Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)

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7, 283530664, 21, 56, 64, 6819, 51102960656514, 58, 632666231, 4311, 2526269393030236, 18, 44, 558, 335013344915404616, 325, 9, 12, 17, 24...365737625916, 3266654220, 4531225236211, 25endocytic vesicle membranecytosolnucleoplasmADCY1 GRIA1 p-T287-CAMK2G GRIN1 GABRR1 Mg2+ DLG4 GRIN2C GRIN2D CHRNA2 KCNJ5 p-T287-CAMK2D Gly GRIK3 GRIK4 ACTN2 NEFL L-GluGNAL GRIA1 ACTN2 DLG1 ADCY9 Ca2+GNG13 Edited GRIK2 (GluR6) GRIA4 CACNG3 GlyGNB4 ADCY1 GRIN2A p-T286-CAMK2A GRIK 3 homomerCl- GTP G-proteinbeta-gamma:PLC beta1/2/3CHRNA3 ADCY7 GNAT3 DLG4 ADPAP2A2-3 DLG4 AKAP9 CAMK4Kainatereceptor-glutamatecomplexDLG4 CHRNA3 CACNG3 GRIP2 GRIK1 GRIA4 KCNJ3 GRIK3 L-Glu ATPKCNJ12 p-T287-CAMK2D GRIN2A GNAT3 GDP Calmodulin:CaMK IVCa2+Mg2+ Cl- GABA B receptorG-proteinbeta-gamma and Kir3channel complexADCY4 CHRNA2 CHRNB4 p-T287-CAMK2D NEFL PLCB3 p-T287-CAMK2G ATPp-T286-CAMK2A PICK1K+PICK1Ca impermeable AMPAreceptor ligandcomplexp-T287-CAMK2B CHRNA1 O-acteylcholinebound to calciumpermeablepostsynapticnicotinicacetylcholinereceptorsPRKACA CHRNA3 Ca permeable AMPAreceptorsp-S360,S377,T570-RPS6KA2 GRIA1 ADCY3 Ca impermeable AMPAreceptorsNMDA receptorcomplexMYO6p-T287-CAMK2G Ca2+phospho-CaMKIV:CalmodulinCa2+G-protein alpha(i):GDPGNG10 GNAT3 AP2A1 CREB14xCa2+:CaMADCY7 DLG1 CAMK4 GRIN2D GRIA4 GNAI1 p-S221,S363,S380,T573-RPS6KA6 CALM1 GRIN2C ADCY6 p-T287-CAMK2D GRIN1 GRIN1 CHRND p-T287-CAMK2B (Gialpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP)GRIK3 Na+GDP ADCY3 L-GluGRIA2 NSFGRIA1 GTP p-S133-CREB1CHRNB2 GNG12 Ca impermeable AMPAreceptors (withphospho GluR2 S880)GNAI3 GNGT2 GNAI1 Gly CALM1 ADCY5 GNGT1 MYO6CALM1 CREB1GNAT3 ATPAdenylate cyclase(Mg2+ cofactor)Phospho(S363,S380,T573)-ribosomal S6 kinaseGRIA3 GABAB receptor:GABAAP2S1-1 ADCY8 DLG4 GABRA3 CHRNA4 GNG5 CaMKIIGRIA3 GRIA2 PPip-S363,S380,T573-RPS6KA1 GTP Na+GNG12 GABA CHRNA6 RasGTP-B raf compexHRAS CHRNA5 GNG11 CaMKIIMg2+ GRIN1 p-T286-CAMK2A CACNG8 Ca2+ MDM2 CHRNA7 L-Glu CHRNA4 Na+GNAI2 AP2A2-3 GNB3 KCNJ15 KCNJ2 PLCB3 GDP GNG2 DLG1CALM1 GNAI3 GABACHRNA7 kaiante ReceptorsGNAI3 Cl-GRIA1 ADCY3 p-T287-CAMK2G NEFL CHRNB2 ADCY4 DLG1ADPRPS6KA3 GRIA4 DLG4 GDP Ca/calmodulinactivated AdenylateCyclaseGRIA2 ACTN2 RASGRF2 p-T287-CAMK2D ADCY7 EPB41L1GABRB1 GNB2 ADCY6 PLCB1 ADPCa impermeable AMPAreceptorsCACNG8 CHRNE GNG4 GNG10 AKAP5p-T287-CAMK2B ACTN2 GRIK5 GRIA3 GABRB3 cAMPADCY4 CHRNA6 Ca2+ CHRNG PRKACG NMDA receptor-MgcomplexGRIN2A CALM1GRIK5 GRIP1/GRIP2CACNG4 AP2A1 ADPGNB3 p-S227,S369,S386,T573-RPS6KA3 ADCY3 CHRNB4 GRIN2D ADCY3 GRIP1/GRIP2AP2AL-Glu ADCY3 p-S221,S363,S380,T573-RPS6KA1 ADCY6 p-S369,S386,T573-RPS6KA3 GRIN2A ADPTARP-PSD95-Mdm2Cl- Na+GRIN2C AKAP9 G alpha-olf:GDPcomplexActivatedconventionalprotein kinase Cp-T286-CAMK2A GRIN1 p-T286-CAMK2A L-GluCALM1 ADP ADCY8 GTP RASGRF1 Ca2+GNB4 Ca2+p-T287-CAMK2B CHRNA4 p-T287-CAMK2B GABRA4 Ca2+p-T287-CAMK2B CHRNA9 AcCho p-T287-CAMK2B CHRNA6 p-CAMKK1CHRNA1 Na+p-S338-BRAF Pip-T287-CAMK2G GNG3 GNAT3 RASGRF2 p-T286-CAMK2A p-T287-CAMK2G KCNJ10 Edited KainatereceptorsCaMKIIATPL-GluGABRB2 ADCY9 RasGRF:Ca/calmodulinGNB1 PLCB1 ADPNEFL L-Glu GRIN2D CACNG4 Cl-Phosphatidylserine GRIA2 p-T287-CAMK2G GNB1 ADPGRIA3 GNGT1 DLG4 (Gialpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP)MAPK1GABBR1 Highly calciumpermeable nicotinicacetylcholinereceptorsCALM1 Ca2+ADPGNG5 Calmodulin:CaMK IVp-T287-CAMK2G GNG7 GNG12 PRKACB Mg2+ GABRR pentamer:GABACHRNB2 ADCY2 CHRNA5 Ca2+ CHRNA2 GTP p-S363,S380,T573-RPS6KA6 ADCY1 CHRNA2 Highly calciumpermeablepostsynaptic nicotinicacetylcholinereceptorsGNG2 CHRNB3 GNAI2 CAMK2 heteromerGRIK3 ADPRPS6KA2 ADCY8 TARP-PSD95-Mdm2GNB5 CHRNA4 CALM1 Kainatereceptor-glutamate-Gprotein complexGNG2 GRIK3 ATPGRIP2 AKAP9 GNG7 GRIK1 CHRNB4 AP2B1-1 Ca permeable AMPAreceptorsADCY8 Ca2+ATPGRIN2B PiGABRA6 GNGT2 ADCY9 CHRNA6 ADP Cl- ADCY5 GRIN2D ARHGEF9 GRIA4 BRAF CHRNB4 GRIP1 GRIA1 AP2M1-2 GNAL p-T286-CAMK2A GNG5 ADCY8 GNG8 AcCho GRIP2 AcCho (Gialpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP)CHRNA5 PLCB2 GNG8 GTP GRIA3 NMDA receptor ligandcomplexCAMK2heteromer:CALM:4xCa2+GNGT2 p-T286-CAMK2A GRIA2 CaMKIICa2+ GABRheteropentamers:GABAp-T287-CAMK2D GRIP1/GRIP2p-T287-CAMK2G O-Acetylcholinebound toAcetylcholinereceptorGNGT1 RPS6KA6 Cl- GRIN2B Mg2+p-T287-CAMK2B GRIK4 ADCY5 ADCY2 GNAI1 PRKCB L-Glu GTP p-T287-CAMK2G KCNJ6 ADCY5 GABBR2 GRIA1 CALM1 p-S12,S13-CAMK4 Edited GRIK 1 (GluR5) Edited GRIK2 (GluR6) GNAI1 Ca2+ RPS6KA1 L-Glu GABRQ ADCY1 GRIN2B GRIA4 GNG10 CACNG2 GNAI2 GNG4 GNB2 CHRNB2 AKAP5CHRNB4 GRIK2 ADCY2 CHRNA1 p-S218,S360,S377,T570-RPS6KA2 Ca2+ GABRR3 PiMg2+ PRKCA L-Glup-S360,S377,T570-RPS6KA2 CHRNA5 GNG11 CHRNA3 CHRND p-S363,S380,T573-RPS6KA6 GRIA1 ACTN2 CaMKIICHRNB3 GRIA3 L-GluCHRNB2 ATPGRIA4 AP2 complexCHRNA3 G-protein alpha (i):GTPGABA GABBR2 ADCY7 GNB3 CHRNA4 ADPp-T286-CAMK2A CHRNB3 p-T287-CAMK2D GNAI2 GRIK2 GRIA3 CHRNA4 p-T287-CAMK2G PLCB2 GABA GlyADCY8 RasGRFGNG7 ADCY2 GNB5 Mg2+ PDPK10-acteylcholinebound to calciumpermeable nictonicacteylcholinereceptor complexEdited KainateReceptor-glutamatecomplexGNAI3 p-S880-GRIA2 CHRNA9 GABRG2 p-T286-CAMK2A L-Glu EPB41L1CAMK4 CHRNE DLG4 PRKCG GNG8 DAG PICK1GRIN2A GABBR2 Ca2+ GNAI1 L-Glu p-T287-CAMK2D p-T287-CAMK2G Ca2+NCALD ADCY9 Cl- CHRNB3 Phospho(S363,S380,T573)- ribosomal S6 kinaseADPGTP CHRNA3 ATPKCNJ16 GNAL ATPGRIP1 G-protein alpha(i):GTP:AdenylatecyclaseADCY6 DLG3 CHRNA1 GRIP1 ADCY4 K+p-T287-CAMK2D GNG3 GRIA4 p-T286-CAMK2A ADCY5 GRIK3 homomerglutamate complexGRIA4 PiGABBR1 GABRA5 KCNJ9 GNAL GABA HRAS ATPADCY1 AKAP9 GABBR1 ADCY4 Ca impermeable AMPAreceptorsp-S369,S386,T573-RPS6KA3 ADCY2 CAMKK1AcChoGABAB receptorPiGNAI1 ADCY7 Ca impermeable AMPAreceptorsGNAI2 Edited GRIK 1 (GluR5) GNG4 GRIN2B DLG3 GRIN2C p-T185,Y187-MAPK1CHRNB4 GDP RRAS p-T287-CAMK2B GABRA2 CHRNB2 PRKACB-like proteinsPhospho(S221,S363,S380,T573)- ribosomal S6 kinaseGNAI3 GNAT3 GABRR2 GNB2 p-T287-CAMK2D p-T287-CAMK2B NEFL ADCY1 L-GluGRIA1 AKAP9 Ca2+p-T287-CAMK2B Ribosomal S6 kinaseGRIA3 GNG3 DLG4 CHRNG GNG13 RRAS ATPNMDA receptor ligandcomplexGly GRIN2B GNAI2 p-T287-CAMK2B p-T287-CAMK2D ADCY9 RASGRF1 p-S363,S380,T573-RPS6KA1 GNAI3 ADCY6 GNAL p-T286-CAMK2A GNB1 Na+p-S338-RAF1ATPCACNG2 L-Glu Na+Highly sodiumpermeable nicotinicacetylcholinereceptorsGABRG3 G alpha-olf:GTPGRIA3 GDP Ras:GTPp-T287-CAMK2D ADPActivated B-rafcomplexRas:GDPMDM2 Cl- GTP GRIN2C NCALD KCNJ4 Ca permeable AMPAreceptor ligandcomplexGABRA1 153861


