Retinoblastoma gene in cancer (Homo sapiens)

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13425Rb-E2F complexExamples of RB-E2F Complexes inhibiting E2F-driven gene expressionRABIFDNA replication checkpointPOLECDKN1BDNMT1H2AFZDNA replicationSIN3AJNK cascadeDHFRCDC25BCDK2CDC7MAP kinase activityG2/M transition of mitotic cell cycleCCNE1regulation of cyclin-dependent protein kinase activityMCM7RFC4RBBP4WEE1HMGB1CCND3CDC25ASMC3CDKN1ACCND1ANLNRAF1POLD3RPA1MIR21PRMT2SUV39H1PRKDCRBP1M/G1 transition of mitotic cell cycleTFDP1RB1ABL1SAP30TYMSCCNB2HMGB2G1/S transition of mitotic cell cycleNPATCCDC6MYCmitotic cell cycleFANCGTP53BARD1MSH6cell cycle checkpointCCNE2POLE2PRIM1CDKN1BRPA2histone H3-K9 methylationgrowth factor activityCDK1RBBP7HDAC1STMN1PLK4DNA repairRFC3SKP2ABL1KIF4AMDM2CDT1RPA3PCNAPOLA1CCNA2CDC45G1/S transition of mitotic cell cycleRPA1MCM4SMARCA2RRM1SMC2ORC1MAPK13TTKHLTFDNA damage response, signal transduction resulting in induction of apoptosisRRM2CDK4CCNE1MCM6CDK1MCM3RFC5DCKSMC1ACCNB1MCM7E2F1FAF1TOP2ACHEK1RB1RB1TFDP1E2F1RB1SKP2RB1TFDP1E2F2ZNF655RB1RB1MDM2TFDP1E2F1MDM2RBP1HDAC1TFDP1E2F1RB1RB1TFDP1E2F1RB1RB1RB1TP53E2F1E2F3TFDP1G1/S transition of mitotic cell cycleTFDP1E2F1TFDP1E2F2TFDP1E2F3regulation of cyclin-dependent protein kinase activitymitotic spindle organizationTFDP2E2F1TFDP2E2F2TFDP2E2F3RBP1HDAC1TFDP1E2F2RB1RBP1HDAC1TFDP1E2F3RB1RBP1HDAC1TFDP2E2F1RB1RBP1HDAC1TFDP2E2F2RB1RBP1HDAC1TFDP2E2F3RB1RBP1HDAC1TFDP2E2F1RB1E2F2TFDP1RB1E2F3TFDP1RB1CDK6CCND1Examples of RB-E2F Complexes promoting E2F-driven gene expressionRb-E2F complex


Description

Describes the role of retinoblastoma (RB) gene in cancer.

