Host Interactions of HIV factors (Homo sapiens)
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Description
Like all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewise requires evasion of APOBEC3G-mediated mutagenesis of reverse transcripts, a process mediated by the viral Vif protein.Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=162909
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History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| Protein | |||
| 26S proteasome | Complex | REACT_2353 (Reactome)  | |
| AAAS [nuclear envelope] | Protein | Q9NRG9 (Uniprot-TrEMBL) | |
| ADP/ATP translocase monomer (generic) | Protein | REACT_8605 (Reactome) | |
| ANT1:Vpr complex | Complex | REACT_8897 (Reactome) | |
| AP-1 Complex | Complex | REACT_11249 (Reactome) | |
| AP-2 Complex | Complex | REACT_11732 (Reactome) | |
| AP1B1 [cytosol] | Protein | Q10567 (Uniprot-TrEMBL) | |
| AP1G1 [cytosol] | Protein | O43747 (Uniprot-TrEMBL) | |
| AP1M1 [cytosol] | Protein | Q9BXS5 (Uniprot-TrEMBL) | |
| AP1M2(2-423) [cytosol] | Protein | Q9Y6Q5 (Uniprot-TrEMBL) | |
| AP1S1 [cytosol] | Protein | P61966 (Uniprot-TrEMBL) | |
| AP1S2 [cytosol] | Protein | P56377 (Uniprot-TrEMBL) | |
| AP1S3 [cytosol] | Protein | Q96PC3 (Uniprot-TrEMBL) | |
| AP2A1 [cytosol] | Protein | O95782 (Uniprot-TrEMBL) | |
| AP2A2(1-939) [cytosol] | Protein | O94973 (Uniprot-TrEMBL) | |
| AP2B1 [cytosol] | Protein | P63010 (Uniprot-TrEMBL) | |
| AP2M1 [cytosol] | Protein | Q96CW1 (Uniprot-TrEMBL) | |
| AP2M1 [plasma membrane] | Protein | Q96CW1 (Uniprot-TrEMBL) | |
| AP2M1 | Protein | Q96CW1 (Uniprot-TrEMBL) | |
| AP2S1 [cytosol] | Protein | P53680 (Uniprot-TrEMBL) | |
| APOBEC3G-3 [cytosol] | Protein | Q9HC16-3 (Uniprot-TrEMBL) | |
| APOBEC3G:HIV-1PIC | Complex | REACT_9691 (Reactome) | |
| APOBEC3G:RTC with
deaminated minus sssDNA:tRNA primer:RNA template | Complex | REACT_9785 (Reactome) | |
| APOBEC3G:RTC with
minus sssDNA:tRNA primer:RNA template | Complex | REACT_9745 (Reactome) | |
| APOBEC3G:Vif:Cul5:SCF complex | Complex | REACT_9643 (Reactome) | |
| APOBEC3G | Protein | REACT_9891 (Reactome) | |
| ARF1(2-181) [cytosol] | Protein | P84077 (Uniprot-TrEMBL) | |
| ARF1(2-181) | Protein | P84077 (Uniprot-TrEMBL) | |
| ATP6V1H [cytosol] | Protein | Q9UI12 (Uniprot-TrEMBL) | |
| ATP6V1H [plasma membrane] | Protein | Q9UI12 (Uniprot-TrEMBL) | |
| ATP6V1H | Protein | Q9UI12 (Uniprot-TrEMBL) | |
| Arf1:Nef:endosomal CD4 | Complex | REACT_11580 (Reactome) | |
| B2M(21-119) [Golgi membrane] | Protein | P61769 (Uniprot-TrEMBL) | |
| B2M(21-119) [early endosome membrane] | Protein | P61769 (Uniprot-TrEMBL) | |
| BANF1 [cytosol] | Protein | O75531 (Uniprot-TrEMBL) | |
| BTRC [cytosol] | Protein | Q9Y297 (Uniprot-TrEMBL) | |
| BTRC | Protein | Q9Y297 (Uniprot-TrEMBL) | |
| CCNT1 [nucleoplasm] | Protein | O60563 (Uniprot-TrEMBL) | |
| CD247-1 [plasma membrane] | Protein | P20963-1 (Uniprot-TrEMBL) | |
| CD247-1 | Protein | P20963-1 (Uniprot-TrEMBL) | |
| CD28 [cytosol] | Protein | P10747 (Uniprot-TrEMBL) | |
| CD28 [plasma membrane] | Protein | P10747 (Uniprot-TrEMBL) | |
| CD28:Nef:Clathrin-coated
Pit Adapter Protein Complex | Complex | REACT_11677 (Reactome) | |
| CD28:Nef:Clathrin-coated Pit Adapter Protein | Complex | REACT_11442 (Reactome) | |
| CD28 | Protein | P10747 (Uniprot-TrEMBL) | |
| CD4 [early endosome] | Protein | P01730 (Uniprot-TrEMBL) | |
| CD4 [endoplasmic reticulum membrane] | Protein | P01730 (Uniprot-TrEMBL) | |
| CD4 [plasma membrane] | Protein | P01730 (Uniprot-TrEMBL) | |
| CD4:Lck Complex | Complex | REACT_11737 (Reactome) | |
| CD4:Nef Complex | Complex | REACT_11987 (Reactome) | |
| CD4:Nef:AP-2
Complex:v-ATPase Complex | Complex | REACT_11339 (Reactome) | |
| CD4:Vpu complex | Complex | REACT_9255 (Reactome) | |
| CD4:Vpu:beta-TrCP_1:Skp1 complex | Complex | REACT_9120 (Reactome) | |
| CD4:Vpu:beta-TrCP_1 | Complex | REACT_9238 (Reactome) | |
| CD4 | Protein | P01730 (Uniprot-TrEMBL) | |
| CD8:Nef Complex | Complex | REACT_11411 (Reactome) | |
| CD8:Nef:AP-2
Complex:v-ATPase Complex | Complex | REACT_11369 (Reactome) | |
| CD8B [early endosome membrane] | Protein | P10966 (Uniprot-TrEMBL) | |
| CD8B [plasma membrane] | Protein | P10966 (Uniprot-TrEMBL) | |
| CDK9 [nucleoplasm] | Protein | P50750 (Uniprot-TrEMBL) | |
| CUL5 [cytosol] | Protein | Q93034 (Uniprot-TrEMBL) | |
| Cul5-SCF complex | Complex | REACT_9690 (Reactome) | |
| DOCK2 [cytosol] | Protein | Q92608 (Uniprot-TrEMBL) | |
| DOCK2:ELMO1:RAC1:Nef Complex | Complex | REACT_11827 (Reactome) | |
| DOCK2 | Protein | Q92608 (Uniprot-TrEMBL) | |
| ELMO1 [cytosol] | Protein | Q92556 (Uniprot-TrEMBL) | |
| ELMO1 | Protein | Q92556 (Uniprot-TrEMBL) | |
| FYN(2-537) [cytosol] | Protein | P06241 (Uniprot-TrEMBL) | |
| FYN(2-537) | Protein | P06241 (Uniprot-TrEMBL) | |
| Fyn:Nef Complex | Complex | REACT_11637 (Reactome) | |
| GDP [cytosol] | Metabolite | CHEBI:17552 (ChEBI) | |
| GDP [nucleoplasm] | Metabolite | CHEBI:17552 (ChEBI) | |
| GDP | Metabolite | CHEBI:17552 (ChEBI) | |
| GTP [cytosol] | Metabolite | CHEBI:15996 (ChEBI) | |
| GTP [nucleoplasm] | Metabolite | CHEBI:15996 (ChEBI) | |
| GTP | Metabolite | CHEBI:15996 (ChEBI) | |
| H2O | Metabolite | CHEBI:15377 (ChEBI) | |
| HCK(2-526) [cytosol] | Protein | P08631 (Uniprot-TrEMBL) | |
| HCK(2-526) | Protein | P08631 (Uniprot-TrEMBL) | |
