Nuclear receptors (Gallus gallus)

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1Orphan NuclearGlucocorticoid ReceptorActivated ReceptorProgesterone ReceptorOrphan Nuclear ReceptorNR5 SUPERFAMILYRetinoic Acid Receptor RXRNR1 SUPERFAMILYOrphan ReceptorNR3 SUPERFAMILYOxysterols ReceptorNR0 SUPERFAMILYVitamin D3 ReceptorSteroid Hormone ReceptorRetinoic Acid ReceptorNuclear receptor TLXOrphan ReceptorThyroid ReceptorSteroidogenic ReceptorNR4 SUPERFAMILYNuclear Receptor RORReceptorEstrogen ReceptorHepatocyte Nuclear FactorNR2 SUPERFAMILYPeroxisome ProliferatorAndrogen ReceptorCoup Transcription FactorNR1H3NR5A2VDRNR3C1NR2E1THRBPPARGNR2C2NR1D2NR1I2THRBHNF4ANR2F2ESRRBROR1NR2F1RARGRARAESR1NR0B1NR4A2RARBNR4A1RORANR1I3PGRESRRANR5A1RARGARPPARARXRARORCTHRANR1H2PPARDRXRGNR2F6RXRBPPARGESR2


Description

Nuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, these receptors work in concert with other proteins to regulate the expression of specific genes thereby controlling the development, homeostasis, and metabolism of the organism. Nuclear receptors have the ability to directly bind to DNA and regulate the expression of adjacent genes, hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors only happens when a ligand a molecule which affects the receptor's behavior is present. More specifically, ligand binding to a nuclear receptor results in a conformational change in the receptor which in turn activates the receptor resulting in up-regulation of gene expression. A unique property of nuclear receptors which differentiate them from other classes of receptors is their ability to directly interact with and control the expression of genomic DNA. Consequently nuclear receptors play key roles in both embryonic development and adult homeostasis. As discussed in more detail below, nuclear receptors may be classified either according to mechanism or homology. Source: Wikipedia (wikipedia:Nuclear_receptor)

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP170(r21037) with a 65% conversion rate.

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Bibliography

  1. Nagy L, Schule R, Gronemeyer H; ''Twenty years of nuclear receptors: Conference on Nuclear Receptors: from Chromatin to Disease.''; EMBO Rep, 2006 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
117215view09:27, 19 May 2021EweitzModified title
78403view10:25, 7 January 2015MaintBotadded missing graphIds
73651view09:52, 12 February 2014MkutmonModified description
69971view21:13, 11 July 2013MaintBotupdating to 2013 schema
69970view21:13, 11 July 2013MaintBot
67534view11:22, 26 June 2013DdiglesOntology Term : 'transcription factor mediated signaling pathway' added !
41020view22:57, 1 March 2011MaintBotRemoved redundant pathway information and comments
35770view00:11, 13 February 2010AlexanderPico
33941view18:13, 9 December 2009MaintBotAutomatic update of empty xrefs
33501view15:13, 30 November 2009MaintBotRemoved group label
30400view21:09, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ARGeneProduct422165 (Entrez Gene)
ESR1GeneProduct396099 (Entrez Gene)
ESR2GeneProduct395575 (Entrez Gene)
ESRRAGeneProduct
ESRRBGeneProduct771938 (Entrez Gene)
HNF4AGeneProduct419198 (Entrez Gene)
NR0B1GeneProduct395285 (Entrez Gene)
NR1D2GeneProduct396125 (Entrez Gene)
NR1H2GeneProduct
NR1H3GeneProduct395221 (Entrez Gene)
NR1I2GeneProduct
NR1I3GeneProduct395439 (Entrez Gene)
NR2C2GeneProduct395253 (Entrez Gene)
NR2E1GeneProduct396082 (Entrez Gene)
NR2F1GeneProduct
NR2F2GeneProduct386585 (Entrez Gene)
NR2F6GeneProduct474359 (Entrez Gene)
NR3C1GeneProduct416343 (Entrez Gene)
NR4A1GeneProduct
NR4A2GeneProduct424320 (Entrez Gene)
NR5A1GeneProduct395960 (Entrez Gene)
NR5A2GeneProduct395961 (Entrez Gene)
PGRGeneProduct396198 (Entrez Gene)
PPARAGeneProduct374120 (Entrez Gene)
PPARDGeneProduct395479 (Entrez Gene)
PPARGGeneProduct373928 (Entrez Gene)
RARAGeneProduct395213 (Entrez Gene)
RARBGeneProduct396266 (Entrez Gene)
RARGGeneProduct
ROR1GeneProduct395179 (Entrez Gene)
RORAGeneProduct415377 (Entrez Gene)
RORCGeneProduct
RXRAGeneProduct417143 (Entrez Gene)
RXRBGeneProduct
RXRGGeneProduct396231 (Entrez Gene)
THRAGeneProduct396251 (Entrez Gene)
THRBGeneProduct396431 (Entrez Gene)
VDRGeneProduct395988 (Entrez Gene)

Annotated Interactions

No annotated interactions
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