Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)

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1. Hutten S, Kehlenbach RH.; ''CRM1-mediated nuclear export: to the pore and beyond.''; PubMed Europe PMC Scholia
2. Lévesque L, Guzik B, Guan T, Coyle J, Black BE, Rekosh D, Hammarskjöld ML, Paschal BM.; ''RNA export mediated by tap involves NXT1-dependent interactions with the nuclear pore complex.''; PubMed Europe PMC Scholia
3. Coltri P, Effenberger K, Chalkley RJ, Burlingame AL, Jurica MS.; ''Breaking up the C complex spliceosome shows stable association of proteins with the lariat intron intermediate.''; PubMed Europe PMC Scholia
4. Zhou Z, Licklider LJ, Gygi SP, Reed R.; ''Comprehensive proteomic analysis of the human spliceosome.''; PubMed Europe PMC Scholia
5. Le Hir H, Izaurralde E, Maquat LE, Moore MJ.; ''The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions.''; PubMed Europe PMC Scholia
6. Ma XM, Yoon SO, Richardson CJ, Jülich K, Blenis J.; ''SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs.''; PubMed Europe PMC Scholia
7. Ajuh P, Sleeman J, Chusainow J, Lamond AI.; ''A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing.''; PubMed Europe PMC Scholia
8. Hegele A, Kamburov A, Grossmann A, Sourlis C, Wowro S, Weimann M, Will CL, Pena V, Lührmann R, Stelzl U.; ''Dynamic protein-protein interaction wiring of the human spliceosome.''; PubMed Europe PMC Scholia
9. Pikielny CW, Bindereif A, Green MR.; ''In vitro reconstitution of snRNPs: a reconstituted U4/U6 snRNP participates in splicing complex formation.''; PubMed Europe PMC Scholia
10. Kataoka N, Dreyfuss G.; ''A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex.''; PubMed Europe PMC Scholia
11. Hung ML, Hautbergue GM, Snijders AP, Dickman MJ, Wilson SA.; ''Arginine methylation of REF/ALY promotes efficient handover of mRNA to TAP/NXF1.''; PubMed Europe PMC Scholia
12. Cronshaw JM, Krutchinsky AN, Zhang W, Chait BT, Matunis MJ.; ''Proteomic analysis of the mammalian nuclear pore complex.''; PubMed Europe PMC Scholia
13. Suyama M, Doerks T, Braun IC, Sattler M, Izaurralde E, Bork P.; ''Prediction of structural domains of TAP reveals details of its interaction with p15 and nucleoporins.''; PubMed Europe PMC Scholia
14. Grote M, Wolf E, Will CL, Lemm I, Agafonov DE, Schomburg A, Fischle W, Urlaub H, Lührmann R.; ''Molecular architecture of the human Prp19/CDC5L complex.''; PubMed Europe PMC Scholia
15. Moore CL, Sharp PA.; ''Accurate cleavage and polyadenylation of exogenous RNA substrate.''; PubMed Europe PMC Scholia
16. Blencowe BJ, Baurén G, Eldridge AG, Issner R, Nickerson JA, Rosonina E, Sharp PA.; ''The SRm160/300 splicing coactivator subunits.''; PubMed Europe PMC Scholia
17. Le Hir H, Gatfield D, Izaurralde E, Moore MJ.; ''The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay.''; PubMed Europe PMC Scholia
18. Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L, Jia G, Yu M, Lu Z, Deng X, Dai Q, Chen W, He C.; ''A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.''; PubMed Europe PMC Scholia
19. Bokar JA, Shambaugh ME, Polayes D, Matera AG, Rottman FM.; ''Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase.''; PubMed Europe PMC Scholia
20. Lindtner S, Felber BK, Kjems J.; ''An element in the 3' untranslated region of human LINE-1 retrotransposon mRNA binds NXF1(TAP) and can function as a nuclear export element.''; PubMed Europe PMC Scholia
21. Katahira J, Straesser K, Saiwaki T, Yoneda Y, Hurt E.; ''Complex formation between Tap and p15 affects binding to FG-repeat nucleoporins and nucleocytoplasmic shuttling.''; PubMed Europe PMC Scholia
22. Chi B, Wang Q, Wu G, Tan M, Wang L, Shi M, Chang X, Cheng H.; ''Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA.''; PubMed Europe PMC Scholia
23. Ilagan JO, Chalkley RJ, Burlingame AL, Jurica MS.; ''Rearrangements within human spliceosomes captured after exon ligation.''; PubMed Europe PMC Scholia
24. Makarov EM, Owen N, Bottrill A, Makarova OV.; ''Functional mammalian spliceosomal complex E contains SMN complex proteins in addition to U1 and U2 snRNPs.''; PubMed Europe PMC Scholia
25. Suntharalingam M, Wente SR.; ''Peering through the pore: nuclear pore complex structure, assembly, and function.''; PubMed Europe PMC Scholia
26. Ping XL, Sun BF, Wang L, Xiao W, Yang X, Wang WJ, Adhikari S, Shi Y, Lv Y, Chen YS, Zhao X, Li A, Yang Y, Dahal U, Lou XM, Liu X, Huang J, Yuan WP, Zhu XF, Cheng T, Zhao YL, Wang X, Rendtlew Danielsen JM, Liu F, Yang YG.; ''Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase.''; PubMed Europe PMC Scholia
27. Zhou Z, Luo MJ, Straesser K, Katahira J, Hurt E, Reed R.; ''The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans.''; PubMed Europe PMC Scholia
28. Cheng H, Dufu K, Lee CS, Hsu JL, Dias A, Reed R.; ''Human mRNA export machinery recruited to the 5' end of mRNA.''; PubMed Europe PMC Scholia
29. Yamazaki T, Fujiwara N, Yukinaga H, Ebisuya M, Shiki T, Kurihara T, Kioka N, Kambe T, Nagao M, Nishida E, Masuda S.; ''The closely related RNA helicases, UAP56 and URH49, preferentially form distinct mRNA export machineries and coordinately regulate mitotic progression.''; PubMed Europe PMC Scholia
30. Makarov EM, Makarova OV, Urlaub H, Gentzel M, Will CL, Wilm M, Lührmann R.; ''Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome.''; PubMed Europe PMC Scholia
31. Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R.; ''Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein.''; PubMed Europe PMC Scholia
32. Schwartz S, Mumbach MR, Jovanovic M, Wang T, Maciag K, Bushkin GG, Mertins P, Ter-Ovanesyan D, Habib N, Cacchiarelli D, Sanjana NE, Freinkman E, Pacold ME, Satija R, Mikkelsen TS, Hacohen N, Zhang F, Carr SA, Lander ES, Regev A.; ''Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites.''; PubMed Europe PMC Scholia
33. Wu Q, Krainer AR.; ''AT-AC pre-mRNA splicing mechanisms and conservation of minor introns in voltage-gated ion channel genes.''; PubMed Europe PMC Scholia
34. Carmody SR, Wente SR.; ''mRNA nuclear export at a glance.''; PubMed Europe PMC Scholia
35. Valadkhan S, Manley JL.; ''Splicing-related catalysis by protein-free snRNAs.''; PubMed Europe PMC Scholia
36. Kabachinski G, Schwartz TU.; ''The nuclear pore complex--structure and function at a glance.''; PubMed Europe PMC Scholia
37. Lévesque L, Bor YC, Matzat LH, Jin L, Berberoglu S, Rekosh D, Hammarskjöld ML, Paschal BM.; ''Mutations in tap uncouple RNA export activity from translocation through the nuclear pore complex.''; PubMed Europe PMC Scholia
38. Ruskin B, Krainer AR, Maniatis T, Green MR.; ''Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro.''; PubMed Europe PMC Scholia
39. Bessonov S, Anokhina M, Krasauskas A, Golas MM, Sander B, Will CL, Urlaub H, Stark H, Lührmann R.; ''Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis.''; PubMed Europe PMC Scholia
40. Lamond AI, Konarska MM, Grabowski PJ, Sharp PA.; ''Spliceosome assembly involves the binding and release of U4 small nuclear ribonucleoprotein.''; PubMed Europe PMC Scholia
41. Teng IF, Wilson SA.; ''Mapping interactions between mRNA export factors in living cells.''; PubMed Europe PMC Scholia
42. Ori A, Banterle N, Iskar M, Iskar M, Andrés-Pons A, Escher C, Khanh Bui H, Sparks L, Solis-Mezarino V, Rinner O, Bork P, Lemke EA, Beck M.; ''Cell type-specific nuclear pores: a case in point for context-dependent stoichiometry of molecular machines.''; PubMed Europe PMC Scholia
43. Culjkovic-Kraljacic B, Borden KL.; ''Aiding and abetting cancer: mRNA export and the nuclear pore.''; PubMed Europe PMC Scholia