Description

The neurotransmitter in the synaptic cleft released by the pre-synaptic neuron binds specific receptors located on the post-synaptic terminal. These receptors are either ion channels or G protein coupled receptors that function to transmit the signals from the post-synaptic membrane to the cell body. View original pathway at:Reactome.

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Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
118519view10:04, 28 May 2021EweitzOntology Term : 'neuron-to-neuron signaling pathway via the chemical synapse' added !
114633view16:09, 25 January 2021ReactomeTeamReactome version 75
113081view11:14, 2 November 2020ReactomeTeamReactome version 74
112315view15:23, 9 October 2020ReactomeTeamReactome version 73
101214view11:11, 1 November 2018ReactomeTeamreactome version 66
100752view20:36, 31 October 2018ReactomeTeamreactome version 65
100296view19:13, 31 October 2018ReactomeTeamreactome version 64
99842view15:57, 31 October 2018ReactomeTeamreactome version 63
99399view14:34, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
94502view09:18, 14 September 2017Mkutmonreactome version 61
86651view09:23, 11 July 2016ReactomeTeamreactome version 56
83166view10:15, 18 November 2015ReactomeTeamVersion54
81530view13:04, 21 August 2015ReactomeTeamVersion53
77001view08:29, 17 July 2014ReactomeTeamFixed remaining interactions
76706view12:07, 16 July 2014ReactomeTeamFixed remaining interactions
76032view10:09, 11 June 2014ReactomeTeamRe-fixing comment source
75741view11:22, 10 June 2014ReactomeTeamReactome 48 Update
75091view14:04, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74738view08:49, 30 April 2014ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP)ComplexR-HSA-170656 (Reactome)
(Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP)ComplexR-HSA-170659 (Reactome)
(Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP)ComplexR-HSA-170683 (Reactome)
0-acteylcholine

bound to calcium permeable nictonic acteylcholine

receptor complex		ComplexR-HSA-629600 (Reactome)
4xCa2+:CaMComplexR-HSA-74294 (Reactome)
ACTN2 ProteinP35609 (Uniprot-TrEMBL)
ADCY1 ProteinQ08828 (Uniprot-TrEMBL)
ADCY2 ProteinQ08462 (Uniprot-TrEMBL)
ADCY3 ProteinO60266 (Uniprot-TrEMBL)
ADCY4 ProteinQ8NFM4 (Uniprot-TrEMBL)
ADCY5 ProteinO95622 (Uniprot-TrEMBL)
ADCY6 ProteinO43306 (Uniprot-TrEMBL)
ADCY7 ProteinP51828 (Uniprot-TrEMBL)
ADCY8 ProteinP40145 (Uniprot-TrEMBL)
ADCY9 ProteinO60503 (Uniprot-TrEMBL)
ADP MetaboliteCHEBI:16761 (ChEBI)
ADPMetaboliteCHEBI:16761 (ChEBI)
AKAP5ProteinP24588 (Uniprot-TrEMBL)
AKAP9 ProteinQ99996 (Uniprot-TrEMBL)
AP2 complexComplexR-HSA-416629 (Reactome)
AP2A1 ProteinO95782 (Uniprot-TrEMBL)
AP2A2-3 ProteinO94973-3 (Uniprot-TrEMBL)
AP2AComplexR-HSA-416640 (Reactome)
AP2B1-1 ProteinP63010-1 (Uniprot-TrEMBL)
AP2M1-2 ProteinQ96CW1-2 (Uniprot-TrEMBL)
AP2S1-1 ProteinP53680-1 (Uniprot-TrEMBL)
ARHGEF9 ProteinO43307 (Uniprot-TrEMBL)
ATPMetaboliteCHEBI:15422 (ChEBI)
AcCho MetaboliteCHEBI:15355 (ChEBI)
AcChoMetaboliteCHEBI:15355 (ChEBI)
Activated

conventional

protein kinase C		ComplexR-HSA-139830 (Reactome)
Activated B-raf complexComplexR-HSA-1063697 (Reactome)
Adenylate cyclase (Mg2+ cofactor)ComplexR-HSA-170665 (Reactome)
BRAF ProteinP15056 (Uniprot-TrEMBL)
CACNG2 ProteinQ9Y698 (Uniprot-TrEMBL)
CACNG3 ProteinO60359 (Uniprot-TrEMBL)
CACNG4 ProteinQ9UBN1 (Uniprot-TrEMBL)
CACNG8 ProteinQ8WXS5 (Uniprot-TrEMBL)
CALM1 ProteinP62158 (Uniprot-TrEMBL)
CALM1ProteinP62158 (Uniprot-TrEMBL)
CAMK2 heteromer:CALM:4xCa2+ComplexR-HSA-444601 (Reactome)
CAMK2 heteromerComplexR-HSA-432792 (Reactome) CaMKII is composed of a homo or hetero dodecamer of four subunits apha, beta, delta and gamma. In a heteromultimer the ratio of alpha to beta may vary from 6;1, 3:1 or 1:1.
CAMK4 ProteinQ16566 (Uniprot-TrEMBL)
CAMK4ProteinQ16566 (Uniprot-TrEMBL)
CAMKK1ProteinQ8N5S9 (Uniprot-TrEMBL)
CHRNA1 ProteinP02708 (Uniprot-TrEMBL)
CHRNA2 ProteinQ15822 (Uniprot-TrEMBL)
CHRNA3 ProteinP32297 (Uniprot-TrEMBL)
CHRNA4 ProteinP43681 (Uniprot-TrEMBL)
CHRNA5 ProteinP30532 (Uniprot-TrEMBL)
CHRNA6 ProteinQ15825 (Uniprot-TrEMBL)
CHRNA7 ProteinP36544 (Uniprot-TrEMBL)
CHRNA9 ProteinQ9UGM1 (Uniprot-TrEMBL)
CHRNB2 ProteinP17787 (Uniprot-TrEMBL)
CHRNB3 ProteinQ05901 (Uniprot-TrEMBL)
CHRNB4 ProteinP30926 (Uniprot-TrEMBL)
CHRND ProteinQ07001 (Uniprot-TrEMBL)
CHRNE ProteinQ04844 (Uniprot-TrEMBL)
CHRNG ProteinP07510 (Uniprot-TrEMBL)
CREB1ProteinP16220 (Uniprot-TrEMBL)
Ca impermeable AMPA

