O-linked glycosylation (Homo sapiens)

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3, 2918107, 8, 1413, 15, 16, 21, 27...6, 191112, 2020, 22, 2324, 321217, 24, 254, 5, 9, 2611endoplasmic reticulum lumencytosolGolgi lumenCore 2a (MUC1) Disialyl T-antigen (MUC19) glc-fuc-SEMA5B(27-1093) extended Core 6 (MUC21) Core 3 (MUC7) C1GALT1C1 glc-fuc-THBS1 Core 3 (MUC19) Sialyl Tn antigen (MUC21) Disialyl T-antigen (MUC15) C1GALT1 ADAMTS8 T-antigen (MUC13) GalNAc-MUC20 Core 3 (MUC5AC) MUC16 Sialyl Tn antigen (MUC6) Core 4 (MUC4) Sialyl-2,3 T-antigen (MUCL1) T-antigen (MUC2) O-fuc-ADAMTS2 ST3GAL1 GALNT12 MUC20 Core 2a (MUC6) Sialyl Tn antigen (MUC5AC) Sialyl Tn antigen (MUC15) B4GALT5 GalNAc-MUC5B(26-5703) Sialyl Tn antigen (MUC3A) glc-fuc-ADAMTSL2 GalNAc-MUC6(23-2392) O-fuc-ADAMTS5 T-antigen (MUC1) GALNT4 T-antigen (MUC16) Disialyl T-antigen (MUC20) Core 2a (MUC4) Core 1 mucinsO-fuc-THSD7A CMPglc-fuc-ADAMTS8 SEMA5A UDP-GlcNAcO-fuc-ADAMTS14 MUC5B(26-5703) extended Core 6 (MUC16) O-fuc-ADAMTS7 Core 5 (MUC20) Disialyl T-antigen (MUC16) CMP-Neu5AcADAMTS7 GALNTL5 Sialyl T-antigen (MUC13) Sialyl-2,3 TantigensGCNT6 Disialyl T-antigen (MUC12) T-antigen (MUC5AC) glc-fuc-THSD7A Core 8 (MUC15) Core 7 mucinsO-fuc-SEMA5A UDP-GlcNAcSialyl Tn antigen (MUC16) glc-fuc-ADAMTS6 Core 8 (MUC3B) Disialyl T-antigen (MUC21) MucinsGALNT16 Core 2 (MUC6) Core 2 (MUC12) Sialyl-2,3 T-antigen (MUC21) T-antigen (MUC15) GALNT7 B3GNT4 Core 7 (MUC21) GALNTL6 ADAMTS4 extended Core 6 (MUC1) Core 2 (MUC2) Core 6 (MUCL1) Core 6 (MUC16) Core 2 (MUC5AC) Core 8 (MUC7) O-fuc-ADAMTS18 O-fuc-ADAMTS10 Core 2 (MUC16) Core 7 (MUC7) Core 5 (MUC15) Disialyl T-antigen (MUC2) Core 3 (MUC2) T-antigen (MUC7) GalNAc-MUC7 GalNAc-MUC13 MUC3A ST6GAL1THBS1 Tn antigensB3GNT6 GalNAc-MUC15 O-fuc-ADAMTS3 glc-fuc-ADAMTS14 Core 4 (MUCL1) Sialyl T-antigen (MUC2) Sialyl T-antigen (MUC5B) Sialyl-2,3 T-antigen (MUC16) extended Core 6 (MUCL1) Core 4 mucinsglc-fuc-THBS2 Core 8 (MUC4) ADAMTS1 glc-fuc-ADAMTS19 Disialyl T antigensADAMTS12 CMP-Neu5AcMUC4(29-2169) Core 6 (MUC19) Sialyl-2,3 T-antigen (MUC7) Core 3 (MUC20) ADAMTS13 GalNAc-MUC5AC Core 6 (MUC20) GALNT18 Core 2 (MUCL1) O-fuc-ADAMTS12 THSD7B Core 5 mucinsO-fuc-ADAMTS8 glc-fuc-SPON2 Sialyl-2,3 T-antigen (MUC1) UDPSialyl T-antigen (MUC3A) ADAMTSL5 T-antigen (MUC3B) Core 3 (MUC21) Sialyl Tn antigen (MUCL1) glc-fuc-SEMA5A B3GALTLB3GNT9 Sialyl-2,3 T-antigen (MUC2) Disialyl T-antigen (MUC17) Core 8 (MUC2) extended Core 6 (MUC3A) MUC5AC Core 7 (MUC3A) Sialyl-2,3 T-antigen (MUC12) A4GNTGALNT11 WBSCR17 ST6GALNAC3/4Core 2a (MUC2) GCNT4 Sialyl T-antigen (MUC6) Core 2a (MUC3A) GalNAc-MUC3B(?-901) ST3GAL3 Core 2a (MUC19) CMPCore 5 (MUC2) Core 3 mucinsB4GALT6 GalNAc-MUC21 glc-fuc-ADAMTS13 Core 2a (MUC20) T-antigen (MUC12) UDP-GalCore 8 (MUC16) T-antigen (MUC4) GalNAc-MUC12 B3GNT5 Core 5 (MUC5B) ADAMTSL2 Core 6 (MUC13) Core 2 (MUC4) extended Core 6 (MUC20) Core 6 (MUC5B) Core 2 (MUC5B) Core 7 (MUC3B) T-antigen (MUC17) T-antigen (MUC20) MUC13 Core 2a (MUCL1) Core 5 (MUC1) ADAMTS9 UDPO-fuc-ADAMTSL2 Disialyl T-antigen (MUC5AC) Core 2a (MUC21) ADAMTS14 GALNT:C1GALT1C1Sialyl Tn antigen (MUC7) ADAMTS20 O-fuc-ADAMTS1 UDP-GalGalNAc-MUC4(29-2169) Sialyl Tn antigen (MUC1) glc-fuc-ADAMTS9 THSD4 ADAMTS10 Core 4 (MUC16) extended Core 6 (MUC4) extended Core 6 (MUC15) O-fuc-ADAMTS16 T-antigen (MUCL1) Core 8 (MUC17) Core 3 (MUC3B) Core 3 (MUC17) THSD7A Core 5 (MUC3B) Core 3 (MUCL1) glc-fuc-THSD7B ADAMTS6 glc-fuc-ADAMTSL3 GALNT2(1-571) Core 3 (MUC5B) Core 8 (MUC5B) Disialyl T-antigen (MUC1) GCNTsCore 7 (MUC4) Core 7 (MUC2) Core 6 (MUC4) ADAMTS5 Core 8 (MUC5AC) Sialyl Tn antigen (MUC3B) Core 5 (MUC16) MUC1(24-1255) UDP-GalGalNAc-MUC16 glc-fuc-ADAMTSL4 Core 4 (MUC12) Core 4 (MUC5B) UDPUDPCore 5 (MUC3A) Core 5 (MUC17) B3GNT8 O-fuc-CFP CMPextended Core 6 (MUC2) B3GNTsextended Core 6 (MUC17) UDPCMP-Neu5AcSialyl-2,3 T-antigen (MUC6) B3GNT2 glc-fuc-ADAMTSL5 Core 4 (MUC21) MUC17 Core 7 (MUC16) MUC6(23-2392) Core 7 (MUC19) Core 8 (MUC21) Core 2a (MUC7) Sialyl-2,3 T-antigen (MUC15) Core 3 (MUC15) Sialyl Tn antigen (MUC12) Core 4 (MUC2) UDPCore 7 (MUC15) T-antigen (MUC21) Core 8 mucinsADAMTS2 Core 4 (MUC19) B3GNTL1 Core 4 (MUC15) ST6GALNAC3 Core 6 (MUC7) Sialyl-2,6 TantigensSialyl T-antigen (MUC4) T-antigen (MUC19) GalNAc-MUC19(?