44. Shepard J, Reick M, Olson S, Graveley BR.; ''Characterization of U2AF(6), a splicing factor related to U2AF(35).''; PubMed Europe PMC Scholia
45. Charlesworth A, Meijer HA, de Moor CH.; ''Specificity factors in cytoplasmic polyadenylation.''; PubMed Europe PMC Scholia
46. Rappsilber J, Ryder U, Lamond AI, Mann M.; ''Large-scale proteomic analysis of the human spliceosome.''; PubMed Europe PMC Scholia
47. Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI.; ''Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry.''; PubMed Europe PMC Scholia
48. Brahms H, Meheus L, de Brabandere V, Fischer U, Lührmann R.; ''Symmetrical dimethylation of arginine residues in spliceosomal Sm protein B/B' and the Sm-like protein LSm4, and their interaction with the SMN protein.''; PubMed Europe PMC Scholia
49. Wiegand HL, Coburn GA, Zeng Y, Kang Y, Bogerd HP, Cullen BR.; ''Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes.''; PubMed Europe PMC Scholia
50. Wagner S, Chiosea S, Ivshina M, Nickerson JA.; ''In vitro FRAP reveals the ATP-dependent nuclear mobilization of the exon junction complex protein SRm160.''; PubMed Europe PMC Scholia
51. Rabut G, Doye V, Ellenberg J.; ''Mapping the dynamic organization of the nuclear pore complex inside single living cells.''; PubMed Europe PMC Scholia
52. Erkmann JA, Kutay U.; ''Nuclear export of mRNA: from the site of transcription to the cytoplasm.''; PubMed Europe PMC Scholia
53. Kang Y, Bogerd HP, Yang J, Cullen BR.; ''Analysis of the RNA binding specificity of the human tap protein, a constitutive transport element-specific nuclear RNA export factor.''; PubMed Europe PMC Scholia
54. Watkins JL, Murphy R, Emtage JL, Wente SR.; ''The human homologue of Saccharomyces cerevisiae Gle1p is required for poly(A)+ RNA export.''; PubMed Europe PMC Scholia
55. Schönemann L, Kühn U, Martin G, Schäfer P, Gruber AR, Keller W, Zavolan M, Wahle E.; ''Reconstitution of CPSF active in polyadenylation: recognition of the polyadenylation signal by WDR33.''; PubMed Europe PMC Scholia
56. Meinel DM, Burkert-Kautzsch C, Kieser A, O'Duibhir E, Siebert M, Mayer A, Cramer P, Söding J, Holstege FC, Sträßer K.; ''Recruitment of TREX to the transcription machinery by its direct binding to the phospho-CTD of RNA polymerase II.''; PubMed Europe PMC Scholia
57. Lin-Moshier Y, Sebastian PJ, Higgins L, Sampson ND, Hewitt JE, Marchant JS.; ''Re-evaluation of the role of calcium homeostasis endoplasmic reticulum protein (CHERP) in cellular calcium signaling.''; PubMed Europe PMC Scholia
58. Viphakone N, Cumberbatch MG, Livingstone MJ, Heath PR, Dickman MJ, Catto JW, Wilson SA.; ''Luzp4 defines a new mRNA export pathway in cancer cells.''; PubMed Europe PMC Scholia
59. Valadkhan S, Mohammadi A, Wachtel C, Manley JL.; ''Protein-free spliceosomal snRNAs catalyze a reaction that resembles the first step of splicing.''; PubMed Europe PMC Scholia
60. Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M.; ''Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex.''; PubMed Europe PMC Scholia
61. Kang Y, Cullen BR.; ''The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences.''; PubMed Europe PMC Scholia
62. Madan V, Kanojia D, Li J, Okamoto R, Sato-Otsubo A, Kohlmann A, Sanada M, Grossmann V, Sundaresan J, Shiraishi Y, Miyano S, Thol F, Ganser A, Yang H, Haferlach T, Ogawa S, Koeffler HP.; ''Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome.''; PubMed Europe PMC Scholia
63. Folco EG, Lee CS, Dufu K, Yamazaki T, Reed R.; ''The proteins PDIP3 and ZC11A associate with the human TREX complex in an ATP-dependent manner and function in mRNA export.''; PubMed Europe PMC Scholia
64. Hautbergue GM, Hung ML, Golovanov AP, Lian LY, Wilson SA.; ''Mutually exclusive interactions drive handover of mRNA from export adaptors to TAP.''; PubMed Europe PMC Scholia
65. Hastings ML, Krainer AR.; ''Functions of SR proteins in the U12-dependent AT-AC pre-mRNA splicing pathway.''; PubMed Europe PMC Scholia
66. Golovanov AP, Hautbergue GM, Tintaru AM, Lian LY, Wilson SA.; ''The solution structure of REF2-I reveals interdomain interactions and regions involved in binding mRNA export factors and RNA.''; PubMed Europe PMC Scholia
67. Deckert J, Hartmuth K, Boehringer D, Behzadnia N, Will CL, Kastner B, Stark H, Urlaub H, Lührmann R.; ''Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions.''; PubMed Europe PMC Scholia
68. Yoshimoto R, Kataoka N, Okawa K, Ohno M.; ''Isolation and characterization of post-splicing lariat-intron complexes.''; PubMed Europe PMC Scholia
69. Box JA, Bunch JT, Tang W, Baumann P.; ''Spliceosomal cleavage generates the 3' end of telomerase RNA.''; PubMed Europe PMC Scholia
70. Johnson SA, Kim H, Erickson B, Bentley DL.; ''The export factor Yra1 modulates mRNA 3' end processing.''; PubMed Europe PMC Scholia
71. Bachi A, Braun IC, Rodrigues JP, Panté N, Ribbeck K, von Kobbe C, Kutay U, Wilm M, Görlich D, Carmo-Fonseca M, Izaurralde E.; ''The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates.''; PubMed Europe PMC Scholia
72. Strässer K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, Rodriguez-Navarro S, Rondón AG, Aguilera A, Struhl K, Reed R, Hurt E.; ''TREX is a conserved complex coupling transcription with messenger RNA export.''; PubMed Europe PMC Scholia
73. Chang CT, Hautbergue GM, Walsh MJ, Viphakone N, van Dijk TB, Philipsen S, Wilson SA.; ''Chtop is a component of the dynamic TREX mRNA export complex.''; PubMed Europe PMC Scholia
74. Fontoura BM, Blobel G, Matunis MJ.; ''A conserved biogenesis pathway for nucleoporins: proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96.''; PubMed Europe PMC Scholia
75. Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ.; ''Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.''; PubMed Europe PMC Scholia
76. Crisci A, Raleff F, Bagdiul I, Raabe M, Urlaub H, Rain JC, Krämer A.; ''Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins.''; PubMed Europe PMC Scholia
77. Shi Y, Di Giammartino DC, Taylor D, Sarkeshik A, Rice WJ, Yates JR, Frank J, Manley JL.; ''Molecular architecture of the human pre-mRNA 3' processing complex.''; PubMed Europe PMC Scholia
78. Takagaki Y, Manley JL.; ''Complex protein interactions within the human polyadenylation machinery identify a novel component.''; PubMed Europe PMC Scholia
79. Kreivi JP, Lamond AI.; ''RNA splicing: unexpected spliceosome diversity.''; PubMed Europe PMC Scholia
80. Katahira J.; ''Nuclear export of messenger RNA.''; PubMed Europe PMC Scholia
81. Rougemaille M, Dieppois G, Kisseleva-Romanova E, Gudipati RK, Lemoine S, Blugeon C, Boulay J, Jensen TH, Stutz F, Devaux F, Libri D.; ''THO/Sub2p functions to coordinate 3'-end processing with gene-nuclear pore association.''; PubMed Europe PMC Scholia
82. Luna R, Rondón AG, Aguilera A.; ''New clues to understand the role of THO and other functionally related factors in mRNP biogenesis.''; PubMed Europe PMC Scholia
83. Zaric B, Chami M, Rémigy H, Engel A, Ballmer-Hofer K, Winkler FK, Kambach C.; ''Reconstitution of two recombinant LSm protein complexes reveals aspects of their architecture, assembly, and function.''; PubMed Europe PMC Scholia
84. Zhao J, Hyman L, Moore C.; ''Formation of mRNA 3' ends in eukaryotes: mechanism, regulation, and interrelationships with other steps in mRNA synthesis.''; PubMed Europe PMC Scholia
85. Lejeune F, Ishigaki Y, Li X, Maquat LE.; ''The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling.''; PubMed Europe PMC Scholia
