Signaling by the B Cell Receptor (BCR) (Homo sapiens)

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14, 16, 22, 25-27, 34...40, 85, 99, 14013118, 52, 84, 116, 137...36, 41, 74, 81, 88...24, 58, 93, 1435, 43, 50, 77, 97...35, 67, 75, 76, 80104, 106, 13112, 23, 71, 72, 102...115, 117, 126, 14827, 86, 9044, 51, 91, 125, 13424, 38, 55, 58, 62...4, 37, 66, 136, 13931, 33, 92, 1303, 7, 8, 10, 19...6, 25, 13127, 86, 9015, 53, 82, 91, 11111, 30, 56, 64, 79...37, 66, 13957, 83, 124, 145, 14621, 22, 26, 42, 117...2, 14, 16, 41, 95...1, 13, 17, 28, 29, 59...6, 25, 73, 105, 10618, 52, 84, 116, 137...Ig Antibody LightChain [plasmamembrane]NF-kappaB p50:p50[cytosol]Ig Kappa Light ChainV Region [plasmamembrane]NF-kappaBp50/p65/c-Rel Dimer[nucleoplasm]Ig Lamda Light ChainV Region [plasmamembrane]NF-kappaB p50:p50[cytosol]IgD Heavy Chain[plasma membrane]Calcineurin (CaN)[cytosol]IgM Heavy Chain[plasma membrane]Ig Heavy Chain VRegion [plasmamembrane]IgM Heavy Chain[plasma membrane]IgM [plasmamembrane]ImmunoglobulinLambda Light Chain[plasma membrane]IgD [plasmamembrane]p21 RAS:GTP [plasmamembrane]CARMA1:BCL10:MALT1:TAK1:IKK[plasma membrane]Ig Lamda Light ChainV Region [plasmamembrane]IgM Heavy Chain[plasma membrane]FKBP1A:Tacrolimus[cytosol]Ig Kappa Light ChainV Region [plasmamembrane]NF-kB complex[cytosol]Ig Heavy Chain VRegion [plasmamembrane]Active IKK complex[cytosol]Activated PKC beta[plasma membrane]IgM Heavy Chain[plasma membrane]NF-kappaBp50:p65:p-IKB[cytosol]p-CARMA1 Oligomer[plasma membrane]NF-kappaBp50/p65/c-Rel:ub-p-IKB[cytosol]NF-kappaBp50:p65:p-IKB[cytosol]NF-kappa-B p50/p65/c-Rel:p-IKB[cytosol]SCF-beta-TrCp1/2[cytosol]IgD [plasmamembrane]Ig Kappa Light ChainV Region [plasmamembrane]CyclophilinA:Cyclosporin A[cytosol]NF-kB complex[cytosol]CRAC channel [plasmamembrane]NF-kappaB:p-IkB:SCF-betaTrCP[cytosol]PPP3CA/B:Calmodulin[cytosol]CARMA1:MALT1:BCL10[plasma membrane]p-RasGRP1,3:DAG[plasma membrane]Antigen:p-BCR[plasma membrane]IKBalpha/beta/epsilon[cytosol]p-PLC gamma1/2[plasma membrane]Antigen:p-BCR:p-SYK[plasma membrane]IKKA:IKKB:NEMO[cytosol]CARMA1 oligomer[cytosol]STIM1:TRPC1[endoplasmicreticulum membrane,plasma membrane]NF-kappaB p65:p65[cytosol]p-BCR [plasmamembrane]NF-kappaB p50:p50[cytosol]PPP3CA/B:Fe3+:Zn2+[cytosol]BLNK:GRB2:SOS1:CIN85:CBL[cytosol]SCF-beta-TrCp1/2[cytosol]p-IKBalpha/beta/epsilon[cytosol]IgD [plasmamembrane]p-BCR [plasmamembrane]Ig Lambda C region[plasma membrane]Antigen:p-BCR[plasma membrane]NF-kappaB p50:p50[nucleoplasm]NF-kappaB p50:c-Rel[cytosol]NF-kappaB p50:p50[cytosol]p-BCR [plasmamembrane]Ig Kappa Light ChainV Region [plasmamembrane]SCF-beta-TrCP2complex [cytosol]Orai1 dimer [plasmamembrane]ImmunoglobulinLambda Light Chain[plasma membrane]Antigen:BCR [plasmamembrane]Ig Lamda Light ChainV Region [plasmamembrane]PIK3CD:PIK3R1[cytosol]NF-kappaB p65:p65[cytosol]Antigen:p-BCR:p-SYK[plasma membrane]NF-kappaBp65:p65:IKB[cytosol]ImmunoglobulinLambda Light Chain[plasma membrane]Ig Lambda C region[plasma membrane]ub-p-IKBalpha/beta/epsilon[cytosol]Calcineurin alpharegulatorysubunit:Calcium[cytosol]p21 RAS [plasmamembrane]Immunoglobulin KappaLight Chain [plasmamembrane]Antigen:p-BCR:p-SYK:p-BLNK[plasma membrane]IP3 receptor:IP3complex [endoplasmicreticulum membrane]cytosolNF-KappaBp50:p50:IKBA[cytosol]IgM Heavy Chain[plasma membrane]Ig Kappa Light ChainV Region [plasmamembrane]ImmunoglobulinLambda Light Chain[plasma membrane]p-CARMA1 Oligomer[plasma membrane]endoplasmic reticulum lumenCalcineurin:PhosphorylatedNFATC1/2/3 [cytosol]Immunoglobulin KappaLight Chain [plasmamembrane]IgD [plasmamembrane]p-BCR [plasmamembrane]p-IKBalpha/beta/epsilon[cytosol]PhosphorylatedNFATC1/2/3 [cytosol]IgM or IgD [plasmamembrane]NF-kappaBp50:p65:ub-p-IKB[cytosol]NF-KappaBp50:p50:p-IKBA[cytosol]NF-kappaBp50:c-Rel:p-IKB[cytosol]STIM1 Dimer[endoplasmicreticulum membrane]NF-kappaBp65:p65:ub-p-IkB[cytosol]PIK3CD:PIK3R1[plasma membrane]NF-kappaBp65:p65:p-IKB[cytosol]IgM or IgD [plasmamembrane]NF-kB complex[cytosol]IgM [plasmamembrane]p-PLC gamma1,2:PIP3[plasma membrane]Antigen:p-BCR[plasma membrane]Ig Antibody LightChain [plasmamembrane]IP3 receptors[endoplasmicreticulum membrane]IgM or IgD [plasmamembrane]Immunoglobulin KappaLight Chain [plasmamembrane]NF-kappaBp50:p65:IKB[cytosol]CARMA1:BCL10:MALT1:TAK1[plasma membrane]NF-kB complex[cytosol]BCR [plasmamembrane]PPP3CA/B [cytosol]Ig Lambda C region[plasma membrane]IgM [plasmamembrane]NF-kB complex[cytosol]IP3 receptorhomotetramer[endoplasmicreticulum membrane]STIM1 Dimer[endoplasmicreticulum membrane]IgD [plasmamembrane]IgM Heavy Chain[plasma membrane]Immunoglobulin KappaLight Chain [plasmamembrane]NF-kappaBp50/p65/c-Rel Dimer[cytosol]IgD [plasmamembrane]IgD Heavy Chain[plasma membrane]Antigen:p-BCR:p-SYK[plasma membrane]BLNK (SLP-65)Signalosome [plasmamembrane]BCAP Signalosome[plasma membrane]STIM1 Dimer[endoplasmicreticulum membrane]Antigen:p-BCR:p-SYK:p-BLNK[plasma membrane]NF-kappaB p50:p50[cytosol]NF-KappaBp50:p50:ub-p-IKBA[cytosol]Ig Heavy Chain VRegion [plasmamembrane]plasma membranep-RasGRP1/3 [plasmamembrane]Antigen:p-BCR[plasma membrane]IKKA:IKKB:NEMO[plasma membrane]p-BCR [plasmamembrane]NF-kappaBp50:c-Rel:ub-p-IKB[cytosol]NF-kappaBp65:p65:p-IKB[cytosol]IP3 receptors[endoplasmicreticulum membrane]CD19 Signalosome[plasma membrane]NF-kappa-B p50/p65/c-Rel:p-IKB[cytosol]ImmunoglobulinLambda Light Chain[plasma membrane]IgM [plasmamembrane]Ig Heavy Chain VRegion [plasmamembrane]NF-kappaB p65:p65[cytosol]NF-kappaB p65:p65[cytosol]ImmunoglobulinLambda Light Chain[plasma membrane]IgM [plasmamembrane]p-BLNK:GRB2:SOS1:CIN85:CBL[plasma membrane]Active Calmodulin[cytosol]IgM [plasmamembrane]PPP3CA/B [cytosol]Ig Lambda C region[plasma membrane]ImmunoglobulinLambda Light Chain[plasma membrane]p-SHC1 p46/p52[plasma membrane]IgD Heavy Chain[plasma membrane]Orai1 dimer [plasmamembrane]Ig Lamda Light ChainV Region [plasmamembrane]IP3 receptorhomotetramer[endoplasmicreticulum membrane]IgM or IgD [plasmamembrane]SCF-beta-TrCP1complex [cytosol]p21 RAS [plasmamembrane]Ig Heavy Chain VRegion [plasmamembrane]Ig Antibody LightChain [plasmamembrane]Ig Lamda Light ChainV Region [plasmamembrane]CARMA1:MALT1:BCL10[plasma membrane]PIK3CD:PIK3R1[plasma membrane]Antigen:p-BCR[plasma membrane]NF-kappaB p50:c-Rel[nucleoplasm]p21 RAS:GDP [plasmamembrane]p-BAM32:PIP3 [plasmamembrane]p-BLNK:GRB2:SOS1:CIN85:CBL[plasma membrane]IgM or IgD [plasmamembrane]Ig Antibody LightChain [plasmamembrane]NF-KappaBp50:p50:p-IKBA[cytosol]STIM1:Calcium[endoplasmicreticulum membrane]IgM or IgD [plasmamembrane]Active Calmodulin[cytosol]IgD Heavy Chain[plasma membrane]Ig Antibody LightChain [plasmamembrane]NF-kappaB p50:c-Rel[cytosol]Ig Heavy Chain VRegion [plasmamembrane]Immunoglobulin KappaLight Chain [plasmamembrane]p-CARMA1 Oligomer[plasma membrane]NF-kappaBp50:c-Rel:p-IKB[cytosol]NF-kB complex[nucleoplasm]p-CARMA1 Oligomer[plasma membrane]NF-kappaB p50:c-Rel[cytosol]p-BTK:PIP3 [plasmamembrane]IgD [plasmamembrane]NF-kappaB p65:p65[cytosol]PIK3CD:PIK3R1[plasma membrane]Ig Heavy Chain VRegion [plasmamembrane]CARMA1:MALT1:BCL10[plasma membrane]BCR [plasmamembrane]IgM or IgD [plasmamembrane]NF-kappaB p50:c-Rel[cytosol]IgD Heavy Chain[plasma membrane]SCF-beta-TrCP2complex [cytosol]Ig Lambda C region[plasma membrane]Ig Lambda C region[plasma membrane]Ig Lamda Light ChainV Region [plasmamembrane]NF-kappa-Bp50,/p65,/c-Rel:IKB[cytosol]SCF-beta-TrCP1complex [cytosol]NF-kappaB p65:p65[nucleoplasm]IgD Heavy Chain[plasma membrane]CD19:VAV1 [plasmamembrane]26S proteasome[cytosol]nucleoplasmImmunoglobulin KappaLight Chain [plasmamembrane]Calcineurin:Calmodulin(CaN:CaM) [cytosol]Ig Kappa Light ChainV Region [plasmamembrane]NF-kappaB p50:c-Rel[cytosol]IgD Heavy Chain[plasma membrane]Ig Lamda Light ChainV Region [plasmamembrane]NF-kappaBp50:c-Rel:IkB[cytosol]Ig Lambda C region[plasma membrane]IgM Heavy Chain[plasma membrane]PPP3CA/B:Fe3+:Zn2+[cytosol]Immunoglobulin KappaLight Chain [plasmamembrane]Antigen:p-BCR:SYK[plasma membrane]Ig Antibody LightChain [plasmamembrane]IgM [plasmamembrane]Ig Antibody LightChain [plasmamembrane]Ig Kappa Light ChainV Region [plasmamembrane]CUL1 [cytosol]Ig heavy chain V-IIIregion GA [plasmamembrane]Ig kappa chain V-Iregion Rei [plasmamembrane]Ig lambda chain V-Iregion HA [plasmamembrane]Ig kappa chain V-Iregion BAN [plasmamembrane]PSMD5 [cytosol]Ig kappa chain V-IVregion Len [plasmamembrane]Ig lambda chain V-Iregion EPS [plasmamembrane]IGKC(1-106) [plasmamembrane]Ig lambda chain V-Iregion BL2 [plasmamembrane]Ig heavy chain V-IIIregion TRO [plasmamembrane]Ig heavy chain V-IIIregion LAY [plasmamembrane]Ig heavy chain V-Iregion HG3 [plasmamembrane]p-Y139-DAPP1 [plasmamembrane]Ig kappa chain V-Iregion Roy [plasmamembrane]Ig heavy chain V-IIregion SESS [plasmamembrane]Ig lambda chain V-Iregion WAH [plasmamembrane]Ig kappa chain V-Iregion CAR [plasmamembrane]Ig kappa chain V-Iregion Walker[plasma membrane]Ig heavy chain V-IIregion OU [plasmamembrane]Ig kappa chain V-IIregion GM607 [plasmamembrane]Ig lambda chain V-IIregion NEI [plasmamembrane]Ig lambda chain V-Vregion DEL [plasmamembrane]Ig heavy chain V-IIregion NEWM [plasmamembrane]Ig lambda chain V-IVregion MOL [plasmamembrane]IGKV1-5(23-?)[plasma membrane]Ig kappa chain V-IIIregion VG [plasmamembrane]Ig kappa chain V-IIIregion WOL [plasmamembrane]Ig kappa chain V-IIIregion SIE [plasmamembrane]Ig heavy chain V-IIIregion WAS [plasmamembrane]SHC1 p46/p52GRB2-1 [plasmamembrane]Ig kappa chain V-Iregion Walker[plasma membrane]p-S32,S36-NFKBIA[cytosol]Ig heavy chain V-IIIregion TIL [plasmamembrane]Ig lambda chainV-III region LOI[plasma membrane]Ig lambda chain V-IIregion TRO [plasmamembrane]Ig lambda chain V-IIregion BOH [plasmamembrane]MAP3K7Ig kappa chain V-IIIregion WOL [plasmamembrane]PPP3CB(2-524)[cytosol]VAV1Active IKK complexIg heavy chain V-IIregion NEWM [plasmamembrane]Ig lambda chain V-Iregion HA [plasmamembrane]Ig kappa chain V-IIIregion VH [plasmamembrane]Ig heavy chain V-IIIregion NIE [plasmamembrane]Ig kappa chain V-Iregion WEA [plasmamembrane]Ig kappa chain V-IIregion RPMI 6410[plasma membrane]PIP3 activates AKTsignalingIg kappa chain V-IIIregion HIC [plasmamembrane]IGLC2(?-106) [plasmamembrane]Ig heavy chain V-Iregion EU [plasmamembrane]Ca2+ [cytosol]VAV1 [plasmamembrane]Ig kappa chain Vregion EV15 [plasmamembrane]Ig lambda chain V-Iregion EPS [plasmamembrane]PSMA4 [cytosol]Ig kappa chain V-IIIregion VH [plasmamembrane]Ig heavy chain V-IIregion NEWM [plasmamembrane]MALT1 [plasmamembrane]Ig kappa chain V-IIIregion Ti [plasmamembrane]Ig kappa chain V-Iregion WEA [plasmamembrane]Ig kappa chain V-IIIregion Ti [plasmamembrane]Ig lambda chain V-IIregion NIG-58[plasma membrane]DephosphorylatedNFATC1/2/3Ig lambda chain V-Iregion HA [plasmamembrane]Ig kappa chain V-Iregion Hau [plasmamembrane]ITPR1 [endoplasmicreticulum membrane]Ig heavy chain V-IIIregion GAL [plasmamembrane]IKBKG [plasmamembrane]Ig kappa chain V-IIIregion B6 [plasmamembrane]VAV1 [plasmamembrane]Ig heavy chain V-IIIregion POM [plasmamembrane]Calcineurin:PhosphorylatedNFATC1/2/3Ig kappa chain V-IVregion JI [plasmamembrane]Zn2+ [cytosol]CD19 [plasmamembrane]Ig lambda chain V-Iregion BL2 [plasmamembrane]Ig kappa chain V-Iregion DEE [plasmamembrane]Ig kappa chain V-IIIregion WOL [plasmamembrane]Ig lambda chain V-Iregion MEM [plasmamembrane]PSMC2 [cytosol]Ig kappa chain V-IIIregion NG9 [plasmamembrane]Ig lambda chain V-IIregion NIG-84[plasma membrane]p-BCL10 [plasmamembrane]Ig lambda chain V-VIregion WLT [plasmamembrane]Ig kappa chain V-Iregion OU [plasmamembrane]Ig kappa chain V-Iregion Wes [plasmamembrane]p-Y753,Y759,Y1217-PLCG2[plasma membrane]IGLC1(1-105) [plasmamembrane]Orai1 dimerIGKC(1-106) [plasmamembrane]Ig kappa chain V-IIIregion IARC/BL41[plasma membrane]Ig kappa chain V-Iregion DEE [plasmamembrane]NF-kappaBp50/p65/c-Rel:ub-p-IKBPSMB11 [cytosol]Ig heavy chain V-IIIregion HIL [plasmamembrane]PSMB1 [cytosol]IGKV4-1(21-?)[plasma membrane]Ig kappa chain V-IVregion JI [plasmamembrane]Ig kappa chain V-Iregion EU [plasmamembrane]Ig lambda chain V-Iregion EPS [plasmamembrane]Ig kappa chain V-IIregion Cum [plasmamembrane]Ig kappa chain V-Iregion Gal [plasmamembrane]IGLV(23-?) [plasmamembrane]IGKV4-1(21-?)[plasma membrane]Ig heavy chain V-IIIregion LAY [plasmamembrane]Ig heavy chain V-IIIregion BUR [plasmamembrane]Ig kappa chain V-Iregion Wes [plasmamembrane]Ig heavy chain V-IIIregion CAM [plasmamembrane]Ig kappa chain V-IIIregion IARC/BL41[plasma membrane]SKP1 [cytosol]ITPR2 [endoplasmicreticulum membrane]Ig kappa chain V-Iregion WAT [plasmamembrane]Ig kappa chain V-IIIregion GOL [plasmamembrane]IGLC1(1-105) [plasmamembrane]Ig lambda chain V-IVregion X [plasmamembrane]IGKVA18(21-?)[plasma membrane]Calcineurin (CaN)Ig heavy chain V-IIregion NEWM [plasmamembrane]Ig kappa chain V-IIregion FR [plasmamembrane]Ig lambda chain V-IVregion X [plasmamembrane]Ig kappa chain V-Iregion Ka [plasmamembrane]IGKVA18(21-?)[plasma membrane]Ig kappa chain V-Iregion Ni [plasmamembrane]IGLC3(?-106) [plasmamembrane]Ig kappa chain V-Iregion AU [plasmamembrane]Ig heavy chain V-IIIregion CAM [plasmamembrane]PIK3CD [plasmamembrane]CD79B [plasmamembrane]ADPIGHV7-81(1-?)[plasma membrane]PI(3,4,5)P3ADPMALT1TRPC1ADPIg heavy chain V-IIIregion BUT [plasmamembrane]PLC gamma1/2p21 RAS:GTPIg heavy chain V-IIregion SESS [plasmamembrane]Ig lambda chain V-Iregion WAH [plasmamembrane]Ig lambda chain V-IVregion X [plasmamembrane]p-6Y-SYK [plasmamembrane]Ig heavy chain V-Iregion SIE [plasmamembrane]Ig heavy chain V-IIregion ARH-77[plasma membrane]Ig kappa chain V-IIIregion POM [plasmamembrane]Ig kappa chain V-IIIregion VG [plasmamembrane]Ig kappa chain V-Iregion BAN [plasmamembrane]Ig heavy chain V-IIregion MCE [plasmamembrane]Ca2+ [plasmamembrane]Ig kappa chain V-Iregion Hau [plasmamembrane]Ig kappa chain V-IIIregion Ti [plasmamembrane]Fe3+ [cytosol]Ig heavy chain V-IIregion MCE [plasmamembrane]Ig kappa chain V-IIregion TEW [plasmamembrane]PPP3CA [cytosol]Ig kappa chain V-IIIregion HIC [plasmamembrane]CBLB [plasmamembrane]ATPIg lambda chain V-IIregion TRO [plasmamembrane]Ig heavy chain V-IIregion SESS [plasmamembrane]Ig heavy chain V-Iregion Mot [plasmamembrane]Ig kappa chain V-IIIregion VH [plasmamembrane]Ig kappa chain V-IIregion MIL [plasmamembrane]STIM1 [endoplasmicreticulum membrane]PSMA7(2-248)[cytosol]CALM1 [cytosol]Ig lambda chain V-IIregion VIL [plasmamembrane]Ig lambda chain V-VIregion EB4 [plasmamembrane]ATPCD79A [plasmamembrane]PSMA5 [cytosol]IGKC(1-106) [plasmamembrane]IGKV4-1(21-?)