receptor ligand

complex		ComplexR-HSA-420974 (Reactome)
Ca impermeable AMPA

receptors (with

phospho GluR2 S880)		ComplexR-HSA-421001 (Reactome)
Ca impermeable AMPA receptorsComplexR-HSA-399713 (Reactome)
Ca impermeable AMPA receptorsComplexR-HSA-416323 (Reactome)
Ca permeable AMPA

receptor ligand

complex		ComplexR-HSA-420976 (Reactome)
Ca permeable AMPA receptorsComplexR-HSA-399714 (Reactome)
Ca permeable AMPA receptorsComplexR-HSA-416325 (Reactome)
Ca/calmodulin

activated Adenylate

Cyclase		ComplexR-HSA-443461 (Reactome)
Ca2+ MetaboliteCHEBI:29108 (ChEBI)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
CaMKIIComplexR-HSA-417004 (Reactome) CaMKII is composed of a homo or hetero dodecamer of four subunits apha, beta, delta and gamma. In a heteromultimer the ratio of alpha to beta may vary from 6;1, 3:1 or 1:1.
CaMKIIComplexR-HSA-444796 (Reactome)
CaMKIIComplexR-HSA-445374 (Reactome)
Calmodulin:CaMK IVComplexR-HSA-111900 (Reactome)
Calmodulin:CaMK IVComplexR-HSA-112281 (Reactome)
Cl- MetaboliteCHEBI:17996 (ChEBI)
Cl-MetaboliteCHEBI:17996 (ChEBI)
DAG MetaboliteCHEBI:17815 (ChEBI)
DLG1 ProteinQ12959 (Uniprot-TrEMBL)
DLG1ProteinQ12959 (Uniprot-TrEMBL)
DLG3 ProteinQ92796 (Uniprot-TrEMBL)
DLG4 ProteinP78352 (Uniprot-TrEMBL)
EPB41L1ProteinQ9H4G0 (Uniprot-TrEMBL)
Edited GRIK 1 (GluR5) ProteinP39086 (Uniprot-TrEMBL) Glutamine at position 636 is replaced by arginine in an editing step which occurs posttranscriptionally.
Edited GRIK2 (GluR6) ProteinQ13002 (Uniprot-TrEMBL) GRIK2 is edited at the Q/R site at 621 where the glutamine is edited to arginine. GRIK2 is also edited at 571 (Y/C) where a tyrosine residue is changed to cysteine and 567 (I/V) where an isoleucine is changed to valine. All three sites are edited postranscriptionally. A fully edited GRIK2 at all three sites is totally impermeable to calcium ions.
Edited Kainate

Receptor-glutamate

complex		ComplexR-HSA-451304 (Reactome)
Edited Kainate receptorsComplexR-HSA-451279 (Reactome) Kainate receptors are formed by the assembly of four subunits. GluR5-7 (GRIK, glutamate receptor, ionotropic Kainate 1-3) form functional homomers whereas, KA1 and KA2 or GRIK4,5 form functional heteromers with GRIK1/2/3. Kainate receptor subunits bind Cl- ion in the anion binding site in the ligand binding domain. The dimer is stabilized by the presence of one Cl- ion which binds within the dimer interface.
G alpha-olf:GDP complexComplexR-HSA-170669 (Reactome)
G alpha-olf:GTPComplexR-HSA-170661 (Reactome)
G-protein

beta-gamma:PLC beta

1/2/3		ComplexR-HSA-398037 (Reactome)
G-protein alpha (i):GDPComplexR-HSA-392164 (Reactome)
G-protein alpha

(i):GTP:Adenylate

cyclase		ComplexR-HSA-396910 (Reactome)
G-protein alpha (i): GTPComplexR-HSA-392161 (Reactome)
GABA B receptor

G-protein beta-gamma and Kir3

channel complex		ComplexR-HSA-1013011 (Reactome)
GABA MetaboliteCHEBI:16865 (ChEBI)
GABAB receptor:GABAComplexR-HSA-420698 (Reactome)
GABAB receptorComplexR-HSA-420748 (Reactome)
GABAMetaboliteCHEBI:16865 (ChEBI)
GABBR1 ProteinQ9UBS5 (Uniprot-TrEMBL)
GABBR2 ProteinO75899 (Uniprot-TrEMBL)
GABR heteropentamers:GABAComplexR-HSA-975268 (Reactome)
GABRA1 ProteinP14867 (Uniprot-TrEMBL)
GABRA2 ProteinP47869 (Uniprot-TrEMBL)
GABRA3 ProteinP34903 (Uniprot-TrEMBL)
GABRA4 ProteinP48169 (Uniprot-TrEMBL)
GABRA5 ProteinP31644 (Uniprot-TrEMBL)
GABRA6 ProteinQ16445 (Uniprot-TrEMBL)
GABRB1 ProteinP18505 (Uniprot-TrEMBL)
GABRB2 ProteinP47870 (Uniprot-TrEMBL)
GABRB3 ProteinP28472 (Uniprot-TrEMBL)
GABRG2 ProteinP18507 (Uniprot-TrEMBL)
GABRG3 ProteinQ99928 (Uniprot-TrEMBL)
GABRQ ProteinQ9UN88 (Uniprot-TrEMBL)
GABRR pentamer:GABAComplexR-HSA-975448 (Reactome)
GABRR1 ProteinP24046 (Uniprot-TrEMBL)
GABRR2 ProteinP28476 (Uniprot-TrEMBL)
GABRR3 ProteinA8MPY1 (Uniprot-TrEMBL)
GDP MetaboliteCHEBI:17552 (ChEBI)
GNAI1 ProteinP63096 (Uniprot-TrEMBL)
GNAI2 ProteinP04899 (Uniprot-TrEMBL)
GNAI3 ProteinP08754 (Uniprot-TrEMBL)
GNAL ProteinP38405 (Uniprot-TrEMBL)
GNAT3 ProteinA8MTJ3 (Uniprot-TrEMBL)
GNB1 ProteinP62873 (Uniprot-TrEMBL)
GNB2 ProteinP62879 (Uniprot-TrEMBL)
GNB3 ProteinP16520 (Uniprot-TrEMBL)
GNB4 ProteinQ9HAV0 (Uniprot-TrEMBL)
GNB5 ProteinO14775 (Uniprot-TrEMBL)
GNG10 ProteinP50151 (Uniprot-TrEMBL)
GNG11 ProteinP61952 (Uniprot-TrEMBL)
GNG12 ProteinQ9UBI6 (Uniprot-TrEMBL)
GNG13 ProteinQ9P2W3 (Uniprot-TrEMBL)
GNG2 ProteinP59768 (Uniprot-TrEMBL)
GNG3 ProteinP63215 (Uniprot-TrEMBL)
GNG4 ProteinP50150 (Uniprot-TrEMBL)
GNG5 ProteinP63218 (Uniprot-TrEMBL)
GNG7 ProteinO60262 (Uniprot-TrEMBL)
GNG8 ProteinQ9UK08 (Uniprot-TrEMBL)
GNGT1 ProteinP63211 (Uniprot-TrEMBL)
GNGT2 ProteinO14610 (Uniprot-TrEMBL)
GRIA1 ProteinP42261 (Uniprot-TrEMBL)
GRIA2 ProteinP42262 (Uniprot-TrEMBL)
GRIA3 ProteinP42263 (Uniprot-TrEMBL)
GRIA4 ProteinP48058 (Uniprot-TrEMBL)
GRIK 3 homomerComplexR-HSA-450196 (Reactome)
GRIK1 ProteinP39086 (Uniprot-TrEMBL)
GRIK2 ProteinQ13002 (Uniprot-TrEMBL)
GRIK3 ProteinQ13003 (Uniprot-TrEMBL)
GRIK3 homomer glutamate complexComplexR-HSA-500705 (Reactome)
GRIK4 ProteinQ16099 (Uniprot-TrEMBL)
GRIK5 ProteinQ16478 (Uniprot-TrEMBL)
GRIN1 ProteinQ05586 (Uniprot-TrEMBL)
GRIN2A ProteinQ12879 (Uniprot-TrEMBL)
GRIN2B ProteinQ13224 (Uniprot-TrEMBL)
GRIN2C ProteinQ14957 (Uniprot-TrEMBL)
GRIN2D ProteinO15399 (Uniprot-TrEMBL)
GRIP1 ProteinQ9Y3R0 (Uniprot-TrEMBL)
GRIP1/GRIP2ComplexR-HSA-416631 (Reactome)
GRIP1/GRIP2ComplexR-HSA-416636 (Reactome)
GRIP2 ProteinQ9C0E4 (Uniprot-TrEMBL)
GTP MetaboliteCHEBI:15996 (ChEBI)
Gly MetaboliteCHEBI:15428 (ChEBI)
GlyMetaboliteCHEBI:15428 (ChEBI)
HRAS ProteinP01112 (Uniprot-TrEMBL)
Highly calcium