86. Degot S, Le Hir H, Alpy F, Kedinger V, Stoll I, Wendling C, Seraphin B, Rio MC, Tomasetto C.; ''Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module.''; PubMed Europe PMC Scholia
87. Daguenet E, Baguet A, Degot S, Schmidt U, Alpy F, Wendling C, Spiegelhalter C, Kessler P, Rio MC, Le Hir H, Bertrand E, Tomasetto C.; ''Perispeckles are major assembly sites for the exon junction core complex.''; PubMed Europe PMC Scholia
88. Braun IC, Herold A, Rode M, Conti E, Izaurralde E.; ''Overexpression of TAP/p15 heterodimers bypasses nuclear retention and stimulates nuclear mRNA export.''; PubMed Europe PMC Scholia
89. Masuda S, Das R, Cheng H, Hurt E, Dorman N, Reed R.; ''Recruitment of the human TREX complex to mRNA during splicing.''; PubMed Europe PMC Scholia
90. Harris ME, Böhni R, Schneiderman MH, Ramamurthy L, Schümperli D, Marzluff WF.; ''Regulation of histone mRNA in the unperturbed cell cycle: evidence suggesting control at two posttranscriptional steps.''; PubMed Europe PMC Scholia
91. Hautbergue GM, Hung ML, Walsh MJ, Snijders AP, Chang CT, Jones R, Ponting CP, Dickman MJ, Wilson SA.; ''UIF, a New mRNA export adaptor that works together with REF/ALY, requires FACT for recruitment to mRNA.''; PubMed Europe PMC Scholia
92. Guzik BW, Levesque L, Prasad S, Bor YC, Black BE, Paschal BM, Rekosh D, Hammarskjöld ML.; ''NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells.''; PubMed Europe PMC Scholia
93. von Moeller H, Lerner R, Ricciardi A, Basquin C, Marzluff WF, Conti E.; ''Structural and biochemical studies of SLIP1-SLBP identify DBP5 and eIF3g as SLIP1-binding proteins.''; PubMed Europe PMC Scholia
94. Dreyfuss G, Matunis MJ, Piñol-Roma S, Burd CG.; ''hnRNP proteins and the biogenesis of mRNA.''; PubMed Europe PMC Scholia
95. Rondón AG, Jimeno S, García-Rubio M, Aguilera A.; ''Molecular evidence that the eukaryotic THO/TREX complex is required for efficient transcription elongation.''; PubMed Europe PMC Scholia
96. Steckelberg AL, Boehm V, Gromadzka AM, Gehring NH.; ''CWC22 connects pre-mRNA splicing and exon junction complex assembly.''; PubMed Europe PMC Scholia
97. Gencheva M, Kato M, Newo AN, Lin RJ.; ''Contribution of DEAH-box protein DHX16 in human pre-mRNA splicing.''; PubMed Europe PMC Scholia
98. Dufu K, Livingstone MJ, Seebacher J, Gygi SP, Wilson SA, Reed R.; ''ATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complex.''; PubMed Europe PMC Scholia
99. Lin DH, Stuwe T, Schilbach S, Rundlet EJ, Perriches T, Mobbs G, Fan Y, Thierbach K, Huber FM, Collins LN, Davenport AM, Jeon YE, Hoelz A.; ''Architecture of the symmetric core of the nuclear pore.''; PubMed Europe PMC Scholia
100. Hartmuth K, Urlaub H, Vornlocher HP, Will CL, Gentzel M, Wilm M, Lührmann R.; ''Protein composition of human prespliceosomes isolated by a tobramycin affinity-selection method.''; PubMed Europe PMC Scholia
101. Grzybowska EA.; ''Human intronless genes: functional groups, associated diseases, evolution, and mRNA processing in absence of splicing.''; PubMed Europe PMC Scholia
102. Yao C, Choi EA, Weng L, Xie X, Wan J, Xing Y, Moresco JJ, Tu PG, Yates JR, Shi Y.; ''Overlapping and distinct functions of CstF64 and CstF64τ in mammalian mRNA 3' processing.''; PubMed Europe PMC Scholia
103. Reichert VL, Le Hir H, Jurica MS, Moore MJ.; ''5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly.''; PubMed Europe PMC Scholia
104. Katahira J, Strässer K, Podtelejnikov A, Mann M, Jung JU, Hurt E.; ''The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human.''; PubMed Europe PMC Scholia
105. Kaufmann I, Martin G, Friedlein A, Langen H, Keller W.; ''Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase.''; PubMed Europe PMC Scholia
106. Wente SR, Rout MP.; ''The nuclear pore complex and nuclear transport.''; PubMed Europe PMC Scholia
107. Viphakone N, Hautbergue GM, Walsh M, Chang CT, Holland A, Folco EG, Reed R, Wilson SA.; ''TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export.''; PubMed Europe PMC Scholia
108. Will CL, Schneider C, Hossbach M, Urlaub H, Rauhut R, Elbashir S, Tuschl T, Lührmann R.; ''The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.''; PubMed Europe PMC Scholia
109. Kosinski J, Mosalaganti S, von Appen A, Teimer R, DiGuilio AL, Wan W, Bui KH, Hagen WJ, Briggs JA, Glavy JS, Hurt E, Beck M.; ''Molecular architecture of the inner ring scaffold of the human nuclear pore complex.''; PubMed Europe PMC Scholia
110. Behzadnia N, Golas MM, Hartmuth K, Sander B, Kastner B, Deckert J, Dube P, Will CL, Urlaub H, Stark H, Lührmann R.; ''Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes.''; PubMed Europe PMC Scholia
111. Herold A, Suyama M, Rodrigues JP, Braun IC, Kutay U, Carmo-Fonseca M, Bork P, Izaurralde E.; ''TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture.''; PubMed Europe PMC Scholia
112. Taniguchi I, Ohno M.; ''ATP-dependent recruitment of export factor Aly/REF onto intronless mRNAs by RNA helicase UAP56.''; PubMed Europe PMC Scholia
113. Kota KP, Wagner SR, Huerta E, Underwood JM, Nickerson JA.; ''Binding of ATP to UAP56 is necessary for mRNA export.''; PubMed Europe PMC Scholia
114. Padgett RA, Konarska MM, Grabowski PJ, Hardy SF, Sharp PA.; ''Lariat RNA's as intermediates and products in the splicing of messenger RNA precursors.''; PubMed Europe PMC Scholia
115. Shen H, Zheng X, Luecke S, Green MR.; ''The U2AF35-related protein Urp contacts the 3' splice site to promote U12-type intron splicing and the second step of U2-type intron splicing.''; PubMed Europe PMC Scholia
116. Wahle E, Rüegsegger U.; ''3'-End processing of pre-mRNA in eukaryotes.''; PubMed Europe PMC Scholia
117. Grüter P, Tabernero C, von Kobbe C, Schmitt C, Saavedra C, Bachi A, Wilm M, Felber BK, Izaurralde E.; ''TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus.''; PubMed Europe PMC Scholia
118. Bessonov S, Anokhina M, Will CL, Urlaub H, Lührmann R.; ''Isolation of an active step I spliceosome and composition of its RNP core.''; PubMed Europe PMC Scholia
119. Singh J, Sikand K, Conrad H, Will CL, Komar AA, Shukla GC.; ''U6atac snRNA stem-loop interacts with U12 p65 RNA binding protein and is functionally interchangeable with the U12 apical stem-loop III.''; PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	115088	view	17:03, 25 January 2021	ReactomeTeam	Reactome version 75
	113530	view	12:00, 2 November 2020	ReactomeTeam	Reactome version 74
	112728	view	16:13, 9 October 2020	ReactomeTeam	Reactome version 73
	101644	view	11:51, 1 November 2018	ReactomeTeam	reactome version 66
	101180	view	21:38, 31 October 2018	ReactomeTeam	reactome version 65
	100706	view	20:10, 31 October 2018	ReactomeTeam	reactome version 64
	100256	view	16:56, 31 October 2018	ReactomeTeam	reactome version 63
	99809	view	15:20, 31 October 2018	ReactomeTeam	reactome version 62 (2nd attempt)
	93917	view	13:44, 16 August 2017	ReactomeTeam	reactome version 61
	93494	view	11:25, 9 August 2017	ReactomeTeam	reactome version 61
	88115	view	10:05, 26 July 2016	Ryanmiller	Ontology Term : 'regulatory pathway' added !
	86590	view	09:21, 11 July 2016	ReactomeTeam	reactome version 56
	83367	view	11:01, 18 November 2015	ReactomeTeam	Version54
	81532	view	13:04, 21 August 2015	ReactomeTeam	Version53
	77003	view	08:29, 17 July 2014	ReactomeTeam	Fixed remaining interactions
	76708	view	12:07, 16 July 2014	ReactomeTeam	Fixed remaining interactions
	76034	view	10:09, 11 June 2014	ReactomeTeam	Re-fixing comment source
	75743	view	11:23, 10 June 2014	ReactomeTeam	Reactome 48 Update
	75093	view	14:04, 8 May 2014	Anwesha	Fixing comment source for displaying WikiPathways description