[plasma membrane]IGLC2(?-106) [plasmamembrane]Ig kappa chain V-Iregion Wes [plasmamembrane]Ig lambda chain V-IIregion VIL [plasmamembrane]IGKV4-1(21-?)[plasma membrane]Ig heavy chain V-IIIregion LAY [plasmamembrane]PSMC4 [cytosol]Ig kappa chain V-IIIregion WOL [plasmamembrane]p21 RAS:GDPIg heavy chain V-IIIregion BUT [plasmamembrane]Ig heavy chain V-IIIregion TUR [plasmamembrane]RELA [cytosol]Ig kappa chain V-Iregion EU [plasmamembrane]Ig lambda chain V-VIregion WLT [plasmamembrane]DAGPSMD4(2-377)[cytosol]Ig kappa chain V-Iregion Kue [plasmamembrane]Ig lambda chain V-IIregion BO [plasmamembrane]Ig lambda chain V-IIregion BOH [plasmamembrane]Ig kappa chain V-IIIregion POM [plasmamembrane]Ig kappa chain V-IIregion RPMI 6410[plasma membrane]Ig kappa chain V-IIIregion B6 [plasmamembrane]p-Y188,Y199-CD79A[plasma membrane]Ig heavy chain V-IIIregion KOL [plasmamembrane]IGHM(?-452) [plasmamembrane]p-6Y-CD19 [plasmamembrane]Ig kappa chain V-IIIregion VH [plasmamembrane]Ig kappa chain V-Iregion HK101 [plasmamembrane]REL [nucleoplasm]Ig lambda chain V-IVregion Bau [plasmamembrane]Ig lambda chain V-Iregion VOR [plasmamembrane]Ig lambda chain V-Iregion WAH [plasmamembrane]RasGRP1/3IGLC1(1-105) [plasmamembrane]Ig lambda chain V-IIregion TOG [plasmamembrane]Ig lambda chain V-IIregion MGC [plasmamembrane]Ig kappa chain V-Iregion Wes [plasmamembrane]CD79B [plasmamembrane]Ig kappa chain V-Iregion WAT [plasmamembrane]Ig heavy chain V-IIregion HE [plasmamembrane]Ig heavy chain V-IIregion MCE [plasmamembrane]Ig heavy chain V-IIIregion WAS [plasmamembrane]p-Y196,Y207-CD79B[plasma membrane]Ig kappa chain V-Iregion Ni [plasmamembrane]Ig heavy chain V-IIIregion NIE [plasmamembrane]Ig heavy chain V-IIIregion NIE [plasmamembrane]p-Y188,Y199-CD79A[plasma membrane]Ig lambda chain V-VIregion AR [plasmamembrane]Ig lambda chain V-IIregion NIG-58[plasma membrane]Ig lambda chain V-IIregion VIL [plasmamembrane]REL [cytosol]Ig kappa chain V-IVregion STH [plasmamembrane]Ig heavy chain V-IIIregion GAL [plasmamembrane]Ig lambda chain V-IIregion MGC [plasmamembrane]Ig kappa chain V-Iregion Gal [plasmamembrane]IKBKG [cytosol]Ig lambda chain V-IVregion Bau [plasmamembrane]IGHV7-81(1-?)[plasma membrane]CBL [plasmamembrane]Ig kappa chain V-Iregion Gal [plasmamembrane]Ig heavy chain V-IIIregion LAY [plasmamembrane]ADPp-Y196,Y207-CD79B[plasma membrane]IGLC6(?-106) [plasmamembrane]Ig heavy chain V-IIIregion GAL [plasmamembrane]PPP3CA [cytosol]Ig heavy chain V-IIIregion ZAP [plasmamembrane]Ig kappa chain V-Iregion Bi [plasmamembrane]PSMA6 [cytosol]PSMB2 [cytosol]NF-kappaBp50/p65/c-Rel DimerIg kappa chain V-Iregion Rei [plasmamembrane]p-S559,S644,S652-CARD11(1-1147)[plasma membrane]Ig kappa chain V-Iregion Walker[plasma membrane]Ig kappa chain V-IIIregion CLL [plasmamembrane]Ig kappa chain V-Iregion Lay [plasmamembrane]Ig lambda chain V-IIregion NIG-84[plasma membrane]Ig lambda chain V-IIregion BOH [plasmamembrane]Ig kappa chain V-Iregion Lay [plasmamembrane]AntigenPSMD12 [cytosol]Ca2+ [cytosol]Ig kappa chain V-Iregion Ka [plasmamembrane]IGHD(?-384) [plasmamembrane]Ig heavy chain V-IIregion WAH [plasmamembrane]CyclophilinA:Cyclosporin AIg kappa chain V-IIIregion POM [plasmamembrane]Ig heavy chain V-IIregion COR [plasmamembrane]IKKA:IKKB:NEMOIg kappa chain V-Iregion Daudi [plasmamembrane]Ig kappa chain V-IIIregion B6 [plasmamembrane]Ig lambda chain V-VIregion NIG-48[plasma membrane]Ig lambda chain V-IVregion MOL [plasmamembrane]Ig kappa chain V-IIIregion VG [plasmamembrane]Ig heavy chain V-IIIregion GA [plasmamembrane]CALM1Ig lambda chain V-VIregion NIG-48[plasma membrane]Ig kappa chain V-IIIregion Ti [plasmamembrane]Ig heavy chain V-Iregion SIE [plasmamembrane]Ig heavy chain V-Iregion WOL [plasmamembrane]IGLC2(?-106) [plasmamembrane]PSMD13 [cytosol]p-BCL10 [plasmamembrane]Ig kappa chain V-IIregion MIL [plasmamembrane]Ig heavy chain V-IIIregion NIE [plasmamembrane]p-Y196,Y207-CD79B[plasma membrane]IGKC(1-106) [plasmamembrane]Ig kappa chain V-Iregion CAR [plasmamembrane]IGHV7-81(1-?)[plasma membrane]Ig lambda chain V-IVregion Hil [plasmamembrane]Ig lambda chain V-VIregion AR [plasmamembrane]Ig lambda chainV-III region LOI[plasma membrane]Tacrolimus [cytosol]Ig lambda chain V-IIregion BOH [plasmamembrane]Zn2+ [cytosol]Ig heavy chain V-Iregion ND [plasmamembrane]PSMD8 [cytosol]Ig kappa chain V-IIregion GM607 [plasmamembrane]Ig heavy chain V-IIIregion GA [plasmamembrane]Ig lambda chain V-Iregion EPS [plasmamembrane]Ig kappa chain V-Iregion Roy [plasmamembrane]Ig kappa chain V-IIregion FR [plasmamembrane]Ig kappa chain V-Iregion Mev [plasmamembrane]Ig kappa chain V-Iregion WEA [plasmamembrane]Ig heavy chain V-IIregion ARH-77[plasma membrane]Ig heavy chain V-IIregion DAW [plasmamembrane]SH3KBP1 [plasmamembrane]Ig lambda chain V-VIregion EB4 [plasmamembrane]IGHM(?-452) [plasmamembrane]Ig kappa chain V-Iregion HK101 [plasmamembrane]Ig lambda chain V-IVregion Hil [plasmamembrane]PSMD9 [cytosol]Active CalmodulinIg kappa chain V-IIIregion HIC [plasmamembrane]IKBKB [plasmamembrane]Ig lambda chain V-VIregion EB4 [plasmamembrane]Ig lambda chain V-Iregion NEWM [plasmamembrane]IKBKB [cytosol]Ig lambda chain V-VIregion AR [plasmamembrane]Ig lambda chain V-VIregion EB4 [plasmamembrane]Ig kappa chain V-IIIregion VG [plasmamembrane]Ig heavy chain V-Iregion HG3 [plasmamembrane]IgH heavy chainV-III region VH26precursor [plasmamembrane]Ig lambda chain V-Iregion VOR [plasmamembrane]Ig lambda chain V-IIregion WIN [plasmamembrane]Ig heavy chain V-IIIregion CAM [plasmamembrane]IGHV(1-?) [plasmamembrane]Ig kappa chain V-Iregion HK101 [plasmamembrane]Ig lambda chain V-IIregion MGC [plasmamembrane]BTRC [cytosol]Ig kappa chain V-IIregion TEW [plasmamembrane]p-BCL10 [plasmamembrane]PSMF1(2-271)[cytosol]Ig kappa chain V-IIIregion VH [plasmamembrane]FBXW11 [cytosol]Ig kappa chain V-IVregion Len [plasmamembrane]Ig lambda chain V-Vregion DEL [plasmamembrane]Ig heavy chain V-IIIregion GAL [plasmamembrane]Ig heavy chain V-IIIregion JON [plasmamembrane]Ig heavy chain V-IIIregion CAM [plasmamembrane]Ig kappa chain V-Iregion WAT [plasmamembrane]NFKBIB [cytosol]Antigen:p-BCR:SYKIg heavy chain V-IIregion ARH-77[plasma membrane]Ig heavy chain V-IIIregion POM [plasmamembrane]SH3KBP1 [cytosol]Ig kappa chain V-IIIregion POM [plasmamembrane]Ig kappa chain V-Iregion Gal [plasmamembrane]PSMD2 [cytosol]Ig heavy chain V-IIIregion WAS [plasmamembrane]Ig kappa chain V-Iregion Mev [plasmamembrane]Ig kappa chain V-Iregion Bi [plasmamembrane]Ig kappa chain V-Iregion BAN [plasmamembrane]Ig kappa chain V-Iregion Rei [plasmamembrane]Ca2+ [endoplasmicreticulum lumen]Ig lambda chain V-IVregion Bau [plasmamembrane]CBL [cytosol]Ig heavy chain V-IIIregion DOB [plasmamembrane]Ig heavy chain V-IIIregion BRO [plasmamembrane]IGHD(?-384) [plasmamembrane]Ig heavy chain V-IIIregion TUR [plasmamembrane]Ig lambda chain V-Iregion MEM [plasmamembrane]Ig lambda chain V-IVregion MOL [plasmamembrane]Ig kappa chain V-Iregion Bi [plasmamembrane]Ig lambda chain V-IIregion VIL [plasmamembrane]Ig lambda chainV-III region SH[plasma membrane]Ig kappa chain V-IIregion MIL [plasmamembrane]Ig kappa chain V-Iregion Roy [plasmamembrane]Ig kappa chain V-Iregion AU [plasmamembrane]Ig kappa chain Vregion EV15 [plasmamembrane]Ig heavy chain V-IIIregion DOB [plasmamembrane]Ig heavy chain V-IIIregion HIL [plasmamembrane]NFKB1(1-433)[nucleoplasm]p-CARMA1 OligomerCD19:VAV1Ig heavy chain V-Iregion WOL [plasmamembrane]Ig lambda chainV-VII region MOT[plasma membrane]Ig kappa chain V-IIregion TEW [plasmamembrane]Ig heavy chain V-IIIregion WAS [plasmamembrane]Ig heavy chain V-Iregion ND [plasmamembrane]Ig kappa chain V-Iregion CAR [plasmamembrane]Ig heavy chain V-IIIregion GAL [plasmamembrane]Ig lambda chain V-Iregion VOR [plasmamembrane]Ig heavy chain V-IIIregion BRO [plasmamembrane]Ig kappa chain V-IVregion Len [plasmamembrane]Ig heavy chain V-IIIregion ZAP [plasmamembrane]Ig heavy chain V-IIIregion WEA [plasmamembrane]Ig lambda chain V-Iregion BL2 [plasmamembrane]Ig kappa chain V-Iregion EU [plasmamembrane]Ig heavy chain V-IIIregion TUR [plasmamembrane]Ig kappa chain V-Iregion AU [plasmamembrane]IGLC7(?-106) [plasmamembrane]p-T187-MAP3K7[plasma membrane]p-14S-NFATC2[cytosol]Ig kappa chain V-Iregion Mev [plasmamembrane]Ig kappa chain V-Iregion Scw [plasmamembrane]Ig heavy chain V-Iregion HG3 [plasmamembrane]Ig lambda chain V-IIregion BUR [plasmamembrane]Ig lambda chain V-IIregion NIG-84[plasma membrane]p-T187-MAP3K7[plasma membrane]Ig kappa chain V-IIregion FR [plasmamembrane]Ig kappa chain V-Iregion Gal [plasmamembrane]PSMB5 [cytosol]p-Y188,Y199-CD79A[plasma membrane]Ig kappa chain V-Iregion Lay [plasmamembrane]STIM1 [endoplasmicreticulum membrane]Ig lambda chain V-IIregion WIN [plasmamembrane]Ig lambda chain V-IIregion TOG [plasmamembrane]Ig heavy chain V-IIregion DAW [plasmamembrane]Ig heavy chain V-IIregion WAH [plasmamembrane]p-12S-NFATC1[cytosol]IGHV(1-?) [plasmamembrane]Ig lambda chain V-IVregion MOL [plasmamembrane]IGKV4-1(21-?)[plasma membrane]Ig lambda chain Vregion 4A [plasmamembrane]Ig kappa chain V-Iregion Kue [plasmamembrane]NFKB1(1-433)[cytosol]Ig lambda chain V-Iregion NEWM [plasmamembrane]PIK3CD [cytosol]Ig lambda chain V-IIregion TRO [plasmamembrane]IGLC3(?-106) [plasmamembrane]Ig lambda chain V-IIregion BUR [plasmamembrane]IGHM(?-452) [plasmamembrane]Ig kappa chain V-IIregion Cum [plasmamembrane]Ig kappa chain V-IIIregion NG9 [plasmamembrane]p-S559,S644,S652-CARD11(1-1147)[plasma membrane]PSMD1 [cytosol]Ig heavy chain V-IIIregion NIE [plasmamembrane]Ig lambda chain V-Iregion NEW [plasmamembrane]Ig heavy chain V-Iregion Mot [plasmamembrane]Ig kappa chain V-Iregion HK101 [plasmamembrane]PI(4,5)P2Ig heavy chain V-IIIregion BRO [plasmamembrane]Ig heavy chain V-Iregion Mot [plasmamembrane]IGHD(?-384) [plasmamembrane]IGKV1-5(23-?)[plasma membrane]Ig kappa chain V-IIIregion HAH [plasmamembrane]Ig kappa chain V-IIregion RPMI 6410[plasma membrane]CARMA1:BCL10:MALT1:TAK1Ig lambda chain V-IIregion WIN [plasmamembrane]Ig lambda chain V-IIregion NIG-58[plasma membrane]PSMA2 [cytosol]IGLC3(?-106) [plasmamembrane]Ig heavy chain V-IIIregion TEI [plasmamembrane]p-RasGRP1,3:DAGIGLC6(?-106) [plasmamembrane]Antigen:BCRIg lambda chain V-Iregion NEW [plasmamembrane]ADPIg kappa chain V-IIIregion HIC [plasmamembrane]Ig heavy chain V-IIregion ARH-77[plasma membrane]Ig lambda chain V-IIregion BO [plasmamembrane]Ig kappa chain V-Iregion Gal [plasmamembrane]NFKBIE [cytosol]IGHM(?-452) [plasmamembrane]Ig kappa chain V-Iregion Lay [plasmamembrane]Ig kappa chain V-Iregion CAR [plasmamembrane]FYN(2-537)Ig lambda chain V-IVregion Bau [plasmamembrane]PRKCBIGLV(23-?) [plasmamembrane]Ig kappa chain V-Iregion OU [plasmamembrane]Ig kappa chain V-IIIregion NG9 [plasmamembrane]Ig kappa chain V-IIregion Cum [plasmamembrane]Ig heavy chain V-IIIregion DOB [plasmamembrane]IGKVA18(21-?)[plasma membrane]Ig lambda chain V-IVregion Kern [plasmamembrane]PPIA [cytosol]Ig lambda chainV-III region SH[plasma membrane]Ig lambda chain V-Vregion DEL [plasmamembrane]Ig heavy chain V-IIIregion JON [plasmamembrane]Ig heavy chain V-IIIregion WEA [plasmamembrane]Ig kappa chain V-Iregion Roy [plasmamembrane]Ig heavy chain V-IIIregion TEI [plasmamembrane]Ig lambda chain V-VIregion SUT [plasmamembrane]ITPR1 [endoplasmicreticulum membrane]Ig lambda chain V-Iregion WAH [plasmamembrane]IGHV(1-?) [plasmamembrane]Ig heavy chain V-IIIregion WAS [plasmamembrane]RELA [cytosol]Ig lambda chain V-Iregion NIG-64[plasma membrane]I(1,4,5)P3Ig lambda chainV-VII region MOT[plasma membrane]Ig lambda chain V-VIregion SUT [plasmamembrane]Ig heavy chain V-Iregion WOL [plasmamembrane]Ig heavy chain V-IIregion COR [plasmamembrane]Ig lambda chain V-Vregion DEL [plasmamembrane]Ig lambda chain V-IIregion NIG-84[plasma membrane]Ig kappa chain V-IIregion RPMI 6410[plasma membrane]PSMD6(2-389)[cytosol]Ig lambda chain V-Vregion DEL [plasmamembrane]Ig kappa chain V-Iregion OU [plasmamembrane]PSMA8 [cytosol]Ig kappa chain V-Iregion Rei [plasmamembrane]Ig kappa chain V-Iregion AG [plasmamembrane]IKBKG [cytosol]Ig kappa chain V-Iregion Kue [plasmamembrane]Ig kappa chain V-IIIregion Ti [plasmamembrane]Ig kappa chain V-Iregion Rei [plasmamembrane]Ig heavy chain V-IIregion OU [plasmamembrane]Ig kappa chain V-IVregion STH [plasmamembrane]Ig kappa chain V-Iregion Lay [plasmamembrane]Ig lambda chain V-IIregion BOH [plasmamembrane]Ig lambda chain V-IIregion TOG [plasmamembrane]CRAC channelIg heavy chain V-IIregion OU [plasmamembrane]CHUK [plasmamembrane]Ig heavy chain V-IIregion NEWM [plasmamembrane]Ig heavy chain V-Iregion ND [plasmamembrane]Ig kappa chain V-Iregion Ka [plasmamembrane]p-S19,S23-NFKBIB[cytosol]Ig heavy chain V-IIIregion BRO [plasmamembrane]Ig kappa chain V-Iregion DEE [plasmamembrane]Ig lambda chain V-Iregion NEW [plasmamembrane]Ig kappa chain V-IVregion STH [plasmamembrane]Ig kappa chain V-Iregion Lay [plasmamembrane]SYK [plasmamembrane]IGLC7(?-106) [plasmamembrane]RELA [nucleoplasm]Ig heavy chain V-IIIregion WEA [plasmamembrane]Ig kappa chain V-IIregion TEW [plasmamembrane]PRKCB [plasmamembrane]Ig kappa chain V-IIIregion POM [plasmamembrane]Ig kappa chain V-IIIregion HAH [plasmamembrane]Ig lambda chain V-IVregion Hil [plasmamembrane]IGLC2(?