-6254) glc-fuc-ADAMTS5 Core 6 (MUC2) O-fuc-SBSPON Core 4 (MUC17) ADAMTS18 Sialyl Tn antigen (MUC4) Core 5 (MUC21) glc-fuc-proteinsCore 6 (MUC1) Core 4 (MUC13) O-fuc-ADAMTSL3 Core 7 (MUC12) O-fuc-ADAMTS20 GALNT3 Core 2 (MUC21) Core 7 (MUCL1) ADAMTS3 extended Core 6 (MUC19) GCNT3 Disialyl T-antigen (MUC6) extended Core 6 (MUC5B) Core 2a (MUC3B) Core 2 (MUC7) Core 6 mucinsglc-fuc-SSPPO O-fuc-ADAMTSL5 GALNT13 Core 2a (MUC16) Sialyl Tn antigen (MUC20) Core 5 (MUCL1) Core 3 (MUC12) SEMA5B(27-1093) Core 6 (MUC3B) Sialyl T-antigen (MUC15) Core 2 (MUC1) O-fuc-SSPO GALNT8 glc-fuc-THSD1 O-fuc-THSD4 T-antigen (MUC6) glc-fuc-ADAMTS20 GALNT5 Core 8 (MUC20) O-fuc-THSD7B O-fuc-ADAMTSL1 Core 6 (MUC17) ST3GAL4 glc-fuc-ADAMTS16 O-fuc-THBS1 Core 5 (MUC12) GCNT7 Core 2 mucinsDisialyl T-antigen (MUCL1) Core 2 (MUC15) GalNAc-MUCL1 Disialyl T-antigen (MUC5B) SBSPON ADAMTS17 Sialyl T-antigen (MUC5AC) Core 5 (MUC6) GCNT1 Core 5 (MUC4) UDP-GlcGALNT10 Sialyl Tn antigensSialyl T-antigen (MUC20) Core 7 (MUC1) Sialyl Tn antigen (MUC5B) extended Core 6 (MUC6) ADAMTS15 Core 5 (MUC7) Core 8 (MUC6) Core 3 (MUC4) MUC12 ADAMTSL1 Sialyl T-antigen (MUC21) Sialyl-2,3 T-antigen (MUC17) CMPSialyl T-antigen (MUC3B) Core 2 (MUC3B) Core 5 (MUC13) Core 2 (MUC3A) glc-fuc-ADAMTS10 Sialyl-2,3 T-antigen (MUC5AC) Core 8 (MUC13) Core 7 (MUC6) B3GNT3 Core 2a (MUC5B) O-fuc-ADAMTS9 Sialyl-2,3 T-antigen (MUC19) ADAMTS19 Sialyl T-antigen (MUC19) Core 2a (MUC12) Core 5 (MUC5AC) ADAMTS16 O-fuc-ADAMTS19 Core 2 (MUC19) Core 6 (MUC12) Core 4 (MUC1) Core 2a (MUC15) ADAMTSL4 GalNAc-MUC1(24-1255) CMP-Neu5AcO-fuc-proteinsSialyl Tn antigen (MUC19) O-fuc-SEMA5B(27-1093) GalNAc-MUC2 GALNT9 Sialyl T-antigen (MUCL1) Core 2 (MUC20) Core 2a mucinsCore 4 (MUC3A) glc-fuc-SBSPglcN glc-fuc-ADAMTS18 extended Core 6 (MUC12) Sialyl-2,3 T-antigen (MUC4) ST3GAL1-4MUCL1 POFUT2 substratesTHBS2 UDP-GlcNAcDisialyl T-antigen (MUC3B) Core 6 (MUC21) Sialyl T-antigen (MUC12) THSD1 Core 3 (MUC3A) UDP-GalNAcCore 5 (MUC19) Sialyl-2,3 T-antigen (MUC5B) Sialyl-2,3 T-antigen (MUC3B) CFP Core 8 (MUC12) C1GALT1C1 Core 4 (MUC3B) Sialyl-2,3 T-antigen (MUC3A) extended Core 6mucinsSialyl T-antigen (MUC16) Core 7 (MUC13) MUC7 Disialyl T-antigen (MUC4) UDPSialyl T-antigen (MUC1) O-fuc-ADAMTSL4 glc-fuc-THSD4 Sialyl T-antigen (MUC7) Core 2a (MUC13) extended Core 6 (MUC5AC) glc-fuc-ADAMTS3 Core 4 (MUC5AC) GALNT15 Core 6 (MUC6) CMP-Neu5AcMUC3B(?-901) POFUT2glc-fuc-ADAMTSL1 Sialyl Tn antigen (MUC13) extended Core 6 (MUC3B) glc-fuc-CFP glc-fuc-ADAMTS2 Core 3 (MUC16) glc-fuc-ADAMTS17 GalNAc-MUC3A glc-fuc-ADAMTS7 Core 3 (MUC1) MUC19(?-6254) O-fuc-ADAMTS4 T-antigen (MUC3A) UDP-GalNAcO-fuc-THSD1 Core 4 (MUC20) GALNT14 ST6GALNAC2B3GNT7 SSPO ST3GAL2 O-fuc-ADAMTS6 Core 8 (MUC3A) Core 8 (MUCL1) O-fuc-SPON2 MUC21 entended Core 6 (MUC13) Core 2 (MUC13) Core 3 (MUC6) Core 7 (MUC17) Sialyl Tn antigen (MUC17) Core 7 (MUC5AC) Core 7 (MUC20) O-fuc-ADAMTS17 Sialyl-2,3 T-antigen (MUC20) glc-fuc-SPON1 SPON2 glc-fuc-ADAMTS12 Sialyl Tn antigen (MUC2) Core 4 (MUC6) Core 3 (MUC13) MUC15 MUC2 Core 7 (MUC5B) glc-fuc-ADAMTS15 Sialyl-2,3 T-antigen (MUC13) Sialyl T-antigen (MUC17) Core 6 (MUC15) C1GALT1:C1GALT1C1T-antigen (MUC5B) GalNAc-MUC17 GALNT1(1-559) extended Core 6 (MUC7) glc-fuc-ADAMTS1 Disialyl T-antigen (MUC3A) Core 2a (MUC17) O-fuc-ADAMTS15 Core 8 (MUC19) ST6GALNAC4 Disialyl T-antigen (MUC7) GCNT3B4GALT5Core 6 (MUC5AC) GALNT6 Core 6 (MUC3A) SPON1 O-fuc-ADAMTS13 glc-fuc-ADAMTS4 O-fuc-SPON1 Disialyl T-antigen (MUC13) O-fuc-THBS2 Core 4 (MUC7) UDPCore 2 (MUC17) ADAMTSL3 Core 8 (MUC1) Core 2a (MUC5AC)


Description

O-glycosylation is an important post-translational modification (PTM) required for correct functioning of many proteins (Van den Steen et al. 1998, Moremen et al. 2012). The O-glycosylation of proteins containing thrombospondin type 1 repeat (TSR) domains and O-glycosylation of mucins are currently described here. View original pathway at:Reactome.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
114867view16:37, 25 January 2021ReactomeTeamReactome version 75
113313view11:38, 2 November 2020ReactomeTeamReactome version 74
112524view15:48, 9 October 2020ReactomeTeamReactome version 73
101436view11:31, 1 November 2018ReactomeTeamreactome version 66
100975view21:08, 31 October 2018ReactomeTeamreactome version 65
100512view19:42, 31 October 2018ReactomeTeamreactome version 64
100058view16:26, 31 October 2018ReactomeTeamreactome version 63
99610view14:59, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
93999view13:50, 16 August 2017ReactomeTeamreactome version 61
93608view11:28, 9 August 2017ReactomeTeamreactome version 61
88081view09:08, 26 July 2016RyanmillerOntology Term : 'peptide and protein metabolic process' added !
88080view09:07, 26 July 2016RyanmillerOntology Term : 'classic metabolic pathway' added !
