Extracellular vesicle-mediated signaling in recipient cells (Bos taurus)

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1Recipient cellEGFRvIIIPackaging of proteinsHost cellExosomeRTK ligandRTKMultivesicular bodiesTGFB3MTORTGFB1WNTPROM1HGFSMAD2APCC-METWNT5ANRASEGFRTSPAN8TGFBR1CTNNB1MAPKERBB2SMAD4FrizzledTGFBR2TGFB1WNT3ADKK4PIK3R5AXIN1AKT1KRASTGFBR3SMAD3HRASRAF1MFGE8TGFATGFB2Mutant KRASPPExosome mediatedsignal transductionAKT1


Description

Protein sorting during formation of multivesicular bodies results in packaging of key molecules in exosomes. Exosomes bound-signaling ligands once released from host cells interacts with the receptors on the recipient cells to induce downstream signaling cascades pivotal in the initiation and progression of cancer. This horizontal transfer of proteomic content of exosomes can mediate signaling pathways including Wnt, PI3K and TGF-beta in recipient cells.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2870(79555) with a 88.0% conversion rate.

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Ontology Terms

 

Bibliography

  1. Gangoda L, Boukouris S, Liem M, Kalra H, Mathivanan S; ''Extracellular vesicles including exosomes are mediators of signal transduction: Are they protective or pathogenic?''; Proteomics, 2014 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
88053view13:47, 25 July 2016SusanOntology Term : 'signaling pathway' added !
80729view15:23, 30 June 2015MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProductENSBTAG00000017636 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207
APCGeneProductENSBTAG00000018852 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:324
AXIN1GeneProductENSBTAG00000016577 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8312
C-METGeneProductENSBTAG00000006161 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4233
CTNNB1GeneProductENSBTAG00000016420 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1499
DKK4GeneProductENSBTAG00000000226 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:27121
EGFRGeneProductENSBTAG00000011628 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1956
ERBB2GeneProductENSBTAG00000021798 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2064
FrizzledGeneProduct
HGFGeneProductENSBTAG00000017664 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3082
HRASGeneProductENSBTAG00000046644 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265
KRASGeneProduct
MAPKGeneProduct
MFGE8GeneProductENSBTAG00000003300 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4240
MTORGeneProductENSBTAG00000015325 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2475
NRASProteinENSBTAG00000046797 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4893
PIK3R5GeneProductENSBTAG00000005978 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23533
PROM1GeneProductENSBTAG00000013736 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8842
RAF1GeneProductENSBTAG00000045748 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894
SMAD2GeneProductENSBTAG00000039916 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4087
SMAD3GeneProductENSBTAG00000012599 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4088
SMAD4GeneProductENSBTAG00000006919 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4089
TGFAGeneProductENSBTAG00000000783 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7039
TGFB1GeneProductENSBTAG00000020457 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7040
TGFB2GeneProductENSBTAG00000005359 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7042
TGFB3GeneProductENSBTAG00000012004 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7043
TGFBR1GeneProductENSBTAG00000018035 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7046
TGFBR2ProteinENSBTAG00000019832 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7048
TGFBR3GeneProductENSBTAG00000024269 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7049
TSPAN8GeneProductENSBTAG00000019425 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7103
WNTGeneProduct
WNT3AGeneProductENSBTAG00000039397 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:89780
WNT5AGeneProductENSBTAG00000020221 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7474

Annotated Interactions

No annotated interactions
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