| HIV-1 RNA template [cytosol] | Protein | AF033819 (EMBL) | |
| HIV-1 mRNA [nucleoplasm] | Protein | AF033819 (EMBL) | |
| HIV-1 mRNA [cytosol] | Protein | AF033819 (EMBL) | |
| HIV-1 mRNA | Rna | AF033819 (EMBL) | |
| HIV-1 unspliced RNA | Rna | AF033819 (EMBL) | |
| HLA class I
histocompatibility antigen, A-2 alpha chain [Golgi membrane] | Protein | P01892 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, A-2 alpha chain [early endosome membrane] | Protein | P01892 (Uniprot-TrEMBL) | |
| HMGA1 [cytosol] | Protein | P17096 (Uniprot-TrEMBL) | |
| Hck-1:Nef | Complex | REACT_11973 (Reactome) | |
| IN (Integrase)
(P04585) protein [cytosol] | Protein | P04585 (Uniprot-TrEMBL) | |
| IN bound to sticky
3' ends of viral DNA in PIC | Complex | REACT_8354 (Reactome) | |
| Importin beta-1:Rev multimer complex | Complex | REACT_9841 (Reactome) | |
| Importin-beta:Ran GTP complex | Complex | REACT_9883 (Reactome) | |
| Internalized
CD4:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase | Complex | REACT_11967 (Reactome) | |
| Internalized
CD8:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase | Complex | REACT_11305 (Reactome) | |
| KPNA1 [cytosol] | Protein | P52294 (Uniprot-TrEMBL) | |
| KPNA1 | Protein | P52294 (Uniprot-TrEMBL) | |
| KPNB1 [cytosol] | Protein | Q14974 (Uniprot-TrEMBL) | |
| KPNB1 [nucleoplasm] | Protein | Q14974 (Uniprot-TrEMBL) | |
| KPNB1 | Protein | Q14974 (Uniprot-TrEMBL) | |
| LCK [cytosol] | Protein | P06239 (Uniprot-TrEMBL) | |
| LCK | Protein | P06239 (Uniprot-TrEMBL) | |
| Lck:Nef | Complex | REACT_11930 (Reactome) | |
| Lipid Raft | REACT_11624 (Reactome) | ||
| MA (P04585) protein [cytosol] | Protein | P04585 (Uniprot-TrEMBL) | |
| MA (P04591) protein [cytosol] | Protein | P04591 (Uniprot-TrEMBL) | |
| NH3 | Metabolite | CHEBI:16134 (ChEBI) | |
| NPM1 [cytosol] | Protein | P06748 (Uniprot-TrEMBL) | |
| NPM1 [nucleoplasm] | Protein | P06748 (Uniprot-TrEMBL) | |
| NPM1 | Protein | P06748 (Uniprot-TrEMBL) | |
| NUP107 [nuclear envelope] | Protein | P57740 (Uniprot-TrEMBL) | |
| NUP133 [nuclear envelope] | Protein | Q8WUM0 (Uniprot-TrEMBL) | |
| NUP153 [nucleoplasm] | Protein | P49790 (Uniprot-TrEMBL) | |
| NUP155 [nuclear envelope] | Protein | O75694 (Uniprot-TrEMBL) | |
| NUP160 [nuclear envelope] | Protein | Q12769 (Uniprot-TrEMBL) | |
| NUP188(2-1749) [nuclear envelope] | Protein | Q5SRE5 (Uniprot-TrEMBL) | |
| NUP205(2-2012) [nuclear envelope] | Protein | Q92621 (Uniprot-TrEMBL) | |
| NUP210 [nuclear envelope] | Protein | Q8TEM1 (Uniprot-TrEMBL) | |
| NUP214 [cytosol] | Protein | P35658 (Uniprot-TrEMBL) | |
| NUP35 [nuclear envelope] | Protein | Q8NFH5 (Uniprot-TrEMBL) | |
| NUP37 [nuclear envelope] | Protein | Q8NFH4 (Uniprot-TrEMBL) | |
| NUP43 [nuclear envelope] | Protein | Q8NFH3 (Uniprot-TrEMBL) | |
| NUP50 [nucleoplasm] | Protein | Q9UKX7 (Uniprot-TrEMBL) | |
| NUP54 [nuclear envelope] | Protein | Q7Z3B4 (Uniprot-TrEMBL) | |
| NUP62 [nuclear envelope] | Protein | P37198 (Uniprot-TrEMBL) | |
| NUP85 [nuclear envelope] | Protein | Q9BW27 (Uniprot-TrEMBL) | |
| NUP88 [cytosol] | Protein | Q99567 (Uniprot-TrEMBL) | |
| NUP93 [nuclear envelope] | Protein | Q8N1F7 (Uniprot-TrEMBL) | |
| NUP98-5 [nuclear envelope] | Protein | P52948-5 (Uniprot-TrEMBL) | |
| NUPL1-2 [nuclear envelope] | Protein | Q9BVL2-1 (Uniprot-TrEMBL) | |
| NUPL2 [cytosol] | Protein | O15504 (Uniprot-TrEMBL) | |
| Nef:CD28 Complex | Complex | REACT_11853 (Reactome) | |
| Nef:T cell Receptor
zeta:Lipid Raft: Pak 2 Complex | Complex | REACT_11396 (Reactome) | |
| Nef:class I MHC
complex:AP-1:PACS-1 Complex | Complex | REACT_11657 (Reactome) | |
| Nef:class I MHC
complex:Ap-1:PACS-1 Complex | Complex | REACT_11308 (Reactome) | |
| Nef:class I MHC complex | Complex | REACT_11813 (Reactome) | |
| Nuclear Pore Complex (NPC) | Complex | REACT_5542 (Reactome) | |
| Nup45 [nuclear envelope] | Protein | Q9BVL2-2 (Uniprot-TrEMBL) | |
| P-TEFb(Cyclin T1:Cdk9) complex | Complex | REACT_6577 (Reactome) | |
| PACS1(2-963) [cytosol] | Protein | Q6VY07 (Uniprot-TrEMBL) | |
| PACS1(2-963) | Protein | Q6VY07 (Uniprot-TrEMBL) | |
| PAK2(1-524) [plasma membrane] | Protein | Q13177 (Uniprot-TrEMBL) | |
| PAK2(1-524) | Protein | Q13177 (Uniprot-TrEMBL) | |
| PIC anchored to the NPC | Complex | REACT_8912 (Reactome) | |
| POM121 [nuclear envelope] | Protein | Q96HA1 (Uniprot-TrEMBL) | |
| PPIA [cytosol] | Protein | P62937 (Uniprot-TrEMBL) | |
| PSIP1 [cytosol] | Protein | O75475 (Uniprot-TrEMBL) | |
| PSMA1 [cytosol] | Protein | P25786 (Uniprot-TrEMBL) | |
| PSMA2 [cytosol] | Protein | P25787 (Uniprot-TrEMBL) | |
| PSMA3 [cytosol] | Protein | P25788 (Uniprot-TrEMBL) | |
| PSMA4 [cytosol] | Protein | P25789 (Uniprot-TrEMBL) | |
| PSMA5 [cytosol] | Protein | P28066 (Uniprot-TrEMBL) | |
| PSMA6 [cytosol] | Protein | P60900 (Uniprot-TrEMBL) | |
| PSMA7(2-248) [cytosol] | Protein | O14818 (Uniprot-TrEMBL) | |
| PSMA8 [cytosol] | Protein | Q8TAA3 (Uniprot-TrEMBL) | |
| PSMB1 [cytosol] | Protein | P20618 (Uniprot-TrEMBL) | |
| PSMB10 [cytosol] | Protein | P40306 (Uniprot-TrEMBL) | |
| PSMB11 [cytosol] | Protein | A5LHX3 (Uniprot-TrEMBL) | |
| PSMB2 [cytosol] | Protein | P49721 (Uniprot-TrEMBL) | |
| PSMB3 [cytosol] | Protein | P49720 (Uniprot-TrEMBL) | |
| PSMB4 [cytosol] | Protein | P28070 (Uniprot-TrEMBL) | |
| PSMB5 [cytosol] | Protein | P28074 (Uniprot-TrEMBL) | |
