O-linked glycosylation (Homo sapiens)

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2, 2126, 27145, 17, 277, 9, 123, 16815, 19, 23, 3041, 16, 2086, 13, 18, 22, 24...1011Golgi lumenendoplasmic reticulum lumenCore 5 mucinsCore 3 mucinsB4GALT5CMP-Neu5AcO-fuc-proteinsUDPUDP-Galextended Core 6mucinsUDP-GalNAcCMP-Neu5AcCMPPOFUT2 substratesGALNT:COSMCUDP-GlcNAcCMP-Neu5AcUDPCore 6 mucinsCore 7 mucinsCMPC1GALT1 UDPC1GALT1:COSMCST6GALNAC3/4UDP-GalSialyl-2,3 TantigensUDP-GalCore 2 mucinsglc-fuc-proteinsCMP-Neu5AcCore 8 mucinsTn antigensCMPUDP-GlcNAcST6GAL1MucinsCMPCMP-Neu5AcC1GALT1C1 B3GNTsDisialyl T antigensUDP-GalNAcCore 1 mucinsST6GALNAC2POFUT2GCNT3B3GALTLSialyl-2,6 TantigensSialyl Tn antigensCore 4 mucinsUDPUDPST3GAL1-4C1GALT1C1 UDPGCNTs


Description

O-glycosylation is an important post-translational modification (PTM) required for correct functioning of many proteins (Van den Steen et al. 1998, Moremen et al. 2012). The O-glycosylation of proteins containing thrombospondin type 1 repeat (TSR) domains and O-glycosylation of mucins are currently described here. Source:Reactome.

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Bibliography

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  45. Inamori K, Willer T, Hara Y, Venzke D, Anderson ME, Clarke NF, Guicheney P, Bönnemann CG, Moore SA, Campbell KP.; ''Endogenous glucuronyltransferase activity of LARGE or LARGE2 required for functional modification of α-dystroglycan in cells and tissues.''; PubMed Europe PMC Scholia
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  48. Togayachi A, Akashima T, Ookubo R, Kudo T, Nishihara S, Iwasaki H, Natsume A, Mio H, Inokuchi J, Irimura T, Sasaki K, Narimatsu H.; ''Molecular cloning and characterization of UDP-GlcNAc:lactosylceramide beta 1,3-N-acetylglucosaminyltransferase (beta 3Gn-T5), an essential enzyme for the expression of HNK-1 and Lewis X epitopes on glycolipids.''; PubMed Europe PMC Scholia
  49. Di Costanzo S, Balasubramanian A, Pond HL, Rozkalne A, Pantaleoni C, Saredi S, Gupta VA, Sunu CM, Yu TW, Kang PB, Salih MA, Mora M, Gussoni E, Walsh CA, Manzini MC.; ''POMK mutations disrupt muscle development leading to a spectrum of neuromuscular presentations.''; PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
114867view16:37, 25 January 2021ReactomeTeamReactome version 75
113313view11:38, 2 November 2020ReactomeTeamReactome version 74
112524view15:48, 9 October 2020ReactomeTeamReactome version 73
101436view11:31, 1 November 2018ReactomeTeamreactome version 66
100975view21:08, 31 October 2018ReactomeTeamreactome version 65
100512view19:42, 31 October 2018ReactomeTeamreactome version 64
100058view16:26, 31 October 2018ReactomeTeamreactome version 63
99610view14:59, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
93999view13:50, 16 August 2017ReactomeTeamreactome version 61
93608view11:28, 9 August 2017ReactomeTeamreactome version 61
88081view09:08, 26 July 2016RyanmillerOntology Term : 'peptide and protein metabolic process' added !
88080view09:07, 26 July 2016RyanmillerOntology Term : 'classic metabolic pathway' added !
