Ig kappa chain V-Iregion Wes [plasmamembrane]Ig kappa chain V-IIIregion IARC/BL41[plasma membrane]Ig lambda chain V-Iregion EPS [plasmamembrane]Ig lambda chain V-VIregion EB4 [plasmamembrane]IGLC6(?-106) [plasmamembrane]Zn2+ [cytosol]Ig heavy chain V-IIregion WAH [plasmamembrane]Ig kappa chain V-IIregion RPMI 6410[plasma membrane]Ig lambda chain V-VIregion EB4 [plasmamembrane]Ig kappa chain V-Iregion Mev [plasmamembrane]IGLC6(?-106) [plasmamembrane]Ig kappa chain V-Iregion Roy [plasmamembrane]IGLC1(1-105) [plasmamembrane]Ig kappa chain V-Iregion CAR [plasmamembrane]Ig heavy chain V-IIIregion GAL [plasmamembrane]PI(4,5)P2Ig heavy chain V-Iregion EU [plasmamembrane]CALM1Ig kappa chain V-Iregion AG [plasmamembrane]TRPC1HRAS(1-186) [plasmamembrane]MALT1 [plasmamembrane]TRPC1 [plasmamembrane]Ig heavy chain V-Iregion EU [plasmamembrane]Ig heavy chain V-IIIregion GA [plasmamembrane]PIK3R1 [plasmamembrane]NRAS [plasmamembrane]Ig heavy chain V-IIIregion BUR [plasmamembrane]Ig lambda chain V-IIregion BUR [plasmamembrane]Ig lambda chain V-VIregion EB4 [plasmamembrane]SOS1 [plasmamembrane]Ig heavy chain V-IIregion COR [plasmamembrane]Ig heavy chain V-IIregion HE [plasmamembrane]Ig kappa chain V-IIIregion VG [plasmamembrane]Ig kappa chain V-IVregion B17 [plasmamembrane]Ig kappa chain V-Iregion DEE [plasmamembrane]Ig heavy chain V-IIregion SESS [plasmamembrane]ATPIg kappa chain V-Iregion Lay [plasmamembrane]Ig kappa chain V-IIIregion WOL [plasmamembrane]PPP3CA [cytosol]Ig heavy chain V-IIregion SESS [plasmamembrane]Ig kappa chain V-IIIregion GOL [plasmamembrane]p-13S-NFATC3[cytosol]Ig kappa chain V-IIIregion POM [plasmamembrane]DAPP1Active CalmodulinIg lambda chainV-III region LOI[plasma membrane]Ig heavy chain V-IIIregion BUR [plasmamembrane]Ig heavy chain V-Iregion WOL [plasmamembrane]Ig kappa chain V-IVregion JI [plasmamembrane]Ig kappa chain V-IIIregion B6 [plasmamembrane]CRAC channelPSMB2 [cytosol]Fe3+ [cytosol]Ig lambda chainV-III region SH[plasma membrane]Ig lambda chain V-VIregion WLT [plasmamembrane]GRB2-1 [cytosol]IGHM(?-452) [plasmamembrane]PSMB1 [cytosol]IGKVA18(21-?)[plasma membrane]IGLV(23-?) [plasmamembrane]IGLC7(?-106) [plasmamembrane]Ig kappa chain V-IIregion GM607 [plasmamembrane]Ig lambda chainV-III region SH[plasma membrane]IGLV(23-?) [plasmamembrane]Ig heavy chain V-IIIregion TEI [plasmamembrane]PSMD1 [cytosol]Ig kappa chain V-IVregion Len [plasmamembrane]NRAS [plasmamembrane]Ig heavy chain V-IIIregion GA [plasmamembrane]Ig heavy chain V-IIIregion ZAP [plasmamembrane]PSMA1 [cytosol]Ig kappa chain V-Iregion Hau [plasmamembrane]p-Y188,Y199-CD79A[plasma membrane]IP3 receptorhomotetramerPSMD7(2-324)[cytosol]Ig kappa chain V-Iregion Ni [plasmamembrane]Ig lambda chain V-IIregion MGC [plasmamembrane]Ig lambda chain V-IIregion NEI [plasmamembrane]Ig kappa chain V-IIIregion VG [plasmamembrane]Ig kappa chain V-IIIregion CLL [plasmamembrane]Ig kappa chain V-IIIregion HAH [plasmamembrane]ATPIg heavy chain V-IIIregion POM [plasmamembrane]Ig heavy chain V-Iregion Mot [plasmamembrane]PIK3CD [plasmamembrane]Ig kappa chain V-IVregion JI [plasmamembrane]Ig kappa chain V-Iregion Kue [plasmamembrane]p-RasGRP1,3:DAGIg lambda chain V-IVregion MOL [plasmamembrane]Ig lambda chain V-IIregion BOH [plasmamembrane]Ig lambda chain V-IIregion BUR [plasmamembrane]p-T133-RASGRP3[plasma membrane]Ig lambda chain V-Iregion EPS [plasmamembrane]Ig lambda chain V-IIregion WIN [plasmamembrane]Ig lambda chain V-IIregion NIG-84[plasma membrane]Ig kappa chain V-IIregion GM607 [plasmamembrane]Ig heavy chain V-Iregion EU [plasmamembrane]Ig kappa chain V-Iregion Wes [plasmamembrane]Ig heavy chain V-IIregion OU [plasmamembrane]Ig heavy chain V-IIregion SESS [plasmamembrane]IgH heavy chainV-III region VH26precursor [plasmamembrane]p-5Y-BLNK [plasmamembrane]Ig kappa chain V-Iregion Roy [plasmamembrane]Ig heavy chain V-IIIregion TIL [plasmamembrane]Ig heavy chain V-IIIregion TIL [plasmamembrane]LYN(2-512)Ig lambda chain V-VIregion SUT [plasmamembrane]Ig lambda chain V-IIregion TRO [plasmamembrane]Ig lambda chainV-III region SH[plasma membrane]RELA [cytosol]IGKV1-5(23-?)[plasma membrane]Ig heavy chain V-IIIregion KOL [plasmamembrane]Ig lambda chain V-IIregion NIG-84[plasma membrane]Ig kappa chain V-Iregion Ka [plasmamembrane]p-S559,S644,S652-CARD11(1-1147)[plasma membrane]Ig lambda chain V-IVregion MOL [plasmamembrane]Ig kappa chain V-Iregion AG [plasmamembrane]SHC1 p46/p52Ig kappa chain V-Iregion Ka [plasmamembrane]Ig heavy chain V-IIIregion TEI [plasmamembrane]p-BCL10BLK(2-505)Ig lambda chain Vregion 4A [plasmamembrane]Ig heavy chain V-IIIregion KOL [plasmamembrane]PPP3R1 [cytosol]IGHV(1-?) [plasmamembrane]Ig kappa chain V-Iregion Daudi [plasmamembrane]PSMB10 [cytosol]PSMB5 [cytosol]RELA [nucleoplasm]Ig kappa chain V-Iregion WAT [plasmamembrane]CHUK [plasmamembrane]Ig kappa chain V-IIregion FR [plasmamembrane]Ig kappa chain V-IIIregion HIC [plasmamembrane]Ig kappa chain V-Iregion OU [plasmamembrane]Ig lambda chain V-IIregion VIL [plasmamembrane]Ig lambda chain V-IIregion NEI [plasmamembrane]Ig kappa chain V-Iregion OU [plasmamembrane]PIK3CD [cytosol]PSMD3 [cytosol]PPP3CB(2-524)[cytosol]Ig kappa chain V-Iregion Mev [plasmamembrane]FYN(2-537)Ig heavy chain V-IIIregion BUT [plasmamembrane]FKBP1A:TacrolimusIg kappa chain V-IIIregion VG [plasmamembrane]Ig heavy chain V-IIregion MCE [plasmamembrane]IKBKG [cytosol]Ig kappa chain V-Iregion HK101 [plasmamembrane]Ig kappa chain V-IIIregion HAH [plasmamembrane]Ig lambda chainV-VII region MOT[plasma membrane]Ig lambda chain V-VIregion AR [plasmamembrane]Ig kappa chain V-IVregion B17 [plasmamembrane]Ig heavy chain V-IIIregion JON [plasmamembrane]CALM1 [cytosol]Ig lambda chainV-VII region MOT[plasma membrane]Ig kappa chain V-IIIregion WOL [plasmamembrane]Ig heavy chain V-IIregion COR [plasmamembrane]Ig heavy chain V-IIregion DAW [plasmamembrane]IGLC7(?-106) [plasmamembrane]PSMD4(2-377)[cytosol]IKBKB [cytosol]Ig kappa chain V-IIIregion B6 [plasmamembrane]Ig heavy chain V-IIIregion TIL [plasmamembrane]p-5Y-BLNK [plasmamembrane]IGKVA18(21-?)[plasma membrane]Ig kappa chain V-Iregion EU [plasmamembrane]Ig kappa chain V-Iregion AG [plasmamembrane]Ig lambda chain V-IVregion X [plasmamembrane]Ig lambda chain V-VIregion SUT [plasmamembrane]Ig lambda chain V-IVregion Hil [plasmamembrane]PIK3R1 [cytosol]Ig lambda chain V-IIregion NEI [plasmamembrane]CALM1 [cytosol]Ig heavy chain V-IIregion ARH-77[plasma membrane]PSME2 [cytosol]Ig kappa chain V-IIregion TEW [plasmamembrane]Ig heavy chain V-IIIregion JON [plasmamembrane]Ig lambda chain V-Iregion NEW [plasmamembrane]Ig kappa chain V-Iregion WEA [plasmamembrane]Ig kappa chain V-IIregion RPMI 6410[plasma membrane]Ig kappa chain V-Iregion Rei [plasmamembrane]Ig kappa chain V-IIregion Cum [plasmamembrane]Ig heavy chain V-IIregion HE [plasmamembrane]Ig heavy chain V-IIregion NEWM [plasmamembrane]PIK3AP1Ig lambda chain V-VIregion WLT [plasmamembrane]Ig heavy chain V-Iregion Mot [plasmamembrane]Ig kappa chain V-Iregion Kue [plasmamembrane]Ig lambda chain V-IVregion X [plasmamembrane]PSME3 [cytosol]Calcineurin (CaN)Ig kappa chain V-IIIregion POM [plasmamembrane]ATPIg lambda chain V-VIregion WLT [plasmamembrane]Ig lambda chain V-Iregion WAH [plasmamembrane]CARMA1:BCL10:MALT1:TAK1:IKKIg lambda chain V-VIregion SUT [plasmamembrane]Ig lambda chain V-VIregion WLT [plasmamembrane]Ig kappa chain V-IVregion B17 [plasmamembrane]Ig heavy chain V-Iregion SIE [plasmamembrane]Ig kappa chain Vregion EV15 [plasmamembrane]Ig lambda chain V-IIregion BOH [plasmamembrane]Ig lambda chain V-IVregion Bau [plasmamembrane]Ig heavy chain V-IIIregion GAL [plasmamembrane]Ig kappa chain V-Iregion AU [plasmamembrane]Ig kappa chain V-Iregion Kue [plasmamembrane]Ig lambda chain V-IIregion NIG-84[plasma membrane]NF-kappaBp50/p65/c-Rel:ub-p-IKBIg kappa chain V-IIIregion GOL [plasmamembrane]CHUK [cytosol]PSMB11 [cytosol]Ig kappa chain V-IVregion JI [plasmamembrane]NFKB1(1-433)[cytosol]IGKC(1-106) [plasmamembrane]Ig lambda chain V-VIregion NIG-48[plasma membrane]Ig heavy chain V-IIIregion KOL [plasmamembrane]Ig heavy chain V-IIIregion NIE [plasmamembrane]Ig heavy chain V-IIIregion GAL [plasmamembrane]Ig kappa chain V-Iregion Wes [plasmamembrane]NF-kappa-B p50/p65/c-Rel:p-IKBIg heavy chain V-Iregion HG3 [plasmamembrane]Ig heavy chain V-IIregion HE [plasmamembrane]Ig heavy chain V-IIIregion TRO [plasmamembrane]ADPIg kappa chain V-IIIregion VG [plasmamembrane]Ig kappa chain V-Iregion Ka [plasmamembrane]PSMD5 [cytosol]IgH heavy chainV-III region VH26precursor [plasmamembrane]Ig kappa chain V-Iregion Rei [plasmamembrane]Ig kappa chain V-Iregion Daudi [plasmamembrane]Ig kappa chain V-Iregion DEE [plasmamembrane]Ig kappa chain V-Iregion WAT [plasmamembrane]Orai1 dimerIg lambda chain V-IVregion MOL [plasmamembrane]Antigen:p-BCR:p-SYK:p-BLNKIg heavy chain V-IIIregion HIL [plasmamembrane]Ig heavy chain V-IIIregion CAM [plasmamembrane]p-6Y-SYK [plasmamembrane]Ig heavy chain V-IIIregion ZAP [plasmamembrane]Ig lambda chain V-Iregion NIG-64[plasma membrane]Ig lambda chain V-VIregion AR [plasmamembrane]Ig kappa chain V-Iregion Daudi [plasmamembrane]Ig lambda chainV-III region SH[plasma membrane]Ig lambda chain V-IVregion Kern [plasmamembrane]Ig kappa chain V-IIIregion B6 [plasmamembrane]Ig kappa chain V-Iregion WEA [plasmamembrane]Ig kappa chain V-Iregion CAR [plasmamembrane]Ig kappa chain V-Iregion BAN [plasmamembrane]Ig heavy chain V-IIIregion HIL [plasmamembrane]Ig heavy chain V-IIIregion LAY [plasmamembrane]RasGRP1/3MALT1GRB2-1Ig heavy chain V-IIregion DAW [plasmamembrane]p-Y196,Y207-CD79B[plasma membrane]Ig kappa chain V-IIIregion GOL [plasmamembrane]IgH heavy chainV-III region VH26precursor [plasmamembrane]Ig heavy chain V-IIregion ARH-77[plasma membrane]Ig kappa chain V-Iregion EU [plasmamembrane]Ig heavy chain V-IIIregion KOL [plasmamembrane]Ig lambda chain V-IIregion BOH [plasmamembrane]Ig heavy chain V-IIIregion CAM [plasmamembrane]IGKC(1-106) [plasmamembrane]IGHV(1-?) [plasmamembrane]IGHV7-81(1-?)[plasma membrane]Ig lambda chain V-Iregion MEM [plasmamembrane]Ig kappa chain V-Iregion Hau [plasmamembrane]Ig heavy chain V-IIIregion ZAP [plasmamembrane]Ig kappa chain V-Iregion CAR [plasmamembrane]Ig lambda chain V-Iregion BL2 [plasmamembrane]IKBKG [cytosol]PPIA [cytosol]Ig kappa chain V-Iregion Rei [plasmamembrane]Ig kappa chain V-Iregion Walker[plasma membrane]Ig heavy chain V-Iregion SIE [plasmamembrane]Ig lambda chain V-IIregion NIG-58[plasma membrane]Ig lambda chain V-IIregion VIL [plasmamembrane]p-S559,S644,S652-CARD11(1-1147)[plasma membrane]Ig kappa chain V-IIregion RPMI 6410[plasma membrane]Ig kappa chain V-Iregion Ka [plasmamembrane]PSMB8 [cytosol]GRB2-1 [plasmamembrane]Ig kappa chain V-Iregion OU [plasmamembrane]STIM1 [endoplasmicreticulum membrane]Ig lambda chain V-IVregion Bau [plasmamembrane]Ig lambda chain V-IIregion WIN [plasmamembrane]Ig heavy chain V-IIregion NEWM [plasmamembrane]Ig heavy chain V-IIIregion BUT [plasmamembrane]DephosphorylatedNFATC1/2/3Ig kappa chain V-Iregion AU [plasmamembrane]Ig lambda chain V-VIregion AR [plasmamembrane]IGLV(23-?) [plasmamembrane]Ig lambda chain V-Iregion HA [plasmamembrane]Ig kappa chain V-Iregion Ni [plasmamembrane]26S proteasomeIg lambda chain V-Iregion WAH [plasmamembrane]VAV1 [plasmamembrane]Ig lambda chainV-III region LOI[plasma membrane]IGLC1(1-105) [plasmamembrane]Ig lambda chain V-IIregion NIG-58[plasma membrane]Ig heavy chain V-Iregion Mot [plasmamembrane]Ig kappa chain V-IIregion MIL [plasmamembrane]Ig kappa chain V-IIIregion Ti [plasmamembrane]p-T187-MAP3K7[plasma membrane]PSMD12 [cytosol]Ig heavy chain V-IIIregion TIL [plasmamembrane]Ig lambda chain V-Iregion VOR [plasmamembrane]Ig heavy chain V-Iregion WOL [plasmamembrane]Ig kappa chain V-Iregion Kue [plasmamembrane]ITPR1 [endoplasmicreticulum membrane]Ig heavy chain V-IIIregion CAM [plasmamembrane]Ig heavy chain V-Iregion WOL [plasmamembrane]Antigen:p-BCRIGLC2(?-106) [plasmamembrane]Ig kappa chain V-IIIregion NG9 [plasmamembrane]Ig kappa chain V-IIIregion CLL [plasmamembrane]p-BCL10 [plasmamembrane]Ig lambda chain V-IVregion Bau [plasmamembrane]Ig lambda chain V-IIregion TRO [plasmamembrane]PSMA5 [cytosol]IGLC1(1-105) [plasmamembrane]Ig heavy chain V-IIIregion TUR [plasmamembrane]DAG [plasmamembrane]Ig lambda chain Vregion 4A [plasmamembrane]Ig heavy chain V-Iregion HG3 [plasmamembrane]Ig lambda chain V-Iregion VOR [plasmamembrane]Ig heavy chain V-Iregion EU [plasmamembrane]Ig kappa chain V-IIIregion POM [plasmamembrane]Ig heavy chain V-IIregion HE [plasmamembrane]Ig lambda chain V-IIregion MGC [plasmamembrane]Ig kappa chain V-Iregion Ka [plasmamembrane]NFKB1(1-433)[cytosol]Ig heavy chain V-Iregion Mot [plasmamembrane]Ig kappa chain V-Iregion OU [plasmamembrane]Ig kappa chain V-Iregion EU [plasmamembrane]SYKIg lambda chain V-IVregion MOL [plasmamembrane]DAG [plasmamembrane]IGLC3(?-106) [plasmamembrane]Ig kappa chain V-Iregion Scw [plasmamembrane]Ig kappa chain V-IIIregion Ti [plasmamembrane]Ig kappa chain V-IIregion MIL [plasmamembrane]Ig heavy chain V-IIIregion HIL [plasmamembrane]IGLC6(?-106) [plasmamembrane]Ig lambda chain V-Vregion DEL [plasmamembrane]FKBP1A [cytosol]Ig lambda chain V-IVregion Kern [plasmamembrane]Ig lambda chain V-VIregion NIG-48[plasma membrane]Ig heavy chain V-IIIregion NIE [plasmamembrane]IGHV7-81(1-?)[plasma membrane]Ig kappa chain V-Iregion WEA [plasmamembrane]Ig heavy chain V-IIIregion TUR [plasmamembrane]IGHD(?-384) [plasmamembrane]Ca2+Ig lambda chain V-IIregion BUR [plasmamembrane]Ig kappa chain V-Iregion AU [plasmamembrane]IgH heavy chainV-III region VH26precursor [plasmamembrane]p-S32,S36-NFKBIA[cytosol]Ig lambda chain V-IIregion BO [plasmamembrane]ITPR3 [endoplasmicreticulum membrane]p-Y196,Y207-CD79B[plasma membrane]IGHD(?-384) [plasmamembrane]Ig heavy chain V-IIregion DAW [plasmamembrane]Ig heavy chain V-IIregion MCE [plasmamembrane]Ig lambda chain V-VIregion NIG-48[plasma membrane]Ig lambda chain V-IIregion VIL [plasmamembrane]Ig kappa chain V-IIIregion CLL [plasmamembrane]PSMD9 [cytosol]Ig lambda chain V-VIregion NIG-48[plasma membrane]Ig kappa chain V-Iregion Scw [plasmamembrane]NFKB1(1-433)[nucleoplasm]Ig kappa chain V-Iregion WAT [plasmamembrane]Ig kappa chain V-Iregion Bi [plasmamembrane]NF-kappa-Bp50,/p65,/c-Rel:IKBIg kappa chain V-Iregion Ni [plasmamembrane]Ig kappa chain V-IIIregion WOL [plasmamembrane]Ig kappa chain V-Iregion WAT [plasmamembrane]Ig heavy chain V-IIIregion BRO [plasmamembrane]IGKV1-5(23-?)