| PSMB6 [cytosol] | Protein | P28072 (Uniprot-TrEMBL) | |
| PSMB7 [cytosol] | Protein | Q99436 (Uniprot-TrEMBL) | |
| PSMB8 [cytosol] | Protein | P28062 (Uniprot-TrEMBL) | |
| PSMB9 [cytosol] | Protein | P28065 (Uniprot-TrEMBL) | |
| PSMC1(2-440) [cytosol] | Protein | P62191 (Uniprot-TrEMBL) | |
| PSMC2 [cytosol] | Protein | P35998 (Uniprot-TrEMBL) | |
| PSMC3 [cytosol] | Protein | P17980 (Uniprot-TrEMBL) | |
| PSMC4 [cytosol] | Protein | P43686 (Uniprot-TrEMBL) | |
| PSMC5 [cytosol] | Protein | P62195 (Uniprot-TrEMBL) | |
| PSMC6(2-389) [cytosol] | Protein | P62333 (Uniprot-TrEMBL) | |
| PSMD1 [cytosol] | Protein | Q99460 (Uniprot-TrEMBL) | |
| PSMD10 [cytosol] | Protein | O75832 (Uniprot-TrEMBL) | |
| PSMD11 [cytosol] | Protein | O00231 (Uniprot-TrEMBL) | |
| PSMD12 [cytosol] | Protein | O00232 (Uniprot-TrEMBL) | |
| PSMD13 [cytosol] | Protein | Q9UNM6 (Uniprot-TrEMBL) | |
| PSMD14 [cytosol] | Protein | O00487 (Uniprot-TrEMBL) | |
| PSMD2 [cytosol] | Protein | Q13200 (Uniprot-TrEMBL) | |
| PSMD3 [cytosol] | Protein | O43242 (Uniprot-TrEMBL) | |
| PSMD4(2-377) [cytosol] | Protein | P55036 (Uniprot-TrEMBL) | |
| PSMD5 [cytosol] | Protein | Q16401 (Uniprot-TrEMBL) | |
| PSMD6(2-389) [cytosol] | Protein | Q15008 (Uniprot-TrEMBL) | |
| PSMD7(2-324) [cytosol] | Protein | P51665 (Uniprot-TrEMBL) | |
| PSMD8 [cytosol] | Protein | P48556 (Uniprot-TrEMBL) | |
| PSMD9 [cytosol] | Protein | O00233 (Uniprot-TrEMBL) | |
| PSME1 [cytosol] | Protein | Q06323 (Uniprot-TrEMBL) | |
| PSME2 [cytosol] | Protein | Q9UL46 (Uniprot-TrEMBL) | |
| PSME3 [cytosol] | Protein | P61289 (Uniprot-TrEMBL) | |
| PSME4 [cytosol] | Protein | Q14997 (Uniprot-TrEMBL) | |
| PSMF1(2-271) [cytosol] | Protein | Q92530 (Uniprot-TrEMBL) | |
| Pi | Metabolite | CHEBI:18367 (ChEBI) | |
| RAC1-1 [cytosol] | Protein | P63000-1 (Uniprot-TrEMBL) | |
| RAC1-1 | Protein | P63000-1 (Uniprot-TrEMBL) | |
| RAE1 [nuclear envelope] | Protein | P78406 (Uniprot-TrEMBL) | |
| RAN [cytosol] | Protein | P62826 (Uniprot-TrEMBL) | |
| RAN [nucleoplasm] | Protein | P62826 (Uniprot-TrEMBL) | |
| RANBP1(2-201) [nuclear envelope] | Protein | P43487 (Uniprot-TrEMBL) | |
| RANBP1(2-201) | Protein | P43487 (Uniprot-TrEMBL) | |
| RANBP2 [cytosol] | Protein | P49792 (Uniprot-TrEMBL) | |
| RANGAP1 | Protein | P46060 (Uniprot-TrEMBL) | |
| RBX1 [cytosol] | Protein | P62877 (Uniprot-TrEMBL) | |
| RCC1 | Protein | P18754 (Uniprot-TrEMBL) | |
| REV (P04618) protein [cytosol] | Protein | P04618 (Uniprot-TrEMBL) | |
| REV (P04618) protein [nucleoplasm] | Protein | P04618 (Uniprot-TrEMBL) | |
| REV (P04618) protein | Protein | P04618 (Uniprot-TrEMBL) | |
| RPS27A(1-76) [cytosol] | Protein | P62979 (Uniprot-TrEMBL) | |
| RTC with minus
sssDNA:tRNA primer:RNA template | Complex | REACT_9297 (Reactome) | |
| Ran GTPase:GDP | Complex | REACT_6416 (Reactome) | |
| Ran-GDP | Complex | REACT_9732 (Reactome) | |
| Ran-GTP | Complex | REACT_8980 (Reactome) | |
| Ran:GTP | Complex | REACT_8632 (Reactome) | |
| RanBP1:Ran-GTP:CRM1:Rev-bound mRNA complex | Complex | REACT_8366 (Reactome) | |
| Rev multimer-bound
HIV-1 mRNA:Crm1:Ran:GTP:NPC | Complex | REACT_6537 (Reactome) | |
| Rev multimer-bound
HIV-1 mRNA:Crm1:Ran:GTP | Complex | REACT_6428 (Reactome) | |
| Rev multimer-bound
HIV-1 mRNA:Crm1:Ran:GTP | Complex | REACT_6601 (Reactome) | |
| Rev multimer-bound
HIV-1 mRNA:CRM1 complex | Complex | REACT_8117 (Reactome) | |
| Rev multimer-bound HIV-1 mRNA | Complex | REACT_6517 (Reactome) | |
| Rev-bound HIV-1 mRNA | Complex | REACT_6419 (Reactome) | |
| Rev-multimer | REACT_6379 (Reactome) | ||
| Rev-multimer | REACT_6511 (Reactome) | ||
| Rev:Importin-beta:B23 | Complex | REACT_9742 (Reactome) | |
| Rev:Importin-beta:NPM1 | Complex | REACT_9868 (Reactome) | |
| Rev:importin-beta:B23:Ran-GTP complex | Complex | REACT_9842 (Reactome) | |
| Reverse
transcriptase/ribonuclease H [cytosol] | Protein | P04585 (Uniprot-TrEMBL) | |
| SEH1L-2 [nuclear envelope] | Protein | Q96EE3-2 (Uniprot-TrEMBL) | |
| SKP1 [cytosol] | Protein | P63208 (Uniprot-TrEMBL) | |
| SKP1 | Protein | P63208 (Uniprot-TrEMBL) | |
| SLC25A4
[mitochondrial inner membrane] | Protein | P12235 (Uniprot-TrEMBL) | |
| SLC25A5
[mitochondrial inner membrane] | Protein | P05141 (Uniprot-TrEMBL) | |
| SLC25A6
[mitochondrial inner membrane] | Protein | P12236 (Uniprot-TrEMBL) | |
| TCEB1 [cytosol] | Protein | Q15369 (Uniprot-TrEMBL) | |
| TCEB2 [cytosol] | Protein | Q15370 (Uniprot-TrEMBL) | |
| TPR [nucleoplasm] | Protein | P12270 (Uniprot-TrEMBL) | |
| Tat (P04608) [nucleoplasm] | Protein | P04608 (Uniprot-TrEMBL) | |
| Tat (P04608) | Protein | P04608 (Uniprot-TrEMBL) | |
| Tat:P-TEFb(Cyclin T1:Cdk9) complex | Complex | REACT_6496 (Reactome) | |
| UBA52(1-76) [cytosol] | Protein | P62987 (Uniprot-TrEMBL) | |
| UBB(1-76) [cytosol] | Protein | P0CG47 (Uniprot-TrEMBL) | |
| UBB(153-228) [cytosol] | Protein | P0CG47 (Uniprot-TrEMBL) | |
| UBB(77-152) [cytosol] | Protein | P0CG47 (Uniprot-TrEMBL) | |
| UBC(1-76) [cytosol] | Protein | P0CG48 (Uniprot-TrEMBL) | |
| UBC(153-228) [cytosol] | Protein | P0CG48 (Uniprot-TrEMBL) | |
| UBC(229-304) [cytosol] | Protein | P0CG48 (Uniprot-TrEMBL) | |
| UBC(305-380) [cytosol] | Protein | P0CG48 (Uniprot-TrEMBL) | |
| UBC(381-456) [cytosol] | Protein | P0CG48 (Uniprot-TrEMBL) | |