86717view09:24, 11 July 2016ReactomeTeamreactome version 56
83262view10:34, 18 November 2015ReactomeTeamVersion54
81374view12:54, 21 August 2015ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
A4GNTProteinQ9UNA3 (Uniprot-TrEMBL)
ADAMTS1 ProteinQ9UHI8 (Uniprot-TrEMBL)
ADAMTS10 ProteinQ9H324 (Uniprot-TrEMBL)
ADAMTS12 ProteinP58397 (Uniprot-TrEMBL)
ADAMTS13 ProteinQ76LX8 (Uniprot-TrEMBL)
ADAMTS14 ProteinQ8WXS8 (Uniprot-TrEMBL)
ADAMTS15 ProteinQ8TE58 (Uniprot-TrEMBL)
ADAMTS16 ProteinQ8TE57 (Uniprot-TrEMBL)
ADAMTS17 ProteinQ8TE56 (Uniprot-TrEMBL)
ADAMTS18 ProteinQ8TE60 (Uniprot-TrEMBL)
ADAMTS19 ProteinQ8TE59 (Uniprot-TrEMBL)
ADAMTS2 ProteinO95450 (Uniprot-TrEMBL)
ADAMTS20 ProteinP59510 (Uniprot-TrEMBL)
ADAMTS3 ProteinO15072 (Uniprot-TrEMBL)
ADAMTS4 ProteinO75173 (Uniprot-TrEMBL)
ADAMTS5 ProteinQ9UNA0 (Uniprot-TrEMBL)
ADAMTS6 ProteinQ9UKP5 (Uniprot-TrEMBL)
ADAMTS7 ProteinQ9UKP4 (Uniprot-TrEMBL)
ADAMTS8 ProteinQ9UP79 (Uniprot-TrEMBL)
ADAMTS9 ProteinQ9P2N4 (Uniprot-TrEMBL)
ADAMTSL1 ProteinQ8N6G6 (Uniprot-TrEMBL)
ADAMTSL2 ProteinQ86TH1 (Uniprot-TrEMBL)
ADAMTSL3 ProteinP82987 (Uniprot-TrEMBL)
ADAMTSL4 ProteinQ6UY14 (Uniprot-TrEMBL)
ADAMTSL5 ProteinQ6ZMM2 (Uniprot-TrEMBL)
B3GALTLProteinQ6Y288 (Uniprot-TrEMBL)
B3GNT2 ProteinQ9NY97 (Uniprot-TrEMBL)
B3GNT3 ProteinQ9Y2A9 (Uniprot-TrEMBL)
B3GNT4 ProteinQ9C0J1 (Uniprot-TrEMBL)
B3GNT5 ProteinQ9BYG0 (Uniprot-TrEMBL)
B3GNT6 ProteinQ6ZMB0 (Uniprot-TrEMBL)
B3GNT7 ProteinQ8NFL0 (Uniprot-TrEMBL)
B3GNT8 ProteinQ7Z7M8 (Uniprot-TrEMBL)
B3GNT9 ProteinQ6UX72 (Uniprot-TrEMBL)
B3GNTL1 ProteinQ67FW5 (Uniprot-TrEMBL)
B3GNTsComplexR-HSA-916814 (Reactome)
B4GALT5 ProteinO43286 (Uniprot-TrEMBL)
B4GALT5ComplexR-HSA-2901790 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
B4GALT6 ProteinQ9UBX8 (Uniprot-TrEMBL)
C1GALT1 ProteinQ9NS00 (Uniprot-TrEMBL)
C1GALT1:C1GALT1C1ComplexR-HSA-1964504 (Reactome)
C1GALT1C1 ProteinQ96EU7 (Uniprot-TrEMBL)
CFP ProteinP27918 (Uniprot-TrEMBL)
CMP-Neu5AcMetaboliteCHEBI:16556 (ChEBI)
CMPMetaboliteCHEBI:17361 (ChEBI)
Core 1 mucinsComplexR-HSA-1462240 (Reactome)
Core 2 (MUC1) ProteinP15941 (Uniprot-TrEMBL)
Core 2 (MUC12) ProteinQ9UKN1 (Uniprot-TrEMBL)
Core 2 (MUC13) ProteinQ9H3R2 (Uniprot-TrEMBL)
Core 2 (MUC15) ProteinQ8N387 (Uniprot-TrEMBL)
Core 2 (MUC16) ProteinQ8WXI7 (Uniprot-TrEMBL)
Core 2 (MUC17) ProteinQ685J3 (Uniprot-TrEMBL)
Core 2 (MUC19) ProteinQ7Z5P9 (Uniprot-TrEMBL)
Core 2 (MUC2) ProteinQ02817 (Uniprot-TrEMBL)
Core 2 (MUC20) ProteinQ8N307 (Uniprot-TrEMBL)
Core 2 (MUC21) ProteinQ5SSG8 (Uniprot-TrEMBL)
Core 2 (MUC3A) ProteinQ02505 (Uniprot-TrEMBL)
Core 2 (MUC3B) ProteinQ9H195 (Uniprot-TrEMBL)
Core 2 (MUC4) ProteinQ99102 (Uniprot-TrEMBL)
Core 2 (MUC5AC) ProteinP98088 (Uniprot-TrEMBL)
Core 2 (MUC5B) ProteinQ9HC84 (Uniprot-TrEMBL)
Core 2 (MUC6) ProteinQ6W4X9 (Uniprot-TrEMBL)
Core 2 (MUC7) ProteinQ8TAX7 (Uniprot-TrEMBL)
Core 2 (MUCL1) ProteinQ96DR8 (Uniprot-TrEMBL)
Core 2 mucinsComplexR-HSA-1462066 (Reactome)
Core 2a (MUC1) ProteinP15941 (Uniprot-TrEMBL)
Core 2a (MUC12) ProteinQ9UKN1 (Uniprot-TrEMBL)
Core 2a (MUC13) ProteinQ9H3R2 (Uniprot-TrEMBL)
Core 2a (MUC15) ProteinQ8N387 (Uniprot-TrEMBL)
Core 2a (MUC16) ProteinQ8WXI7 (Uniprot-TrEMBL)
Core 2a (MUC17) ProteinQ685J3 (Uniprot-TrEMBL)
Core 2a (MUC19) ProteinQ7Z5P9 (Uniprot-TrEMBL)
Core 2a (MUC2) ProteinQ02817 (Uniprot-TrEMBL)
Core 2a (MUC20) ProteinQ8N307 (Uniprot-TrEMBL)
Core 2a (MUC21) ProteinQ5SSG8 (Uniprot-TrEMBL)
Core 2a (MUC3A) ProteinQ02505 (Uniprot-TrEMBL)
Core 2a (MUC3B) ProteinQ9H195 (Uniprot-TrEMBL)
Core 2a (MUC4) ProteinQ99102 (Uniprot-TrEMBL)
Core 2a (MUC5AC) ProteinP98088 (Uniprot-TrEMBL)
Core 2a (MUC5B) ProteinQ9HC84 (Uniprot-TrEMBL)
Core 2a (MUC6) ProteinQ6W4X9 (Uniprot-TrEMBL)
Core 2a (MUC7) ProteinQ8TAX7 (Uniprot-TrEMBL)
Core 2a (MUCL1) ProteinQ96DR8 (Uniprot-TrEMBL)
Core 2a mucinsComplexR-HSA-6784268 (Reactome)
Core 3 (MUC1) ProteinP15941 (Uniprot-TrEMBL)
Core 3 (MUC12) ProteinQ9UKN1 (Uniprot-TrEMBL)
Core 3 (MUC13) ProteinQ9H3R2 (Uniprot-TrEMBL)
Core 3 (MUC15) ProteinQ8N387 (Uniprot-TrEMBL)
Core 3 (MUC16) ProteinQ8WXI7 (Uniprot-TrEMBL)
Core 3 (MUC17) ProteinQ685J3 (Uniprot-TrEMBL)
Core 3 (MUC19) ProteinQ7Z5P9 (Uniprot-TrEMBL)
Core 3 (MUC2) ProteinQ02817 (Uniprot-TrEMBL)
Core 3 (MUC20) ProteinQ8N307 (Uniprot-TrEMBL)
Core 3 (MUC21) ProteinQ5SSG8 (Uniprot-TrEMBL)
Core 3 (MUC3A) ProteinQ02505 (Uniprot-TrEMBL)
Core 3 (MUC3B) ProteinQ9H195 (Uniprot-TrEMBL)
Core 3 (MUC4) ProteinQ99102 (Uniprot-TrEMBL)
Core 3 (MUC5AC) ProteinP98088 (Uniprot-TrEMBL)
Core 3 (MUC5B) ProteinQ9HC84 (Uniprot-TrEMBL)
Core 3 (MUC6) ProteinQ6W4X9 (Uniprot-TrEMBL)
Core 3 (MUC7) ProteinQ8TAX7 (Uniprot-TrEMBL)
Core 3 (MUCL1) ProteinQ96DR8 (Uniprot-TrEMBL)
Core 3 mucinsComplexR-HSA-1462159 (Reactome)
Core 4 (MUC1) ProteinP15941 (Uniprot-TrEMBL)
Core 4 (MUC12) ProteinQ9UKN1 (Uniprot-TrEMBL)
Core 4 (MUC13) ProteinQ9H3R2 (Uniprot-TrEMBL)
Core 4 (MUC15) ProteinQ8N387 (Uniprot-TrEMBL)
Core 4 (MUC16) ProteinQ8WXI7 (Uniprot-TrEMBL)