86717view09:24, 11 July 2016ReactomeTeamreactome version 56
83262view10:34, 18 November 2015ReactomeTeamVersion54
81374view12:54, 21 August 2015ReactomeTeamNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
B3GALTLProteinQ6Y288 (Uniprot-TrEMBL)
B3GNTsR-HSA-916814 (Reactome)
B4GALT5R-HSA-2901790 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
C1GALT1 ProteinQ9NS00 (Uniprot-TrEMBL)
C1GALT1:COSMCComplexR-HSA-1964504 (Reactome)
C1GALT1C1 ProteinQ96EU7 (Uniprot-TrEMBL)
CMP-Neu5AcMetaboliteCHEBI:16556 (ChEBI)
CMPMetaboliteCHEBI:17361 (ChEBI)
Core 1 mucinsR-HSA-1462240 (Reactome)
Core 2 mucinsR-HSA-1462066 (Reactome)
Core 3 mucinsR-HSA-1462159 (Reactome)
Core 4 mucinsR-HSA-1462144 (Reactome)
Core 5 mucinsR-HSA-1462179 (Reactome)
Core 6 mucinsR-HSA-1462353 (Reactome)
Core 7 mucinsR-HSA-1462341 (Reactome)
Core 8 mucinsR-HSA-1462115 (Reactome)
Disialyl T antigensR-HSA-1463507 (Reactome)
GALNT:COSMCComplexR-HSA-914019 (Reactome)
GCNT3ProteinO95395 (Uniprot-TrEMBL)
GCNTsR-HSA-914009 (Reactome)
MucinsR-HSA-913666 (Reactome)
O-fuc-proteinsR-HSA-5173164 (Reactome)
POFUT2 substratesR-HSA-5173014 (Reactome)
POFUT2ProteinQ9Y2G5 (Uniprot-TrEMBL)
ST3GAL1-4R-HSA-981491 (Reactome)
ST6GAL1ProteinP15907 (Uniprot-TrEMBL)
ST6GALNAC2ProteinQ9UJ37 (Uniprot-TrEMBL)
ST6GALNAC3/4R-HSA-981824 (Reactome)
Sialyl Tn antigensR-HSA-1463504 (Reactome)
Sialyl-2,3 T antigensR-HSA-1463569 (Reactome)
Sialyl-2,6 T antigensR-HSA-1463568 (Reactome)
Tn antigensR-HSA-913659 (Reactome)
UDP-GalMetaboliteCHEBI:18307 (ChEBI)
UDP-GalNAcMetaboliteCHEBI:16650 (ChEBI)
UDP-GlcNAcMetaboliteCHEBI:16264 (ChEBI)
UDPMetaboliteCHEBI:17659 (ChEBI)
extended Core 6 mucinsR-HSA-1967037 (Reactome)
glc-fuc-proteinsR-HSA-5173276 (Reactome)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
B3GALTLmim-catalysisR-HSA-5173005 (Reactome)
B3GNTsmim-catalysisR-HSA-914010 (Reactome)
B4GALT5mim-catalysisR-HSA-1964501 (Reactome)
C1GALT1:COSMCmim-catalysisR-HSA-1964505 (Reactome)
CMP-Neu5AcR-HSA-977071 (Reactome)
CMP-Neu5AcR-HSA-977228 (Reactome)
CMP-Neu5AcR-HSA-981497 (Reactome)
CMP-Neu5AcR-HSA-981809 (Reactome)
CMP-Neu5AcR-HSA-981814 (Reactome)
CMPArrowR-HSA-977071 (Reactome)
CMPArrowR-HSA-977228 (Reactome)
CMPArrowR-HSA-981497 (Reactome)
CMPArrowR-HSA-981809 (Reactome)
CMPArrowR-HSA-981814 (Reactome)
Core 1 mucinsArrowR-HSA-1964505 (Reactome)
Core 1 mucinsR-HSA-914012 (Reactome)
Core 1 mucinsR-HSA-977228 (Reactome)
Core 1 mucinsR-HSA-981497 (Reactome)
Core 1 mucinsR-HSA-981814 (Reactome)
Core 2 mucinsArrowR-HSA-914012 (Reactome)
Core 3 mucinsArrowR-HSA-914010 (Reactome)
Core 3 mucinsR-HSA-914018 (Reactome)
Core 4 mucinsArrowR-HSA-914018 (Reactome)
Core 5 mucinsArrowR-HSA-914005 (Reactome)
Core 6 mucinsArrowR-HSA-914008 (Reactome)
Core 6 mucinsR-HSA-1964501 (Reactome)
Core 7 mucinsArrowR-HSA-914017 (Reactome)
Core 8 mucinsArrowR-HSA-914006 (Reactome)
Disialyl T antigensArrowR-HSA-981809 (Reactome)
GALNT:COSMCmim-catalysisR-HSA-913675 (Reactome)
GCNT3mim-catalysisR-HSA-914018 (Reactome)
GCNTsmim-catalysisR-HSA-914012 (Reactome)
MucinsR-HSA-913675 (Reactome)
O-fuc-proteinsArrowR-HSA-5173192 (Reactome)
O-fuc-proteinsR-HSA-5173005 (Reactome)
POFUT2 substratesR-HSA-5173192 (Reactome)
POFUT2mim-catalysisR-HSA-5173192 (Reactome)
R-HSA-1964501 (Reactome) Beta-1,4-galactosyltransferase 5 (B4GALT5) mediates the transfer of galactose from UDP-galactose to Core 6 glycoproteins (Sato et al. 1998).
