XBP1(S) activates chaperone genes (Homo sapiens)

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3, 9, 10, 12, 14335153333332, 4, 733310333333333331, 116, 8, 13333333333333endosomelysosomal lumenendoplasmic reticulum membraneGolgi lumennucleoplasmcytosolendoplasmic reticulum lumenmitochondrial matrixADD1EDEM1 geneACADVL geneADPPDIA6ATP6V0D1 geneKDELR3SULT1A3 geneDNAJC3SERP1GOSR2 geneFKBP14DNAJB11SRPRPLA2G4BDDX11H2OTLN1SULT1A3TPP1EDEM1CXXC1GFPT1SEC31AHDGF geneZBTB17SYVN1(1-617)CTDSP2SEC61G HYOU1YIF1APREBPLA2G4B geneSEC63 SEC61G ZBTB17 geneDNAJB11 geneLMNA(1-664)SEC61A1 DCTN1 genePPP2R5BWIPI1C19orf10 geneGFPT1 genePDIA5ARFGAP1TATDN2 geneSERP1 GSK3ASEC31A geneARFGAP1 geneTSPYL2 geneSEC61B WFS1KLHDC3SYVN1 geneTPP1 geneKDELR3 geneSEC61B EXTL3SEC62 CUL7SEC61A2 SEC61A1 SERP1 SRPRBCXXC1 geneSHC1XBP1-2SEC61A2 DNAJB9WIPI1 geneTLN1 geneFKBP14 geneDCTN1DNAJB9 geneYIF1A genePDIA5 geneASNA1ATPDNAJC3 geneCTDSP2 geneTSPYL2SEC62 PPiSSR1 geneSEC63 SHC1 geneGSK3A geneWFS1 geneSRPRB geneC19orf10KLHDC3 genePDIA6 geneSSR1EXTL3 geneSERP1 genePPP2R5B geneDDX11 geneSRPR geneATP6V0D1HYOU1 geneGOSR2ASNA1 productsLMNA genePREB geneASNA1 substratesTATDN2ADD1 geneHDGFACADVLCUL7 gene


Description

Xbp-1 (S) binds the sequence CCACG in ER Stress Responsive Elements (ERSE, consensus sequence CCAAT (N)9 CCACG) located upstream from many genes. The ubiquitous transcription factor NF-Y, a heterotrimer, binds the CCAAT portion of the ERSE and together the IRE1-alpha: NF-Y complex activates transcription of a set of chaperone genes including DNAJB9, EDEM, RAMP4, p58IPK, and others. This results in an increase in protein folding activity in the ER. View original pathway at:Reactome.

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Bibliography

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  1. Lee AH, Iwakoshi NN, Glimcher LH.; ''XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response.''; PubMed Europe PMC Scholia
  2. Acosta-Alvear D, Zhou Y, Blais A, Tsikitis M, Lents NH, Arias C, Lennon CJ, Kluger Y, Dynlacht BD.; ''XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks.''; PubMed Europe PMC Scholia
  3. Wuyts W, Van Hul W, Hendrickx J, Speleman F, Wauters J, De Boulle K, Van Roy N, Van Agtmael T, Bossuyt P, Willems PJ.; ''Identification and characterization of a novel member of the EXT gene family, EXTL2.''; PubMed Europe PMC Scholia
  4. Saito T, Seki N, Yamauchi M, Tsuji S, Hayashi A, Kozuma S, Hori T.; ''Structure, chromosomal location, and expression profile of EXTR1 and EXTR2, new members of the multiple exostoses gene family.''; PubMed Europe PMC Scholia
  5. Yu M, Haslam RH, Haslam DB.; ''HEDJ, an Hsp40 co-chaperone localized to the endoplasmic reticulum of human cells.''; PubMed Europe PMC Scholia
  6. Yamaguchi A, Hori O, Stern DM, Hartmann E, Ogawa S, Tohyama M.; ''Stress-associated endoplasmic reticulum protein 1 (SERP1)/Ribosome-associated membrane protein 4 (RAMP4) stabilizes membrane proteins during stress and facilitates subsequent glycosylation.''; PubMed Europe PMC Scholia
  7. Jordan PA, Stevens JM, Hubbard GP, Barrett NE, Sage T, Authi KS, Gibbins JM.; ''A role for the thiol isomerase protein ERP5 in platelet function.''; PubMed Europe PMC Scholia
  8. Hayano T, Kikuchi M.; ''Cloning and sequencing of the cDNA encoding human P5.''; PubMed Europe PMC Scholia