-106) [plasmamembrane]Ig heavy chain V-IIIregion BUR [plasmamembrane]Ig heavy chain V-IIIregion POM [plasmamembrane]CARD11(1-1147)[cytosol]Ig kappa chain V-Iregion Lay [plasmamembrane]IP3 receptorhomotetramerIg heavy chain V-IIregion HE [plasmamembrane]Ig heavy chain V-IIIregion LAY [plasmamembrane]BLK(2-505)Ig kappa chain V-Iregion Ni [plasmamembrane]Ig kappa chain V-Iregion Wes [plasmamembrane]Ig kappa chain V-IIIregion WOL [plasmamembrane]Ig kappa chain V-IVregion B17 [plasmamembrane]Ig heavy chain V-Iregion SIE [plasmamembrane]Ig heavy chain V-Iregion Mot [plasmamembrane]PIK3AP1Ig kappa chain V-IIIregion HIC [plasmamembrane]Ig kappa chain V-IVregion B17 [plasmamembrane]IGHV7-81(1-?)[plasma membrane]Ig lambda chain V-VIregion EB4 [plasmamembrane]Ca2+Ig kappa chain V-IIIregion HIC [plasmamembrane]SCF-beta-TrCp1/2p-Y771,Y783-PLCG1[plasma membrane]Ig kappa chain V-Iregion AU [plasmamembrane]RELA [cytosol]Ig kappa chain V-IVregion B17 [plasmamembrane]PSMB8 [cytosol]Ig kappa chain V-Iregion DEE [plasmamembrane]Ig heavy chain V-IIregion DAW [plasmamembrane]GDP [cytosol]IgH heavy chainV-III region VH26precursor [plasmamembrane]Ig kappa chain V-IVregion STH [plasmamembrane]IP3 receptor:IP3complexIg kappa chain V-IIregion RPMI 6410[plasma membrane]SYKIg kappa chain V-IIIregion VG [plasmamembrane]Ig lambda chain V-Iregion HA [plasmamembrane]Ig lambda chain V-IIregion TRO [plasmamembrane]Ig heavy chain V-Iregion Mot [plasmamembrane]Ig heavy chain V-IIregion DAW [plasmamembrane]STIM1 [endoplasmicreticulum membrane]Ig kappa chain V-Iregion Kue [plasmamembrane]Ig heavy chain V-IIIregion JON [plasmamembrane]Ig lambda chain V-IIregion NIG-58[plasma membrane]Ig heavy chain V-IIregion SESS [plasmamembrane]Ig lambda chain V-IIregion BOH [plasmamembrane]Ig heavy chain V-IIregion HE [plasmamembrane]Ig heavy chain V-IIIregion JON [plasmamembrane]Phosphatidylserine[plasma membrane]NFKB1(1-433)[cytosol]Ig heavy chain V-IIregion WAH [plasmamembrane]Ig heavy chain V-IIregion DAW [plasmamembrane]Ig heavy chain V-IIIregion ZAP [plasmamembrane]Ig kappa chain V-Iregion Scw [plasmamembrane]STIM1:CalciumIg lambda chain V-IIregion TOG [plasmamembrane]PSMA3 [cytosol]Ig kappa chain V-IIIregion CLL [plasmamembrane]Ig heavy chain V-Iregion HG3 [plasmamembrane]IGKVA18(21-?)[plasma membrane]Ca2+IGLV(23-?) [plasmamembrane]Ig kappa chain V-IIIregion SIE [plasmamembrane]Ig kappa chain V-IIIregion IARC/BL41[plasma membrane]Ig lambda chain Vregion 4A [plasmamembrane]IGKV4-1(21-?)[plasma membrane]Ig kappa chain V-Iregion WAT [plasmamembrane]Ig heavy chain V-IIIregion POM [plasmamembrane]Ig heavy chain V-IIIregion ZAP [plasmamembrane]Ig kappa chain V-IVregion STH [plasmamembrane]Ig kappa chain V-Iregion Scw [plasmamembrane]NF-kappaBp50/p65/c-Rel DimerIg kappa chain V-IIregion MIL [plasmamembrane]Ig heavy chain V-IIIregion CAM [plasmamembrane]Ig lambda chain V-IIregion BO [plasmamembrane]Ig kappa chain V-Iregion Scw [plasmamembrane]Ig kappa chain V-IIregion TEW [plasmamembrane]Ig heavy chain V-IIIregion POM [plasmamembrane]IgH heavy chainV-III region VH26precursor [plasmamembrane]Ig kappa chain V-IVregion Len [plasmamembrane]Ig lambda chainV-VII region MOT[plasma membrane]Ig kappa chain V-Iregion Daudi [plasmamembrane]Ig kappa chain V-Iregion OU [plasmamembrane]PSME4 [cytosol]Ig kappa chain V-IIIregion HAH [plasmamembrane]Ig lambda chain V-Iregion VOR [plasmamembrane]Ig heavy chain V-IIIregion TRO [plasmamembrane]Ig lambda chain V-VIregion NIG-48[plasma membrane]CBLB [plasmamembrane]Ig lambda chain V-IIregion MGC [plasmamembrane]Ig kappa chain V-IIIregion WOL [plasmamembrane]Cyclosporin A[cytosol]Ig heavy chain V-IIIregion WEA [plasmamembrane]Ig heavy chain V-IIIregion BUR [plasmamembrane]p-S157,S161-NFKBIE[cytosol]Ig kappa chain V-IIIregion CLL [plasmamembrane]Ig heavy chain V-IIregion HE [plasmamembrane]p-13S-NFATC3[cytosol]Ig lambda chainV-III region SH[plasma membrane]IGHM(?-452) [plasmamembrane]Ig kappa chain V-IVregion Len [plasmamembrane]Ig lambda chain V-Iregion NIG-64[plasma membrane]PSMD10 [cytosol]Ig heavy chain V-IIIregion TEI [plasmamembrane]IGLC7(?-106) [plasmamembrane]PI(4,5)P2p-T133-RASGRP3[plasma membrane]PSMB10 [cytosol]Ig kappa chain Vregion EV15 [plasmamembrane]Ig heavy chain V-IIIregion KOL [plasmamembrane]Ig kappa chain V-IVregion B17 [plasmamembrane]p-T184-RASGRP1[plasma membrane]Ig kappa chain V-IIIregion Ti [plasmamembrane]Ig heavy chain V-IIIregion HIL [plasmamembrane]PIK3R1 [plasmamembrane]Antigen:p-BCR:p-SYK:p-BLNKADPIg heavy chain V-IIIregion TEI [plasmamembrane]Ig lambda chain V-Iregion BL2 [plasmamembrane]p-S177,S181-IKBKB[cytosol]Ig kappa chain V-IIregion MIL [plasmamembrane]p-S157,S161-NFKBIE[cytosol]Ig lambda chain V-IVregion X [plasmamembrane]CHUK [cytosol]SH3KBP1 [plasmamembrane]IGHD(?-384) [plasmamembrane]p-S19,S23-Ub-NFKBIB[cytosol]BTKIg lambda chain V-Iregion NEWM [plasmamembrane]Ig kappa chain V-IIIregion NG9 [plasmamembrane]Ig kappa chain V-IIIregion GOL [plasmamembrane]IGLC2(?-106) [plasmamembrane]Ig lambda chain V-IIregion NIG-84[plasma membrane]Ig kappa chain V-Iregion Mev [plasmamembrane]Ig lambda chain Vregion 4A [plasmamembrane]GRB2-1 [cytosol]Ig kappa chain V-IIregion GM607 [plasmamembrane]Ig heavy chain V-IIIregion TIL [plasmamembrane]Ig kappa chain V-Iregion Bi [plasmamembrane]IGHV7-81(1-?)[plasma membrane]Ig kappa chain V-Iregion OU [plasmamembrane]Ig lambda chain V-Iregion NIG-64[plasma membrane]Ig lambda chain V-Iregion MEM [plasmamembrane]ORAI1 [plasmamembrane]IGLC6(?-106) [plasmamembrane]GTP [cytosol]Ig heavy chain V-IIIregion TRO [plasmamembrane]IGKC(1-106) [plasmamembrane]p-4Y-PIK3AP1 [plasmamembrane]VAV1 [plasmamembrane]IGLC6(?-106) [plasmamembrane]Ig kappa chain V-IVregion JI [plasmamembrane]Ig heavy chain V-IIregion HE [plasmamembrane]Ig heavy chain V-Iregion SIE [plasmamembrane]PSMC1(2-440)[cytosol]Ig lambda chain V-VIregion WLT [plasmamembrane]Ig lambda chain V-IIregion NIG-58[plasma membrane]Ig lambda chain V-IVregion Hil [plasmamembrane]IGLV(23-?) [plasmamembrane]Ca2+IGLV(23-?) [plasmamembrane]Ig kappa chain V-Iregion OU [plasmamembrane]Ig kappa chain V-Iregion Ka [plasmamembrane]Ig kappa chain V-IIIregion Ti [plasmamembrane]Ig kappa chain V-Iregion Hau [plasmamembrane]PSMC6(2-389)[cytosol]Ig heavy chain V-IIIregion BUR [plasmamembrane]Ig kappa chain V-IIregion GM607 [plasmamembrane]Ig lambda chain V-VIregion EB4 [plasmamembrane]Ig lambda chain V-Iregion WAH [plasmamembrane]Ig heavy chain V-IIregion NEWM [plasmamembrane]Ig kappa chain V-Iregion CAR [plasmamembrane]Ig heavy chain V-IIIregion TUR [plasmamembrane]PSME1 [cytosol]IGKVA18(21-?)[plasma membrane]Ig kappa chain V-IIIregion VG [plasmamembrane]Ig lambda chain V-IIregion BO [plasmamembrane]Ig lambda chain V-VIregion AR [plasmamembrane]IGHV(1-?) [plasmamembrane]CD79A [plasmamembrane]Ig heavy chain V-IIregion NEWM [plasmamembrane]Ig lambda chain V-VIregion NIG-48[plasma membrane]IGHM(?-452) [plasmamembrane]Ig kappa chain Vregion EV15 [plasmamembrane]p-BCL10Ig lambda chainV-III region SH[plasma membrane]Ig heavy chain V-IIIregion TEI [plasmamembrane]p-S157,S161-Ub-NFKBIE[cytosol]Ig lambda chain V-Iregion NIG-64[plasma membrane]Ig kappa chain V-IIIregion CLL [plasmamembrane]Ig kappa chain V-Iregion Mev [plasmamembrane]ITPR2 [endoplasmicreticulum membrane]IGHV7-81(1-?)[plasma membrane]MALT1 [plasmamembrane]Ig lambda chainV-VII region MOT[plasma membrane]PSMA1 [cytosol]Ig kappa chain V-Iregion Daudi [plasmamembrane]PIK3CD:PIK3R1Ig heavy chain V-Iregion ND [plasmamembrane]Ig lambda chain V-Iregion WAH [plasmamembrane]GRB2-1 [plasmamembrane]CD19 SignalosomeIg lambda chain V-IVregion Kern [plasmamembrane]Ig kappa chain V-IIIregion GOL [plasmamembrane]Ig kappa chain V-IIIregion NG9 [plasmamembrane]PIK3R1 [plasmamembrane]Ig lambda chain V-VIregion AR [plasmamembrane]RELA [cytosol]Ig heavy chain V-Iregion EU [plasmamembrane]Ig kappa chain V-Iregion Hau [plasmamembrane]Ig lambda chain V-IIregion VIL [plasmamembrane]DAG [plasmamembrane]Ig lambda chain V-IIregion BUR [plasmamembrane]p-Y188,Y199-CD79A[plasma membrane]Ig lambda chain V-IIregion NEI [plasmamembrane]Ig kappa chain Vregion EV15 [plasmamembrane]ORAI1 [plasmamembrane]Ig lambda chain V-Iregion MEM [plasmamembrane]Ig kappa chain V-Iregion BAN [plasmamembrane]NF-kappa-B p50/p65/c-Rel:p-IKBIg kappa chain V-IIIregion GOL [plasmamembrane]Ig kappa chain V-IIregion GM607 [plasmamembrane]IGLC7(?-106) [plasmamembrane]NFKBIA [cytosol]Ig kappa chain V-IIIregion IARC/BL41[plasma membrane]IGLC7(?-106) [plasmamembrane]Ig kappa chain V-Iregion Walker[plasma membrane]Ig lambda chain V-IIregion BO [plasmamembrane]PSME3 [cytosol]Ig lambda chain V-IVregion X [plasmamembrane]26S proteasomeBLNK (SLP-65)SignalosomeHRAS(1-186) [plasmamembrane]REL [cytosol]Ig lambda chain V-IIregion MGC [plasmamembrane]Ig lambda chain V-VIregion WLT [plasmamembrane]PIK3CD:PIK3R1Ig kappa chain V-IIregion GM607 [plasmamembrane]Ig lambda chain V-Iregion EPS [plasmamembrane]Ig heavy chain V-IIIregion LAY [plasmamembrane]NRAS [plasmamembrane]Ig kappa chain V-IIIregion GOL [plasmamembrane]Ig lambda chain V-IVregion MOL [plasmamembrane]Ig kappa chain V-IIIregion GOL [plasmamembrane]Ig kappa chain V-Iregion Kue [plasmamembrane]PhosphorylatedNFATC1/2/3Ig kappa chain V-Iregion Walker[plasma membrane]Ig lambda chain V-IIregion VIL [plasmamembrane]IGLV(23-?) [plasmamembrane]Ig kappa chain V-IIIregion WOL [plasmamembrane]PI(4,5)P2Ig heavy chain V-IIIregion GA [plasmamembrane]Ig lambda chain V-VIregion SUT [plasmamembrane]IGLC1(1-105) [plasmamembrane]Ig heavy chain V-Iregion Mot [plasmamembrane]CARMA1:MALT1:BCL10Ig heavy chain V-IIIregion HIL [plasmamembrane]Antigen:p-BCR:p-SYKIg kappa chain V-Iregion Ni [plasmamembrane]Ig heavy chain V-IIIregion WEA [plasmamembrane]Ig kappa chain V-IIIregion IARC/BL41[plasma membrane]Ig heavy chain V-IIregion MCE [plasmamembrane]BLNK:GRB2:SOS1:CIN85:CBLIg heavy chain V-Iregion HG3 [plasmamembrane]Ig kappa chain V-Iregion Ka [plasmamembrane]Ig lambda chain V-IIregion WIN [plasmamembrane]p-Y196,Y207-CD79B[plasma membrane]p-5Y-BLNK [plasmamembrane]Ig kappa chain V-IVregion Len [plasmamembrane]UbIg heavy chain V-IIregion SESS [plasmamembrane]p-Y188,Y199-CD79A[plasma membrane]Ig heavy chain V-IIregion HE [plasmamembrane]Ig lambda chain V-IIregion BUR [plasmamembrane]Ig heavy chain V-IIIregion WEA [plasmamembrane]IGLC6(?-106) [plasmamembrane]IGKV1-5(23-?)[plasma membrane]Ig lambda chain V-Vregion DEL [plasmamembrane]CHUK [cytosol]Ig kappa chain V-Iregion WAT [plasmamembrane]Ig kappa chain V-Iregion Wes [plasmamembrane]Ig lambda chain V-VIregion SUT [plasmamembrane]Ig kappa chain V-IIIregion IARC/BL41[plasma membrane]Ig heavy chain V-IIregion WAH [plasmamembrane]IGLC1(1-105) [plasmamembrane]Ig kappa chain V-IIIregion POM [plasmamembrane]PIK3R1 [cytosol]Ig lambda chain V-Iregion NEW [plasmamembrane]Ig kappa chain V-Iregion EU [plasmamembrane]Ig kappa chain V-Iregion AG [plasmamembrane]Ig heavy chain V-IIIregion TUR [plasmamembrane]Ig lambda chain V-VIregion NIG-48[plasma membrane]IgH heavy chainV-III region VH26precursor [plasmamembrane]Ig lambda chain Vregion 4A [plasmamembrane]Ig kappa chain V-IIIregion B6 [plasmamembrane]Ig kappa chain V-IIIregion NG9 [plasmamembrane]Ig heavy chain V-Iregion SIE [plasmamembrane]SOS1 [cytosol]Ig heavy chain V-IIregion ARH-77[plasma membrane]Ig kappa chain V-Iregion Hau [plasmamembrane]Ig heavy chain V-IIIregion GAL [plasmamembrane]Ig heavy chain V-IIIregion TRO [plasmamembrane]IGLC2(?-106) [plasmamembrane]Ig kappa chain V-IIIregion HAH [plasmamembrane]Ig lambda chain V-Iregion BL2 [plasmamembrane]Ig heavy chain V-IIIregion BUT [plasmamembrane]Ig kappa chain V-Iregion WEA [plasmamembrane]Ig lambda chain V-IIregion NEI [plasmamembrane]p-Y223,Y551-BTK[plasma membrane]Ig kappa chain V-Iregion WEA [plasmamembrane]IGKVA18(21-?)[plasma membrane]IGLC7(?-106) [plasmamembrane]Ig kappa chain V-IIIregion VH [plasmamembrane]DAPP1Ig kappa chain V-IIIregion B6 [plasmamembrane]Ig kappa chain V-Iregion DEE [plasmamembrane]Ig heavy chain V-Iregion HG3 [plasmamembrane]Ig kappa chain V-IIregion Cum [plasmamembrane]Antigen:p-BCRIg lambda chain Vregion 4A [plasmamembrane]Ig lambda chain V-VIregion NIG-48[plasma membrane]IGHD(?-384) [plasmamembrane]Ig heavy chain V-IIregion WAH [plasmamembrane]Ig kappa chain V-Iregion Scw [plasmamembrane]IGLC3(?-106) [plasmamembrane]IGKV1-5(23-?)[plasma membrane]Ig lambda chain V-IIregion NIG-58[plasma membrane]p-S559,S644,S652-CARD11(1-1147)[plasma membrane]CBLB [cytosol]ITPR3 [endoplasmicreticulum membrane]Ub-21,22-p-S32,S36-NFKBIA[cytosol]Ig lambda chain V-VIregion SUT [plasmamembrane]IGLC7(?-106) [plasmamembrane]IGHV(1-?) [plasmamembrane]Ig heavy chain V-IIregion WAH [plasmamembrane]Ig heavy chain V-IIregion OU [plasmamembrane]Ig kappa chain V-Iregion EU [plasmamembrane]Ig kappa chain V-IIIregion SIE [plasmamembrane]Ig lambda chain V-IIregion BO [plasmamembrane]Ig heavy chain V-IIIregion DOB [plasmamembrane]Ig lambda chainV-III region SH[plasma membrane]Ig kappa chain V-IIIregion SIE [plasmamembrane]Ig kappa chain V-Iregion HK101 [plasmamembrane]Ig heavy chain V-IIIregion KOL [plasmamembrane]Ig kappa chain V-Iregion Mev [plasmamembrane]BTRC [cytosol]PSMC5 [cytosol]Ig lambda chain V-Iregion NIG-64[plasma membrane]SKP1 [cytosol]Ig lambda chain V-IIregion BUR [plasmamembrane]Ig kappa chain V-Iregion Roy [plasmamembrane]Ig lambda chain V-IIregion NIG-84[plasma membrane]STIM1:TRPC1Ig lambda chain V-IIregion TOG [plasmamembrane]Ig kappa chain V-IIregion Cum [plasmamembrane]Ig lambda chain V-Iregion NEWM [plasmamembrane]Ig lambda chainV-III region LOI[plasma membrane]Ig kappa chain V-Iregion CAR [plasmamembrane]Ig lambda chain V-Iregion NIG-64[plasma membrane]Ig lambda chain V-IIregion TRO [plasmamembrane]PSMD11 [cytosol]Ig heavy chain V-IIregion SESS [plasmamembrane]Ig lambda chain V-Iregion NEW [plasmamembrane]CUL1 [cytosol]IGLV(23-?) [plasmamembrane]PPP3R1 [cytosol]Ig heavy chain V-Iregion EU [plasmamembrane]Ig lambda chain V-Iregion MEM [plasmamembrane]Ig kappa chain V-IIregion RPMI 6410[plasma membrane]Ig heavy chain V-IIIregion JON [plasmamembrane]Ig lambda chain V-Iregion HA [plasmamembrane]Ig lambda chain V-IVregion Kern [plasmamembrane]Ig kappa chain V-IIIregion HAH [plasmamembrane]Ig heavy chain V-IIIregion TUR [plasmamembrane]Ig lambda chainV-III region SH[plasma membrane]IGHV7-81(1-?)