Core 4 (MUC17) ProteinQ685J3 (Uniprot-TrEMBL)
Core 4 (MUC19) ProteinQ7Z5P9 (Uniprot-TrEMBL)
Core 4 (MUC2) ProteinQ02817 (Uniprot-TrEMBL)
Core 4 (MUC20) ProteinQ8N307 (Uniprot-TrEMBL)
Core 4 (MUC21) ProteinQ5SSG8 (Uniprot-TrEMBL)
Core 4 (MUC3A) ProteinQ02505 (Uniprot-TrEMBL)
Core 4 (MUC3B) ProteinQ9H195 (Uniprot-TrEMBL)
Core 4 (MUC4) ProteinQ99102 (Uniprot-TrEMBL)
Core 4 (MUC5AC) ProteinP98088 (Uniprot-TrEMBL)
Core 4 (MUC5B) ProteinQ9HC84 (Uniprot-TrEMBL)
Core 4 (MUC6) ProteinQ6W4X9 (Uniprot-TrEMBL)
Core 4 (MUC7) ProteinQ8TAX7 (Uniprot-TrEMBL)
Core 4 (MUCL1) ProteinQ96DR8 (Uniprot-TrEMBL)
Core 4 mucinsComplexR-HSA-1462144 (Reactome)
Core 5 (MUC1) ProteinP15941 (Uniprot-TrEMBL)
Core 5 (MUC12) ProteinQ9UKN1 (Uniprot-TrEMBL)
Core 5 (MUC13) ProteinQ9H3R2 (Uniprot-TrEMBL)
Core 5 (MUC15) ProteinQ8N387 (Uniprot-TrEMBL)
Core 5 (MUC16) ProteinQ8WXI7 (Uniprot-TrEMBL)
Core 5 (MUC17) ProteinQ685J3 (Uniprot-TrEMBL)
Core 5 (MUC19) ProteinQ7Z5P9 (Uniprot-TrEMBL)
Core 5 (MUC2) ProteinQ02817 (Uniprot-TrEMBL)
Core 5 (MUC20) ProteinQ8N307 (Uniprot-TrEMBL)
Core 5 (MUC21) ProteinQ5SSG8 (Uniprot-TrEMBL)
Core 5 (MUC3A) ProteinQ02505 (Uniprot-TrEMBL)
Core 5 (MUC3B) ProteinQ9H195 (Uniprot-TrEMBL)
Core 5 (MUC4) ProteinQ99102 (Uniprot-TrEMBL)
Core 5 (MUC5AC) ProteinP98088 (Uniprot-TrEMBL)
Core 5 (MUC5B) ProteinQ9HC84 (Uniprot-TrEMBL)
Core 5 (MUC6) ProteinQ6W4X9 (Uniprot-TrEMBL)
Core 5 (MUC7) ProteinQ8TAX7 (Uniprot-TrEMBL)
Core 5 (MUCL1) ProteinQ96DR8 (Uniprot-TrEMBL)
Core 5 mucinsComplexR-HSA-1462179 (Reactome)
Core 6 (MUC1) ProteinP15941 (Uniprot-TrEMBL)
Core 6 (MUC12) ProteinQ9UKN1 (Uniprot-TrEMBL)
Core 6 (MUC13) ProteinQ9H3R2 (Uniprot-TrEMBL)
Core 6 (MUC15) ProteinQ8N387 (Uniprot-TrEMBL)
Core 6 (MUC16) ProteinQ8WXI7 (Uniprot-TrEMBL)
Core 6 (MUC17) ProteinQ685J3 (Uniprot-TrEMBL)
Core 6 (MUC19) ProteinQ7Z5P9 (Uniprot-TrEMBL)
Core 6 (MUC2) ProteinQ02817 (Uniprot-TrEMBL)
Core 6 (MUC20) ProteinQ8N307 (Uniprot-TrEMBL)
Core 6 (MUC21) ProteinQ5SSG8 (Uniprot-TrEMBL)
Core 6 (MUC3A) ProteinQ02505 (Uniprot-TrEMBL)
Core 6 (MUC3B) ProteinQ9H195 (Uniprot-TrEMBL)
Core 6 (MUC4) ProteinQ99102 (Uniprot-TrEMBL)
Core 6 (MUC5AC) ProteinP98088 (Uniprot-TrEMBL)
Core 6 (MUC5B) ProteinQ9HC84 (Uniprot-TrEMBL)
Core 6 (MUC6) ProteinQ6W4X9 (Uniprot-TrEMBL)
Core 6 (MUC7) ProteinQ8TAX7 (Uniprot-TrEMBL)
Core 6 (MUCL1) ProteinQ96DR8 (Uniprot-TrEMBL)
Core 6 mucinsComplexR-HSA-1462353 (Reactome)
Core 7 (MUC1) ProteinP15941 (Uniprot-TrEMBL)
Core 7 (MUC12) ProteinQ9UKN1 (Uniprot-TrEMBL)
Core 7 (MUC13) ProteinQ9H3R2 (Uniprot-TrEMBL)
Core 7 (MUC15) ProteinQ8N387 (Uniprot-TrEMBL)
Core 7 (MUC16) ProteinQ8WXI7 (Uniprot-TrEMBL)
Core 7 (MUC17) ProteinQ685J3 (Uniprot-TrEMBL)
Core 7 (MUC19) ProteinQ7Z5P9 (Uniprot-TrEMBL)
Core 7 (MUC2) ProteinQ02817 (Uniprot-TrEMBL)
Core 7 (MUC20) ProteinQ8N307 (Uniprot-TrEMBL)
Core 7 (MUC21) ProteinQ5SSG8 (Uniprot-TrEMBL)
Core 7 (MUC3A) ProteinQ02505 (Uniprot-TrEMBL)
Core 7 (MUC3B) ProteinQ9H195 (Uniprot-TrEMBL)
Core 7 (MUC4) ProteinQ99102 (Uniprot-TrEMBL)
Core 7 (MUC5AC) ProteinP98088 (Uniprot-TrEMBL)
Core 7 (MUC5B) ProteinQ9HC84 (Uniprot-TrEMBL)
Core 7 (MUC6) ProteinQ6W4X9 (Uniprot-TrEMBL)
Core 7 (MUC7) ProteinQ8TAX7 (Uniprot-TrEMBL)
Core 7 (MUCL1) ProteinQ96DR8 (Uniprot-TrEMBL)
Core 7 mucinsComplexR-HSA-1462341 (Reactome)
Core 8 (MUC1) ProteinP15941 (Uniprot-TrEMBL)
Core 8 (MUC12) ProteinQ9UKN1 (Uniprot-TrEMBL)
Core 8 (MUC13) ProteinQ9H3R2 (Uniprot-TrEMBL)
Core 8 (MUC15) ProteinQ8N387 (Uniprot-TrEMBL)
Core 8 (MUC16) ProteinQ8WXI7 (Uniprot-TrEMBL)
Core 8 (MUC17) ProteinQ685J3 (Uniprot-TrEMBL)
Core 8 (MUC19) ProteinQ7Z5P9 (Uniprot-TrEMBL)
Core 8 (MUC2) ProteinQ02817 (Uniprot-TrEMBL)
Core 8 (MUC20) ProteinQ8N307 (Uniprot-TrEMBL)
Core 8 (MUC21) ProteinQ5SSG8 (Uniprot-TrEMBL)
Core 8 (MUC3A) ProteinQ02505 (Uniprot-TrEMBL)
Core 8 (MUC3B) ProteinQ9H195 (Uniprot-TrEMBL)
Core 8 (MUC4) ProteinQ99102 (Uniprot-TrEMBL)
Core 8 (MUC5AC) ProteinP98088 (Uniprot-TrEMBL)
Core 8 (MUC5B) ProteinQ9HC84 (Uniprot-TrEMBL)
Core 8 (MUC6) ProteinQ6W4X9 (Uniprot-TrEMBL)
Core 8 (MUC7) ProteinQ8TAX7 (Uniprot-TrEMBL)
Core 8 (MUCL1) ProteinQ96DR8 (Uniprot-TrEMBL)
Core 8 mucinsComplexR-HSA-1462115 (Reactome)
Disialyl T antigensComplexR-HSA-1463507 (Reactome)
Disialyl T-antigen (MUC1) ProteinP15941 (Uniprot-TrEMBL)
Disialyl T-antigen (MUC12) ProteinQ9UKN1 (Uniprot-TrEMBL)
Disialyl T-antigen (MUC13) ProteinQ9H3R2 (Uniprot-TrEMBL)
Disialyl T-antigen (MUC15) ProteinQ8N387 (Uniprot-TrEMBL)
Disialyl T-antigen (MUC16) ProteinQ8WXI7 (Uniprot-TrEMBL)
Disialyl T-antigen (MUC17) ProteinQ685J3 (Uniprot-TrEMBL)
Disialyl T-antigen (MUC19) ProteinQ7Z5P9 (Uniprot-TrEMBL)
Disialyl T-antigen (MUC2) ProteinQ02817 (Uniprot-TrEMBL)
Disialyl T-antigen (MUC20) ProteinQ8N307 (Uniprot-TrEMBL)
Disialyl T-antigen (MUC21) ProteinQ5SSG8 (Uniprot-TrEMBL)
Disialyl T-antigen (MUC3A) ProteinQ02505 (Uniprot-TrEMBL)
Disialyl T-antigen (MUC3B) ProteinQ9H195 (Uniprot-TrEMBL)