  9. Kikuchi M, Doi E, Tsujimoto I, Horibe T, Tsujimoto Y.; ''Functional analysis of human P5, a protein disulfide isomerase homologue.''; PubMed Europe PMC Scholia
  10. Kakiuchi C, Ishiwata M, Hayashi A, Kato T.; ''XBP1 induces WFS1 through an endoplasmic reticulum stress response element-like motif in SH-SY5Y cells.''; PubMed Europe PMC Scholia
  11. Korth MJ, Lyons CN, Wambach M, Katze MG.; ''Cloning, expression, and cellular localization of the oncogenic 58-kDa inhibitor of the RNA-activated human and mouse protein kinase.''; PubMed Europe PMC Scholia
  12. Wise CA, Clines GA, Massa H, Trask BJ, Lovett M.; ''Identification and localization of the gene for EXTL, a third member of the multiple exostoses gene family.''; PubMed Europe PMC Scholia
  13. Yamamoto K, Suzuki N, Wada T, Okada T, Yoshida H, Kaufman RJ, Mori K.; ''Human HRD1 promoter carries a functional unfolded protein response element to which XBP1 but not ATF6 directly binds.''; PubMed Europe PMC Scholia
  14. Li G, Luna C, Qiu J, Epstein DL, Gonzalez P.; ''Role of miR-204 in the regulation of apoptosis, endoplasmic reticulum stress response, and inflammation in human trabecular meshwork cells.''; PubMed Europe PMC Scholia
  15. Yoshida H, Oku M, Suzuki M, Mori K.; ''pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response.''; PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
114932view16:45, 25 January 2021ReactomeTeamReactome version 75
113377view11:45, 2 November 2020ReactomeTeamReactome version 74
112582view15:55, 9 October 2020ReactomeTeamReactome version 73
101497view11:36, 1 November 2018ReactomeTeamreactome version 66
101034view21:17, 31 October 2018ReactomeTeamreactome version 65
100567view19:51, 31 October 2018ReactomeTeamreactome version 64
100116view16:36, 31 October 2018ReactomeTeamreactome version 63
99666view15:06, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99264view12:45, 31 October 2018ReactomeTeamreactome version 62
94043view13:53, 16 August 2017ReactomeTeamreactome version 61
93668view11:30, 9 August 2017ReactomeTeamreactome version 61
88353view16:23, 1 August 2016FehrhartOntology Term : 'protein folding pathway' added !
88352view16:23, 1 August 2016FehrhartOntology Term : 'transcription pathway' added !
86791view09:26, 11 July 2016ReactomeTeamreactome version 56
83243view10:28, 18 November 2015ReactomeTeamVersion54
82409view13:10, 29 September 2015ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACADVL geneGeneProductENSG00000072778 (Ensembl)
ACADVLProteinP49748 (Uniprot-TrEMBL)
ADD1 geneGeneProductENSG00000087274 (Ensembl)
ADD1ProteinP35611 (Uniprot-TrEMBL)
ADPMetaboliteCHEBI:16761 (ChEBI)
ARFGAP1 geneGeneProductENSG00000101199 (Ensembl)
ARFGAP1ProteinQ8N6T3 (Uniprot-TrEMBL)
ASNA1 productsComplexR-HSA-5250586 (Reactome)
ASNA1 substratesComplexR-HSA-5250567 (Reactome)
ASNA1ProteinO43681 (Uniprot-TrEMBL)
ATP6V0D1 geneGeneProductENSG00000159720 (Ensembl)
ATP6V0D1ProteinP61421 (Uniprot-TrEMBL)
ATPMetaboliteCHEBI:15422 (ChEBI)
C19orf10 geneGeneProductENSG00000074842 (Ensembl)
C19orf10ProteinQ969H8 (Uniprot-TrEMBL)
CTDSP2 geneGeneProductENSG00000175215 (Ensembl)
CTDSP2ProteinO14595 (Uniprot-TrEMBL)
CUL7 geneGeneProductENSG00000044090 (Ensembl)
CUL7ProteinQ14999 (Uniprot-TrEMBL)
CXXC1 geneGeneProductENSG00000154832 (Ensembl)
CXXC1ProteinQ9P0U4 (Uniprot-TrEMBL)
DCTN1 geneGeneProductENSG00000204843 (Ensembl)
DCTN1ProteinQ14203 (Uniprot-TrEMBL)
DDX11 geneGeneProductENSG00000013573 (Ensembl)