permeable postsynaptic nicotinic acetylcholine

receptors		ComplexR-HSA-629581 (Reactome)
Highly calcium

permeable nicotinic acetylcholine

receptors		ComplexR-HSA-629586 (Reactome)
Highly sodium

permeable nicotinic acetylcholine

receptors		ComplexR-HSA-629576 (Reactome)
K+MetaboliteCHEBI:29103 (ChEBI)
KCNJ10 ProteinP78508 (Uniprot-TrEMBL)
KCNJ12 ProteinQ14500 (Uniprot-TrEMBL)
KCNJ15 ProteinQ99712 (Uniprot-TrEMBL)
KCNJ16 ProteinQ9NPI9 (Uniprot-TrEMBL)
KCNJ2 ProteinP63252 (Uniprot-TrEMBL)
KCNJ3 ProteinP48549 (Uniprot-TrEMBL)
KCNJ4 ProteinP48050 (Uniprot-TrEMBL)
KCNJ5 ProteinP48544 (Uniprot-TrEMBL)
KCNJ6 ProteinP48051 (Uniprot-TrEMBL)
KCNJ9 ProteinQ92806 (Uniprot-TrEMBL)
Kainate

receptor-glutamate

complex		ComplexR-HSA-451281 (Reactome)
Kainate receptor-glutamate-Gprotein complexComplexR-HSA-500703 (Reactome)
L-Glu MetaboliteCHEBI:16015 (ChEBI)
L-GluMetaboliteCHEBI:16015 (ChEBI)
MAPK1ProteinP28482 (Uniprot-TrEMBL)
MDM2 ProteinQ00987 (Uniprot-TrEMBL)
MYO6ProteinQ9UM54 (Uniprot-TrEMBL)
Mg2+ MetaboliteCHEBI:18420 (ChEBI)
Mg2+MetaboliteCHEBI:18420 (ChEBI)
NCALD ProteinP61601 (Uniprot-TrEMBL)
NEFL ProteinP07196 (Uniprot-TrEMBL)
NMDA receptor complexComplexR-HSA-419566 (Reactome) NMDAR complex consists of two NR1 subunits and two NR2 subunits. Each subunit has extensive C terminal tail that is modified by series of protein kinases and protein phosphatases. The NR1 subunits binds co-agonist glycine while the NR2 subunit binds glutamate. Hence the activation of NR1/NR2 containing NMDA receptor complexes are activated upon depolarization of the membrane and binding of both glycine and glutamate. The dual requirement of membrane depolarization and agonist binding facilitate coincidence detection by NMDA receptors that ensures activation of both pre-synaptic and post-synaptic cell. NR1/NR2 containing NMDA receptors are highly Ca2+ permeable and subjected to a voltage dependent Mg2+ block.
NMDA receptor ligand complexComplexR-HSA-432783 (Reactome)
NMDA receptor-Mg complexComplexR-HSA-438039 (Reactome)
NSFProteinP46459 (Uniprot-TrEMBL)
Na+MetaboliteCHEBI:29101 (ChEBI)
O-Acetylcholine

bound to Acetylcholine

receptor		ComplexR-HSA-629590 (Reactome)
O-acteylcholine

bound to calcium permeable postsynaptic nicotinic acetylcholine

receptors		ComplexR-HSA-629592 (Reactome)
PDPK1ProteinO15530 (Uniprot-TrEMBL)
PICK1ProteinQ9NRD5 (Uniprot-TrEMBL)
PLCB1 ProteinQ9NQ66 (Uniprot-TrEMBL)
PLCB2 ProteinQ00722 (Uniprot-TrEMBL)
PLCB3 ProteinQ01970 (Uniprot-TrEMBL)
PPiMetaboliteCHEBI:29888 (ChEBI)
PRKACA ProteinP17612 (Uniprot-TrEMBL)
PRKACB ProteinP22694 (Uniprot-TrEMBL)
PRKACB-like proteinsComplexR-HSA-4127466 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
PRKACG ProteinP22612 (Uniprot-TrEMBL)
PRKCA ProteinP17252 (Uniprot-TrEMBL)
PRKCB ProteinP05771 (Uniprot-TrEMBL)
PRKCG ProteinP05129 (Uniprot-TrEMBL)
Phosphatidylserine MetaboliteCHEBI:18303 (ChEBI)
Phospho(S221,S363,S380,T573)- ribosomal S6 kinaseComplexR-HSA-444291 (Reactome)
Phospho(S363,S380,T573)- ribosomal S6 kinaseComplexR-HSA-444261 (Reactome)
Phospho(S363,S380,T573)-ribosomal S6 kinaseComplexR-HSA-445403 (Reactome)
PiMetaboliteCHEBI:18367 (ChEBI)
RASGRF1 ProteinQ13972 (Uniprot-TrEMBL)
RASGRF2 ProteinO14827 (Uniprot-TrEMBL)
RPS6KA1 ProteinQ15418 (Uniprot-TrEMBL)
RPS6KA2 ProteinQ15349 (Uniprot-TrEMBL)
RPS6KA3 ProteinP51812 (Uniprot-TrEMBL)
RPS6KA6 ProteinQ9UK32 (Uniprot-TrEMBL)
RRAS ProteinP10301 (Uniprot-TrEMBL)
Ras:GDPComplexR-HSA-206896 (Reactome)
Ras:GTPComplexR-HSA-206946 (Reactome)
RasGRF:Ca/calmodulinComplexR-HSA-442735 (Reactome)
RasGRFComplexR-HSA-442734 (Reactome)
RasGTP-B raf compexComplexR-HSA-1063687 (Reactome)
Ribosomal S6 kinaseComplexR-HSA-444247 (Reactome)
TARP-PSD95-Mdm2ComplexR-HSA-416329 (Reactome)
TARP-PSD95-Mdm2ComplexR-HSA-416851 (Reactome)
cAMPMetaboliteCHEBI:17489 (ChEBI)
kaiante ReceptorsComplexR-HSA-450885 (Reactome) Kainate receptors are formed by the assembly of four subunits. GluR5-7 (GRIK, glutamate receptor, ionotropic Kainate 1-3) form functional homomers whereas, KA1 and KA2 or GRIK4,5 form functional heteromers with GRIK1/2/3. Kainate receptor subunits bind Cl- ion in the anion binding site in the ligand binding domain. The dimer is stabilized by the presence of one Cl- ion which binds within the dimer interface.
p-CAMKK1ProteinQ8N5S9 (Uniprot-TrEMBL)
p-S12,S13-CAMK4 ProteinQ16566 (Uniprot-TrEMBL)
p-S133-CREB1ProteinP16220 (Uniprot-TrEMBL)
p-S218,S360,S377,T570-RPS6KA2 ProteinQ15349 (Uniprot-TrEMBL)
p-S221,S363,S380,T573-RPS6KA1 ProteinQ15418 (Uniprot-TrEMBL)
p-S221,S363,S380,T573-RPS6KA6 ProteinQ9UK32 (Uniprot-TrEMBL)
p-S227,S369,S386,T573-RPS6KA3 ProteinP51812 (Uniprot-TrEMBL)
p-S338-BRAF ProteinP15056 (Uniprot-TrEMBL)
p-S338-RAF1ProteinP04049 (Uniprot-TrEMBL)
p-S360,S377,T570-RPS6KA2 ProteinQ15349 (Uniprot-TrEMBL)
p-S363,S380,T573-RPS6KA1 ProteinQ15418 (Uniprot-TrEMBL)
p-S363,S380,T573-RPS6KA6 ProteinQ9UK32 (Uniprot-TrEMBL)
p-S369,S386,T573-RPS6KA3 ProteinP51812 (Uniprot-TrEMBL)
p-S880-GRIA2 ProteinP42262 (Uniprot-TrEMBL)
p-T185,Y187-MAPK1ProteinP28482 (Uniprot-TrEMBL)
p-T286-CAMK2A ProteinQ9UQM7 (Uniprot-TrEMBL)
p-T287-CAMK2B ProteinQ13554 (Uniprot-TrEMBL)
p-T287-CAMK2D ProteinQ13557 (Uniprot-TrEMBL)
p-T287-CAMK2G ProteinQ13555 (Uniprot-TrEMBL)
phospho-CaMK IV:CalmodulinComplexR-HSA-111904 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP)ArrowR-HSA-170686 (Reactome)
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP)R-HSA-170674 (Reactome)
(Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP)ArrowR-HSA-170666 (Reactome)
(Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP)ArrowR-HSA-170671 (Reactome)
(Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP)R-HSA-170666 (Reactome)
(Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP)R-HSA-170686 (Reactome)
(Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP)mim-catalysisR-HSA-170666 (Reactome)
(Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP)mim-catalysisR-HSA-170686 (Reactome)
0-acteylcholine