[plasma membrane]Ig heavy chain V-IIIregion BRO [plasmamembrane]Ig lambda chain V-Iregion HA [plasmamembrane]NFKB1(1-433)[cytosol]FKBP1A [cytosol]Ig kappa chain V-IIIregion CLL [plasmamembrane]Ig heavy chain V-Iregion EU [plasmamembrane]Ig lambda chain V-IIregion BO [plasmamembrane]Ig kappa chain V-IVregion B17 [plasmamembrane]PPP3R1 [cytosol]Ig lambda chain V-IIregion WIN [plasmamembrane]Ig kappa chain V-Iregion Daudi [plasmamembrane]BCRIg lambda chain V-IIregion NEI [plasmamembrane]p-Y196,Y207-CD79B[plasma membrane]Ig lambda chain V-Iregion BL2 [plasmamembrane]Ig kappa chain V-Iregion Wes [plasmamembrane]IGLC1(1-105) [plasmamembrane]Ig lambda chain V-IIregion TRO [plasmamembrane]Ig heavy chain V-IIIregion DOB [plasmamembrane]Ig kappa chain V-Iregion OU [plasmamembrane]Ig lambda chain V-IIregion VIL [plasmamembrane]Ig kappa chain Vregion EV15 [plasmamembrane]Ig lambda chain V-Iregion EPS [plasmamembrane]Ig kappa chain V-Iregion Scw [plasmamembrane]Ig kappa chain Vregion EV15 [plasmamembrane]Ig heavy chain V-IIregion SESS [plasmamembrane]Ig lambda chain V-IIregion MGC [plasmamembrane]Ig lambda chain V-IVregion Hil [plasmamembrane]Ig heavy chain V-IIregion COR [plasmamembrane]NF-kappa-Bp50,/p65,/c-Rel:IKBIg kappa chain V-IIIregion HAH [plasmamembrane]Ig heavy chain V-Iregion EU [plasmamembrane]PSMD3 [cytosol]Ig lambda chain V-IVregion MOL [plasmamembrane]Ig heavy chain V-IIIregion HIL [plasmamembrane]Ig lambda chainV-III region LOI[plasma membrane]Ig kappa chain V-Iregion WAT [plasmamembrane]Ig lambda chain V-IVregion X [plasmamembrane]ATPNRAS [plasmamembrane]MALT1 [plasmamembrane]Ig kappa chain V-IVregion B17 [plasmamembrane]IGLC3(?-106) [plasmamembrane]Ig kappa chain V-IIIregion HIC [plasmamembrane]Ig heavy chain V-IIIregion ZAP [plasmamembrane]Ig lambda chain V-Iregion VOR [plasmamembrane]Ig heavy chain V-IIregion MCE [plasmamembrane]Ig lambda chain V-Iregion MEM [plasmamembrane]Ig lambda chain V-VIregion SUT [plasmamembrane]Ig heavy chain V-IIIregion TRO [plasmamembrane]Ig kappa chain V-IVregion STH [plasmamembrane]Ig lambda chain V-IVregion Kern [plasmamembrane]STIM1 DimerIg heavy chain V-IIregion MCE [plasmamembrane]Ig heavy chain V-Iregion Mot [plasmamembrane]Ig lambda chain V-Iregion VOR [plasmamembrane]Ig lambda chain V-Iregion NEWM [plasmamembrane]Ig kappa chain V-IIIregion SIE [plasmamembrane]Ig lambda chainV-VII region MOT[plasma membrane]Ig kappa chain V-Iregion WAT [plasmamembrane]Ig kappa chain V-Iregion AG [plasmamembrane]Ig heavy chain V-IIIregion ZAP [plasmamembrane]Ig heavy chain V-Iregion ND [plasmamembrane]Ig kappa chain V-Iregion Ni [plasmamembrane]NCK1 [plasmamembrane]Ig lambda chain V-Iregion VOR [plasmamembrane]Ig kappa chain V-Iregion HK101 [plasmamembrane]Ig heavy chain V-IIIregion POM [plasmamembrane]Ig kappa chain V-Iregion Ni [plasmamembrane]Ig lambda chain V-VIregion WLT [plasmamembrane]Ig kappa chain V-IIregion Cum [plasmamembrane]Ig kappa chain V-IIIregion CLL [plasmamembrane]PhosphatidylserineIGHM(?-452) [plasmamembrane]Ig kappa chain V-Iregion HK101 [plasmamembrane]Ig kappa chain V-IIIregion HAH [plasmamembrane]Ig kappa chain V-Iregion Scw [plasmamembrane]Ig heavy chain V-IIregion COR [plasmamembrane]Ig lambda chainV-III region LOI[plasma membrane]IGKC(1-106) [plasmamembrane]RELA [cytosol]CARMA1 oligomerKRAS(1-186) [plasmamembrane]BLNK [cytosol]Ig kappa chain V-IIregion FR [plasmamembrane]Ig lambda chain V-VIregion NIG-48[plasma membrane]IGLC6(?-106) [plasmamembrane]Ig heavy chain V-IIIregion CAM [plasmamembrane]Ig kappa chain V-Iregion Gal [plasmamembrane]Ig kappa chain V-IIIregion IARC/BL41[plasma membrane]Ig heavy chain V-IIIregion HIL [plasmamembrane]Ig lambda chain V-Iregion NEWM [plasmamembrane]Ig kappa chain V-IIregion FR [plasmamembrane]IGKVA18(21-?)[plasma membrane]Ig lambda chain V-IVregion Kern [plasmamembrane]PSMB6 [cytosol]Ig heavy chain V-IIIregion TRO [plasmamembrane]PSMB3 [cytosol]Ig lambda chain V-IIregion NEI [plasmamembrane]Activated PKC betaIg heavy chain V-IIIregion KOL [plasmamembrane]Ig lambda chainV-III region LOI[plasma membrane]Ig kappa chain V-IIIregion VG [plasmamembrane]STIM1 [endoplasmicreticulum membrane]Ig lambda chainV-VII region MOT[plasma membrane]CBL [plasmamembrane]HRAS(1-186) [plasmamembrane]Ig heavy chain V-IIIregion KOL [plasmamembrane]Ig lambda chain V-Iregion NEW [plasmamembrane]Ig heavy chain V-IIIregion TIL [plasmamembrane]ATPPSMD14 [cytosol]NFKB1(1-433)[cytosol]Ig kappa chain V-IVregion JI [plasmamembrane]Ig kappa chain V-IIIregion B6 [plasmamembrane]Ig heavy chain V-IIregion COR [plasmamembrane]LYN(2-512)Ig kappa chain V-Iregion Walker[plasma membrane]Ig lambda chain V-IIregion NIG-84[plasma membrane]Ig heavy chain V-IIIregion GA [plasmamembrane]Ig kappa chain V-Iregion BAN [plasmamembrane]Ig heavy chain V-IIIregion BRO [plasmamembrane]SOS1 [plasmamembrane]IGLC3(?-106) [plasmamembrane]Ig kappa chain V-IVregion B17 [plasmamembrane]Ig lambda chainV-III region SH[plasma membrane]Ig lambda chain V-Iregion NEW [plasmamembrane]Ig heavy chain V-IIIregion NIE [plasmamembrane]GRB2-1Ig kappa chain V-Iregion Ka [plasmamembrane]Ig heavy chain V-IIregion WAH [plasmamembrane]NCK1IgH heavy chainV-III region VH26precursor [plasmamembrane]Ig kappa chain V-Iregion Bi [plasmamembrane]Ig lambda chain V-IIregion TRO [plasmamembrane]p-S32,S36-NFKBIA[cytosol]Ig heavy chain V-Iregion EU [plasmamembrane]Ig lambda chain V-Iregion NIG-64[plasma membrane]Ig heavy chain V-IIIregion TIL [plasmamembrane]IGHD(?-384) [plasmamembrane]IgH heavy chainV-III region VH26precursor [plasmamembrane]Ig kappa chain V-IIregion MIL [plasmamembrane]Ig heavy chain V-IIIregion TIL [plasmamembrane]Ig lambda chain V-IVregion X [plasmamembrane]Ig heavy chain V-IIregion ARH-77[plasma membrane]p-Y194,Y195,Y272-SHC1-1(156-583)[plasma membrane]Ig kappa chain V-IIIregion GOL [plasmamembrane]Ig kappa chain V-IIIregion POM [plasmamembrane]PIK3CD [plasmamembrane]PSMB9 [cytosol]ATPIg heavy chain V-IIIregion BUR [plasmamembrane]GRB2-1 [plasmamembrane]Ig kappa chain V-IVregion JI [plasmamembrane]Ig heavy chain V-IIIregion DOB [plasmamembrane]TRPC1 [plasmamembrane]Ig heavy chain V-IIIregion BRO [plasmamembrane]Ig heavy chain V-IIIregion BUT [plasmamembrane]Ig heavy chain V-IIIregion GA [plasmamembrane]NF-kappaB:p-IkB:SCF-betaTrCPNFKB1(1-433)[cytosol]Ig lambda chain V-VIregion WLT [plasmamembrane]Ig heavy chain V-Iregion WOL [plasmamembrane]DAG [plasmamembrane]Ig kappa chain V-IIregion MIL [plasmamembrane]ATPIg kappa chain V-Iregion Walker[plasma membrane]Ig kappa chain V-Iregion AG [plasmamembrane]Ig heavy chain V-IIIregion BUT [plasmamembrane]IGKV1-5(23-?)[plasma membrane]Ig heavy chain V-IIIregion KOL [plasmamembrane]ADPIg kappa chain V-Iregion WEA [plasmamembrane]Ig lambda chain V-IIregion BUR [plasmamembrane]PSMD7(2-324)[cytosol]Ig kappa chain V-IIregion TEW [plasmamembrane]IGLC6(?-106) [plasmamembrane]Ig heavy chain V-IIIregion JON [plasmamembrane]Ig lambda chain Vregion 4A [plasmamembrane]Ig kappa chain V-Iregion EU [plasmamembrane]Ig heavy chain V-IIIregion GA [plasmamembrane]BCAP SignalosomeIg lambda chain V-Iregion WAH [plasmamembrane]Ig heavy chain V-IIIregion POM [plasmamembrane]Ig kappa chain V-Iregion DEE [plasmamembrane]Ig heavy chain V-IIIregion BUR [plasmamembrane]Ig kappa chain V-Iregion AG [plasmamembrane]Ig heavy chain V-IIIregion WAS [plasmamembrane]PSMB7 [cytosol]ITPR3 [endoplasmicreticulum membrane]Ig kappa chain V-IVregion STH [plasmamembrane]Ig lambda chain V-IIregion NEI [plasmamembrane]Ig kappa chain V-IIregion RPMI 6410[plasma membrane]p-S19,S23-NFKBIB[cytosol]Ig kappa chain V-IIIregion SIE [plasmamembrane]Ig lambda chain Vregion 4A [plasmamembrane]KRAS(1-186) [plasmamembrane]Ig lambda chain V-IVregion Kern [plasmamembrane]PPP3CB(2-524)[cytosol]Ig kappa chain V-Iregion Ka [plasmamembrane]Ig kappa chain V-IIIregion B6 [plasmamembrane]PIK3R1 [plasmamembrane]Ig lambda chain V-Iregion MEM [plasmamembrane]Ig kappa chain V-Iregion AG [plasmamembrane]Ig kappa chain V-Iregion Kue [plasmamembrane]Ig lambda chain V-IVregion Hil [plasmamembrane]Ig heavy chain V-IIregion HE [plasmamembrane]Ig kappa chain V-Iregion Kue [plasmamembrane]ATPIg lambda chain V-IIregion TOG [plasmamembrane]Ig kappa chain V-IIIregion NG9 [plasmamembrane]Ig heavy chain V-Iregion WOL [plasmamembrane]Ig heavy chain V-IIIregion ZAP [plasmamembrane]Ig kappa chain V-Iregion Ni [plasmamembrane]Ig heavy chain V-IIIregion KOL [plasmamembrane]Ig kappa chain V-IIregion GM607 [plasmamembrane]p-Y239,Y240,Y317-SHC1-2[plasma membrane]Ig lambda chain V-VIregion SUT [plasmamembrane]Ig kappa chain V-Iregion DEE [plasmamembrane]Ig kappa chain V-Iregion Daudi [plasmamembrane]Ig heavy chain V-IIIregion HIL [plasmamembrane]FBXW11 [cytosol]Ig heavy chain V-IIIregion TIL [plasmamembrane]Ig kappa chain V-IIregion FR [plasmamembrane]Ig lambda chain V-VIregion AR [plasmamembrane]Ig kappa chain V-Iregion BAN [plasmamembrane]Ig heavy chain V-IIIregion TEI [plasmamembrane]Ig kappa chain V-IVregion Len [plasmamembrane]Ig heavy chain V-Iregion HG3 [plasmamembrane]PIK3CD [plasmamembrane]Ig kappa chain V-Iregion Bi [plasmamembrane]SOS1 [plasmamembrane]Ig heavy chain V-IIIregion BUR [plasmamembrane]IGLC1(1-105) [plasmamembrane]Ig heavy chain V-IIIregion TIL [plasmamembrane]Ig heavy chain V-IIregion OU [plasmamembrane]IGHD(?-384) [plasmamembrane]Ig lambda chain V-IIregion NEI [plasmamembrane]Ig heavy chain V-IIIregion WEA [plasmamembrane]Ig kappa chain V-IIregion Cum [plasmamembrane]Ig kappa chain V-Iregion Bi [plasmamembrane]IGHV(1-?) [plasmamembrane]Ig heavy chain V-IIregion COR [plasmamembrane]Ig lambda chain V-IIregion WIN [plasmamembrane]Ig kappa chain V-Iregion Roy [plasmamembrane]Ig lambda chain V-IVregion Kern [plasmamembrane]Ig heavy chain V-Iregion SIE [plasmamembrane]Ig heavy chain V-IIIregion CAM [plasmamembrane]REL [cytosol]p-6Y-SYK [plasmamembrane]PSMC3 [cytosol]Ig kappa chain V-Iregion Hau [plasmamembrane]Ig heavy chain V-IIIregion TEI [plasmamembrane]Ig lambda chain V-IVregion Bau [plasmamembrane]Ig kappa chain V-Iregion Rei [plasmamembrane]Ig lambda chainV-III region LOI[plasma membrane]Ig heavy chain V-IIregion OU [plasmamembrane]FKBP1A:TacrolimusIg lambda chain V-IIregion BUR [plasmamembrane]Ig lambda chain V-Iregion HA [plasmamembrane]p-S559,S644,S652-CARD11(1-1147)[plasma membrane]CARMA1:BCL10:MALT1:TAK1:IKKIg kappa chain V-Iregion Daudi [plasmamembrane]Ig kappa chain V-Iregion AU [plasmamembrane]REL [cytosol]Ig heavy chain V-IIregion DAW [plasmamembrane]Ig lambda chain V-VIregion WLT [plasmamembrane]IGLC3(?-106) [plasmamembrane]Ig heavy chain V-Iregion EU [plasmamembrane]IGHV(1-?) [plasmamembrane]Ig kappa chain V-Iregion Daudi [plasmamembrane]Ig kappa chain V-IVregion JI [plasmamembrane]Ig lambda chain V-VIregion EB4 [plasmamembrane]CALM1 [cytosol]Ig heavy chain V-IIIregion BUT [plasmamembrane]Ig heavy chain V-IIIregion GAL [plasmamembrane]p-6Y-SYK [plasmamembrane]Ig heavy chain V-Iregion WOL [plasmamembrane]Fe3+ [cytosol]Ig kappa chain V-IIregion FR [plasmamembrane]Ig heavy chain V-Iregion WOL [plasmamembrane]Ig kappa chain V-Iregion BAN [plasmamembrane]Ig heavy chain V-IIregion DAW [plasmamembrane]Ig kappa chain V-Iregion Roy [plasmamembrane]Ig heavy chain V-Iregion SIE [plasmamembrane]Ig kappa chain V-Iregion Rei [plasmamembrane]Ig kappa chain V-IVregion JI [plasmamembrane]Ig heavy chain V-IIIregion TUR [plasmamembrane]Ig lambda chain V-IVregion Bau [plasmamembrane]Ig lambda chain V-IIregion WIN [plasmamembrane]Ig heavy chain V-Iregion ND [plasmamembrane]Ig lambda chain V-VIregion AR [plasmamembrane]Ig kappa chain V-Iregion CAR [plasmamembrane]Ig lambda chain V-IIregion MGC [plasmamembrane]Ig kappa chain V-Iregion EU [plasmamembrane]Ig heavy chain V-IIregion MCE [plasmamembrane]Ig kappa chain V-Iregion AU [plasmamembrane]p-5Y-BLNK [plasmamembrane]Ig kappa chain V-Iregion AU [plasmamembrane]Ig kappa chain V-IIregion TEW [plasmamembrane]IGKV1-5(23-?)[plasma membrane]PSMB4 [cytosol]Ig heavy chain V-IIIregion NIE [plasmamembrane]Ig lambda chain V-Iregion BL2 [plasmamembrane]Ig kappa chain V-IIIregion CLL [plasmamembrane]Ig lambda chain V-Iregion EPS [plasmamembrane]IGKV1-5(23-?)[plasma membrane]IGLC2(?-106) [plasmamembrane]Ig heavy chain V-IIregion ARH-77[plasma membrane]Ig kappa chain V-IIIregion VH [plasmamembrane]Ig kappa chain V-Iregion Hau [plasmamembrane]Ig lambda chain V-IVregion Hil [plasmamembrane]Ig heavy chain V-IIIregion BUT [plasmamembrane]Ig kappa chain V-Iregion Mev [plasmamembrane]Ig lambda chain V-IIregion BOH [plasmamembrane]Ig lambda chain V-IIregion TOG [plasmamembrane]IGKC(1-106) [plasmamembrane]PSME2 [cytosol]Ig heavy chain V-IIIregion WAS [plasmamembrane]Ig lambda chain V-Iregion NEWM [plasmamembrane]Ig heavy chain V-IIIregion TRO [plasmamembrane]Ig lambda chain V-Vregion DEL [plasmamembrane]Ig heavy chain V-IIregion OU [plasmamembrane]Ig heavy chain V-IIIregion LAY [plasmamembrane]Ig heavy chain V-Iregion ND [plasmamembrane]Ig lambda chain V-IIregion NIG-58[plasma membrane]REL [cytosol]Ig lambda chain V-IVregion Bau [plasmamembrane]Ig kappa chain V-IIIregion SIE [plasmamembrane]I(1,4,5)P3 [cytosol]IGKV4-1(21-?)[plasma membrane]IgH heavy chainV-III region VH26precursor [plasmamembrane]Ig heavy chain V-IIIregion JON [plasmamembrane]Ig kappa chain V-Iregion AG [plasmamembrane]Ig heavy chain V-IIregion COR [plasmamembrane]Ig lambda chain V-IVregion MOL [plasmamembrane]Ig kappa chain V-Iregion WEA [plasmamembrane]Ig lambda chainV-VII region MOT[plasma membrane]Ig heavy chain V-IIIregion DOB [plasmamembrane]PI(3,4,5)P3 [plasmamembrane]12091328717, 6811, 30, 112, 1187, 8, 108546411964104, 13146, 65, 96, 135128939811, 30, 64, 112, 1498957, 14638, 58, 93, 14778104


