Activation of gene expression by SREBF (SREBP) (Homo sapiens)

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15, 36, 391218, 331910164133, 3622522, 10, 334, 6, 27, 31, 33...211138262873230233422, 19, 33, 36242, 20, 33, 3612291333, 352, 3, 33, 36, 37, 4022, 33, 362, 332, 20, 36, 37339, 378mitochondrial outer membraneendoplasmic reticulum membranecytosolnucleoplasmSREBF1A,C SREBP1A,2:NF-Y:SC5DLgeneSREBF1A,1C,2 cleaved by S2P SQLE geneNFYA TBL1XR1 DHCR7 geneSQLE gene SREBF1A,1C,2 cleaved by S2P SC5DL gene Peroxisome Proliferator Receptor Element (PPRE) SREBF1A,2 GGPS1 gene NF-YMVDMVK gene ACACBACACB geneNFYB SP1 Coactivators of PPARalpha SREBF1A,C SP1ACACB gene ELOVL6IDI1HMGCS1PMVK geneSP1 NFYC SREBF1A,2 SREBF1A,2 SREBP1A,1C,2:ELOVL6geneSP1 ACACA geneSREBP1A,2:NF-Y:SP1:IDI1 genePPARA SREBP1A,2:NF-Y:HMGCRgeneCYP51A1 geneHMGCS1 gene NFYA MVKNFYB NFYA TM7SF2 geneNFYC TBL1XR1 SREBP1A,1C:ACACAgenePPARA NFYB NFYA SREBP1A,2:NF-Y:SP1:DHCR7 geneRXRA SP1 FDFT1 geneCYP51A1NFYC TBL1XR1 FASN gene Ligands of PPARA SP1 SQLENFYA SP1 PPARA:RXRACoactivator complexLigands of PPARA TM7SF2FASNSREBP1A,2:SQLE geneLSS gene NFYB PPARA:RXRACoactivator complexFDPS geneHMGCR-1FDFT1 gene SREBP1A,1C,2 dimerNFYB DHCR7 gene HMGCR gene SP1 SREBP1A,2:NF-Y:SP1:MVK geneNFYA ELOVL6 gene NFYA SREBP1A,1C,2:NF-Y:SP1:FDFT1 geneNFYC SREBF1A,C Peroxisome Proliferator Receptor Element (PPRE) FDFT1SREBP1A,1C,2:NF-Y:HMGCS1 geneNFYA LSSIDI1 gene NFYB SP1 HMGCS1 geneNFYA NFYA SREBF1A,2 SREBF1A,2 SREBP1A,2 dimerSREBF1A,1C,2 cleaved by S2P IDI1 geneMVD geneELOVL6 geneNFYC SREBP1A,1C:NF-Y:GPAMgeneSREBP1A,1C,2:NF-Y:TM7SF2 geneNFYA SREBP1A,2:LSS geneNFYC SREBP1A,2:NF-Y:SP1:GGPS1 geneMVD gene GGPS1DHCR7SREBP1A,2:NF-Y:SP1:PMVK geneNFYC NFYB NF-YSREBF1A,2 SREBP1A,1C dimerGPAM gene NFYC RXRA Coactivators of PPARalpha NFYC SREBF1A,1C,2 cleaved by S2P NFYC NFYC SP1NFYC SREBF1A,2 TM7SF2 gene NFYB NFYB SREBP1A,1C:ACACBgeneFDPS gene SREBF1A,2 PMVK gene SREBF1A,2 SREBF1A,2 Coactivators of PPARalpha NFYC NFYC ACACASP1 TBL1X NFYB MVK geneNFYA NFYA NFYA NFYB SREBP1A,1C,2:NF-Y:FDPS geneSREBF1A,1C,2 cleaved by S2P PMVKSREBF1A,2 FDPSGGPS1 geneNFYB NFYB HMGCR geneNFYB Peroxisome Proliferator Receptor Element (PPRE) NFYA TBL1X NFYC NFYB SREBP1A,2:MVD geneNFYB SREBP1A,2:NF-Y:SP1:CYP51A1 geneLigands of PPARA GPAM(1-828)CYP51A1 gene SC5DNFYA NFYC PPARA:RXRACoactivator complexFASN geneACACA gene SREBF1A,2 GPAM genePPARA LSS geneNFYB TBL1X SREBF1A,C NFYC SREBP1A,1C:NF-Y:SP1:FASN geneSREBF1A,C NFYA SREBF1A,1C,2 cleaved by S2P RXRA SC5DL gene5, 142, 3, 10, 3525, 142222217225, 14222, 312222222172


Description

After transiting to the nucleus SREBPs (SREBP1A/1C/2, SREBFs) bind short sequences, sterol regulatory elements (SREs), in the promoters of target genes (reviewed in Eberle et al. 2004, Weber et al. 2004). SREBPs alone are relatively weak activators of transcription, with SREBP1C being significantly weaker than SREBP1A or SREBP2. In combination with other transcription factors such as SP1 and NF-Y the SREBPs are much stronger activators. SREBP1C seems to more specifically target genes involved in fatty acid synthesis while SREBP2 seems to target genes involved in cholesterol synthesis (Pai et al. 1998). View original pathway at:Reactome.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
