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Endpoint Exosome mediated secretion p53 negative feedback G1 arrest (sustained) DNA damage Inhibition of IGF-1/mTOR pathway Target genes G2 arrest (sustained) DNA repair and damage prevention Inhibition of angiogenesis and metastasis Genotoxic stress Stress signals Apoptosis Cell cycle arrest Ddb2 Perp mmu-miR-758-3p Cycs Casp9 Casp8 Ccng1 Fas Mdm2 Trp53 mmu-miR-145a-5p Pidd1 Bai1 mmu-miR-291a-3p mmu-miR-216a-5p Chek2 Rrm2b mmu-miR-195a-5p Pmaip1 mmu-miR-294-3p Igf1 mmu-miR-181a-5p Ccnb2 Atm mmu-miR-503-5p Igfbp3 Gtse1 mmu-miR-217-5p Cdk1 Cdk4 Bid Ccne2 Ppm1d mmu-miR-297a-5p Rrm2 mmu-miR-449a-5p Siah1a Rfwd2 Ei24 Cdkn2a mmu-miR-7b-5p mmu-miR-19b-3p Siah1b mmu-miR-291b-3p Mdm4 Chek1 Bax mmu-miR-103a-3p mmu-miR-18a-5p Ccnb1 Gadd45a mmu-miR-149-5p Steap3 Trp73 Casp3 mmu-miR-17-5p Pten Rchy1 mmu-miR-15a-5p mmu-miR-362-5p Sesn2 Cd82 mmu-miR-20a-5p Zmat3 mmu-miR-34b-5p mmu-miR-9-5p Shisa5 Bbc3 Serpine1 Cdk6 Ccne1 mmu-miR-301b-3p Gadd45b mmu-miR-30e-5p mmu-miR-181b-5p Tsc2 mmu-miR-24-3p Ccng2 mmu-miR-16-5p Ccnd2 Cyct mmu-miR-21-5p Cdk2 Ccnb3 Sesn3 mmu-miR-486-5p Cdkn1a mmu-miR-21a-5p mmu-miR-124-3p mmu-miR-223-3p Apaf1 Atr mmu-miR-425-5p Ccnd1 Thbs1 mmu-miR-295-3p mmu-miR-340-5p Sfn Serpinb5 mmu-miR-302d-3p mmu-miR-1a-3p mmu-miR-122-5p Gadd45g Gm5593 Sesn1 mmu-miR-29b-3p mmu-let-7b-5p Ccnd3 Rprm Gadd45g Gadd45b Gadd45a Igfbp3 Mdm2 Siah1a Siah1b mmu-miR-425-5p mmu-miR-16-5p mmu-miR-17-5p mmu-miR-301b-3p mmu-miR-301b-3p mmu-miR-301b-3p mmu-miR-19b-3p mmu-miR-19b-3p mmu-miR-19b-3p mmu-miR-503-5p mmu-let-7b-5p mmu-miR-19b-3p mmu-miR-340-5p mmu-miR-34b-5p mmu-miR-149-5p mmu-miR-362-5p mmu-miR-15a-5p mmu-miR-362-5p mmu-miR-15a-5p mmu-miR-15a-5p mmu-miR-24-3p
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
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Bibliography
Rieswijk L, Brauers KJ, Coonen ML, van Breda SG, Jennen DG, Kleinjans JC; ''Evaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes.''; Mutagenesis, 2015 PubMed Europe PMC Scholia History
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