bound to calcium permeable nictonic acteylcholine

receptor complex		ArrowR-HSA-629599 (Reactome)
4xCa2+:CaMR-HSA-111913 (Reactome)
4xCa2+:CaMR-HSA-442725 (Reactome)
ADPArrowR-HSA-111915 (Reactome)
ADPArrowR-HSA-416320 (Reactome)
ADPArrowR-HSA-416639 (Reactome)
ADPArrowR-HSA-416985 (Reactome)
ADPArrowR-HSA-421007 (Reactome)
ADPArrowR-HSA-442724 (Reactome)
ADPArrowR-HSA-442726 (Reactome)
ADPArrowR-HSA-442737 (Reactome)
ADPArrowR-HSA-442739 (Reactome)
ADPArrowR-HSA-442749 (Reactome)
ADPArrowR-HSA-443474 (Reactome)
ADPArrowR-HSA-443475 (Reactome)
ADPArrowR-HSA-443480 (Reactome)
ADPArrowR-HSA-444253 (Reactome)
AKAP5ArrowR-HSA-416320 (Reactome)
AKAP5R-HSA-416320 (Reactome)
AP2 complexArrowR-HSA-416639 (Reactome)
AP2 complexR-HSA-416639 (Reactome)
AP2AArrowR-HSA-421007 (Reactome)
AP2AR-HSA-421007 (Reactome)
ATPR-HSA-111915 (Reactome)
ATPR-HSA-416320 (Reactome)
ATPR-HSA-416639 (Reactome)
ATPR-HSA-416985 (Reactome)
ATPR-HSA-421007 (Reactome)
ATPR-HSA-442715 (Reactome)
ATPR-HSA-442724 (Reactome)
ATPR-HSA-442726 (Reactome)
ATPR-HSA-442737 (Reactome)
ATPR-HSA-442739 (Reactome)
ATPR-HSA-442749 (Reactome)
ATPR-HSA-443474 (Reactome)
ATPR-HSA-443475 (Reactome)
ATPR-HSA-443480 (Reactome)
ATPR-HSA-444253 (Reactome)
AcChoR-HSA-629588 (Reactome)
AcChoR-HSA-629596 (Reactome)
AcChoR-HSA-629599 (Reactome)
Activated

conventional

protein kinase C		mim-catalysisR-HSA-416639 (Reactome)
Activated

conventional

protein kinase C		mim-catalysisR-HSA-421007 (Reactome)
Activated B-raf complexArrowR-HSA-442726 (Reactome)
Adenylate cyclase (Mg2+ cofactor)ArrowR-HSA-170674 (Reactome)
Adenylate cyclase (Mg2+ cofactor)R-HSA-392206 (Reactome)
CALM1R-HSA-442760 (Reactome)
CAMK2 heteromer:CALM:4xCa2+ArrowR-HSA-442725 (Reactome)
CAMK2 heteromerR-HSA-442725 (Reactome)
CAMK2 heteromerR-HSA-445367 (Reactome)
CAMK4R-HSA-111913 (Reactome)
CAMKK1R-HSA-442749 (Reactome)
CAMKK1mim-catalysisR-HSA-442749 (Reactome)
CREB1R-HSA-442724 (Reactome)
CREB1R-HSA-443474 (Reactome)
CREB1R-HSA-443475 (Reactome)
CREB1R-HSA-443480 (Reactome)
Ca impermeable AMPA

receptor ligand

complex		ArrowR-HSA-420975 (Reactome)
Ca impermeable AMPA

receptor ligand

complex		R-HSA-399711 (Reactome)
Ca impermeable AMPA

receptors (with

phospho GluR2 S880)		R-HSA-421007 (Reactome)
Ca impermeable AMPA receptorsArrowR-HSA-399711 (Reactome)
Ca impermeable AMPA receptorsArrowR-HSA-416639 (Reactome)
Ca impermeable AMPA receptorsArrowR-HSA-416985 (Reactome)
Ca impermeable AMPA receptorsArrowR-HSA-421007 (Reactome)
Ca impermeable AMPA receptorsArrowR-HSA-438037 (Reactome)
Ca impermeable AMPA receptorsR-HSA-416639 (Reactome)
Ca impermeable AMPA receptorsR-HSA-416985 (Reactome)
Ca impermeable AMPA receptorsR-HSA-420975 (Reactome)
Ca impermeable AMPA receptorsR-HSA-438037 (Reactome)
Ca impermeable AMPA receptorsmim-catalysisR-HSA-399711 (Reactome)
Ca impermeable AMPA receptorsmim-catalysisR-HSA-432162 (Reactome)
Ca impermeable AMPA receptorsmim-catalysisR-HSA-438037 (Reactome)
Ca permeable AMPA

receptor ligand

complex		ArrowR-HSA-420977 (Reactome)
Ca permeable AMPA

receptor ligand

complex		R-HSA-399712 (Reactome)
Ca permeable AMPA

receptor ligand

complex		R-HSA-420980 (Reactome)
Ca permeable AMPA receptorsArrowR-HSA-399712 (Reactome)
Ca permeable AMPA receptorsArrowR-HSA-416320 (Reactome)
Ca permeable AMPA receptorsArrowR-HSA-420980 (Reactome)
Ca permeable AMPA receptorsR-HSA-416320 (Reactome)
Ca permeable AMPA receptorsR-HSA-420977 (Reactome)
Ca permeable AMPA receptorsmim-catalysisR-HSA-399712 (Reactome)
Ca permeable AMPA receptorsmim-catalysisR-HSA-420980 (Reactome)
Ca/calmodulin

activated Adenylate

Cyclase		mim-catalysisR-HSA-442715 (Reactome)
Ca2+ArrowR-HSA-399712 (Reactome)
Ca2+ArrowR-HSA-432164 (Reactome)
Ca2+ArrowR-HSA-442715 (Reactome)
Ca2+ArrowR-HSA-451311 (Reactome)
Ca2+ArrowR-HSA-622326 (Reactome)
Ca2+ArrowR-HSA-629595 (Reactome)
Ca2+R-HSA-399712 (Reactome)
Ca2+R-HSA-432164 (Reactome)
Ca2+R-HSA-442715 (Reactome)
Ca2+R-HSA-442760 (Reactome)
Ca2+R-HSA-451311 (Reactome)
Ca2+R-HSA-622326 (Reactome)
Ca2+R-HSA-629595 (Reactome)
CaMKIIArrowR-HSA-444792 (Reactome)
CaMKIIArrowR-HSA-445367 (Reactome)
CaMKIIR-HSA-444792 (Reactome)
CaMKIImim-catalysisR-HSA-416320 (Reactome)
CaMKIImim-catalysisR-HSA-442725 (Reactome)
CaMKIImim-catalysisR-HSA-442726 (Reactome)
CaMKIImim-catalysisR-HSA-443475 (Reactome)
Calmodulin:CaMK IVArrowR-HSA-111913 (Reactome)
Calmodulin:CaMK IVArrowR-HSA-112282 (Reactome)
Calmodulin:CaMK IVR-HSA-111915 (Reactome)
Calmodulin:CaMK IVR-HSA-112282 (Reactome)
Calmodulin:CaMK IVmim-catalysisR-HSA-111915 (Reactome)
Calmodulin:CaMK IVmim-catalysisR-HSA-443480 (Reactome)
Cl-ArrowR-HSA-975340 (Reactome)
Cl-ArrowR-HSA-975449 (Reactome)
Cl-R-HSA-975340 (Reactome)
Cl-R-HSA-975449 (Reactome)
DLG1ArrowR-HSA-416320 (Reactome)
DLG1R-HSA-416320 (Reactome)
EPB41L1ArrowR-HSA-416320 (Reactome)
EPB41L1R-HSA-416320 (Reactome)
Edited Kainate

Receptor-glutamate

complex		ArrowR-HSA-451309 (Reactome)
Edited Kainate

Receptor-glutamate

complex		R-HSA-451310 (Reactome)
Edited Kainate receptorsArrowR-HSA-451310 (Reactome)
Edited Kainate receptorsR-HSA-451309 (Reactome)
Edited Kainate receptorsmim-catalysisR-HSA-451310 (Reactome)
G alpha-olf:GDP complexArrowR-HSA-170674 (Reactome)
G alpha-olf:GTPR-HSA-170671 (Reactome)
G-protein

beta-gamma:PLC beta

1/2/3		R-HSA-500717 (Reactome)
G-protein alpha (i):GDPArrowR-HSA-170674 (Reactome)
G-protein alpha