DDX11ProteinQ96FC9 (Uniprot-TrEMBL)
DNAJB11 geneGeneProductENSG00000090520 (Ensembl)
DNAJB11ProteinQ9UBS4 (Uniprot-TrEMBL)
DNAJB9 geneGeneProductENSG00000128590 (Ensembl)
DNAJB9ProteinQ9UBS3 (Uniprot-TrEMBL)
DNAJC3 geneGeneProductENSG00000102580 (Ensembl)
DNAJC3ProteinQ13217 (Uniprot-TrEMBL)
EDEM1 geneGeneProductENSG00000134109 (Ensembl)
EDEM1ProteinQ92611 (Uniprot-TrEMBL)
EXTL3 geneGeneProductENSG00000012232 (Ensembl)
EXTL3ProteinO43909 (Uniprot-TrEMBL)
FKBP14 geneGeneProductENSG00000106080 (Ensembl)
FKBP14ProteinQ9NWM8 (Uniprot-TrEMBL)
GFPT1 geneGeneProductENSG00000198380 (Ensembl)
GFPT1ProteinQ06210 (Uniprot-TrEMBL)
GOSR2 geneGeneProductENSG00000108433 (Ensembl)
GOSR2ProteinO14653 (Uniprot-TrEMBL)
GSK3A geneGeneProductENSG00000105723 (Ensembl)
GSK3AProteinP49840 (Uniprot-TrEMBL)
H2OMetaboliteCHEBI:15377 (ChEBI)
HDGF geneGeneProductENSG00000143321 (Ensembl)
HDGFProteinP51858 (Uniprot-TrEMBL)
HYOU1 geneGeneProductENSG00000149428 (Ensembl)
HYOU1ProteinQ9Y4L1 (Uniprot-TrEMBL)
KDELR3 geneGeneProductENSG00000100196 (Ensembl)
KDELR3ProteinO43731 (Uniprot-TrEMBL)
KLHDC3 geneGeneProductENSG00000124702 (Ensembl)
KLHDC3ProteinQ9BQ90 (Uniprot-TrEMBL)
LMNA geneGeneProductENSG00000160789 (Ensembl)
LMNA(1-664)ProteinP02545 (Uniprot-TrEMBL)
PDIA5 geneGeneProductENSG00000065485 (Ensembl)
PDIA5ProteinQ14554 (Uniprot-TrEMBL)
PDIA6 geneGeneProductENSG00000143870 (Ensembl)
PDIA6ProteinQ15084 (Uniprot-TrEMBL)
PLA2G4B geneGeneProductENSG00000243708 (Ensembl)
PLA2G4BProteinP0C869 (Uniprot-TrEMBL)
PPP2R5B geneGeneProductENSG00000068971 (Ensembl)
PPP2R5BProteinQ15173 (Uniprot-TrEMBL)
PPiMetaboliteCHEBI:29888 (ChEBI)
PREB geneGeneProductENSG00000138073 (Ensembl)
PREBProteinQ9HCU5 (Uniprot-TrEMBL)
SEC31A geneGeneProductENSG00000138674 (Ensembl)
SEC31AProteinO94979 (Uniprot-TrEMBL)
SEC61A1 ProteinP61619 (Uniprot-TrEMBL)
SEC61A2 ProteinQ9H9S3 (Uniprot-TrEMBL)
SEC61B ProteinP60468 (Uniprot-TrEMBL)
SEC61G ProteinP60059 (Uniprot-TrEMBL)
SEC62 ProteinQ99442 (Uniprot-TrEMBL)
SEC63 ProteinQ9UGP8 (Uniprot-TrEMBL)
SERP1 ProteinQ9Y6X1 (Uniprot-TrEMBL)
SERP1 geneGeneProductENSG00000120742 (Ensembl)
SERP1ProteinQ9Y6X1 (Uniprot-TrEMBL)
SHC1 geneGeneProductENSG00000160691 (Ensembl)
SHC1ProteinP29353 (Uniprot-TrEMBL)
SRPR geneGeneProductENSG00000182934 (Ensembl)
SRPRB geneGeneProductENSG00000144867 (Ensembl)
SRPRBProteinQ9Y5M8 (Uniprot-TrEMBL)
SRPRProteinP08240 (Uniprot-TrEMBL)
SSR1 geneGeneProductENSG00000124783 (Ensembl)
SSR1ProteinP43307 (Uniprot-TrEMBL)
SULT1A3 geneGeneProductENSG00000261052 (Ensembl)
SULT1A3ProteinP0DMM9 (Uniprot-TrEMBL)
SYVN1 geneGeneProductENSG00000162298 (Ensembl)
SYVN1(1-617)ProteinQ86TM6 (Uniprot-TrEMBL)
TATDN2 geneGeneProductENSG00000157014 (Ensembl)
TATDN2ProteinQ93075 (Uniprot-TrEMBL)
TLN1 geneGeneProductENSG00000137076 (Ensembl)
TLN1ProteinQ9Y490 (Uniprot-TrEMBL)
TPP1 geneGeneProductENSG00000166340 (Ensembl)
TPP1ProteinO14773 (Uniprot-TrEMBL)
TSPYL2 geneGeneProductENSG00000184205 (Ensembl)
TSPYL2ProteinQ9H2G4 (Uniprot-TrEMBL)
WFS1 geneGeneProductENSG00000109501 (Ensembl)
WFS1ProteinO76024 (Uniprot-TrEMBL)
WIPI1 geneGeneProductENSG00000070540 (Ensembl)
WIPI1ProteinQ5MNZ9 (Uniprot-TrEMBL)
XBP1-2ProteinP17861-2 (Uniprot-TrEMBL)
YIF1A geneGeneProductENSG00000174851 (Ensembl)
YIF1AProteinO95070 (Uniprot-TrEMBL)
ZBTB17 geneGeneProductENSG00000116809 (Ensembl)
ZBTB17ProteinQ13105 (Uniprot-TrEMBL)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