[plasma membrane]Ig kappa chain V-Iregion OU [plasmamembrane]Ig lambda chain V-IIregion NEI [plasmamembrane]Ig lambda chain V-IIregion WIN [plasmamembrane]Ca2+Ig heavy chain V-IIIregion BRO [plasmamembrane]p-T187-MAP3K7[plasma membrane]Ig heavy chain V-IIregion WAH [plasmamembrane]Ig heavy chain V-IIregion ARH-77[plasma membrane]Ig kappa chain V-Iregion Mev [plasmamembrane]SCF-beta-TrCp1/2Ig heavy chain V-IIIregion CAM [plasmamembrane]Ig kappa chain V-Iregion Gal [plasmamembrane]Ig lambda chain V-Iregion VOR [plasmamembrane]IGKV1-5(23-?)[plasma membrane]Ig kappa chain V-Iregion OU [plasmamembrane]Antigen:p-BCR:p-SYKIg lambda chain V-Iregion BL2 [plasmamembrane]p-T184-RASGRP1[plasma membrane]IGHV7-81(1-?)[plasma membrane]Ig kappa chain V-IIIregion GOL [plasmamembrane]CARMA1 oligomerIg kappa chain V-IIIregion VG [plasmamembrane]Ig kappa chain V-IIIregion NG9 [plasmamembrane]Ig lambda chain V-IVregion X [plasmamembrane]IGLC7(?-106) [plasmamembrane]Ig heavy chain V-IIIregion DOB [plasmamembrane]Ig heavy chain V-IIIregion TRO [plasmamembrane]p-S559,S644,S652-CARD11(1-1147)[plasma membrane]Ig kappa chain V-Iregion OU [plasmamembrane]ITPR2 [endoplasmicreticulum membrane]Ig heavy chain V-IIregion OU [plasmamembrane]Ig heavy chain V-IIIregion TEI [plasmamembrane]IGHM(?-452) [plasmamembrane]Ig kappa chain V-Iregion Roy [plasmamembrane]Ig kappa chain V-IIregion GM607 [plasmamembrane]Ig kappa chain V-IVregion Len [plasmamembrane]Ig kappa chain V-IVregion STH [plasmamembrane]Ig heavy chain V-IIregion COR [plasmamembrane]Ig heavy chain V-Iregion WOL [plasmamembrane]VAV1Ig kappa chain V-IIIregion POM [plasmamembrane]Ig kappa chain V-IVregion STH [plasmamembrane]Ig kappa chain V-Iregion AG [plasmamembrane]Ig lambda chain V-VIregion WLT [plasmamembrane]STIM1 [endoplasmicreticulum membrane]Ig kappa chain V-IIIregion POM [plasmamembrane]BTRC [cytosol]p-Y239,Y240,Y317-SHC1-2[plasma membrane]Ig kappa chain V-Iregion CAR [plasmamembrane]REL [cytosol]Ig kappa chain V-IVregion STH [plasmamembrane]PSMC2 [cytosol]Ig kappa chain V-Iregion Gal [plasmamembrane]Ig heavy chain V-IIregion NEWM [plasmamembrane]KRAS(1-186) [plasmamembrane]Ig kappa chain Vregion EV15 [plasmamembrane]IGKV1-5(23-?)[plasma membrane]ITPR1 [endoplasmicreticulum membrane]Ig kappa chain V-IIIregion CLL [plasmamembrane]Ig heavy chain V-Iregion EU [plasmamembrane]Ig kappa chain V-IVregion B17 [plasmamembrane]Ig lambda chain V-Iregion NEWM [plasmamembrane]Ig lambda chainV-III region LOI[plasma membrane]Ig heavy chain V-Iregion WOL [plasmamembrane]Ig heavy chain V-IIregion NEWM [plasmamembrane]Ig kappa chain V-Iregion Ni [plasmamembrane]Ig heavy chain V-IIIregion NIE [plasmamembrane]Ig lambda chain V-IIregion TRO [plasmamembrane]Ig heavy chain V-IIIregion BUR [plasmamembrane]Ig lambda chain V-IIregion NEI [plasmamembrane]Ig heavy chain V-IIregion OU [plasmamembrane]Ig heavy chain V-IIIregion NIE [plasmamembrane]CARD11(1-1147)[cytosol]p-S19,S23-NFKBIB[cytosol]Ig heavy chain V-IIIregion BUT [plasmamembrane]Ig heavy chain V-IIregion NEWM [plasmamembrane]IGHV(1-?) [plasmamembrane]Ig kappa chain V-Iregion Walker[plasma membrane]STIM1 DimerIg lambda chain V-IIregion WIN [plasmamembrane]PSMA6 [cytosol]Ig kappa chain V-IIIregion HIC [plasmamembrane]Ig heavy chain V-Iregion SIE [plasmamembrane]IGLC6(?-106) [plasmamembrane]Ca2+ [endoplasmicreticulum lumen]IGLC3(?-106) [plasmamembrane]Ig kappa chain V-IIIregion VH [plasmamembrane]Ig kappa chain V-IIIregion SIE [plasmamembrane]Ig lambda chain V-Iregion HA [plasmamembrane]IGLV(23-?) [plasmamembrane]Ig kappa chain V-Iregion Wes [plasmamembrane]Ig heavy chain V-IIIregion TRO [plasmamembrane]IGHV(1-?) [plasmamembrane]IGKV1-5(23-?)[plasma membrane]Ig kappa chain V-Iregion Walker[plasma membrane]RELA [cytosol]Ig kappa chain V-IIIregion B6 [plasmamembrane]Ig heavy chain V-IIIregion GAL [plasmamembrane]Ig lambda chain V-IIregion MGC [plasmamembrane]Ig kappa chain V-Iregion Walker[plasma membrane]Ig kappa chain V-IIIregion GOL [plasmamembrane]Ig heavy chain V-IIIregion TRO [plasmamembrane]Ig kappa chain Vregion EV15 [plasmamembrane]IGKC(1-106) [plasmamembrane]p-Y196,Y207-CD79B[plasma membrane]Ig kappa chain V-Iregion HK101 [plasmamembrane]Ig kappa chain V-Iregion Scw [plasmamembrane]NF-kappaBp50/p65/c-Rel DimerIg kappa chain V-IIIregion NG9 [plasmamembrane]Ig lambda chain V-IIregion BOH [plasmamembrane]Ig heavy chain V-IIIregion WEA [plasmamembrane]Ig lambda chainV-VII region MOT[plasma membrane]p-Y139-DAPP1 [plasmamembrane]Ig lambda chain V-IIregion NIG-84[plasma membrane]Ig kappa chain V-IVregion Len [plasmamembrane]Tacrolimus [cytosol]IGHV7-81(1-?)[plasma membrane]Ig heavy chain V-IIIregion DOB [plasmamembrane]CUL1 [cytosol]Ig kappa chain V-IIIregion HIC [plasmamembrane]Ig heavy chain V-IIregion OU [plasmamembrane]CyclophilinA:Cyclosporin AIg lambda chain V-IVregion Kern [plasmamembrane]Ig heavy chain V-Iregion Mot [plasmamembrane]IGKC(1-106) [plasmamembrane]Ig lambda chain V-IIregion BO [plasmamembrane]PSMD13 [cytosol]Ig heavy chain V-IIIregion TUR [plasmamembrane]Ig lambda chain V-Iregion BL2 [plasmamembrane]STIM1:TRPC1ATPPSMB4 [cytosol]Ig kappa chain V-Iregion BAN [plasmamembrane]Ig heavy chain V-IIIregion POM [plasmamembrane]Ig kappa chain V-IVregion STH [plasmamembrane]ADPIg kappa chain V-IIIregion WOL [plasmamembrane]Ig heavy chain V-IIIregion LAY [plasmamembrane]BLNK (SLP-65)SignalosomeIg heavy chain V-Iregion HG3 [plasmamembrane]NFKBIA [cytosol]Ig heavy chain V-IIIregion TUR [plasmamembrane]Ig lambda chain V-Iregion MEM [plasmamembrane]NFKB1(1-433)[cytosol]Ig kappa chain V-IIIregion B6 [plasmamembrane]SKP1 [cytosol]Ig lambda chain V-VIregion EB4 [plasmamembrane]ADPNCK1 [plasmamembrane]SYK [plasmamembrane]NF-kappaBp50/p65/c-Rel DimerIg heavy chain V-Iregion EU [plasmamembrane]Ig lambda chain V-Iregion WAH [plasmamembrane]Ig kappa chain V-IIIregion Ti [plasmamembrane]Ig kappa chain V-IIIregion IARC/BL41[plasma membrane]IGLC7(?-106) [plasmamembrane]Ig lambda chain V-IIregion VIL [plasmamembrane]Ig kappa chain V-Iregion Rei [plasmamembrane]Ig lambda chain V-Iregion HA [plasmamembrane]CBL [cytosol]Ig kappa chain V-IIregion TEW [plasmamembrane]Ig heavy chain V-IIIregion WAS [plasmamembrane]Ig kappa chain V-Iregion Daudi [plasmamembrane]Ig kappa chain V-Iregion AG [plasmamembrane]Ig kappa chain V-Iregion Scw [plasmamembrane]Ig lambda chain V-IIregion BO [plasmamembrane]Ig lambda chain V-Iregion NIG-64[plasma membrane]PRKCBIg lambda chain Vregion 4A [plasmamembrane]ATPIg heavy chain V-IIIregion WEA [plasmamembrane]IGKVA18(21-?)[plasma membrane]CD19 Signalosomep-4Y-PIK3AP1 [plasmamembrane]Ig lambda chain Vregion 4A [plasmamembrane]IGKV4-1(21-?)[plasma membrane]Ig heavy chain V-IIregion OU [plasmamembrane]Ig heavy chain V-IIregion COR [plasmamembrane]PSMC4 [cytosol]CD79A [plasmamembrane]Ig lambda chain V-IIregion TRO [plasmamembrane]Ig lambda chain V-IVregion X [plasmamembrane]IGLC3(?-106) [plasmamembrane]Activated PKC betaIGLC3(?-106) [plasmamembrane]Ig kappa chain V-Iregion Scw [plasmamembrane]Ig kappa chain V-Iregion Mev [plasmamembrane]Ig kappa chain V-IIIregion WOL [plasmamembrane]Ig kappa chain V-Iregion Lay [plasmamembrane]PSMD11 [cytosol]Ig heavy chain V-IIIregion DOB [plasmamembrane]Ig kappa chain V-IIregion TEW [plasmamembrane]Ig lambda chain V-VIregion WLT [plasmamembrane]Ig lambda chain V-IIregion BUR [plasmamembrane]Ig heavy chain V-IIregion WAH [plasmamembrane]Ig kappa chain V-Iregion EU [plasmamembrane]Ig heavy chain V-IIIregion ZAP [plasmamembrane]PSMF1(2-271)[cytosol]IGLC6(?-106) [plasmamembrane]Ig kappa chain V-IVregion B17 [plasmamembrane]Ig lambda chain V-IIregion MGC [plasmamembrane]Ig lambda chain V-VIregion SUT [plasmamembrane]Ig kappa chain V-Iregion AU [plasmamembrane]IGHM(?-452) [plasmamembrane]Ig heavy chain V-IIregion WAH [plasmamembrane]Ig lambda chainV-VII region MOT[plasma membrane]Ig heavy chain V-Iregion Mot [plasmamembrane]Ig kappa chain V-Iregion BAN [plasmamembrane]p-S559,S644,S652-CARD11(1-1147)[plasma membrane]Ig lambda chain V-IVregion Kern [plasmamembrane]Ig heavy chain V-IIIregion TUR [plasmamembrane]NFKB1(1-433)[cytosol]Ig lambda chain V-IIregion BO [plasmamembrane]Ig kappa chain V-IIIregion HIC [plasmamembrane]Ig kappa chain V-Iregion Rei [plasmamembrane]STIM1:CalciumBCRIg kappa chain V-Iregion AG [plasmamembrane]IKBKB [plasmamembrane]CD79B [plasmamembrane]PSMA4 [cytosol]Ig kappa chain V-Iregion HK101 [plasmamembrane]NCK1Ig heavy chain V-IIregion ARH-77[plasma membrane]Ig lambda chain V-IIregion BUR [plasmamembrane]SH3KBP1 [plasmamembrane]GRB2-1 [plasmamembrane]Ig lambda chain V-Vregion DEL [plasmamembrane]Ig kappa chain V-IIIregion IARC/BL41[plasma membrane]Ig kappa chain V-IIIregion Ti [plasmamembrane]PIP3 activates AKTsignalingIg lambda chain V-VIregion SUT [plasmamembrane]CUL1 [cytosol]Ig heavy chain V-Iregion ND [plasmamembrane]Ig kappa chain V-Iregion Lay [plasmamembrane]Ig lambda chainV-III region SH[plasma membrane]Phosphatidylserine[plasma membrane]Ig lambda chain V-IIregion NIG-58[plasma membrane]GRB2-1 [plasmamembrane]Ig lambda chain V-IIregion TOG [plasmamembrane]Ig kappa chain V-Iregion BAN [plasmamembrane]STIM1 [endoplasmicreticulum membrane]Ig lambda chain V-Iregion NIG-64[plasma membrane]Ig kappa chain V-Iregion DEE [plasmamembrane]REL [cytosol]Ig kappa chain V-IIIregion IARC/BL41[plasma membrane]Ig kappa chain V-IIregion TEW [plasmamembrane]Ig lambda chain V-Iregion BL2 [plasmamembrane]NFKBIE [cytosol]Ig kappa chain V-IIIregion SIE [plasmamembrane]Ig lambda chain V-Iregion BL2 [plasmamembrane]Ig kappa chain V-IIregion FR [plasmamembrane]Ig lambda chain V-IIregion MGC [plasmamembrane]PSMA8 [cytosol]Ig lambda chain V-VIregion EB4 [plasmamembrane]PSMA2 [cytosol]Ig heavy chain V-Iregion HG3 [plasmamembrane]GTP [cytosol]PSMD14 [cytosol]Ig lambda chain V-IIregion NIG-84[plasma membrane]p-Y188,Y199-CD79A[plasma membrane]CD19:VAV1Ig kappa chain V-IIregion TEW [plasmamembrane]Ig lambda chain V-Iregion NEW [plasmamembrane]Ig heavy chain V-IIIregion TEI [plasmamembrane]ADPIg kappa chain V-IIIregion IARC/BL41[plasma membrane]Ig lambda chain V-VIregion AR [plasmamembrane]Ig kappa chain V-IIIregion IARC/BL41[plasma membrane]Ig kappa chain V-Iregion Ni [plasmamembrane]Ca2+ [cytosol]Ig kappa chain V-IIregion FR [plasmamembrane]Ig lambda chainV-III region SH[plasma membrane]IGHM(?-452) [plasmamembrane]IGLC3(?-106) [plasmamembrane]Ig kappa chain V-IVregion Len [plasmamembrane]PIK3CD [plasmamembrane]Ig heavy chain V-IIIregion JON [plasmamembrane]IGHD(?-384) [plasmamembrane]Ig lambda chain V-Iregion EPS [plasmamembrane]Ig heavy chain V-Iregion WOL [plasmamembrane]p-BCL10 [plasmamembrane]Ig heavy chain V-IIIregion LAY [plasmamembrane]Ig heavy chain V-Iregion HG3 [plasmamembrane]Ig kappa chain V-Iregion Roy [plasmamembrane]IGHV7-81(1-?)[plasma membrane]Ig kappa chain V-IIIregion SIE [plasmamembrane]Ig heavy chain V-IIregion SESS [plasmamembrane]SOS1 [cytosol]Ig heavy chain V-Iregion SIE [plasmamembrane]Ig kappa chain V-Iregion Mev [plasmamembrane]Ig lambda chain V-IVregion Bau [plasmamembrane]ADPCBL [plasmamembrane]IGKC(1-106) [plasmamembrane]Ub-21,22-p-S32,S36-NFKBIA[cytosol]Ig heavy chain V-IIIregion BUR [plasmamembrane]ATPIg heavy chain V-IIregion OU [plasmamembrane]Ig lambda chain V-IIregion NIG-58[plasma membrane]IGHV7-81(1-?)[plasma membrane]Ig lambda chain Vregion 4A [plasmamembrane]IGLC2(?-106) [plasmamembrane]Ig lambda chain V-VIregion NIG-48[plasma membrane]MAP3K7Ig kappa chain V-Iregion Wes [plasmamembrane]Ig kappa chain V-IIregion GM607 [plasmamembrane]IGHD(?-384) [plasmamembrane]Ig kappa chain V-IIIregion SIE [plasmamembrane]Ig heavy chain V-IIIregion BUT [plasmamembrane]Ig lambda chain V-Iregion EPS [plasmamembrane]Ig kappa chain V-IIIregion VG [plasmamembrane]CD19 [plasmamembrane]Ig lambda chain V-Iregion VOR [plasmamembrane]Ig kappa chain V-Iregion Hau [plasmamembrane]Ig kappa chain V-Iregion Bi [plasmamembrane]Ig heavy chain V-IIIregion ZAP [plasmamembrane]Ig lambda chainV-VII region MOT[plasma membrane]Ig kappa chain Vregion EV15 [plasmamembrane]Ig lambda chain V-Iregion HA [plasmamembrane]Ig kappa chain V-IIIregion HAH [plasmamembrane]Ig kappa chain V-IIIregion Ti [plasmamembrane]Ig heavy chain V-IIregion COR [plasmamembrane]CBLB [cytosol]Ig heavy chain V-IIregion HE [plasmamembrane]Ig kappa chain V-Iregion Lay [plasmamembrane]Ig heavy chain V-IIIregion KOL [plasmamembrane]Ig heavy chain V-IIIregion WEA [plasmamembrane]IGLC7(?-106) [plasmamembrane]Ig kappa chain V-IIIregion NG9 [plasmamembrane]Ig lambda chain V-Iregion MEM [plasmamembrane]Ig heavy chain V-IIIregion GA [plasmamembrane]Ig kappa chain V-IIregion Cum [plasmamembrane]Ig lambda chain V-IIregion TOG [plasmamembrane]p-Y194,Y195,Y272-SHC1-1(156-583)[plasma membrane]Ig kappa chain V-IIregion Cum [plasmamembrane]IGLC6(?-106) [plasmamembrane]Ig lambda chain V-Iregion BL2 [plasmamembrane]Ig kappa chain V-IVregion JI [plasmamembrane]PLC gamma1/2Ig kappa chain V-IIIregion HAH [plasmamembrane]Ig kappa chain V-Iregion Gal [plasmamembrane]Ig heavy chain V-Iregion SIE [plasmamembrane]Ig kappa chain V-IIregion MIL [plasmamembrane]Ig heavy chain V-Iregion HG3 [plasmamembrane]Ig lambda chain V-Iregion HA [plasmamembrane]Ig lambda chainV-VII region MOT[plasma membrane]p-6Y-SYK [plasmamembrane]Ig heavy chain V-IIIregion BUT [plasmamembrane]Ig kappa chain V-Iregion Walker[plasma membrane]IGLC1(1-105) [plasmamembrane]IGLC2(?-106) [plasmamembrane]Ig lambda chain V-IIregion TRO [plasmamembrane]CARMA1:MALT1:BCL10IGHM(?-452) [plasmamembrane]Ca2+p-S157,S161-Ub-NFKBIE[cytosol]IGHD(?-384) [plasmamembrane]Ig lambda chain V-Iregion BL2 [plasmamembrane]Ig kappa chain V-Iregion AU [plasmamembrane]Ig heavy chain V-IIIregion BUT [plasmamembrane]Ig heavy chain V-IIIregion BRO [plasmamembrane]Ig kappa chain V-Iregion Hau [plasmamembrane]Ig kappa chain V-IIIregion VH [plasmamembrane]Ig lambda chain V-IIregion MGC [plasmamembrane]Ig heavy chain V-IIIregion HIL [plasmamembrane]Ig lambda chain V-IVregion Kern [plasmamembrane]Ig kappa chain V-IIIregion VH [plasmamembrane]Ig kappa chain V-Iregion Kue [plasmamembrane]Ig heavy chain V-IIIregion POM [plasmamembrane]Ig kappa chain V-Iregion Rei [plasmamembrane]NFKB1(1-433)[cytosol]PSMD10 [cytosol]Ig lambda chain V-IIregion BO [plasmamembrane]FBXW11 [cytosol]Ig lambda chain V-IIregion NIG-58[plasma membrane]Ig kappa chain V-Iregion WEA [plasmamembrane]Ig lambda chain V-IIregion VIL [plasmamembrane]Ig lambda chain V-IIregion WIN [plasmamembrane]Ig kappa chain V-IIregion MIL [plasmamembrane]Ig lambda chain V-Iregion WAH [plasmamembrane]Ig lambda chain V-IVregion Hil [plasmamembrane]Ig kappa chain V-Iregion EU [plasmamembrane]Ig lambda chain V-IIregion BO [plasmamembrane]Ig lambda chainV-III region LOI[plasma membrane]PSMD2 [cytosol]Ig heavy chain V-IIIregion BUR [plasmamembrane]Ig lambda chain V-Iregion VOR [plasmamembrane]NF-kappaB:p-IkB:SCF-betaTrCPIGLC3(?