(i):GTP:Adenylate

cyclase		ArrowR-HSA-392206 (Reactome)
G-protein alpha

(i):GTP:Adenylate

cyclase		R-HSA-170671 (Reactome)
G-protein alpha (i): GTPR-HSA-392206 (Reactome)
GABA B receptor

G-protein beta-gamma and Kir3

channel complex		mim-catalysisR-HSA-1013020 (Reactome)
GABAB receptor:GABAArrowR-HSA-420688 (Reactome)
GABAB receptorR-HSA-420688 (Reactome)
GABAR-HSA-420688 (Reactome)
GABR heteropentamers:GABAmim-catalysisR-HSA-975340 (Reactome)
GABRR pentamer:GABAmim-catalysisR-HSA-975449 (Reactome)
GRIK 3 homomerR-HSA-500708 (Reactome)
GRIK3 homomer glutamate complexArrowR-HSA-500708 (Reactome)
GRIK3 homomer glutamate complexR-HSA-500717 (Reactome)
GRIK3 homomer glutamate complexmim-catalysisR-HSA-500717 (Reactome)
GRIP1/GRIP2ArrowR-HSA-416639 (Reactome)
GRIP1/GRIP2ArrowR-HSA-416985 (Reactome)
GRIP1/GRIP2ArrowR-HSA-421007 (Reactome)
GRIP1/GRIP2R-HSA-416639 (Reactome)
GRIP1/GRIP2R-HSA-416985 (Reactome)
GRIP1/GRIP2R-HSA-421007 (Reactome)
GlyArrowR-HSA-432164 (Reactome)
GlyR-HSA-432164 (Reactome)
GlyR-HSA-432172 (Reactome)
Highly calcium

permeable postsynaptic nicotinic acetylcholine

receptors		ArrowR-HSA-629595 (Reactome)
Highly calcium

permeable postsynaptic nicotinic acetylcholine

receptors		R-HSA-629595 (Reactome)
Highly calcium

permeable postsynaptic nicotinic acetylcholine

receptors		R-HSA-629596 (Reactome)
Highly calcium

permeable postsynaptic nicotinic acetylcholine

receptors		mim-catalysisR-HSA-629595 (Reactome)
Highly calcium

permeable nicotinic acetylcholine

receptors		ArrowR-HSA-622326 (Reactome)
Highly calcium

permeable nicotinic acetylcholine

receptors		R-HSA-622326 (Reactome)
Highly calcium

permeable nicotinic acetylcholine

receptors		R-HSA-629599 (Reactome)
Highly calcium

permeable nicotinic acetylcholine

receptors		mim-catalysisR-HSA-622326 (Reactome)
Highly sodium

permeable nicotinic acetylcholine

receptors		ArrowR-HSA-622325 (Reactome)
Highly sodium

permeable nicotinic acetylcholine

receptors		R-HSA-622325 (Reactome)
Highly sodium

permeable nicotinic acetylcholine

receptors		R-HSA-629588 (Reactome)
Highly sodium

permeable nicotinic acetylcholine

receptors		mim-catalysisR-HSA-622325 (Reactome)
K+ArrowR-HSA-1013020 (Reactome)
K+R-HSA-1013020 (Reactome)
Kainate

receptor-glutamate

complex		ArrowR-HSA-451283 (Reactome)
Kainate

receptor-glutamate

complex		R-HSA-451311 (Reactome)
Kainate receptor-glutamate-Gprotein complexArrowR-HSA-500717 (Reactome)
L-GluArrowR-HSA-399711 (Reactome)
L-GluArrowR-HSA-399712 (Reactome)
L-GluArrowR-HSA-420980 (Reactome)
L-GluArrowR-HSA-432164 (Reactome)
L-GluArrowR-HSA-451310 (Reactome)
L-GluArrowR-HSA-451311 (Reactome)
L-GluR-HSA-420975 (Reactome)
L-GluR-HSA-420977 (Reactome)
L-GluR-HSA-432164 (Reactome)
L-GluR-HSA-432172 (Reactome)
L-GluR-HSA-451283 (Reactome)
L-GluR-HSA-451309 (Reactome)
L-GluR-HSA-500708 (Reactome)
MAPK1R-HSA-442737 (Reactome)
MYO6ArrowR-HSA-416320 (Reactome)
MYO6R-HSA-416320 (Reactome)
Mg2+ArrowR-HSA-432162 (Reactome)
NMDA receptor complexArrowR-HSA-432162 (Reactome)
NMDA receptor complexArrowR-HSA-432164 (Reactome)
NMDA receptor complexR-HSA-432172 (Reactome)
NMDA receptor ligand complexArrowR-HSA-432172 (Reactome)
NMDA receptor ligand complexR-HSA-432164 (Reactome)
NMDA receptor ligand complexR-HSA-442760 (Reactome)
NMDA receptor ligand complexmim-catalysisR-HSA-432164 (Reactome)
NMDA receptor ligand complexmim-catalysisR-HSA-442760 (Reactome)
NMDA receptor ligand complexmim-catalysisR-HSA-445367 (Reactome)
NMDA receptor-Mg complexR-HSA-432162 (Reactome)
NSFmim-catalysisR-HSA-416985 (Reactome)
Na+ArrowR-HSA-399711 (Reactome)
Na+ArrowR-HSA-420980 (Reactome)
Na+ArrowR-HSA-432162 (Reactome)
Na+ArrowR-HSA-438037 (Reactome)
Na+ArrowR-HSA-451310 (Reactome)
Na+ArrowR-HSA-622325 (Reactome)
Na+R-HSA-399711 (Reactome)
Na+R-HSA-420980 (Reactome)
Na+R-HSA-438037 (Reactome)
Na+R-HSA-451310 (Reactome)
Na+R-HSA-622325 (Reactome)
O-Acetylcholine