123263view09:02, 9 July 2022EgonwIt was there twice
123261view08:50, 9 July 2022EgonwReplaced an old Ensembl identifier
114667view16:13, 25 January 2021ReactomeTeamReactome version 75
114381view12:04, 9 January 2021EgonwUpdated Ensembl identifier
113058view10:58, 2 November 2020ReactomeTeamReactome version 74
112290view15:12, 9 October 2020ReactomeTeamReactome version 73
103006view15:08, 31 January 2019Mkutmonupdated outdated Ensembl identifiers
101249view11:14, 1 November 2018ReactomeTeamreactome version 66
100788view20:41, 31 October 2018ReactomeTeamreactome version 65
100330view19:18, 31 October 2018ReactomeTeamreactome version 64
99875view16:02, 31 October 2018ReactomeTeamreactome version 63
99432view14:36, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
93743view13:33, 16 August 2017ReactomeTeamreactome version 61
93257view11:18, 9 August 2017ReactomeTeamreactome version 61
87078view14:22, 18 July 2016MkutmonOntology Term : 'transcription pathway' added !
87077view14:21, 18 July 2016MkutmonOntology Term : 'sterol regulatory element-binding protein signaling pathway' added !
86336view09:15, 11 July 2016ReactomeTeamreactome version 56
83318view10:46, 18 November 2015ReactomeTeamVersion54
81757view09:58, 26 August 2015ReactomeTeamVersion53
76917view08:18, 17 July 2014ReactomeTeamFixed remaining interactions
76622view11:59, 16 July 2014ReactomeTeamFixed remaining interactions
75953view10:01, 11 June 2014ReactomeTeamRe-fixing comment source
75655view10:55, 10 June 2014ReactomeTeamReactome 48 Update
75010view13:52, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74843view10:07, 30 April 2014ReactomeTeamReactome46
74654view08:42, 30 April 2014ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACACA gene ProteinENSG00000132142 (Ensembl)
ACACA geneENSG00000132142 (Ensembl)
ACACAProteinQ13085 (Uniprot-TrEMBL)
ACACB gene ProteinENSG00000076555 (Ensembl)
ACACB geneENSG00000076555 (Ensembl)
ACACBProteinO00763 (Uniprot-TrEMBL)
CYP51A1 gene ProteinENSG00000067064 (Ensembl)
CYP51A1 geneENSG00000067064 (Ensembl)
CYP51A1ProteinQ16850 (Uniprot-TrEMBL)
Coactivators of PPARalpha R-HSA-400216 (Reactome)
DHCR7 gene ProteinENSG00000172893 (Ensembl)
DHCR7 geneENSG00000172893 (Ensembl)
DHCR7ProteinQ9UBM7 (Uniprot-TrEMBL)
ELOVL6 gene ProteinENSG00000170522 (Ensembl)
ELOVL6 geneENSG00000170522 (Ensembl)
ELOVL6ProteinQ9H5J4 (Uniprot-TrEMBL)
FASN gene ProteinENSG00000169710 (Ensembl)
FASN geneENSG00000169710 (Ensembl)
FASNProteinP49327 (Uniprot-TrEMBL)
FDFT1 gene ProteinENSG00000079459 (Ensembl)
FDFT1 geneENSG00000079459 (Ensembl)
FDFT1ProteinP37268 (Uniprot-TrEMBL)
FDPS gene ProteinENSG00000160752 (Ensembl)
FDPS geneENSG00000160752 (Ensembl)
FDPSProteinP14324 (Uniprot-TrEMBL)
GGPS1 gene ProteinENSG00000152904 (Ensembl)
GGPS1 geneENSG00000152904 (Ensembl)
GGPS1ProteinO95749 (Uniprot-TrEMBL)
GPAM gene ProteinENSG00000119927 (Ensembl)
GPAM geneENSG00000119927 (Ensembl)
GPAM(1-828)ProteinQ9HCL2 (Uniprot-TrEMBL)
HMGCR gene ProteinENSG00000113161 (Ensembl)
HMGCR geneENSG00000113161 (Ensembl)
