Differentiation of white and brown adipocyte (Bos taurus)

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1, 211White AdipocytePPARGBMP2MPZL2ADIPOQPPARGC1ACIDEAZIC1C/EBPβPRDM16PPARGC1BSMAD9SLC7A10HOXC8SMAD1SMAD9HOXC9HSPB7BMP4C/EBPαPRDM16PRDM16CEBPGBMP7PLAC8OBZNF423EBF3SMAD5Brown AdipocytePreadipocyteVascular progenitorsSMAD5SMAD1C/EBPβ


Description

Development of white versus brown adipocytes (figure from Handbook of Obesity). Transcription factors and nuclear regulators controlling the development of white versus brown adipocytes are shown in the pathway. At the bottom a selection of identified markers of white and brown adipocytes were added (from Nascimento et al).

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2895(79216) with a 90.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Nascimento EB, Boon MR, van Marken Lichtenbelt WD; ''Fat cells gain new identities.''; Sci Transl Med, 2014 PubMed Europe PMC Scholia
  2. George A. Bray, Claude Bouchard; ''Handbook of Obesity (3rd edition)''; CRC Press, 2014

History

View all...
CompareRevisionActionTimeUserComment
116604view09:31, 9 May 2021EweitzOntology Term : 'brown fat cell' added !
116603view09:31, 9 May 2021EweitzOntology Term : 'white fat cell' added !
116470view10:09, 7 May 2021EweitzModified title
87892view12:49, 25 July 2016SusanOntology Term : 'regulatory pathway' added !
80829view15:27, 30 June 2015MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ADIPOQGeneProductENSBTAG00000019813 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000181092
BMP2GeneProductENSBTAG00000005111 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125845
BMP4GeneProductENSBTAG00000003835 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125378
BMP7GeneProductENSBTAG00000015362 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000101144
C/EBPαGeneProduct
C/EBPβGeneProduct
CEBPGGeneProductENSBTAG00000017560 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000153879
CIDEAGeneProductENSBTAG00000047609 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000176194
EBF3GeneProductENSBTAG00000008272 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108001
HOXC8GeneProductENSBTAG00000012149 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000037965
HOXC9GeneProductENSBTAG00000005606 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000180806
HSPB7GeneProductENSBTAG00000010940 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000173641
MPZL2GeneProductENSBTAG00000033510 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000149573
OBGeneProductENSBTAG00000014911 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000174697
PLAC8GeneProductENSBTAG00000031750 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000145287
PPARGC1AGeneProductENSBTAG00000017024 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000109819
PPARGC1BGeneProductENSBTAG00000012943 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000155846
PPARGGeneProductENSBTAG00000001333 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132170
PRDM16GeneProductENSBTAG00000018965 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000142611
SLC7A10GeneProductENSBTAG00000046544 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130876
SMAD1GeneProductENSBTAG00000002835 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000170365
SMAD5GeneProductENSBTAG00000021772 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113658
SMAD9GeneProductENSBTAG00000007589 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000120693
ZIC1GeneProductENSBTAG00000014751 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000152977
ZNF423GeneProductENSBTAG00000017397 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000102935

Annotated Interactions

No annotated interactions
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