R-HSA-1964505 (Reactome) Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (C1GALT1) (Ju et al. 2002) mediates the transfer of galactose from UDP-galactose to Tn antigens to form Core 1 mucins. C1GALT1 is acitve when in complex with the molecular chaperone COSMC (C1GALT1C1) (Ju & Cummings 2002).
R-HSA-5173005 (Reactome) Sato et al. identified the human beta-1,3-glucosyltransferase-like protein (B3GALTL), localised on the ER membrane, which glucosylates O-fucosylated proteins (Sato et al. 2006). The resultant glc-beta-1,3-fuc disaccharide modification on TSR1 domain-containing proteins is thought assist in the secretion of many of these proteins from the ER lumen.
R-HSA-5173192 (Reactome) The O-fucosylation of proteins containing thrombospondin type 1 repeat (TSR1) domains is carried out by protein fucosyltransferase 2 (POFUT2). Only POFUT2 recognises the consensus sequence CSXS/TCG found in TSR1 domains and the fucosyl residue is attached to the hydroxyl group of conserved serine (S) or threonine (T) residues within the consensus sequence (Chen et al. 2012). The modification was first demonstrated on thrombospondin 1 (THBS1, TSP1), found in platelets and the ECM (Hofsteenge et al. 2001, Luo et al. 2006). In humans, there are more than 60 of these TSR1 domain-containing proteins. Only the proteins with similarity to experimentally confirmed ones are listed as candidates.
R-HSA-913675 (Reactome) The family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases (GalNAc-transferases, GALNTs) carry out the addition of N-acetylgalactosamine on serine or threonine residues of proteins, especially mucins (Wandall et al. 1997). This reaction takes place in the Golgi apparatus (Röttger et al. 1998). There are 20 known members of the GALNT family, 15 of which have been characterised and 5 candidate members which are thought to belong to this family based on sequence similarity. The molecular chaperone C1GALT1C1-specific chaperone (COSMC) is thought to be required for N-acetylgalactosaminyltransferase activity (Yu & Cummings 2002).
R-HSA-914005 (Reactome) An unknown N-acetylglucosaminyltransferase mediates the transfer of GlcNAc to Tn antigens via an alpha-1,3 linkage to create Core 5 mucins (Brockhausen et al. 2009).
R-HSA-914006 (Reactome) An unknown galactosyltransferase mediates the transfer of galactose is transferred to Tn antigens via an alpha-1,3 linkage to create Core 8 mucins (Brockhausen et al. 2009).
R-HSA-914008 (Reactome) An unknown N-acetylglucosaminyltransferase mediates the transfer of GlcNAc to Tn antigens via an beta-1,6 linkage to create Core 6 mucins (Brockhausen et al. 2009).
R-HSA-914010 (Reactome) The UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase family (B3GNTs) consists of 9 members in humans (Kolbinger et al, 1998; Shiraishi et al, 2001; Togayachi et al, 2001; Iwai et al, 2002; Huang et al, 2004; Ishida et al, 2005; Zheng et al, 2004). They catalyse the addition of N-acetylglucosamine to the T antigen to form the Core 3 glycoprotein (Togayachi et al, 2006). Thie reaction occurs in the Golgi.
R-HSA-914012 (Reactome) The human gene GCNT encodes beta-1,6-N-acetylglucosaminyltransferase which mediates core 2 O-glycan branching by the addition of N-acetylgalactosamine, an important step in mucin-type biosynthesis. There are 3 defined members in humans, 1, 3 and 4 (Bierhuizen and Fukuda, 1992; Yeh et al, 1999; Schwientek et al, 2000). Two members (6 and 7) may be part of the family based on sequence similarity.