| UBC(457-532) [cytosol] | Protein | P0CG48 (Uniprot-TrEMBL) | |
| UBC(533-608) [cytosol] | Protein | P0CG48 (Uniprot-TrEMBL) | |
| UBC(609-684) [cytosol] | Protein | P0CG48 (Uniprot-TrEMBL) | |
| UBC(77-152) [cytosol] | Protein | P0CG48 (Uniprot-TrEMBL) | |
| Ub | Protein | REACT_3316 (Reactome) | |
| VIF (P69723) protein [cytosol] | Protein | P69723 (Uniprot-TrEMBL) | |
| VIF (P69723) protein | Protein | P69723 (Uniprot-TrEMBL) | |
| VPR (P69726) protein [cytosol] | Protein | P69726 (Uniprot-TrEMBL) | |
| VPR (P69726) protein
[mitochondrial intermembrane space] | Protein | P69726 (Uniprot-TrEMBL) | |
| VPR (P69726) protein [nucleoplasm] | Protein | P69726 (Uniprot-TrEMBL) | |
| VPR (P69726) protein | Protein | P69726 (Uniprot-TrEMBL) | |
| VPU (P05919)
[endoplasmic reticulum membrane] | Protein | P05919 (Uniprot-TrEMBL) | |
| VPU (P05919) protein [cytosol] | Protein | P05919 (Uniprot-TrEMBL) | |
| VPU (P05919) | Protein | P05919 (Uniprot-TrEMBL) | |
| Vif:APOBEC3G complex | Complex | REACT_9662 (Reactome) | |
| Vif:Cul5:SCF complex | Complex | REACT_9902 (Reactome) | |
| Vpr:importin-alpha complex | Complex | REACT_8944 (Reactome) | |
| Vpu:beta-TrCP1:Skp1 complex | Complex | REACT_9101 (Reactome) | |
| XPO1 [cytosol] | Protein | O14980 (Uniprot-TrEMBL) | |
| XPO1 [nucleoplasm] | Protein | O14980 (Uniprot-TrEMBL) | |
| XPO1 | Protein | O14980 (Uniprot-TrEMBL) | |
| class I MHC complex | Complex | REACT_11465 (Reactome) | |
| multi-ubiquitinated
APOBEC3G:Vif:Cul5:SCF complex | Complex | REACT_9570 (Reactome) | |
| multiubiquitinated
CD4:Vpu:beta-TrCP_1:Skp1 complex | Complex | REACT_9344 (Reactome) | |
| myristoylated Nef
Protein (UniProt:P04601) [cytosol] | Protein | P04601 (Uniprot-TrEMBL) | |
| myristoylated Nef
Protein (UniProt:P04601) | Protein | P04601 (Uniprot-TrEMBL) | |
| nucleoporin-associated
Rev:Importin-beta:B23 complex | Complex | REACT_9793 (Reactome) | |
| p51 (RT) [cytosol] | Protein | P04585 (Uniprot-TrEMBL) | |
| p6 (P04585) protein [cytosol] | Protein | P04585 (Uniprot-TrEMBL) | |
| p6 (P04591) protein [cytosol] | Protein | P04591 (Uniprot-TrEMBL) |
Annotated Interactions
| View all... |
| Source | Target | Type | Database reference | Comment |
|---|---|---|---|---|
| 26S proteasome | mim-catalysis | REACT_9018 (Reactome) | ||
| 26S proteasome | mim-catalysis | REACT_9466 (Reactome) | ||
| ADP/ATP translocase monomer (generic) | REACT_7958 (Reactome) | |||
| ANT1:Vpr complex | Arrow | REACT_7958 (Reactome) | ||
| AP-1 Complex | Arrow | REACT_11147 (Reactome) | ||
| AP-1 Complex | REACT_11186 (Reactome) | |||
| AP-2 Complex | Arrow | REACT_11144 (Reactome) | ||
| AP-2 Complex | Arrow | REACT_11177 (Reactome) | ||
| AP-2 Complex | REACT_11091 (Reactome) | |||
| AP-2 Complex | REACT_11125 (Reactome) | |||
| AP2M1 | REACT_11122 (Reactome) | |||
| APOBEC3G:HIV-1PIC | Arrow | REACT_9450 (Reactome) | ||
| APOBEC3G:RTC with
deaminated minus sssDNA:tRNA primer:RNA template | Arrow | REACT_9435 (Reactome) | ||
| APOBEC3G:RTC with
minus sssDNA:tRNA primer:RNA template | Arrow | REACT_9444 (Reactome) | ||
| APOBEC3G:RTC with
minus sssDNA:tRNA primer:RNA template | REACT_9435 (Reactome) | |||
| APOBEC3G:Vif:Cul5:SCF complex | Arrow | REACT_9469 (Reactome) | ||
| APOBEC3G:Vif:Cul5:SCF complex | REACT_9471 (Reactome) | |||
| APOBEC3G:Vif:Cul5:SCF complex | mim-catalysis | REACT_9471 (Reactome) | ||
| APOBEC3G | REACT_9444 (Reactome) | |||
| APOBEC3G | REACT_9445 (Reactome) | |||
| APOBEC3G | REACT_9450 (Reactome) | |||
| APOBEC3G | mim-catalysis | REACT_9435 (Reactome) | ||
| ARF1(2-181) | REACT_11227 (Reactome) | |||
| ATP6V1H | Arrow | REACT_11144 (Reactome) | ||
| ATP6V1H | Arrow | REACT_11177 (Reactome) | ||
| ATP6V1H | REACT_11091 (Reactome) | |||
| ATP6V1H | REACT_11125 (Reactome) | |||
| Arf1:Nef:endosomal CD4 | Arrow | REACT_11227 (Reactome) | ||
| BTRC | REACT_9009 (Reactome) | |||
| CD247-1 | REACT_11221 (Reactome) | |||
| CD28:Nef:Clathrin-coated
Pit Adapter Protein Complex | Arrow | REACT_11122 (Reactome) | ||
| CD28:Nef:Clathrin-coated
Pit Adapter Protein Complex | REACT_11164 (Reactome) | |||
| CD28:Nef:Clathrin-coated Pit Adapter Protein | Arrow | REACT_11164 (Reactome) | ||
| CD28 | REACT_11194 (Reactome) | |||
| CD4:Lck Complex | REACT_11148 (Reactome) | |||
| CD4:Nef Complex | Arrow | REACT_11148 (Reactome) | ||
| CD4:Nef Complex | REACT_11091 (Reactome) | |||
| CD4:Nef:AP-2
Complex:v-ATPase Complex | Arrow | REACT_11091 (Reactome) | ||
| CD4:Nef:AP-2
Complex:v-ATPase Complex | REACT_11160 (Reactome) | |||
| CD4:Vpu complex | Arrow | REACT_9024 (Reactome) | ||
| CD4:Vpu complex | REACT_9009 (Reactome) | |||
| CD4:Vpu:beta-TrCP_1:Skp1 complex | Arrow | REACT_9071 (Reactome) | ||
| CD4:Vpu:beta-TrCP_1:Skp1 complex | REACT_9063 (Reactome) | |||
| CD4:Vpu:beta-TrCP_1:Skp1 complex | mim-catalysis | REACT_9063 (Reactome) | ||
| CD4:Vpu:beta-TrCP_1 | Arrow | REACT_9009 (Reactome) | ||
| CD4:Vpu:beta-TrCP_1 | REACT_9071 (Reactome) | |||
| CD4 | REACT_11227 (Reactome) | |||
| CD4 | REACT_9024 (Reactome) | |||
| CD8:Nef Complex | REACT_11125 (Reactome) | |||
| CD8:Nef:AP-2
Complex:v-ATPase Complex | Arrow | REACT_11125 (Reactome) | ||
| CD8:Nef:AP-2
Complex:v-ATPase Complex | REACT_11069 (Reactome) | |||
| Cul5-SCF complex | REACT_9469 (Reactome) | |||
| DOCK2:ELMO1:RAC1:Nef Complex | Arrow | REACT_11090 (Reactome) | ||
| DOCK2 | REACT_11090 (Reactome) | |||