	74829	view	10:05, 30 April 2014	ReactomeTeam	Reactome46
	74740	view	08:49, 30 April 2014	ReactomeTeam	Reactome46
	42105	view	21:57, 4 March 2011	MaintBot	Automatic update
	39915	view	05:56, 21 January 2011	MaintBot	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
2xMe-SNRPB [nucleoplasm]	Protein	P14678 (Uniprot-TrEMBL)
2xMe-SNRPD1 [nucleoplasm]	Protein	P62314 (Uniprot-TrEMBL)
2xMe-SNRPD3 [nucleoplasm]	Protein	P62318 (Uniprot-TrEMBL)
3' end cleaved, ligated exon containing complex	Complex	REACT_3092 (Reactome)
3'-polyadenylated, capped mRNA complex	Complex	REACT_5827 (Reactome)
AAAS [nuclear envelope]	Protein	Q9NRG9 (Uniprot-TrEMBL)
ALYREF [cytosol]	Protein	Q86V81 (Uniprot-TrEMBL)
ALYREF [nucleoplasm]	Protein	Q86V81 (Uniprot-TrEMBL)
ALYREF	Protein	Q86V81 (Uniprot-TrEMBL)
ASR2B		REACT_5122 (Reactome)
ATAC A Complex	Complex	REACT_4037 (Reactome)
ATAC B Complex	Complex	REACT_5095 (Reactome)
ATAC C Complex with lariat containing 5'-end cleaved mRNA	Complex	REACT_5134 (Reactome)
ATAC C Complex	Complex	REACT_4626 (Reactome)
ATP	Metabolite	CHEBI:15422 (ChEBI)
CC1.3 protein /3 RRM, RS		REACT_4848 (Reactome)
CCAR1 [nucleoplasm]	Protein	Q8IX12 (Uniprot-TrEMBL)
CCAR1	Protein	Q8IX12 (Uniprot-TrEMBL)
CD2BP2 [nucleoplasm]	Protein	O95400 (Uniprot-TrEMBL)
CD2BP2	Protein	O95400 (Uniprot-TrEMBL)
CDC40 [nucleoplasm]	Protein	O60508 (Uniprot-TrEMBL)
CDC40	Protein	O60508 (Uniprot-TrEMBL)
CF II	Complex	REACT_3772 (Reactome)
CF I	Complex	REACT_4896 (Reactome)
CLP1 [nucleoplasm]	Protein	Q92989 (Uniprot-TrEMBL)
CPSF1 [nucleoplasm]	Protein	Q10570 (Uniprot-TrEMBL)
CPSF2 [nucleoplasm]	Protein	Q9P2I0 (Uniprot-TrEMBL)
CPSF3 [nucleoplasm]	Protein	Q9UKF6 (Uniprot-TrEMBL)
CPSF7 [nucleoplasm]	Protein	Q8N684 (Uniprot-TrEMBL)
CPSF	Complex	REACT_4530 (Reactome)
CSTF1 [nucleoplasm]	Protein	Q05048 (Uniprot-TrEMBL)
CSTF2(2-577) [nucleoplasm]	Protein	P33240 (Uniprot-TrEMBL)
CSTF3 [nucleoplasm]	Protein	Q12996 (Uniprot-TrEMBL)
Cap Binding Complex (CBC)	Complex	REACT_3884 (Reactome)
Cleavage and Polyadenylation Complex	Complex	REACT_3144 (Reactome)
CstF	Complex	REACT_3503 (Reactome)
DDX23 [nucleoplasm]	Protein	Q9BUQ8 (Uniprot-TrEMBL)
DHX38 [nucleoplasm]	Protein	Q92620 (Uniprot-TrEMBL)
DHX38	Protein	Q92620 (Uniprot-TrEMBL)
DHX9 [nucleoplasm]	Protein	Q08211 (Uniprot-TrEMBL)
DHX9	Protein	Q08211 (Uniprot-TrEMBL)
DNAJC8(2-253) [nucleoplasm]	Protein	O75937 (Uniprot-TrEMBL)
DNAJC8(2-253)	Protein	O75937 (Uniprot-TrEMBL)
DnaJ hom. NP_055602		REACT_4415 (Reactome)
EFTUD2 [nucleoplasm]	Protein	Q15029 (Uniprot-TrEMBL)
EIF4E [cytosol]	Protein	P06730 (Uniprot-TrEMBL)
EIF4E	Protein	P06730 (Uniprot-TrEMBL)
Exon Junction Complex	Complex	REACT_2984 (Reactome)
Export Receptor bound mature mRNA Complex	Complex	REACT_2455 (Reactome)
Export Receptor bound mature mRNA Complex	Complex	REACT_2624 (Reactome)
FUS [nucleoplasm]	Protein	P35637 (Uniprot-TrEMBL)
FUS	Protein	P35637 (Uniprot-TrEMBL)
GTF2F1(2-517) [nucleoplasm]	Protein	P35269 (Uniprot-TrEMBL)
GTF2F2(2-249) [nucleoplasm]	Protein	P13984 (Uniprot-TrEMBL)
HNRNPA0 [nucleoplasm]	Protein	Q13151 (Uniprot-TrEMBL)
HNRNPA0	Protein	Q13151 (Uniprot-TrEMBL)
HNRNPA1 [nucleoplasm]	Protein	P09651 (Uniprot-TrEMBL)
HNRNPA1	Protein	P09651 (Uniprot-TrEMBL)
HNRNPA2B1 [nucleoplasm]	Protein	P22626 (Uniprot-TrEMBL)
HNRNPA2B1	Protein	P22626 (Uniprot-TrEMBL)
HNRNPA3 [nucleoplasm]	Protein	P51991 (Uniprot-TrEMBL)
HNRNPA3	Protein	P51991 (Uniprot-TrEMBL)
HNRNPC [nucleoplasm]	Protein	P07910 (Uniprot-TrEMBL)
HNRNPC	Protein	P07910 (Uniprot-TrEMBL)
HNRNPD [nucleoplasm]	Protein	Q14103 (Uniprot-TrEMBL)
HNRNPD	Protein	Q14103 (Uniprot-TrEMBL)
HNRNPF(1-415) [nucleoplasm]	Protein	P52597 (Uniprot-TrEMBL)
HNRNPF(1-415)	Protein	P52597 (Uniprot-TrEMBL)
HNRNPH1(1-449) [nucleoplasm]	Protein	P31943 (Uniprot-TrEMBL)
HNRNPH1(1-449)	Protein	P31943 (Uniprot-TrEMBL)
HNRNPH2 [nucleoplasm]	Protein	P55795 (Uniprot-TrEMBL)
HNRNPH2	Protein	P55795 (Uniprot-TrEMBL)
HNRNPK [nucleoplasm]	Protein	P61978 (Uniprot-TrEMBL)
HNRNPK	Protein	P61978 (Uniprot-TrEMBL)
HNRNPL [nucleoplasm]	Protein	P14866 (Uniprot-TrEMBL)
HNRNPL	Protein	P14866 (Uniprot-TrEMBL)
HNRNPM [nucleoplasm]	Protein	P52272 (Uniprot-TrEMBL)
HNRNPM	Protein	P52272 (Uniprot-TrEMBL)
HNRNPR [nucleoplasm]	Protein	O43390 (Uniprot-TrEMBL)
HNRNPR	Protein	O43390 (Uniprot-TrEMBL)
HNRNPU [nucleoplasm]	Protein	Q00839 (Uniprot-TrEMBL)
HNRNPUL1 [nucleoplasm]	Protein	Q9BUJ2 (Uniprot-TrEMBL)
HNRNPUL1	Protein	Q9BUJ2 (Uniprot-TrEMBL)
HNRNPU	Protein	Q00839 (Uniprot-TrEMBL)
HuR /3 RRM protein		REACT_5767 (Reactome)
LSM2 [nucleoplasm]	Protein	Q9Y333 (Uniprot-TrEMBL)
Ligated exon containing complex	Complex	REACT_5472 (Reactome)
MAGOH [cytosol]	Protein	P61326 (Uniprot-TrEMBL)
MAGOH [nucleoplasm]	Protein	P61326 (Uniprot-TrEMBL)
METTL3 [nucleoplasm]	Protein	Q86U44 (Uniprot-TrEMBL)
Magoh-Y14 complex	Complex	REACT_5524 (Reactome)
Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex	Complex	REACT_4560 (Reactome)
Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref complex	Complex	REACT_5697 (Reactome)
Mature Intronless Transcript Derived mRNA:eIF4E Complex	Complex	REACT_3252 (Reactome)
Mature Intronless transcript derived Histone mRNA:SLBP:CBP80:CBP20	Complex	REACT_3802 (Reactome)
Mature SLBP independent Histone mRNA:eIF4E complex	Complex	REACT_3452 (Reactome)
Mature intronless derived mRNA:TAP:Aly/Ref complex	Complex	REACT_4662 (Reactome)
Mature intronless derived mRNA complex	Complex	REACT_4047 (Reactome)
Mature intronless transcript derived Histone mRNA:SLBP:TAP:Aly/Ref complex	Complex	REACT_2791 (Reactome)
Mature intronless transcript derived Histone mRNA:SLBP:TAP:Aly/Ref complex	Complex	REACT_3824 (Reactome)
Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex	Complex	REACT_2270 (Reactome)
Mature intronless transcript derived Histone pre-mRNA:CBC complex	Complex	REACT_5592 (Reactome)
Mature mRNP Complex	Complex	REACT_4851 (Reactome)
NCBP1 [cytosol]	Protein	Q09161 (Uniprot-TrEMBL)
NCBP1 [nucleoplasm]	Protein	Q09161 (Uniprot-TrEMBL)
NCBP1	Protein	Q09161 (Uniprot-TrEMBL)
NCBP2 [cytosol]	Protein	P52298 (Uniprot-TrEMBL)
NCBP2 [nucleoplasm]	Protein	P52298 (Uniprot-TrEMBL)
NCBP2	Protein	P52298 (Uniprot-TrEMBL)
NFAR-2 protein		REACT_4072 (Reactome)
NFX.1 [cytosol]	Protein	O43831 (Uniprot-TrEMBL)
NFX.1 [nucleoplasm]	Protein	O43831 (Uniprot-TrEMBL)
NFX.1	Protein	O43831 (Uniprot-TrEMBL)
NHP2L1 [nucleoplasm]	Protein	P55769 (Uniprot-TrEMBL)
NUDT21 [nucleoplasm]	Protein	O43809 (Uniprot-TrEMBL)
NUP107 [nuclear envelope]	Protein	P57740 (Uniprot-TrEMBL)
NUP133 [nuclear envelope]	Protein	Q8WUM0 (Uniprot-TrEMBL)
NUP153 [nucleoplasm]	Protein	P49790 (Uniprot-TrEMBL)
NUP155 [nuclear envelope]	Protein	O75694 (Uniprot-TrEMBL)
NUP160 [nuclear envelope]	Protein	Q12769 (Uniprot-TrEMBL)
NUP188(2-1749) [nuclear envelope]	Protein	Q5SRE5 (Uniprot-TrEMBL)
NUP205(2-2012) [nuclear envelope]	Protein	Q92621 (Uniprot-TrEMBL)
NUP210 [nuclear envelope]	Protein	Q8TEM1 (Uniprot-TrEMBL)
NUP214 [cytosol]	Protein	P35658 (Uniprot-TrEMBL)
NUP35 [nuclear envelope]	Protein	Q8NFH5 (Uniprot-TrEMBL)
NUP37 [nuclear envelope]	Protein	Q8NFH4 (Uniprot-TrEMBL)
NUP43 [nuclear envelope]	Protein	Q8NFH3 (Uniprot-TrEMBL)
NUP50 [nucleoplasm]	Protein	Q9UKX7 (Uniprot-TrEMBL)
NUP54 [nuclear envelope]	Protein	Q7Z3B4 (Uniprot-TrEMBL)
NUP62 [nuclear envelope]	Protein	P37198 (Uniprot-TrEMBL)
NUP85 [nuclear envelope]	Protein	Q9BW27 (Uniprot-TrEMBL)
NUP88 [cytosol]	Protein	Q99567 (Uniprot-TrEMBL)
NUP93 [nuclear envelope]	Protein	Q8N1F7 (Uniprot-TrEMBL)
NUP98-5 [nuclear envelope]	Protein	P52948-5 (Uniprot-TrEMBL)
NUPL1-2 [nuclear envelope]	Protein	Q9BVL2-1 (Uniprot-TrEMBL)
NUPL2 [cytosol]	Protein	O15504 (Uniprot-TrEMBL)