Description

Mature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, Fu et al. 1975, Kunkel et al. 1975, Van Noesel et al. 1992, Sanchez et al. 1993, reviewed in Brezski and Monroe 2008). Binding of antigen to the immunoglobulin activates phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the cytoplasmic tails of Ig-alpha and Ig-beta by Src family tyrosine kinases, including LYN, FYN, and BLK (Nel et al. 1984, Yamanashi et al. 1991, Flaswinkel and Reth 1994, Saouaf et al. 1994, Hata et al. 1994, Saouaf et al. 1995, reviewed in Gauld and Cambier 2004, reviewed in Harwood and Batista 2010).
The protein kinase SYK binds the phosphorylated immunoreceptor tyrosine-activated motifs (ITAMs) on the cytoplasmic tails of Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) (Wienands et al. 1995, Rowley et al. 1995, Tsang et al. 2008). The binding causes the activation and autophosphorylation of SYK (Law et al. 1994, Baldock et al. 2000, Irish et al. 2006, Tsang et al. 2008, reviewed in Bradshaw 2010).
Activated SYK and other kinases phosphorylate BLNK (SLP-65), BCAP, and CD19 which serve as scaffolds for the assembly of large complexes, the signalosomes, by recruiting phosphoinositol 3-kinase (PI3K), phospholipase C gamma (predominantly PLC-gamma2 in B cells, Coggeshall et al. 1992), NCK, BAM32, BTK, VAV1, and SHC. The effectors are phosphorylated by SYK and other kinases.
PLC-gamma associated with BLNK hydrolyzes phosphatidylinositol-4,5-bisphosphate to yield inositol-1,4,5-trisphosphate (IP3) and diacylglycerol (Carter et al. 1991, Kim et al. 2004). IP3 binds receptors on the endoplasmic reticulum and causes release of calcium ions from the ER into the cytosol. The depletion of calcium from the ER in turn activates STIM1 to interact with ORAI and TRPC1 channels in the plasma membrane, resulting in an influx of extracellular calcium ions (Muik et al. 2008, Luik et al. 2008, Park et al. 2009, Mori et al. 2002). PI3K associated with BCAP and CD19 phosphorylates phosphatidylinositol 4,5-bisphosphate to yield phosphatidyinositol 3,4,5-trisphosphate.
Second messengers (calcium, diacylglycerol, inositol 1,4,5-trisphosphate, and phosphatidylinositol 3,4,5-trisphosphate) trigger signaling pathways: NF-kappaB is activated via protein kinase C beta, RAS is activated via RasGRP proteins, NF-AT is activated via calcineurin, and AKT (PKB) is activated via PDK1 (reviewed in Shinohara and Kurosaki 2009, Stone 2006).Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=983705