-106) [plasmamembrane]Zn2+ [cytosol]Ig heavy chain V-Iregion ND [plasmamembrane]Ig lambda chain V-Iregion NIG-64[plasma membrane]Ig kappa chain V-IIIregion CLL [plasmamembrane]Ig heavy chain V-IIIregion NIE [plasmamembrane]Ig lambda chain V-Iregion NEWM [plasmamembrane]Ig lambda chain V-Vregion DEL [plasmamembrane]Ig kappa chain V-IIIregion NG9 [plasmamembrane]Ig heavy chain V-IIIregion ZAP [plasmamembrane]Ig lambda chain V-IVregion Kern [plasmamembrane]Ig kappa chain V-Iregion AG [plasmamembrane]Ig heavy chain V-IIIregion CAM [plasmamembrane]Ig lambda chain V-Iregion NEWM [plasmamembrane]p-S19,S23-Ub-NFKBIB[cytosol]PIK3CD:PIK3R1Ig kappa chain V-IIIregion HIC [plasmamembrane]Ig heavy chain V-Iregion ND [plasmamembrane]Ig lambda chain V-IIregion MGC [plasmamembrane]Ig kappa chain V-IVregion STH [plasmamembrane]Ig heavy chain V-Iregion HG3 [plasmamembrane]PPP3CB(2-524)[cytosol]Ig lambda chain V-IVregion Bau [plasmamembrane]Ig kappa chain V-Iregion HK101 [plasmamembrane]Ig lambda chain V-IIregion TOG [plasmamembrane]BLNK:GRB2:SOS1:CIN85:CBLIg lambda chain V-Iregion MEM [plasmamembrane]Ig kappa chain V-IIregion GM607 [plasmamembrane]Ig lambda chain V-Iregion EPS [plasmamembrane]Ig lambda chainV-III region LOI[plasma membrane]Ig heavy chain V-IIIregion HIL [plasmamembrane]Ig kappa chain V-Iregion Scw [plasmamembrane]Ig lambda chainV-III region SH[plasma membrane]Ig kappa chain V-Iregion BAN [plasmamembrane]Ig lambda chain V-Iregion NEW [plasmamembrane]Ig kappa chain V-Iregion Walker[plasma membrane]Ig kappa chain V-Iregion BAN [plasmamembrane]Ig heavy chain V-IIIregion BUR [plasmamembrane]Ig lambda chain V-IIregion NIG-84[plasma membrane]Ig lambda chain V-IVregion X [plasmamembrane]Ig heavy chain V-IIregion MCE [plasmamembrane]REL [cytosol]Ig kappa chain V-IIIregion NG9 [plasmamembrane]Ig heavy chain V-Iregion ND [plasmamembrane]PSMD6(2-389)[cytosol]Ig lambda chain V-VIregion AR [plasmamembrane]Ig heavy chain V-IIIregion LAY [plasmamembrane]Ig lambda chain V-IVregion Hil [plasmamembrane]Ig kappa chain V-Iregion Wes [plasmamembrane]Ig lambda chain V-VIregion EB4 [plasmamembrane]IGHM(?-452) [plasmamembrane]HRAS(1-186) [plasmamembrane]Active IKK complexIg kappa chain V-IVregion STH [plasmamembrane]IGLC1(1-105) [plasmamembrane]Ig kappa chain V-IIIregion POM [plasmamembrane]IGHV(1-?) [plasmamembrane]Ig lambda chain V-IIregion BOH [plasmamembrane]Ig heavy chain V-IIregion SESS [plasmamembrane]Ig lambda chain V-Iregion NIG-64[plasma membrane]IGHD(?-384) [plasmamembrane]Ig heavy chain V-IIIregion WEA [plasmamembrane]IGKV1-5(23-?)[plasma membrane]Ig lambda chain V-Vregion DEL [plasmamembrane]ORAI1 [plasmamembrane]Ig heavy chain V-IIregion SESS [plasmamembrane]Ig heavy chain V-Iregion WOL [plasmamembrane]Ig lambda chain V-IIregion BOH [plasmamembrane]Ig lambda chain V-Iregion WAH [plasmamembrane]Ig kappa chain V-IIIregion VH [plasmamembrane]p-Y196,Y207-CD79B[plasma membrane]Ig kappa chain V-Iregion Wes [plasmamembrane]Ig kappa chain V-Iregion Bi [plasmamembrane]IGHV(1-?) [plasmamembrane]Ig heavy chain V-IIregion ARH-77[plasma membrane]Ig kappa chain V-Iregion Roy [plasmamembrane]PI(3,4,5)P3 [plasmamembrane]Ig lambda chain V-IIregion BOH [plasmamembrane]Ig kappa chain V-Iregion Kue [plasmamembrane]Ig heavy chain V-IIIregion TRO [plasmamembrane]Ig kappa chain V-Iregion Roy [plasmamembrane]p-Y188,Y199-CD79A[plasma membrane]Ig kappa chain V-IIregion MIL [plasmamembrane]Ig kappa chain V-IIIregion HIC [plasmamembrane]Ca2+ [plasmamembrane]Ig heavy chain V-Iregion Mot [plasmamembrane]Ig kappa chain V-Iregion Kue [plasmamembrane]Ig kappa chain V-IIIregion NG9 [plasmamembrane]Ig kappa chain V-Iregion Walker[plasma membrane]Ig heavy chain V-IIregion MCE [plasmamembrane]Ig lambda chain V-IVregion Hil [plasmamembrane]IGKVA18(21-?)[plasma membrane]BTRC [cytosol]p-CARMA1 Oligomerp21 RAS:GTPSH3KBP1 [cytosol]Ig kappa chain V-IIregion RPMI 6410[plasma membrane]Ig lambda chainV-VII region MOT[plasma membrane]Ig lambda chain Vregion 4A [plasmamembrane]Ig heavy chain V-IIIregion GAL [plasmamembrane]Ig kappa chain V-Iregion Ka [plasmamembrane]Ig kappa chain V-IIIregion SIE [plasmamembrane]Ig heavy chain V-IIIregion LAY [plasmamembrane]Ig lambda chain V-Iregion WAH [plasmamembrane]Ig kappa chain V-IIregion RPMI 6410[plasma membrane]IGLC6(?-106) [plasmamembrane]Ig lambda chain V-Vregion DEL [plasmamembrane]PSMB9 [cytosol]Ig heavy chain V-IIIregion WEA [plasmamembrane]PSMB6 [cytosol]Ig lambda chain V-IIregion TOG [plasmamembrane]PRKCB [plasmamembrane]Ig heavy chain V-IIIregion POM [plasmamembrane]Ig lambda chain V-IVregion Hil [plasmamembrane]Ig kappa chain V-IVregion B17 [plasmamembrane]PhosphatidylserineCD79B [plasmamembrane]VAV1 [plasmamembrane]GDP [cytosol]Ig heavy chain V-IIIregion POM [plasmamembrane]Ig heavy chain V-Iregion EU [plasmamembrane]Ig lambda chain V-Iregion VOR [plasmamembrane]Ig heavy chain V-IIIregion WAS [plasmamembrane]KRAS(1-186) [plasmamembrane]PSMA3 [cytosol]NFKBIB [cytosol]IGKV4-1(21-?)[plasma membrane]Ig kappa chain V-IIIregion HAH [plasmamembrane]Ig heavy chain V-IIregion MCE [plasmamembrane]Antigen:p-BCR:SYKIg kappa chain V-IIregion FR [plasmamembrane]Ig lambda chain V-IIregion VIL [plasmamembrane]Ig heavy chain V-IIIregion JON [plasmamembrane]Ig kappa chain V-Iregion DEE [plasmamembrane]Ig heavy chain V-IIIregion CAM [plasmamembrane]CBLB [plasmamembrane]IGLC1(1-105) [plasmamembrane]Ig kappa chain V-IVregion STH [plasmamembrane]Ig lambda chain V-IVregion Kern [plasmamembrane]Ig lambda chain V-Iregion VOR [plasmamembrane]Ig heavy chain V-IIIregion TIL [plasmamembrane]PIK3CD [plasmamembrane]Ig kappa chain V-Iregion Mev [plasmamembrane]Ig heavy chain V-IIIregion BUT [plasmamembrane]IGHM(?-452) [plasmamembrane]Ig kappa chain Vregion EV15 [plasmamembrane]Ig kappa chain V-Iregion Daudi [plasmamembrane]Ig lambda chainV-III region LOI[plasma membrane]p-S157,S161-NFKBIE[cytosol]Ig heavy chain V-Iregion ND [plasmamembrane]Ig lambda chain V-IIregion BO [plasmamembrane]Ig heavy chain V-IIIregion WAS [plasmamembrane]p-6Y-SYK [plasmamembrane]Ig kappa chain Vregion EV15 [plasmamembrane]Ig kappa chain V-IIIregion B6 [plasmamembrane]Ig heavy chain V-IIIregion WAS [plasmamembrane]Ig lambda chain V-VIregion EB4 [plasmamembrane]Ig heavy chain V-IIregion HE [plasmamembrane]I(1,4,5)P3Ig kappa chain V-IIIregion IARC/BL41[plasma membrane]Ig kappa chain V-IIIregion VG [plasmamembrane]p-6Y-CD19 [plasmamembrane]PSMC3 [cytosol]ADPIg heavy chain V-IIIregion DOB [plasmamembrane]PI(3,4,5)P3IGKV4-1(21-?)[plasma membrane]Ig heavy chain V-IIIregion HIL [plasmamembrane]Ig heavy chain V-IIIregion CAM [plasmamembrane]Ig heavy chain V-IIIregion GA [plasmamembrane]Ig heavy chain V-IIIregion JON [plasmamembrane]REL [cytosol]p-S19,S23-NFKBIB[cytosol]CD79A [plasmamembrane]Ig heavy chain V-IIregion DAW [plasmamembrane]p21 RAS:GDPIg kappa chain V-IIIregion B6 [plasmamembrane]MALT1 [plasmamembrane]Ig kappa chain V-IIregion FR [plasmamembrane]Ig kappa chain V-Iregion Bi [plasmamembrane]Ig heavy chain V-IIIregion GA [plasmamembrane]IGLC2(?-106) [plasmamembrane]Ig heavy chain V-IIIregion POM [plasmamembrane]Ca2+ [cytosol]Ig kappa chain V-IIregion Cum [plasmamembrane]Ig lambda chain V-IIregion NIG-58[plasma membrane]PSME1 [cytosol]Ig kappa chain V-IIIregion GOL [plasmamembrane]Ig lambda chain Vregion 4A [plasmamembrane]Ig heavy chain V-IIIregion NIE [plasmamembrane]Ig lambda chain V-Iregion HA [plasmamembrane]Ig kappa chain V-Iregion Hau [plasmamembrane]Ig heavy chain V-IIIregion JON [plasmamembrane]PIK3R1 [plasmamembrane]Ig lambda chain V-IIregion BUR [plasmamembrane]Ig heavy chain V-IIIregion TRO [plasmamembrane]Ig kappa chain V-Iregion Gal [plasmamembrane]Ig heavy chain V-IIIregion DOB [plasmamembrane]Ig kappa chain V-Iregion Bi [plasmamembrane]IgH heavy chainV-III region VH26precursor [plasmamembrane]PSMC1(2-440)[cytosol]IP3 receptor:IP3complexIGKV1-5(23-?)[plasma membrane]Ig lambda chain V-IIregion TOG [plasmamembrane]Ig kappa chain V-IIIregion CLL [plasmamembrane]SKP1 [cytosol]Ig kappa chain V-IIIregion VH [plasmamembrane]Ig lambda chain V-Iregion HA [plasmamembrane]ATPIg lambda chain V-Vregion DEL [plasmamembrane]p-12S-NFATC1[cytosol]Ig kappa chain V-Iregion Mev [plasmamembrane]Ig kappa chain V-IIIregion HAH [plasmamembrane]VAV1 [plasmamembrane]Ig lambda chain V-Iregion NIG-64[plasma membrane]Ig kappa chain V-Iregion Bi [plasmamembrane]Ig kappa chain V-Iregion Ni [plasmamembrane]Ig lambda chain V-IVregion X [plasmamembrane]Ig heavy chain V-IIregion OU [plasmamembrane]Ig kappa chain V-Iregion Ni [plasmamembrane]ADPIg lambda chain V-IIregion WIN [plasmamembrane]Ig kappa chain V-IIIregion Ti [plasmamembrane]Ig heavy chain V-IIregion DAW [plasmamembrane]IGHV(1-?) [plasmamembrane]Ig kappa chain V-Iregion Roy [plasmamembrane]Ig heavy chain V-IIIregion POM [plasmamembrane]Ig kappa chain V-IIregion TEW [plasmamembrane]PI(4,5)P2IGHD(?-384) [plasmamembrane]Ig kappa chain V-Iregion Gal [plasmamembrane]Ig kappa chain V-Iregion HK101 [plasmamembrane]Ig heavy chain V-IIIregion LAY [plasmamembrane]p-S32,S36-NFKBIA[cytosol]Ig heavy chain V-IIIregion WAS [plasmamembrane]Ig kappa chain V-IIregion RPMI 6410[plasma membrane]Ig lambda chain V-VIregion SUT [plasmamembrane]Ig kappa chain V-Iregion DEE [plasmamembrane]Ig heavy chain V-IIIregion TUR [plasmamembrane]IGKC(1-106) [plasmamembrane]Ig heavy chain V-Iregion SIE [plasmamembrane]BTKIg kappa chain V-Iregion Daudi [plasmamembrane]CBLB [plasmamembrane]Ig heavy chain V-IIIregion DOB [plasmamembrane]Ig lambda chain V-Iregion EPS [plasmamembrane]Ig heavy chain V-IIIregion WAS [plasmamembrane]Ig heavy chain V-IIIregion BRO [plasmamembrane]Antigen:BCRIg lambda chain V-IIregion TOG [plasmamembrane]IGHV7-81(1-?)[plasma membrane]Ig kappa chain V-IIregion MIL [plasmamembrane]Ig kappa chain V-Iregion Daudi [plasmamembrane]Ig kappa chain V-Iregion AU [plasmamembrane]Ig heavy chain V-IIregion MCE [plasmamembrane]Ig lambda chain V-IVregion Bau [plasmamembrane]Ig kappa chain V-Iregion WEA [plasmamembrane]Ig lambda chain V-Vregion DEL [plasmamembrane]Ig heavy chain V-IIregion COR [plasmamembrane]Ig heavy chain V-IIIregion GAL [plasmamembrane]RELA [cytosol]SOS1 [plasmamembrane]PSMC6(2-389)[cytosol]Ig kappa chain V-Iregion Lay [plasmamembrane]Ig heavy chain V-IIIregion TUR [plasmamembrane]Ig lambda chain V-IVregion MOL [plasmamembrane]Ig kappa chain V-Iregion WAT [plasmamembrane]Ig lambda chain V-IVregion Hil [plasmamembrane]Ig heavy chain V-IIIregion BRO [plasmamembrane]AntigenIg lambda chain V-IIregion NIG-58[plasma membrane]Ig lambda chain V-Iregion NEWM [plasmamembrane]IKKA:IKKB:NEMOp-BCL10 [plasmamembrane]Ig kappa chain V-Iregion HK101 [plasmamembrane]Ig kappa chain V-Iregion CAR [plasmamembrane]RELA [cytosol]Ig heavy chain V-IIregion NEWM [plasmamembrane]p-Y188,Y199-CD79A[plasma membrane]IGLC1(1-105) [plasmamembrane]Ig heavy chain V-Iregion ND [plasmamembrane]Ig kappa chain V-Iregion AU [plasmamembrane]Ig kappa chain V-Iregion HK101 [plasmamembrane]IGKV4-1(21-?)[plasma membrane]Ig lambda chain V-VIregion WLT [plasmamembrane]p-14S-NFATC2[cytosol]Ig heavy chain V-IIIregion GA [plasmamembrane]Ig heavy chain V-IIIregion KOL [plasmamembrane]BLNK [cytosol]Ig heavy chain V-IIregion DAW [plasmamembrane]PPP3CA [cytosol]Ig kappa chain V-IIregion RPMI 6410[plasma membrane]Ig heavy chain V-IIregion DAW [plasmamembrane]Ig kappa chain V-Iregion DEE [plasmamembrane]Ig heavy chain V-IIregion NEWM [plasmamembrane]Ig kappa chain V-Iregion WEA [plasmamembrane]Ig heavy chain V-IIregion COR [plasmamembrane]Ig kappa chain V-Iregion WAT [plasmamembrane]IGKV4-1(21-?)[plasma membrane]Ig heavy chain V-IIIregion ZAP [plasmamembrane]Ig lambda chain V-IVregion MOL [plasmamembrane]Ig lambda chain V-IVregion Bau [plasmamembrane]Ig heavy chain V-IIregion ARH-77[plasma membrane]Ig lambda chain V-VIregion SUT [plasmamembrane]Ig kappa chain V-Iregion EU [plasmamembrane]Ig lambda chain V-IIregion NIG-84[plasma membrane]Ig kappa chain V-Iregion Hau [plasmamembrane]Ig heavy chain V-IIregion SESS [plasmamembrane]Ig kappa chain V-Iregion CAR [plasmamembrane]CBL [plasmamembrane]Ig kappa chain V-Iregion CAR [plasmamembrane]Ig kappa chain V-IIIregion GOL [plasmamembrane]IGLC2(?-106) [plasmamembrane]PSMB7 [cytosol]Ig heavy chain V-IIIregion TIL [plasmamembrane]Ig lambda chain V-Iregion MEM [plasmamembrane]Ig kappa chain V-IIIregion HIC [plasmamembrane]Ig lambda chain V-Iregion NEW [plasmamembrane]IGLC2(?-106) [plasmamembrane]IGLC7(?-106) [plasmamembrane]Ig heavy chain V-IIregion HE [plasmamembrane]Ig kappa chain V-IVregion JI [plasmamembrane]Ig kappa chain V-Iregion Lay [plasmamembrane]Ig lambda chain V-IVregion X [plasmamembrane]Ig heavy chain V-IIIregion GA [plasmamembrane]Ig kappa chain V-Iregion Rei [plasmamembrane]Ig lambda chain V-IIregion NEI [plasmamembrane]Ig lambda chain V-IIregion WIN [plasmamembrane]IGKVA18(21-?)[plasma membrane]PSME4 [cytosol]IgH heavy chainV-III region VH26precursor [plasmamembrane]Ig lambda chain V-Iregion WAH [plasmamembrane]Ig heavy chain V-IIIregion WEA [plasmamembrane]Ig lambda chain V-VIregion NIG-48[plasma membrane]Ig heavy chain V-IIIregion BRO [plasmamembrane]Ig heavy chain V-IIIregion TEI [plasmamembrane]Ig heavy chain V-IIregion ARH-77[plasma membrane]Ig lambda chain V-IIregion TRO [plasmamembrane]RELA [cytosol]Ig lambda chain V-IVregion MOL [plasmamembrane]Ig kappa chain V-IIIregion VH [plasmamembrane]ITPR2 [endoplasmicreticulum membrane]IGLV(23-?) [plasmamembrane]Ig kappa chain Vregion EV15 [plasmamembrane]Ig heavy chain V-IIIregion NIE [plasmamembrane]Ig kappa chain V-Iregion Bi [plasmamembrane]Ig heavy chain V-IIregion MCE [plasmamembrane]Ig lambda chain V-VIregion AR [plasmamembrane]Ig kappa chain V-IIregion Cum [plasmamembrane]p-Y196,Y207-CD79B[plasma membrane]Ig heavy chain V-IIIregion HIL [plasmamembrane]p-Y753,Y759,Y1217-PLCG2[plasma membrane]6089, 1015193186172, 81, 112, 14159, 63, 66, 8459, 66, 76, 84, 136772316, 49, 1277671, 137261591557628, 931634, 36, 100, 12158