HMGCR-1ProteinP04035-1 (Uniprot-TrEMBL)
HMGCS1 gene ProteinENSG00000112972 (Ensembl)
HMGCS1 geneENSG00000112972 (Ensembl)
HMGCS1ProteinQ01581 (Uniprot-TrEMBL)
IDI1 gene ProteinENSG00000067064 (Ensembl)
IDI1 geneENSG00000067064 (Ensembl)
IDI1ProteinQ13907 (Uniprot-TrEMBL)
LSS gene ProteinENSG00000160285 (Ensembl)
LSS geneENSG00000160285 (Ensembl)
LSSProteinP48449 (Uniprot-TrEMBL)
Ligands of PPARA R-ALL-400149 (Reactome) PPAR-alpha is most efficiently activated by polyunsaturated fatty acids having 18-20 carbon groups and 3-5 double bonds.
MVD gene ProteinENSG00000167508 (Ensembl)
MVD geneENSG00000167508 (Ensembl)
MVDProteinP53602 (Uniprot-TrEMBL)
MVK gene ProteinENSG00000110921 (Ensembl)
MVK geneENSG00000110921 (Ensembl)
MVKProteinQ03426 (Uniprot-TrEMBL)
NF-YComplexR-HSA-381204 (Reactome) NF-Y is a ubiquitous heterotrimeric transcription factor comprising subunits NF-Y A, NF-Y B, and NF-Y C. It binds the sequence CCAAT.
NFYA ProteinP23511 (Uniprot-TrEMBL)
NFYB ProteinP25208 (Uniprot-TrEMBL)
NFYC ProteinQ13952 (Uniprot-TrEMBL)
PMVK gene ProteinENSG00000163344 (Ensembl)
PMVK geneENSG00000163344 (Ensembl)
PMVKProteinQ15126 (Uniprot-TrEMBL)
PPARA ProteinQ07869 (Uniprot-TrEMBL)
PPARA:RXRA Coactivator complexComplexR-HSA-400154 (Reactome)
Peroxisome Proliferator Receptor Element (PPRE) R-NUL-422139 (Reactome) Peroxisome proliferator receptor elements bind heterodimers containing a peroxisome proliferator receptor and a retinoic acid receptor. The consensus sequence is TGAMCTTTGNCCTAGWTYYG.
RXRA ProteinP19793 (Uniprot-TrEMBL)
SC5DL gene ProteinENSG00000109929 (Ensembl)
SC5DL geneENSG00000109929 (Ensembl)
SC5DProteinO75845 (Uniprot-TrEMBL)
SP1 ProteinP08047 (Uniprot-TrEMBL)
SP1ProteinP08047 (Uniprot-TrEMBL)
SQLE gene ProteinENSG00000104549 (Ensembl)
SQLE geneENSG00000104549 (Ensembl)
SQLEProteinQ14534 (Uniprot-TrEMBL)
SREBF1A,1C,2 cleaved by S2P R-HSA-1655720 (Reactome)
SREBF1A,2 R-HSA-1655734 (Reactome)
SREBF1A,C R-HSA-1655729 (Reactome)
SREBP1A,1C dimerComplexR-HSA-2065537 (Reactome)
SREBP1A,1C,2 dimerComplexR-HSA-1655744 (Reactome)
SREBP1A,1C,2:ELOVL6 geneComplexR-HSA-1655762 (Reactome)
SREBP1A,1C,2:NF-Y:FDPS geneComplexR-HSA-2426134 (Reactome)
SREBP1A,1C,2:NF-Y:HMGCS1 geneComplexR-HSA-2426129 (Reactome)
SREBP1A,1C,2:NF-Y:SP1:FDFT1 geneComplexR-HSA-2426135 (Reactome)
SREBP1A,1C,2:NF-Y:TM7SF2 geneComplexR-HSA-1655714 (Reactome)
SREBP1A,1C:ACACA geneComplexR-HSA-2426141 (Reactome)
SREBP1A,1C:ACACB geneComplexR-HSA-2426125 (Reactome)
SREBP1A,1C:NF-Y:GPAM geneComplexR-HSA-2426131 (Reactome)
SREBP1A,1C:NF-Y:SP1:FASN geneComplexR-HSA-1655738 (Reactome)
SREBP1A,2 dimerComplexR-HSA-2065551 (Reactome)
SREBP1A,2:LSS geneComplexR-HSA-2426137 (Reactome)
SREBP1A,2:MVD geneComplexR-HSA-2426130 (Reactome)
SREBP1A,2:NF-Y:HMGCR geneComplexR-HSA-2426128 (Reactome)
SREBP1A,2:NF-Y:SC5DL geneComplexR-HSA-2426140 (Reactome)
SREBP1A,2:NF-Y:SP1:CYP51A1 geneComplexR-HSA-2426132 (Reactome)
SREBP1A,2:NF-Y:SP1:DHCR7 geneComplexR-HSA-2426124 (Reactome)
SREBP1A,2:NF-Y:SP1:GGPS1 geneComplexR-HSA-2426126 (Reactome)
SREBP1A,2:NF-Y:SP1:IDI1 geneComplexR-HSA-2426138 (Reactome)
SREBP1A,2:NF-Y:SP1:MVK geneComplexR-HSA-2426127 (Reactome)
