Apoptosis modulation by HSP70 (Danio rerio)

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InhibitionFAS-LigandDegradation of proteinsSTRESSTNF-alphaMitochondriaProteasomeInhibitionInhibitionDegradation ofIk alpha(activation of NFkB)APOPTOSISActivationApoptosomeInhibitionCELL SURVIVALNF-kBpathwaycasp9fashsp70.3BIDmapk10hsp70.3ripk1lcasp6apaf1CYCScasp2CYCStnfrsf1acasp8casp7faddcasp3anfkb1pdcd8casp8map3k1faddhsp70.3


Description

No description

Comments

GenMAPP notes 
References of HSP70 and inhibition of apoptosis:

1. Garrido C, Schmitt E, Cande C, Vahsen N, Parcellier A, Kroemer G. HSP27 and HSP70: potentially oncogenic apoptosis inhibitors. Cell Cycle. 2003 Nov-Dec;2(6):579-84. PMID: 14512773 [PubMed - in process]
2. Mosser DD, Caron AW, Bourget L, Meriin AB, Sherman MY, Morimoto RI, Massie B. The chaperone function of hsp70 is required for protection against stress-induced apoptosis. Mol Cell Biol. 2000 Oct;20(19):7146-59. PMID: 10982831 [PubMed - indexed for MEDLINE]
3. Saleh A, Srinivasula SM, Balkir L, Robbins PD, Alnemri ES. Negative regulation of the Apaf-1 apoptosome by Hsp70. Nat Cell Biol. 2000 Aug;2(8):476-83. PMID: 10934467 [PubMed - indexed for MEDLINE]
4. Schett G, Steiner CW, Groger M, Winkler S, Graninger W, Smolen J, Xu Q, Steiner G. Activation of Fas inhibits heat-induced activation of HSF1 and up-regulation of hsp70. FASEB J. 1999 May;13(8):833-42. PMID: 10224227 [PubMed - indexed for MEDLINE]
5. Gabai VL, Meriin AB, Yaglom JA, Volloch VZ, Sherman MY. Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging. FEBS Lett. 1998 Oct 30;438(1-2):1-4. Review. PMID: 9821948 [PubMed - indexed for MEDLINE]
6. Jaattela M, Wissing D, Kokholm K, Kallunki T, Egeblad M. Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases.
EMBO J. 1998 Nov 2;17(21):6124-34. PMID: 9799222 [PubMed - indexed for MEDLINE]
7. Orsini F, Migliaccio E, Moroni M, Contursi C, Raker VA, Piccini D, Martin-Padura I, Pelliccia G, Trinei M, Bono M, Puri C, Tacchetti C, Ferrini M, Mannucci R, Nicoletti I, Lanfrancone L, Giorgio M, Pelicci P. The life span determinant p66Shc localizes to mitochondria where it associates with mtHsp70 and regulates trans-membrane potential. J Biol Chem. 2004 Apr 12 [Epub ahead of print] 
PMID: 15078873 [PubMed - as supplied by publisher]
8. Gurbuxani S, Schmitt E, Cande C, Parcellier A, Hammann A, Daugas E, Kouranti I, Spahr C, Pance A, Kroemer G, Garrido C. Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor. Oncogene. 2003 Oct 2;22(43):6669-78. 
PMID: 14555980 [PubMed - indexed for MEDLINE]

GenMAPP remarks 
Right click for info. Adapted from rat by GenMAPP
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP384(r29910) with a 65% conversion rate.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
116850view10:47, 14 May 2021EweitzModified title
98544view20:52, 14 September 2018KhanspersModified description
98540view20:50, 14 September 2018KhanspersModified description
87011view14:44, 15 July 2016MkutmonOntology Term : 'apoptotic cell death pathway' added !
77556view08:03, 24 September 2014Mkutmonlayout
77555view07:59, 24 September 2014Mkutmonadded some gene annotations
72034view13:15, 24 October 2013Mkutmonfixed unconnected lines
68656view05:12, 6 July 2013MaintBotUpdated to 2013 gpml schema
40825view22:18, 1 March 2011MaintBotRemoved redundant pathway information and comments
34211view21:31, 9 December 2009MaintBotAutomatic update of empty xrefs
32345view13:36, 15 August 2009MaintBotFixed text labels
31968view13:07, 14 August 2009MaintBotFixed group labels
31392view20:46, 13 August 2009MaintBotFixed text labels
31104view01:43, 30 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
BIDGeneProduct
CYCSGeneProduct
apaf1GeneProduct58131 (Entrez Gene)
casp2GeneProduct373118 (Entrez Gene)
casp3aGeneProductENSDARG00000017905 (Ensembl)
casp6GeneProduct552927 (Entrez Gene)
casp7GeneProduct553634 (Entrez Gene)
casp8GeneProduct58022 (Entrez Gene)
casp9GeneProduct492763 (Entrez Gene)
faddGeneProduct562317 (Entrez Gene)
fasGeneProduct768248 (Entrez Gene)
hsp70.3GeneProductENSDARG00000021924 (Ensembl)
map3k1GeneProductENSDARG00000088180 (Ensembl)
mapk10GeneProduct569698 (Entrez Gene)
nfkb1GeneProductENSDARG00000020534 (Ensembl)
pdcd8GeneProduct373125 (Entrez Gene) Apoptosis Inducing Factor
ripk1lGeneProduct567460 (Entrez Gene)
tnfrsf1aGeneProduct406471 (Entrez Gene)

Annotated Interactions

No annotated interactions
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