Estrogen metabolism (Rattus norvegicus)

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1, 2, 583858874338834337388338467883383884873DNA adductsDNA adductsDNA adductsDNA adductsEstrone sulfateSuperoxideEstradiolUgt1a34-hydroxy-estradiol-sulfateUgt1a3Estradiol-3,4-semiquinoneSult1a1UGT2B7Oxygen2-hydroxy-estradiol-sulfateEstrone-3,4-semiquinone4-Methoxyestrone-3-glucuronideUGT1A9Ugt1a3UGT2B7Ugt1a32-HydroxyestradiolOxygenEstrone-2,3-semiquinoneUgt1a3Ugt1a1Superoxide16a-HydroxyestroneUgt1a3CYP3A4Ugt1a1Estradiol-2,3-semiquinoneUgt1a1Estradiol-17-glucuronideEstrone-3,4-quinone2-hydroxy-estradiol-2-glucuronideUgt1a3Cyp1a1Estrone-17-glucuronideSuperoxideEstradiol sulfateSteUgt1a1ARSDSult1a12-MethoxyestroneUGT2B7ComtComtComtOxygenCyp1a24-hydroxy-estradiol-4-glucuronideUgt1a3Estradiol-2,3-quinoneUgt1a3ComtArseUgt1a2Sts2-Methoxyestrone 3-glucuronide4-hydroxyestradiolCYP3A44-hydroxyestrone-3-glucuronideUGT2B7Nqo1Ugt1a32-Methoxyestradiol-3-glucuronideSuperoxide2-hydroxyestradiol-3-glucuronideOxygenUgt1a1Cyp1a24-MethoxyestradiolUGT1A9GSTM1GSTA1Cyp1a14-Methoxyestradiol-3-glucuronideEstrone2-Hydroxyestrone-3-glucuronideEstrone-3-glucuronideUgt1a1Cyp1b1Estradiol-3,4-quinoneEstrone-2,3-quinone4-hydroxyestrone2-HydroxyestroneSult1a1Nqo14-Hydroxyestradiol-3-glucuronide2-MethoxyestradiolEstradiol-3-glucuronide4-Methoxyestrone


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP697(r30275) with a 75% conversion rate.

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Ontology Terms

 

