Tetrahydrofolate biosynthesis II (Oryza sativa)

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cytosolPiATPABENZUDPPiADPH+7,8-dihydroneopterin3'-triphosphatePiH2OHCOOHADPHCOOHdihydrofolatereductaseATPDHFPYRL-GlndihydroneopterinaldolaseGTPL-GluPiPPiL-GluH2OUDP-GlcATP4-amino-4-deoxychorismatetetrahydrofolatesynthaseCRSM2-amino-4-hydroxy-6-hydroxymethyldihydropteridinediphosphokinaseL-GluTHFPPiATPdihydroneopterinGTP cyclohydrolase I (LOC_OS04G56710.1)dihydropteroatesynthaseNADP+7,8-dihydropteroateNADPHTHF-L-glutamateformate--tetrahydrofolateligase(LOC_OS09G27420.1)2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridinediphosphateglycolaldehydedihydroneopterinphosphateH2OH2OAMPADP


Description

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History

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CompareRevisionActionTimeUserComment
124787view08:53, 11 December 2022EgonwReplaced a RiceCyc identifier with a matching UniProt id
123816view12:11, 16 August 2022EgonwOntology Term : 'classic metabolic pathway' added !
118297view12:14, 26 May 2021EweitzModified title
82104view14:43, 8 September 2015Anweshafixing title, data source, & tagging incomplete pathways
80513view14:49, 25 June 2015AnweshaNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Metabolite
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphateMetaboliteCHEBI:15998 (ChEBI)
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinaseProtein1121789 (Reactome) Facilitates the conversion of 6-hydroxymethyl-dihydropterin to 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate.
4-amino-4-deoxychorismateMetaboliteCHEBI:18198 (ChEBI)
7,8-dihydroneopterin 3'-triphosphateMetaboliteCHEBI:18372 (ChEBI)
7,8-dihydropteroateMetaboliteCHEBI:4581 (ChEBI)
ABENZMetaboliteCHEBI:30753 (ChEBI)
ADPMetaboliteCHEBI:16761 (ChEBI)
AMPMetaboliteCHEBI:16027 (ChEBI)
ATPMetaboliteCHEBI:15422 (ChEBI)
CRSMMetaboliteCHEBI:17333 (ChEBI)
DHFMetaboliteCHEBI:15633 (ChEBI)
GTP cyclohydrolase I (LOC_OS04G56710.1)ProteinLOC_OS04G56710.1 (RiceCyc) Facilitates the conversion of GTP to 7,8-dihydroneopterin 3'-triphosphate.
GTPMetaboliteCHEBI:15996 (ChEBI)
H+MetaboliteCHEBI:15378 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
HCOOHMetaboliteCHEBI:30751 (ChEBI)
L-GlnMetaboliteCHEBI:18050 (ChEBI)
L-GluMetaboliteCHEBI:16015 (ChEBI)
NADP+MetaboliteCHEBI:18009 (ChEBI)
NADPHMetaboliteCHEBI:16474 (ChEBI)
PPiMetaboliteCHEBI:29888 (ChEBI)
PYRMetaboliteCHEBI:32816 (ChEBI)
PiMetaboliteCHEBI:18367 (ChEBI)
THF-L-glutamateMetaboliteCHEBI:27650 (ChEBI)
THFMetaboliteCHEBI:15635 (ChEBI)
UDP-GlcMetaboliteCHEBI:18066 (ChEBI)
UDPMetaboliteCHEBI:17659 (ChEBI)
dihydrofolate reductaseProtein1121824 (Reactome) Facilitates the conversion of 7,8-dihydrofolate to tetrahydrofolate.
dihydroneopterin aldolaseProtein1121856 (Reactome) Facilitates the conversion of dihydro-neo-pterin to 6-hydroxymethyl-dihydropterin.
dihydroneopterin phosphateMetaboliteCHEBI:48954 (ChEBI)
dihydroneopterinMetaboliteCHEBI:17001 (ChEBI)
dihydropteroate synthaseProtein1121951 (Reactome) Facilitates the combination of p-aminobenzoate and 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate to form 7,8-dihydropteroate.
formate--tetrahydrofolate

ligase

(LOC_OS09G27420.1)		ProteinQ0J1E1 (Uniprot-TrEMBL) Catalyzes the convertion of tetrahydrofolate into N10-formyl-THF.
glycolaldehydeMetaboliteCHEBI:17071 (ChEBI)
tetrahydrofolate synthaseProtein1121701 (Reactome) Catalyzes the convertion of tetrahydropteroyl-[gamma-Glu](n) into tetrahydropteroyl-[gamma-Glu](n+1).