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  99. Su YW, Zhang Y, Schweikert J, Koretzky GA, Reth M, Wienands J.; ''Interaction of SLP adaptors with the SH2 domain of Tec family kinases.''; PubMed Europe PMC Scholia
  100. Park H, Wahl MI, Afar DE, Turck CW, Rawlings DJ, Tam C, Scharenberg AM, Kinet JP, Witte ON.; ''Regulation of Btk function by a major autophosphorylation site within the SH3 domain.''; PubMed Europe PMC Scholia
  101. Chen TY, Illing M, Molday LL, Hsu YT, Yau KW, Molday RS.; ''Subunit 2 (or beta) of retinal rod cGMP-gated cation channel is a component of the 240-kDa channel-associated protein and mediates Ca(2+)-calmodulin modulation.''; PubMed Europe PMC Scholia
  102. Tanner MJ, Hanel W, Gaffen SL, Lin X.; ''CARMA1 coiled-coil domain is involved in the oligomerization and subcellular localization of CARMA1 and is required for T cell receptor-induced NF-kappaB activation.''; PubMed Europe PMC Scholia
  103. Suzuki H, Chiba T, Kobayashi M, Takeuchi M, Suzuki T, Ichiyama A, Ikenoue T, Omata M, Furuichi K, Tanaka K.; ''IkappaBalpha ubiquitination is catalyzed by an SCF-like complex containing Skp1, cullin-1, and two F-box/WD40-repeat proteins, betaTrCP1 and betaTrCP2.''; PubMed Europe PMC Scholia
  104. Meller N, Elitzur Y, Isakov N.; ''Protein kinase C-theta (PKCtheta) distribution analysis in hematopoietic cells: proliferating T cells exhibit high proportions of PKCtheta in the particulate fraction.''; PubMed Europe PMC Scholia
  105. Oellerich T, Bremes V, Neumann K, Bohnenberger H, Dittmann K, Hsiao HH, Engelke M, Schnyder T, Batista FD, Urlaub H, Wienands J.; ''The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85.''; PubMed Europe PMC Scholia
  106. Oellerich T, Grønborg M, Neumann K, Hsiao HH, Urlaub H, Wienands J.; ''SLP-65 phosphorylation dynamics reveals a functional basis for signal integration by receptor-proximal adaptor proteins.''; PubMed Europe PMC Scholia
  107. Brooks SR, Kirkham PM, Freeberg L, Carter RH.; ''Binding of cytoplasmic proteins to the CD19 intracellular domain is high affinity, competitive, and multimeric.''; PubMed Europe PMC Scholia
  108. Roifman CM, Ke S.; ''CD19 is a substrate of the antigen receptor-associated protein tyrosine kinase in human B cells.''; PubMed Europe PMC Scholia
  109. Clark MR, Friedrich RJ, Campbell KS, Cambier JC.; ''Human pre-B and B cell membrane mu-chains are noncovalently associated with a disulfide-linked complex containing a product of the B29 gene.''; PubMed Europe PMC Scholia
  110. Yamanashi Y, Kakiuchi T, Mizuguchi J, Yamamoto T, Toyoshima K.; ''Association of B cell antigen receptor with protein tyrosine kinase Lyn.''; PubMed Europe PMC Scholia
  111. Sundivakkam PC, Freichel M, Singh V, Yuan JP, Vogel SM, Flockerzi V, Malik AB, Tiruppathi C.; ''The Ca(2+) sensor stromal interaction molecule 1 (STIM1) is necessary and sufficient for the store-operated Ca(2+) entry function of transient receptor potential canonical (TRPC) 1 and 4 channels in endothelial cells.''; PubMed Europe PMC Scholia
  112. Zandi E, Chen Y, Karin M.; ''Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate.''; PubMed Europe PMC Scholia
  113. Coggeshall KM, McHugh JC, Altman A.; ''Predominant expression and activation-induced tyrosine phosphorylation of phospholipase C-gamma 2 in B lymphocytes.''; PubMed Europe PMC Scholia
  114. Teixeira C, Stang SL, Zheng Y, Beswick NS, Stone JC.; ''Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3.''; PubMed Europe PMC Scholia
  115. Dowler S, Montalvo L, Cantrell D, Morrice N, Alessi DR.; ''Phosphoinositide 3-kinase-dependent phosphorylation of the dual adaptor for phosphotyrosine and 3-phosphoinositides by the Src family of tyrosine kinase.''; PubMed Europe PMC Scholia
  116. Blasioli J, Paust S, Thomas ML.; ''Definition of the sites of interaction between the protein tyrosine phosphatase SHP-1 and CD22.''; PubMed Europe PMC Scholia
  117. Lorenzo PS, Kung JW, Bottorff DA, Garfield SH, Stone JC, Blumberg PM.; ''Phorbol esters modulate the Ras exchange factor RasGRP3.''; PubMed Europe PMC Scholia
  118. Huai Q, Kim HY, Liu Y, Zhao Y, Mondragon A, Liu JO, Ke H.; ''Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes.''; PubMed Europe PMC Scholia
  119. Yamashita S, Mochizuki N, Ohba Y, Tobiume M, Okada Y, Sawa H, Nagashima K, Matsuda M.; ''CalDAG-GEFIII activation of Ras, R-ras, and Rap1.''; PubMed Europe PMC Scholia
  120. Leprince C, Draves KE, Geahlen RL, Ledbetter JA, Clark EA.; ''CD22 associates with the human surface IgM-B-cell antigen receptor complex.''; PubMed Europe PMC Scholia
  121. Ferguson KM, Kavran JM, Sankaran VG, Fournier E, Isakoff SJ, Skolnik EY, Lemmon MA.; ''Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains.''; PubMed Europe PMC Scholia
  122. Saouaf SJ, Kut SA, Fargnoli J, Rowley RB, Bolen JB, Mahajan S.; ''Reconstitution of the B cell antigen receptor signaling components in COS cells.''; PubMed Europe PMC Scholia
  123. Sommer K, Guo B, Pomerantz JL, Bandaranayake AD, Moreno-García ME, Ovechkina YL, Rawlings DJ.; ''Phosphorylation of the CARMA1 linker controls NF-kappaB activation.''; PubMed Europe PMC Scholia
  124. Engels N, Wollscheid B, Wienands J.; ''Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alpha.''; PubMed Europe PMC Scholia
  125. Zhou H, Wertz I, O'Rourke K, Ultsch M, Seshagiri S, Eby M, Xiao W, Dixit VM.; ''Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO.''; PubMed Europe PMC Scholia
  126. Kim LJ, Ferguson HA, Seto AG, Goodrich JA.; ''Characterization of DNA binding, transcriptional activation, and regulated nuclear association of recombinant human NFATp.''; PubMed Europe PMC Scholia
  127. Tsang E, Giannetti AM, Shaw D, Dinh M, Tse JK, Gandhi S, Ho H, Wang S, Papp E, Bradshaw JM.; ''Molecular mechanism of the Syk activation switch.''; PubMed Europe PMC Scholia
  128. Rebhun JF, Castro AF, Quilliam LA.; ''Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction.''; PubMed Europe PMC Scholia
  129. Ozdener F, Dangelmaier C, Ashby B, Kunapuli SP, Daniel JL.; ''Activation of phospholipase Cgamma2 by tyrosine phosphorylation.''; PubMed Europe PMC Scholia
  130. Cheng KT, Liu X, Ong HL, Ambudkar IS.; ''Functional requirement for Orai1 in store-operated TRPC1-STIM1 channels.''; PubMed Europe PMC Scholia
  131. Traenckner EB, Wilk S, Baeuerle PA.; ''A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B.''; PubMed Europe PMC Scholia
  132. Nore BF, Mattsson PT, Antonsson P, Bäckesjö CM, Westlund A, Lennartsson J, Hansson H, Löw P, Rönnstrand L, Smith CI.; ''Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases.''; PubMed Europe PMC Scholia
  133. Roifman CM, Mills GB, Stewart D, Cheung RK, Grinstein S, Gelfand EW.; ''Response of human B cells to different anti-immunoglobulin isotypes: absence of a correlation between early activation events and cell proliferation.''; PubMed Europe PMC Scholia
  134. Kabak S, Skaggs BJ, Gold MR, Affolter M, West KL, Foster MS, Siemasko K, Chan AC, Aebersold R, Clark MR.; ''The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways.''; PubMed Europe PMC Scholia
  135. Gold MR, Chan VW, Turck CW, DeFranco AL.; ''Membrane Ig cross-linking regulates phosphatidylinositol 3-kinase in B lymphocytes.''; PubMed Europe PMC Scholia
  136. Muik M, Frischauf I, Derler I, Fahrner M, Bergsmann J, Eder P, Schindl R, Hesch C, Polzinger B, Fritsch R, Kahr H, Madl J, Gruber H, Groschner K, Romanin C.; ''Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation.''; PubMed Europe PMC Scholia
  137. Wang C, Deng L, Hong M, Akkaraju GR, Inoue J, Chen ZJ.; ''TAK1 is a ubiquitin-dependent kinase of MKK and IKK.''; PubMed Europe PMC Scholia
  138. Rolli V, Gallwitz M, Wossning T, Flemming A, Schamel WW, Zürn C, Reth M.; ''Amplification of B cell antigen receptor signaling by a Syk/ITAM positive feedback loop.''; PubMed Europe PMC Scholia
  139. Hanasaki K, Powell LD, Varki A.; ''Binding of human plasma sialoglycoproteins by the B cell-specific lectin CD22. Selective recognition of immunoglobulin M and haptoglobin.''; PubMed Europe PMC Scholia
  140. Nisitani S, Kato RM, Rawlings DJ, Witte ON, Wahl MI.; ''In situ detection of activated Bruton's tyrosine kinase in the Ig signaling complex by phosphopeptide-specific monoclonal antibodies.''; PubMed Europe PMC Scholia
  141. Kunkel HG.; ''Surface markers of human lymphocytes.''; PubMed Europe PMC Scholia
  142. Bohnenberger H, Oellerich T, Engelke M, Hsiao HH, Urlaub H, Wienands J.; ''Complex phosphorylation dynamics control the composition of the Syk interactome in B cells.''; PubMed Europe PMC Scholia
  143. Li Z, Nabel GJ.; ''A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription.''; PubMed Europe PMC Scholia
  144. Rodriguez R, Matsuda M, Perisic O, Bravo J, Paul A, Jones NP, Light Y, Swann K, Williams RL, Katan M.; ''Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling.''; PubMed Europe PMC Scholia
  145. Chiu CW, Dalton M, Ishiai M, Kurosaki T, Chan AC.; ''BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins.''; PubMed Europe PMC Scholia
  146. Alland L, Peseckis SM, Atherton RE, Berthiaume L, Resh MD.; ''Dual myristylation and palmitylation of Src family member p59fyn affects subcellular localization.''; PubMed Europe PMC Scholia
  147. Smith KG, Tarlinton DM, Doody GM, Hibbs ML, Fearon DT.; ''Inhibition of the B cell by CD22: a requirement for Lyn.''; PubMed Europe PMC Scholia
  148. Sanchez M, Misulovin Z, Burkhardt AL, Mahajan S, Costa T, Franke R, Bolen JB, Nussenzweig M.; ''Signal transduction by immunoglobulin is mediated through Ig alpha and Ig beta.''; PubMed Europe PMC Scholia
  149. Wu C, Ghosh S.; ''beta-TrCP mediates the signal-induced ubiquitination of IkappaBbeta.''; PubMed Europe PMC Scholia
  150. Okamura H, Aramburu J, García-Rodríguez C, Viola JP, Raghavan A, Tahiliani M, Zhang X, Qin J, Hogan PG, Rao A.; ''Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity.''; PubMed Europe PMC Scholia
  151. Lin L, Czerwinski R, Kelleher K, Siegel MM, Wu P, Kriz R, Aulabaugh A, Stahl M.; ''Activation loop phosphorylation modulates Bruton's tyrosine kinase (Btk) kinase domain activity.''; PubMed Europe PMC Scholia
  152. Nel AE, Landreth GE, Goldschmidt-Clermont PJ, Tung HE, Galbraith RM.; ''Enhanced tyrosine phosphorylation in B lymphocytes upon complexing of membrane immunoglobulin.''; PubMed Europe PMC Scholia
  153. Padeh S, Levitzki A, Gazit A, Mills GB, Roifman CM.; ''Activation of phospholipase C in human B cells is dependent on tyrosine phosphorylation.''; PubMed Europe PMC Scholia
  154. Roose JP, Mollenauer M, Ho M, Kurosaki T, Weiss A.; ''Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes.''; PubMed Europe PMC Scholia
  155. Han S, Collins BE, Bengtson P, Paulson JC.; ''Homomultimeric complexes of CD22 in B cells revealed by protein-glycan cross-linking.''; PubMed Europe PMC Scholia
  156. Salim K, Bottomley MJ, Querfurth E, Zvelebil MJ, Gout I, Scaife R, Margolis RL, Gigg R, Smith CI, Driscoll PC, Waterfield MD, Panayotou G.; ''Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase.''; PubMed Europe PMC Scholia
  157. Wienands J, Schweikert J, Wollscheid B, Jumaa H, Nielsen PJ, Reth M.; ''SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation.''; PubMed Europe PMC Scholia
  158. Brezski RJ, Monroe JG.; ''B-cell receptor.''; PubMed Europe PMC Scholia
  159. Luik RM, Wang B, Prakriya M, Wu MM, Lewis RS.; ''Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation.''; PubMed Europe PMC Scholia
  160. Leitges M, Schmedt C, Guinamard R, Davoust J, Schaal S, Stabel S, Tarakhovsky A.; ''Immunodeficiency in protein kinase cbeta-deficient mice.''; PubMed Europe PMC Scholia
  161. Burke JR, Wood MK, Ryseck RP, Walther S, Meyers CA.; ''Peptides corresponding to the N and C termini of IkappaB-alpha, -beta, and -epsilon as probes of the two catalytic subunits of IkappaB kinase, IKK-1 and IKK-2.''; PubMed Europe PMC Scholia
  162. Vasile S, Coligan JE, Yoshida M, Seon BK.; ''Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex.''; PubMed Europe PMC Scholia
  163. Wienands J, Hombach J, Radbruch A, Riesterer C, Reth M.; ''Molecular components of the B cell antigen receptor complex of class IgD differ partly from those of IgM.''; PubMed Europe PMC Scholia
  164. Fu C, Chan AC.; ''Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activation.''; PubMed Europe PMC Scholia
  165. Roose JP, Mollenauer M, Gupta VA, Stone J, Weiss A.; ''A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells.''; PubMed Europe PMC Scholia
  166. Blank V, Kourilsky P, Israël A.; ''Cytoplasmic retention, DNA binding and processing of the NF-kappa B p50 precursor are controlled by a small region in its C-terminus.''; PubMed Europe PMC Scholia
  167. McConnell FM, Shears SB, Lane PJ, Scheibel MS, Clark EA.; ''Relationships between the degree of cross-linking of surface immunoglobulin and the associated inositol 1,4,5-trisphosphate and Ca2+ signals in human B cells.''; PubMed Europe PMC Scholia
  168. Wei SJ, Williams JG, Dang H, Darden TA, Betz BL, Humble MM, Chang FM, Trempus CS, Johnson K, Cannon RE, Tennant RW.; ''Identification of a specific motif of the DSS1 protein required for proteasome interaction and p53 protein degradation.''; PubMed Europe PMC Scholia
  169. Brooks SR, Li X, Volanakis EJ, Carter RH.; ''Systematic analysis of the role of CD19 cytoplasmic tyrosines in enhancement of activation in Daudi human B cells: clustering of phospholipase C and Vav and of Grb2 and Sos with different CD19 tyrosines.''; PubMed Europe PMC Scholia
  170. Su TT, Guo B, Kawakami Y, Sommer K, Chae K, Humphries LA, Kato RM, Kang S, Patrone L, Wall R, Teitell M, Leitges M, Kawakami T, Rawlings DJ.; ''PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling.''; PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
112687view16:08, 9 October 2020ReactomeTeamReactome version 73
101604view11:47, 1 November 2018ReactomeTeamreactome version 66
101140view21:32, 31 October 2018ReactomeTeamreactome version 65
100668view20:06, 31 October 2018ReactomeTeamreactome version 64
100218view16:51, 31 October 2018ReactomeTeamreactome version 63
99769view15:17, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
93934view13:46, 16 August 2017ReactomeTeamreactome version 61
93521view11:25, 9 August 2017ReactomeTeamreactome version 61
87188view08:07, 19 July 2016EgonwOntology Term : 'signaling pathway' added !
86619view09:22, 11 July 2016ReactomeTeamreactome version 56
83158view10:13, 18 November 2015ReactomeTeamVersion54
81511view13:03, 21 August 2015ReactomeTeamVersion53
76984view08:27, 17 July 2014ReactomeTeamFixed remaining interactions
76689view12:05, 16 July 2014ReactomeTeamFixed remaining interactions
76015view10:07, 11 June 2014ReactomeTeamRe-fixing comment source
75724view11:19, 10 June 2014ReactomeTeamReactome 48 Update
75074view14:02, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74860view17:46, 2 May 2014EgonwMarked two metabolites as a DataNode type="Metabolite"...
74721view08:48, 30 April 2014ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
26S proteasomeComplexREACT_2353 (Reactome)
ADPMetaboliteCHEBI:16761 (ChEBI)
ATPMetaboliteCHEBI:15422 (ChEBI)
Activated PKC betaComplexREACT_4856 (Reactome)
Active CalmodulinComplexREACT_3178 (Reactome)
Active IKK complexComplexREACT_119869 (Reactome)
Antigen:BCRComplexREACT_119368 (Reactome)
Antigen:p-BCR:SYKComplexREACT_120132 (Reactome)
Antigen:p-BCR:p-SYK:p-BLNKComplexREACT_120231 (Reactome)
Antigen:p-BCR:p-SYKComplexREACT_120006 (Reactome)
Antigen:p-BCRComplexREACT_119697 (Reactome)
AntigenREACT_119525 (Reactome)
BCAP SignalosomeComplexREACT_119322 (Reactome)
BCRComplexREACT_119956 (Reactome)
BLK(2-505)ProteinP51451 (Uniprot-TrEMBL)
BLNK (SLP-65) SignalosomeComplexREACT_120226 (Reactome)
BLNK [cytosol]ProteinQ8WV28 (Uniprot-TrEMBL)
BLNK:GRB2:SOS1:CIN85:CBLComplexREACT_120158 (Reactome)
BTKProteinQ06187 (Uniprot-TrEMBL)
BTRC [cytosol]ProteinQ9Y297 (Uniprot-TrEMBL)
CALM1 [cytosol]ProteinP62158 (Uniprot-TrEMBL)
CALM1ProteinP62158 (Uniprot-TrEMBL)
CARD11(1-1147) [cytosol]ProteinQ9BXL7 (Uniprot-TrEMBL)
CARMA1 oligomerComplexREACT_119167 (Reactome)
CARMA1:BCL10:MALT1:TAK1:IKKComplexREACT_118993 (Reactome) TAK1 and the IKK complex are observed to migrate to lipid rafts containing phosphorylated CARMA1, BCL10, and MALT1. By analogy with NF-kappaB signaling pathways in other cells, the CARMA1:BCL10MALT1:TAK1:IKK complex in B cells may also contain TAB1, TAB2 and/or TAB3, TRAF6.
CARMA1:BCL10:MALT1:TAK1ComplexREACT_119896 (Reactome) TAK1 and the IKK complex are observed to migrate to lipid rafts containing phosphorylated CARMA1, BCL10, and MALT1. By analogy with NF-kappaB signaling pathways in other cells, the CARMA1:BCL10MALT1:TAK1:IKK complex in B cells may also contain TAB1, TAB2 and/or TAB3, TRAF6.
CARMA1:MALT1:BCL10ComplexREACT_119308 (Reactome)
CBL [cytosol]ProteinP22681 (Uniprot-TrEMBL)
CBL [plasma membrane]ProteinP22681 (Uniprot-TrEMBL)
CBLB [cytosol]ProteinQ13191 (Uniprot-TrEMBL)
CBLB [plasma membrane]ProteinQ13191 (Uniprot-TrEMBL)
CD19 SignalosomeComplexREACT_119603 (Reactome)
CD19 [plasma membrane]ProteinP15391 (Uniprot-TrEMBL)
CD19:VAV1ComplexREACT_119973 (Reactome)
CD79A [plasma membrane]ProteinP11912 (Uniprot-TrEMBL)
CD79B [plasma membrane]ProteinP40259 (Uniprot-TrEMBL)
CHUK [cytosol]ProteinO15111 (Uniprot-TrEMBL)
CHUK [plasma membrane]ProteinO15111 (Uniprot-TrEMBL)
CRAC channelComplexREACT_24443 (Reactome)
CUL1 [cytosol]ProteinQ13616 (Uniprot-TrEMBL)
Ca2+ [cytosol]MetaboliteCHEBI:29108 (ChEBI)
Ca2+ [endoplasmic reticulum lumen]MetaboliteCHEBI:29108 (ChEBI)
Ca2+ [plasma membrane]MetaboliteCHEBI:29108 (ChEBI)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
Calcineurin (CaN)ComplexREACT_119672 (Reactome)
Calcineurin:Phosphorylated NFATC1/2/3ComplexREACT_119836 (Reactome)
Cyclophilin A:Cyclosporin AComplexREACT_119713 (Reactome)
Cyclosporin A [cytosol]MetaboliteCHEBI:4031 (ChEBI)
DAG [plasma membrane]MetaboliteCHEBI:17815 (ChEBI)
DAGCHEBI:17815 (ChEBI)
DAPP1ProteinQ9UN19 (Uniprot-TrEMBL)
Dephosphorylated NFATC1/2/3ProteinREACT_119501 (Reactome)
FBXW11 [cytosol]ProteinQ9UKB1 (Uniprot-TrEMBL)
FKBP1A [cytosol]ProteinP62942 (Uniprot-TrEMBL)
FKBP1A:TacrolimusComplexREACT_120070 (Reactome)
FYN(2-537)ProteinP06241 (Uniprot-TrEMBL)
Fe3+ [cytosol]MetaboliteCHEBI:29034 (ChEBI)
GDP [cytosol]MetaboliteCHEBI:17552 (ChEBI)
GRB2-1 [cytosol]ProteinP62993-1 (Uniprot-TrEMBL)
GRB2-1 [plasma membrane]ProteinP62993-1 (Uniprot-TrEMBL)
GRB2-1ProteinP62993-1 (Uniprot-TrEMBL)
GTP [cytosol]MetaboliteCHEBI:15996 (ChEBI)
HRAS(1-186) [plasma membrane]ProteinP01112 (Uniprot-TrEMBL)
I(1,4,5)P3 [cytosol]MetaboliteCHEBI:16595 (ChEBI)
I(1,4,5)P3MetaboliteCHEBI:16595 (ChEBI)
IGHD(?-384) [plasma membrane]ProteinP01880 (Uniprot-TrEMBL)
IGHM(?-452) [plasma membrane]ProteinP01871 (Uniprot-TrEMBL)
IGHV(1-?) [plasma membrane]ProteinA2KUC3 (Uniprot-TrEMBL)
IGHV7-81(1-?) [plasma membrane]ProteinQ6PIL0 (Uniprot-TrEMBL)
IGKC(1-106) [plasma membrane]ProteinP01834 (Uniprot-TrEMBL)
IGKV1-5(23-?) [plasma membrane]ProteinP01602 (Uniprot-TrEMBL)
IGKV4-1(21-?) [plasma membrane]ProteinP06312 (Uniprot-TrEMBL)
IGKVA18(21-?) [plasma membrane]ProteinA2NJV5 (Uniprot-TrEMBL)
IGLC1(1-105) [plasma membrane]ProteinP0CG04 (Uniprot-TrEMBL)
IGLC2(?-106) [plasma membrane]ProteinP0CG05 (Uniprot-TrEMBL)
IGLC3(?-106) [plasma membrane]ProteinP0CG06 (Uniprot-TrEMBL)
IGLC6(?-106) [plasma membrane]ProteinP0CF74 (Uniprot-TrEMBL)
IGLC7(?-106) [plasma membrane]ProteinA0M8Q6 (Uniprot-TrEMBL)
IGLV(23-?) [plasma membrane]ProteinA2NXD2 (Uniprot-TrEMBL)
IKBKB [cytosol]ProteinO14920 (Uniprot-TrEMBL)
IKBKB [plasma membrane]ProteinO14920 (Uniprot-TrEMBL)
IKBKG [cytosol]ProteinQ9Y6K9 (Uniprot-TrEMBL)
IKBKG [plasma membrane]ProteinQ9Y6K9 (Uniprot-TrEMBL)
IKKA:IKKB:NEMOComplexREACT_7693 (Reactome)
IP3 receptor homotetramerComplexREACT_12247 (Reactome)
IP3 receptor:IP3 complexComplexREACT_12249 (Reactome)
ITPR1 [endoplasmic reticulum membrane]ProteinQ14643 (Uniprot-TrEMBL)
ITPR2 [endoplasmic reticulum membrane]ProteinQ14571 (Uniprot-TrEMBL)
ITPR3 [endoplasmic reticulum membrane]ProteinQ14573 (Uniprot-TrEMBL)
Ig heavy chain V-I

