Effects of nitric oxide (Bos taurus)

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1, 2HypoxiaIncreasedmitochondrialefficiencyreduced risk ofcarciovascular disease3cGMPsignallingVasodilationanti-inflammatoryeffectsNOS familyIncreased riskof carcinogenesisformation ofnitrosilatingspeciesNOS3Nitric oxideAOX1HBAMBNitrateNOS1COX1INOSCitrullineVItamin CNitriteXDHL-ArginineOxygenDiet


Description

NO (Nitric oxide) is an important signalling molecule with vasodilatory and anti-inflammatory effects, indicating a postive role in reducing hypertension and cardiovascular disease. At the same time, NO is also associated with health risks such as increased risk in carcinogenesis, and hypoxia in infants. It has been suggested that NO can also increase mitochondrial efficiency. NO can be formed from L-Arginine through the classic Arginine-NO-Synthase pathway, or it can be formed directly from dietary nitrite by deoxiginated globins.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP1995(69910) with a 100.0% conversion rate.

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Bibliography

  1. Lundberg JO, Gladwin MT, Ahluwalia A, Benjamin N, Bryan NS, Butler A, Cabrales P, Fago A, Feelisch M, Ford PC, Freeman BA, Frenneaux M, Friedman J, Kelm M, Kevil CG, Kim-Shapiro DB, Kozlov AV, Lancaster JR Jr, Lefer DJ, McColl K, McCurry K, Patel RP, Petersson J, Rassaf T, Reutov VP, Richter-Addo GB, Schechter A, Shiva S, Tsuchiya K, van Faassen EE, Webb AJ, Zuckerbraun BS, Zweier JL, Weitzberg E; ''Nitrate and nitrite in biology, nutrition and therapeutics.''; Nat Chem Biol, 2009 PubMed Europe PMC Scholia
  2. Hord NG, Tang Y, Bryan NS; ''Food sources of nitrates and nitrites: the physiologic context for potential health benefits.''; Am J Clin Nutr, 2009 PubMed Europe PMC Scholia
  3. Larsen FJ, Schiffer TA, Borniquel S, Sahlin K, Ekblom B, Lundberg JO, Weitzberg E; ''Dietary inorganic nitrate improves mitochondrial efficiency in humans.''; Cell Metab, 2011 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
116446view09:51, 7 May 2021EweitzModified title
105948view11:48, 16 August 2019MaintBotHMDB identifier normalization
80761view15:25, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AOX1ProteinENSBTAG00000009725 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138356
COX1GeneProductENSBTAG00000043561 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4512
CitrullineMetaboliteHMDB00904 (HMDB)
HBAGeneProductENSBTAG00000026417 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000206172
INOSGeneProductENSBTAG00000006894 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4843
L-ArginineMetaboliteHMDB00517 (HMDB)
MBGeneProductENSBTAG00000005333 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4151
NOS1GeneProductENSBTAG00000002023 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4842
NOS3GeneProductENSBTAG00000017680 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4846
NitrateMetaboliteHMDB02878 (HMDB)
Nitric oxideMetaboliteHMDB03378 (HMDB)
NitriteMetaboliteHMDB02786 (HMDB)
OxygenMetaboliteHMDB01377 (HMDB)
VItamin CMetaboliteHMDB00044 (HMDB)
XDHGeneProductENSBTAG00000012519 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000158125

Annotated Interactions

No annotated interactions
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