Vitamin B12 metabolism (Bos taurus)

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2453, 45, 85, 91, 150...11, 85, 173, 230, 34711, 234, 284Cofactor conversionCatalysisMicronutrientsStimulationTranscription factorOverarching processNecessary stimulationBindingLEGENDProtein with polymorphismNegative EffectBiomarker forNitrogen CompundsSelenium statusProtein*InhibitionProcess or metabolism involved in Se PathwayOther proteinsFrom intracellular part to the plasmaReactionis composed ofCofactorsConversionMetabolitesEnzymesCleavageSelenoproteinsIntracellularPlasmaLRP2PGE1a-TocopherolThromboxane B2TCN2NFKB2F2-IsoprostaneLipid peroxidationGIFTCN2Prostaglandin metabolismCCL2TCN1Protein tyrosine nitrationPGF2aCCL2PGE2PGE1Thromboxane B2F2-IsoprostanePGE2PGF2aRELAThromboxane A2NFKB1a-TocopherolThromboxane B2CUBNLipoprotein metabolism8-Isoprostaglandin F2aDNA Oxidation8-Isoprostaglandin F2a287, 3105, 42, 69, 80, 117...189223, 32356, 310, 317102, 21131, 83, 107, 147, 257...56, 310, 31714, 83, 107, 345189189154, 229135, 271, 31060, 23829, 83, 92, 107, 108, 200...10317683, 147, 27829, 64, 83, 92, 107...60, 238, 257287, 310135135154, 2291355, 42, 69, 80, 117...12318983, 107, 345MTRMTRRCBRMCEESHMT2MUTMAT1AMMABMM-CoA-H64, 104, 293, 297105, 31916219, 29783, 208, 254162, 34234522865, 95, 104, 171, 220...CBS220, 327NADP+NADHNADP+NADP+MPO187, 273, 341, 347CysteinePLATF7SERPINE1PLATSERPINE1F7PLGPLGF2F2226, 231120, 226120, 226281281281281281281226, 231H2O25,10-Methylene-THF319, 3555-methyl-THF5-methyl-THFCreatinineCreatinine43, 65, 153, 234, 284...92, 24143, 65, 153, 234, 284...92, 241ECSODECSODCTH220THF355NADPHNADPHNADPHNADMTHFR222, 355HomocysteineHomocysteine43, 45, 60, 65, 85...43, 45, 60, 65, 85...SOD1Pyridoxal 5'-phosphatePyridoxal 5'-phosphate43, 132, 153, 154, 24043, 132, 153, 154, 240SerineSerine105, 319105, 319APOA1LDLoxLDLHDL-CAPOBTAGSAA1APOETAGVLDL-TAGHDL/SAAVLDLACTHDL-CHDL/APOA1VLDLAPOA1SCARB1CholesterolHDLLDL/APOBABCA1SAA3LDLRSAA2LDLSAA4oxLDLAPOBVLDL/APOBHDLLDL-CCholesterolACTAPOA1VLDL-TAGLDL-C110, 175252, 337144110, 175, 212117, 238, 242, 273, 323337140, 33731, 238, 274, 337144219, 275144, 219337140, 252, 33714431, 274, 33778144252, 33786, 128117, 238, 242, 273, 323144, 219337337144, 264117, 238, 242, 273, 323144, 264110, 175, 212252, 337252, 337144117, 238, 242, 273, 32333786, 27514033786, 128337AdenosylcobalaminFADMethylcob(III)alaminCob(II)alamin8-OHdGVitamin B12/CobalaminVitamin B12/Cobalamin8-OHdGAdenosylcobalaminMethylcob(III)alaminCob(I)alamin43, 83, 92, 107, 153...104, 232, 293, 297, 345104, 293, 297, 345234, 284, 297, 34543, 83, 92, 106, 107, 153...104176208, 345234, 284, 297, 345208, 345176vitamin DChlorinevitamin DChlorine212212CystathionineSOD2ZincZincNOO3HOClN2OHNO2NO3-NO2116, 171, 187, 34195, 171, 