NXF1(2-619) [cytosol]	Protein	Q9UBU9 (Uniprot-TrEMBL)
NXF1(2-619) [nucleoplasm]	Protein	Q9UBU9 (Uniprot-TrEMBL)
NXF1(2-619)	Protein	Q9UBU9 (Uniprot-TrEMBL)
Nuclear Pore Complex (NPC)	Complex	REACT_5542 (Reactome)
Nucleoplasmic mature intronless derived mRNA:TAP:Aly/Ref complex	Complex	REACT_4247 (Reactome)
Nup45 [nuclear envelope]	Protein	Q9BVL2-2 (Uniprot-TrEMBL)
PABPN1 [nucleoplasm]	Protein	Q86U42 (Uniprot-TrEMBL)
PABPN1	Protein	Q86U42 (Uniprot-TrEMBL)
PAPOLA(2-745) [nucleoplasm]	Protein	P51003 (Uniprot-TrEMBL)
PAPOLA(2-745)	Protein	P51003 (Uniprot-TrEMBL)
PCBP1 [nucleoplasm]	Protein	Q15365 (Uniprot-TrEMBL)
PCBP1	Protein	Q15365 (Uniprot-TrEMBL)
PCBP2 [nucleoplasm]	Protein	Q15366 (Uniprot-TrEMBL)
PCBP2	Protein	Q15366 (Uniprot-TrEMBL)
PCF11 [nucleoplasm]	Protein	O94913 (Uniprot-TrEMBL)
PHF5A(1-110) [nucleoplasm]	Protein	Q7RTV0 (Uniprot-TrEMBL)
POLR2A [nucleoplasm]	Protein	P24928 (Uniprot-TrEMBL)
POLR2B [nucleoplasm]	Protein	P30876 (Uniprot-TrEMBL)
POLR2C [nucleoplasm]	Protein	P19387 (Uniprot-TrEMBL)
POLR2D(2-142) [nucleoplasm]	Protein	O15514 (Uniprot-TrEMBL)
POLR2E [nucleoplasm]	Protein	P19388 (Uniprot-TrEMBL)
POLR2F(1-127) [nucleoplasm]	Protein	P61218 (Uniprot-TrEMBL)
POLR2G [nucleoplasm]	Protein	P62487 (Uniprot-TrEMBL)
POLR2H [nucleoplasm]	Protein	P52434 (Uniprot-TrEMBL)
POLR2I [nucleoplasm]	Protein	P36954 (Uniprot-TrEMBL)
POLR2J [nucleoplasm]	Protein	P52435 (Uniprot-TrEMBL)
POLR2K [nucleoplasm]	Protein	P53803 (Uniprot-TrEMBL)
POLR2L [nucleoplasm]	Protein	P62875 (Uniprot-TrEMBL)
POM121 [nuclear envelope]	Protein	Q96HA1 (Uniprot-TrEMBL)
PRPF4 [nucleoplasm]	Protein	O43172 (Uniprot-TrEMBL)
PRPF6 [nucleoplasm]	Protein	O94906 (Uniprot-TrEMBL)
PRPF8 [nucleoplasm]	Protein	Q6P2Q9 (Uniprot-TrEMBL)
PTBP1 [nucleoplasm]	Protein	P26599 (Uniprot-TrEMBL)
PTBP1	Protein	P26599 (Uniprot-TrEMBL)
RAE1 [nuclear envelope]	Protein	P78406 (Uniprot-TrEMBL)
RANBP2 [cytosol]	Protein	P49792 (Uniprot-TrEMBL)
RBM5 [nucleoplasm]	Protein	P52756 (Uniprot-TrEMBL)
RBM5	Protein	P52756 (Uniprot-TrEMBL)
RBM8A [cytosol]	Protein	Q9Y5S9 (Uniprot-TrEMBL)
RBM8A [nucleoplasm]	Protein	Q9Y5S9 (Uniprot-TrEMBL)
RBMX(1-391) [nucleoplasm]	Protein	P38159 (Uniprot-TrEMBL)
RBMX(1-391)	Protein	P38159 (Uniprot-TrEMBL)
RNA polymerase II (phosphorylated):TFIIF complex	Complex	REACT_4593 (Reactome)
RNPS1 [cytosol]	Protein	Q15287 (Uniprot-TrEMBL)
RNPS1 [nucleoplasm]	Protein	Q15287 (Uniprot-TrEMBL)
RNPS1	Protein	Q15287 (Uniprot-TrEMBL)
SEH1L-2 [nuclear envelope]	Protein	Q96EE3-2 (Uniprot-TrEMBL)
SF3A1 [nucleoplasm]	Protein	Q15459 (Uniprot-TrEMBL)
SF3A2 [nucleoplasm]	Protein	Q15428 (Uniprot-TrEMBL)
SF3A3 [nucleoplasm]	Protein	Q12874 (Uniprot-TrEMBL)
SF3B1 [nucleoplasm]	Protein	O75533 (Uniprot-TrEMBL)
SF3B14 [nucleoplasm]	Protein	Q9Y3B4 (Uniprot-TrEMBL)
SF3B2 [nucleoplasm]	Protein	Q13435 (Uniprot-TrEMBL)
SF3B3 [nucleoplasm]	Protein	Q15393 (Uniprot-TrEMBL)
SF3B4 [nucleoplasm]	Protein	Q15427 (Uniprot-TrEMBL)
SF3B5 [nucleoplasm]	Protein	Q9BWJ5 (Uniprot-TrEMBL)
SLBP [cytosol]	Protein	Q14493 (Uniprot-TrEMBL)
SLBP [nucleoplasm]	Protein	Q14493 (Uniprot-TrEMBL)
SMC1A [nucleoplasm]	Protein	Q14683 (Uniprot-TrEMBL)
SMC1A	Protein	Q14683 (Uniprot-TrEMBL)
SMC2 (P-loop, DA-box)		REACT_2529 (Reactome)
SNRNP200 [nucleoplasm]	Protein	O75643 (Uniprot-TrEMBL)
SNRNP40 [nucleoplasm]	Protein	Q96DI7 (Uniprot-TrEMBL)
SNRNP70 [nucleoplasm]	Protein	P08621 (Uniprot-TrEMBL)
SNRPA [nucleoplasm]	Protein	P09012 (Uniprot-TrEMBL)
SNRPA1 [nucleoplasm]	Protein	P09661 (Uniprot-TrEMBL)
SNRPB2 [nucleoplasm]	Protein	P08579 (Uniprot-TrEMBL)
SNRPD2 [nucleoplasm]	Protein	P62316 (Uniprot-TrEMBL)
SNRPE [nucleoplasm]	Protein	P62304 (Uniprot-TrEMBL)
SNRPF [nucleoplasm]	Protein	P62306 (Uniprot-TrEMBL)
SNRPG [nucleoplasm]	Protein	P62308 (Uniprot-TrEMBL)
SRRM1 [cytosol]	Protein	Q8IYB3 (Uniprot-TrEMBL)
SRRM1 [nucleoplasm]	Protein	Q8IYB3 (Uniprot-TrEMBL)
SRRM1	Protein	Q8IYB3 (Uniprot-TrEMBL)
SRSF1 [nucleoplasm]	Protein	Q07955 (Uniprot-TrEMBL)
SRSF11 [nucleoplasm]	Protein	Q05519 (Uniprot-TrEMBL)
SRSF11	Protein	Q05519 (Uniprot-TrEMBL)
SRSF1	Protein	Q07955 (Uniprot-TrEMBL)
SRSF2 [nucleoplasm]	Protein	Q01130 (Uniprot-TrEMBL)
SRSF2	Protein	Q01130 (Uniprot-TrEMBL)
SRSF3 [nucleoplasm]	Protein	P84103 (Uniprot-TrEMBL)
SRSF3	Protein	P84103 (Uniprot-TrEMBL)
SRSF4 [nucleoplasm]	Protein	Q08170 (Uniprot-TrEMBL)
SRSF4	Protein	Q08170 (Uniprot-TrEMBL)
SRSF5 [nucleoplasm]	Protein	Q13243 (Uniprot-TrEMBL)
SRSF5	Protein	Q13243 (Uniprot-TrEMBL)
SRSF6 [nucleoplasm]	Protein	Q13247 (Uniprot-TrEMBL)
SRSF6	Protein	Q13247 (Uniprot-TrEMBL)
SRSF7 [nucleoplasm]	Protein	Q16629 (Uniprot-TrEMBL)
SRSF7	Protein	Q16629 (Uniprot-TrEMBL)
SRSF9 [nucleoplasm]	Protein	Q13242 (Uniprot-TrEMBL)
SRSF9	Protein	Q13242 (Uniprot-TrEMBL)
SUGP1 [nucleoplasm]	Protein	Q8IWZ8 (Uniprot-TrEMBL)
SUGP1	Protein	Q8IWZ8 (Uniprot-TrEMBL)
Spliceosomal Intermediate C Complex	Complex	REACT_5473 (Reactome)
Spliceosomal A Complex	Complex	REACT_4512 (Reactome)
Spliceosomal Active C Complex	Complex	REACT_2680 (Reactome)
Spliceosomal B Complex	Complex	REACT_3078 (Reactome)
Spliceosomal E Complex	Complex	REACT_4545 (Reactome)
Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex	Complex	REACT_5191 (Reactome)
TAP:3'-polyadenylated, capped mRNA complex	Complex	REACT_4136 (Reactome)
TPR [nucleoplasm]	Protein	P12270 (Uniprot-TrEMBL)
TXNL4A [nucleoplasm]	Protein	P83876 (Uniprot-TrEMBL)
U1 snRNA [nucleoplasm]	Protein	V00590 (EMBL)
U1 snRNP	Complex	REACT_2910 (Reactome)	The U1 snRNP is a particle consisting of the U1 snRNA and Sm core plus unique snRNP polypeptides. The U1-specific polypeptides are 70K, A, and C. The Sm core polypeptides are B, B', D1, D2, D3, E, F, G. The Sm core is a heteroheptamer in the shape of a donut, containing either B or B', which are almost identical to each other.
U11 snRNP	Complex	REACT_5751 (Reactome)
U12 snRNP	Complex	REACT_3595 (Reactome)
U2 snRNA [nucleoplasm]	Protein	X59360 (EMBL)
U2 snRNP	Complex	REACT_3715 (Reactome)
U2AF1 [nucleoplasm]	Protein	Q01081 (Uniprot-TrEMBL)
U2AF1	Protein	Q01081 (Uniprot-TrEMBL)
U2AF2 [nucleoplasm]	Protein	P26368 (Uniprot-TrEMBL)
U2AF2	Protein	P26368 (Uniprot-TrEMBL)
U4 ATAC snRNP	Complex	REACT_5266 (Reactome)
U4 ATAC:U5:U6 ATAC Complex	Complex	REACT_4539 (Reactome)
U4 snRNA [nucleoplasm]	Protein	X59361 (EMBL)
U4 snRNP	Complex	REACT_4877 (Reactome)
U4:U5:U6 trisnRNP complex	Complex	REACT_5066 (Reactome)
U5 snRNA [nucleoplasm]	Protein	X04293 (EMBL)
U5 snRNP	Complex	REACT_2482 (Reactome)
U6 ATAC snRNP	Complex	REACT_3135 (Reactome)
U6 snRNA [nucleoplasm]	Protein	X59362 (EMBL)
UBA, Tudor - FLJ21007		REACT_3970 (Reactome)
UPF3B [cytosol]	Protein	Q9BZI7 (Uniprot-TrEMBL)
UPF3B [nucleoplasm]	Protein	Q9BZI7 (Uniprot-TrEMBL)
UPF3B	Protein	Q9BZI7 (Uniprot-TrEMBL)
YBX1 [nucleoplasm]	Protein	P67809 (Uniprot-TrEMBL)
YBX1	Protein	P67809 (Uniprot-TrEMBL)
capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex	Complex	REACT_3243 (Reactome)
capped, methylated pre-mRNA:CBC Complex	Complex	REACT_3634 (Reactome)
capped, methylated pre-mRNP:CBC complex	Complex	REACT_2736 (Reactome)
hPrp18		REACT_3085 (Reactome)
hPrp19		REACT_3274 (Reactome)
hPrp22		REACT_3038 (Reactome)
hPrp43		REACT_5171 (Reactome)
hPrp5		REACT_3263 (Reactome)
hSLU7		REACT_5157 (Reactome)
hTra2		REACT_4242 (Reactome)
intron-containing complex	Complex	REACT_3239 (Reactome)
mRNA (N6-adenosine)-methyltransferase	Complex	REACT_3236 (Reactome)
mRNA 3'-end cleavage factor	Complex	REACT_2642 (Reactome)
p-S5-POLR2A [nucleoplasm]	Protein	P24928 (Uniprot-TrEMBL)
p68 DEAH protein		REACT_4900 (Reactome)
post exon ligation complex	Complex	REACT_5793 (Reactome)

Annotated Interactions

View all...

