Presynaptic depolarization and calcium channel opening (Homo sapiens)
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Description
The action potential travels down the axon and reaches the pre-synaptic terminal depolarizing the membrane in the pre-synaptic terminal. The depolarization causes the voltage-gated Ca2+ channels to open allowing the influx of Ca2+ that signals the release of neurotransmitter into the synaptic cleft.
View original pathway at:Reactome.
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Ontology Terms
Saving...Bibliography
- Diriong S, Lory P, Williams ME, Ellis SB, Harpold MM, Taviaux S.; ''Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits.''; PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| CACFD1 | Protein | Q9UGQ2 (Uniprot-TrEMBL)  | |
| CACFD1 dimer | Complex | R-HSA-5672066 (Reactome) | |
| CACNA1A | Protein | O00555 (Uniprot-TrEMBL) | |
| CACNA1B | Protein | Q00975 (Uniprot-TrEMBL) | |
| CACNA1E | Protein | Q15878 (Uniprot-TrEMBL) | |
| CACNA2D1(1-?) | Protein | Q9UIU0 (Uniprot-TrEMBL) | |
| CACNA2D2(19-1150) | Protein | Q9NY47 (Uniprot-TrEMBL) | |
| CACNA2D3 | Protein | Q8IZS8 (Uniprot-TrEMBL) | |
| CACNB1 | Protein | Q02641 (Uniprot-TrEMBL) | |
| CACNB2 | Protein | Q08289 (Uniprot-TrEMBL) | |
| CACNB3 | Protein | P54284 (Uniprot-TrEMBL) | |
| CACNB4 | Protein | O00305 (Uniprot-TrEMBL) | |
| CACNG2 | Protein | Q9Y698 (Uniprot-TrEMBL) | |
| CACNG4 | Protein | Q9UBN1 (Uniprot-TrEMBL) | |
| Ca2+ | Metabolite | CHEBI:29108 (ChEBI) | |
| K+ | Metabolite | CHEBI:29103 (ChEBI) | |
| Voltage Gated Ca2+ Channel | Complex | R-HSA-210378 (Reactome) |
Annotated Interactions
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| Source | Target | Type | Database reference | Comment |
|---|---|---|---|---|
| CACFD1 dimer | mim-catalysis | R-HSA-5263618 (Reactome) | ||
| Ca2+ | Arrow | R-HSA-210420 (Reactome) | ||
| Ca2+ | Arrow | R-HSA-5263618 (Reactome) | ||
| Ca2+ | R-HSA-210420 (Reactome) | |||
| Ca2+ | R-HSA-5263618 (Reactome) | |||
| K+ | TBar | R-HSA-210420 (Reactome) | ||
| R-HSA-210420 (Reactome) | Ca2+ influx from the extracellular space into the presynaptic neuron through the Voltage Gated Ca2+ Channels (VGCC), is dependant on the arrival of an action potential at the synaptic bulb. The vesicle fusion and subsequent release of glutamate into the synapse is triggered by this influx of Ca2+. The VGCCs involved here could be of the N, P/Q or R type. Hyperpolarization of the cell membrane due to KIR3 potassium channel activity inhibits this influx of Ca2+. | |||
| R-HSA-5263618 (Reactome) | In drosophila, the calcium channel flower (fwe) is a homomultimeric protein on the plasma membrane of cells that couples synaptic exocytosis with endocytosis, both processes being regulated by Ca2+. Influx of Ca2+, triggered by voltage-gated Ca2+ channels, is necessary for synaptic vesicle fusion with the plasma membrane. Drosophila fwe is able to mediate Ca2+ influx and thus regulate synaptic endocytosis. Fwe can form at least a dimer but also higher multimers (Yao et al. 2009). The function of human calcium channel flower homologue (CACFD1) is based on inference from functional drosophila fwe. | |||
| Voltage Gated Ca2+ Channel | mim-catalysis | R-HSA-210420 (Reactome) |