Disialyl T-antigen (MUC4) ProteinQ99102 (Uniprot-TrEMBL)
Disialyl T-antigen (MUC5AC) ProteinP98088 (Uniprot-TrEMBL)
Disialyl T-antigen (MUC5B) ProteinQ9HC84 (Uniprot-TrEMBL)
Disialyl T-antigen (MUC6) ProteinQ6W4X9 (Uniprot-TrEMBL)
Disialyl T-antigen (MUC7) ProteinQ8TAX7 (Uniprot-TrEMBL)
Disialyl T-antigen (MUCL1) ProteinQ96DR8 (Uniprot-TrEMBL)
GALNT1(1-559) ProteinQ10472 (Uniprot-TrEMBL)
GALNT10 ProteinQ86SR1 (Uniprot-TrEMBL)
GALNT11 ProteinQ8NCW6 (Uniprot-TrEMBL)
GALNT12 ProteinQ8IXK2 (Uniprot-TrEMBL)
GALNT13 ProteinQ8IUC8 (Uniprot-TrEMBL)
GALNT14 ProteinQ96FL9 (Uniprot-TrEMBL)
GALNT15 ProteinQ8N3T1 (Uniprot-TrEMBL)
GALNT16 ProteinQ8N428 (Uniprot-TrEMBL)
GALNT18 ProteinQ6P9A2 (Uniprot-TrEMBL)
GALNT2(1-571) ProteinQ10471 (Uniprot-TrEMBL)
GALNT3 ProteinQ14435 (Uniprot-TrEMBL)
GALNT4 ProteinQ8N4A0 (Uniprot-TrEMBL)
GALNT5 ProteinQ7Z7M9 (Uniprot-TrEMBL)
GALNT6 ProteinQ8NCL4 (Uniprot-TrEMBL)
GALNT7 ProteinQ86SF2 (Uniprot-TrEMBL)
GALNT8 ProteinQ9NY28 (Uniprot-TrEMBL)
GALNT9 ProteinQ9HCQ5 (Uniprot-TrEMBL)
GALNT:C1GALT1C1ComplexR-HSA-914019 (Reactome)
GALNTL5 ProteinQ7Z4T8 (Uniprot-TrEMBL)
GALNTL6 ProteinQ49A17 (Uniprot-TrEMBL)
GCNT1 ProteinQ02742 (Uniprot-TrEMBL)
GCNT3 ProteinO95395 (Uniprot-TrEMBL)
GCNT3ProteinO95395 (Uniprot-TrEMBL)
GCNT4 ProteinQ9P109 (Uniprot-TrEMBL)
GCNT6 ProteinQ5T4J0 (Uniprot-TrEMBL)
GCNT7 ProteinQ6ZNI0 (Uniprot-TrEMBL)
GCNTsComplexR-HSA-914009 (Reactome)
GalNAc-MUC1(24-1255) ProteinP15941 (Uniprot-TrEMBL)
GalNAc-MUC12 ProteinQ9UKN1 (Uniprot-TrEMBL)
GalNAc-MUC13 ProteinQ9H3R2 (Uniprot-TrEMBL)
GalNAc-MUC15 ProteinQ8N387 (Uniprot-TrEMBL)
GalNAc-MUC16 ProteinQ8WXI7 (Uniprot-TrEMBL)
GalNAc-MUC17 ProteinQ685J3 (Uniprot-TrEMBL)
GalNAc-MUC19(?-6254) ProteinQ7Z5P9 (Uniprot-TrEMBL)
GalNAc-MUC2 ProteinQ02817 (Uniprot-TrEMBL)
GalNAc-MUC20 ProteinQ8N307 (Uniprot-TrEMBL)
GalNAc-MUC21 ProteinQ5SSG8 (Uniprot-TrEMBL)
GalNAc-MUC3A ProteinQ02505 (Uniprot-TrEMBL)
GalNAc-MUC3B(?-901) ProteinQ9H195 (Uniprot-TrEMBL)
GalNAc-MUC4(29-2169) ProteinQ99102 (Uniprot-TrEMBL)
GalNAc-MUC5AC ProteinP98088 (Uniprot-TrEMBL)
GalNAc-MUC5B(26-5703) ProteinQ9HC84 (Uniprot-TrEMBL)
GalNAc-MUC6(23-2392) ProteinQ6W4X9 (Uniprot-TrEMBL)
GalNAc-MUC7 ProteinQ8TAX7 (Uniprot-TrEMBL)
GalNAc-MUCL1 ProteinQ96DR8 (Uniprot-TrEMBL)
MUC1(24-1255) ProteinP15941 (Uniprot-TrEMBL)
MUC12 ProteinQ9UKN1 (Uniprot-TrEMBL)
MUC13 ProteinQ9H3R2 (Uniprot-TrEMBL)
MUC15 ProteinQ8N387 (Uniprot-TrEMBL)
MUC16 ProteinQ8WXI7 (Uniprot-TrEMBL)
MUC17 ProteinQ685J3 (Uniprot-TrEMBL)
MUC19(?-6254) ProteinQ7Z5P9 (Uniprot-TrEMBL)
MUC2 ProteinQ02817 (Uniprot-TrEMBL)
MUC20 ProteinQ8N307 (Uniprot-TrEMBL)
MUC21 ProteinQ5SSG8 (Uniprot-TrEMBL)
MUC3A ProteinQ02505 (Uniprot-TrEMBL)
MUC3B(?-901) ProteinQ9H195 (Uniprot-TrEMBL)
MUC4(29-2169) ProteinQ99102 (Uniprot-TrEMBL)
MUC5AC ProteinP98088 (Uniprot-TrEMBL)
MUC5B(26-5703) ProteinQ9HC84 (Uniprot-TrEMBL)
MUC6(23-2392) ProteinQ6W4X9 (Uniprot-TrEMBL)
MUC7 ProteinQ8TAX7 (Uniprot-TrEMBL)
MUCL1 ProteinQ96DR8 (Uniprot-TrEMBL)
MucinsComplexR-HSA-913666 (Reactome)
O-fuc-ADAMTS1 ProteinQ9UHI8 (Uniprot-TrEMBL)
O-fuc-ADAMTS10 ProteinQ9H324 (Uniprot-TrEMBL)
O-fuc-ADAMTS12 ProteinP58397 (Uniprot-TrEMBL)
O-fuc-ADAMTS13 ProteinQ76LX8 (Uniprot-TrEMBL)
O-fuc-ADAMTS14 ProteinQ8WXS8 (Uniprot-TrEMBL)
O-fuc-ADAMTS15 ProteinQ8TE58 (Uniprot-TrEMBL)
O-fuc-ADAMTS16 ProteinQ8TE57 (Uniprot-TrEMBL)
O-fuc-ADAMTS17 ProteinQ8TE56 (Uniprot-TrEMBL)
O-fuc-ADAMTS18 ProteinQ8TE60 (Uniprot-TrEMBL)
O-fuc-ADAMTS19 ProteinQ8TE59 (Uniprot-TrEMBL)
O-fuc-ADAMTS2 ProteinO95450 (Uniprot-TrEMBL)
O-fuc-ADAMTS20 ProteinP59510 (Uniprot-TrEMBL)
O-fuc-ADAMTS3 ProteinO15072 (Uniprot-TrEMBL)
O-fuc-ADAMTS4 ProteinO75173 (Uniprot-TrEMBL)
O-fuc-ADAMTS5 ProteinQ9UNA0 (Uniprot-TrEMBL)
O-fuc-ADAMTS6 ProteinQ9UKP5 (Uniprot-TrEMBL)
O-fuc-ADAMTS7 ProteinQ9UKP4 (Uniprot-TrEMBL)
O-fuc-ADAMTS8 ProteinQ9UP79 (Uniprot-TrEMBL)
O-fuc-ADAMTS9 ProteinQ9P2N4 (Uniprot-TrEMBL)
O-fuc-ADAMTSL1 ProteinQ8N6G6 (Uniprot-TrEMBL)
O-fuc-ADAMTSL2 ProteinQ86TH1 (Uniprot-TrEMBL)
O-fuc-ADAMTSL3 ProteinP82987 (Uniprot-TrEMBL)
O-fuc-ADAMTSL4 ProteinQ6UY14 (Uniprot-TrEMBL)
O-fuc-ADAMTSL5 ProteinQ6ZMM2 (Uniprot-TrEMBL)
O-fuc-CFP ProteinP27918 (Uniprot-TrEMBL)
O-fuc-SBSPON ProteinQ8IVN8 (Uniprot-TrEMBL)
O-fuc-SEMA5A ProteinQ13591 (Uniprot-TrEMBL)
O-fuc-SEMA5B(27-1093) ProteinQ9P283 (Uniprot-TrEMBL)
O-fuc-SPON1 ProteinQ9HCB6 (Uniprot-TrEMBL)
O-fuc-SPON2 ProteinQ9BUD6 (Uniprot-TrEMBL)
O-fuc-SSPO ProteinA2VEC9 (Uniprot-TrEMBL)
O-fuc-THBS1 ProteinP07996 (Uniprot-TrEMBL)
O-fuc-THBS2 ProteinP35442 (Uniprot-TrEMBL)
O-fuc-THSD1 ProteinQ9NS62 (Uniprot-TrEMBL)
O-fuc-THSD4 ProteinQ6ZMP0 (Uniprot-TrEMBL)
O-fuc-THSD7A ProteinQ9UPZ6 (Uniprot-TrEMBL)
O-fuc-THSD7B ProteinQ9C0I4 (Uniprot-TrEMBL)
O-fuc-proteinsComplexR-HSA-5173164 (Reactome)
POFUT2 substratesComplexR-HSA-5173014 (Reactome)
POFUT2ProteinQ9Y2G5 (Uniprot-TrEMBL)
SBSPON ProteinQ8IVN8 (Uniprot-TrEMBL)
SEMA5A ProteinQ13591 (Uniprot-TrEMBL)
SEMA5B(27-1093) ProteinQ9P283 (Uniprot-TrEMBL)