Description

Mature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, Fu et al. 1975, Kunkel et al. 1975, Van Noesel et al. 1992, Sanchez et al. 1993, reviewed in Brezski and Monroe 2008). Binding of antigen to the immunoglobulin activates phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the cytoplasmic tails of Ig-alpha and Ig-beta by Src family tyrosine kinases, including LYN, FYN, and BLK (Nel et al. 1984, Yamanashi et al. 1991, Flaswinkel and Reth 1994, Saouaf et al. 1994, Hata et al. 1994, Saouaf et al. 1995, reviewed in Gauld and Cambier 2004, reviewed in Harwood and Batista 2010).
The protein kinase SYK binds the phosphorylated immunoreceptor tyrosine-activated motifs (ITAMs) on the cytoplasmic tails of Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) (Wienands et al. 1995, Rowley et al. 1995, Tsang et al. 2008). The binding causes the activation and autophosphorylation of SYK (Law et al. 1994, Baldock et al. 2000, Irish et al. 2006, Tsang et al. 2008, reviewed in Bradshaw 2010).
Activated SYK and other kinases phosphorylate BLNK (SLP-65), BCAP, and CD19 which serve as scaffolds for the assembly of large complexes, the signalosomes, by recruiting phosphoinositol 3-kinase (PI3K), phospholipase C gamma (predominantly PLC-gamma2 in B cells, Coggeshall et al. 1992), NCK, BAM32, BTK, VAV1, and SHC. The effectors are phosphorylated by SYK and other kinases.
PLC-gamma associated with BLNK hydrolyzes phosphatidylinositol-4,5-bisphosphate to yield inositol-1,4,5-trisphosphate (IP3) and diacylglycerol (Carter et al. 1991, Kim et al. 2004). IP3 binds receptors on the endoplasmic reticulum and causes release of calcium ions from the ER into the cytosol. The depletion of calcium from the ER in turn activates STIM1 to interact with ORAI and TRPC1 channels in the plasma membrane, resulting in an influx of extracellular calcium ions (Muik et al. 2008, Luik et al. 2008, Park et al. 2009, Mori et al. 2002). PI3K associated with BCAP and CD19 phosphorylates phosphatidylinositol 4,5-bisphosphate to yield phosphatidyinositol 3,4,5-trisphosphate.
Second messengers (calcium, diacylglycerol, inositol 1,4,5-trisphosphate, and phosphatidylinositol 3,4,5-trisphosphate) trigger signaling pathways: NF-kappaB is activated via protein kinase C beta, RAS is activated via RasGRP proteins, NF-AT is activated via calcineurin, and AKT (PKB) is activated via PDK1 (reviewed in Shinohara and Kurosaki 2009, Stone 2006).Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=983705