Source	Target	Type	Database reference	Comment
	3' end cleaved, ligated exon containing complex	Arrow	REACT_1914 (Reactome)
3' end cleaved, ligated exon containing complex			REACT_1162 (Reactome)
	3'-polyadenylated, capped mRNA complex	Arrow	REACT_1162 (Reactome)
3'-polyadenylated, capped mRNA complex			REACT_53 (Reactome)
	ALYREF	Arrow	REACT_1044 (Reactome)
	ALYREF	Arrow	REACT_1228 (Reactome)
	ALYREF	Arrow	REACT_1334 (Reactome)
	ALYREF	Arrow	REACT_1356 (Reactome)
ALYREF			REACT_1604 (Reactome)
ALYREF			REACT_1897 (Reactome)
ALYREF			REACT_222 (Reactome)
ALYREF			REACT_696 (Reactome)
ASR2B			REACT_222 (Reactome)
	ATAC A Complex	Arrow	REACT_864 (Reactome)
ATAC A Complex			REACT_1253 (Reactome)
	ATAC B Complex	Arrow	REACT_1253 (Reactome)
ATAC B Complex			REACT_1615 (Reactome)
	ATAC C Complex with lariat containing 5'-end cleaved mRNA	Arrow	REACT_2241 (Reactome)
ATAC C Complex with lariat containing 5'-end cleaved mRNA			REACT_1494 (Reactome)
	ATAC C Complex	Arrow	REACT_1615 (Reactome)
ATAC C Complex			REACT_2241 (Reactome)
ATP			REACT_1162 (Reactome)
CC1.3 protein /3 RRM, RS			REACT_222 (Reactome)
CCAR1			REACT_222 (Reactome)
CD2BP2			REACT_222 (Reactome)
	CDC40	Arrow	REACT_138 (Reactome)
CDC40			REACT_788 (Reactome)
	CF I	Arrow	REACT_1914 (Reactome)
	CF II	Arrow	REACT_1914 (Reactome)
CF II			REACT_1184 (Reactome)
CF I			REACT_1184 (Reactome)
	CPSF	Arrow	REACT_1162 (Reactome)
	CPSF	Arrow	REACT_1897 (Reactome)
CPSF			REACT_1184 (Reactome)
	Cap Binding Complex (CBC)	Arrow	REACT_1897 (Reactome)
	Cap Binding Complex (CBC)	Arrow	REACT_696 (Reactome)
	Cleavage and Polyadenylation Complex	Arrow	REACT_1184 (Reactome)
Cleavage and Polyadenylation Complex			REACT_625 (Reactome)
	CstF	Arrow	REACT_1914 (Reactome)
CstF			REACT_1184 (Reactome)
	DHX38	Arrow	REACT_138 (Reactome)
DHX38			REACT_788 (Reactome)
DHX9			REACT_222 (Reactome)
DNAJC8(2-253)			REACT_788 (Reactome)
DnaJ hom. NP_055602			REACT_222 (Reactome)
EIF4E			REACT_1044 (Reactome)
EIF4E			REACT_1228 (Reactome)
EIF4E			REACT_1334 (Reactome)
EIF4E			REACT_1356 (Reactome)
	Exon Junction Complex	Arrow	REACT_774 (Reactome)
Exon Junction Complex			REACT_1331 (Reactome)
	Export Receptor bound mature mRNA Complex	Arrow	REACT_138 (Reactome)
	Export Receptor bound mature mRNA Complex	Arrow	REACT_2104 (Reactome)
Export Receptor bound mature mRNA Complex			REACT_1228 (Reactome)
Export Receptor bound mature mRNA Complex			REACT_2104 (Reactome)
FUS			REACT_222 (Reactome)
	HNRNPA0	Arrow	REACT_1331 (Reactome)
HNRNPA0			REACT_1877 (Reactome)
	HNRNPA1	Arrow	REACT_1331 (Reactome)
HNRNPA1			REACT_1877 (Reactome)
	HNRNPA2B1	Arrow	REACT_1331 (Reactome)
HNRNPA2B1			REACT_1877 (Reactome)
	HNRNPA3	Arrow	REACT_1331 (Reactome)
HNRNPA3			REACT_1877 (Reactome)
	HNRNPC	Arrow	REACT_1331 (Reactome)
HNRNPC			REACT_1877 (Reactome)
	HNRNPD	Arrow	REACT_1331 (Reactome)
HNRNPD			REACT_1877 (Reactome)
	HNRNPF(1-415)	Arrow	REACT_1331 (Reactome)
HNRNPF(1-415)			REACT_1877 (Reactome)
	HNRNPH1(1-449)	Arrow	REACT_1331 (Reactome)
HNRNPH1(1-449)			REACT_1877 (Reactome)
	HNRNPH2	Arrow	REACT_1331 (Reactome)
HNRNPH2			REACT_1877 (Reactome)
	HNRNPK	Arrow	REACT_1331 (Reactome)
HNRNPK			REACT_1877 (Reactome)
	HNRNPL	Arrow	REACT_1331 (Reactome)
HNRNPL			REACT_1877 (Reactome)
	HNRNPM	Arrow	REACT_1331 (Reactome)
HNRNPM			REACT_1877 (Reactome)
	HNRNPR	Arrow	REACT_1331 (Reactome)
HNRNPR			REACT_1877 (Reactome)
	HNRNPU	Arrow	REACT_1331 (Reactome)
HNRNPUL1			REACT_222 (Reactome)
HNRNPU			REACT_1877 (Reactome)
HuR /3 RRM protein			REACT_222 (Reactome)
	Ligated exon containing complex	Arrow	REACT_1331 (Reactome)
Ligated exon containing complex			REACT_1914 (Reactome)
Magoh-Y14 complex			REACT_774 (Reactome)
	Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex	Arrow	REACT_904 (Reactome)
Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex			REACT_1356 (Reactome)
	Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref complex	Arrow	REACT_696 (Reactome)
Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref complex			REACT_904 (Reactome)
	Mature Intronless Transcript Derived mRNA:eIF4E Complex	Arrow	REACT_1334 (Reactome)
Mature Intronless transcript derived Histone mRNA:SLBP:CBP80:CBP20			REACT_1604 (Reactome)
	Mature SLBP independent Histone mRNA:eIF4E complex	Arrow	REACT_1356 (Reactome)
	Mature intronless derived mRNA:TAP:Aly/Ref complex	Arrow	REACT_1004 (Reactome)
Mature intronless derived mRNA:TAP:Aly/Ref complex			REACT_1334 (Reactome)
Mature intronless derived mRNA complex			REACT_1897 (Reactome)
	Mature intronless transcript derived Histone mRNA:SLBP:TAP:Aly/Ref complex	Arrow	REACT_1604 (Reactome)
	Mature intronless transcript derived Histone mRNA:SLBP:TAP:Aly/Ref complex	Arrow	REACT_1799 (Reactome)
Mature intronless transcript derived Histone mRNA:SLBP:TAP:Aly/Ref complex			REACT_1044 (Reactome)
Mature intronless transcript derived Histone mRNA:SLBP:TAP:Aly/Ref complex			REACT_1799 (Reactome)
	Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex	Arrow	REACT_1044 (Reactome)
Mature intronless transcript derived Histone pre-mRNA:CBC complex			REACT_696 (Reactome)
	Mature mRNP Complex	Arrow	REACT_1228 (Reactome)
	NCBP1	Arrow	REACT_1604 (Reactome)
	NCBP2	Arrow	REACT_1604 (Reactome)
NFAR-2 protein			REACT_222 (Reactome)
NFX.1			REACT_222 (Reactome)
	NXF1(2-619)	Arrow	REACT_1044 (Reactome)
	NXF1(2-619)	Arrow	REACT_1228 (Reactome)
	NXF1(2-619)	Arrow	REACT_1334 (Reactome)
	NXF1(2-619)	Arrow	REACT_1356 (Reactome)
NXF1(2-619)			REACT_1604 (Reactome)
NXF1(2-619)			REACT_1897 (Reactome)
NXF1(2-619)			REACT_53 (Reactome)
NXF1(2-619)			REACT_696 (Reactome)
Nuclear Pore Complex (NPC)		Arrow	REACT_1004 (Reactome)
Nuclear Pore Complex (NPC)		Arrow	REACT_1044 (Reactome)
Nuclear Pore Complex (NPC)		Arrow	REACT_1228 (Reactome)
Nuclear Pore Complex (NPC)		Arrow	REACT_1334 (Reactome)
Nuclear Pore Complex (NPC)		Arrow	REACT_1356 (Reactome)
Nuclear Pore Complex (NPC)		Arrow	REACT_138 (Reactome)
Nuclear Pore Complex (NPC)		Arrow	REACT_1604 (Reactome)
Nuclear Pore Complex (NPC)		Arrow	REACT_1799 (Reactome)
Nuclear Pore Complex (NPC)		Arrow	REACT_1897 (Reactome)
Nuclear Pore Complex (NPC)		Arrow	REACT_2104 (Reactome)
Nuclear Pore Complex (NPC)		Arrow	REACT_696 (Reactome)
Nuclear Pore Complex (NPC)		Arrow	REACT_904 (Reactome)
	Nucleoplasmic mature intronless derived mRNA:TAP:Aly/Ref complex	Arrow	REACT_1897 (Reactome)
Nucleoplasmic mature intronless derived mRNA:TAP:Aly/Ref complex			REACT_1004 (Reactome)
	PABPN1	Arrow	REACT_1162 (Reactome)
PABPN1			REACT_1184 (Reactome)
	PAPOLA(2-745)	Arrow	REACT_1162 (Reactome)
PAPOLA(2-745)			REACT_1184 (Reactome)
PAPOLA(2-745)		mim-catalysis	REACT_1162 (Reactome)
	PCBP1	Arrow	REACT_1331 (Reactome)
PCBP1			REACT_1877 (Reactome)
	PCBP2	Arrow	REACT_1331 (Reactome)
PCBP2			REACT_1877 (Reactome)
	PTBP1	Arrow	REACT_1331 (Reactome)
PTBP1			REACT_1877 (Reactome)
RBM5			REACT_222 (Reactome)
	RBMX(1-391)	Arrow	REACT_1331 (Reactome)
RBMX(1-391)			REACT_1877 (Reactome)
			REACT_1004 (Reactome)	The nucleoplasmic 3' polyadenylated, capped intronless mRNA and TAP are transported through the NPC to the cyotplasmic side of the pore.