SPON1 ProteinQ9HCB6 (Uniprot-TrEMBL)
SPON2 ProteinQ9BUD6 (Uniprot-TrEMBL)
SSPO ProteinA2VEC9 (Uniprot-TrEMBL)
ST3GAL1 ProteinQ11201 (Uniprot-TrEMBL)
ST3GAL1-4ComplexR-HSA-981491 (Reactome)
ST3GAL2 ProteinQ16842 (Uniprot-TrEMBL)
ST3GAL3 ProteinQ11203 (Uniprot-TrEMBL)
ST3GAL4 ProteinQ11206 (Uniprot-TrEMBL)
ST6GAL1ProteinP15907 (Uniprot-TrEMBL)
ST6GALNAC2ProteinQ9UJ37 (Uniprot-TrEMBL)
ST6GALNAC3 ProteinQ8NDV1 (Uniprot-TrEMBL)
ST6GALNAC3/4ComplexR-HSA-981824 (Reactome)
ST6GALNAC4 ProteinQ9H4F1 (Uniprot-TrEMBL)
Sialyl Tn antigen (MUCL1) ProteinQ96DR8 (Uniprot-TrEMBL)
Sialyl T-antigen (MUC1) ProteinP15941 (Uniprot-TrEMBL)
Sialyl T-antigen (MUC12) ProteinQ9UKN1 (Uniprot-TrEMBL)
Sialyl T-antigen (MUC13) ProteinQ9H3R2 (Uniprot-TrEMBL)
Sialyl T-antigen (MUC15) ProteinQ8N387 (Uniprot-TrEMBL)
Sialyl T-antigen (MUC16) ProteinQ8WXI7 (Uniprot-TrEMBL)
Sialyl T-antigen (MUC17) ProteinQ685J3 (Uniprot-TrEMBL)
Sialyl T-antigen (MUC19) ProteinQ7Z5P9 (Uniprot-TrEMBL)
Sialyl T-antigen (MUC2) ProteinQ02817 (Uniprot-TrEMBL)
Sialyl T-antigen (MUC20) ProteinQ8N307 (Uniprot-TrEMBL)
Sialyl T-antigen (MUC21) ProteinQ5SSG8 (Uniprot-TrEMBL)
Sialyl T-antigen (MUC3A) ProteinQ02505 (Uniprot-TrEMBL)
Sialyl T-antigen (MUC3B) ProteinQ9H195 (Uniprot-TrEMBL)
Sialyl T-antigen (MUC4) ProteinQ99102 (Uniprot-TrEMBL)
Sialyl T-antigen (MUC5AC) ProteinP98088 (Uniprot-TrEMBL)
Sialyl T-antigen (MUC5B) ProteinQ9HC84 (Uniprot-TrEMBL)
Sialyl T-antigen (MUC6) ProteinQ6W4X9 (Uniprot-TrEMBL)
Sialyl T-antigen (MUC7) ProteinQ8TAX7 (Uniprot-TrEMBL)
Sialyl T-antigen (MUCL1) ProteinQ96DR8 (Uniprot-TrEMBL)
Sialyl Tn antigen (MUC1) ProteinP15941 (Uniprot-TrEMBL)
Sialyl Tn antigen (MUC12) ProteinQ9UKN1 (Uniprot-TrEMBL)
Sialyl Tn antigen (MUC13) ProteinQ9H3R2 (Uniprot-TrEMBL)
Sialyl Tn antigen (MUC15) ProteinQ8N387 (Uniprot-TrEMBL)
Sialyl Tn antigen (MUC16) ProteinQ8WXI7 (Uniprot-TrEMBL)
Sialyl Tn antigen (MUC17) ProteinQ685J3 (Uniprot-TrEMBL)
Sialyl Tn antigen (MUC19) ProteinQ7Z5P9 (Uniprot-TrEMBL)
Sialyl Tn antigen (MUC2) ProteinQ02817 (Uniprot-TrEMBL)
Sialyl Tn antigen (MUC20) ProteinQ8N307 (Uniprot-TrEMBL)
Sialyl Tn antigen (MUC21) ProteinQ5SSG8 (Uniprot-TrEMBL)
Sialyl Tn antigen (MUC3A) ProteinQ02505 (Uniprot-TrEMBL)
Sialyl Tn antigen (MUC3B) ProteinQ9H195 (Uniprot-TrEMBL)
Sialyl Tn antigen (MUC4) ProteinQ99102 (Uniprot-TrEMBL)
Sialyl Tn antigen (MUC5AC) ProteinP98088 (Uniprot-TrEMBL)
Sialyl Tn antigen (MUC5B) ProteinQ9HC84 (Uniprot-TrEMBL)
Sialyl Tn antigen (MUC6) ProteinQ6W4X9 (Uniprot-TrEMBL)
Sialyl Tn antigen (MUC7) ProteinQ8TAX7 (Uniprot-TrEMBL)
Sialyl Tn antigensComplexR-HSA-1463504 (Reactome)
Sialyl-2,3 T antigensComplexR-HSA-1463569 (Reactome)
Sialyl-2,3 T-antigen (MUC1) ProteinP15941 (Uniprot-TrEMBL)
Sialyl-2,3 T-antigen (MUC12) ProteinQ9UKN1 (Uniprot-TrEMBL)
Sialyl-2,3 T-antigen (MUC13) ProteinQ9H3R2 (Uniprot-TrEMBL)
Sialyl-2,3 T-antigen (MUC15) ProteinQ8N387 (Uniprot-TrEMBL)
Sialyl-2,3 T-antigen (MUC16) ProteinQ8WXI7 (Uniprot-TrEMBL)
Sialyl-2,3 T-antigen (MUC17) ProteinQ685J3 (Uniprot-TrEMBL)
Sialyl-2,3 T-antigen (MUC19) ProteinQ7Z5P9 (Uniprot-TrEMBL)
Sialyl-2,3 T-antigen (MUC2) ProteinQ02817 (Uniprot-TrEMBL)
Sialyl-2,3 T-antigen (MUC20) ProteinQ8N307 (Uniprot-TrEMBL)
Sialyl-2,3 T-antigen (MUC21) ProteinQ5SSG8 (Uniprot-TrEMBL)
Sialyl-2,3 T-antigen (MUC3A) ProteinQ02505 (Uniprot-TrEMBL)
Sialyl-2,3 T-antigen (MUC3B) ProteinQ9H195 (Uniprot-TrEMBL)
Sialyl-2,3 T-antigen (MUC4) ProteinQ99102 (Uniprot-TrEMBL)
Sialyl-2,3 T-antigen (MUC5AC) ProteinP98088 (Uniprot-TrEMBL)
Sialyl-2,3 T-antigen (MUC5B) ProteinQ9HC84 (Uniprot-TrEMBL)
Sialyl-2,3 T-antigen (MUC6) ProteinQ6W4X9 (Uniprot-TrEMBL)
Sialyl-2,3 T-antigen (MUC7) ProteinQ8TAX7 (Uniprot-TrEMBL)
Sialyl-2,3 T-antigen (MUCL1) ProteinQ96DR8 (Uniprot-TrEMBL)
Sialyl-2,6 T antigensComplexR-HSA-1463568 (Reactome)
T-antigen (MUC1) ProteinP15941 (Uniprot-TrEMBL)
T-antigen (MUC12) ProteinQ9UKN1 (Uniprot-TrEMBL)
T-antigen (MUC13) ProteinQ9H3R2 (Uniprot-TrEMBL)
T-antigen (MUC15) ProteinQ8N387 (Uniprot-TrEMBL)
T-antigen (MUC16) ProteinQ8WXI7 (Uniprot-TrEMBL)
T-antigen (MUC17) ProteinQ685J3 (Uniprot-TrEMBL)
T-antigen (MUC19) ProteinQ7Z5P9 (Uniprot-TrEMBL)
T-antigen (MUC2) ProteinQ02817 (Uniprot-TrEMBL)
T-antigen (MUC20) ProteinQ8N307 (Uniprot-TrEMBL)
T-antigen (MUC21) ProteinQ5SSG8 (Uniprot-TrEMBL)
T-antigen (MUC3A) ProteinQ02505 (Uniprot-TrEMBL)
T-antigen (MUC3B) ProteinQ9H195 (Uniprot-TrEMBL)
T-antigen (MUC4) ProteinQ99102 (Uniprot-TrEMBL)
T-antigen (MUC5AC) ProteinP98088 (Uniprot-TrEMBL)
T-antigen (MUC5B) ProteinQ9HC84 (Uniprot-TrEMBL)
T-antigen (MUC6) ProteinQ6W4X9 (Uniprot-TrEMBL)
T-antigen (MUC7) ProteinQ8TAX7 (Uniprot-TrEMBL)
T-antigen (MUCL1) ProteinQ96DR8 (Uniprot-TrEMBL)
THBS1 ProteinP07996 (Uniprot-TrEMBL)
THBS2 ProteinP35442 (Uniprot-TrEMBL)
THSD1 ProteinQ9NS62 (Uniprot-TrEMBL)
THSD4 ProteinQ6ZMP0 (Uniprot-TrEMBL)
THSD7A ProteinQ9UPZ6 (Uniprot-TrEMBL)
THSD7B ProteinQ9C0I4 (Uniprot-TrEMBL)