region EU [plasma

membrane]		ProteinP01742 (Uniprot-TrEMBL)
Ig heavy chain V-I

region HG3 [plasma

membrane]		ProteinP01743 (Uniprot-TrEMBL)
Ig heavy chain V-I

region Mot [plasma

membrane]		ProteinP06326 (Uniprot-TrEMBL)
Ig heavy chain V-I

region ND [plasma

membrane]		ProteinP01744 (Uniprot-TrEMBL)
Ig heavy chain V-I

region SIE [plasma

membrane]		ProteinP01761 (Uniprot-TrEMBL)
Ig heavy chain V-I

region WOL [plasma

membrane]		ProteinP01760 (Uniprot-TrEMBL)
Ig heavy chain V-II

region ARH-77

[plasma membrane]		ProteinP06331 (Uniprot-TrEMBL)
Ig heavy chain V-II

region COR [plasma

membrane]		ProteinP01815 (Uniprot-TrEMBL)
Ig heavy chain V-II

region DAW [plasma

membrane]		ProteinP01816 (Uniprot-TrEMBL)
Ig heavy chain V-II

region HE [plasma

membrane]		ProteinP01818 (Uniprot-TrEMBL)
Ig heavy chain V-II

region MCE [plasma

membrane]		ProteinP01817 (Uniprot-TrEMBL)
Ig heavy chain V-II

region NEWM [plasma

membrane]		ProteinP01825 (Uniprot-TrEMBL)
Ig heavy chain V-II

region OU [plasma

membrane]		ProteinP01814 (Uniprot-TrEMBL)
Ig heavy chain V-II

region SESS [plasma

membrane]		ProteinP04438 (Uniprot-TrEMBL)
Ig heavy chain V-II

region WAH [plasma

membrane]		ProteinP01824 (Uniprot-TrEMBL)
Ig heavy chain V-III

region BRO [plasma

membrane]		ProteinP01766 (Uniprot-TrEMBL)
Ig heavy chain V-III

region BUR [plasma

membrane]		ProteinP01773 (Uniprot-TrEMBL)
Ig heavy chain V-III

region BUT [plasma

membrane]		ProteinP01767 (Uniprot-TrEMBL)
Ig heavy chain V-III

region CAM [plasma

membrane]		ProteinP01768 (Uniprot-TrEMBL)
Ig heavy chain V-III

region DOB [plasma

membrane]		ProteinP01782 (Uniprot-TrEMBL)
Ig heavy chain V-III

region GA [plasma

membrane]		ProteinP01769 (Uniprot-TrEMBL)
Ig heavy chain V-III

region GAL [plasma

membrane]		ProteinP01781 (Uniprot-TrEMBL)
Ig heavy chain V-III

region HIL [plasma

membrane]		ProteinP01771 (Uniprot-TrEMBL)
Ig heavy chain V-III

region JON [plasma

membrane]		ProteinP01780 (Uniprot-TrEMBL)
Ig heavy chain V-III

region KOL [plasma

membrane]		ProteinP01772 (Uniprot-TrEMBL)
Ig heavy chain V-III

region LAY [plasma

membrane]		ProteinP01775 (Uniprot-TrEMBL)
Ig heavy chain V-III

region NIE [plasma

membrane]		ProteinP01770 (Uniprot-TrEMBL)
Ig heavy chain V-III

region POM [plasma

membrane]		ProteinP01774 (Uniprot-TrEMBL)
Ig heavy chain V-III

region TEI [plasma

membrane]		ProteinP01777 (Uniprot-TrEMBL)
Ig heavy chain V-III

region TIL [plasma

membrane]		ProteinP01765 (Uniprot-TrEMBL)
Ig heavy chain V-III

region TRO [plasma

membrane]		ProteinP01762 (Uniprot-TrEMBL)
Ig heavy chain V-III

region TUR [plasma

membrane]		ProteinP01779 (Uniprot-TrEMBL)
Ig heavy chain V-III

region WAS [plasma

membrane]		ProteinP01776 (Uniprot-TrEMBL)
Ig heavy chain V-III

region WEA [plasma

membrane]		ProteinP01763 (Uniprot-TrEMBL)
Ig heavy chain V-III

region ZAP [plasma

membrane]		ProteinP01778 (Uniprot-TrEMBL)
Ig kappa chain V

region EV15 [plasma

membrane]		ProteinP06315 (Uniprot-TrEMBL)
Ig kappa chain V-I

region AG [plasma

membrane]		ProteinP01593 (Uniprot-TrEMBL)
Ig kappa chain V-I

region AU [plasma

membrane]		ProteinP01594 (Uniprot-TrEMBL)
Ig kappa chain V-I

region BAN [plasma

membrane]		ProteinP04430 (Uniprot-TrEMBL)
Ig kappa chain V-I

region Bi [plasma

membrane]		ProteinP01595 (Uniprot-TrEMBL)
Ig kappa chain V-I

region CAR [plasma

membrane]		ProteinP01596 (Uniprot-TrEMBL)
Ig kappa chain V-I

region DEE [plasma

membrane]		ProteinP01597 (Uniprot-TrEMBL)
Ig kappa chain V-I

region Daudi [plasma

membrane]		ProteinP04432 (Uniprot-TrEMBL)
Ig kappa chain V-I

region EU [plasma

membrane]		ProteinP01598 (Uniprot-TrEMBL)
Ig kappa chain V-I

region Gal [plasma

membrane]		ProteinP01599 (Uniprot-TrEMBL)
Ig kappa chain V-I

region HK101 [plasma

membrane]		ProteinP01601 (Uniprot-TrEMBL)
Ig kappa chain V-I

region Hau [plasma

membrane]		ProteinP01600 (Uniprot-TrEMBL)
Ig kappa chain V-I

region Ka [plasma

membrane]		ProteinP01603 (Uniprot-TrEMBL)
Ig kappa chain V-I

region Kue [plasma

membrane]		ProteinP01604 (Uniprot-TrEMBL)
Ig kappa chain V-I

region Lay [plasma

membrane]		ProteinP01605 (Uniprot-TrEMBL)
Ig kappa chain V-I

region Mev [plasma

membrane]		ProteinP01612 (Uniprot-TrEMBL)
Ig kappa chain V-I

region Ni [plasma

membrane]		ProteinP01613 (Uniprot-TrEMBL)
Ig kappa chain V-I

region OU [plasma

membrane]		ProteinP01606 (Uniprot-TrEMBL)
Ig kappa chain V-I

region Rei [plasma

membrane]		ProteinP01607 (Uniprot-TrEMBL)
Ig kappa chain V-I

region Roy [plasma

membrane]		ProteinP01608 (Uniprot-TrEMBL)
Ig kappa chain V-I

region Scw [plasma

membrane]		ProteinP01609 (Uniprot-TrEMBL)
Ig kappa chain V-I

region WAT [plasma

membrane]		ProteinP80362 (Uniprot-TrEMBL)
Ig kappa chain V-I

region WEA [plasma

membrane]		ProteinP01610 (Uniprot-TrEMBL)
Ig kappa chain V-I

region Walker

[plasma membrane]		ProteinP04431 (Uniprot-TrEMBL)
Ig kappa chain V-I

region Wes [plasma

membrane]		ProteinP01611 (Uniprot-TrEMBL)
Ig kappa chain V-II

region Cum [plasma

membrane]		ProteinP01614 (Uniprot-TrEMBL)
Ig kappa chain V-II

region FR [plasma

membrane]		ProteinP01615 (Uniprot-TrEMBL)
Ig kappa chain V-II

region GM607 [plasma

membrane]		ProteinP06309 (Uniprot-TrEMBL)
Ig kappa chain V-II

region MIL [plasma

membrane]		ProteinP01616 (Uniprot-TrEMBL)
Ig kappa chain V-II

region RPMI 6410

[plasma membrane]		ProteinP06310 (Uniprot-TrEMBL)
Ig kappa chain V-II

region TEW [plasma

membrane]		ProteinP01617 (Uniprot-TrEMBL)
Ig kappa chain V-III

region B6 [plasma

membrane]		ProteinP01619 (Uniprot-TrEMBL)
Ig kappa chain V-III

region CLL [plasma

membrane]		ProteinP04207 (Uniprot-TrEMBL)
Ig kappa chain V-III

region GOL [plasma

membrane]		ProteinP04206 (Uniprot-TrEMBL)
Ig kappa chain V-III

region HAH [plasma

membrane]		ProteinP18135 (Uniprot-TrEMBL)
Ig kappa chain V-III

region HIC [plasma

membrane]		ProteinP18136 (Uniprot-TrEMBL)
Ig kappa chain V-III

region IARC/BL41

[plasma membrane]		ProteinP06311 (Uniprot-TrEMBL)
Ig kappa chain V-III

region NG9 [plasma

membrane]		ProteinP01621 (Uniprot-TrEMBL)
Ig kappa chain V-III

region POM [plasma

membrane]		ProteinP01624 (Uniprot-TrEMBL)
Ig kappa chain V-III

region SIE [plasma

membrane]		ProteinP01620 (Uniprot-TrEMBL)
Ig kappa chain V-III

region Ti [plasma

membrane]		ProteinP01622 (Uniprot-TrEMBL)
Ig kappa chain V-III

region VG [plasma

membrane]		ProteinP04433 (Uniprot-TrEMBL)
Ig kappa chain V-III

region VH [plasma

membrane]		ProteinP04434 (Uniprot-TrEMBL)
Ig kappa chain V-III

region WOL [plasma

membrane]		ProteinP01623 (Uniprot-TrEMBL)
Ig kappa chain V-IV

region B17 [plasma

membrane]		ProteinP06314 (Uniprot-TrEMBL)
Ig kappa chain V-IV

region JI [plasma

membrane]		ProteinP06313 (Uniprot-TrEMBL)
Ig kappa chain V-IV

region Len [plasma

membrane]		ProteinP01625 (Uniprot-TrEMBL)
Ig kappa chain V-IV

region STH [plasma

membrane]		ProteinP83593 (Uniprot-TrEMBL)
Ig lambda chain

V-III region LOI

[plasma membrane]		ProteinP80748 (Uniprot-TrEMBL)
Ig lambda chain

V-III region SH

[plasma membrane]		ProteinP01714 (Uniprot-TrEMBL)
Ig lambda chain

V-VII region MOT

[plasma membrane]		ProteinP01720 (Uniprot-TrEMBL)
Ig lambda chain V

region 4A [plasma

membrane]		ProteinP04211 (Uniprot-TrEMBL)
Ig lambda chain V-I

region BL2 [plasma

membrane]		ProteinP06316 (Uniprot-TrEMBL)
Ig lambda chain V-I

region EPS [plasma

membrane]		ProteinP06888 (Uniprot-TrEMBL)
Ig lambda chain V-I

region HA [plasma

membrane]		ProteinP01700 (Uniprot-TrEMBL)
Ig lambda chain V-I

region MEM [plasma

membrane]		ProteinP06887 (Uniprot-TrEMBL)
Ig lambda chain V-I

region NEW [plasma

membrane]		ProteinP01701 (Uniprot-TrEMBL)
Ig lambda chain V-I

region NEWM [plasma

membrane]		ProteinP01703 (Uniprot-TrEMBL)
Ig lambda chain V-I

region NIG-64

[plasma membrane]		ProteinP01702 (Uniprot-TrEMBL)
Ig lambda chain V-I

region VOR [plasma

membrane]		ProteinP01699 (Uniprot-TrEMBL)
Ig lambda chain V-I

region WAH [plasma

membrane]		ProteinP04208 (Uniprot-TrEMBL)
Ig lambda chain V-II

region BO [plasma

membrane]		ProteinP01710 (Uniprot-TrEMBL)
Ig lambda chain V-II

region BOH [plasma

membrane]		ProteinP01706 (Uniprot-TrEMBL)
Ig lambda chain V-II

region BUR [plasma

membrane]		ProteinP01708 (Uniprot-TrEMBL)
Ig lambda chain V-II

region MGC [plasma

membrane]		ProteinP01709 (Uniprot-TrEMBL)
Ig lambda chain V-II

region NEI [plasma

membrane]		ProteinP01705 (Uniprot-TrEMBL)
Ig lambda chain V-II

region NIG-58

[plasma membrane]		ProteinP01713 (Uniprot-TrEMBL)
Ig lambda chain V-II

region NIG-84

[plasma membrane]		ProteinP04209 (Uniprot-TrEMBL)
Ig lambda chain V-II

region TOG [plasma

membrane]		ProteinP01704 (Uniprot-TrEMBL)
Ig lambda chain V-II

region TRO [plasma

membrane]		ProteinP01707 (Uniprot-TrEMBL)
Ig lambda chain V-II

region VIL [plasma

membrane]		ProteinP01711 (Uniprot-TrEMBL)
Ig lambda chain V-II

region WIN [plasma

membrane]		ProteinP01712 (Uniprot-TrEMBL)
Ig lambda chain V-IV

region Bau [plasma

membrane]		ProteinP01715 (Uniprot-TrEMBL)
Ig lambda chain V-IV

region Hil [plasma

membrane]		ProteinP01717 (Uniprot-TrEMBL)
Ig lambda chain V-IV

region Kern [plasma

membrane]		ProteinP01718 (Uniprot-TrEMBL)
Ig lambda chain V-IV

region MOL [plasma

membrane]		ProteinP06889 (Uniprot-TrEMBL)
Ig lambda chain V-IV

region X [plasma

membrane]		ProteinP01716 (Uniprot-TrEMBL)
Ig lambda chain V-V

region DEL [plasma

membrane]		ProteinP01719 (Uniprot-TrEMBL)
Ig lambda chain V-VI

region AR [plasma

membrane]		ProteinP01721 (Uniprot-TrEMBL)
Ig lambda chain V-VI

region EB4 [plasma

membrane]		ProteinP06319 (Uniprot-TrEMBL)
Ig lambda chain V-VI

region NIG-48

[plasma membrane]		ProteinP01722 (Uniprot-TrEMBL)
Ig lambda chain V-VI

region SUT [plasma

membrane]		ProteinP06317 (Uniprot-TrEMBL)
Ig lambda chain V-VI

region WLT [plasma

membrane]		ProteinP06318 (Uniprot-TrEMBL)
IgH heavy chain

V-III region VH26 precursor [plasma

membrane]		ProteinP01764 (Uniprot-TrEMBL)
KRAS(1-186) [plasma membrane]ProteinP01116 (Uniprot-TrEMBL)
LYN(2-512)ProteinP07948 (Uniprot-TrEMBL)
MALT1 [plasma membrane]ProteinQ9UDY8 (Uniprot-TrEMBL)
MALT1ProteinQ9UDY8 (Uniprot-TrEMBL)
MAP3K7ProteinO43318 (Uniprot-TrEMBL)
NCK1 [plasma membrane]ProteinP16333 (Uniprot-TrEMBL)
NCK1ProteinP16333 (Uniprot-TrEMBL)
NF-kappa-B p50,/p65,/c-Rel:IKBComplexREACT_119154 (Reactome)
NF-kappa-B p50/ p65/c-Rel:p-IKBComplexREACT_119527 (Reactome)
NF-kappaB p50/p65/c-Rel DimerComplexREACT_118873 (Reactome)
NF-kappaB p50/p65/c-Rel DimerComplexREACT_119326 (Reactome)
NF-kappaB p50/p65/c-Rel:ub-p-IKBComplexREACT_120175 (Reactome)
NF-kappaB:p-IkB:SCF-betaTrCPComplexREACT_119791 (Reactome)
NFKB1(1-433) [cytosol]ProteinP19838 (Uniprot-TrEMBL)
NFKB1(1-433) [nucleoplasm]ProteinP19838 (Uniprot-TrEMBL)
NFKBIA [cytosol]ProteinP25963 (Uniprot-TrEMBL)
NFKBIB [cytosol]ProteinQ15653 (Uniprot-TrEMBL)
NFKBIE [cytosol]ProteinO00221 (Uniprot-TrEMBL)
NRAS [plasma membrane]ProteinP01111 (Uniprot-TrEMBL)
ORAI1 [plasma membrane]ProteinQ96D31 (Uniprot-TrEMBL)
Orai1 dimerComplexREACT_24301 (Reactome)
PI(3,4,5)P3 [plasma membrane]MetaboliteCHEBI:16618 (ChEBI)
PI(3,4,5)P3MetaboliteCHEBI:16618 (ChEBI)
PI(4,5)P2MetaboliteCHEBI:18348 (ChEBI)
PIK3AP1ProteinQ6ZUJ8 (Uniprot-TrEMBL)
PIK3CD [cytosol]ProteinO00329 (Uniprot-TrEMBL)
PIK3CD [plasma membrane]ProteinO00329 (Uniprot-TrEMBL)
PIK3CD:PIK3R1ComplexREACT_119117 (Reactome)
PIK3CD:PIK3R1ComplexREACT_119537 (Reactome)
PIK3R1 [cytosol]ProteinP27986 (Uniprot-TrEMBL)
PIK3R1 [plasma membrane]ProteinP27986 (Uniprot-TrEMBL)
PIP3 activates AKT signalingPathwayWP2653 (WikiPathways) Signaling by AKT is one of the key outcomes of receptor tyrosine kinase (RTK) activation. AKT is activated by the cellular second messenger PIP3, a phospholipid that is generated by PI3K. In ustimulated cells, PI3K class IA enzymes reside in the cytosol as inactive heterodimers composed of p85 regulatory subunit and p110 catalytic subunit. In this complex, p85 stabilizes p110 while inhibiting its catalytic activity. Upon binding of extracellular ligands to RTKs, receptors dimerize and undergo autophosphorylation. The regulatory subunit of PI3K, p85, is recruited to phosphorylated cytosolic RTK domains either directly or indirectly, through adaptor proteins, leading to a conformational change in the PI3K IA heterodimer that relieves inhibition of the p110 catalytic subunit. Activated PI3K IA phosphorylates PIP2, converting it to PIP3; this reaction is negatively regulated by PTEN phosphatase. PIP3 recruits AKT to the plasma membrane, allowing TORC2 to phosphorylate a conserved serine residue of AKT. Phosphorylation of this serine induces a conformation change in AKT, exposing a conserved threonine residue that is then phosphorylated by PDPK1 (PDK1). Phosphorylation of both the threonine and the serine residue is required to fully activate AKT. The active AKT then dissociates from PIP3 and phosphorylates a number of cytosolic and nuclear proteins that play important roles in cell survival and metabolism. For a recent review of AKT signaling, please refer to Manning and Cantley, 2007.
PLC gamma1/2ProteinREACT_120292 (Reactome)
PPIA [cytosol]ProteinP62937 (Uniprot-TrEMBL)
PPP3CA [cytosol]ProteinQ08209 (Uniprot-TrEMBL)
PPP3CB(2-524) [cytosol]ProteinP16298 (Uniprot-TrEMBL)
PPP3R1 [cytosol]ProteinP63098 (Uniprot-TrEMBL)
PRKCB [plasma membrane]ProteinP05771 (Uniprot-TrEMBL)
PRKCBProteinP05771 (Uniprot-TrEMBL)
PSMA1 [cytosol]ProteinP25786 (Uniprot-TrEMBL)
PSMA2 [cytosol]ProteinP25787 (Uniprot-TrEMBL)
PSMA3 [cytosol]ProteinP25788 (Uniprot-TrEMBL)
PSMA4 [cytosol]ProteinP25789 (Uniprot-TrEMBL)
PSMA5 [cytosol]ProteinP28066 (Uniprot-TrEMBL)
PSMA6 [cytosol]ProteinP60900 (Uniprot-TrEMBL)
PSMA7(2-248) [cytosol]ProteinO14818 (Uniprot-TrEMBL)
PSMA8 [cytosol]ProteinQ8TAA3 (Uniprot-TrEMBL)
PSMB1 [cytosol]ProteinP20618 (Uniprot-TrEMBL)
PSMB10 [cytosol]ProteinP40306 (Uniprot-TrEMBL)
PSMB11 [cytosol]ProteinA5LHX3 (Uniprot-TrEMBL)
PSMB2 [cytosol]ProteinP49721 (Uniprot-TrEMBL)
PSMB3 [cytosol]ProteinP49720 (Uniprot-TrEMBL)
PSMB4 [cytosol]ProteinP28070 (Uniprot-TrEMBL)
PSMB5 [cytosol]ProteinP28074 (Uniprot-TrEMBL)
PSMB6 [cytosol]ProteinP28072 (Uniprot-TrEMBL)
PSMB7 [cytosol]ProteinQ99436 (Uniprot-TrEMBL)
PSMB8 [cytosol]ProteinP28062 (Uniprot-TrEMBL)
PSMB9 [cytosol]ProteinP28065 (Uniprot-TrEMBL)
PSMC1(2-440) [cytosol]ProteinP62191 (Uniprot-TrEMBL)
PSMC2 [cytosol]ProteinP35998 (Uniprot-TrEMBL)
PSMC3 [cytosol]ProteinP17980 (Uniprot-TrEMBL)
PSMC4 [cytosol]ProteinP43686 (Uniprot-TrEMBL)
PSMC5 [cytosol]ProteinP62195 (Uniprot-TrEMBL)
PSMC6(2-389) [cytosol]ProteinP62333 (Uniprot-TrEMBL)
PSMD1 [cytosol]ProteinQ99460 (Uniprot-TrEMBL)
PSMD10 [cytosol]ProteinO75832 (Uniprot-TrEMBL)
PSMD11 [cytosol]ProteinO00231 (Uniprot-TrEMBL)
PSMD12 [cytosol]ProteinO00232 (Uniprot-TrEMBL)
PSMD13 [cytosol]ProteinQ9UNM6 (Uniprot-TrEMBL)
PSMD14 [cytosol]ProteinO00487 (Uniprot-TrEMBL)
PSMD2 [cytosol]ProteinQ13200 (Uniprot-TrEMBL)
PSMD3 [cytosol]ProteinO43242 (Uniprot-TrEMBL)
PSMD4(2-377) [cytosol]ProteinP55036 (Uniprot-TrEMBL)
PSMD5 [cytosol]ProteinQ16401 (Uniprot-TrEMBL)
PSMD6(2-389) [cytosol]ProteinQ15008 (Uniprot-TrEMBL)
PSMD7(2-324) [cytosol]ProteinP51665 (Uniprot-TrEMBL)
PSMD8 [cytosol]ProteinP48556 (Uniprot-TrEMBL)
PSMD9 [cytosol]ProteinO00233 (Uniprot-TrEMBL)
PSME1 [cytosol]ProteinQ06323 (Uniprot-TrEMBL)
PSME2 [cytosol]ProteinQ9UL46 (Uniprot-TrEMBL)
PSME3 [cytosol]ProteinP61289 (Uniprot-TrEMBL)
PSME4 [cytosol]ProteinQ14997 (Uniprot-TrEMBL)
PSMF1(2-271) [cytosol]ProteinQ92530 (Uniprot-TrEMBL)
Phosphatidylserine [plasma membrane]MetaboliteCHEBI:18303 (ChEBI)
PhosphatidylserineCHEBI:18303 (ChEBI)
Phosphorylated NFATC1/2/3ProteinREACT_120227 (Reactome)
REL [cytosol]ProteinQ04864 (Uniprot-TrEMBL)
REL [nucleoplasm]ProteinQ04864 (Uniprot-TrEMBL)
RELA [cytosol]ProteinQ04206 (Uniprot-TrEMBL)
RELA [nucleoplasm]ProteinQ04206 (Uniprot-TrEMBL)
RasGRP1/3ProteinREACT_119242 (Reactome)
SCF-beta-TrCp1/2ComplexREACT_119753 (Reactome)
SH3KBP1 [cytosol]ProteinQ96B97 (Uniprot-TrEMBL)
SH3KBP1 [plasma membrane]ProteinQ96B97 (Uniprot-TrEMBL)
SHC1 p46/p52ProteinREACT_111758 (Reactome) SHC1 isoforms p46 and p52 are found in B cells (Smit et al. 1994).
SKP1 [cytosol]ProteinP63208 (Uniprot-TrEMBL)
SOS1 [cytosol]ProteinQ07889 (Uniprot-TrEMBL)
SOS1 [plasma membrane]ProteinQ07889 (Uniprot-TrEMBL)
STIM1 DimerComplexREACT_27372 (Reactome)
STIM1 [endoplasmic reticulum membrane]ProteinQ13586 (Uniprot-TrEMBL)
STIM1:CalciumComplexREACT_119430 (Reactome)
STIM1:TRPC1ComplexREACT_119530 (Reactome)
SYK [plasma membrane]ProteinP43405 (Uniprot-TrEMBL)
SYKProteinP43405 (Uniprot-TrEMBL)
TRPC1 [plasma membrane]ProteinP48995 (Uniprot-TrEMBL)
TRPC1ProteinP48995 (Uniprot-TrEMBL)
Tacrolimus [cytosol]MetaboliteCHEBI:61049 (ChEBI)
Ub-21,22-p-S32,S36-NFKBIA [cytosol]ProteinP25963 (Uniprot-TrEMBL)
UbProteinREACT_3316 (Reactome)
VAV1 [plasma membrane]ProteinP15498 (Uniprot-TrEMBL)
VAV1ProteinP15498 (Uniprot-TrEMBL)
Zn2+ [cytosol]MetaboliteCHEBI:29105 (ChEBI)
p-12S-NFATC1 [cytosol]ProteinO95644 (Uniprot-TrEMBL)
p-13S-NFATC3 [cytosol]ProteinQ12968 (Uniprot-TrEMBL)
p-14S-NFATC2 [cytosol]ProteinQ13469 (Uniprot-TrEMBL)
p-4Y-PIK3AP1 [plasma membrane]ProteinQ6ZUJ8 (Uniprot-TrEMBL)
p-5Y-BLNK [plasma membrane]ProteinQ8WV28 (Uniprot-TrEMBL)
p-6Y-CD19 [plasma membrane]ProteinP15391 (Uniprot-TrEMBL)
p-6Y-SYK [plasma membrane]ProteinP43405 (Uniprot-TrEMBL)
p-BCL10 [plasma membrane]ProteinO95999 (Uniprot-TrEMBL)
p-BCL10ProteinO95999 (Uniprot-TrEMBL)
p-CARMA1 OligomerComplexREACT_119302 (Reactome) The coiled coil (CC) domain of CARMA1 interacts with the CC domain on other CARMA1 molecules to form oligomers of unknown stoichiometry.
p-RasGRP1,3:DAGComplexREACT_118884 (Reactome) RasGRP3 binds diacylglycerol via its C1 domain.
p-S157,S161-NFKBIE [cytosol]ProteinO00221 (Uniprot-TrEMBL)
p-S157,S161-Ub-NFKBIE [cytosol]ProteinO00221 (Uniprot-TrEMBL)
p-S177,S181-IKBKB [cytosol]ProteinO14920 (Uniprot-TrEMBL)
p-S19,S23-NFKBIB [cytosol]ProteinQ15653 (Uniprot-TrEMBL)
p-S19,S23-Ub-NFKBIB [cytosol]ProteinQ15653 (Uniprot-TrEMBL)
p-S32,S36-NFKBIA [cytosol]ProteinP25963 (Uniprot-TrEMBL)
p-S559,S644,S652-CARD11(1-1147) [plasma membrane]ProteinQ9BXL7 (Uniprot-TrEMBL)
p-T133-RASGRP3 [plasma membrane]ProteinQ8IV61 (Uniprot-TrEMBL)
p-T184-RASGRP1 [plasma membrane]ProteinO95267 (Uniprot-TrEMBL)
p-T187-MAP3K7 [plasma membrane]ProteinO43318 (Uniprot-TrEMBL)
p-Y139-DAPP1 [plasma membrane]ProteinQ9UN19 (Uniprot-TrEMBL)
p-Y188,Y199-CD79A [plasma membrane]ProteinP11912 (Uniprot-TrEMBL)
p-Y194,Y195,Y272-SHC1-1(156-583) [plasma membrane]ProteinP29353-3 (Uniprot-TrEMBL)
p-Y196,Y207-CD79B [plasma membrane]ProteinP40259 (Uniprot-TrEMBL) By homology with CD79A (Ig-alpha), CD79B (Ig-beta) is presumed to be phosphorylated on tyrosines 196 and 207.
p-Y223,Y551-BTK [plasma membrane]ProteinQ06187 (Uniprot-TrEMBL)
p-Y239,Y240,Y317-SHC1-2 [plasma membrane]ProteinP29353-2 (Uniprot-TrEMBL)
p-Y753,Y759,Y1217-PLCG2 [plasma membrane]ProteinP16885 (Uniprot-TrEMBL)
p-Y771,Y783-PLCG1 [plasma membrane]ProteinP19174 (Uniprot-TrEMBL)
p21 RAS:GDPComplexREACT_2657 (Reactome)
p21 RAS:GTPComplexREACT_4782 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
26S proteasomemim-catalysisREACT_118617 (Reactome)
ADPArrowREACT_118598 (Reactome)
ADPArrowREACT_118618 (Reactome)
ADPArrowREACT_118689 (Reactome)
ADPArrowREACT_118716 (Reactome)
ADPArrowREACT_118728 (Reactome)
ADPArrowREACT_118733 (Reactome)
ADPArrowREACT_118834 (Reactome)
ATPREACT_118598 (Reactome)
ATPREACT_118618 (Reactome)
ATPREACT_118689 (Reactome)
ATPREACT_118716 (Reactome)
ATPREACT_118728 (Reactome)
ATPREACT_118733 (Reactome)
ATPREACT_118834 (Reactome)
Activated PKC betaArrowREACT_118748 (Reactome)
Activated PKC betamim-catalysisREACT_118598 (Reactome)
Active CalmodulinArrowREACT_12602 (Reactome)
