Senescence and autophagy in cancer (Bos taurus)

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111552, 43, 4AUTOPHAGOSOMESERPINE1SH3GLB1ATG13ING2CDKN2ACDKN1BIL6PIP3(16:0/16:0)SLC39A4GeneProductATG5IL1AIGF-IPLAUbcl-xLMAP1LC3BMAP2K3ATG4CCL3C/EBP-betaATG14CREG1ATG7COL3A1IGFBP5COL10A1RB1CC1CXCL20GABARAPL1ATG5ATG6ATG11MAP1LC3CIFI16PLATMLST8ATG17TNFSF15ATG7VTNSLC39A1CDKN1AFKBP8IFNGINHBAIL3THBS1IL6RCOL1A1GABARAPMAP2K1E2F1MIR29CPI3K?IL24UVRAGING1SERPINB2GSK3BAMBRA1LAMP1ATG12MIR29B1MTORBECN1TGFB1INSRB1PIK3C3SLC39A3CDKN2ACDKN1ACDKN1AHMGA1IRF5GABARAPL2ULK1SQSTM1CDKN2AMAP2K3GeneProductSPARCMMP14LAMP2MIR29B1IL1BMAPK14SRCpkb?ATG3?CDKN1AMAPK1ISREIGFBP3IGF1RBMI1MAP1LC3ABRAFCDKN2AIRF1IRF7PCNAGRO1IL6FN1CDKN2AKMT2AMIR29B2IL6STGASJUNCDKN2AGSNRAF1RNASELCDKN2AMGC138057CXCL14BCL2MMP-3CDC25BCD44CDKN1AMDM2SMAD3SMAD4PIK3C3MIR29CATG16L1TP53RSL1D1PTENHRASCXCL8BMP2AKT1S1CDKN2ASLC39A2GAD45AIGFBP7MIR29B2MIR29C