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Bibliography

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  1. Welch PJ, Wang JY; ''A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.''; Cell, 1993 PubMed Europe PMC Scholia
  2. Gabriely G, Wurdinger T, Kesari S, Esau CC, Burchard J, Linsley PS, Krichevsky AM; ''MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators.''; Mol Cell Biol, 2008 PubMed Europe PMC Scholia
  3. Garzon R, Heaphy CE, Havelange V, Fabbri M, Volinia S, Tsao T, Zanesi N, Kornblau SM, Marcucci G, Calin GA, Andreeff M, Croce CM; ''MicroRNA 29b functions in acute myeloid leukemia.''; Blood, 2009 PubMed Europe PMC Scholia
  4. Ji P, Jiang H, Rekhtman K, Bloom J, Ichetovkin M, Pagano M, Zhu L; ''An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant.''; Mol Cell, 2004 PubMed Europe PMC Scholia
  5. Welch PJ, Wang JY; ''Abrogation of retinoblastoma protein function by c-Abl through tyrosine kinase-dependent and -independent mechanisms.''; Mol Cell Biol, 1995 PubMed Europe PMC Scholia
  6. Domínguez R, Famulari A, Vila J; ''[Leukoencephalopathy: the frontier between what is reversible and what is persistent].''; Rev Neurol, 1997 PubMed Europe PMC Scholia
  7. Valeri N, Gasparini P, Braconi C, Paone A, Lovat F, Fabbri M, Sumani KM, Alder H, Amadori D, Patel T, Nuovo GJ, Fishel R, Croce CM; ''MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2).''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
116593view16:31, 8 May 2021EweitzModified title
113796view11:10, 24 November 2020Finterlysmall graphical update
108145view10:34, 29 November 2019FehrhartOntology Term : 'cancer' added !
108144view10:34, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106493view21:43, 4 September 2019KhanspersModified description
105447view04:57, 8 August 2019KhanspersModified description
102997view14:43, 31 January 2019Mkutmonupdated outdated ensembl ids
98748view01:20, 4 October 2018AlexanderPicoModified title
98747view01:20, 4 October 2018AlexanderPicoModified title
98354view05:35, 24 August 2018EgonwUpdated the MIR21 identifier.
87639view08:54, 25 July 2016LindarieswijkOntology Term : 'disease pathway' added !
84651view22:24, 10 March 2016KhanspersQuick edit to datanode annotation or property
80443view05:49, 23 June 2015KhanspersAdded mir29b targeting of CDK6
80434view20:26, 22 June 2015KhanspersAdded mir21 targeting of MSH6
80433view20:17, 22 June 2015KhanspersAdded mir21 targetinf of E2F1
80430view20:00, 22 June 2015KhanspersAdded mir21 targeting of CDC25A
80174view11:06, 16 May 2015EveloModified title
80173view11:01, 16 May 2015EveloModified description
80172view10:44, 16 May 2015EveloModified description
80171view10:40, 16 May 2015EveloModified description
78573view14:50, 7 January 2015MaintBotadded missing graphIds
76353view18:32, 3 July 2014EgonwRemoved database names when no identifier was given.
76335view22:48, 2 July 2014MaintBotchanged pathway node Xrefs
72248view22:23, 29 October 2013MaintBotchanged xrefs from Gene Ontology to WikiPathways
71096view14:30, 4 October 2013Mkutmonconnected lines
70977view04:49, 19 September 2013JYoungrenSpecify description
70976view04:40, 19 September 2013JYoungrenPeriodical save, work in progress
70975view04:30, 19 September 2013JYoungrenPeriodical save, work in progress
70974view04:18, 19 September 2013JYoungrenSpecify description
70973view00:58, 19 September 2013JYoungrenSpecify description
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70962view18:34, 18 September 2013JYoungrenPeriodical save, work in progress
70961view18:23, 18 September 2013JYoungrenPeriodical save, work in progress
70954view20:11, 17 September 2013JYoungrenPeriodical save, work in progress
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70952view19:30, 17 September 2013JYoungrenSpecify description
70934view23:18, 15 September 2013JYoungrenSpecify description
70933view22:39, 15 September 2013JYoungrenPeriodical save, work in progress