ACADVL geneR-HSA-1791069 (Reactome)
ACADVLArrowR-HSA-1791069 (Reactome)
ADD1 geneR-HSA-1791076 (Reactome)
ADD1ArrowR-HSA-1791076 (Reactome)
ADPArrowR-HSA-5250579 (Reactome)
ARFGAP1 geneR-HSA-1791064 (Reactome)
ARFGAP1ArrowR-HSA-1791064 (Reactome)
ASNA1 productsArrowR-HSA-5250579 (Reactome)
ASNA1 substratesR-HSA-5250579 (Reactome)
ASNA1mim-catalysisR-HSA-5250579 (Reactome)
ATP6V0D1 geneR-HSA-1791184 (Reactome)
ATP6V0D1ArrowR-HSA-1791184 (Reactome)
ATPR-HSA-5250579 (Reactome)
C19orf10 geneR-HSA-1791102 (Reactome)
C19orf10ArrowR-HSA-1791102 (Reactome)
CTDSP2 geneR-HSA-1791130 (Reactome)
CTDSP2ArrowR-HSA-1791130 (Reactome)
CUL7 geneR-HSA-1791058 (Reactome)
CUL7ArrowR-HSA-1791058 (Reactome)
CXXC1 geneR-HSA-1791158 (Reactome)
CXXC1ArrowR-HSA-1791158 (Reactome)
DCTN1 geneR-HSA-1791092 (Reactome)
DCTN1ArrowR-HSA-1791092 (Reactome)
DDX11 geneR-HSA-1791116 (Reactome)
DDX11ArrowR-HSA-1791116 (Reactome)
DNAJB11 geneR-HSA-1791075 (Reactome)
DNAJB11ArrowR-HSA-1791075 (Reactome)
DNAJB9 geneR-HSA-1791124 (Reactome)
DNAJB9ArrowR-HSA-1791124 (Reactome)
DNAJC3 geneR-HSA-1791157 (Reactome)
DNAJC3ArrowR-HSA-1791157 (Reactome)
EDEM1 geneR-HSA-1791155 (Reactome)
EDEM1ArrowR-HSA-1791155 (Reactome)
EXTL3 geneR-HSA-1791144 (Reactome)
EXTL3ArrowR-HSA-1791144 (Reactome)
FKBP14 geneR-HSA-1791114 (Reactome)
FKBP14ArrowR-HSA-1791114 (Reactome)
GFPT1 geneR-HSA-1791088 (Reactome)
GFPT1ArrowR-HSA-1791088 (Reactome)
GOSR2 geneR-HSA-1791154 (Reactome)
GOSR2ArrowR-HSA-1791154 (Reactome)
GSK3A geneR-HSA-1791054 (Reactome)
GSK3AArrowR-HSA-1791054 (Reactome)
H2OR-HSA-5250579 (Reactome)
HDGF geneR-HSA-1791112 (Reactome)
HDGFArrowR-HSA-1791112 (Reactome)
HYOU1 geneR-HSA-1791066 (Reactome)
HYOU1ArrowR-HSA-1791066 (Reactome)
KDELR3 geneR-HSA-1791123 (Reactome)
KDELR3ArrowR-HSA-1791123 (Reactome)
KLHDC3 geneR-HSA-1791177 (Reactome)
KLHDC3ArrowR-HSA-1791177 (Reactome)
LMNA geneR-HSA-1791128 (Reactome)
LMNA(1-664)ArrowR-HSA-1791128 (Reactome)
PDIA5 geneR-HSA-1791122 (Reactome)
PDIA5ArrowR-HSA-1791122 (Reactome)
PDIA6 geneR-HSA-1791131 (Reactome)
PDIA6ArrowR-HSA-1791131 (Reactome)
PLA2G4B geneR-HSA-1791071 (Reactome)
PLA2G4BArrowR-HSA-1791071 (Reactome)
PPP2R5B geneR-HSA-1791096 (Reactome)
PPP2R5BArrowR-HSA-1791096 (Reactome)
PPiArrowR-HSA-5250579 (Reactome)
PREB geneR-HSA-1791083 (Reactome)
PREBArrowR-HSA-1791083 (Reactome)
R-HSA-1791054 (Reactome) The GSK3A gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791057 (Reactome) The TSPYL2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791058 (Reactome) The Cullin-7 (CUL7) gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791060 (Reactome) The SRPRB gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791064 (Reactome) The GAP gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791066 (Reactome) The HYOU1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791069 (Reactome) The ACADVL gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791071 (Reactome) The PLA2GB4B gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791075 (Reactome) The DNAJB11 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791076 (Reactome) The ADD1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791083 (Reactome) The Sec12 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791084 (Reactome) The SYVN1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791088 (Reactome) The