			REACT_1044 (Reactome)	At some point eIF4E binds the mature mRNA. While TAP and Aly/Ref are released and will be reycled back to the nucleoplasm.
			REACT_1162 (Reactome)	The upstream fragment generated by 3' cleavage of the pre-mRNA receives a poly(A) tail of approximately 250 AMP residues in a reaction depending on the AAUAAA sequence 10 to 30 nucleotides upstream of the 3' end. Polyadenylation is carried out by three proteins: Poly(A) polymerase carries the catalytic activity. The enzyme has no specificity for any particular RNA sequence, and it also has a very low affinity for the RNA. Under physiological conditions, the activity of poly(A) polymerase thus depends on two auxiliary factors, both of which bind to specific RNA sequences and recruit the enzyme by a direct contact. One of these proteins is the heterotetrameric CPSF, which binds the AAUAAA sequence and is also essential for 3' cleavage. The second is the nuclear poly(A) binding protein (PABPN1), which binds the growing poly(A) tails once this has reached a length of about ten nucleotides. Stimulation of poly(A) polymerase by both proteins is synergistic and results in processive elongation of the RNA, i.e. the polymerase adds AMP residues without dissociating from the RNA. The processive reaction is terminated when the tail has reached a length of about 250 nucleotides.
			REACT_1184 (Reactome)
			REACT_1228 (Reactome)	At the beginning of this reaction, 1 molecule of 'eIF4E', and 1 molecule of 'Export Receptor bound mature mRNA Complex' are present. At the end of this reaction, 1 molecule of 'THOC4(Aly/Ref)', 1 molecule of 'Mature mRNP Complex', 1 molecule of 'SRm160', and 1 molecule of 'TAP' are present. This reaction takes place in the 'cytoplasm'.
			REACT_1253 (Reactome)	The U4atac/U6atac enters the spliceosome and U6atac snRNA forms base pairing interactions with the 5' ss and also forms base pairing interactions with U12 and U4atac is partially displaced. U5 snRNP, the only snRNP common to both the major and minor splicing pathways, also joins the spliceosome to form the B complex and interacts with nucleotides within the 3' end of the exon flanking the 5' ss.
			REACT_1331 (Reactome)	The second step of the splicing reaction results in cleavage of the transcript at the 3'splice site, and results in ligation of the two exons and excision of the intron.
			REACT_1334 (Reactome)	The cytoplasmic 3' polyadenylated, capped intronless mRNA and TAP are released from the NPC into the cytosol. Cytosolic TAP will be recycled to the nucleous, while the 3' polyadenylated, capped intronless mRNA is bound by eIF4E and destined for translation.
			REACT_1356 (Reactome)	At some point eIF4E binds the mature mRNA. While TAP and Aly/Ref are released and will be reycled back to the nucleoplasm.
			REACT_138 (Reactome)	At the beginning of this reaction, 1 molecule of 'TAP:3'-polyadenylated, capped mRNA complex' is present. At the end of this reaction, 1 molecule of 'SRp55', 1 molecule of 'U2AF 65 kDa subunit', 1 molecule of 'SR9 / SRp30', 1 molecule of 'hTra2', 1 molecule of 'hPrp16', 1 molecule of 'SR 11/ p54', 1 molecule of 'hPrp22', 1 molecule of 'SRp40', 1 molecule of 'hPrp17', 1 molecule of 'SF2/ASF/SFRS1', 1 molecule of 'hSLU7', 1 molecule of 'Export Receptor bound mature mRNA Complex', 1 molecule of 'U2AF 35 kDa subunit', 1 molecule of 'SR2 / SC35', 1 molecule of 'hPrp43', 1 molecule of 'SRp20', 1 molecule of 'SR7/ 9G8 protein', 1 molecule of 'hPrp18', and 1 molecule of 'SR4 / SRp75' are present. This reaction takes place in the 'nucleoplasm'.
			REACT_1494 (Reactome)	At the beginning of this reaction, 1 molecule of 'ATAC C Complex with lariat containing 5'-end cleaved mRNA' is present. At the end of this reaction, 1 molecule of 'U6 ATAC snRNP', 1 molecule of 'post exon ligation complex', 1 molecule of 'U12 snRNP', 1 molecule of 'U11 snRNP', and 1 molecule of 'U5 snRNP' are present. This reaction takes place in the 'nucleus'.
			REACT_1554 (Reactome)	The active C complex is formed due to a conformational change in the intermediate C complex. After formation of the active C complex, the splicing reactions occur very rapidly.
			REACT_1604 (Reactome)	Histone mRNAs are exported by a mechanism that requires TAP, the key factor requires for transport of polyadenylated mRNAs. How TAP is recruited to the histone mRNAs is not known, but it is clear that transport can occur in the absence of either the stemloop or of SLBP. The stemloop and SLBP enhance the rate of transport of histone mRNAs in Xenopus oocytes, but are not essential for transport
			REACT_1615 (Reactome)	At the beginning of this reaction, 1 molecule of 'ATAC B Complex' is present. At the end of this reaction, 1 molecule of 'U4 ATAC snRNP', and 1 molecule of 'ATAC C Complex' are present. This reaction takes place in the 'nucleus'.
			REACT_1720 (Reactome)	In addition to the methylation of the 5'-cap, there is methylation of internal nucleotides in the mRNA. This methylation can occur in translated and untranslated regions. One to three methyl groups have been seen per mRNA molecule, but methylation is non-stoichiometric. The most frequent methylation observed is at the N6 position of adenosine. The function of mRNA internal methylation, if any, is unknown.
			REACT_1799 (Reactome)	Once the transport complex is fully assembled the mature mRNA can be translocated from the nucleoplasm to the cytoplasm. The assembled complex starts at the nucleoplasmic basket, travels through the pore, and ends it journey at the cytoplasmic face of the nuclear pore complex.
			REACT_1877 (Reactome)	After the nascent pre-mRNA undergoes the initial capping and methylation reactions, it gets associated with numerous factors, including the various heterogeneous nuclear ribonucleoproteins (hnRNPS), the nuclear Cap-Binding Complex, and many splicing factors that make the pre-mRNA a substrate for splicing, 3'-end processing, and in some cases editing.
			REACT_1897 (Reactome)	The polyadenylated, capped transcript and TAP dock at the nucleoplasmic side of the NPC. The Cap Binding Complex (CBC) and CPSF complexes are released back into the nucleoplasm.
			REACT_1914 (Reactome)	Endonucleolytic cleavage separates the pre-mRNA into an upstream fragment destined to become the mature mRNA, and a downstream fragment that is rapidly degraded. Cleavage depends on two signals in the RNA, a highly conserved hexanucleotide, AAUAAA, 10 to 30 nucleotides upstream of the cleavage site, and a poorly conserved GU- or U-rich downstream element. Additional sequences, often upstream of AAUAAA, can enhance the efficiency of the reaction. Cleavage occurs most often after a CA dinucleotide. A single gene can have more than one 3' processing site. Cleavage is preceded by the assembly of a large processing complex, the composition of which is poorly defined. ATP, but not its hydrolysis, is required for assembly. Cleavage at the 3'-end of mRNAs depends on a number of protein factors. CPSF, a heterotetramer, binds specifically to the AAUAAA sequence. The heterotrimer CstF binds the downstream element. CF I, which appears to be composed of two subunits, one of several related larger polypeptides and a common smaller one, also binds RNA, but with unknown specificity. RNA recognition by these proteins is cooperative. Cleavage also requires CF II, composed of at least two subunits, and poly(A) polymerase, the enzyme synthesizing the poly(A) tail in the second step of the reaction. The polypeptide catalyzing the hydrolysis of the phosphodiester bond remains to be identified. Cleavage produces a 3'-OH on the upstream fragment and a 5'-phosphate on the downstream fragment. At some unknown point after cleavage, the downstream RNA fragment, CstF, CF I and CF II are thought to be released, whereas CPSF and poly(A) polymerase remain to carry out polyadenylation.
			REACT_1935 (Reactome)	In the first catalytic step of mRNA splicing, the 2' OH group of the bulged A at the branch site performs a nucleophilic attack on the 5' splice site phosphodiester bond, resulting in cleavage of the bond between the 5' exon and the 5' end of the intron, and formation of a new bond between the 5' end of the intron and the branch site A. This results in a lariat-shaped intermediate, with the intron still attached to the 3' exon. The branch site A has a 2'-5' phosphodiester bond with the G at the beginning of the intron, in addition to the usual 5'-3' and 3'-5'phosphodiester bonds.