| ELMO1 | REACT_11090 (Reactome) | |||
| FYN(2-537) | REACT_11075 (Reactome) | |||
| Fyn:Nef Complex | Arrow | REACT_11075 (Reactome) | ||
| GDP | Arrow | REACT_9507 (Reactome) | ||
| GTP | REACT_9507 (Reactome) | |||
| H2O | REACT_9435 (Reactome) | |||
| HCK(2-526) | REACT_11224 (Reactome) | |||
| HIV-1 mRNA | REACT_6161 (Reactome) | |||
| HIV-1 unspliced RNA | Arrow | REACT_6318 (Reactome) | ||
| Hck-1:Nef | Arrow | REACT_11224 (Reactome) | ||
| IN bound to sticky
3' ends of viral DNA in PIC | REACT_7952 (Reactome) | |||
| IN bound to sticky
3' ends of viral DNA in PIC | REACT_8011 (Reactome) | |||
| IN bound to sticky
3' ends of viral DNA in PIC | REACT_9450 (Reactome) | |||
| Importin beta-1:Rev multimer complex | Arrow | REACT_9394 (Reactome) | ||
| Importin beta-1:Rev multimer complex | REACT_9511 (Reactome) | |||
| Importin-beta:Ran GTP complex | Arrow | REACT_9456 (Reactome) | ||
| Internalized
CD4:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase | Arrow | REACT_11160 (Reactome) | ||
| Internalized
CD4:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase | REACT_11177 (Reactome) | |||
| Internalized
CD8:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase | Arrow | REACT_11069 (Reactome) | ||
| Internalized
CD8:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase | REACT_11144 (Reactome) | |||
| KPNA1 | REACT_8011 (Reactome) | |||
| KPNB1 | REACT_9394 (Reactome) | |||
| LCK | Arrow | REACT_11148 (Reactome) | ||
| LCK | REACT_11220 (Reactome) | |||
| Lck:Nef | Arrow | REACT_11220 (Reactome) | ||
| Lipid Raft | REACT_11221 (Reactome) | |||
| NH3 | Arrow | REACT_9435 (Reactome) | ||
| NPM1 | Arrow | REACT_9456 (Reactome) | ||
| NPM1 | REACT_9511 (Reactome) | |||
| Nef:CD28 Complex | Arrow | REACT_11194 (Reactome) | ||
| Nef:CD28 Complex | REACT_11122 (Reactome) | |||
| Nef:T cell Receptor
zeta:Lipid Raft: Pak 2 Complex | Arrow | REACT_11221 (Reactome) | ||
| Nef:class I MHC
complex:AP-1:PACS-1 Complex | Arrow | REACT_11229 (Reactome) | ||
| Nef:class I MHC
complex:AP-1:PACS-1 Complex | REACT_11147 (Reactome) | |||
| Nef:class I MHC
complex:Ap-1:PACS-1 Complex | Arrow | REACT_11186 (Reactome) | ||
| Nef:class I MHC
complex:Ap-1:PACS-1 Complex | REACT_11229 (Reactome) | |||
| Nef:class I MHC complex | Arrow | REACT_11071 (Reactome) | ||
| Nef:class I MHC complex | REACT_11186 (Reactome) | |||
| Nuclear Pore Complex (NPC) | Arrow | REACT_6340 (Reactome) | ||
| Nuclear Pore Complex (NPC) | Arrow | REACT_9521 (Reactome) | ||
| Nuclear Pore Complex (NPC) | REACT_6337 (Reactome) | |||
| Nuclear Pore Complex (NPC) | REACT_7952 (Reactome) | |||
| Nuclear Pore Complex (NPC) | REACT_9516 (Reactome) | |||
| P-TEFb(Cyclin T1:Cdk9) complex | REACT_6356 (Reactome) | |||
| PACS1(2-963) | Arrow | REACT_11147 (Reactome) | ||
| PACS1(2-963) | REACT_11186 (Reactome) | |||
| PAK2(1-524) | REACT_11221 (Reactome) | |||
| PIC anchored to the NPC | Arrow | REACT_7952 (Reactome) | ||
| Pi | Arrow | REACT_6171 (Reactome) | ||
| RAC1-1 | REACT_11090 (Reactome) | |||
| RANBP1(2-201) | Arrow | REACT_6171 (Reactome) | ||
| RANBP1(2-201) | Arrow | REACT_6318 (Reactome) | ||
| RANBP1(2-201) | REACT_9478 (Reactome) | |||
| RANGAP1 | Arrow | REACT_6171 (Reactome) | ||
| RCC1 | mim-catalysis | REACT_9507 (Reactome) | ||
| REACT_11069 (Reactome) | The CD8alphabeta receptor is internalized via endocytosis. | |||
| REACT_11071 (Reactome) | Nef disrupts the transport of major histocompatibility complex class I molecules by first binding to the the cytoplasmic side of the transmembrane complex. | |||
| REACT_11075 (Reactome) | Nef has been shown to bind specifically to a subset of the Src family of kinases. Nef/Fyn interaction centers on a proline-rich motif (Pro-x-x-Pro), which is implicated in SH3 binding. This domain is partially disordered in the absence of the binding partner; when bound this motif fully adopts a left-handed polyproline type II helix conformation upon complex formation with the Fyn SH3 domain. Within this structure the arginine residue (Arg77) of Nef interacts with Asp 100 of the RT loop within the Fyn SH3 domain, and triggers a hydrogen-bond rearrangement which allows the loop to adapt to complement the Nef surface. The Arg96 residue of the Fyn SH3 domain is specifically accommodated in the same hydrophobic pocket of Nef. The Nef-Fyn complex forms in vivo and may have a crucial role in the T cell perturbating action of Nef by altering T cell receptor signaling. | |||
| REACT_11090 (Reactome) | The infectious cycle of primate lentiviruses is intimately linked to interactions between cells of the immune system. Nef, a potent virulence factor, alters cellular environments to increase lentiviral replication in the host, functioning as an adaptor protein. Nef activates Rac in T cell lines and in primary T cells following infection with HIV-1 in the absence of antigenic stimuli. Nef activates Rac by binding the DOCK2-ELMO1 complex, and this interaction is linked to the abilities of Nef to inhibit chemotaxis and promote T cell activation. Nef targets a critical switch that regulates Rac GTPases downstream of chemokine- and antigen-initiated signaling pathways. This interaction enables Nef to influence multiple aspects of T cell function and thus provides an important mechanism by which Nef impacts pathogenesis by primate lentiviruses. | |||