GFPT1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791092 (Reactome) The DCTN1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791096 (Reactome) The PPP2R5B gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791102 (Reactome) The C19orf10 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791108 (Reactome) The SULT1A3 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791112 (Reactome) The HDGF gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791114 (Reactome) The FKBP14 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791116 (Reactome) The DDX11 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791122 (Reactome) The PDIA5 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791123 (Reactome) The KDELR3 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791124 (Reactome) The DNAJB9 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791128 (Reactome) The LMNA gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791130 (Reactome) The CTDSP2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791131 (Reactome) The PDIA6 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791133 (Reactome) The Sec31A gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791134 (Reactome) The SHC1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791137 (Reactome) The Talin-1 (TLN1) gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791138 (Reactome) The TPP1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791139 (Reactome) The SRPR gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791143 (Reactome) The YIF1A gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791144 (Reactome) The EXTL3 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791154 (Reactome) The GOSR2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791155 (Reactome) The EDEM gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791156 (Reactome) The TATDN2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791157 (Reactome) The p58IPK (DNAJC3) gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791158 (Reactome) The CXXC1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791164 (Reactome) The SSR1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791167 (Reactome) The RAMP4 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791169 (Reactome) The WFS1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791172 (Reactome) The WIPI1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791177 (Reactome) The KLHDC3 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791184 (Reactome) The ATP6VOD1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1791186 (Reactome) The ZBTB17 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-5250579 (Reactome) Many tail-anchored (TA) proteins insert post-translationally into the endoplasmic reticulum (ER) membrane via a highly conserved C-terminal transmembrane domain. This domain is recognised by the homodimeric ATPase ASNA1, resident on the ER membrane, which delivers TA proteins to the ER membrane, ready for insertion. This process requires the hydrolysis of ATP to drive the dimeric ASNA1 towards a closed state and to facilitate ER membrane insertion of TA proteins. TA proteins which have been shown to be targeted in this way are stress-associated endoplasmic reticulum protein 1 (SERP1 aka RAMP4) and the SEC translocon complex (Stefanovic & Hegde 2007, Favaloro et al. 2008, Favaloro et al. 2010).