SREBP1A,2:NF-Y:SP1:PMVK geneComplexR-HSA-2426139 (Reactome)
SREBP1A,2:SQLE geneComplexR-HSA-2426136 (Reactome)
TBL1X ProteinO60907 (Uniprot-TrEMBL)
TBL1XR1 ProteinQ9BZK7 (Uniprot-TrEMBL)
TM7SF2 gene ProteinENSG00000149809 (Ensembl)
TM7SF2 geneENSG00000149809 (Ensembl)
TM7SF2ProteinO76062 (Uniprot-TrEMBL)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
ACACA geneR-HSA-2426160 (Reactome)
ACACAArrowR-HSA-1655845 (Reactome)
ACACB geneR-HSA-2426153 (Reactome)
ACACBArrowR-HSA-1655830 (Reactome)
CYP51A1 geneR-HSA-2426163 (Reactome)
CYP51A1ArrowR-HSA-1655847 (Reactome)
DHCR7 geneR-HSA-2426155 (Reactome)
DHCR7ArrowR-HSA-1655827 (Reactome)
ELOVL6 geneR-HSA-2426149 (Reactome)
ELOVL6ArrowR-HSA-1655835 (Reactome)
FASN geneR-HSA-2426148 (Reactome)
FASNArrowR-HSA-1655843 (Reactome)
FDFT1 geneR-HSA-2426146 (Reactome)
FDFT1ArrowR-HSA-1655850 (Reactome)
FDPS geneR-HSA-2426147 (Reactome)
FDPSArrowR-HSA-1655824 (Reactome)
GGPS1 geneR-HSA-2426161 (Reactome)
GGPS1ArrowR-HSA-1655832 (Reactome)
GPAM geneR-HSA-2426158 (Reactome)
GPAM(1-828)ArrowR-HSA-1655837 (Reactome)
HMGCR geneR-HSA-2426162 (Reactome)
HMGCR-1ArrowR-HSA-1655826 (Reactome)
HMGCS1 geneR-HSA-2426150 (Reactome)
HMGCS1ArrowR-HSA-1655848 (Reactome)
IDI1 geneR-HSA-2426152 (Reactome)
IDI1ArrowR-HSA-1655823 (Reactome)
LSS geneR-HSA-2426154 (Reactome)
LSSArrowR-HSA-1655828 (Reactome)
MVD geneR-HSA-2426144 (Reactome)
MVDArrowR-HSA-1655836 (Reactome)
MVK geneR-HSA-2426157 (Reactome)
MVKArrowR-HSA-1655846 (Reactome)
NF-YR-HSA-2065966 (Reactome)
NF-YR-HSA-2426146 (Reactome)
NF-YR-HSA-2426147 (Reactome)
NF-YR-HSA-2426148 (Reactome)
NF-YR-HSA-2426150 (Reactome)
NF-YR-HSA-2426151 (Reactome)
NF-YR-HSA-2426152 (Reactome)
NF-YR-HSA-2426155 (Reactome)
NF-YR-HSA-2426156 (Reactome)
NF-YR-HSA-2426157 (Reactome)
NF-YR-HSA-2426158 (Reactome)
NF-YR-HSA-2426161 (Reactome)
NF-YR-HSA-2426162 (Reactome)
NF-YR-HSA-2426163 (Reactome)
NF-YR-HSA-2426164 (Reactome)
PMVK geneR-HSA-2426156 (Reactome)
PMVKArrowR-HSA-1655839 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1655826 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1655848 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1655850 (Reactome)
R-HSA-1655823 (Reactome) The IDI1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655824 (Reactome) The FDPS gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655826 (Reactome) The HMGCR gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655827 (Reactome) The DHCR7 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655828 (Reactome) The LSS gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655830 (Reactome) The ACACB gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655832 (Reactome) The GGPS1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655833 (Reactome) The TM7SF2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655835 (Reactome) The ELOVL6 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655836 (Reactome) The MVD gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655837 (Reactome) The GPAM gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655839 (Reactome) The PMVK gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655843 (Reactome) The FASN gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655844 (Reactome) The SQLE gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655845 (Reactome) The ACACA gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655846 (Reactome) The MVK gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655847 (Reactome) The CYP51A1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655848 (Reactome) The HMGCS1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655850 (Reactome) The FDFT1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655852 (Reactome) The SC5D gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-2065966 (Reactome) SREBP2 (SREBF2) binds and transactivates an unusual sterol regulatory element in the promoter of the TM7SF2 gene (Schiavoni et al. 2010). NF-Y binds the promoter and is important for activation by SREBP2. SREBP1A and SREBP1C can also bind the TM7SF2 promoter (Reed et al. 2008, Rome et al. 2008).
R-HSA-2426144 (Reactome) SREBP1A (SREBF1A) or SREBP2 binds and transactivates the promoter of the MVD gene (Rome et al. 2008).
R-HSA-2426146 (Reactome) SREBP1A/1C/2 (SREBF1A/1C/2), together with NF-Y and SP1, bind and transactivate the promoter of the FDFT1 gene (Inoue et al. 1998, Pai et al. 1998, Reed et al. 2008, Rome et al. 2008). SREBP2 activates FDFT1 more strongly than does SREBP1A (Pai et al. 1998).
R-HSA-2426147 (Reactome) SREBP1A/1C/2 (SREBF1A/1C/2), together with NF-Y, bind and transactivate the promoter of the FDPS gene (Ericsson et al. 1996, Pai et al. 1998, Amemiya-Kudo et al. 2002, Reed et al. 2008, Rome et al. 2008, Ishimoto et al. 2010). The binding of NF-Y synergistically enhances the binding of SREBP1 (Ericsson et al. 1996). SREBP1A activates FDPS more strongly than does SREBP2 or SREBP1C (Amemiya-Kudo et al. 2002).
R-HSA-2426148 (Reactome) SREBP1A (SREBF1A) or SREBP1C, together with NF-Y and SP1, bind and transactivate the promoter of the FASN gene (Bennett et al. 1995, Pai et al. 1998, Xiong et al. 2000, Amemiya-Kudo et al. 2002, Shin et al. 2007, Choi et al. 2008, Rome et al. 2008). NF-Y is required for response to cholesterol (Xiong et al. 2000). SREBP1A activates FASN more strongly than does SREBP1C or SREBP2 (Pai et al. 1998, Amemiya-Kudo et al. 2002).
R-HSA-2426149 (Reactome) As inferred from mouse, SREBP1A/1C/2 (SREBF1A/1C/2) binds and transactivates the promoter of the ELOVL6 gene.
R-HSA-2426150 (Reactome) SREBP1A/1C/2 (SREBF1A/1C/2), together with NF-Y, bind and transactivate the promoter of the HMGCS1 gene (Maeda et al. 1998, Pai et al. 1998, Amemiya-Kudo et al. 2002, Reed et al. 2008). SREBP1A and SREBP2 activate HMGCS1 equally (Pai et al. 1998).
R-HSA-2426151 (Reactome) SREBP1A (SREBF1A) or SREBP2 binds and transactivates the promoter of the SQLE gene (Reed et al. 2008). The promoter also contains a consensus binding site for NF-Y (Nagai et al. 2002).
R-HSA-2426152 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the IDI1 gene (Reed et al. 2008).
R-HSA-2426153 (Reactome) SREBP1A (SREBF1A) or SREBP1C, together with SP1, bind and transactivate promoter II of the ACACB gene in human HepG2 cells (Oh et al. 2003).