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Bibliography

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  139. Hanasaki K, Powell LD, Varki A.; ''Binding of human plasma sialoglycoproteins by the B cell-specific lectin CD22. Selective recognition of immunoglobulin M and haptoglobin.''; PubMed Europe PMC Scholia
  140. Nisitani S, Kato RM, Rawlings DJ, Witte ON, Wahl MI.; ''In situ detection of activated Bruton's tyrosine kinase in the Ig signaling complex by phosphopeptide-specific monoclonal antibodies.''; PubMed Europe PMC Scholia
  141. Kunkel HG.; ''Surface markers of human lymphocytes.''; PubMed Europe PMC Scholia
  142. Bohnenberger H, Oellerich T, Engelke M, Hsiao HH, Urlaub H, Wienands J.; ''Complex phosphorylation dynamics control the composition of the Syk interactome in B cells.''; PubMed Europe PMC Scholia
  143. Li Z, Nabel GJ.; ''A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription.''; PubMed Europe PMC Scholia
  144. Rodriguez R, Matsuda M, Perisic O, Bravo J, Paul A, Jones NP, Light Y, Swann K, Williams RL, Katan M.; ''Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling.''; PubMed Europe PMC Scholia
  145. Chiu CW, Dalton M, Ishiai M, Kurosaki T, Chan AC.; ''BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins.''; PubMed Europe PMC Scholia
  146. Alland L, Peseckis SM, Atherton RE, Berthiaume L, Resh MD.; ''Dual myristylation and palmitylation of Src family member p59fyn affects subcellular localization.''; PubMed Europe PMC Scholia
  147. Smith KG, Tarlinton DM, Doody GM, Hibbs ML, Fearon DT.; ''Inhibition of the B cell by CD22: a requirement for Lyn.''; PubMed Europe PMC Scholia
  148. Sanchez M, Misulovin Z, Burkhardt AL, Mahajan S, Costa T, Franke R, Bolen JB, Nussenzweig M.; ''Signal transduction by immunoglobulin is mediated through Ig alpha and Ig beta.''; PubMed Europe PMC Scholia
  149. Wu C, Ghosh S.; ''beta-TrCP mediates the signal-induced ubiquitination of IkappaBbeta.''; PubMed Europe PMC Scholia
  150. Okamura H, Aramburu J, García-Rodríguez C, Viola JP, Raghavan A, Tahiliani M, Zhang X, Qin J, Hogan PG, Rao A.; ''Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity.''; PubMed Europe PMC Scholia
  151. Lin L, Czerwinski R, Kelleher K, Siegel MM, Wu P, Kriz R, Aulabaugh A, Stahl M.; ''Activation loop phosphorylation modulates Bruton's tyrosine kinase (Btk) kinase domain activity.''; PubMed Europe PMC Scholia
  152. Nel AE, Landreth GE, Goldschmidt-Clermont PJ, Tung HE, Galbraith RM.; ''Enhanced tyrosine phosphorylation in B lymphocytes upon complexing of membrane immunoglobulin.''; PubMed Europe PMC Scholia
  153. Padeh S, Levitzki A, Gazit A, Mills GB, Roifman CM.; ''Activation of phospholipase C in human B cells is dependent on tyrosine phosphorylation.''; PubMed Europe PMC Scholia
  154. Roose JP, Mollenauer M, Ho M, Kurosaki T, Weiss A.; ''Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes.''; PubMed Europe PMC Scholia
  155. Han S, Collins BE, Bengtson P, Paulson JC.; ''Homomultimeric complexes of CD22 in B cells revealed by protein-glycan cross-linking.''; PubMed Europe PMC Scholia
  156. Salim K, Bottomley MJ, Querfurth E, Zvelebil MJ, Gout I, Scaife R, Margolis RL, Gigg R, Smith CI, Driscoll PC, Waterfield MD, Panayotou G.; ''Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase.''; PubMed Europe PMC Scholia
  157. Wienands J, Schweikert J, Wollscheid B, Jumaa H, Nielsen PJ, Reth M.; ''SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation.''; PubMed Europe PMC Scholia
  158. Brezski RJ, Monroe JG.; ''B-cell receptor.''; PubMed Europe PMC Scholia
  159. Luik RM, Wang B, Prakriya M, Wu MM, Lewis RS.; ''Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation.''; PubMed Europe PMC Scholia
  160. Leitges M, Schmedt C, Guinamard R, Davoust J, Schaal S, Stabel S, Tarakhovsky A.; ''Immunodeficiency in protein kinase cbeta-deficient mice.''; PubMed Europe PMC Scholia
  161. Burke JR, Wood MK, Ryseck RP, Walther S, Meyers CA.; ''Peptides corresponding to the N and C termini of IkappaB-alpha, -beta, and -epsilon as probes of the two catalytic subunits of IkappaB kinase, IKK-1 and IKK-2.''; PubMed Europe PMC Scholia
  162. Vasile S, Coligan JE, Yoshida M, Seon BK.; ''Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex.''; PubMed Europe PMC Scholia
  163. Wienands J, Hombach J, Radbruch A, Riesterer C, Reth M.; ''Molecular components of the B cell antigen receptor complex of class IgD differ partly from those of IgM.''; PubMed Europe PMC Scholia
  164. Fu C, Chan AC.; ''Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activation.''; PubMed Europe PMC Scholia
  165. Roose JP, Mollenauer M, Gupta VA, Stone J, Weiss A.; ''A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells.''; PubMed Europe PMC Scholia
  166. Blank V, Kourilsky P, Israël A.; ''Cytoplasmic retention, DNA binding and processing of the NF-kappa B p50 precursor are controlled by a small region in its C-terminus.''; PubMed Europe PMC Scholia
  167. McConnell FM, Shears SB, Lane PJ, Scheibel MS, Clark EA.; ''Relationships between the degree of cross-linking of surface immunoglobulin and the associated inositol 1,4,5-trisphosphate and Ca2+ signals in human B cells.''; PubMed Europe PMC Scholia
  168. Wei SJ, Williams JG, Dang H, Darden TA, Betz BL, Humble MM, Chang FM, Trempus CS, Johnson K, Cannon RE, Tennant RW.; ''Identification of a specific motif of the DSS1 protein required for proteasome interaction and p53 protein degradation.''; PubMed Europe PMC Scholia
  169. Brooks SR, Li X, Volanakis EJ, Carter RH.; ''Systematic analysis of the role of CD19 cytoplasmic tyrosines in enhancement of activation in Daudi human B cells: clustering of phospholipase C and Vav and of Grb2 and Sos with different CD19 tyrosines.''; PubMed Europe PMC Scholia
  170. Su TT, Guo B, Kawakami Y, Sommer K, Chae K, Humphries LA, Kato RM, Kang S, Patrone L, Wall R, Teitell M, Leitges M, Kawakami T, Rawlings DJ.; ''PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling.''; PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
112687view16:08, 9 October 2020ReactomeTeamReactome version 73
101604view11:47, 1 November 2018ReactomeTeamreactome version 66
101140view21:32, 31 October 2018ReactomeTeamreactome version 65
100668view20:06, 31 October 2018ReactomeTeamreactome version 64
100218view16:51, 31 October 2018ReactomeTeamreactome version 63
99769view15:17, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
93934view13:46, 16 August 2017ReactomeTeamreactome version 61
93521view11:25, 9 August 2017ReactomeTeamreactome version 61
87188view08:07, 19 July 2016EgonwOntology Term : 'signaling pathway' added !
86619view09:22, 11 July 2016ReactomeTeamreactome version 56
83158view10:13, 18 November 2015ReactomeTeamVersion54
81511view13:03, 21 August 2015ReactomeTeamVersion53
76984view08:27, 17 July 2014ReactomeTeamFixed remaining interactions
76689view12:05, 16 July 2014ReactomeTeamFixed remaining interactions
76015view10:07, 11 June 2014ReactomeTeamRe-fixing comment source
75724view11:19, 10 June 2014ReactomeTeamReactome 48 Update
75074view14:02, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74860view17:46, 2 May 2014EgonwMarked two metabolites as a DataNode type="Metabolite"...
74721view08:48, 30 April 2014ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
26S proteasomeComplexREACT_2353 (Reactome)
ADPMetaboliteCHEBI:16761 (ChEBI)
ATPMetaboliteCHEBI:15422 (ChEBI)
Activated PKC betaComplexREACT_4856 (Reactome)
Active CalmodulinComplexREACT_3178 (Reactome)
Active IKK complexComplexREACT_119869 (Reactome)
Antigen:BCRComplexREACT_119368 (Reactome)
Antigen:p-BCR:SYKComplexREACT_120132 (Reactome)
Antigen:p-BCR:p-SYK:p-BLNKComplexREACT_120231 (Reactome)
Antigen:p-BCR:p-SYKComplexREACT_120006 (Reactome)
Antigen:p-BCRComplexREACT_119697 (Reactome)
AntigenREACT_119525 (Reactome)
BCAP SignalosomeComplexREACT_119322 (Reactome)
BCRComplexREACT_119956 (Reactome)
BLK(2-505)ProteinP51451 (Uniprot-TrEMBL)
BLNK (SLP-65) SignalosomeComplexREACT_120226 (Reactome)
BLNK [cytosol]ProteinQ8WV28 (Uniprot-TrEMBL)
BLNK:GRB2:SOS1:CIN85:CBLComplexREACT_120158 (Reactome)
BTKProteinQ06187 (Uniprot-TrEMBL)
BTRC [cytosol]ProteinQ9Y297 (Uniprot-TrEMBL)
CALM1 [cytosol]ProteinP62158 (Uniprot-TrEMBL)
CALM1ProteinP62158 (Uniprot-TrEMBL)
CARD11(1-1147) [cytosol]ProteinQ9BXL7 (Uniprot-TrEMBL)
CARMA1 oligomerComplexREACT_119167 (Reactome)
CARMA1:BCL10:MALT1:TAK1:IKKComplexREACT_118993 (Reactome) TAK1 and the IKK complex are observed to migrate to lipid rafts containing phosphorylated CARMA1, BCL10, and MALT1. By analogy with NF-kappaB signaling pathways in other cells, the CARMA1:BCL10MALT1:TAK1:IKK complex in B cells may also contain TAB1, TAB2 and/or TAB3, TRAF6.
CARMA1:BCL10:MALT1:TAK1ComplexREACT_119896 (Reactome) TAK1 and the IKK complex are observed to migrate to lipid rafts containing phosphorylated CARMA1, BCL10, and MALT1. By analogy with NF-kappaB signaling pathways in other cells, the CARMA1:BCL10MALT1:TAK1:IKK complex in B cells may also contain TAB1, TAB2 and/or TAB3, TRAF6.
CARMA1:MALT1:BCL10ComplexREACT_119308 (Reactome)
CBL [cytosol]ProteinP22681 (Uniprot-TrEMBL)
CBL [plasma membrane]ProteinP22681 (Uniprot-TrEMBL)
CBLB [cytosol]ProteinQ13191 (Uniprot-TrEMBL)
CBLB [plasma membrane]ProteinQ13191 (Uniprot-TrEMBL)
CD19 SignalosomeComplexREACT_119603 (Reactome)
CD19 [plasma membrane]ProteinP15391 (Uniprot-TrEMBL)
CD19:VAV1ComplexREACT_119973 (Reactome)
CD79A [plasma membrane]ProteinP11912 (Uniprot-TrEMBL)
CD79B [plasma membrane]ProteinP40259 (Uniprot-TrEMBL)
CHUK [cytosol]ProteinO15111 (Uniprot-TrEMBL)
CHUK [plasma membrane]ProteinO15111 (Uniprot-TrEMBL)
CRAC channelComplexREACT_24443 (Reactome)
CUL1 [cytosol]ProteinQ13616 (Uniprot-TrEMBL)
Ca2+ [cytosol]MetaboliteCHEBI:29108 (ChEBI)
Ca2+ [endoplasmic reticulum lumen]MetaboliteCHEBI:29108 (ChEBI)
Ca2+ [plasma membrane]MetaboliteCHEBI:29108 (ChEBI)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
Calcineurin (CaN)ComplexREACT_119672 (Reactome)
Calcineurin:Phosphorylated NFATC1/2/3ComplexREACT_119836 (Reactome)
Cyclophilin A:Cyclosporin AComplexREACT_119713 (Reactome)
Cyclosporin A [cytosol]MetaboliteCHEBI:4031 (ChEBI)
DAG [plasma membrane]MetaboliteCHEBI:17815 (ChEBI)
DAGCHEBI:17815 (ChEBI)
DAPP1ProteinQ9UN19 (Uniprot-TrEMBL)
Dephosphorylated NFATC1/2/3ProteinREACT_119501 (Reactome)
FBXW11 [cytosol]ProteinQ9UKB1 (Uniprot-TrEMBL)
FKBP1A [cytosol]ProteinP62942 (Uniprot-TrEMBL)
FKBP1A:TacrolimusComplexREACT_120070 (Reactome)
FYN(2-537)ProteinP06241 (Uniprot-TrEMBL)
Fe3+ [cytosol]MetaboliteCHEBI:29034 (ChEBI)
GDP [cytosol]MetaboliteCHEBI:17552 (ChEBI)
GRB2-1 [cytosol]ProteinP62993-1 (Uniprot-TrEMBL)
GRB2-1 [plasma membrane]ProteinP62993-1 (Uniprot-TrEMBL)
GRB2-1ProteinP62993-1 (Uniprot-TrEMBL)
GTP [cytosol]MetaboliteCHEBI:15996 (ChEBI)
HRAS(1-186) [plasma membrane]ProteinP01112 (Uniprot-TrEMBL)
I(1,4,5)P3 [cytosol]MetaboliteCHEBI:16595 (ChEBI)
I(1,4,5)P3MetaboliteCHEBI:16595 (ChEBI)
IGHD(?-384) [plasma membrane]ProteinP01880 (Uniprot-TrEMBL)
IGHM(?-452) [plasma membrane]ProteinP01871 (Uniprot-TrEMBL)
IGHV(1-?) [plasma membrane]ProteinA2KUC3 (Uniprot-TrEMBL)
IGHV7-81(1-?) [plasma membrane]ProteinQ6PIL0 (Uniprot-TrEMBL)
IGKC(1-106) [plasma membrane]ProteinP01834 (Uniprot-TrEMBL)
IGKV1-5(23-?) [plasma membrane]ProteinP01602 (Uniprot-TrEMBL)
IGKV4-1(21-?) [plasma membrane]ProteinP06312 (Uniprot-TrEMBL)
IGKVA18(21-?) [plasma membrane]ProteinA2NJV5 (Uniprot-TrEMBL)
IGLC1(1-105) [plasma membrane]ProteinP0CG04 (Uniprot-TrEMBL)
IGLC2(?-106) [plasma membrane]ProteinP0CG05 (Uniprot-TrEMBL)
IGLC3(?-106) [plasma membrane]ProteinP0CG06 (Uniprot-TrEMBL)
IGLC6(?-106) [plasma membrane]ProteinP0CF74 (Uniprot-TrEMBL)
IGLC7(?-106) [plasma membrane]ProteinA0M8Q6 (Uniprot-TrEMBL)
IGLV(23-?) [plasma membrane]ProteinA2NXD2 (Uniprot-TrEMBL)
IKBKB [cytosol]ProteinO14920 (Uniprot-TrEMBL)
IKBKB [plasma membrane]ProteinO14920 (Uniprot-TrEMBL)
IKBKG [cytosol]ProteinQ9Y6K9 (Uniprot-TrEMBL)
IKBKG [plasma membrane]ProteinQ9Y6K9 (Uniprot-TrEMBL)
IKKA:IKKB:NEMOComplexREACT_7693 (Reactome)
IP3 receptor homotetramerComplexREACT_12247 (Reactome)
IP3 receptor:IP3 complexComplexREACT_12249 (Reactome)
ITPR1 [endoplasmic reticulum membrane]ProteinQ14643 (Uniprot-TrEMBL)
ITPR2 [endoplasmic reticulum membrane]ProteinQ14571 (Uniprot-TrEMBL)
ITPR3 [endoplasmic reticulum membrane]ProteinQ14573 (Uniprot-TrEMBL)
Ig heavy chain V-I

