Methylation pathways (Bos taurus)
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O-methylation
N-methylation
S-methylation
SAM synthesis (co-substrate)
Phosphate
S-Adenosylhomocysteine
PNMT
S-Adenosylmethionine
COMT
NNMT
S-methylated substrate
MAT2A
TPMT
S-Adenosylhomocysteine
S-Adenosylhomocysteine
N-methylated substrate
S-Adenosylmethionine
MAT2B
Phosphate
Substrate
L-Methionine
MAT1A
O-methylated substrate
HNMT
ATP
S-Adenosylmethionine
INMT
Description
No description
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP704(79563)
with a 88.0% conversion rate.
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Quality Tags
Ontology Terms
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Bibliography
Testa B, Kramer SD; ''The biochemistry of drug metabolism--an introduction: part 4. reactions of conjugation and their enzymes.''; Chem Biodivers, 2008
PubMed
Europe PMC
Scholia
Weinshilboum RM; ''Pharmacogenomics: catechol O-methyltransferase to thiopurine S-methyltransferase.''; Cell Mol Neurobiol, 2006
PubMed
Europe PMC
Scholia
History
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Compare
Revision
Action
Time
User
Comment
117555
view
11:18, 21 May 2021
Eweitz
Modified title
105962
view
11:49, 16 August 2019
MaintBot
HMDB identifier normalization
80687
view
15:22, 30 June 2015
Mkutmon
homology conversion
70172
view
00:40, 13 July 2013
AlexanderPico
Modified title
63373
view
23:06, 9 May 2013
MaintBot
Updated to 2013 gpml schema
58821
view
23:19, 20 February 2013
MaintBot
Updated Ensembl and UniProt data source
40545
view
19:31, 1 March 2011
MaintBot
Removed redundant pathway information and comments
33633
view
10:05, 1 December 2009
MaintBot
Removed group label
30561
view
22:03, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
ATP
Metabolite
HMDB00538 (HMDB)
COMT
GeneProduct
ENSBTAG00000019516 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000093010
HNMT
GeneProduct
ENSBTAG00000014432 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000150540
INMT
GeneProduct
ENSBTAG00000001448 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000241644
L-Methionine
Metabolite
HMDB00696 (HMDB)
MAT1A
GeneProduct
ENSBTAG00000005963 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000151224
MAT2A
GeneProduct
ENSBTAG00000020873 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168906
MAT2B
GeneProduct
ENSBTAG00000012350 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000038274
N-methylated substrate
Metabolite
NNMT
GeneProduct
O-methylated substrate
Metabolite
PNMT
GeneProduct
ENSBTAG00000011731 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141744
Phosphate
Metabolite
HMDB01429 (HMDB)
S-Adenosylhomocysteine
Metabolite
HMDB00939 (HMDB)
S-Adenosylmethionine
Metabolite
HMDB01185 (HMDB)
S-methylated substrate
Metabolite
Substrate
Metabolite
TPMT
GeneProduct
ENSBTAG00000019300 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000137364
Annotated Interactions
No annotated interactions
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