R-HSA-2426154 (Reactome) SREBP1A (SREBF1A) or SREBP2 binds and transactivates the promoter of the LSS gene (Pai et al. 1998, Rome et al. 2008). SREBP1A and SREBP2 activate LSS equally (Pai et al. 1998).
R-HSA-2426155 (Reactome) SREBP1A (SREBF1A) and SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the DHCR7 gene (Reed et al. 2008).
R-HSA-2426156 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the PMVK gene (Reed et al. 2008).
R-HSA-2426157 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the MVK gene (Reed et al. 2008).
R-HSA-2426158 (Reactome) SREBP1A (SREBF1A) or SREBP1C bind and transactivate promoter II of the GPAM gene (Harada et al. 2012). Promoter II is active in lipogenic tissues. As inferred from mouse, NF-Y also binds the GPAM promoter with SREBP1A/1C.
R-HSA-2426160 (Reactome) SREBP1A (SREBF1A) or SREBP1C bind two sites in the promoter of the ACACA gene (Magana et al. 1997, Rome et al. 2008). Each site is required for activation of transcription.
R-HSA-2426161 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the GGPS1 gene (Reed et al. 2008).
R-HSA-2426162 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y, bind and transactivate the promoter of the HMGCR gene (Vallett et al. 1996, Pai et al. 1998, Reed et al. 2008, Rome et al. 2008). SREBP2 activates HMGCR slightly more than does SREBP1A (Pai et al. 1998). SREBP1A/2 binds 2 main sites and 2 auxiliary sites in the HMGCR promoter (Vallett et al. 1996).
R-HSA-2426163 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the CYP51A1 gene (Pai et al. 1998, Reed et al. 2008, Rome et al. 2008). SREBP1A and SREBP2 activate CYP51A1 equally (Pai et al. 1998).
R-HSA-2426164 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y, bind and transactivate the promoter of the SC5DL gene (Reed et al. 2008, Rome et al. 2008).
SC5DArrowR-HSA-1655852 (Reactome)
SC5DL geneR-HSA-2426164 (Reactome)
SP1R-HSA-2426146 (Reactome)
SP1R-HSA-2426148 (Reactome)
SP1R-HSA-2426152 (Reactome)
SP1R-HSA-2426153 (Reactome)
SP1R-HSA-2426155 (Reactome)
SP1R-HSA-2426156 (Reactome)
SP1R-HSA-2426157 (Reactome)
SP1R-HSA-2426161 (Reactome)
SP1R-HSA-2426163 (Reactome)
SQLE geneR-HSA-2426151 (Reactome)
SQLEArrowR-HSA-1655844 (Reactome)
SREBP1A,1C dimerR-HSA-2426148 (Reactome)
SREBP1A,1C dimerR-HSA-2426153 (Reactome)
SREBP1A,1C dimerR-HSA-2426158 (Reactome)
SREBP1A,1C dimerR-HSA-2426160 (Reactome)
SREBP1A,1C,2 dimerR-HSA-2065966 (Reactome)
SREBP1A,1C,2 dimerR-HSA-2426146 (Reactome)
SREBP1A,1C,2 dimerR-HSA-2426147 (Reactome)
SREBP1A,1C,2 dimerR-HSA-2426149 (Reactome)
SREBP1A,1C,2 dimerR-HSA-2426150 (Reactome)
SREBP1A,1C,2:ELOVL6 geneArrowR-HSA-1655835 (Reactome)
SREBP1A,1C,2:ELOVL6 geneArrowR-HSA-2426149 (Reactome)