| REACT_11091 (Reactome) | AP-2 is recruited to the newly formed Nef:CD4 complex | |||
| REACT_11122 (Reactome) | Nef induces accelerated endocytosis of CD28 via clathrin-coated pits. | |||
| REACT_11125 (Reactome) | The presence of Nef accelerates endocytosis and lysosomal degradation of the transmembrane glycoprotein CD8. Nef facilitates a cascade of protein interactions that ultimately result in the degradation of internalized CD8 protein. The final set of protein interactions that direct Nef to the beta-subunit of the COPI coatomers are at this time unclear. A number of sites within Nef are proposed to be required for CD8 down-regulation, the myristoylation signal and N-terminal anchor regions, the C-terminal flexible loop, and amino acid positions 57 to 58. Consistent with all reported Nef functions, the myristoylation signal was found to be essential for CD8 down-modulation. The flexible loop contains a dileucine-based internalization motif, which is flanked by acidic clusters and is involved in enhanced internalization of the Nef-CD4 complex. | |||
| REACT_11144 (Reactome) | Once the CD8alphabeta receptor has been internalized via endocytosis, the vesicles are targeted for lysosomal degradation. | |||
| REACT_11147 (Reactome) | Once the complex of Nef, major histocompatibility complex class I molecules, PACS-1 and AP-1 arrives at the endosome, the MHC I complex is targeted for degradation. | |||
| REACT_11148 (Reactome) | Nef disrupts the CD4 Lck complex | |||
| REACT_11160 (Reactome) | The Nef:CD4:AP-2 complex is internalized | |||
| REACT_11164 (Reactome) | Once Nef has induced endocytosis of CD28, CD28 containing vesicles are targeted for lysosomal degradation. | |||
| REACT_11177 (Reactome) | CD4 is degraded | |||
| REACT_11186 (Reactome) | The complex formed by Nef and the major histocompatibility complex class I molecules creates binding sites for PACS-1 and the AP-1 complex. | |||
| REACT_11194 (Reactome) | Down-regulation of CD28 receptors involves a dileucine-based motif in the second disordered loop of Nef, which connects Nef to adaptor protein (AP) complex, which is a part of cellular endocytosis machinery. | |||
| REACT_11220 (Reactome) | The Nef protein of the primate lentiviruses, including human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV), is a myristylated protein associated with increased viral replication and enhanced pathogenicity. Both the potentiation of T-lymphocyte activation and the enhanced serine-phosphorylation of HIV-1 capsid by Nef correlate with increased viral replication. The Nef proteins from HIV-1 and SIV bind to Lck. The SH3 and SH2 domains of Lck are sufficient for coprecipitation with non-tyrosine-phosphorylated Nef proteins. The conserved core region of HIV-1 Nef is essential for the interaction with Lck and is also important for enhanced HIV-1 replication in T-lymphocytes. The SIV and HIV-1 Nef proteins are differentially tyrosine-phosphorylated. The kinase-active Lck tyrosine-phosphorylates SIVmac239 Nef but does not phosphorylate HIV-1 Nef. | |||
| REACT_11221 (Reactome) | Nef drives the formation of lipid raft complexes. | |||
| REACT_11224 (Reactome) | The protein Hck is a member of the Src family of non-receptor tyrosine kinases which is preferentially expressed in haematopoietic cells of the myeloid and B-lymphoid lineages. Src kinases are inhibited by tyrosine-phosphorylation at a carboxy-terminal site. The SH2 domains of these enzymes play an essential role in this regulation by binding to the tyrosine-phosphorylated tail. The SH2 domain of Hck regulates enzymatic activity indirectly; intramolecular interactions between the SH3 and catalytic domains appear to stabilize an inactive form of the kinase. The HIV-1 Nef protein, which is a high-affinity ligand for the Hck SH3 domain, binds to either the downregulated or activated form of Hck causing a large increase in Hck catalytic activity. The intact SH3-binding motif in Nef is crucial for Hck activation. | |||
| REACT_11227 (Reactome) | The HIV Nef protein downregulates CD4 through sequential connection with clathrin-coated pits and the COP1 coatomer, resulting in accelerated endocytosis and lysosomal targeting. The small GTPase ARF1 controls the Nef-induced, COP-mediated late-endosomal targeting of CD4. Nef binds ARF1 directly and can recruit the GTPase onto endosomal membranes, leading to the eventual degradation of CD4 (Faure et al. 2004). | |||
| REACT_11229 (Reactome) | The complex of Nef, major histocompatibility complex class I molecules, PACS-1 and AP-1 is transported from the trans-Golgi network to an endosome, where the MHC I complex will be degraded. | |||
| REACT_6140 (Reactome) | RanGTP binds to a preformed Rev-CRM1 complex. | |||
| REACT_6161 (Reactome) | Nuclear export of the unspliced and partially spliced HIV-1 transcripts requires the association of the HIV-1 Rev protein with a cis-acting RNA sequence known as the Rev Response Element (RRE) located within the env gene. The RRE forms a stem loop structure that associates with an arginine-rich RNA binding motif (ARM) within Rev. | |||
| REACT_6171 (Reactome) | Ran-GAP, a Ran-specific GTPase-activating protein converts Ran-GTP to Ran-GDP, producing a Ran-GTP gradient across the nuclear membrane. | |||