254IFNGD-dimerFibrinHBA1ALBALBIL6IL1BIL1BHbA1cFibrinogenCCL5TNFTNFICAM1IFNGD-dimerCRPINSHBBIR-AIL6CCL5INSFibrinHbA1cFibrinogen99, 153, 33085, 99, 289, 35191, 257352231, 28199, 153, 33056, 74, 85, 113, 150...74, 106, 136231, 281164281, 29656, 85, 15745, 113, 125281, 29691, 257102, 113, 117, 153, 268...147, 19616435285, 9935235274, 85, 113, 150147, 19674, 106, 13655, 7485, 157RiboflavinRiboflavin23, 21223, 212O2 S-AdenosylhomocysteineCbl/IF Methylmalonic acidCbl/TCMethionine Methylmalonic acidCbl/HC S-AdenosylhomocysteineL-Methylmalonyl-CoA S-Adenosylmethionine S-AdenosylmethionineD-Methylmalonyl-CoAMethionineCbl/TC Succinyl-CoA134, 355104, 228, 297, 314, 35583, 162, 208104, 228, 297, 314, 35583, 107, 34583, 162, 20883, 92, 107, 34583, 107, 34565, 73, 355162, 208, 254, 33983, 208134, 355162, 20883, 107, 34565, 73, 355NitrotyrosineONOO-ONOOH123FructosamineFructosamineGlucoseGlucose196136, 352196136, 352Ascorbic acidAscorbic acidAscorbic acid69, 80, 129, 29169, 80, 129, 29169, 80, 129, 291


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HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP1533(79884) with a 80.0% conversion rate.

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  276. Isseroff RR, Ziboh VA, Chapkin RS, Martinez DT; ''Conversion of linoleic acid into arachidonic acid by cultured murine and human keratinocytes.''; J Lipid Res, 1987 PubMed Europe PMC Scholia
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  279. Goriely S, Molle C, Nguyen M, Albarani V, Haddou NO, Lin R, De Wit D, Flamand V, Willems F, Goldman M; ''Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- and TLR3-induced IL-12p35 gene activation.''; Blood, 2006 PubMed Europe PMC Scholia
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  281. Smith WL; ''Cyclooxygenases, peroxide tone and the allure of fish oil.''; Curr Opin Cell Biol, 2005 PubMed Europe PMC Scholia
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  288. May JM, Mendiratta S, Hill KE, Burk RF; ''Reduction of dehydroascorbate to ascorbate by the selenoenzyme thioredoxin reductase.''; J Biol Chem, 1997 PubMed Europe PMC Scholia
  289. Bjørke Monsen AL, Ueland PM, Vollset SE, Guttormsen AB, Markestad T, Solheim E, Refsum H; ''Determinants of cobalamin status in newborns.''; Pediatrics, 2001 PubMed Europe PMC Scholia
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History

View all...
CompareRevisionActionTimeUserComment
120912view06:15, 31 January 2022EgonwReplaced an old HMDB identifier with the current one
117632view11:45, 21 May 2021EweitzModified title
107064view14:15, 17 September 2019MaintBotChEBI identifier normalization
105976view11:50, 16 August 2019MaintBotHMDB identifier normalization
98242view14:13, 14 August 2018EgonwReplace a PubChem SID with a Wikidata ID (which has more links out).