			REACT_2104 (Reactome)	In this reaction, 1 molecule of 'Export Receptor bound mature mRNA Complex' is translocated from nucleoplasm to cytosol. This reaction takes place in the 'nuclear envelope'.
			REACT_222 (Reactome)	Pre-mRNA transcripts become rapidly associated with many RNA-binding proteins, including hnRNP proteins, cap-binding proteins, SR proteins, etc; in the test tube this binding does not require splice sites or ATP. The E complex, or early complex, is the first detectable functional intermediate in spliceosome assembly in vitro. It is an ATP-independent complex. When a functional 5' splice site is present, it is bound by the U1 snRNP. The splicing factor U2AF (65 and 35 kDa subunits) binds to the polypyrimidine tract (Y)n and the AG dinucleotide at the 3' splice site, respectively. SF1/mBBP binds to the branch site. Binding of many of these factors is cooperative; e.g., SR proteins and U2AF apparently interact with each other, facilitating their binding to the pre-mRNA. In the presence of ATP, the E complex is converted to the first ATP-dependent spliceosomal complex, namely the A complex.
			REACT_2241 (Reactome)	At the beginning of this reaction, 1 molecule of 'ATAC C Complex' is present. At the end of this reaction, 1 molecule of 'ATAC C Complex with lariat containing 5'-end cleaved mRNA' is present. This reaction takes place in the 'nucleus'.
			REACT_48 (Reactome)	The formation of the B complex is ATP-dependent, and both the 5' and 3' splice sites are essential for B complex assembly. The U4 and U6 snRNPS are extensively base-paired, and this U4:U6 complex associates with the U5 snRNP to form a tri-snRNP particle. This tri-snRNP particle then binds to the spliceosomal A complex, to form the spliceosomal B complex.
			REACT_53 (Reactome)	Aly/Ref recruits TAP to the Exon Junction Complex. This makes the mRNP complex ready for export to the cytoplasm.
			REACT_625 (Reactome)	The spliceosomal C complex is a very short-lived intermediate; the splicing intermediates are rapidly converted to splicing products. Also, the spliced products are released very rapidly, and no complex containing both the splicing products has been isolated. Conversion of the spliceosomal B complex to the spliceosomal C complex requires ATP. The extensive base-pairing between the U4 and U6 snRNAs is disrupted during the formation of the C complex, which is thought to require helicase-type activity associated with the DEAD box factors.
			REACT_696 (Reactome)	Histone mRNAs are exported by a mechanism that requires TAP, the key factor requires for transport of polyadenylated mRNAs. How TAP is recruited to the histone mRNAs is not known, but it is clear that transport can occur in the absence of either the stemloop or of SLBP. The mature transcript docks at the NPC, in the course of transport CBC will be lost from the mRNA cap, and remain in the nucleous.
			REACT_774 (Reactome)	At the beginning of this reaction, 1 molecule of 'Magoh-Y14 complex', and 1 molecule of 'Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex' are present. At the end of this reaction, 1 molecule of 'Exon Junction Complex' is present. This reaction takes place in the 'nucleoplasm'.
			REACT_788 (Reactome)	The A complex is the first ATP-dependent complex in spliceosome assembly. U2AF recruits the U2 snRNP to bind to the branch site in the E complex in an ATP-dependent fashion, to form the A complex. The U2 snRNA base-pairs with the branch site, causing the branch-site adenosine to bulge out, which later positions it for nucleophilic attack at the 5' splice site. The A complex serves as a substrate for formation of the B complex.
			REACT_864 (Reactome)	U12-type AT-AC introns are distinguished from the major U2-type introns by the consensus sequences of their highly conserved splicing signals. U12 introns have the 5' ss consensus sequence (G/A)TATCCTTT, the branchpoint sequence TTTCCTTAACT and the 3' ss (C/T)AG. Initial recognition of AT-AC introns involves interaction of U12 snRNP with the branch-point sequence and U11 with the 5' ss. Unlike the major splicing pathway, U11 and U12 are in a complex and interact with the pre-mRNA simultaneously, binding in an ATP-dependent manner as a di-snRNP complex and likely bridging the 5' ss and 3' ss region. Twenty proteins have been identified in the U11/U12 di-snRNP complex including the snRNP Sm proteins B’, B, D3, D2, D1, E, F, and G which are identical to the major splicing pathway Sm proteins. A U2 snRNP core protein complex, SF3b is also found in the U11/U12 di-snRNP, including p14, a protein that interacts with the branchpoint adenosine. SR proteins are required for formation of A complex in AT-AC splicing. The same SR proteins involved in splicing of the major introns are also active in splicing of AT-AC introns, though, as in the major pathway, there is substrate specificity.
			REACT_904 (Reactome)	The mature SLBP independent intronless histone mRNA is transported through the nucler pore to the cytoplasmic side.
	RNA polymerase II (phosphorylated):TFIIF complex	Arrow	REACT_1331 (Reactome)
RNPS1			REACT_222 (Reactome)
SMC1A			REACT_222 (Reactome)
SMC2 (P-loop, DA-box)			REACT_222 (Reactome)
	SRRM1	Arrow	REACT_1228 (Reactome)
SRRM1			REACT_222 (Reactome)
	SRSF11	Arrow	REACT_138 (Reactome)
SRSF11			REACT_788 (Reactome)
	SRSF1	Arrow	REACT_138 (Reactome)
SRSF1			REACT_222 (Reactome)
SRSF1			REACT_864 (Reactome)
	SRSF2	Arrow	REACT_138 (Reactome)
SRSF2			REACT_222 (Reactome)
SRSF2			REACT_864 (Reactome)
	SRSF3	Arrow	REACT_138 (Reactome)
SRSF3			REACT_222 (Reactome)
	SRSF4	Arrow	REACT_138 (Reactome)
SRSF4			REACT_788 (Reactome)
	SRSF5	Arrow	REACT_138 (Reactome)
SRSF5			REACT_222 (Reactome)
	SRSF6	Arrow	REACT_138 (Reactome)
SRSF6			REACT_222 (Reactome)
SRSF6			REACT_864 (Reactome)
	SRSF7	Arrow	REACT_138 (Reactome)
SRSF7			REACT_222 (Reactome)
SRSF7			REACT_864 (Reactome)
	SRSF9	Arrow	REACT_138 (Reactome)
SRSF9			REACT_222 (Reactome)
SUGP1			REACT_222 (Reactome)
	Spliceosomal Intermediate C Complex	Arrow	REACT_625 (Reactome)
Spliceosomal Intermediate C Complex			REACT_1554 (Reactome)
	Spliceosomal A Complex	Arrow	REACT_788 (Reactome)
Spliceosomal A Complex			REACT_48 (Reactome)
	Spliceosomal Active C Complex	Arrow	REACT_1554 (Reactome)
Spliceosomal Active C Complex			REACT_1935 (Reactome)
	Spliceosomal B Complex	Arrow	REACT_48 (Reactome)
Spliceosomal B Complex			REACT_625 (Reactome)
	Spliceosomal E Complex	Arrow	REACT_222 (Reactome)
Spliceosomal E Complex			REACT_788 (Reactome)
	Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex	Arrow	REACT_1935 (Reactome)
Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex			REACT_774 (Reactome)
	TAP:3'-polyadenylated, capped mRNA complex	Arrow	REACT_53 (Reactome)
TAP:3'-polyadenylated, capped mRNA complex			REACT_138 (Reactome)
	U1 snRNP	Arrow	REACT_625 (Reactome)
U1 snRNP			REACT_222 (Reactome)
	U11 snRNP	Arrow	REACT_1494 (Reactome)
U11 snRNP			REACT_864 (Reactome)
	U12 snRNP	Arrow	REACT_1494 (Reactome)
U12 snRNP			REACT_864 (Reactome)
U2 snRNP			REACT_788 (Reactome)
	U2AF1	Arrow	REACT_138 (Reactome)
U2AF1			REACT_222 (Reactome)
	U2AF2	Arrow	REACT_138 (Reactome)
U2AF2			REACT_222 (Reactome)
	U4 ATAC snRNP	Arrow	REACT_1615 (Reactome)
U4 ATAC:U5:U6 ATAC Complex			REACT_1253 (Reactome)
	U4 snRNP	Arrow	REACT_625 (Reactome)
U4:U5:U6 trisnRNP complex			REACT_48 (Reactome)
	U5 snRNP	Arrow	REACT_1494 (Reactome)
	U6 ATAC snRNP	Arrow	REACT_1494 (Reactome)
UBA, Tudor - FLJ21007			REACT_222 (Reactome)
UPF3B			REACT_1935 (Reactome)
YBX1			REACT_222 (Reactome)
capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex			REACT_1720 (Reactome)
	capped, methylated pre-mRNA:CBC Complex	Arrow	REACT_1720 (Reactome)
capped, methylated pre-mRNA:CBC Complex			REACT_1877 (Reactome)
capped, methylated pre-mRNA:CBC Complex			REACT_864 (Reactome)
	capped, methylated pre-mRNP:CBC complex	Arrow	REACT_1877 (Reactome)
capped, methylated pre-mRNP:CBC complex			REACT_222 (Reactome)
	hPrp18	Arrow	REACT_138 (Reactome)
hPrp19			REACT_222 (Reactome)
	hPrp22	Arrow	REACT_138 (Reactome)
	hPrp43	Arrow	REACT_138 (Reactome)
hPrp5			REACT_788 (Reactome)
	hSLU7	Arrow	REACT_138 (Reactome)
	hTra2	Arrow	REACT_138 (Reactome)
hTra2			REACT_788 (Reactome)
	intron-containing complex	Arrow	REACT_1331 (Reactome)
mRNA (N6-adenosine)-methyltransferase		mim-catalysis	REACT_1720 (Reactome)
mRNA 3'-end cleavage factor		mim-catalysis	REACT_1914 (Reactome)
p68 DEAH protein			REACT_222 (Reactome)
	post exon ligation complex	Arrow	REACT_1494 (Reactome)