| REACT_6228 (Reactome) | In order for Rev to function, multiple molecules must bind sequentiallly to the RRE (Malim and Cullen 1991). | |||
| REACT_6318 (Reactome) | The association of RanBp1 with RanGTP:CRM1:Rev promotes disassembly of the complex and release of the Rev:RNA cargo. | |||
| REACT_6337 (Reactome) | The Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP complex associates with the NPC. | |||
| REACT_6340 (Reactome) | Crm1 is a nucleocytoplasmic transport factor that is believed to interact with nucleoporins facilitating docking of the RRE-Rev-CRM1-RanGTP complex to the nuclear pore and the translocation of the complex across the nuclear pore complex (see Cullen 1998) Crm1 has been found in complex with two such nucleoporins, CAN/Nup214 and Nup88 which have been shown to be components of the human nuclear pore complex (Fornerod et al., 1997). | |||
| REACT_6356 (Reactome) | Tat associates with the Cyclin T1 subunit of P-TEFb (Cyclin T1:Cdk9) through a region of cysteine-rich and core sequences referred to as the ARM domain within Tat (Wei et al., 1998; see also Herrmann 1995). This interaction is believed to involve metal ions stabilized by cysteine residues in both proteins (Bieniasz et al., 1998; Garber et al., 1998). | |||
| REACT_7952 (Reactome) | ||||
| REACT_7958 (Reactome) | Vpr interacts with the PTPC component ANT1. This interaction induces mitochondrial membrane permeabilization and release of cytochrome c and apoptotic factors. | |||
| REACT_7969 (Reactome) | Vpr translocates to the mitochondria. | |||
| REACT_8011 (Reactome) | Vpr interacts with importin-alpha through alphaH1 and alphaH2. The interaction via alphaH1 is indispensable for the nuclear entry of Vpr (Kamata et al., 2005) . | |||
| REACT_9009 (Reactome) | Vpu links beta-TrCP to CD4 at the ER membrane through interactions with beta-TrCP and the cytoplasmic tail of CD4. | |||
| REACT_9018 (Reactome) | Ubiquitinated CD4 is then subject to proteasome-mediated degradation. | |||
| REACT_9024 (Reactome) | Vpu is expressed in the ER and associates with a membrane-proximal region in the cytoplasmic tail of CD4. | |||
| REACT_9063 (Reactome) | CD4 is ubiquitinated in the CD4:Vpu–h-βTrCP:Skp1 complex. | |||
| REACT_9071 (Reactome) | The SKP1 component of the SCF complex is recruited to the Vpu:beta-TrCP:CD4 complex. | |||
| REACT_9394 (Reactome) | The association of Rev with importin-beta is mediated by the Rev nuclear localisation signal. | |||
| REACT_9399 (Reactome) | Inside the nucleus, Ran-GTP associates with importin-beta. | |||
| REACT_9435 (Reactome) | During reverse transcription, APOBEC3G-mediated minus-strand deamination occurs within a CC dinucleotide context over the entire length of the HIV-1 genome (Yu et al., 2004). The polypurine tract is essential for plus strand synthesis and is located at the 3’ end of the retroviral genome. HIV-1 encodes an additional central polypurine tract located in the middle of the genome which also serves as primer for plus strand synthesis. Deamination of the minus strand continues throughout its synthesis with the frequency of deamination events increasing from the 5’ to 3’ regions. A 400bp region downstream of the central polypurine tract seems to be protected from deamination (Wurtzer et al., 2006) | |||
| REACT_9444 (Reactome) | In the target cell, HIV-1-associated APOBEC3G binds to the HIV-1 reverse transcript minus strand and catalyzes the deamination of cytidines in a specific dinucleotide context (e.g., dCC). In contrast, APOBEC3F and APOBEC3B display a preference for dTC. | |||
| REACT_9445 (Reactome) | The HIV-1 Vif protein associates with the DNA editing enzyme APOBEC3G Marin et al) . The binding site has not yet been mapped but emerging evidence suggest that the N-terminal lregion of Vif is essential for APOBEC3G recognition (Tian et al) . Substitution of a single amino acid in the human APOBEC3G (Asp128Lys) abolishes binding and renders it resistant to HIV-1 Vif (Schrofelbauer et al; Bogerd et al.). | |||
| REACT_9450 (Reactome) | APOBEC3G is incorporated into virus particles through its association with components of the viral RNA packaging machinery. It binds to the nucleocapsid portion of Gag (NC), a region of the polyprotein that associates with genomic RNA and functions in RNA encapsidation. | |||
| REACT_9456 (Reactome) | The association of importin-beta with Ran-GTP causes the disassembly of the Rev-importin β-B23 complex releasing the Rev in the nucleus. | |||
| REACT_9466 (Reactome) | Following multi-ubiquitination by the Vif-Cul5-SCF complex, APOBEC3G is degraded by the 26S proteasome. | |||
| REACT_9469 (Reactome) | The interaction between Vif and the E3 ubiquitin ligase complex (Cullin5, Elongin B and Elongin C, and Rbx1) takes place through direct binding of the SOCS box motif in the viral protein Vif to the host protein Elongin C. Moreover, a conserved HCCH motif in Vif allows binding to Cullin 5. | |||
| REACT_9471 (Reactome) | APOBEC3G is multi-ubiquitinated by the Vif-Cul5-SCF complex. | |||
| REACT_9478 (Reactome) | Upon translocation to the cytoplasm, RanBP1 associates with Ran-GTP in the Rev-CRM1-Ran-GTP complex. | |||
| REACT_9507 (Reactome) | Free, nuclear RanGTP is required for export processes out of the nucleus. RCC1 catalyses the conversion of Ran-GDP to Ran-GTP in the nucleus. | |||