96311view08:58, 8 March 2018MkutmonUpdated homology conversion
80778view15:25, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Methylmalonic acidMetaboliteHMDB00202 (HMDB) Methylmalonate
S-AdenosylhomocysteineMetaboliteHMDB00939 (HMDB)
S-AdenosylmethionineMetaboliteHMDB01185 (HMDB)
Succinyl-CoAMetaboliteHMDB01022 (HMDB)
5,10-Methylene-THFMetaboliteHMDB01533 (HMDB) 5,10-Methylenetetrahydrofolate
5-methyl-THFMetaboliteHMDB01396 (HMDB)
  • 5-methyltetrahydrofolate
  • Predominant food folate
8-Isoprostaglandin F2aMetaboliteHMDB05083 (HMDB)
8-OHdGMetaboliteHMDB03333 (HMDB) 8-Hydroxy-deoxyguanosine
ABCA1ProteinENSBTAG00000020661 (Ensembl)
  • ATP-binding cassette, sub-family A (ABC1), member 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:19
ACTProteinENSBTAG00000048094 (Ensembl)
  • alpha-1-antichymotrypsin
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:12
ALBProteinENSBTAG00000017121 (Ensembl)
  • albumin
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:213
APOA1ProteinENSBTAG00000002258 (Ensembl)
  • apolipoprotein A-I
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:335
APOBProteinENSBTAG00000008505 (Ensembl)
  • apolipoprotein B
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:338
APOEProteinENSBTAG00000010123 (Ensembl)
  • apolipoprotein A-I
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:348
AdenosylcobalaminMetaboliteHMDB02086 (HMDB)
Ascorbic acidMetabolite29073 (ChEBI) Vitamin C
CBRProtein
  • EC 1.16.1.4
  • cob(II)alamin reductase
CBSProteinENSBTAG00000000160 (Ensembl)
  • EC 4.2.1.22
  • cystathionine-beta-synthase
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:875
CCL2GeneProductENSBTAG00000037811 (Ensembl)
  • Monocyte Chemotactic Protein 1
  • CCL2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6347
CCL5ProteinENSBTAG00000007191 (Ensembl)
  • CCL5
  • chemokine (C-C motif) ligand 5
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6352
CRPProteinENSBTAG00000013907 (Ensembl)
  • C-reactive protein, pentraxin-related
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1401
CTHProteinENSBTAG00000014791 (Ensembl)
  • EC 4.4.1.1
  • cystathionase
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1491
CUBNGeneProductENSBTAG00000005072 (Ensembl)
  • cubilin (intrinsic factor-cobalamin receptor)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8029
Cbl/HCMetaboliteHMDB02174 (HMDB) Cobalamin haptocorrin complex
Cbl/IFMetaboliteHMDB02174 (HMDB) Cobalamin Intrinsic factor complex
Cbl/TCMetaboliteHMDB02174 (HMDB) Cobalamin Transcobalamin complex
ChlorineMetaboliteHMDB00492 (HMDB)
CholesterolMetaboliteHMDB00067 (HMDB)
Cob(I)alaminMetaboliteHMDB03429 (HMDB) Reduced cobalamin
Cob(II)alaminMetaboliteHMDB06316 (HMDB) oxidized cobalamin
CreatinineMetaboliteHMDB00562 (HMDB)
  • Creatine anhydride
  • A breakdown product of creatine phosphate in muscle
CystathionineMetaboliteHMDB00099 (HMDB)
CysteineMetaboliteHMDB00574 (HMDB)
D-Methylmalonyl-CoAMetaboliteHMDB01269 (HMDB)
D-dimerProteinhttp://en.wikipedia.org/wiki/Fibrin_degradation_product
DNA OxidationPathway
ECSODProteinENSBTAG00000013980 (Ensembl)
  • EC 1.15.1.1
  • superoxide dismutase 3, extracellular
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6649
F2-IsoprostaneMetabolite53788444 (PubChem-substance)
F2ProteinENSBTAG00000007148 (Ensembl)
  • EC 3.4.21.5
  • coagulation factor II (thrombin)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2147
F7ProteinENSBTAG00000007411 (Ensembl)
  • EC 3.4.21.21
  • coagulation factor VII (serum prothrombin conversion accelerator)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2155
FADMetaboliteHMDB01248 (HMDB) Flavin adenine dinucleotide
FibrinProtein
FibrinogenProtein
FructosamineMetaboliteHMDB02030 (HMDB)
GIFGeneProductENSBTAG00000012057 (Ensembl)
  • gastric intrinsic factor (vitamin B synthesis)
  • Also known as GIF
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2694
GlucoseMetaboliteHMDB00122 (HMDB)
H2O2MetaboliteHMDB03125 (HMDB) Hydrogen peroxide
HBA1Protein
  • hemoglobin, alpha 1
  • HomologyConvert: Multiple homologues found: En:ENSBTAG00000026417;En:ENSBTAG00000026417;
HBBProteinENSBTAG00000038748 (Ensembl)
  • hemoglobin, beta
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3043
HDL-CMetabolite47775 (ChEBI)
  • high-density lipoprotein cholesterol
  • Cholesterol transport
HDL/APOA1Metabolite39025 (ChEBI)
  • high-density lipoprotein
  • ApoA-I is present on the majority of HDL particles and constitutes aprox 70% of the apolipoprotein content of HDL particles
HDL/SAAMetabolite39025 (ChEBI)
  • high-density lipoprotein
  • SAA circulates in plasma as a constituent of high density lipoproteins (HDL).
