Vitamin A and carotenoid metabolism (Bos taurus)

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6, 14, 15?RE + dietary lipidsRhodopsin formationDiet?11-cis binding proteinRE + dietary lipidsEnterocyteCytochrome P450 family?gap junction communicationRA-binding proteinsRetinal pigment epithelium specificROL=retinol; RAL=retinaldehyde, RA = retinoic acid, RE = retinyl ester, RPE = retinal pigment epithelium ?RE + dietary lipidsLiver/other organsROL-binding proteinsPPAR pathwaysBlood?Nucleus?Nuclear receptorschylomicronRETSATBetacaroteneABCG8LycopeneRXRBBetacaroteneCYP2E1ADH4CRABP1CYP26B1LRATSCARB1all-trans RetinolVitamin ARARACRABP213,14 dehydroretinalRBP2MAPK1LPLRXRGBetacaroteneCYP26A1Adh1RARGRetinolVitamin AALDH1A2Astaxanthin13,14 dehydro RAALDH1A1BCMO1NPC1L1ALDH1A39-cis-RetinolRPE65RARBDHRS3BetacaroteneRDH8Alpha-CaroteneRetinolVitamin ASULT1A1SCARB1ALDH1A3CanthaxanthinALDH1A2Retinyl esterRDH5ZeaxanthinRetinalVitamin A aldehydeRDH10RLBP1beta 10' apocorotenalRetinyl esterall-transe 4-oxo RAABCG5LRATCd36BCMO1RDH5Beta-CryptoxanthinLuteinSULT2B1BCMO1RBP4RBP74-oxo-Retinoic acidVitamin D3RDH12SDR16C59-cis-RetinalRXRAALDH1A1All-trans-13,14-dihydroretinolAWAT211-cis-RetinolViolaxanthinBCO2RBP111-cis-Retinalall-trans Retinoic acidVitamin A acidDGAT1RDH129-cis-Retinoic acidall-trans Retinal4, 5, 121, 7, 8, 13, 16...5, 92, 3, 10, 11


Description

This pathway is about carotenoid and vitamin A metabolism. The initial version was created by the NuGO focusteam on Carotenoid metabolism. It was used to test a text mining workflow which added some additional entities (see Waagmeester et al. 2009).

