Growth hormone (GH) signaling (Bos taurus)
From WikiPathways
Description
The growth Hormone/Insulin-Like Growth Factor axis is a complex system of ligands, binding protein and receptors which the cells use for communication of growth simulating signal. GH is released from the pituitary and by binding to the GH receptor it stimulates longitudinal growth and has anabolic effects on metabolism. Most of the growth-promoting effects of GH are mediated by IGF-1 which is produced mainly in the liver after GH stimulation. IGF-1 has crucial functions especially for embryonic growth and development. This pathway is primarily studied to understand factors that contribute to growth in bos taurus(Jiang et al.)
Quality Tags
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Ontology Terms
Saving...Pathway Ontology : disease pathway
Disease : familial chylomicronemia syndrome congenital generalized lipodystrophy type 4 congenital generalized lipodystrophy type 3 hyperlipoproteinemia type V familial hyperlipidemia lipodystrophy familial partial lipodystrophy type 1 hyperlipoproteinemia type III congenital generalized lipodystrophy type 1 lipid metabolism disorder familial hypercholesterolemia hypolipoproteinemia familial partial lipodystrophy type 2 familial partial lipodystrophy type 6 acquired generalized lipodystrophy congenital generalized lipodystrophy type 2 familial partial lipodystrophy type 3 familial partial lipodystrophy type 4 familial partial lipodystrophy type 5 hyperlipoproteinemia type IV familial combined hyperlipidemia abetalipoproteinemia Norum disease Tangier disease
Bibliography
- Jiang H, Ge X; ''MEAT SCIENCE AND MUSCLE BIOLOGY SYMPOSIUM--mechanism of growth hormone stimulation of skeletal muscle growth in cattle.''; J Anim Sci, 2014 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name  | Type | Database reference | Comment |
|---|---|---|---|
| GH1 | GeneProduct | 280804 (Entrez Gene)  | |
| GHR | GeneProduct | 280805 (Entrez Gene) | |
| IGF-1 | GeneProduct | 281239 (Entrez Gene) | |
| IGFBP-3 | GeneProduct | 282261 (Entrez Gene) | |
| JAK2 | GeneProduct | 525246 (Entrez Gene) | |
| STAT5b | GeneProduct | 282376 (Entrez Gene) |
Annotated Interactions
No annotated interactions
