RHO GTPases regulate CFTR trafficking (Homo sapiens)
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Description
Activated RHO GTPase RHOQ (TC10) regulates the trafficking of CFTR (cystic fibrosis transmembrane conductance regulator) by binding to GOPC (Golgi-associated and PDZ and coiled-coil motif-containing protein) also known as PIST, FIG or CAL. GOPC is a Golgi resident protein that binds several membrane proteins, thereby modulating their expression. In the absence of RHOQ, GOPC bound to CFTR directs CFTR for lysosomal degradation, while GTP-bound RHOQ directs GOPC:CFTR complex to the plasma membrane, thereby rescuing CFTR (Neudauer et al. 2001, Cheng et al. 2005).
Source:Reactome.
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Ontology Terms
Saving...Bibliography
- Neudauer CL, Joberty G, Macara IG.; ''PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10.''; PubMed Europe PMC Scholia
- Cheng J, Wang H, Guggino WB.; ''Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10.''; PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| CFTR | Protein | P13569 (Uniprot-TrEMBL)  | |
| GOPC | Protein | Q9HD26 (Uniprot-TrEMBL) | |
| GOPC:CFTR | Complex | R-HSA-5627082 (Reactome) | |
| GOPC:CFTR | Complex | R-HSA-5627276 (Reactome) | |
| GTP | Metabolite | CHEBI:15996 (ChEBI) | |
| RHOQ | Protein | P17081 (Uniprot-TrEMBL) | |
| RHOQ:GTP:GOPC:CFTR | Complex | R-HSA-5627078 (Reactome) | |
| RHOQ:GTP:GOPC:CFTR | Complex | R-HSA-5627084 (Reactome) | |
| RHOQ:GTP | Complex | R-HSA-5627068 (Reactome) |
Annotated Interactions
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| Source | Target | Type | Database reference | Comment |
|---|---|---|---|---|
| GOPC:CFTR | Arrow | R-HSA-5627275 (Reactome) | ||
| GOPC:CFTR | R-HSA-5627072 (Reactome) | |||
| GOPC:CFTR | R-HSA-5627275 (Reactome) | |||
| R-HSA-5627071 (Reactome) | While binding of GOPC (also known as CAL, PIST or FIG) to CFTR (cystic fibrosis transmembrane conductance regulator) promotes lysosomal degradation of CFTR, binding of active RHOQ to GOPC:CFTR complex redirects CFTR to the plasma membrane and prevents its degradation (Cheng et al. 2005). | |||
| R-HSA-5627072 (Reactome) | GTP-bound RHO GTPase RHOQ (TC10) binds GOPC (also known as PIST, CAL or FIG) dimer (Neudauer et al. 2001, Cheng et al. 2005) in complex with CFTR (cystic fibrosis transmembrane conductance regulator) on Golgi-associated vesicles (Cheng et al. 2005). | |||
| R-HSA-5627275 (Reactome) | Binding of GOPC (also known as CAL, PIST or FIG) to CFTR (cystic fibrosis transmembrane conductance regulator) promotes translocation of GOPC:CFTR complex to lysosomes, which is followed by lysosomal degradation of CFTR (Cheng et al. 2005). | |||
| RHOQ:GTP:GOPC:CFTR | Arrow | R-HSA-5627071 (Reactome) | ||
| RHOQ:GTP:GOPC:CFTR | Arrow | R-HSA-5627072 (Reactome) | ||
| RHOQ:GTP:GOPC:CFTR | R-HSA-5627071 (Reactome) | |||
| RHOQ:GTP | R-HSA-5627072 (Reactome) |