R-HSA-914017 (Reactome) An unknown N-acetylgalactosaminyltransferase mediates the transfer of GalNAc is transferred to Tn antigens via an alpha-1,6 linkage to create Core 7 mucins (Brockhausen et al. 2009).
R-HSA-914018 (Reactome) The glycosyltransferase GCNT3 mediates core 2 and core 4 O-glycan branching (Yeh et al, 1999; Schwientek et al, 1999).
R-HSA-977071 (Reactome) Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1) transfers sialic acid (Neu5Ac) from the donor CMP-Neu5Ac to galactose-containing acceptor substrates such as the Tn antigen (Stamenkovic et al. 1990).
R-HSA-977228 (Reactome) Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1) transfers sialic acid (Neu5Ac) from the donor CMP-Neu5Ac to the T antigen (Stamenkovic et al. 1990).
R-HSA-981497 (Reactome) The human genes ST3GAL1-4 encode for sialyltransferases1-4 respectively (Shang et al. 1999, Kim et al. 1996, Kitagawa & Paulson 1993, Basu et al. 1993). They add silaic acid (Neu5Ac) onto the T antigen forming an alpha-3-sialyl O-glycan.
R-HSA-981809 (Reactome) The human genes ST6GALNAC3 and 4 encode GalNAc alpha-2,6-sialyltransferase III and IV respectively which can add sialic acid (Neu5Ac) to sialyl T antigen to produce a disialyl T antigen. ST6GALNAC4 is characterised (Harduin-Lepers et al. 2000) while ST6GALNAC3 is thought to perform a similar function based on sequence similarity.
R-HSA-981814 (Reactome) The huma gene ST6GALNAC2 encodes GalNAc alpha-2,6-sialyltransferase II which mediates the transfer of sialic acid (Neu5Ac) onto the T antigen (Samyn-Petit et al. 2000).
ST3GAL1-4mim-catalysisR-HSA-981497 (Reactome)
ST6GAL1mim-catalysisR-HSA-977071 (Reactome)
ST6GAL1mim-catalysisR-HSA-977228 (Reactome)
ST6GALNAC2mim-catalysisR-HSA-981814 (Reactome)
ST6GALNAC3/4mim-catalysisR-HSA-981809 (Reactome)
Sialyl Tn antigensArrowR-HSA-977071 (Reactome)
Sialyl-2,3 T antigensArrowR-HSA-981497 (Reactome)
Sialyl-2,3 T antigensR-HSA-981809 (Reactome)
Sialyl-2,6 T antigensArrowR-HSA-977228 (Reactome)
Sialyl-2,6 T antigensArrowR-HSA-981814 (Reactome)
Tn antigensArrowR-HSA-913675 (Reactome)
Tn antigensR-HSA-1964505 (Reactome)
Tn antigensR-HSA-914005 (Reactome)
Tn antigensR-HSA-914006 (Reactome)
Tn antigensR-HSA-914008 (Reactome)
Tn antigensR-HSA-914010 (Reactome)
Tn antigensR-HSA-914017 (Reactome)
Tn antigensR-HSA-977071 (Reactome)
UDP-GalNAcR-HSA-913675 (Reactome)
UDP-GalNAcR-HSA-914017 (Reactome)
UDP-GalR-HSA-1964501 (Reactome)
UDP-GalR-HSA-1964505 (Reactome)
UDP-GalR-HSA-914006 (Reactome)
UDP-GlcNAcR-HSA-914005 (Reactome)
UDP-GlcNAcR-HSA-914008 (Reactome)
UDP-GlcNAcR-HSA-914010 (Reactome)
UDP-GlcNAcR-HSA-914012 (Reactome)
UDP-GlcNAcR-HSA-914018 (Reactome)
UDPArrowR-HSA-1964501 (Reactome)
UDPArrowR-HSA-1964505 (Reactome)
UDPArrowR-HSA-913675 (Reactome)
UDPArrowR-HSA-914005 (Reactome)
UDPArrowR-HSA-914006 (Reactome)
UDPArrowR-HSA-914008 (Reactome)
UDPArrowR-HSA-914010 (Reactome)
UDPArrowR-HSA-914012 (Reactome)
UDPArrowR-HSA-914017 (Reactome)
UDPArrowR-HSA-914018 (Reactome)
extended Core 6 mucinsArrowR-HSA-1964501 (Reactome)
glc-fuc-proteinsArrowR-HSA-5173005 (Reactome)
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