region EU [plasma

membrane]		ProteinP01742 (Uniprot-TrEMBL)
Ig heavy chain V-I

region HG3 [plasma

membrane]		ProteinP01743 (Uniprot-TrEMBL)
Ig heavy chain V-I

region Mot [plasma

membrane]		ProteinP06326 (Uniprot-TrEMBL)
Ig heavy chain V-I

region ND [plasma

membrane]		ProteinP01744 (Uniprot-TrEMBL)
Ig heavy chain V-I

region SIE [plasma

membrane]		ProteinP01761 (Uniprot-TrEMBL)
Ig heavy chain V-I

region WOL [plasma

membrane]		ProteinP01760 (Uniprot-TrEMBL)
Ig heavy chain V-II

region ARH-77

[plasma membrane]		ProteinP06331 (Uniprot-TrEMBL)
Ig heavy chain V-II

region COR [plasma

membrane]		ProteinP01815 (Uniprot-TrEMBL)
Ig heavy chain V-II

region DAW [plasma

membrane]		ProteinP01816 (Uniprot-TrEMBL)
Ig heavy chain V-II

region HE [plasma

membrane]		ProteinP01818 (Uniprot-TrEMBL)
Ig heavy chain V-II

region MCE [plasma

membrane]		ProteinP01817 (Uniprot-TrEMBL)
Ig heavy chain V-II

region NEWM [plasma

membrane]		ProteinP01825 (Uniprot-TrEMBL)
Ig heavy chain V-II

region OU [plasma

membrane]		ProteinP01814 (Uniprot-TrEMBL)
Ig heavy chain V-II

region SESS [plasma

membrane]		ProteinP04438 (Uniprot-TrEMBL)
Ig heavy chain V-II

region WAH [plasma

membrane]		ProteinP01824 (Uniprot-TrEMBL)
Ig heavy chain V-III

region BRO [plasma

membrane]		ProteinP01766 (Uniprot-TrEMBL)
Ig heavy chain V-III

region BUR [plasma

membrane]		ProteinP01773 (Uniprot-TrEMBL)
Ig heavy chain V-III

region BUT [plasma

membrane]		ProteinP01767 (Uniprot-TrEMBL)
Ig heavy chain V-III

region CAM [plasma

membrane]		ProteinP01768 (Uniprot-TrEMBL)
Ig heavy chain V-III

region DOB [plasma

membrane]		ProteinP01782 (Uniprot-TrEMBL)
Ig heavy chain V-III

region GA [plasma

membrane]		ProteinP01769 (Uniprot-TrEMBL)
Ig heavy chain V-III

region GAL [plasma

membrane]		ProteinP01781 (Uniprot-TrEMBL)
Ig heavy chain V-III

region HIL [plasma

membrane]		ProteinP01771 (Uniprot-TrEMBL)
Ig heavy chain V-III

region JON [plasma

membrane]		ProteinP01780 (Uniprot-TrEMBL)
Ig heavy chain V-III

region KOL [plasma

membrane]		ProteinP01772 (Uniprot-TrEMBL)
Ig heavy chain V-III

region LAY [plasma

membrane]		ProteinP01775 (Uniprot-TrEMBL)
Ig heavy chain V-III

region NIE [plasma

membrane]		ProteinP01770 (Uniprot-TrEMBL)
Ig heavy chain V-III

region POM [plasma

membrane]		ProteinP01774 (Uniprot-TrEMBL)
Ig heavy chain V-III

region TEI [plasma

membrane]		ProteinP01777 (Uniprot-TrEMBL)
Ig heavy chain V-III

region TIL [plasma

membrane]		ProteinP01765 (Uniprot-TrEMBL)
Ig heavy chain V-III

region TRO [plasma

membrane]		ProteinP01762 (Uniprot-TrEMBL)
Ig heavy chain V-III

region TUR [plasma

membrane]		ProteinP01779 (Uniprot-TrEMBL)
Ig heavy chain V-III

region WAS [plasma

membrane]		ProteinP01776 (Uniprot-TrEMBL)
Ig heavy chain V-III

region WEA [plasma

membrane]		ProteinP01763 (Uniprot-TrEMBL)
Ig heavy chain V-III

region ZAP [plasma

membrane]		ProteinP01778 (Uniprot-TrEMBL)
Ig kappa chain V

region EV15 [plasma

membrane]		ProteinP06315 (Uniprot-TrEMBL)
Ig kappa chain V-I

region AG [plasma

membrane]		ProteinP01593 (Uniprot-TrEMBL)
Ig kappa chain V-I

region AU [plasma

membrane]		ProteinP01594 (Uniprot-TrEMBL)
Ig kappa chain V-I

region BAN [plasma

membrane]		ProteinP04430 (Uniprot-TrEMBL)
Ig kappa chain V-I

region Bi [plasma

membrane]		ProteinP01595 (Uniprot-TrEMBL)
Ig kappa chain V-I

region CAR [plasma

membrane]		ProteinP01596 (Uniprot-TrEMBL)
Ig kappa chain V-I

region DEE [plasma

membrane]		ProteinP01597 (Uniprot-TrEMBL)
Ig kappa chain V-I

region Daudi [plasma

membrane]		ProteinP04432 (Uniprot-TrEMBL)
Ig kappa chain V-I

region EU [plasma

membrane]		ProteinP01598 (Uniprot-TrEMBL)
Ig kappa chain V-I

region Gal [plasma

membrane]		ProteinP01599 (Uniprot-TrEMBL)
Ig kappa chain V-I

region HK101 [plasma

membrane]		ProteinP01601 (Uniprot-TrEMBL)
Ig kappa chain V-I

region Hau [plasma

membrane]		ProteinP01600 (Uniprot-TrEMBL)
Ig kappa chain V-I

region Ka [plasma

membrane]		ProteinP01603 (Uniprot-TrEMBL)
Ig kappa chain V-I

region Kue [plasma

membrane]		ProteinP01604 (Uniprot-TrEMBL)
Ig kappa chain V-I

region Lay [plasma

membrane]		ProteinP01605 (Uniprot-TrEMBL)
Ig kappa chain V-I

region Mev [plasma

membrane]		ProteinP01612 (Uniprot-TrEMBL)
Ig kappa chain V-I

region Ni [plasma

membrane]		ProteinP01613 (Uniprot-TrEMBL)
Ig kappa chain V-I

region OU [plasma

membrane]		ProteinP01606 (Uniprot-TrEMBL)
Ig kappa chain V-I

region Rei [plasma

membrane]		ProteinP01607 (Uniprot-TrEMBL)
Ig kappa chain V-I

region Roy [plasma

membrane]		ProteinP01608 (Uniprot-TrEMBL)
Ig kappa chain V-I

region Scw [plasma

membrane]		ProteinP01609 (Uniprot-TrEMBL)
Ig kappa chain V-I

region WAT [plasma

membrane]		ProteinP80362 (Uniprot-TrEMBL)
Ig kappa chain V-I

region WEA [plasma

membrane]		ProteinP01610 (Uniprot-TrEMBL)
Ig kappa chain V-I

region Walker

[plasma membrane]		ProteinP04431 (Uniprot-TrEMBL)
Ig kappa chain V-I

region Wes [plasma

membrane]		ProteinP01611 (Uniprot-TrEMBL)
Ig kappa chain V-II

region Cum [plasma

membrane]		ProteinP01614 (Uniprot-TrEMBL)
Ig kappa chain V-II

region FR [plasma

membrane]		ProteinP01615 (Uniprot-TrEMBL)
Ig kappa chain V-II

region GM607 [plasma

membrane]		ProteinP06309 (Uniprot-TrEMBL)
Ig kappa chain V-II

region MIL [plasma

membrane]		ProteinP01616 (Uniprot-TrEMBL)
Ig kappa chain V-II

region RPMI 6410

[plasma membrane]		ProteinP06310 (Uniprot-TrEMBL)
Ig kappa chain V-II

region TEW [plasma

membrane]		ProteinP01617 (Uniprot-TrEMBL)
Ig kappa chain V-III

region B6 [plasma

membrane]		ProteinP01619 (Uniprot-TrEMBL)
Ig kappa chain V-III

region CLL [plasma

membrane]		ProteinP04207 (Uniprot-TrEMBL)
Ig kappa chain V-III

region GOL [plasma

membrane]		ProteinP04206 (Uniprot-TrEMBL)
Ig kappa chain V-III

region HAH [plasma

membrane]		ProteinP18135 (Uniprot-TrEMBL)
Ig kappa chain V-III

region HIC [plasma

membrane]		ProteinP18136 (Uniprot-TrEMBL)
Ig kappa chain V-III

region IARC/BL41

[plasma membrane]		ProteinP06311 (Uniprot-TrEMBL)
Ig kappa chain V-III

region NG9 [plasma

membrane]		ProteinP01621 (Uniprot-TrEMBL)
Ig kappa chain V-III

region POM [plasma

membrane]		ProteinP01624 (Uniprot-TrEMBL)
Ig kappa chain V-III

region SIE [plasma

membrane]		ProteinP01620 (Uniprot-TrEMBL)
Ig kappa chain V-III

region Ti [plasma

membrane]		ProteinP01622 (Uniprot-TrEMBL)
Ig kappa chain V-III

region VG [plasma

membrane]		ProteinP04433 (Uniprot-TrEMBL)
Ig kappa chain V-III

region VH [plasma

membrane]		ProteinP04434 (Uniprot-TrEMBL)
Ig kappa chain V-III

region WOL [plasma

membrane]		ProteinP01623 (Uniprot-TrEMBL)
Ig kappa chain V-IV

region B17 [plasma

membrane]		ProteinP06314 (Uniprot-TrEMBL)
Ig kappa chain V-IV

region JI [plasma

membrane]		ProteinP06313 (Uniprot-TrEMBL)
Ig kappa chain V-IV

region Len [plasma

membrane]		ProteinP01625 (Uniprot-TrEMBL)
Ig kappa chain V-IV

region STH [plasma

membrane]		ProteinP83593 (Uniprot-TrEMBL)
Ig lambda chain

V-III region LOI

[plasma membrane]		ProteinP80748 (Uniprot-TrEMBL)
Ig lambda chain

V-III region SH

[plasma membrane]		ProteinP01714 (Uniprot-TrEMBL)
Ig lambda chain

V-VII region MOT

[plasma membrane]		ProteinP01720 (Uniprot-TrEMBL)
Ig lambda chain V

region 4A [plasma

membrane]		ProteinP04211 (Uniprot-TrEMBL)
Ig lambda chain V-I

region BL2 [plasma

membrane]		ProteinP06316 (Uniprot-TrEMBL)
Ig lambda chain V-I

region EPS [plasma

membrane]		ProteinP06888 (Uniprot-TrEMBL)
Ig lambda chain V-I

region HA [plasma

membrane]		ProteinP01700 (Uniprot-TrEMBL)
Ig lambda chain V-I

region MEM [plasma

membrane]		ProteinP06887 (Uniprot-TrEMBL)
Ig lambda chain V-I

region NEW [plasma

membrane]		ProteinP01701 (Uniprot-TrEMBL)
Ig lambda chain V-I

region NEWM [plasma

membrane]		ProteinP01703 (Uniprot-TrEMBL)
Ig lambda chain V-I

region NIG-64

[plasma membrane]		ProteinP01702 (Uniprot-TrEMBL)
Ig lambda chain V-I

region VOR [plasma

membrane]		ProteinP01699 (Uniprot-TrEMBL)
Ig lambda chain V-I

region WAH [plasma

membrane]		ProteinP04208 (Uniprot-TrEMBL)
Ig lambda chain V-II

region BO [plasma

membrane]		ProteinP01710 (Uniprot-TrEMBL)
Ig lambda chain V-II

region BOH [plasma

membrane]		ProteinP01706 (Uniprot-TrEMBL)
Ig lambda chain V-II

region BUR [plasma

membrane]		ProteinP01708 (Uniprot-TrEMBL)
Ig lambda chain V-II

region MGC [plasma

membrane]		ProteinP01709 (Uniprot-TrEMBL)
Ig lambda chain V-II

region NEI [plasma

membrane]		ProteinP01705 (Uniprot-TrEMBL)
Ig lambda chain V-II

region NIG-58

[plasma membrane]		ProteinP01713 (Uniprot-TrEMBL)
Ig lambda chain V-II

region NIG-84

[plasma membrane]		ProteinP04209 (Uniprot-TrEMBL)
Ig lambda chain V-II

region TOG [plasma

membrane]		ProteinP01704 (Uniprot-TrEMBL)
Ig lambda chain V-II

region TRO [plasma

membrane]		ProteinP01707 (Uniprot-TrEMBL)
Ig lambda chain V-II

region VIL [plasma

membrane]		ProteinP01711 (Uniprot-TrEMBL)
Ig lambda chain V-II

region WIN [plasma

membrane]		ProteinP01712 (Uniprot-TrEMBL)
Ig lambda chain V-IV

region Bau [plasma

membrane]		ProteinP01715 (Uniprot-TrEMBL)
Ig lambda chain V-IV

region Hil [plasma

membrane]		ProteinP01717 (Uniprot-TrEMBL)
Ig lambda chain V-IV

region Kern [plasma

membrane]		ProteinP01718 (Uniprot-TrEMBL)
Ig lambda chain V-IV

region MOL [plasma

membrane]		ProteinP06889 (Uniprot-TrEMBL)
Ig lambda chain V-IV

region X [plasma

membrane]		ProteinP01716 (Uniprot-TrEMBL)
Ig lambda chain V-V

region DEL [plasma

membrane]		ProteinP01719 (Uniprot-TrEMBL)
Ig lambda chain V-VI

region AR [plasma

membrane]		ProteinP01721 (Uniprot-TrEMBL)
Ig lambda chain V-VI

region EB4 [plasma

membrane]		ProteinP06319 (Uniprot-TrEMBL)
Ig lambda chain V-VI

region NIG-48

[plasma membrane]		ProteinP01722 (Uniprot-TrEMBL)
Ig lambda chain V-VI

region SUT [plasma

membrane]		ProteinP06317 (Uniprot-TrEMBL)
Ig lambda chain V-VI

region WLT [plasma

membrane]		ProteinP06318 (Uniprot-TrEMBL)
IgH heavy chain

V-III region VH26 precursor [plasma

membrane]		ProteinP01764 (Uniprot-TrEMBL)
KRAS(1-186) [plasma membrane]ProteinP01116 (Uniprot-TrEMBL)
LYN(2-512)ProteinP07948 (Uniprot-TrEMBL)
MALT1 [plasma membrane]ProteinQ9UDY8 (Uniprot-TrEMBL)
MALT1ProteinQ9UDY8 (Uniprot-TrEMBL)
MAP3K7ProteinO43318 (Uniprot-TrEMBL)
NCK1 [plasma membrane]ProteinP16333 (Uniprot-TrEMBL)
NCK1ProteinP16333 (Uniprot-TrEMBL)
NF-kappa-B p50,/p65,/c-Rel:IKBComplexREACT_119154 (Reactome)
NF-kappa-B p50/ p65/c-Rel:p-IKBComplexREACT_119527 (Reactome)
NF-kappaB p50/p65/c-Rel DimerComplexREACT_118873 (Reactome)
NF-kappaB p50/p65/c-Rel DimerComplexREACT_119326 (Reactome)
NF-kappaB p50/p65/c-Rel:ub-p-IKBComplexREACT_120175 (Reactome)
NF-kappaB:p-IkB:SCF-betaTrCPComplexREACT_119791 (Reactome)
NFKB1(1-433) [cytosol]ProteinP19838 (Uniprot-TrEMBL)
NFKB1(1-433) [nucleoplasm]ProteinP19838 (Uniprot-TrEMBL)
NFKBIA [cytosol]ProteinP25963 (Uniprot-TrEMBL)
NFKBIB [cytosol]ProteinQ15653 (Uniprot-TrEMBL)
NFKBIE [cytosol]ProteinO00221 (Uniprot-TrEMBL)
NRAS [plasma membrane]ProteinP01111 (Uniprot-TrEMBL)
ORAI1 [plasma membrane]ProteinQ96D31 (Uniprot-TrEMBL)
Orai1 dimerComplexREACT_24301 (Reactome)
PI(3,4,5)P3 [plasma membrane]MetaboliteCHEBI:16618 (ChEBI)
PI(3,4,5)P3MetaboliteCHEBI:16618 (ChEBI)
PI(4,5)P2MetaboliteCHEBI:18348 (ChEBI)
PIK3AP1ProteinQ6ZUJ8 (Uniprot-TrEMBL)
PIK3CD [cytosol]ProteinO00329 (Uniprot-TrEMBL)
PIK3CD [plasma membrane]ProteinO00329 (Uniprot-TrEMBL)
PIK3CD:PIK3R1ComplexREACT_119117 (Reactome)
PIK3CD:PIK3R1ComplexREACT_119537 (Reactome)
PIK3R1 [cytosol]ProteinP27986 (Uniprot-TrEMBL)
PIK3R1 [plasma membrane]ProteinP27986 (Uniprot-TrEMBL)
PIP3 activates AKT signalingPathwayWP2653 (WikiPathways) Signaling by AKT is one of the key outcomes of receptor tyrosine kinase (RTK) activation. AKT is activated by the cellular second messenger PIP3, a phospholipid that is generated by PI3K. In ustimulated cells, PI3K class IA enzymes reside in the cytosol as inactive heterodimers composed of p85 regulatory subunit and p110 catalytic subunit. In this complex, p85 stabilizes p110 while inhibiting its catalytic activity. Upon binding of extracellular ligands to RTKs, receptors dimerize and undergo autophosphorylation. The regulatory subunit of PI3K, p85, is recruited to phosphorylated cytosolic RTK domains either directly or indirectly, through adaptor proteins, leading to a conformational change in the PI3K IA heterodimer that relieves inhibition of the p110 catalytic subunit. Activated PI3K IA phosphorylates PIP2, converting it to PIP3; this reaction is negatively regulated by PTEN phosphatase. PIP3 recruits AKT to the plasma membrane, allowing TORC2 to phosphorylate a conserved serine residue of AKT. Phosphorylation of this serine induces a conformation change in AKT, exposing a conserved threonine residue that is then phosphorylated by PDPK1 (PDK1). Phosphorylation of both the threonine and the serine residue is required to fully activate AKT. The active AKT then dissociates from PIP3 and phosphorylates a number of cytosolic and nuclear proteins that play important roles in cell survival and metabolism. For a recent review of AKT signaling, please refer to Manning and Cantley, 2007.
PLC gamma1/2ProteinREACT_120292 (Reactome)
PPIA [cytosol]ProteinP62937 (Uniprot-TrEMBL)