bound to Acetylcholine

receptor		ArrowR-HSA-629588 (Reactome)
O-acteylcholine

bound to calcium permeable postsynaptic nicotinic acetylcholine

receptors		ArrowR-HSA-629596 (Reactome)
PDPK1mim-catalysisR-HSA-442739 (Reactome)
PICK1ArrowR-HSA-416639 (Reactome)
PICK1ArrowR-HSA-416985 (Reactome)
PICK1ArrowR-HSA-421007 (Reactome)
PICK1R-HSA-416639 (Reactome)
PICK1R-HSA-416985 (Reactome)
PICK1R-HSA-421007 (Reactome)
PPiArrowR-HSA-442715 (Reactome)
PRKACB-like proteinsmim-catalysisR-HSA-443474 (Reactome)
Phospho(S221,S363,S380,T573)- ribosomal S6 kinaseArrowR-HSA-442739 (Reactome)
Phospho(S221,S363,S380,T573)- ribosomal S6 kinasemim-catalysisR-HSA-442724 (Reactome)
Phospho(S363,S380,T573)- ribosomal S6 kinaseR-HSA-442739 (Reactome)
Phospho(S363,S380,T573)-ribosomal S6 kinaseArrowR-HSA-444253 (Reactome)
PiArrowR-HSA-170666 (Reactome)
PiArrowR-HSA-170686 (Reactome)
PiArrowR-HSA-416320 (Reactome)
PiArrowR-HSA-416639 (Reactome)
PiArrowR-HSA-421007 (Reactome)
PiR-HSA-416985 (Reactome)
R-HSA-1013020 (Reactome) Binding of G beta gamma activates the GIRK/Kir3 channels that allow the efflux of K+ out of the cell resulting in a hyperpolarized membrane potential. This negative membrane potential prevents the activation of voltage dependent Ca2+ channels.
R-HSA-111913 (Reactome) CaMKIV becomes fully activated after a three-step mechanism: Upon a transient increase in intracellular calcium, calcium-bound calmodulin (Ca2+/CaM) binds to its autoregulatory domain, which relieves intersteric inhibition. An activating protein kinase, calcium/calmodulin-dependent protein kinase kinase (CaMKK), binds to the Ca2+/CaM:CaMKIV complex and phosphorylates CaMKIV on a threonine residue in the activation loop. After full activation by the three-step mechanism mentioned above, the activity of CaMKIV becomes autonomous and no longer requires bound Ca2+/CaM. This activity is required for CaMKIV-mediated transcriptional regulation. The CaMKIV-associated PP2A then dephosphorylates CaMKIV, thereby terminating autonomous activity and CaMKIV-mediated gene transcription.
R-HSA-111915 (Reactome) Autophosphorylation of the N-terminus Ser12-Ser13 is required for full activation after Ca2+/calmodulin binding and phosphorylation of the Ca2+/calmodulin-bound enzyme on Thr200 by a Ca2+/calmodulin-dependent protein kinase kinase.
R-HSA-112282 (Reactome) The calmodulin:CaMK IV complex enters the nucleus.
R-HSA-170666 (Reactome) G proteins can deactivate themselves via their intrinsic GTPase activity, which hydrolyzes GTP to GDP. Effectors such as adenylate cyclase can increase the G protein GTPase rate, acting like GTPase-activating proteins (GAPs).
R-HSA-170671 (Reactome) The chronic activation of mu-opioid receptors, which, when coupled to pertussis toxin-sensitive Galpha-i/o proteins, inhibit adenylyl cyclase (AC).
R-HSA-170674 (Reactome) Once the intrinsic GTPase hydrolyzes GTP to GDP, Galpha-i dissociates from adenylate cyclase, allowing it to re-associate with G-beta-gamma and starting a new cycle.
R-HSA-170686 (Reactome) G proteins can deactivate themselves via their intrinsic GTPase activity, which hydrolyzes GTP to GDP. Effectors such as adenylate cyclase can increase the G protein GTPase rate, acting like GTPase-activating proteins (GAPs).
R-HSA-392206 (Reactome) G-proteins in the Gi class inhibit adenylate cyclase activity, decreasing the production of cAMP from ATP, which has many consequences but classically results in decreased activity of Protein Kinase A (PKA). cAMP also activates the cyclic nucleotide-gated ion channels, a process that is particularly important in olfactory cells.
R-HSA-399711 (Reactome) Each AMPA receptor subunit binds one glutamate molecule in the ligand binding site in the N terminus. Each receptor is capable of binding four glutamate molecules however, channel opens when two sites are occupied by the ligand and the current increases with increased ligand binding. Ca impermeable AMPA receptors containing GluR2 subunit conduct Na currents upon activation by either glutamate binding or agonist, AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) binding. The Na currents mainly lead to depolarization of the membrane leading to activation of voltage gated channels such as NMDA receptors that require both agonist binding and depolarization for their activation.
R-HSA-399712 (Reactome) Each AMPA receptor subunit binds one glutamate molecule in the ligand binding site in the N terminus. Each receptor is capable of binding four glutamate molecule, however, channel opens when two sites are occupied by the ligand and the current increases with increased ligand binding. Ca permeable AMPA receptors containing homomers of GluR1 or heteromers containing GluR1, GluR3 and GluR4 conduct Ca upon glutamate or agonist namely AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) binding. Calcium permeable AMPA receptors conduct Ca and other cations such as Na. The inonic flux leads to Ca or Na currents that leads to either increase in the intracellular Ca concentration leading to further Ca-dependent signaling or increase in depolarization that opens voltage gated channels such as NMDA receptors that require both membrane depolarization and glutamate binding for activation.
R-HSA-416320 (Reactome) GluR1-containing AMPA receptors are delivered to the synapses in an activity dependent manner. GluR1 trafficking is controlled by protein- protein interactions with 4.1N/G protein, SAP97 and by intricate regulation of phosphorylation of GluR1 at several phosphorylation sites in the C tail. GluR1 has four phosphorylation sites; serine 818 (S818) is phosphorylated by PKC, necessary for LTP, serine 831 (S831) is phosphorylated by CaMKII and increases the delivery of receptors to the synapse and also increases their single channel conductance, Threonine (T840) is implicated in LTP and serine 845 (S845) phosphorylated by PKA regulates open channel probability and also by cGKII, a cyclic GMP activated kinase, that increases the surface expression of GluR1. GluR1 insertion into synapse by CaMKII may induce LTP. CaMKII is a Ca/calmodulin dependent kinase that is activated upon increases in the Ca ion concentration during postsynaptic activity through NMDA receptors. The increase in GluR1-containing AMPA receptor population at the synapse results in enhancement of excitatory post synaptic potential (EPSC) which forms the basis of Long term potentiation (LTP). LTP is one form of synaptic plasticity that is involved in memory and learning. The increase in the GluR1 containing AMPA receptors and their activity leads to rise in intracellular Ca which induces signaling pathways that in turn promote switch in the type of AMPA receptors (Ca impermeable) thereby limiting the Ca increase and preventing cell death.
R-HSA-416639 (Reactome) GluR2 containing AMPA receptors are trafficked to the plasmamembrane by the activation of Ca activated PKC that binds PICK.The PICK interaction delivers GluR2 containing AMPA receptors to the Plasmamembrane. This reaction is a part of constitutive recycling of AMPA receptor that delivers the AMPA receptors from the endosome to the plasmamembrane and back to endosome from the plasmamembrane.
R-HSA-416985 (Reactome) Constitutively recycling GluR2 containing AMPA receptors in the plasmamembrane are stabilized by the action of NSF ATPase activity which disassociates PICK from GluR2 thereby retaining AMPA receptors in the plasmamembrane.
R-HSA-420688 (Reactome) Gamma-aminobutyric acid (GABA) is the chief inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through two ligand-gated channels and a the GPCR GABAB (Kaupmann K et al, 1998), which acts through G proteins to regulate potassium and calcium channels. GABAB can only bind GABA once it forms a heterodimer composed of the GABABR1 and GABABR2 receptors (White JH et al, 1998). The effects of this dimer are mediated by coupling to the G protein alpha i subunit, which inhibits adenylyl cyclase.
R-HSA-420975 (Reactome) AMPA receptors bind glutamate, released in the synaptic cleft by the presynaptic cell, in the ligand binding region in the N terminal domain.
R-HSA-420977 (Reactome) AMPA receptors bind glutamate, released in the synaptic cleft by the presynaptic cell, in the ligand binding region in the N terminal domain.
R-HSA-420980 (Reactome) Each AMPA receptor subunit binds one glutamate molecule in the ligand binding site in the N terminus. Each receptor is capable of binding four glutamate molecule, however, channel opens when two sites are occupied by the ligand and the current increases with increased ligand binding. Ca permeable AMPA receptors containing homomers of GluR1 or heteromers containing GluR1, GluR3 and GluR4 conduct Ca upon glutamate or agonist namely AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) binding. Calcium permeable AMPA receptors conduct Ca and other cations such as Na. The inonic flux leads to Ca or Na currents that leads to either increase in the intracellular Ca concentration leading to further Ca-dependent signaling or increase in depolarization that opens voltage gated channels such as NMDA receptors that require both membrane depolarization and glutamate binding for activation.
R-HSA-421007 (Reactome) GluR2 containing AMPA receptors are constitutively recycled between the endosome membrane and the plasma membrane. GRIP and PICK compete for the binding to the C tail of GluR2. Once the GluR2 containing AMPA receptors are in the plasmamembrane, phosphorylation of GluR2 at S880 by PKC causes disruption of GRIP interaction, but not PICK interaction which facilitates internalization of GluR2 containing AMPA receptors into endosomes.
R-HSA-432162 (Reactome) NMDA receptors are activated in a two step mechanism; first by the removal of the voltage dependent Mg2+ block and then by the ligand dependent activation of the unblocked NMDA receptor. At resting membrane potential NMDA receptors can not be activated by ligand alone due to the presence of Mg2+ ion in the pore of the channel. Due to the activation of other membrane resident channels that allow the influx of Na+ the membrane is depolarized which triggers the removal of Mg2+ form the NMDA receptor pore. Once the Mg2+ is expelled NMDA receptors are ready to be activated by the agonist (glutamate) and the co-agonist (glycine).