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP716(79968) with a 100.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Sies H, Stahl W, Sundquist AR; ''Antioxidant functions of vitamins. Vitamins E and C, beta-carotene, and other carotenoids.''; Ann N Y Acad Sci, 1992 PubMed Europe PMC Scholia
  2. Boosalis MG, Snowdon DA, Tully CL, Gross MD; ''Acute phase response and plasma carotenoid concentrations in older women: findings from the nun study.''; Nutrition, 1996 PubMed Europe PMC Scholia
  3. VandenLangenberg GM, Brady WE, Nebeling LC, Block G, Forman M, Bowen PE, Stacewicz-Sapuntzakis M, Mares-Perlman JA; ''Influence of using different sources of carotenoid data in epidemiologic studies.''; J Am Diet Assoc, 1996 PubMed Europe PMC Scholia
  4. Ruhl CE, Everhart JE; ''Relation of elevated serum alanine aminotransferase activity with iron and antioxidant levels in the United States.''; Gastroenterology, 2003 PubMed Europe PMC Scholia
  5. Khachik F, Beecher GR, Goli MB, Lusby WR, Smith JC Jr; ''Separation and identification of carotenoids and their oxidation products in the extracts of human plasma.''; Anal Chem, 1992 PubMed Europe PMC Scholia
  6. Waagmeester A, Pezik P, Coort S, Tourniaire F, Evelo C, Rebholz-Schuhmann D; ''Pathway enrichment based on text mining and its validation on carotenoid and vitamin A metabolism.''; OMICS, 2009 PubMed Europe PMC Scholia
  7. Torma H, Rollman O, Binderup L, Michaelsson G; ''Vitamin D analogs affect the uptake and metabolism of retinol by human epidermal keratinocytes in culture.''; J Investig Dermatol Symp Proc, 1996 PubMed Europe PMC Scholia
  8. Hidiroglou M, Williams CJ; ''Interrelationships among liposoluble vitamins in ruminants.''; Am J Vet Res, 1986 PubMed Europe PMC Scholia
  9. Micozzi MS, Brown ED, Edwards BK, Bieri JG, Taylor PR, Khachik F, Beecher GR, Smith JC Jr; ''Plasma carotenoid response to chronic intake of selected foods and beta-carotene supplements in men.''; Am J Clin Nutr, 1992 PubMed Europe PMC Scholia
  10. Johansson S, Melhus H; ''Vitamin A antagonizes calcium response to vitamin D in man.''; J Bone Miner Res, 2001 PubMed Europe PMC Scholia
  11. Handelman GJ, Dratz EA, Reay CC, van Kuijk JG; ''Carotenoids in the human macula and whole retina.''; Invest Ophthalmol Vis Sci, 1988 PubMed Europe PMC Scholia
  12. Amir H, Karas M, Giat J, Danilenko M, Levy R, Yermiahu T, Levy J, Sharoni Y; ''Lycopene and 1,25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells.''; Nutr Cancer, 1999 PubMed Europe PMC Scholia
  13. Olmedilla B, Granado F, Blanco I, Rojas-Hidalgo E; ''Seasonal and sex-related variations in six serum carotenoids, retinol, and alpha-tocopherol.''; Am J Clin Nutr, 1994 PubMed Europe PMC Scholia
  14. Bendich A, Olson JA; ''Biological actions of carotenoids.''; FASEB J, 1989 PubMed Europe PMC Scholia
  15. Balmer JE, Blomhoff R; ''Gene expression regulation by retinoic acid.''; J Lipid Res, 2002 PubMed Europe PMC Scholia
  16. Huet F, Semama D, Maingueneau C, Charavel A, Nivelon JL; ''Vitamin A deficiency and nocturnal vision in teenagers with cystic fibrosis.''; Eur J Pediatr, 1997 PubMed Europe PMC Scholia
  17. Czeczuga-Semeniuk E, Wolczynski S, Markiewicz W; ''Preliminary identification of carotenoids in malignant and benign neoplasms of the breast and surrounding fatty tissue.''; Neoplasma, 2003 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
116514view10:50, 7 May 2021EweitzModified title
105994view11:52, 16 August 2019MaintBotHMDB identifier normalization
80754view15:24, 30 June 2015Mkutmonhomology conversion
74435view06:20, 20 April 2014EgonwModified description
74432view06:16, 20 April 2014EgonwFixed a PubMed ID.
71994view11:28, 24 October 2013MkutmonChanged Unknown -> GeneProduct for 29 annotated data nodes
71412view19:01, 17 October 2013MaintBotAutomated update of data sources
70174view00:47, 13 July 2013AlexanderPicoModified title
63361view22:23, 9 May 2013MaintBotUpdated to 2013 gpml schema
58817view23:18, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
48133view05:51, 9 May 2012MaintBotUpdating from human to fix xref duplication
40533view19:30, 1 March 2011MaintBotRemoved redundant pathway information and comments
38716view19:33, 23 September 2010AlexanderPico
33774view00:07, 9 December 2009MaintBotAutomatic update of empty xrefs
32758view23:39, 3 September 2009MaintBotModified categories
30607view22:17, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
11-cis-RetinalMetaboliteHMDB02152 (HMDB)
11-cis-RetinolMetaboliteHMDB06216 (HMDB)
13,14 dehydro RAMetabolite
13,14 dehydroretinalMetabolite
4-oxo-Retinoic acidMetaboliteHMDB06285 (HMDB)
9-cis-RetinalMetaboliteHMDB06218 (HMDB)
9-cis-Retinoic acidMetaboliteHMDB02369 (HMDB)
9-cis-RetinolMetaboliteHMDB06217 (HMDB)
ABCG5GeneProductENSBTAG00000016365 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64240