PPP3CA [cytosol]ProteinQ08209 (Uniprot-TrEMBL)
PPP3CB(2-524) [cytosol]ProteinP16298 (Uniprot-TrEMBL)
PPP3R1 [cytosol]ProteinP63098 (Uniprot-TrEMBL)
PRKCB [plasma membrane]ProteinP05771 (Uniprot-TrEMBL)
PRKCBProteinP05771 (Uniprot-TrEMBL)
PSMA1 [cytosol]ProteinP25786 (Uniprot-TrEMBL)
PSMA2 [cytosol]ProteinP25787 (Uniprot-TrEMBL)
PSMA3 [cytosol]ProteinP25788 (Uniprot-TrEMBL)
PSMA4 [cytosol]ProteinP25789 (Uniprot-TrEMBL)
PSMA5 [cytosol]ProteinP28066 (Uniprot-TrEMBL)
PSMA6 [cytosol]ProteinP60900 (Uniprot-TrEMBL)
PSMA7(2-248) [cytosol]ProteinO14818 (Uniprot-TrEMBL)
PSMA8 [cytosol]ProteinQ8TAA3 (Uniprot-TrEMBL)
PSMB1 [cytosol]ProteinP20618 (Uniprot-TrEMBL)
PSMB10 [cytosol]ProteinP40306 (Uniprot-TrEMBL)
PSMB11 [cytosol]ProteinA5LHX3 (Uniprot-TrEMBL)
PSMB2 [cytosol]ProteinP49721 (Uniprot-TrEMBL)
PSMB3 [cytosol]ProteinP49720 (Uniprot-TrEMBL)
PSMB4 [cytosol]ProteinP28070 (Uniprot-TrEMBL)
PSMB5 [cytosol]ProteinP28074 (Uniprot-TrEMBL)
PSMB6 [cytosol]ProteinP28072 (Uniprot-TrEMBL)
PSMB7 [cytosol]ProteinQ99436 (Uniprot-TrEMBL)
PSMB8 [cytosol]ProteinP28062 (Uniprot-TrEMBL)
PSMB9 [cytosol]ProteinP28065 (Uniprot-TrEMBL)
PSMC1(2-440) [cytosol]ProteinP62191 (Uniprot-TrEMBL)
PSMC2 [cytosol]ProteinP35998 (Uniprot-TrEMBL)
PSMC3 [cytosol]ProteinP17980 (Uniprot-TrEMBL)
PSMC4 [cytosol]ProteinP43686 (Uniprot-TrEMBL)
PSMC5 [cytosol]ProteinP62195 (Uniprot-TrEMBL)
PSMC6(2-389) [cytosol]ProteinP62333 (Uniprot-TrEMBL)
PSMD1 [cytosol]ProteinQ99460 (Uniprot-TrEMBL)
PSMD10 [cytosol]ProteinO75832 (Uniprot-TrEMBL)
PSMD11 [cytosol]ProteinO00231 (Uniprot-TrEMBL)
PSMD12 [cytosol]ProteinO00232 (Uniprot-TrEMBL)
PSMD13 [cytosol]ProteinQ9UNM6 (Uniprot-TrEMBL)
PSMD14 [cytosol]ProteinO00487 (Uniprot-TrEMBL)
PSMD2 [cytosol]ProteinQ13200 (Uniprot-TrEMBL)
PSMD3 [cytosol]ProteinO43242 (Uniprot-TrEMBL)
PSMD4(2-377) [cytosol]ProteinP55036 (Uniprot-TrEMBL)
PSMD5 [cytosol]ProteinQ16401 (Uniprot-TrEMBL)
PSMD6(2-389) [cytosol]ProteinQ15008 (Uniprot-TrEMBL)
PSMD7(2-324) [cytosol]ProteinP51665 (Uniprot-TrEMBL)
PSMD8 [cytosol]ProteinP48556 (Uniprot-TrEMBL)
PSMD9 [cytosol]ProteinO00233 (Uniprot-TrEMBL)
PSME1 [cytosol]ProteinQ06323 (Uniprot-TrEMBL)
PSME2 [cytosol]ProteinQ9UL46 (Uniprot-TrEMBL)
PSME3 [cytosol]ProteinP61289 (Uniprot-TrEMBL)
PSME4 [cytosol]ProteinQ14997 (Uniprot-TrEMBL)
PSMF1(2-271) [cytosol]ProteinQ92530 (Uniprot-TrEMBL)
Phosphatidylserine [plasma membrane]MetaboliteCHEBI:18303 (ChEBI)
PhosphatidylserineCHEBI:18303 (ChEBI)
Phosphorylated NFATC1/2/3ProteinREACT_120227 (Reactome)
REL [cytosol]ProteinQ04864 (Uniprot-TrEMBL)
REL [nucleoplasm]ProteinQ04864 (Uniprot-TrEMBL)
RELA [cytosol]ProteinQ04206 (Uniprot-TrEMBL)
RELA [nucleoplasm]ProteinQ04206 (Uniprot-TrEMBL)
RasGRP1/3ProteinREACT_119242 (Reactome)
SCF-beta-TrCp1/2ComplexREACT_119753 (Reactome)
SH3KBP1 [cytosol]ProteinQ96B97 (Uniprot-TrEMBL)
SH3KBP1 [plasma membrane]ProteinQ96B97 (Uniprot-TrEMBL)
SHC1 p46/p52ProteinREACT_111758 (Reactome) SHC1 isoforms p46 and p52 are found in B cells (Smit et al. 1994).
SKP1 [cytosol]ProteinP63208 (Uniprot-TrEMBL)
SOS1 [cytosol]ProteinQ07889 (Uniprot-TrEMBL)
SOS1 [plasma membrane]ProteinQ07889 (Uniprot-TrEMBL)
STIM1 DimerComplexREACT_27372 (Reactome)
STIM1 [endoplasmic reticulum membrane]ProteinQ13586 (Uniprot-TrEMBL)
STIM1:CalciumComplexREACT_119430 (Reactome)
STIM1:TRPC1ComplexREACT_119530 (Reactome)
SYK [plasma membrane]ProteinP43405 (Uniprot-TrEMBL)
SYKProteinP43405 (Uniprot-TrEMBL)
TRPC1 [plasma membrane]ProteinP48995 (Uniprot-TrEMBL)
TRPC1ProteinP48995 (Uniprot-TrEMBL)
Tacrolimus [cytosol]MetaboliteCHEBI:61049 (ChEBI)
Ub-21,22-p-S32,S36-NFKBIA [cytosol]ProteinP25963 (Uniprot-TrEMBL)
UbProteinREACT_3316 (Reactome)
VAV1 [plasma membrane]ProteinP15498 (Uniprot-TrEMBL)
VAV1ProteinP15498 (Uniprot-TrEMBL)
Zn2+ [cytosol]MetaboliteCHEBI:29105 (ChEBI)
p-12S-NFATC1 [cytosol]ProteinO95644 (Uniprot-TrEMBL)
p-13S-NFATC3 [cytosol]ProteinQ12968 (Uniprot-TrEMBL)
p-14S-NFATC2 [cytosol]ProteinQ13469 (Uniprot-TrEMBL)
p-4Y-PIK3AP1 [plasma membrane]ProteinQ6ZUJ8 (Uniprot-TrEMBL)
p-5Y-BLNK [plasma membrane]ProteinQ8WV28 (Uniprot-TrEMBL)
p-6Y-CD19 [plasma membrane]ProteinP15391 (Uniprot-TrEMBL)
p-6Y-SYK [plasma membrane]ProteinP43405 (Uniprot-TrEMBL)
p-BCL10 [plasma membrane]ProteinO95999 (Uniprot-TrEMBL)
p-BCL10ProteinO95999 (Uniprot-TrEMBL)
p-CARMA1 OligomerComplexREACT_119302 (Reactome) The coiled coil (CC) domain of CARMA1 interacts with the CC domain on other CARMA1 molecules to form oligomers of unknown stoichiometry.
p-RasGRP1,3:DAGComplexREACT_118884 (Reactome) RasGRP3 binds diacylglycerol via its C1 domain.
p-S157,S161-NFKBIE [cytosol]ProteinO00221 (Uniprot-TrEMBL)
p-S157,S161-Ub-NFKBIE [cytosol]ProteinO00221 (Uniprot-TrEMBL)
p-S177,S181-IKBKB [cytosol]ProteinO14920 (Uniprot-TrEMBL)
p-S19,S23-NFKBIB [cytosol]ProteinQ15653 (Uniprot-TrEMBL)
p-S19,S23-Ub-NFKBIB [cytosol]ProteinQ15653 (Uniprot-TrEMBL)
p-S32,S36-NFKBIA [cytosol]ProteinP25963 (Uniprot-TrEMBL)
p-S559,S644,S652-CARD11(1-1147) [plasma membrane]ProteinQ9BXL7 (Uniprot-TrEMBL)
p-T133-RASGRP3 [plasma membrane]ProteinQ8IV61 (Uniprot-TrEMBL)
p-T184-RASGRP1 [plasma membrane]ProteinO95267 (Uniprot-TrEMBL)
p-T187-MAP3K7 [plasma membrane]ProteinO43318 (Uniprot-TrEMBL)
p-Y139-DAPP1 [plasma membrane]ProteinQ9UN19 (Uniprot-TrEMBL)
p-Y188,Y199-CD79A [plasma membrane]ProteinP11912 (Uniprot-TrEMBL)
p-Y194,Y195,Y272-SHC1-1(156-583) [plasma membrane]ProteinP29353-3 (Uniprot-TrEMBL)
p-Y196,Y207-CD79B [plasma membrane]ProteinP40259 (Uniprot-TrEMBL) By homology with CD79A (Ig-alpha), CD79B (Ig-beta) is presumed to be phosphorylated on tyrosines 196 and 207.
p-Y223,Y551-BTK [plasma membrane]ProteinQ06187 (Uniprot-TrEMBL)
p-Y239,Y240,Y317-SHC1-2 [plasma membrane]ProteinP29353-2 (Uniprot-TrEMBL)
p-Y753,Y759,Y1217-PLCG2 [plasma membrane]ProteinP16885 (Uniprot-TrEMBL)
p-Y771,Y783-PLCG1 [plasma membrane]ProteinP19174 (Uniprot-TrEMBL)
p21 RAS:GDPComplexREACT_2657 (Reactome)
p21 RAS:GTPComplexREACT_4782 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
26S proteasomemim-catalysisREACT_118617 (Reactome)
ADPArrowREACT_118598 (Reactome)
ADPArrowREACT_118618 (Reactome)
ADPArrowREACT_118689 (Reactome)
ADPArrowREACT_118716 (Reactome)
ADPArrowREACT_118728 (Reactome)
ADPArrowREACT_118733 (Reactome)
ADPArrowREACT_118834 (Reactome)
ATPREACT_118598 (Reactome)
ATPREACT_118618 (Reactome)
ATPREACT_118689 (Reactome)
ATPREACT_118716 (Reactome)
ATPREACT_118728 (Reactome)
ATPREACT_118733 (Reactome)
ATPREACT_118834 (Reactome)
Activated PKC betaArrowREACT_118748 (Reactome)
Activated PKC betamim-catalysisREACT_118598 (Reactome)
Active CalmodulinArrowREACT_12602 (Reactome)
Active CalmodulinREACT_118703 (Reactome)
Active IKK complexArrowREACT_118689 (Reactome)
Active IKK complexmim-catalysisREACT_118618 (Reactome)
Antigen:BCRArrowREACT_118606 (Reactome)
Antigen:BCRREACT_118716 (Reactome)
Antigen:p-BCR:SYKArrowREACT_118749 (Reactome)
Antigen:p-BCR:SYKREACT_118728 (Reactome)
Antigen:p-BCR:p-SYK:p-BLNKArrowREACT_118834 (Reactome)
Antigen:p-BCR:p-SYK:p-BLNKREACT_118566 (Reactome)
Antigen:p-BCR:p-SYK:p-BLNKmim-catalysisREACT_118566 (Reactome)
Antigen:p-BCR:p-SYKArrowREACT_118728 (Reactome)
Antigen:p-BCR:p-SYKREACT_118834 (Reactome)
Antigen:p-BCR:p-SYKmim-catalysisREACT_118728 (Reactome)
Antigen:p-BCR:p-SYKmim-catalysisREACT_118834 (Reactome)
Antigen:p-BCRArrowREACT_118716 (Reactome)
Antigen:p-BCRREACT_118749 (Reactome)
AntigenREACT_118606 (Reactome)
BCAP SignalosomeArrowREACT_118566 (Reactome)
BCAP Signalosomemim-catalysisREACT_118601 (Reactome)
BCRREACT_118606 (Reactome)
BLK(2-505)mim-catalysisREACT_118716 (Reactome)
BLNK (SLP-65) SignalosomeArrowREACT_118566 (Reactome)
BLNK (SLP-65) Signalosomemim-catalysisREACT_118781 (Reactome)
BLNK:GRB2:SOS1:CIN85:CBLREACT_118834 (Reactome)
BTKREACT_118566 (Reactome)
BTKmim-catalysisREACT_118566 (Reactome)
CALM1REACT_12602 (Reactome)
CARMA1 oligomerREACT_118598 (Reactome)
CARMA1:BCL10:MALT1:TAK1:IKKArrowREACT_118585 (Reactome)
CARMA1:BCL10:MALT1:TAK1:IKKREACT_118689 (Reactome)
CARMA1:BCL10:MALT1:TAK1:IKKmim-catalysisREACT_118689 (Reactome)
CARMA1:BCL10:MALT1:TAK1ArrowREACT_118689 (Reactome)
CARMA1:MALT1:BCL10ArrowREACT_118777 (Reactome)
CARMA1:MALT1:BCL10REACT_118585 (Reactome)
CD19 SignalosomeArrowREACT_118566 (Reactome)
CD19 Signalosomemim-catalysisREACT_118828 (Reactome)
CD19:VAV1REACT_118566 (Reactome)
CRAC channelArrowREACT_23904 (Reactome)
CRAC channelmim-catalysisREACT_23967 (Reactome)
Ca2+ArrowREACT_118688 (Reactome)
Ca2+ArrowREACT_118808 (Reactome)
Ca2+ArrowREACT_12074 (Reactome)
Ca2+ArrowREACT_23967 (Reactome)
Ca2+REACT_118688 (Reactome)
Ca2+REACT_118703 (Reactome)
Ca2+REACT_118748 (Reactome)
Ca2+REACT_12074 (Reactome)
Ca2+REACT_12602 (Reactome)
Ca2+REACT_23967 (Reactome)
Calcineurin (CaN)REACT_118703 (Reactome)
Calcineurin:Phosphorylated NFATC1/2/3ArrowREACT_118703 (Reactome)
Calcineurin:Phosphorylated NFATC1/2/3REACT_118664 (Reactome)
Calcineurin:Phosphorylated NFATC1/2/3mim-catalysisREACT_118664 (Reactome)
Cyclophilin A:Cyclosporin ATBarREACT_118664 (Reactome)
DAGArrowREACT_118781 (Reactome)
DAGREACT_118733 (Reactome)
DAGREACT_118748 (Reactome)
DAPP1REACT_118566 (Reactome)
Dephosphorylated NFATC1/2/3ArrowREACT_118664 (Reactome)
FKBP1A:TacrolimusTBarREACT_118664 (Reactome)
FYN(2-537)mim-catalysisREACT_118716 (Reactome)
GRB2-1REACT_118566 (Reactome)
I(1,4,5)P3ArrowREACT_118781 (Reactome)
I(1,4,5)P3ArrowREACT_12074 (Reactome)
I(1,4,5)P3REACT_12008 (Reactome)
IKKA:IKKB:NEMOREACT_118585 (Reactome)
IP3 receptor homotetramerREACT_12008 (Reactome)
IP3 receptor:IP3 complexArrowREACT_12008 (Reactome)
IP3 receptor:IP3 complexmim-catalysisREACT_118808 (Reactome)
IP3 receptor:IP3 complexmim-catalysisREACT_12074 (Reactome)
LYN(2-512)mim-catalysisREACT_118716 (Reactome)
MALT1REACT_118777 (Reactome)
MAP3K7REACT_118585 (Reactome)
NCK1REACT_118566 (Reactome)
NF-kappa-B p50,/p65,/c-Rel:IKBREACT_118618 (Reactome)
NF-kappa-B p50/ p65/c-Rel:p-IKBArrowREACT_118618 (Reactome)
NF-kappa-B p50/ p65/c-Rel:p-IKBREACT_118856 (Reactome)
NF-kappaB p50/p65/c-Rel DimerArrowREACT_118617 (Reactome)
NF-kappaB p50/p65/c-Rel DimerArrowREACT_118705 (Reactome)
NF-kappaB p50/p65/c-Rel DimerREACT_118705 (Reactome)
NF-kappaB p50/p65/c-Rel:ub-p-IKBArrowREACT_118619 (Reactome)
NF-kappaB p50/p65/c-Rel:ub-p-IKBREACT_118617 (Reactome)
NF-kappaB:p-IkB:SCF-betaTrCPArrowREACT_118856 (Reactome)
NF-kappaB:p-IkB:SCF-betaTrCPREACT_118619 (Reactome)
Orai1 dimerREACT_23904 (Reactome)
PI(3,4,5)P3ArrowREACT_118601 (Reactome)
PI(3,4,5)P3ArrowREACT_118828 (Reactome)
PI(4,5)P2REACT_118566 (Reactome)
PI(4,5)P2REACT_118601 (Reactome)
PI(4,5)P2REACT_118781 (Reactome)
PI(4,5)P2REACT_118828 (Reactome)
PIK3AP1REACT_118566 (Reactome)
PIK3CD:PIK3R1REACT_118566 (Reactome)
PIK3CD:PIK3R1mim-catalysisREACT_118566 (Reactome)
PLC gamma1/2REACT_118566 (Reactome)
PRKCBREACT_118748 (Reactome)
PhosphatidylserineREACT_118748 (Reactome)
Phosphorylated NFATC1/2/3REACT_118703 (Reactome)
REACT_118566 (Reactome) Phosphorylated SYK phosphorylates BLNK (SLP-65, Fu et al. 1998, Chiu et al. 2002) and BCAP (inferred from mouse, Okada et al. 2000). Effector molecules are then recruited: phosphoinositol 3-kinase (PI3K), Phospholipase C gamma (predominantly PLC-gamma2 in B cells, Coggeshall et al. 1992), NCK, BAM32, BTK, VAV1, and SHC. The effectors are phosphorylated by SYK and other kinases.
As inferred from chicken DT40 cells and mouse B cells (Okada et al. 2000), phosphorylated BCAP recruits PI3K, which is phosphorylated by a SYK-dependent mechanism (Kuwahara et al. 1996) and produces phosphatidylinositol-3,4,5-trisphosphate (PIP3). PIP3 recruits BAM32 (Marshall et al. 2000) and BTK (de Weers et al. 1994, Baba et al. 2001) via their PH domains. PIP3 also recruits and activates PLC-gamma1 and PLC-gamma2 (Bae et al. 1998). BTK binds phosphorylated BLNK via its SH2 domain (Baba et al. 2001). BTK phosphorylates Phospholipase C gamma-2 (Rodriguez et al. 2001), which activates phospholipase activity (Carter et al. 1991, Roifman and Wang 1992, Kim et al. 2004, Sekiya et al. 2004).
Phosphorylated BLNK recruits PLC gamma, VAV, GRB2, and NCK (Fu and Chan 1997, Fu et al. 1998, Chiu et al. 2002).
SYK phosphorylates SHC which then binds GRB2 (Saxton et al. 1994, Harmer and DeFranco 1997).
CD19 in a stable complex with VAV1 is phosphorylated by Src kinases (inferred from mouse, Xu et al. 2002) and possibly by LYN (inferred from mouse, Fujimoto et al. 2000) in response to BCR activation. Phosphorylated CD19 then binds PI3K (Roifman and Ke 1993, Chalupny et al. 1993, Uckun et al. 1993, Weng et al. 1994, Brooks et al. 2000, Brooks et al. 2004) and can bind PLC-gamma2, which competes with VAV1 for the same binding site on CD19 (Brooks et al. 2000, Brooks et al. 2004).
REACT_118585 (Reactome) TAK1 and the IKK complex are observed to migrate from the cytosol to lipid rafts containing the CARMA1:BCL10:MALT1 (CBM) complex (Sommer et al. 2005, Shinohara et al. 2005 using chicken cells). By analogy with activation of NF-KappaB signaling in T cells, TAK1 in B cells may also be bound to TAB1 and TAB2 or TAB3, which bind K63-conjugated polyubiquitin on a TRAF protein bound to the CBM complex (reviewed in Shinohara et al. 2009).