HDLMetabolite39025 (ChEBI) high-density lipoprotein
HNO2Metabolite25567 (ChEBI) Nitrous acid
HOClMetaboliteHMDB01050 (HMDB) Hypochlorite
HbA1cProtein
  • Glycated hemoglobin
  • http://en.wikipedia.org/wiki/Glycated_hemoglobin
HomocysteineMetaboliteHMDB00742 (HMDB)
ICAM1ProteinENSBTAG00000010303 (Ensembl)
  • soluble intercellular adhesion molecule 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3383
IFNGProteinENSBTAG00000012529 (Ensembl)
  • interferon, gamma
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3458
IL1BProteinENSBTAG00000001321 (Ensembl)
  • interleukin 1, beta
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3553
IL6ProteinENSBTAG00000014921 (Ensembl)
  • interleukin 6 (interferon, beta 2)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3569
INSProteinInsulin
IR-AProteinENSBTAG00000012687 (Ensembl)
  • Insulin receptor
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3643
L-Methylmalonyl-CoAMetaboliteHMDB01269 (HMDB)
LDL-CMetabolite47774 (ChEBI)
  • low-density lipoprotein cholesterol
LDL/APOBMetabolite39026 (ChEBI)
  • low-density lipoprotein
  • LDL particle contains 1 molecule of apo B
LDLMetabolite39026 (ChEBI) low-density lipoprotein
LDLRProteinENSBTAG00000012314 (Ensembl)
  • low density lipoprotein receptor
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3949
LRP2GeneProductENSBTAG00000004555 (Ensembl)
  • Low density lipoprotein receptor-related protein 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4036
Lipid peroxidationPathway
Lipoprotein metabolismPathway
MAT1AProteinENSBTAG00000005963 (Ensembl)
  • EC 2.5.1.6
  • Methionine adenosyltransferase
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4143
MCEEProteinENSBTAG00000035247 (Ensembl)
  • EC 5.1.99.1
  • methylmalonyl CoA epimerase
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84693
MM-CoA-HProtein
  • EC 3.1.2.17
  • (S)-methylmalonyl-CoA hydrolase
MMABProteinENSBTAG00000005178 (Ensembl)
  • EC 2.5.1.17
  • methylmalonic aciduria (cobalamin deficiency) cblB type
  • Also known as ATR
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:326625
MPOProteinENSBTAG00000011616 (Ensembl)
  • EC 1.11.1.7
  • Myeloperoxidase
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4353
MTHFRProteinENSBTAG00000020698 (Ensembl)
  • EC 1.5.1.20
  • 5,10-methylenetetrahydrofolate reductase
  • Homozygous of (MTHFR) 677C-T variant may have enzyme activities up to 50% lower than those without the polymorphism increasing the risk of hyperhomocysteinemia
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4524
MTRProteinENSBTAG00000012251 (Ensembl)
  • EC 2.1.1.13
  • 5-methyltetrahydrofolate-homocysteine methyltransferase
  • Also known as MS
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4548
MTRRProteinENSBTAG00000009401 (Ensembl)
  • EC 1.16.1.8
  • 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4552
MUTProteinENSBTAG00000014272 (Ensembl)
  • EC 5.4.99.2
  • methylmalonyl Coenzyme A mutase
  • Also known as MCM
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4594
MethionineMetaboliteHMDB00696 (HMDB)
Methylcob(III)alaminMetaboliteHMDB02274 (HMDB)
N2OMetabolite17045 (ChEBI)
  • Dinitrogen oxide
  • Nitrous oxide
NADHMetaboliteHMDB01487 (HMDB) Reduced nicotinamide adenine diphosphate
NADMetaboliteHMDB00902 (HMDB) Nicotinamide adenine dinucleotide
NADP+MetaboliteHMDB00217 (HMDB) Nicotinamide adenine dinucleotide phosphate-Oxidized
NADPHMetaboliteHMDB00221 (HMDB) Nicotinamide adenine dinucleotide phosphate-Reduced