ABCG8GeneProductENSBTAG00000016366 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64241
ADH4GeneProductENSBTAG00000034139 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:127
ALDH1A1GeneProductENSBTAG00000008103 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:216
ALDH1A2GeneProductENSBTAG00000010119 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8854
ALDH1A3GeneProductENSBTAG00000009125 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:220
AWAT2GeneProductENSBTAG00000012281 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:158835
Adh1GeneProductENSBTAG00000034189 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:124
All-trans-13,14-dihydroretinolMetaboliteHMDB11618 (HMDB)
Alpha-CaroteneMetaboliteHMDB03993 (HMDB)
AstaxanthinMetaboliteHMDB02204 (HMDB)
BCMO1GeneProductENSBTAG00000001026 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:53630
BCO2GeneProductENSBTAG00000034193 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:83875
Beta-CryptoxanthinMetaboliteHMDB02268 (HMDB)
BetacaroteneMetaboliteHMDB00561 (HMDB)
CRABP1GeneProductENSBTAG00000012909 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1381
CRABP2GeneProductENSBTAG00000005716 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1382
CYP26A1GeneProductENSBTAG00000021118 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1592
CYP26B1GeneProductENSBTAG00000012212 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:56603
CYP2E1GeneProductENSBTAG00000018365 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1571
CanthaxanthinMetaboliteHMDB03154 (HMDB)
Cd36GeneProductENSBTAG00000014220 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:948
DGAT1ProteinENSBTAG00000026356 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8694
DHRS3GeneProductENSBTAG00000024493 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9249
LPLGeneProductENSBTAG00000012855 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4023
LRATGeneProductENSBTAG00000017167 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000121207
LuteinMetaboliteHMDB03233 (HMDB)
LycopeneMetaboliteHMDB03000 (HMDB)
MAPK1GeneProductENSBTAG00000010312 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
NPC1L1GeneProductENSBTAG00000044146 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:29881
RARAGeneProductENSBTAG00000012500 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5914
RARBGeneProductENSBTAG00000011518 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5915
RARGGeneProductENSBTAG00000007592 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5916
RBP1GeneProductENSBTAG00000020028 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5947
RBP2GeneProductENSBTAG00000015056 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5948
RBP4GeneProductENSBTAG00000000442 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5950
RBP7GeneProductENSBTAG00000015574 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:116362
RDH10GeneProductENSBTAG00000020143 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:157506
RDH12GeneProductENSBTAG00000012838 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:145226
RDH5GeneProductENSBTAG00000011927 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5959
RDH8GeneProductENSBTAG00000010188 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:50700
RETSATGeneProductENSBTAG00000021934 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54884
RLBP1GeneProductENSBTAG00000033721 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6017
RPE65GeneProductENSBTAG00000020494 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6121
RXRAGeneProductENSBTAG00000017851 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6256
RXRBGeneProductENSBTAG00000000602 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6257
RXRGGeneProductENSBTAG00000016801 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6258
Retinal Vitamin A aldehydeMetaboliteHMDB01358 (HMDB)
Retinol Vitamin AMetaboliteHMDB00305 (HMDB)
Retinyl esterMetaboliteHMDB03598 (HMDB)
SCARB1GeneProductENSBTAG00000014269 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:949
SDR16C5GeneProductENSBTAG00000018570 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:195814
SULT1A1GeneProductENSBTAG00000008635 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6817
SULT2B1GeneProductENSBTAG00000045498 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6820
ViolaxanthinMetaboliteHMDB03101 (HMDB)
Vitamin D3MetaboliteHMDB00876 (HMDB)
ZeaxanthinMetaboliteHMDB02789 (HMDB)
all-trans RetinalMetaboliteHMDB01358 (HMDB)
all-trans Retinoic acid Vitamin A acidMetaboliteHMDB01852 (HMDB)
all-trans Retinol Vitamin AMetaboliteHMDB00305 (HMDB)
all-transe 4-oxo RAMetabolite
beta 10' apocorotenalMetabolite

Annotated Interactions

No annotated interactions
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