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
1119640 (Reactome)
1119912 (Reactome)
1120019 (Reactome) 7,8-dihydrofolate is converted to tetrahydrofolate by enzymatic activity of dihydrofolate reductase.
1120141 (Reactome) Dihydro-neo-pterin is converted to 6-hydroxymethyl-dihydropterin by enzymatic activity of dihydroneopterin aldolase.
1120153 (Reactome)
1120209 (Reactome) 4-amino-4-deoxychorismate is converted to p-aminobenzoate by enzymatic activity of an unknown gene product.
1120495 (Reactome)
1120572 (Reactome) Chorismate is converted to 4-amino-4-deoxychorismate by enzymatic activity of an unknown gene product.
1120715 (Reactome)
1120877 (Reactome)
1120960 (Reactome) Tetrahydrofolate is converted to THF-L-glutamate by enzymatic activity of tetrahydrofolate synthase.
1121346 (Reactome) 7,8-dihydroneopterin 3'-triphosphate is converted to dihydroneopterin phosphate by enzymatic activity of an unknown gene product.
1121366 (Reactome) 7,8-dihydropteroate is converted to 7,8-dihydrofolate by enzymatic activity of an unknown gene product.
1121496 (Reactome) Dihydroneopterin phosphate is converted to dihydro-neo-pterin by enzymatic activity of an unknown gene product.
1121614 (Reactome) GTP is converted to 7,8-dihydroneopterin 3'-triphosphate by enzymatic activity of GTP cyclohydrolase I.
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate1120495 (Reactome)
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphateArrow1119912 (Reactome)
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinasemim-catalysis1119912 (Reactome)
4-amino-4-deoxychorismate1120209 (Reactome)
4-amino-4-deoxychorismateArrow1120572 (Reactome)
7,8-dihydroneopterin 3'-triphosphate1121346 (Reactome)
7,8-dihydroneopterin 3'-triphosphateArrow1121614 (Reactome)
7,8-dihydropteroate1121366 (Reactome)
7,8-dihydropteroateArrow1120495 (Reactome)
ABENZ1120153 (Reactome)
ABENZ1120495 (Reactome)
ABENZArrow1120209 (Reactome)
ADP1120877 (Reactome)
ADPArrow1119640 (Reactome)
ADPArrow1120960 (Reactome)
ADPArrow1121366 (Reactome)
AMPArrow1119912 (Reactome)
ATP1119640 (Reactome)
ATP1119912 (Reactome)
ATP1120960 (Reactome)
ATP1121366 (Reactome)
ATPArrow1120877 (Reactome)
Arrow1119640 (Reactome)
Arrow1120141 (Reactome)
Arrow1120153 (Reactome)
Arrow1120715 (Reactome)
Arrow1120877 (Reactome)
CRSM1120572 (Reactome)
DHF1120019 (Reactome)
DHFArrow1121366 (Reactome)
GTP cyclohydrolase I (LOC_OS04G56710.1)mim-catalysis1121614 (Reactome)
GTP1121614 (Reactome)
H+1120019 (Reactome)
H2O1120715 (Reactome)
H2O1121346 (Reactome)
H2O1121496 (Reactome)
H2O1121614 (Reactome)
HCOOHArrow1120877 (Reactome)
HCOOHArrow1121614 (Reactome)
L-Gln1120572 (Reactome)
L-Glu1119640 (Reactome)
L-Glu1120960 (Reactome)
L-Glu1121366 (Reactome)
L-GluArrow1120572 (Reactome)
NADP+Arrow1120019 (Reactome)
NADPH1120019 (Reactome)
PPiArrow1120495 (Reactome)
PPiArrow1121346 (Reactome)
PYRArrow1120209 (Reactome)
Pi1120877 (Reactome)
PiArrow1119640 (Reactome)
PiArrow1120960 (Reactome)
PiArrow1121366 (Reactome)
PiArrow1121496 (Reactome)
THF-L-glutamateArrow1120960 (Reactome)
THF1120960 (Reactome)
THFArrow1120019 (Reactome)
UDP-Glc1120153 (Reactome)
UDPArrow1120153 (Reactome)
dihydrofolate reductasemim-catalysis1120019 (Reactome)
dihydroneopterin aldolasemim-catalysis1120141 (Reactome)
dihydroneopterin phosphate1121496 (Reactome)
dihydroneopterin phosphateArrow1121346 (Reactome)
dihydroneopterin1120141 (Reactome)
dihydroneopterinArrow1121496 (Reactome)
dihydropteroate synthasemim-catalysis1120495 (Reactome)
formate--tetrahydrofolate

ligase

(LOC_OS09G27420.1)		mim-catalysis1120877 (Reactome)
glycolaldehydeArrow1120141 (Reactome)
tetrahydrofolate synthasemim-catalysis1119640 (Reactome)
tetrahydrofolate synthasemim-catalysis1120960 (Reactome)
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