SEC31A geneR-HSA-1791133 (Reactome)
SEC31AArrowR-HSA-1791133 (Reactome)
SERP1 geneR-HSA-1791167 (Reactome)
SERP1ArrowR-HSA-1791167 (Reactome)
SHC1 geneR-HSA-1791134 (Reactome)
SHC1ArrowR-HSA-1791134 (Reactome)
SRPR geneR-HSA-1791139 (Reactome)
SRPRArrowR-HSA-1791139 (Reactome)
SRPRB geneR-HSA-1791060 (Reactome)
SRPRBArrowR-HSA-1791060 (Reactome)
SSR1 geneR-HSA-1791164 (Reactome)
SSR1ArrowR-HSA-1791164 (Reactome)
SULT1A3 geneR-HSA-1791108 (Reactome)
SULT1A3ArrowR-HSA-1791108 (Reactome)
SYVN1 geneR-HSA-1791084 (Reactome)
SYVN1(1-617)ArrowR-HSA-1791084 (Reactome)
TATDN2 geneR-HSA-1791156 (Reactome)
TATDN2ArrowR-HSA-1791156 (Reactome)
TLN1 geneR-HSA-1791137 (Reactome)
TLN1ArrowR-HSA-1791137 (Reactome)
TPP1 geneR-HSA-1791138 (Reactome)
TPP1ArrowR-HSA-1791138 (Reactome)
TSPYL2 geneR-HSA-1791057 (Reactome)
TSPYL2ArrowR-HSA-1791057 (Reactome)
WFS1 geneR-HSA-1791169 (Reactome)
WFS1ArrowR-HSA-1791169 (Reactome)
WIPI1 geneR-HSA-1791172 (Reactome)
WIPI1ArrowR-HSA-1791172 (Reactome)
XBP1-2ArrowR-HSA-1791054 (Reactome)
XBP1-2ArrowR-HSA-1791057 (Reactome)
XBP1-2ArrowR-HSA-1791058 (Reactome)
XBP1-2ArrowR-HSA-1791060 (Reactome)
XBP1-2ArrowR-HSA-1791064 (Reactome)
XBP1-2ArrowR-HSA-1791066 (Reactome)
XBP1-2ArrowR-HSA-1791069 (Reactome)
XBP1-2ArrowR-HSA-1791071 (Reactome)
XBP1-2ArrowR-HSA-1791075 (Reactome)
XBP1-2ArrowR-HSA-1791076 (Reactome)
XBP1-2ArrowR-HSA-1791083 (Reactome)
XBP1-2ArrowR-HSA-1791084 (Reactome)
XBP1-2ArrowR-HSA-1791088 (Reactome)
XBP1-2ArrowR-HSA-1791092 (Reactome)
XBP1-2ArrowR-HSA-1791096 (Reactome)
XBP1-2ArrowR-HSA-1791102 (Reactome)
XBP1-2ArrowR-HSA-1791108 (Reactome)
XBP1-2ArrowR-HSA-1791112 (Reactome)
XBP1-2ArrowR-HSA-1791114 (Reactome)
XBP1-2ArrowR-HSA-1791116 (Reactome)
XBP1-2ArrowR-HSA-1791122 (Reactome)
XBP1-2ArrowR-HSA-1791123 (Reactome)
XBP1-2ArrowR-HSA-1791124 (Reactome)
XBP1-2ArrowR-HSA-1791128 (Reactome)
XBP1-2ArrowR-HSA-1791130 (Reactome)
XBP1-2ArrowR-HSA-1791131 (Reactome)
XBP1-2ArrowR-HSA-1791133 (Reactome)
XBP1-2ArrowR-HSA-1791134 (Reactome)
XBP1-2ArrowR-HSA-1791137 (Reactome)
XBP1-2ArrowR-HSA-1791138 (Reactome)
XBP1-2ArrowR-HSA-1791139 (Reactome)
XBP1-2ArrowR-HSA-1791143 (Reactome)
XBP1-2ArrowR-HSA-1791144 (Reactome)
XBP1-2ArrowR-HSA-1791154 (Reactome)
XBP1-2ArrowR-HSA-1791155 (Reactome)
XBP1-2ArrowR-HSA-1791156 (Reactome)
XBP1-2ArrowR-HSA-1791157 (Reactome)
XBP1-2ArrowR-HSA-1791158 (Reactome)
XBP1-2ArrowR-HSA-1791164 (Reactome)
XBP1-2ArrowR-HSA-1791167 (Reactome)
XBP1-2ArrowR-HSA-1791169 (Reactome)
XBP1-2ArrowR-HSA-1791172 (Reactome)
XBP1-2ArrowR-HSA-1791177 (Reactome)
XBP1-2ArrowR-HSA-1791184 (Reactome)
XBP1-2ArrowR-HSA-1791186 (Reactome)
YIF1A geneR-HSA-1791143 (Reactome)
YIF1AArrowR-HSA-1791143 (Reactome)
ZBTB17 geneR-HSA-1791186 (Reactome)
ZBTB17ArrowR-HSA-1791186 (Reactome)
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