Active CalmodulinREACT_118703 (Reactome)
Active IKK complexArrowREACT_118689 (Reactome)
Active IKK complexmim-catalysisREACT_118618 (Reactome)
Antigen:BCRArrowREACT_118606 (Reactome)
Antigen:BCRREACT_118716 (Reactome)
Antigen:p-BCR:SYKArrowREACT_118749 (Reactome)
Antigen:p-BCR:SYKREACT_118728 (Reactome)
Antigen:p-BCR:p-SYK:p-BLNKArrowREACT_118834 (Reactome)
Antigen:p-BCR:p-SYK:p-BLNKREACT_118566 (Reactome)
Antigen:p-BCR:p-SYK:p-BLNKmim-catalysisREACT_118566 (Reactome)
Antigen:p-BCR:p-SYKArrowREACT_118728 (Reactome)
Antigen:p-BCR:p-SYKREACT_118834 (Reactome)
Antigen:p-BCR:p-SYKmim-catalysisREACT_118728 (Reactome)
Antigen:p-BCR:p-SYKmim-catalysisREACT_118834 (Reactome)
Antigen:p-BCRArrowREACT_118716 (Reactome)
Antigen:p-BCRREACT_118749 (Reactome)
AntigenREACT_118606 (Reactome)
BCAP SignalosomeArrowREACT_118566 (Reactome)
BCAP Signalosomemim-catalysisREACT_118601 (Reactome)
BCRREACT_118606 (Reactome)
BLK(2-505)mim-catalysisREACT_118716 (Reactome)
BLNK (SLP-65) SignalosomeArrowREACT_118566 (Reactome)
BLNK (SLP-65) Signalosomemim-catalysisREACT_118781 (Reactome)
BLNK:GRB2:SOS1:CIN85:CBLREACT_118834 (Reactome)
BTKREACT_118566 (Reactome)
BTKmim-catalysisREACT_118566 (Reactome)
CALM1REACT_12602 (Reactome)
CARMA1 oligomerREACT_118598 (Reactome)
CARMA1:BCL10:MALT1:TAK1:IKKArrowREACT_118585 (Reactome)
CARMA1:BCL10:MALT1:TAK1:IKKREACT_118689 (Reactome)
CARMA1:BCL10:MALT1:TAK1:IKKmim-catalysisREACT_118689 (Reactome)
CARMA1:BCL10:MALT1:TAK1ArrowREACT_118689 (Reactome)
CARMA1:MALT1:BCL10ArrowREACT_118777 (Reactome)
CARMA1:MALT1:BCL10REACT_118585 (Reactome)
CD19 SignalosomeArrowREACT_118566 (Reactome)
CD19 Signalosomemim-catalysisREACT_118828 (Reactome)
CD19:VAV1REACT_118566 (Reactome)
CRAC channelArrowREACT_23904 (Reactome)
CRAC channelmim-catalysisREACT_23967 (Reactome)
Ca2+ArrowREACT_118688 (Reactome)
Ca2+ArrowREACT_118808 (Reactome)
Ca2+ArrowREACT_12074 (Reactome)
Ca2+ArrowREACT_23967 (Reactome)
Ca2+REACT_118688 (Reactome)
Ca2+REACT_118703 (Reactome)
Ca2+REACT_118748 (Reactome)
Ca2+REACT_12074 (Reactome)
Ca2+REACT_12602 (Reactome)
Ca2+REACT_23967 (Reactome)
Calcineurin (CaN)REACT_118703 (Reactome)
Calcineurin:Phosphorylated NFATC1/2/3ArrowREACT_118703 (Reactome)
Calcineurin:Phosphorylated NFATC1/2/3REACT_118664 (Reactome)
Calcineurin:Phosphorylated NFATC1/2/3mim-catalysisREACT_118664 (Reactome)
Cyclophilin A:Cyclosporin ATBarREACT_118664 (Reactome)
DAGArrowREACT_118781 (Reactome)
DAGREACT_118733 (Reactome)
DAGREACT_118748 (Reactome)
DAPP1REACT_118566 (Reactome)
Dephosphorylated NFATC1/2/3ArrowREACT_118664 (Reactome)
FKBP1A:TacrolimusTBarREACT_118664 (Reactome)
FYN(2-537)mim-catalysisREACT_118716 (Reactome)
GRB2-1REACT_118566 (Reactome)
I(1,4,5)P3ArrowREACT_118781 (Reactome)
I(1,4,5)P3ArrowREACT_12074 (Reactome)
I(1,4,5)P3REACT_12008 (Reactome)
IKKA:IKKB:NEMOREACT_118585 (Reactome)
IP3 receptor homotetramerREACT_12008 (Reactome)
IP3 receptor:IP3 complexArrowREACT_12008 (Reactome)
IP3 receptor:IP3 complexmim-catalysisREACT_118808 (Reactome)
IP3 receptor:IP3 complexmim-catalysisREACT_12074 (Reactome)
LYN(2-512)mim-catalysisREACT_118716 (Reactome)
MALT1REACT_118777 (Reactome)
MAP3K7REACT_118585 (Reactome)
NCK1REACT_118566 (Reactome)
NF-kappa-B p50,/p65,/c-Rel:IKBREACT_118618 (Reactome)
NF-kappa-B p50/ p65/c-Rel:p-IKBArrowREACT_118618 (Reactome)
NF-kappa-B p50/ p65/c-Rel:p-IKBREACT_118856 (Reactome)
NF-kappaB p50/p65/c-Rel DimerArrowREACT_118617 (Reactome)
NF-kappaB p50/p65/c-Rel DimerArrowREACT_118705 (Reactome)
NF-kappaB p50/p65/c-Rel DimerREACT_118705 (Reactome)
NF-kappaB p50/p65/c-Rel:ub-p-IKBArrowREACT_118619 (Reactome)
NF-kappaB p50/p65/c-Rel:ub-p-IKBREACT_118617 (Reactome)
NF-kappaB:p-IkB:SCF-betaTrCPArrowREACT_118856 (Reactome)
NF-kappaB:p-IkB:SCF-betaTrCPREACT_118619 (Reactome)
Orai1 dimerREACT_23904 (Reactome)
PI(3,4,5)P3ArrowREACT_118601 (Reactome)
PI(3,4,5)P3ArrowREACT_118828 (Reactome)
PI(4,5)P2REACT_118566 (Reactome)
PI(4,5)P2REACT_118601 (Reactome)
PI(4,5)P2REACT_118781 (Reactome)
PI(4,5)P2REACT_118828 (Reactome)
PIK3AP1REACT_118566 (Reactome)
PIK3CD:PIK3R1REACT_118566 (Reactome)
PIK3CD:PIK3R1mim-catalysisREACT_118566 (Reactome)
PLC gamma1/2REACT_118566 (Reactome)
PRKCBREACT_118748 (Reactome)
PhosphatidylserineREACT_118748 (Reactome)
Phosphorylated NFATC1/2/3REACT_118703 (Reactome)
REACT_118566 (Reactome) Phosphorylated SYK phosphorylates BLNK (SLP-65, Fu et al. 1998, Chiu et al. 2002) and BCAP (inferred from mouse, Okada et al. 2000). Effector molecules are then recruited: phosphoinositol 3-kinase (PI3K), Phospholipase C gamma (predominantly PLC-gamma2 in B cells, Coggeshall et al. 1992), NCK, BAM32, BTK, VAV1, and SHC. The effectors are phosphorylated by SYK and other kinases.
As inferred from chicken DT40 cells and mouse B cells (Okada et al. 2000), phosphorylated BCAP recruits PI3K, which is phosphorylated by a SYK-dependent mechanism (Kuwahara et al. 1996) and produces phosphatidylinositol-3,4,5-trisphosphate (PIP3). PIP3 recruits BAM32 (Marshall et al. 2000) and BTK (de Weers et al. 1994, Baba et al. 2001) via their PH domains. PIP3 also recruits and activates PLC-gamma1 and PLC-gamma2 (Bae et al. 1998). BTK binds phosphorylated BLNK via its SH2 domain (Baba et al. 2001). BTK phosphorylates Phospholipase C gamma-2 (Rodriguez et al. 2001), which activates phospholipase activity (Carter et al. 1991, Roifman and Wang 1992, Kim et al. 2004, Sekiya et al. 2004).
Phosphorylated BLNK recruits PLC gamma, VAV, GRB2, and NCK (Fu and Chan 1997, Fu et al. 1998, Chiu et al. 2002).
SYK phosphorylates SHC which then binds GRB2 (Saxton et al. 1994, Harmer and DeFranco 1997).
CD19 in a stable complex with VAV1 is phosphorylated by Src kinases (inferred from mouse, Xu et al. 2002) and possibly by LYN (inferred from mouse, Fujimoto et al. 2000) in response to BCR activation. Phosphorylated CD19 then binds PI3K (Roifman and Ke 1993, Chalupny et al. 1993, Uckun et al. 1993, Weng et al. 1994, Brooks et al. 2000, Brooks et al. 2004) and can bind PLC-gamma2, which competes with VAV1 for the same binding site on CD19 (Brooks et al. 2000, Brooks et al. 2004).
REACT_118585 (Reactome) TAK1 and the IKK complex are observed to migrate from the cytosol to lipid rafts containing the CARMA1:BCL10:MALT1 (CBM) complex (Sommer et al. 2005, Shinohara et al. 2005 using chicken cells). By analogy with activation of NF-KappaB signaling in T cells, TAK1 in B cells may also be bound to TAB1 and TAB2 or TAB3, which bind K63-conjugated polyubiquitin on a TRAF protein bound to the CBM complex (reviewed in Shinohara et al. 2009).
REACT_118598 (Reactome) CARMA1 is phosphorylated at serines 559, 644, and 652 by Protein Kinase C beta (PKC-beta) (Sommer et al. 2005). CARMA1 is constitutively oligomerized (Tanner et al. 2007) and most CARMA1 in unstimulated cells is cytosolic (Sommer et al. 2005, Tanner et al. 2007), though a portion is constitutively associated with the plasma membrane (Gaide et al. 2002, Sommer et al. 2005). After phosphorylation, CARMA1 is associated with lipid rafts in the plasma membrane (Sommer et al. 2005). Note that some publications refer to CARMA1 with a different N-terminal methionine that is 7 amino acids shorter. In this case the phosphorylated serines are 552, 537, and 645.
REACT_118601 (Reactome) PI3K generates phosphoinositol-3,4,5-trisphosphate (PIP3) from PIP2 after activation of the BCR (Gold et al. 1992, Chantry et al. 1997). Experiments in mice indicate that PI3K associated with BCAP is partly responsible for the activity (Aiba et al. 2008). (PI3K associated with CD19 is also partly responsible (Aiba et al. 2008).)
REACT_118606 (Reactome) Mature, unstimulated B cells express IgM and IgD immunoglobulins on their surfaces (Fu et al. 1974, Fu et al. 1975, reviewed in Kunkel 1975). The immunoglobulins form B cell receptor (BCR) complexes with disulfide-linked heterodimers of Ig-alpha (CD79A) and Ig-beta (CD79B), which have cytoplasmic tails containing immunoreceptor tyrosine-based activation motifs (ITAMs) (van Noesel et al. 1992, Saouaf et al. 1995, inferred from mouse Hombach et al. 1990, Wienands et al. 1990). Upon binding of antigen to the immunoglobulin a chain of phosphorylation events is triggered (Nel et al. 1984, Saouaf et al. 1994, Hata et al. 1994, Saouaf et al. 1995, reviewed in Harwood and Batista 2010).
REACT_118617 (Reactome) Phosphorylated, ubiquitinated IkB is degraded by the proteasome (Miyamoto et al. 1994, Traenckner et al. 1994, Alkalay et al. 1995, DiDonato et al. 1995, Li et al. 1995, Lin et al. 1995, Scherer et al. 1995, Chen et al. 1995). IkB does not dissociate from NF-kB before it is proteolyzed (Miyamoto et al. 1994, Traenckner et al. 1994, DiDonato et al. 1995, Lin et al. 1995).
REACT_118618 (Reactome) Activated IKK complex phosphorylates the I-kappaB component of the cytoplasmic NF-kappaB complex (Zandi et al. 1998, Burke et al. 1999, Heilker et al. 1999). B cells contain I-kappaB-alpha, I-kappaB-beta, and I-kappaB-epsilon (Whiteside et al. 1997, Li and Nabel 1997).
REACT_118619 (Reactome) SKP:Cul:F-box (SCF) complexes containing F-box factors Beta-TrCP1 (BTRCP, E3RSIkappaB) or beta-TrCP2 (BTRCP2, FBXW11, HOS) catalyze the polyubiquitination of IkappaB (Yaron et al. 1998, Fuchs et al. 1999, Suzuki et al. 1999, Tan et al. 1999, Winston et al. 1999, Wu and Ghosh 1999).
REACT_118664 (Reactome) As inferred from mouse (Okamura et al. 2000), calcineurin dephosphorylates NFATC2 at 13 serine residues (Batiuk et al. 1997, Kim et al. 2000). B lymphocytes also contain NFATC2 and NFATC3 which are inferred to undergo dephosphorylation at homologous serines. Dephosphorylation of NFATs exposes a nuclear localization signal which cause NFATs to be imported into the nucleus (Kim et al. 2000). In mouse, Calcineurin is observed to also transit into the nucleus in a complex with NFATs and may remain associated (Shibasaki et al. 1996).
REACT_118688 (Reactome) TRPC1 forms a channel that transports Ca2+ across the plasma membrane. TRPC1 is gated by STIM1 (Ong et al. 2007).
REACT_118689 (Reactome) TAK1 phosphorylates IKK-beta (Wang et al. 2001). As inferred from chicken B cells, the reaction in human B cells may occur when TAK1 and the IKK complex are associated with the CARMA1:BCL10:MALT1 (CBM) complex. During T cell activation TAK1 forms a complex with TAB1 and TAB2, which binds K-63 conjugated polyubiquitin attached to TRAF6 associated with the CBM complex (Sun et al. 2004, reviewed in Shinohara et al. 2009). TRAF6 also polyubiquitinates IKK-gamma in T cells (Zhou et al. 2004). B cells contain functional TRAF6 and TRAF2 (Zhang et al. 2010) so the same mechanism may occur during activation of B cells.
REACT_118703 (Reactome) Calcium activates calcineurin in two ways: binding the regulatory subunit of calcineurin directly and binding calmodulin which then interacts with the catalytic subunit of calcineurin. As inferred from mouse, B lymphocytes contain the R1 regulatory subunit (PPP3R1) and the beta catalytic subunit (PPP3CB).
In the presence of calcium and calcium:calmodulin calcineurin binds phosphorylated and unphosphorylated NFATs at 2 regions in the N-terminus (Luo et al. 1996, Garcia-Cozar et al. 1998, Park et al. 2000, evidence from mouse in Loh et al. 1996 and Wesselborg et al. 1996). Calcineurin also weakly interacts with NFATs in the absence of calcium (Garcia-Cozar et al. 1998).
REACT_118705 (Reactome) Nf-kappaB subunits contain nuclear localization sequences and, in the absence of IkB, are translocated to the nucleus (Bauerle and Baltimore 1988, Blank et al. 1991, Ghosh et al. 2008, Fagerlund et al. 2008). c-Rel binds to importins alpha5, alpha6, and alpha7; RelB binds to importins alpha5 and alpha6; p52 binds importin alpha3, alpha4, alpha5, and alpha6 (Fagerlund et al. 2008)
REACT_118716 (Reactome) The B cell receptor (BCR) comprises an immunoglobulin complexed with a heterodimer of Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29). After immunoglobulin IgM or IgD binds antigen the associated Ig-alpha and Ig-beta are each observed to be phosphorylated at two tyrosine residues in the cytoplasmic immunoreceptor tyrosine-activated motif (ITAM) (Sanchez et al. 1993, Hata et al. 1994, Saouaf et al. 1994, Saouaf et al. 1995). Saouaf et al. (1995) showed that the kinase Blk could phosphorylate both tyrosines of each ITAM and that the kinase SYK specifically bound phosphorylated but not unphosphorylated ITAMs. In mouse the kinase Lyn and other kinases phosphorylate one tyrosine and Syk is believed to phosphorylate the other (Yamanashi et al. 1991, Flaswinkel and Reth 1994, Rolli et al. 2002).
REACT_118728 (Reactome) The SYK protein tyrosine kinase autophosphorylates at tyrosines 131, 323, 348, 352, 525, and 526 (Law et al. 1994, Rowley et al. 1995, Baldock et al. 2000, Irish et al. 2006, Papp et al. 2007, Chen et al. 2008, Tsang et al. 2008). The autophosphorylation increases the kinase activity of SYK. SYK is also phosporylated on additional residues in response to BCR activation (Bohnenberger et al. 2011).
REACT_118733 (Reactome) RasGRP1 and RasGRP3 translocate to the plasma membrane where they bind diacylglycerol (Lorenzo et al. 2001) and are phosphorylated (Teixeira et al. 2003, Zheng et al. 2005). Though RasGRP3 is phosphorylated in vitro and in some cell lines (e.g. Ramos cells) by protein kinase C theta (PKC-theta, Zheng et al. 2005), normal B cells do not contain PKC-theta (Meller et al. 1999). Both Rasgrp1 and Rasgrp3 participate in activating Ras in response to BCR signaling in mouse B cells (Coughlin et al. 2005).
REACT_118748 (Reactome) Human Protein kinase C beta (PKC-beta) is activated by calcium ions, diacylglycerol, and binds phosphatidylserine (Kochs et al. 1991). Experiments in mice have shown that knocking out PKC-beta causes severe defects in B cells, leading to the conclusion that PKC-beta is the predominant signaling PKC in these cells (Leitges et al. 1996, Su et al. 2002, Saijo et al. 2002).
REACT_118749 (Reactome) The SYK protein tyrosine kinase binds specifically to phosphorylated immunoreceptor tyrosine-activated motifs (ITAMs) on Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) (Law et al. 1994, Saouaf et al. 1995, Rowley et al. 1995, Tsang et al. 2008). The binding activates the kinase activity of SYK (Rowley et al. 1995, Tsang et al. 2008).
REACT_118759 (Reactome) The polybasic region of STIM1 interacts with 2 aspartate residues in the C-terminal region of TRPC1 (Zeng et al. 2008, Huang et al. 2006). The STIM1:TRPC1 complex can form a tenary complex with ORAI1 (Ong et al. 2007, Jardin et al. 2008) and ORAI participates in function of STIM1:TRPC1 channels (Cheng et al. 2008, Cheng et al. 2011). As inferred from chicken DT40 cells, TRPC1 (and possibly other TRP channels) participates in store-operated calcium influx during signaling by the B cell receptor (Mori et al. 2002).
REACT_118777 (Reactome) CARMA1 is phosphorylated and recruits BCL10 and MALT1 to the plasma membrane to form the CBM complex (Sommer et al. 2005, Tanner et al. 2007). Evidence from T cells (Jurkat cells) indicates that MALT1 and BCL10 oligomerize to activate the IKK complex (Zhou 2004).
REACT_118781 (Reactome) Phospholipase C gamma (PLC-gamma) is activated by phosphorylation in response to antigen-binding by the B cell receptor (Carter et al. 1991, Roitman and Wang 1992, Rodriguez et al. 2001, Kim et al. 2004, Sekiya et al. 2004). Phospholipase C gamma hydrolyzes phosphatidylinositol-4,5-bisphosphate to yield inositol-1,4,5-trisphosphate and diacylglycerol (Carter et al. 1991, Kim et al. 2004). Human B cells contain both PLC-gamma1 and PLC-gamma2, with PLC-gamma2 predominating (Coggeshall et al. 1992).
REACT_118807 (Reactome) RasGRP1 (Roose et al. 2007) and RasGRP3 (Ohba et al. 2000, Yamashita et al. 2000, Rebhun et al. 2000, Lorenzo et al. 2001) catalyze the exchange of GDP for GTP bound by RAS.
REACT_118808 (Reactome) In the resting state the luminal domain of STIM1 binds Ca2+ ions within the endoplasmic reticulum and this binding prevents dimerization of STIM1 (Luik et al. 2008). Upon depletion of Ca2+ ions from the endoplasmic reticulum, STIM1 is no longer bound to Ca2+ and forms homodimers (Muik et al. 2008, Luik et al. 2008, Park et al. 2009).
REACT_118828 (Reactome) PI3K generates phosphoinositol-3,4,5-trisphosphate (PIP3) from PIP2 after activation of the BCR (Gold et al. 1992). Experiments in mice indicate that PI3K associated with CD19 is partly responsible for the activity (Buhl et al. 1997, Otero et al. 2001, Aiba et al. 2008). (PI3K associated with BCAP is also partly responsible (Aiba et al. 2008).)
REACT_118834 (Reactome) BLNK (SLP-65, BASH) forms a stable complex with GRB2, SOS1, and CIN85 in the cytosol. The complex is recruited to the plasma membrane where activated (phosphorylated) SYK phosphorylates BLNK at tyrosines 72, 84, 96, 178, and 189 (Fu et al. 1998, Chiu et al. 2002, inferred from mouse in Wienands et al. 1998, from chicken in Oellerich et al. 2009). Phosphorylated BLNK serves as a scaffold that binds effector molecules such as Phospholipase C. As inferred from mouse, BLNK interacts with phosphorylated tyrosines on CD79A (Ig-alpha) (Engels et al. 2001, Kabak et al. 2002).
REACT_118856 (Reactome) SKP:Cul:F-box (SCF) complexes containing F-box factors Beta-TrCP1 (BTRCP, E3RSIkappaB) or beta-TrCP2 (BTRCP2, FBXW11, HOS) bind IkappaB (Yaron et al. 1998, Fuchs et al. 1999, Suzuki et al. 1999, Tan et al. 1999, Winston et al. 1999, Wu and Ghosh 1999).
REACT_12008 (Reactome) The IP3 receptor (IP3R) is an IP3-gated calcium channel. It is a large, homotetrameric protein, similar to other calcium channel proteins such as ryanodine. The four subunits form a 'four-leafed clover' structure arranged around the central calcium channel. Binding of ligands such as IP3 results in conformational changes in the receptor's structure that leads to channel opening.
REACT_12074 (Reactome) IP3 promotes the release of intracellular calcium.
REACT_12602 (Reactome) Upon increase in calcium concentration, calmodulin (CaM) is activated by binding to four calcium ions.
REACT_23904 (Reactome) Sustained calcium signalling in lymphocytes and platelets requires the uptake of extracellular calcium when intracellular stores are depleted. The process whereby intracellular calcium depletion stimulates calcium uptake is often referred to as Store-operated calcium entry (SOCE). Store depletion is sensed by stromal interaction molecule 1 (STIM1), which then translocates to the plasma membrane and associates with 2 dimers of Orai1 to form a calcium-release activated calcium (CRAC) channel.
REACT_23967 (Reactome) Activation of Calcium-release-activated (CRAC) channels allows influx of calcium. The Orai component of CRAC is responsible for the selectivity of the channel, while the Stim component is responsible for activation.
RasGRP1/3REACT_118733 (Reactome)
SCF-beta-TrCp1/2ArrowREACT_118619 (Reactome)
SCF-beta-TrCp1/2REACT_118856 (Reactome)
SHC1 p46/p52REACT_118566 (Reactome)
STIM1 DimerArrowREACT_118808 (Reactome)
STIM1 DimerREACT_118759 (Reactome)
STIM1 DimerREACT_23904 (Reactome)
STIM1:CalciumREACT_118808 (Reactome)
STIM1:TRPC1ArrowREACT_118759 (Reactome)
STIM1:TRPC1mim-catalysisREACT_118688 (Reactome)
SYKREACT_118749 (Reactome)
TRPC1REACT_118759 (Reactome)
UbREACT_118619 (Reactome)
VAV1REACT_118566 (Reactome)
p-BCL10REACT_118777 (Reactome)
p-CARMA1 OligomerArrowREACT_118598 (Reactome)
p-CARMA1 OligomerREACT_118777 (Reactome)
p-RasGRP1,3:DAGArrowREACT_118733 (Reactome)
p-RasGRP1,3:DAGmim-catalysisREACT_118807 (Reactome)
p21 RAS:GDPREACT_118807 (Reactome)
p21 RAS:GTPArrowREACT_118807 (Reactome)
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