Description

Senescense and Autophagy Pathways in Cancer

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP615(80451) with a 82.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Kuilman T, Michaloglou C, Vredeveld LC, Douma S, van Doorn R, Desmet CJ, Aarden LA, Mooi WJ, Peeper DS; ''Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network.''; Cell, 2008 PubMed Europe PMC Scholia
  2. Garzon R, Heaphy CE, Havelange V, Fabbri M, Volinia S, Tsao T, Zanesi N, Kornblau SM, Marcucci G, Calin GA, Andreeff M, Croce CM; ''MicroRNA 29b functions in acute myeloid leukemia.''; Blood, 2009 PubMed Europe PMC Scholia
  3. Sengupta S, den Boon JA, Chen IH, Newton MA, Stanhope SA, Cheng YJ, Chen CJ, Hildesheim A, Sugden B, Ahlquist P; ''MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins.''; Proc Natl Acad Sci U S A, 2008 PubMed Europe PMC Scholia
  4. Wang C, Bian Z, Wei D, Zhang JG; ''miR-29b regulates migration of human breast cancer cells.''; Mol Cell Biochem, 2011 PubMed Europe PMC Scholia
  5. Zhao JJ, Lin J, Lwin T, Yang H, Guo J, Kong W, Dessureault S, Moscinski LC, Rezania D, Dalton WS, Sotomayor E, Tao J, Cheng JQ; ''microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma.''; Blood, 2010 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
117600view11:37, 21 May 2021EweitzModified title
106001view11:52, 16 August 2019MaintBotHMDB identifier normalization
81192view13:54, 3 August 2015Mkutmonfixed unconnected lines
80840view15:28, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
?GeneProduct
AKT1S1GeneProductENSBTAG00000005763 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000204673
AMBRA1GeneProductENSBTAG00000004282 (Ensembl)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55626
ATG11GeneProduct
ATG12GeneProductENSBTAG00000017525 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9140
ATG13GeneProductENSBTAG00000017325 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000175224
ATG14GeneProductENSBTAG00000010795 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:22863
ATG16L1GeneProductENSBTAG00000003928 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000085978
ATG17GeneProduct
ATG3GeneProductENSBTAG00000009084 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64422
ATG4GeneProduct
ATG5GeneProductENSBTAG00000005400 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9474
ATG6GeneProduct
ATG7GeneProductENSBTAG00000035827 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10533
BCL2GeneProductENSBTAG00000019302 (Ensembl)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:596
BECN1GeneProductENSBTAG00000019914 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8678
BMI1GeneProduct
  • ARF
  • HomologyConvert: Multiple homologues found: En:ENSBTAG00000015584;En:ENSBTAG00000015584;
BMP2GeneProductENSBTAG00000005111 (Ensembl)
  • tPA
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:650
BRAFGeneProductENSBTAG00000021761 (Ensembl)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:673
C/EBP-betaGeneProduct
CCL3GeneProduct
CD44GeneProductENSBTAG00000011578 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:960
CDC25BGeneProductENSBTAG00000008436 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:994
CDKN1AGeneProductENSBTAG00000008353 (Ensembl)
  • P21/CIP1/WAF1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1026
CDKN1BGeneProductENSBTAG00000018254 (Ensembl)
  • P27/KIP
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1027
CDKN2AGeneProductENSBTAG00000034220 (Ensembl)
  • ARF
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1029
COL10A1GeneProductENSBTAG00000003078 (Ensembl)
  • MKK3
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1300
COL1A1GeneProductENSBTAG00000013103 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1277
COL3A1GeneProductENSBTAG00000021466 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1281
CREG1GeneProductENSBTAG00000008931 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8804
CXCL14GeneProductENSBTAG00000006694 (Ensembl)
  • BRAK
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9547
CXCL20GeneProduct
CXCL8GeneProductENSBTAG00000019716 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3576
E2F1GeneProductENSBTAG00000003971 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1869
FKBP8GeneProductENSBTAG00000045585 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105701
FN1GeneProductENSBTAG00000008300 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2335
GABARAPGeneProductENSBTAG00000014883 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11337
GABARAPL1GeneProductENSBTAG00000011765 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23710
GABARAPL2GeneProductENSBTAG00000006550 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11345
GAD45AGeneProduct
GASTFBSDNA regulatory element
GRO1GeneProductENSBTAG00000037558 (Ensembl)
  • GROa
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2919
GSK3BGeneProductENSBTAG00000048057 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2932
GSNGeneProductENSBTAG00000019915 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2934
GeneProductGeneProduct
HMGA1GeneProductENSBTAG00000034529 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3159
HRASGeneProductENSBTAG00000046644 (Ensembl)
  • H-RAS
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265
IFI16GeneProductENSBTAG00000011511 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3428
IFNGGeneProductENSBTAG00000012529 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3458
IGF-IGeneProductENSBTAG00000011082 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3479
IGF1RGeneProductENSBTAG00000021527 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3480
IGFBP3GeneProductENSBTAG00000003994 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3486
IGFBP5GeneProductENSBTAG00000007062 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3488
IGFBP7GeneProductENSBTAG00000019368 (Ensembl)
  • ARF
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3490
IL1AGeneProductENSBTAG00000010349 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3552
IL1BGeneProductENSBTAG00000001321 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3553
IL24GeneProductENSBTAG00000007851 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11009
IL3GeneProduct
IL6GeneProductENSBTAG00000014921 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3569
IL6GeneProductENSBTAG00000046456 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3456
IL6RGeneProductENSBTAG00000018474 (Ensembl)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3570
IL6STGeneProductENSBTAG00000017745 (Ensembl)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3572
ING1GeneProductENSBTAG00000025211 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3621
ING2GeneProductENSBTAG00000047706 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3622
INHBAGeneProductENSBTAG00000002912 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3624
INSGeneProductBRAK
IRF1GeneProductENSBTAG00000031231 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3659
IRF5GeneProductENSBTAG00000004989 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3663
IRF7GeneProductENSBTAG00000047680 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3665
ISRETFBSDNA regulatory element
JUNGeneProductENSBTAG00000004037 (Ensembl)
  • P21/CIP1/WAF1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725
KMT2AGeneProductENSBTAG00000018093 (Ensembl)
  • ARF
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4297
LAMP1GeneProductENSBTAG00000010242 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3916
LAMP2GeneProductENSBTAG00000007399 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3920
MAP1LC3AGeneProductENSBTAG00000006135 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84557
MAP1LC3BGeneProductENSBTAG00000011632 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:81631
MAP1LC3CGeneProductENSBTAG00000012462 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:440738
MAP2K1GeneProductENSBTAG00000033983 (Ensembl)
  • MEK
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
MAP2K3GeneProductENSBTAG00000010576 (Ensembl)
  • MEK6
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5606
MAPK14GeneProductENSBTAG00000020783 (Ensembl)
  • P38a
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432
MAPK1GeneProductENSBTAG00000010312 (Ensembl)
  • ERK
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
MDM2GeneProductENSBTAG00000010422 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4193
MGC138057GeneProductENSBTAG00000038117 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:83734
MIR29B1Rna
MIR29B2Rna
MIR29CRna
MLST8GeneProductENSBTAG00000009928 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000167965
MMP-3GeneProduct
MMP14GeneProductENSBTAG00000014824 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4323
MTORGeneProductENSBTAG00000015325 (Ensembl)
  • mTOR
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2475
PCNAGeneProductENSBTAG00000006065 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5111
PI3K?GeneProduct
PIK3C3GeneProductENSBTAG00000026290 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000078142
PIP3(16:0/16:0)MetaboliteHMDB10147 (HMDB)
PLATGeneProductENSBTAG00000001244 (Ensembl)
  • tPA
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5327
PLAUGeneProductENSBTAG00000005947 (Ensembl)
  • uPA
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5328
PTENGeneProductENSBTAG00000009498 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5728
RAF1GeneProductENSBTAG00000045748 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894
RB1CC1GeneProductENSBTAG00000000878 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000023287
RB1GeneProductENSBTAG00000006640 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5925
RNASELGeneProductENSBTAG00000009091 (Ensembl)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6041
RSL1D1GeneProductENSBTAG00000014588 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:26156
SERPINB2GeneProductENSBTAG00000023198 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5055
SERPINE1GeneProductENSBTAG00000014465 (Ensembl)
  • PAI1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5054
SH3GLB1GeneProductENSBTAG00000031171 (Ensembl)
  • BIF1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51100
SLC39A1GeneProductENSBTAG00000011284 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:27173
SLC39A2GeneProductENSBTAG00000000936 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:29986
SLC39A3GeneProductENSBTAG00000017706 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:29985
SLC39A4GeneProductENSBTAG00000046026 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55630
SMAD3GeneProductENSBTAG00000012599 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4088
SMAD4GeneProductENSBTAG00000006919 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4089
SPARCGeneProductENSBTAG00000014835 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6678
SQSTM1GeneProductENSBTAG00000015591 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8878
SRCGeneProductENSBTAG00000008938 (Ensembl)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714
TGFB1GeneProductENSBTAG00000020457 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7040
THBS1GeneProductENSBTAG00000002006 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7057
TNFSF15GeneProductENSBTAG00000018069 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9966
TP53GeneProductENSBTAG00000001069 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7157
ULK1GeneProductENSBTAG00000012987 (Ensembl)
  • ATG1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8408
UVRAGGeneProductENSBTAG00000016355 (Ensembl)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7405
VTNGeneProductENSBTAG00000016151 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7448
bcl-xLGeneProduct
pkb?GeneProduct

Annotated Interactions

No annotated interactions
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