Bibliography

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  1. Cavalieri EL, Stack DE, Devanesan PD, Todorovic R, Dwivedy I, Higginbotham S, Johansson SL, Patil KD, Gross ML, Gooden JK, Ramanathan R, Cerny RL, Rogan EG; ''Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators.''; Proc Natl Acad Sci U S A, 1997 PubMed Europe PMC Scholia
  2. Lakhani NJ, Sarkar MA, Venitz J, Figg WD; ''2-Methoxyestradiol, a promising anticancer agent.''; Pharmacotherapy, 2003 PubMed Europe PMC Scholia
  3. Bianco NR, Perry G, Smith MA, Templeton DJ, Montano MM; ''Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage.''; Mol Endocrinol, 2003 PubMed Europe PMC Scholia
  4. Shatalova EG, Walther SE, Favorova OO, Rebbeck TR, Blanchard RL; ''Genetic polymorphisms in human SULT1A1 and UGT1A1 genes associate with breast tumor characteristics: a case-series study.''; Breast Cancer Res, 2005 PubMed Europe PMC Scholia
  5. Raftogianis R, Creveling C, Weinshilboum R, Weisz J; ''Estrogen metabolism by conjugation.''; J Natl Cancer Inst Monogr, 2000 PubMed Europe PMC Scholia
  6. Abel EL, Lyon RP, Bammler TK, Verlinde CL, Lau SS, Monks TJ, Eaton DL; ''Estradiol metabolites as isoform-specific inhibitors of human glutathione S-transferases.''; Chem Biol Interact, 2004 PubMed Europe PMC Scholia
  7. Rogan EG, Badawi AF, Devanesan PD, Meza JL, Edney JA, West WW, Higginbotham SM, Cavalieri EL; ''Relative imbalances in estrogen metabolism and conjugation in breast tissue of women with carcinoma: potential biomarkers of susceptibility to cancer.''; Carcinogenesis, 2003 PubMed Europe PMC Scholia
  8. Guillemette C, Belanger A, Lepine J; ''Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview.''; Breast Cancer Res, 2004 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
106958view13:42, 17 September 2019MaintBotHMDB identifier normalization
88025view13:32, 25 July 2016SusanOntology Term : 'steroid metabolic pathway' added !
79795view16:07, 16 April 2015Mkutmonfixed unconnected line
69448view19:06, 8 July 2013MaintBotUpdated to 2013 gpml schema
58974view18:45, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
48282view23:35, 17 May 2012KhanspersUpdating PubChem xrefs
41777view02:42, 2 March 2011MaintBotRemoved redundant pathway information and comments
34145view19:34, 9 December 2009MaintBotAutomatic update of empty xrefs
31899view12:45, 14 August 2009MaintBotFixed group labels
30996view00:58, 30 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
16a-HydroxyestroneMetaboliteHMDB00335 (HMDB)
2-HydroxyestradiolMetaboliteHMDB00338 (HMDB)
2-Hydroxyestrone-3-glucuronideMetabolite
2-HydroxyestroneMetaboliteHMDB00343 (HMDB)
2-Methoxyestradiol-3-glucuronideMetabolite
2-MethoxyestradiolMetaboliteHMDB00405 (HMDB)
2-Methoxyestrone 3-glucuronideMetaboliteHMDB04482 (HMDB)
2-MethoxyestroneMetaboliteHMDB00010 (HMDB)
2-hydroxy-estradiol-2-glucuronideMetabolite
2-hydroxy-estradiol-sulfateMetabolite
2-hydroxyestradiol-3-glucuronideMetabolite
4-Hydroxyestradiol-3-glucuronideMetabolite
4-Methoxyestradiol-3-glucuronideMetabolite
4-MethoxyestradiolMetaboliteHMDB00405 (HMDB)
4-MethoxyestroneMetabolite
4-Methoxyestrone-3-glucuronideMetabolite
4-hydroxy-estradiol-4-glucuronideMetabolite
4-hydroxy-estradiol-sulfateMetabolite
4-hydroxyestradiolMetabolite
4-hydroxyestroneMetabolite
4-hydroxyestrone-3-glucuronideMetabolite
ARSDGeneProduct
ArseGeneProductENSRNOG00000028350 (Ensembl)
CYP3A4GeneProduct
ComtGeneProductENSRNOG00000001889 (Ensembl)
Cyp1a1GeneProductENSRNOG00000019500 (Ensembl)
Cyp1a2GeneProductENSRNOG00000016173 (Ensembl)
Cyp1b1GeneProductENSRNOG00000040287 (Ensembl)
EstradiolMetabolite
Estradiol sulfateMetabolite
Estradiol-17-glucuronideMetabolite
Estradiol-2,3-quinoneMetabolite
Estradiol-2,3-semiquinoneMetabolite
Estradiol-3,4-quinoneMetabolite
Estradiol-3,4-semiquinoneMetabolite
Estradiol-3-glucuronideMetaboliteHMDB06224 (HMDB)
Estrone sulfateMetaboliteHMDB01425 (HMDB)
Estrone-17-glucuronideMetaboliteHMDB04483 (HMDB)
Estrone-2,3-quinoneMetabolite148381 (PubChem-compound)
Estrone-2,3-semiquinoneMetabolite
Estrone-3,4-quinoneMetabolite114862 (PubChem-compound)
Estrone-3,4-semiquinoneMetabolite
Estrone-3-glucuronideMetaboliteHMDB04483 (HMDB)
EstroneMetaboliteHMDB00145 (HMDB)
GSTA1GeneProduct
GSTM1GeneProduct24423 (Entrez Gene)
Nqo1GeneProductENSRNOG00000012772 (Ensembl)
OxygenMetaboliteHMDB01377 (HMDB)
SteGeneProductENSRNOG00000001957 (Ensembl)
StsGeneProduct24800 (Entrez Gene)
Sult1a1GeneProductENSRNOG00000019342 (Ensembl)
SuperoxideMetaboliteHMDB02168 (HMDB)
UGT1A9GeneProduct396552 (Entrez Gene)
UGT2B7GeneProduct
Ugt1a1GeneProduct24861 (Entrez Gene)
Ugt1a2GeneProduct396527 (Entrez Gene)
Ugt1a3GeneProductENSRNOG00000018740 (Ensembl)

Annotated Interactions

No annotated interactions
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