R-HSA-432164 (Reactome) NMDA receptors are activated upon binding of two ligands, glutamate and glycine.
The activation leads to Ca2+ influx into the post-synaptic cell. The local rise in the Ca2+ ion concentration further leads to activation of several Ca2+ dependent pathways leading to long term changes in the synapse.
R-HSA-432172 (Reactome) NMDA receptors require binding of two ligands; the agonist, glutamate and co-agonist, glycine. The N terminal extracellular ligand binding domain in NR1 subunits binds co-agonist glycine and the N terminal extracellular ligand binding domain in NR2 binds glutamate.
R-HSA-438037 (Reactome) Membrane depolarization occurs due to glutamate dependent activation of Ca-impermeable AMPA receptors, which permit the influx of Na+ ions. The depolarization triggers the removal of Mg2+ from the NMDA receptor pore to facilitate its activation. Therefore activation of AMPA receptors by glutamate precedes activation of NMDA receptors.
R-HSA-442715 (Reactome) Ca2+ fluxes through NMDA receptors in the post-synaptic neuron facilitate binding of Ca2+/Calmodulin to adenylate cyclase type 1, 3 or 8, resulting in its activation. Once activated, cAMP is produced which further activates PKA.
R-HSA-442724 (Reactome) CREB is phosphorylated at serine 133 by any of the four isoforms of ribosomal S6 kinase.
R-HSA-442725 (Reactome) CaMKII is fully activated upon Ca2+/Calmodulin binding. In addition to Ca2+/Calmodulin activation, CaMKII undergoes multiple autophosphorylation events leading Ca2+/Calmodulin independent activity of the enzyme.
R-HSA-442726 (Reactome) Raf is a downstream effector of ras. Raf is activated upon phosphorylation at S338, oligomerization and membrane localization. Membrane localization is facilitated by ras. Interaction of ras with raf is a necessary step but not sufficient for raf activation. Other unknown protein partner interactions are required for raf activation. Raf further activates MAP kinase.
R-HSA-442732 (Reactome) Binding of RasGRF to Ca2+/Calmodulin in the presence of high Ca2+ leads to the activation of Ras. Activation of Ras involves the exchange of GDP for GTP.
R-HSA-442737 (Reactome) MAPK/ERK is phosphorylated at threonine 185 and tyrosine 187 by membrane associated activated raf kianse leading to the activation of MAPK/ERK kinase. The activated MAPK/ERK in turn activates ribosomal S6 kinase.
R-HSA-442739 (Reactome) PDK1 activates ribosomal S6 kinase (RSK) by phosphorylating S221. The binding site for PDK1 on RSK is available after RSK phosphorylation by MAPK/ERK. PDK1 is present in the activated form at the plasma membrane where the phosphorylation occurs. The activation of RSK occurs in the cytoplasm, plasma membrane and in the nucleus where it finally activates CREB by phosphorylation.
R-HSA-442749 (Reactome) CaMKK is fully activated upon binding Ca2+/Calmodulin after intracellular Ca2+ levels increase. Once CaMKK binds Ca2+/Calmodulin it autophosphorylates, resulting in activation. CaMKK is negatively regulated by phosphorylation of S74 and T108 by PKA. Once activated CaMKK phosphorylates CaMKIV in a Ca2+/Calmodulin dependent manner.
R-HSA-442760 (Reactome) RASGRF is activated upon binding of Ca2+/Calmodulin after Ca2+ influx through the NMDA receptor.
R-HSA-443474 (Reactome) Protein kinase A has two regulatory subunits and two catalytic subunits which are held together to form the holoenzyme and is activated upon binding of cAMP within the regulatory subunits. Once cAMP binds the regulatory subunits, the catalytic subunits are released to carry out phosphorylation of CREB at serine133.
R-HSA-443475 (Reactome) CaMKII is an important regulator of neuronal plasticity. CaMKII shows distinct subcellular localization and acts quickly in a spatio-temporal manner. CaMKII shows fast synaptic localization upon synaptic activity and also nuclear localization, where it phosphorylates CREB at serine 133 to activate transcription of set of genes that results in long lasting structural changes at the synapse.
R-HSA-443480 (Reactome) Activated CaMKIV phosphorylates CREB at S133 thereby initiating the transcription of CREB regulated set of genes leading to protein synthesis and long lasting changes that underlie synaptic plasticity.
R-HSA-444253 (Reactome) Activated MAPK/ERK activates RSK in its C terminal kinase domain by sequentially phosphorylating T573, S363 and 380.
R-HSA-444792 (Reactome) Nuclear targeting of CaMKII depends on several factors including the phosphorylation in the regulatory domain of CaMKII and induction of other signal transduction pathways.
R-HSA-445367 (Reactome) CaMKII gets activated upon Ca2+ influx through the NMDA receptor and moves from plasma membrane to cytoplasm and then nucleus where it phosphorylates CREB at serine 133.
R-HSA-451283 (Reactome) Kainate receptors bind glutamate in the ligand binding domain in the extracellular, N terminal region.
R-HSA-451309 (Reactome) Kainate receptors bind glutamate in the ligand binding domain in the extracellular, N terminal region.
R-HSA-451310 (Reactome) The activation of Kainate receptors by glutamate in the postsynaptic neuron leads to influx of Na+ ions resulting in depolarization of the postsynaptic membrane.
R-HSA-451311 (Reactome) Kainate receptors that are assembled with subunits GRIK1-5, are Ca2+ permeable if GRIK1 and GRIK2 are not edited at the Q/R or other sites.
These channels permit Ca2+ upon activation by glutamate or other agonists.
R-HSA-500708 (Reactome) Kainate receptors bind glutamate in the ligand binding domain in the extracellular, N terminal region.
R-HSA-500717 (Reactome) Kainate receptor activation activates G protein coupled receptors involving the release of Ca2+ from the intracellular stores. This activity of Kainate receptors is independent of ionic influx and regulates both glutamate release by the pyramidal neurons and gama-aminobutyric acid release by the internuerons.
R-HSA-622325 (Reactome) Nicotinic acetylcholine receptors containing aplha4(2) beta2 (3) and alpha3(2) beta4(3) are selectively highly Na+ permeable upon activation of these receptors by acetylcholine.
R-HSA-622326 (Reactome) Nicotinic acetylcholine receptors are activated upon ligand binding which opens the acetylcholine channels and permits Ca2+ and Na+ ion influx depending on the subunit composition and stoichiometry of the subunits. The ratio of Ca2+ to Na+ ion influx varies making the receptors either highly Na+ permeable or Ca2+ permeable.
R-HSA-629588 (Reactome) Nicotinic acetylcholine receptors bind two molecules of ligand, acetylcholine, in the alpha beta interface in receptors containing heteromeric subunits or in the interface of 2 aplha subunits in receptors containing homomeric subunits.
R-HSA-629595 (Reactome) Acetylcholine binding activates postsynaptic acetylchloine receptors that show Ca2+ currents which facilitate the process of long term potentiation (LTP).
R-HSA-629596 (Reactome) Nicotinic acetylcholine receptors bind two molecules of ligand, acetylcholine, in the alpha beta interface in receptors containing heteromeric subunits or in the interface of 2 aplha subunits in receptors containing homomeric subunits.
R-HSA-629599 (Reactome) Nicotinic acetylcholine receptors bind two molecules of ligand, acetylcholine, in the alpha beta interface in receptors containing heteromeric subunits or in the interface of 2 aplha subunits in receptors containing homomeric subunits.
R-HSA-975340 (Reactome) The GABA(A) receptor (GABR) family belongs to the ligand-gated ion channel superfamily (LGIC). Its endogenous ligand is gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system. There are six alpha subunits (GABRA) (Garrett et al. 1988, Schofield et al. 1989, Hadingham et al. 1993, Edenberg et al. 2004, Hadingham et al. 1993, Yang et al. 1995, Wingrove et al. 1992, Hadingham et al. 1996), three beta subunits (GABRB) (Schofield et al. 1989, Hadingham et al. 1993, Wagstaff et al. 1991), 2 gamma subunits (GABRG) (Khan et al. 1993, Hadingham et al. 1995) and a theta subunit (Bonnert et al. 1999) characterised to date. GABA(A) functions as a heteropentamer, the most common structure being 2 alpha subunits, 2 beta subunits and a gamma subunit (2GABRA:2GABRB:GABRG). An alternative heteropentamer with much less affinity for GABA is 2GABRA:GABRB:GABRG:GABRQ (Bonnert et al. 1999). Upon binding of GABA, both GABR complexes conduct chloride ions through their pore, resulting in hyperpolarisation of the neuron. This causes an inhibitory effect on neurotransmission by reducing the chances of a successful action potential occurring.
R-HSA-975449 (Reactome) The GABA(A)-rho receptor (GABRR) is expressed in many areas of the brain, but in contrast to other GABA(A) receptors, has especially high expression in the retina. It is functional as a homopentamer and is permeable to chloride ions when GABA binds to it (Cutting et al. 1991, Cutting et al. 1992, Bailey et al. 1990).
Ras:GDPR-HSA-442732 (Reactome)
Ras:GTPArrowR-HSA-442732 (Reactome)
RasGRF:Ca/calmodulinArrowR-HSA-442760 (Reactome)
RasGRF:Ca/calmodulinmim-catalysisR-HSA-442732 (Reactome)
RasGRFR-HSA-442760 (Reactome)
RasGTP-B raf compexR-HSA-442726 (Reactome)
Ribosomal S6 kinaseR-HSA-444253 (Reactome)
TARP-PSD95-Mdm2ArrowR-HSA-416320 (Reactome)
TARP-PSD95-Mdm2R-HSA-416320 (Reactome)
cAMPArrowR-HSA-442715 (Reactome)
kaiante ReceptorsArrowR-HSA-451311 (Reactome)
kaiante ReceptorsR-HSA-451283 (Reactome)
kaiante Receptorsmim-catalysisR-HSA-451311 (Reactome)
p-CAMKK1ArrowR-HSA-442749 (Reactome)
p-S133-CREB1ArrowR-HSA-442724 (Reactome)
p-S133-CREB1ArrowR-HSA-443474 (Reactome)
p-S133-CREB1ArrowR-HSA-443475 (Reactome)
p-S133-CREB1ArrowR-HSA-443480 (Reactome)
p-S338-RAF1mim-catalysisR-HSA-442737 (Reactome)
p-T185,Y187-MAPK1ArrowR-HSA-442737 (Reactome)
p-T185,Y187-MAPK1mim-catalysisR-HSA-444253 (Reactome)
phospho-CaMK IV:CalmodulinArrowR-HSA-111915 (Reactome)
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