NFKB1GeneProductENSBTAG00000020270 (Ensembl)
  • nuclear factor NF-kappa-B p50 subunit
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4790
NFKB2GeneProductENSBTAG00000006017 (Ensembl)
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4791
NO2Metabolite33101 (ChEBI) Nitrogen dioxide
NO3-MetaboliteHMDB02878 (HMDB) Nitrate
NOMetaboliteHMDB03378 (HMDB) Nitric oxide
NitrotyrosineMetaboliteHMDB01904 (HMDB)
O2MetaboliteHMDB02168 (HMDB) Superoxide
O3Metabolite25812 (ChEBI) ozone
ONOO-ONOOHMetaboliteHMDB02179 (HMDB) Peroxynitrite
PGE1MetaboliteHMDB01442 (HMDB) Prostaglandin E1
PGE2MetaboliteHMDB01220 (HMDB) Prostaglandin E2
PGF2aMetaboliteHMDB01139 (HMDB) Prostaglandin F2a
PLATProteinENSBTAG00000001244 (Ensembl)
  • EC 3.4.21.68
  • plasminogen activator, tissue
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5327
PLGProteinENSBTAG00000001271 (Ensembl)
  • EC 3.4.21.7
  • Plasminogen
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5340
Prostaglandin metabolismPathway
Protein tyrosine nitrationPathway
Pyridoxal 5'-phosphateMetaboliteHMDB01491 (HMDB) Vitamin B6
RELAGeneProductENSBTAG00000013895 (Ensembl)
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5970
RiboflavinMetaboliteHMDB00244 (HMDB)
SAA1Proteinserum amyloid A1
SAA2Proteinserum amyloid A2
SAA3Proteinserum amyloid A3 pseudogene
SAA4ProteinENSBTAG00000002963 (Ensembl)
  • serum amyloid A4, constitutive
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6291
SCARB1ProteinENSBTAG00000014269 (Ensembl)
  • scavenger receptor class B, member 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:949
SERPINE1ProteinENSBTAG00000014465 (Ensembl)
  • Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5054
SHMT2ProteinENSBTAG00000031500 (Ensembl)
  • EC 2.1.2.1
  • Serine hydroxymethyltransferase
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6472
SOD1ProteinENSBTAG00000018854 (Ensembl)
  • EC 1.15.1.1
  • superoxide dismutase 1, soluble
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6647
SOD2ProteinENSBTAG00000006523 (Ensembl)
  • EC 1.15.1.1
  • superoxide dismutase 2, mitochondrial
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6648
SerineMetaboliteHMDB00187 (HMDB)
TAGMetabolite17855 (ChEBI)
  • Triglyceride
  • Triacylglycerol
TCN1GeneProductENSBTAG00000020580 (Ensembl)
  • Haptocorrin
  • transcobalamin I (vitamin B12 binding protein, R binder family)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6947
TCN2GeneProductENSBTAG00000002770 (Ensembl)
  • transcobalamin II; macrocytic anemia
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6948
THFMetaboliteHMDB01846 (HMDB) Tetrahydrofolic acid
TNFProteinENSBTAG00000025471 (Ensembl)
  • tumor necrosis factor (TNF superfamily, member 2)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7124
Thromboxane A2MetaboliteHMDB01452 (HMDB)
Thromboxane B2MetaboliteHMDB03252 (HMDB)
VLDL-TAGMetabolite47776 (ChEBI)
  • very-low-density lipoprotein-triglyceride
  • Triglyceride transport
VLDL/APOBMetabolite39027 (ChEBI)
  • very-low-density lipoprotein
  • The VLDL is produced in the liver, contains one molecule of apoB100
VLDLMetabolite39027 (ChEBI) very-low-density lipoprotein
Vitamin B12/CobalaminMetaboliteHMDB02174 (HMDB)
ZincMetaboliteHMDB01303 (HMDB)
a-TocopherolMetaboliteHMDB01893 (HMDB) Vitamin E
oxLDLMetabolite39026 (ChEBI) oxidized low-density lipoprotein
vitamin DMetabolite27300 (ChEBI)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3193"
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