Tn antigensComplexR-HSA-913659 (Reactome)
UDP-GalMetaboliteCHEBI:18307 (ChEBI)
UDP-GalNAcMetaboliteCHEBI:16650 (ChEBI)
UDP-GlcMetaboliteCHEBI:18066 (ChEBI)
UDP-GlcNAcMetaboliteCHEBI:16264 (ChEBI)
UDPMetaboliteCHEBI:17659 (ChEBI)
WBSCR17 ProteinQ6IS24 (Uniprot-TrEMBL)
entended Core 6 (MUC13) ProteinQ9H3R2 (Uniprot-TrEMBL)
extended Core 6 mucinsComplexR-HSA-1967037 (Reactome)
extended Core 6 (MUC1) ProteinP15941 (Uniprot-TrEMBL)
extended Core 6 (MUC12) ProteinQ9UKN1 (Uniprot-TrEMBL)
extended Core 6 (MUC15) ProteinQ8N387 (Uniprot-TrEMBL)
extended Core 6 (MUC16) ProteinQ8WXI7 (Uniprot-TrEMBL)
extended Core 6 (MUC17) ProteinQ685J3 (Uniprot-TrEMBL)
extended Core 6 (MUC19) ProteinQ7Z5P9 (Uniprot-TrEMBL)
extended Core 6 (MUC2) ProteinQ02817 (Uniprot-TrEMBL)
extended Core 6 (MUC20) ProteinQ8N307 (Uniprot-TrEMBL)
extended Core 6 (MUC21) ProteinQ5SSG8 (Uniprot-TrEMBL)
extended Core 6 (MUC3A) ProteinQ02505 (Uniprot-TrEMBL)
extended Core 6 (MUC3B) ProteinQ9H195 (Uniprot-TrEMBL)
extended Core 6 (MUC4) ProteinQ99102 (Uniprot-TrEMBL)
extended Core 6 (MUC5AC) ProteinP98088 (Uniprot-TrEMBL)
extended Core 6 (MUC5B) ProteinQ9HC84 (Uniprot-TrEMBL)
extended Core 6 (MUC6) ProteinQ6W4X9 (Uniprot-TrEMBL)
extended Core 6 (MUC7) ProteinQ8TAX7 (Uniprot-TrEMBL)
extended Core 6 (MUCL1) ProteinQ96DR8 (Uniprot-TrEMBL)
glc-fuc-ADAMTS1 ProteinQ9UHI8 (Uniprot-TrEMBL)
glc-fuc-ADAMTS10 ProteinQ9H324 (Uniprot-TrEMBL)
glc-fuc-ADAMTS12 ProteinP58397 (Uniprot-TrEMBL)
glc-fuc-ADAMTS13 ProteinQ76LX8 (Uniprot-TrEMBL)
glc-fuc-ADAMTS14 ProteinQ8WXS8 (Uniprot-TrEMBL)
glc-fuc-ADAMTS15 ProteinQ8TE58 (Uniprot-TrEMBL)
glc-fuc-ADAMTS16 ProteinQ8TE57 (Uniprot-TrEMBL)
glc-fuc-ADAMTS17 ProteinQ8TE56 (Uniprot-TrEMBL)
glc-fuc-ADAMTS18 ProteinQ8TE60 (Uniprot-TrEMBL)
glc-fuc-ADAMTS19 ProteinQ8TE59 (Uniprot-TrEMBL)
glc-fuc-ADAMTS2 ProteinO95450 (Uniprot-TrEMBL)
glc-fuc-ADAMTS20 ProteinP59510 (Uniprot-TrEMBL)
glc-fuc-ADAMTS3 ProteinO15072 (Uniprot-TrEMBL)
glc-fuc-ADAMTS4 ProteinO75173 (Uniprot-TrEMBL)
glc-fuc-ADAMTS5 ProteinQ9UNA0 (Uniprot-TrEMBL)
glc-fuc-ADAMTS6 ProteinQ9UKP5 (Uniprot-TrEMBL)
glc-fuc-ADAMTS7 ProteinQ9UKP4 (Uniprot-TrEMBL)
glc-fuc-ADAMTS8 ProteinQ9UP79 (Uniprot-TrEMBL)
glc-fuc-ADAMTS9 ProteinQ9P2N4 (Uniprot-TrEMBL)
glc-fuc-ADAMTSL1 ProteinQ8N6G6 (Uniprot-TrEMBL)
glc-fuc-ADAMTSL2 ProteinQ86TH1 (Uniprot-TrEMBL)
glc-fuc-ADAMTSL3 ProteinP82987 (Uniprot-TrEMBL)
glc-fuc-ADAMTSL4 ProteinQ6UY14 (Uniprot-TrEMBL)
glc-fuc-ADAMTSL5 ProteinQ6ZMM2 (Uniprot-TrEMBL)
glc-fuc-CFP ProteinP27918 (Uniprot-TrEMBL)
glc-fuc-SBSPglcN ProteinQ8IVN8 (Uniprot-TrEMBL)
glc-fuc-SEMA5A ProteinQ13591 (Uniprot-TrEMBL)
glc-fuc-SEMA5B(27-1093) ProteinQ9P283 (Uniprot-TrEMBL)
glc-fuc-SPON1 ProteinQ9HCB6 (Uniprot-TrEMBL)
glc-fuc-SPON2 ProteinQ9BUD6 (Uniprot-TrEMBL)
glc-fuc-SSPPO ProteinA2VEC9 (Uniprot-TrEMBL)
glc-fuc-THBS1 ProteinP07996 (Uniprot-TrEMBL)
glc-fuc-THBS2 ProteinP35442 (Uniprot-TrEMBL)
glc-fuc-THSD1 ProteinQ9NS62 (Uniprot-TrEMBL)
glc-fuc-THSD4 ProteinQ6ZMP0 (Uniprot-TrEMBL)
glc-fuc-THSD7A ProteinQ9UPZ6 (Uniprot-TrEMBL)
glc-fuc-THSD7B ProteinQ9C0I4 (Uniprot-TrEMBL)
glc-fuc-proteinsComplexR-HSA-5173276 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
A4GNTmim-catalysisR-HSA-5694487 (Reactome)
B3GALTLmim-catalysisR-HSA-5173005 (Reactome)
B3GNTsmim-catalysisR-HSA-914010 (Reactome)
B4GALT5mim-catalysisR-HSA-1964501 (Reactome)
C1GALT1:C1GALT1C1mim-catalysisR-HSA-1964505 (Reactome)
CMP-Neu5AcR-HSA-977071 (Reactome)
CMP-Neu5AcR-HSA-977228 (Reactome)
CMP-Neu5AcR-HSA-981497 (Reactome)
CMP-Neu5AcR-HSA-981809 (Reactome)
CMP-Neu5AcR-HSA-981814 (Reactome)
CMPArrowR-HSA-977071 (Reactome)
CMPArrowR-HSA-977228 (Reactome)
CMPArrowR-HSA-981497 (Reactome)
CMPArrowR-HSA-981809 (Reactome)
CMPArrowR-HSA-981814 (Reactome)
Core 1 mucinsArrowR-HSA-1964505 (Reactome)
Core 1 mucinsR-HSA-914012 (Reactome)
Core 1 mucinsR-HSA-977228 (Reactome)
Core 1 mucinsR-HSA-981497 (Reactome)
Core 1 mucinsR-HSA-981814 (Reactome)
Core 2 mucinsArrowR-HSA-914012 (Reactome)
Core 2 mucinsR-HSA-5694487 (Reactome)
Core 2a mucinsArrowR-HSA-5694487 (Reactome)
Core 3 mucinsArrowR-HSA-914010 (Reactome)
Core 3 mucinsR-HSA-914018 (Reactome)
Core 4 mucinsArrowR-HSA-914018 (Reactome)
Core 5 mucinsArrowR-HSA-914005 (Reactome)
Core 6 mucinsArrowR-HSA-914008 (Reactome)
Core 6 mucinsR-HSA-1964501 (Reactome)
Core 7 mucinsArrowR-HSA-914017 (Reactome)
Core 8 mucinsArrowR-HSA-914006 (Reactome)
Disialyl T antigensArrowR-HSA-981809 (Reactome)
GALNT:C1GALT1C1mim-catalysisR-HSA-913675 (Reactome)
GCNT3mim-catalysisR-HSA-914018 (Reactome)
GCNTsmim-catalysisR-HSA-914012 (Reactome)
MucinsR-HSA-913675 (Reactome)
O-fuc-proteinsArrowR-HSA-5173192 (Reactome)
O-fuc-proteinsR-HSA-5173005 (Reactome)
POFUT2 substratesR-HSA-5173192 (Reactome)
POFUT2mim-catalysisR-HSA-5173192 (Reactome)
R-HSA-1964501 (Reactome) Beta-1,4-galactosyltransferase 5 (B4GALT5) mediates the transfer of galactose from UDP-galactose to Core 6 glycoproteins (Sato et al. 1998).