| REACT_9511 (Reactome) | B23 may function as a shuttle for the import of HIV Rev from the cytoplasm into the nucleus or nucleolus permitting additional rounds of export of viral RNAs. | |||
| REACT_9516 (Reactome) | The Rev-importin β-B23 complex is recruited to the nuclear pore by an interaction between importin β and nucleoporin. | |||
| REACT_9521 (Reactome) | Following the association of Rev with importin-beta, the Rev:B23:importin-beta complex is imported into the nucleus. | |||
| REACT_9530 (Reactome) | CRM1 associates directly with Rev through the Rev nuclear export signal (NES) domain and acts as the nuclear export receptor for the Rev-RRE ribonucleoprotein complex. | |||
| REV (P04618) protein | Arrow | REACT_6318 (Reactome) | ||
| REV (P04618) protein | REACT_6161 (Reactome) | |||
| RTC with minus
sssDNA:tRNA primer:RNA template | REACT_9444 (Reactome) | |||
| Ran GTPase:GDP | Arrow | REACT_6171 (Reactome) | ||
| Ran-GDP | REACT_9507 (Reactome) | |||
| Ran-GTP | Arrow | REACT_9507 (Reactome) | ||
| Ran-GTP | REACT_6140 (Reactome) | |||
| Ran-GTP | REACT_9399 (Reactome) | |||
| Ran:GTP | Arrow | REACT_6318 (Reactome) | ||
| Ran:GTP | REACT_6171 (Reactome) | |||
| RanBP1:Ran-GTP:CRM1:Rev-bound mRNA complex | Arrow | REACT_9478 (Reactome) | ||
| RanBP1:Ran-GTP:CRM1:Rev-bound mRNA complex | REACT_6318 (Reactome) | |||
| Rev multimer-bound
HIV-1 mRNA:Crm1:Ran:GTP:NPC | Arrow | REACT_6337 (Reactome) | ||
| Rev multimer-bound
HIV-1 mRNA:Crm1:Ran:GTP:NPC | REACT_6340 (Reactome) | |||
| Rev multimer-bound
HIV-1 mRNA:Crm1:Ran:GTP | Arrow | REACT_6140 (Reactome) | ||
| Rev multimer-bound
HIV-1 mRNA:Crm1:Ran:GTP | Arrow | REACT_6340 (Reactome) | ||
| Rev multimer-bound
HIV-1 mRNA:Crm1:Ran:GTP | REACT_6337 (Reactome) | |||
| Rev multimer-bound
HIV-1 mRNA:Crm1:Ran:GTP | REACT_9478 (Reactome) | |||
| Rev multimer-bound
HIV-1 mRNA:Crm1:Ran:GTP | mim-catalysis | REACT_6171 (Reactome) | ||
| Rev multimer-bound
HIV-1 mRNA:CRM1 complex | Arrow | REACT_9530 (Reactome) | ||
| Rev multimer-bound
HIV-1 mRNA:CRM1 complex | REACT_6140 (Reactome) | |||
| Rev multimer-bound HIV-1 mRNA | Arrow | REACT_6228 (Reactome) | ||
| Rev multimer-bound HIV-1 mRNA | REACT_9530 (Reactome) | |||
| Rev-bound HIV-1 mRNA | Arrow | REACT_6161 (Reactome) | ||
| Rev-bound HIV-1 mRNA | REACT_6228 (Reactome) | |||
| Rev-multimer | Arrow | REACT_6318 (Reactome) | ||
| Rev-multimer | Arrow | REACT_9456 (Reactome) | ||
| Rev-multimer | REACT_6228 (Reactome) | |||
| Rev-multimer | REACT_9394 (Reactome) | |||
| Rev:Importin-beta:B23 | Arrow | REACT_9521 (Reactome) | ||
| Rev:Importin-beta:B23 | REACT_9399 (Reactome) | |||
| Rev:Importin-beta:NPM1 | Arrow | REACT_9511 (Reactome) | ||
| Rev:Importin-beta:NPM1 | REACT_9516 (Reactome) | |||
| Rev:importin-beta:B23:Ran-GTP complex | Arrow | REACT_9399 (Reactome) | ||
| Rev:importin-beta:B23:Ran-GTP complex | REACT_9456 (Reactome) | |||
| SKP1 | REACT_9071 (Reactome) | |||
| Tat (P04608) | REACT_6356 (Reactome) | |||
| Tat:P-TEFb(Cyclin T1:Cdk9) complex | Arrow | REACT_6356 (Reactome) | ||
| Ub | Arrow | REACT_9018 (Reactome) | ||
| Ub | Arrow | REACT_9466 (Reactome) | ||
| Ub | REACT_9063 (Reactome) | |||
| Ub | REACT_9471 (Reactome) | |||
| VIF (P69723) protein | REACT_9445 (Reactome) | |||
| VPR (P69726) protein | Arrow | REACT_7969 (Reactome) | ||
| VPR (P69726) protein | REACT_7958 (Reactome) | |||
| VPR (P69726) protein | REACT_7969 (Reactome) | |||
| VPU (P05919) | REACT_9024 (Reactome) | |||
| Vif:APOBEC3G complex | Arrow | REACT_9445 (Reactome) | ||
| Vif:APOBEC3G complex | REACT_9469 (Reactome) | |||
| Vif:Cul5:SCF complex | Arrow | REACT_9466 (Reactome) | ||
| Vpr:importin-alpha complex | Arrow | REACT_8011 (Reactome) | ||
| Vpu:beta-TrCP1:Skp1 complex | Arrow | REACT_9018 (Reactome) | ||
| XPO1 | Arrow | REACT_6318 (Reactome) | ||
| XPO1 | REACT_9530 (Reactome) | |||
| class I MHC complex | REACT_11071 (Reactome) | |||
| multi-ubiquitinated
APOBEC3G:Vif:Cul5:SCF complex | Arrow | REACT_9471 (Reactome) | ||
| multi-ubiquitinated
APOBEC3G:Vif:Cul5:SCF complex | REACT_9466 (Reactome) | |||
| multiubiquitinated
CD4:Vpu:beta-TrCP_1:Skp1 complex | Arrow | REACT_9063 (Reactome) | ||
| multiubiquitinated
CD4:Vpu:beta-TrCP_1:Skp1 complex | REACT_9018 (Reactome) | |||
| myristoylated Nef
Protein (UniProt:P04601) | Arrow | REACT_11144 (Reactome) | ||
| myristoylated Nef
Protein (UniProt:P04601) | Arrow | REACT_11147 (Reactome) | ||
| myristoylated Nef
Protein (UniProt:P04601) | Arrow | REACT_11177 (Reactome) | ||
| myristoylated Nef
Protein (UniProt:P04601) | REACT_11071 (Reactome) | |||
| myristoylated Nef
Protein (UniProt:P04601) | REACT_11075 (Reactome) | |||
| myristoylated Nef
Protein (UniProt:P04601) | REACT_11090 (Reactome) | |||
| myristoylated Nef
Protein (UniProt:P04601) | REACT_11148 (Reactome) | |||
| myristoylated Nef
Protein (UniProt:P04601) | REACT_11194 (Reactome) | |||
| myristoylated Nef
Protein (UniProt:P04601) | REACT_11220 (Reactome) | |||
| myristoylated Nef
Protein (UniProt:P04601) | REACT_11221 (Reactome) | |||
| myristoylated Nef
Protein (UniProt:P04601) | REACT_11224 (Reactome) | |||
| myristoylated Nef
Protein (UniProt:P04601) | REACT_11227 (Reactome) | |||
| nucleoporin-associated
Rev:Importin-beta:B23 complex | Arrow | REACT_9516 (Reactome) | ||
| nucleoporin-associated
Rev:Importin-beta:B23 complex | REACT_9521 (Reactome) |