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External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABL1GeneProduct25 (Entrez Gene)
ANLNGeneProduct54443 (Entrez Gene)
BARD1GeneProduct580 (Entrez Gene)
CCDC6GeneProduct8030 (Entrez Gene)
CCNA2GeneProduct890 (Entrez Gene)
CCNB1GeneProduct891 (Entrez Gene)
CCNB2GeneProduct9133 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
CCND3GeneProduct896 (Entrez Gene)
CCNE1GeneProduct898 (Entrez Gene)
CCNE2GeneProduct9134 (Entrez Gene)
CDC25AGeneProduct993 (Entrez Gene)
CDC25BGeneProduct994 (Entrez Gene)
CDC45GeneProduct8318 (Entrez Gene)
CDC7GeneProduct8317 (Entrez Gene)
CDK1GeneProduct983 (Entrez Gene)
CDK2GeneProduct1017 (Entrez Gene)
CDK4GeneProduct1019 (Entrez Gene)
CDK6GeneProduct1021 (Entrez Gene)
CDKN1AGeneProduct1026 (Entrez Gene)
CDKN1BGeneProduct1027 (Entrez Gene)
CDT1GeneProduct81620 (Entrez Gene)
CHEK1GeneProduct1111 (Entrez Gene)
DCKGeneProduct1633 (Entrez Gene)
DHFRGeneProduct1719 (Entrez Gene)
DNA damage response, signal transduction resulting in induction of apoptosisPathwayWP707 (WikiPathways)
DNA repairPathwayWP1805 (WikiPathways)
DNA replication checkpointPathway
DNA replicationPathwayWP466 (WikiPathways)
DNMT1GeneProduct1786 (Entrez Gene)
E2F1GeneProduct1869 (Entrez Gene)
E2F2GeneProduct1870 (Entrez Gene)
E2F3GeneProduct1869 (Entrez Gene)
E2F3GeneProduct1871 (Entrez Gene)
FAF1GeneProduct11124 (Entrez Gene)
FANCGGeneProduct2189 (Entrez Gene)
G1/S transition of mitotic cell cyclePathwayWP45 (WikiPathways)
G2/M transition of mitotic cell cyclePathwayWP1859 (WikiPathways)
H2AFZGeneProduct3015 (Entrez Gene)
HDAC1GeneProduct3065 (Entrez Gene)
HLTFGeneProduct6596 (Entrez Gene)
HMGB1GeneProduct3146 (Entrez Gene)
HMGB2GeneProduct3148 (Entrez Gene)
JNK cascadePathway
KIF4AGeneProduct24137 (Entrez Gene)
M/G1 transition of mitotic cell cyclePathway
MAP kinase activityPathwayWP382 (WikiPathways)
MAPK13GeneProduct5603 (Entrez Gene)
MCM3GeneProduct4172 (Entrez Gene)
MCM4GeneProduct4173 (Entrez Gene)
MCM6GeneProduct4175 (Entrez Gene)
MCM7GeneProduct4176 (Entrez Gene)
MDM2GeneProduct4193 (Entrez Gene)
MIR21RnaENSG00000199004 (Ensembl)
MSH6GeneProduct2956 (Entrez Gene)
MYCGeneProduct4609 (Entrez Gene)
NPATGeneProduct4863 (Entrez Gene)
ORC1GeneProduct4998 (Entrez Gene)
PCNAGeneProduct5111 (Entrez Gene)
PLK4GeneProduct10733 (Entrez Gene)
POLA1GeneProduct5422 (Entrez Gene)
POLD3GeneProduct10714 (Entrez Gene)
POLE2GeneProduct5427 (Entrez Gene)
POLEGeneProduct5426 (Entrez Gene)
PRIM1GeneProduct5557 (Entrez Gene)
PRKDCGeneProduct5591 (Entrez Gene)
PRMT2GeneProduct3275 (Entrez Gene)
RABIFGeneProduct5877 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
RB1GeneProduct5925 (Entrez Gene)
RBBP4GeneProduct5928 (Entrez Gene)
RBBP7GeneProduct5931 (Entrez Gene)
RBP1GeneProduct5947 (Entrez Gene)
RFC3GeneProduct5983 (Entrez Gene)
RFC4GeneProduct5984 (Entrez Gene)
RFC5GeneProduct5985 (Entrez Gene)
RPA1GeneProduct6117 (Entrez Gene)
RPA2Protein6118 (Entrez Gene)
RPA3Protein6119 (Entrez Gene)
RRM1GeneProduct6240 (Entrez Gene)
RRM2GeneProduct6241 (Entrez Gene)
SAP30GeneProduct8819 (Entrez Gene)
SIN3AGeneProduct25942 (Entrez Gene)
SKP2GeneProduct6502 (Entrez Gene)
SMARCA2GeneProduct6595 (Entrez Gene)
SMC1AGeneProduct8243 (Entrez Gene)
SMC2GeneProduct10592 (Entrez Gene)
SMC3GeneProduct9126 (Entrez Gene)
STMN1GeneProduct3925 (Entrez Gene)
SUV39H1GeneProduct6839 (Entrez Gene)
TFDP1GeneProduct7027 (Entrez Gene)
TFDP2GeneProduct7029 (Entrez Gene)
TOP2AGeneProduct7153 (Entrez Gene)
TP53GeneProduct7157 (Entrez Gene)
TTKGeneProduct7272 (Entrez Gene)
TYMSGeneProduct7298 (Entrez Gene)
WEE1GeneProduct7465 (Entrez Gene)
ZNF655Protein79027 (Entrez Gene)
cell cycle checkpointPathway
growth factor activityPathway
histone H3-K9 methylationPathway
mitotic cell cyclePathwayWP179 (WikiPathways)
mitotic spindle organizationPathway
regulation of cyclin-dependent protein kinase activityPathway

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2446"
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