R-HSA-1964505 (Reactome) Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (C1GALT1) (Ju et al. 2002) mediates the transfer of galactose (Gal) from UDP-galactose to Tn antigens to form Core 1 mucins. C1GALT1 is active when in complex with the molecular chaperone C1GALT1C1 (aka COSMC) which assists in the folding and/or stability of C1GALT1 (Ju & Cummings 2002).
R-HSA-5173005 (Reactome) Human beta-1,3-glucosyltransferase-like protein (B3GALTL), localised on the ER membrane, glucosylates O-fucosylated proteins. The resultant glc-beta-1,3-fuc disaccharide modification on thrombospondin type 1 repeat (TSR1) domain-containing proteins is thought assist in the secretion of many of these proteins from the ER lumen. Defects in B3GALTL can cause Peters-plus syndrome (PpS; MIM:261540), an autosomal recessive disorder characterised by anterior eye chamber defects, short stature, delay in growth and mental developmental and cleft lip and/or palate. A missense mutations causing PpS is G393E (Dassie-Ajdid et al. 2009).
R-HSA-5173192 (Reactome) The O-fucosylation of proteins containing thrombospondin type 1 repeat (TSR1) domains is carried out by protein fucosyltransferase 2 (POFUT2). Only POFUT2 recognises the consensus sequence CSXS/TCG found in TSR1 domains and the fucosyl residue is attached to the hydroxyl group of conserved serine (S) or threonine (T) residues within the consensus sequence (Chen et al. 2012). The modification was first demonstrated on thrombospondin 1 (THBS1, TSP1), found in platelets and the ECM (Hofsteenge et al. 2001, Luo et al. 2006). In humans, there are more than 60 of these TSR1 domain-containing proteins. Only the proteins with similarity to experimentally confirmed ones are listed as candidates.
R-HSA-5694487 (Reactome) Alpha-1,4-N-acetylglucosaminyltransferase (A4GNT) can catalyse the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched mucins, creating an alpha1,4-linkage with beta-Gal residues (arbitrarily named Core 2a mucins) (Nakayama et al. 1999, Zhang et al. 2001).
R-HSA-913675 (Reactome) The family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases (GalNAc-transferases, GALNTs) carry out the addition of N-acetylgalactosamine on serine or threonine residues of proteins, especially mucins (Wandall et al. 1997). This reaction takes place in the Golgi apparatus (Röttger et al. 1998). There are 20 known members of the GALNT family, 15 of which have been characterised and 5 candidate members which are thought to belong to this family based on sequence similarity. The molecular chaperone C1GALT1C1-specific chaperone (COSMC) is thought to be required for N-acetylgalactosaminyltransferase activity (Yu & Cummings 2002).
R-HSA-914005 (Reactome) An unknown N-acetylglucosaminyltransferase mediates the transfer of GlcNAc to Tn antigens via an alpha-1,3 linkage to create Core 5 mucins (Brockhausen et al. 2009).
R-HSA-914006 (Reactome) An unknown galactosyltransferase mediates the transfer of galactose is transferred to Tn antigens via an alpha-1,3 linkage to create Core 8 mucins (Brockhausen et al. 2009).
R-HSA-914008 (Reactome) An unknown N-acetylglucosaminyltransferase mediates the transfer of GlcNAc to Tn antigens via an beta-1,6 linkage to create Core 6 mucins (Brockhausen et al. 2009).
R-HSA-914010 (Reactome) The UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase family (B3GNTs) consists of 9 members in humans (Kolbinger et al, 1998; Shiraishi et al, 2001; Togayachi et al, 2001; Iwai et al, 2002; Huang et al, 2004; Ishida et al, 2005; Zheng et al, 2004). They catalyse the addition of N-acetylglucosamine to the T antigen to form the Core 3 glycoprotein (Togayachi et al, 2006). Thie reaction occurs in the Golgi.
R-HSA-914012 (Reactome) The human gene GCNT encodes beta-1,6-N-acetylglucosaminyltransferase which mediates core 2 O-glycan branching by the addition of N-acetylgalactosamine, an important step in mucin-type biosynthesis. There are 3 defined members in humans, 1, 3 and 4 (Bierhuizen and Fukuda, 1992; Yeh et al, 1999; Schwientek et al, 2000). Two members (6 and 7) may be part of the family based on sequence similarity.
R-HSA-914017 (Reactome) An unknown N-acetylgalactosaminyltransferase mediates the transfer of GalNAc is transferred to Tn antigens via an alpha-1,6 linkage to create Core 7 mucins (Brockhausen et al. 2009).
R-HSA-914018 (Reactome) The glycosyltransferase GCNT3 mediates core 2 and core 4 O-glycan branching (Yeh et al, 1999; Schwientek et al, 1999).
R-HSA-977071 (Reactome) Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1) transfers sialic acid (Neu5Ac) from the donor CMP-Neu5Ac to galactose-containing acceptor substrates such as the Tn antigen (Stamenkovic et al. 1990).
R-HSA-977228 (Reactome) Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1) transfers sialic acid (Neu5Ac) from the donor CMP-Neu5Ac to the T antigen (Stamenkovic et al. 1990).
R-HSA-981497 (Reactome) The human genes ST3GAL1-4 encode for sialyltransferases1-4 respectively (Shang et al. 1999, Kim et al. 1996, Kitagawa & Paulson 1993, Basu et al. 1993). They add silaic acid (Neu5Ac) onto the T antigen forming an alpha-3-sialyl O-glycan.
R-HSA-981809 (Reactome) The human genes ST6GALNAC3 and 4 encode GalNAc alpha-2,6-sialyltransferase III and IV respectively which can add sialic acid (Neu5Ac) to sialyl T antigen to produce a disialyl T antigen. ST6GALNAC4 is characterised (Harduin-Lepers et al. 2000) while ST6GALNAC3 is thought to perform a similar function based on sequence similarity.
R-HSA-981814 (Reactome) The huma gene ST6GALNAC2 encodes GalNAc alpha-2,6-sialyltransferase II which mediates the transfer of sialic acid (Neu5Ac) onto the T antigen (Samyn-Petit et al. 2000).
ST3GAL1-4mim-catalysisR-HSA-981497 (Reactome)
ST6GAL1mim-catalysisR-HSA-977071 (Reactome)
ST6GAL1mim-catalysisR-HSA-977228 (Reactome)
ST6GALNAC2mim-catalysisR-HSA-981814 (Reactome)
ST6GALNAC3/4mim-catalysisR-HSA-981809 (Reactome)
Sialyl Tn antigensArrowR-HSA-977071 (Reactome)
Sialyl-2,3 T antigensArrowR-HSA-981497 (Reactome)
Sialyl-2,3 T antigensR-HSA-981809 (Reactome)
Sialyl-2,6 T antigensArrowR-HSA-977228 (Reactome)
Sialyl-2,6 T antigensArrowR-HSA-981814 (Reactome)
Tn antigensArrowR-HSA-913675 (Reactome)
Tn antigensR-HSA-1964505 (Reactome)
Tn antigensR-HSA-914005 (Reactome)
Tn antigensR-HSA-914006 (Reactome)
Tn antigensR-HSA-914008 (Reactome)
Tn antigensR-HSA-914010 (Reactome)
Tn antigensR-HSA-914017 (Reactome)
Tn antigensR-HSA-977071 (Reactome)
UDP-GalNAcR-HSA-913675 (Reactome)
UDP-GalNAcR-HSA-914017 (Reactome)
UDP-GalR-HSA-1964501 (Reactome)
UDP-GalR-HSA-1964505 (Reactome)
UDP-GalR-HSA-914006 (Reactome)
UDP-GlcNAcR-HSA-5694487 (Reactome)
UDP-GlcNAcR-HSA-914005 (Reactome)
UDP-GlcNAcR-HSA-914008 (Reactome)
UDP-GlcNAcR-HSA-914010 (Reactome)
UDP-GlcNAcR-HSA-914012 (Reactome)
UDP-GlcNAcR-HSA-914018 (Reactome)
UDP-GlcR-HSA-5173005 (Reactome)
UDPArrowR-HSA-1964501 (Reactome)
UDPArrowR-HSA-1964505 (Reactome)
UDPArrowR-HSA-5173005 (Reactome)
UDPArrowR-HSA-5694487 (Reactome)
UDPArrowR-HSA-913675 (Reactome)
UDPArrowR-HSA-914005 (Reactome)
UDPArrowR-HSA-914006 (Reactome)
UDPArrowR-HSA-914008 (Reactome)
UDPArrowR-HSA-914010 (Reactome)
UDPArrowR-HSA-914012 (Reactome)
UDPArrowR-HSA-914017 (Reactome)
UDPArrowR-HSA-914018 (Reactome)
extended Core 6 mucinsArrowR-HSA-1964501 (Reactome)
glc-fuc-proteinsArrowR-HSA-5173005 (Reactome)
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3315"
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