REACT_118598 (Reactome) CARMA1 is phosphorylated at serines 559, 644, and 652 by Protein Kinase C beta (PKC-beta) (Sommer et al. 2005). CARMA1 is constitutively oligomerized (Tanner et al. 2007) and most CARMA1 in unstimulated cells is cytosolic (Sommer et al. 2005, Tanner et al. 2007), though a portion is constitutively associated with the plasma membrane (Gaide et al. 2002, Sommer et al. 2005). After phosphorylation, CARMA1 is associated with lipid rafts in the plasma membrane (Sommer et al. 2005). Note that some publications refer to CARMA1 with a different N-terminal methionine that is 7 amino acids shorter. In this case the phosphorylated serines are 552, 537, and 645.
REACT_118601 (Reactome) PI3K generates phosphoinositol-3,4,5-trisphosphate (PIP3) from PIP2 after activation of the BCR (Gold et al. 1992, Chantry et al. 1997). Experiments in mice indicate that PI3K associated with BCAP is partly responsible for the activity (Aiba et al. 2008). (PI3K associated with CD19 is also partly responsible (Aiba et al. 2008).)
REACT_118606 (Reactome) Mature, unstimulated B cells express IgM and IgD immunoglobulins on their surfaces (Fu et al. 1974, Fu et al. 1975, reviewed in Kunkel 1975). The immunoglobulins form B cell receptor (BCR) complexes with disulfide-linked heterodimers of Ig-alpha (CD79A) and Ig-beta (CD79B), which have cytoplasmic tails containing immunoreceptor tyrosine-based activation motifs (ITAMs) (van Noesel et al. 1992, Saouaf et al. 1995, inferred from mouse Hombach et al. 1990, Wienands et al. 1990). Upon binding of antigen to the immunoglobulin a chain of phosphorylation events is triggered (Nel et al. 1984, Saouaf et al. 1994, Hata et al. 1994, Saouaf et al. 1995, reviewed in Harwood and Batista 2010).
REACT_118617 (Reactome) Phosphorylated, ubiquitinated IkB is degraded by the proteasome (Miyamoto et al. 1994, Traenckner et al. 1994, Alkalay et al. 1995, DiDonato et al. 1995, Li et al. 1995, Lin et al. 1995, Scherer et al. 1995, Chen et al. 1995). IkB does not dissociate from NF-kB before it is proteolyzed (Miyamoto et al. 1994, Traenckner et al. 1994, DiDonato et al. 1995, Lin et al. 1995).
REACT_118618 (Reactome) Activated IKK complex phosphorylates the I-kappaB component of the cytoplasmic NF-kappaB complex (Zandi et al. 1998, Burke et al. 1999, Heilker et al. 1999). B cells contain I-kappaB-alpha, I-kappaB-beta, and I-kappaB-epsilon (Whiteside et al. 1997, Li and Nabel 1997).
REACT_118619 (Reactome) SKP:Cul:F-box (SCF) complexes containing F-box factors Beta-TrCP1 (BTRCP, E3RSIkappaB) or beta-TrCP2 (BTRCP2, FBXW11, HOS) catalyze the polyubiquitination of IkappaB (Yaron et al. 1998, Fuchs et al. 1999, Suzuki et al. 1999, Tan et al. 1999, Winston et al. 1999, Wu and Ghosh 1999).
REACT_118664 (Reactome) As inferred from mouse (Okamura et al. 2000), calcineurin dephosphorylates NFATC2 at 13 serine residues (Batiuk et al. 1997, Kim et al. 2000). B lymphocytes also contain NFATC2 and NFATC3 which are inferred to undergo dephosphorylation at homologous serines. Dephosphorylation of NFATs exposes a nuclear localization signal which cause NFATs to be imported into the nucleus (Kim et al. 2000). In mouse, Calcineurin is observed to also transit into the nucleus in a complex with NFATs and may remain associated (Shibasaki et al. 1996).
REACT_118688 (Reactome) TRPC1 forms a channel that transports Ca2+ across the plasma membrane. TRPC1 is gated by STIM1 (Ong et al. 2007).
REACT_118689 (Reactome) TAK1 phosphorylates IKK-beta (Wang et al. 2001). As inferred from chicken B cells, the reaction in human B cells may occur when TAK1 and the IKK complex are associated with the CARMA1:BCL10:MALT1 (CBM) complex. During T cell activation TAK1 forms a complex with TAB1 and TAB2, which binds K-63 conjugated polyubiquitin attached to TRAF6 associated with the CBM complex (Sun et al. 2004, reviewed in Shinohara et al. 2009). TRAF6 also polyubiquitinates IKK-gamma in T cells (Zhou et al. 2004). B cells contain functional TRAF6 and TRAF2 (Zhang et al. 2010) so the same mechanism may occur during activation of B cells.
REACT_118703 (Reactome) Calcium activates calcineurin in two ways: binding the regulatory subunit of calcineurin directly and binding calmodulin which then interacts with the catalytic subunit of calcineurin. As inferred from mouse, B lymphocytes contain the R1 regulatory subunit (PPP3R1) and the beta catalytic subunit (PPP3CB).
In the presence of calcium and calcium:calmodulin calcineurin binds phosphorylated and unphosphorylated NFATs at 2 regions in the N-terminus (Luo et al. 1996, Garcia-Cozar et al. 1998, Park et al. 2000, evidence from mouse in Loh et al. 1996 and Wesselborg et al. 1996). Calcineurin also weakly interacts with NFATs in the absence of calcium (Garcia-Cozar et al. 1998).
REACT_118705 (Reactome) Nf-kappaB subunits contain nuclear localization sequences and, in the absence of IkB, are translocated to the nucleus (Bauerle and Baltimore 1988, Blank et al. 1991, Ghosh et al. 2008, Fagerlund et al. 2008). c-Rel binds to importins alpha5, alpha6, and alpha7; RelB binds to importins alpha5 and alpha6; p52 binds importin alpha3, alpha4, alpha5, and alpha6 (Fagerlund et al. 2008)
REACT_118716 (Reactome) The B cell receptor (BCR) comprises an immunoglobulin complexed with a heterodimer of Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29). After immunoglobulin IgM or IgD binds antigen the associated Ig-alpha and Ig-beta are each observed to be phosphorylated at two tyrosine residues in the cytoplasmic immunoreceptor tyrosine-activated motif (ITAM) (Sanchez et al. 1993, Hata et al. 1994, Saouaf et al. 1994, Saouaf et al. 1995). Saouaf et al. (1995) showed that the kinase Blk could phosphorylate both tyrosines of each ITAM and that the kinase SYK specifically bound phosphorylated but not unphosphorylated ITAMs. In mouse the kinase Lyn and other kinases phosphorylate one tyrosine and Syk is believed to phosphorylate the other (Yamanashi et al. 1991, Flaswinkel and Reth 1994, Rolli et al. 2002).
REACT_118728 (Reactome) The SYK protein tyrosine kinase autophosphorylates at tyrosines 131, 323, 348, 352, 525, and 526 (Law et al. 1994, Rowley et al. 1995, Baldock et al. 2000, Irish et al. 2006, Papp et al. 2007, Chen et al. 2008, Tsang et al. 2008). The autophosphorylation increases the kinase activity of SYK. SYK is also phosporylated on additional residues in response to BCR activation (Bohnenberger et al. 2011).
REACT_118733 (Reactome) RasGRP1 and RasGRP3 translocate to the plasma membrane where they bind diacylglycerol (Lorenzo et al. 2001) and are phosphorylated (Teixeira et al. 2003, Zheng et al. 2005). Though RasGRP3 is phosphorylated in vitro and in some cell lines (e.g. Ramos cells) by protein kinase C theta (PKC-theta, Zheng et al. 2005), normal B cells do not contain PKC-theta (Meller et al. 1999). Both Rasgrp1 and Rasgrp3 participate in activating Ras in response to BCR signaling in mouse B cells (Coughlin et al. 2005).
REACT_118748 (Reactome) Human Protein kinase C beta (PKC-beta) is activated by calcium ions, diacylglycerol, and binds phosphatidylserine (Kochs et al. 1991). Experiments in mice have shown that knocking out PKC-beta causes severe defects in B cells, leading to the conclusion that PKC-beta is the predominant signaling PKC in these cells (Leitges et al. 1996, Su et al. 2002, Saijo et al. 2002).
REACT_118749 (Reactome) The SYK protein tyrosine kinase binds specifically to phosphorylated immunoreceptor tyrosine-activated motifs (ITAMs) on Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) (Law et al. 1994, Saouaf et al. 1995, Rowley et al. 1995, Tsang et al. 2008). The binding activates the kinase activity of SYK (Rowley et al. 1995, Tsang et al. 2008).
REACT_118759 (Reactome) The polybasic region of STIM1 interacts with 2 aspartate residues in the C-terminal region of TRPC1 (Zeng et al. 2008, Huang et al. 2006). The STIM1:TRPC1 complex can form a tenary complex with ORAI1 (Ong et al. 2007, Jardin et al. 2008) and ORAI participates in function of STIM1:TRPC1 channels (Cheng et al. 2008, Cheng et al. 2011). As inferred from chicken DT40 cells, TRPC1 (and possibly other TRP channels) participates in store-operated calcium influx during signaling by the B cell receptor (Mori et al. 2002).
REACT_118777 (Reactome) CARMA1 is phosphorylated and recruits BCL10 and MALT1 to the plasma membrane to form the CBM complex (Sommer et al. 2005, Tanner et al. 2007). Evidence from T cells (Jurkat cells) indicates that MALT1 and BCL10 oligomerize to activate the IKK complex (Zhou 2004).
REACT_118781 (Reactome) Phospholipase C gamma (PLC-gamma) is activated by phosphorylation in response to antigen-binding by the B cell receptor (Carter et al. 1991, Roitman and Wang 1992, Rodriguez et al. 2001, Kim et al. 2004, Sekiya et al. 2004). Phospholipase C gamma hydrolyzes phosphatidylinositol-4,5-bisphosphate to yield inositol-1,4,5-trisphosphate and diacylglycerol (Carter et al. 1991, Kim et al. 2004). Human B cells contain both PLC-gamma1 and PLC-gamma2, with PLC-gamma2 predominating (Coggeshall et al. 1992).
REACT_118807 (Reactome) RasGRP1 (Roose et al. 2007) and RasGRP3 (Ohba et al. 2000, Yamashita et al. 2000, Rebhun et al. 2000, Lorenzo et al. 2001) catalyze the exchange of GDP for GTP bound by RAS.
REACT_118808 (Reactome) In the resting state the luminal domain of STIM1 binds Ca2+ ions within the endoplasmic reticulum and this binding prevents dimerization of STIM1 (Luik et al. 2008). Upon depletion of Ca2+ ions from the endoplasmic reticulum, STIM1 is no longer bound to Ca2+ and forms homodimers (Muik et al. 2008, Luik et al. 2008, Park et al. 2009).
REACT_118828 (Reactome) PI3K generates phosphoinositol-3,4,5-trisphosphate (PIP3) from PIP2 after activation of the BCR (Gold et al. 1992). Experiments in mice indicate that PI3K associated with CD19 is partly responsible for the activity (Buhl et al. 1997, Otero et al. 2001, Aiba et al. 2008). (PI3K associated with BCAP is also partly responsible (Aiba et al. 2008).)
REACT_118834 (Reactome) BLNK (SLP-65, BASH) forms a stable complex with GRB2, SOS1, and CIN85 in the cytosol. The complex is recruited to the plasma membrane where activated (phosphorylated) SYK phosphorylates BLNK at tyrosines 72, 84, 96, 178, and 189 (Fu et al. 1998, Chiu et al. 2002, inferred from mouse in Wienands et al. 1998, from chicken in Oellerich et al. 2009). Phosphorylated BLNK serves as a scaffold that binds effector molecules such as Phospholipase C. As inferred from mouse, BLNK interacts with phosphorylated tyrosines on CD79A (Ig-alpha) (Engels et al. 2001, Kabak et al. 2002).
REACT_118856 (Reactome) SKP:Cul:F-box (SCF) complexes containing F-box factors Beta-TrCP1 (BTRCP, E3RSIkappaB) or beta-TrCP2 (BTRCP2, FBXW11, HOS) bind IkappaB (Yaron et al. 1998, Fuchs et al. 1999, Suzuki et al. 1999, Tan et al. 1999, Winston et al. 1999, Wu and Ghosh 1999).
REACT_12008 (Reactome) The IP3 receptor (IP3R) is an IP3-gated calcium channel. It is a large, homotetrameric protein, similar to other calcium channel proteins such as ryanodine. The four subunits form a 'four-leafed clover' structure arranged around the central calcium channel. Binding of ligands such as IP3 results in conformational changes in the receptor's structure that leads to channel opening.
REACT_12074 (Reactome) IP3 promotes the release of intracellular calcium.
REACT_12602 (Reactome) Upon increase in calcium concentration, calmodulin (CaM) is activated by binding to four calcium ions.
REACT_23904 (Reactome) Sustained calcium signalling in lymphocytes and platelets requires the uptake of extracellular calcium when intracellular stores are depleted. The process whereby intracellular calcium depletion stimulates calcium uptake is often referred to as Store-operated calcium entry (SOCE). Store depletion is sensed by stromal interaction molecule 1 (STIM1), which then translocates to the plasma membrane and associates with 2 dimers of Orai1 to form a calcium-release activated calcium (CRAC) channel.
REACT_23967 (Reactome) Activation of Calcium-release-activated (CRAC) channels allows influx of calcium. The Orai component of CRAC is responsible for the selectivity of the channel, while the Stim component is responsible for activation.
RasGRP1/3REACT_118733 (Reactome)
SCF-beta-TrCp1/2ArrowREACT_118619 (Reactome)
SCF-beta-TrCp1/2REACT_118856 (Reactome)
SHC1 p46/p52REACT_118566 (Reactome)
STIM1 DimerArrowREACT_118808 (Reactome)
STIM1 DimerREACT_118759 (Reactome)
STIM1 DimerREACT_23904 (Reactome)
STIM1:CalciumREACT_118808 (Reactome)
STIM1:TRPC1ArrowREACT_118759 (Reactome)
STIM1:TRPC1mim-catalysisREACT_118688 (Reactome)
SYKREACT_118749 (Reactome)
TRPC1REACT_118759 (Reactome)
UbREACT_118619 (Reactome)
VAV1REACT_118566 (Reactome)
p-BCL10REACT_118777 (Reactome)
p-CARMA1 OligomerArrowREACT_118598 (Reactome)
p-CARMA1 OligomerREACT_118777 (Reactome)
p-RasGRP1,3:DAGArrowREACT_118733 (Reactome)
p-RasGRP1,3:DAGmim-catalysisREACT_118807 (Reactome)
p21 RAS:GDPREACT_118807 (Reactome)
p21 RAS:GTPArrowREACT_118807 (Reactome)
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