SREBP1A,1C,2:ELOVL6 geneR-HSA-1655835 (Reactome)
SREBP1A,1C,2:NF-Y:FDPS geneArrowR-HSA-1655824 (Reactome)
SREBP1A,1C,2:NF-Y:FDPS geneArrowR-HSA-2426147 (Reactome)
SREBP1A,1C,2:NF-Y:FDPS geneR-HSA-1655824 (Reactome)
SREBP1A,1C,2:NF-Y:HMGCS1 geneArrowR-HSA-1655848 (Reactome)
SREBP1A,1C,2:NF-Y:HMGCS1 geneArrowR-HSA-2426150 (Reactome)
SREBP1A,1C,2:NF-Y:HMGCS1 geneR-HSA-1655848 (Reactome)
SREBP1A,1C,2:NF-Y:SP1:FDFT1 geneArrowR-HSA-1655850 (Reactome)
SREBP1A,1C,2:NF-Y:SP1:FDFT1 geneArrowR-HSA-2426146 (Reactome)
SREBP1A,1C,2:NF-Y:SP1:FDFT1 geneR-HSA-1655850 (Reactome)
SREBP1A,1C,2:NF-Y:TM7SF2 geneArrowR-HSA-1655833 (Reactome)
SREBP1A,1C,2:NF-Y:TM7SF2 geneArrowR-HSA-2065966 (Reactome)
SREBP1A,1C,2:NF-Y:TM7SF2 geneR-HSA-1655833 (Reactome)
SREBP1A,1C:ACACA geneArrowR-HSA-1655845 (Reactome)
SREBP1A,1C:ACACA geneArrowR-HSA-2426160 (Reactome)
SREBP1A,1C:ACACA geneR-HSA-1655845 (Reactome)
SREBP1A,1C:ACACB geneArrowR-HSA-1655830 (Reactome)
SREBP1A,1C:ACACB geneArrowR-HSA-2426153 (Reactome)
SREBP1A,1C:ACACB geneR-HSA-1655830 (Reactome)
SREBP1A,1C:NF-Y:GPAM geneArrowR-HSA-1655837 (Reactome)
SREBP1A,1C:NF-Y:GPAM geneArrowR-HSA-2426158 (Reactome)
SREBP1A,1C:NF-Y:GPAM geneR-HSA-1655837 (Reactome)
SREBP1A,1C:NF-Y:SP1:FASN geneArrowR-HSA-1655843 (Reactome)
SREBP1A,1C:NF-Y:SP1:FASN geneArrowR-HSA-2426148 (Reactome)
SREBP1A,1C:NF-Y:SP1:FASN geneR-HSA-1655843 (Reactome)
SREBP1A,2 dimerR-HSA-2426144 (Reactome)
SREBP1A,2 dimerR-HSA-2426151 (Reactome)
SREBP1A,2 dimerR-HSA-2426152 (Reactome)
SREBP1A,2 dimerR-HSA-2426154 (Reactome)
SREBP1A,2 dimerR-HSA-2426155 (Reactome)
SREBP1A,2 dimerR-HSA-2426156 (Reactome)
SREBP1A,2 dimerR-HSA-2426157 (Reactome)
SREBP1A,2 dimerR-HSA-2426161 (Reactome)
SREBP1A,2 dimerR-HSA-2426162 (Reactome)
SREBP1A,2 dimerR-HSA-2426163 (Reactome)
SREBP1A,2 dimerR-HSA-2426164 (Reactome)
SREBP1A,2:LSS geneArrowR-HSA-1655828 (Reactome)
SREBP1A,2:LSS geneArrowR-HSA-2426154 (Reactome)
SREBP1A,2:LSS geneR-HSA-1655828 (Reactome)
SREBP1A,2:MVD geneArrowR-HSA-1655836 (Reactome)
SREBP1A,2:MVD geneArrowR-HSA-2426144 (Reactome)
SREBP1A,2:MVD geneR-HSA-1655836 (Reactome)
SREBP1A,2:NF-Y:HMGCR geneArrowR-HSA-1655826 (Reactome)
SREBP1A,2:NF-Y:HMGCR geneArrowR-HSA-2426162 (Reactome)
SREBP1A,2:NF-Y:HMGCR geneR-HSA-1655826 (Reactome)
SREBP1A,2:NF-Y:SC5DL geneArrowR-HSA-1655852 (Reactome)
SREBP1A,2:NF-Y:SC5DL geneArrowR-HSA-2426164 (Reactome)
SREBP1A,2:NF-Y:SC5DL geneR-HSA-1655852 (Reactome)
SREBP1A,2:NF-Y:SP1:CYP51A1 geneArrowR-HSA-1655847 (Reactome)
SREBP1A,2:NF-Y:SP1:CYP51A1 geneArrowR-HSA-2426163 (Reactome)
SREBP1A,2:NF-Y:SP1:CYP51A1 geneR-HSA-1655847 (Reactome)
SREBP1A,2:NF-Y:SP1:DHCR7 geneArrowR-HSA-1655827 (Reactome)
SREBP1A,2:NF-Y:SP1:DHCR7 geneArrowR-HSA-2426155 (Reactome)
SREBP1A,2:NF-Y:SP1:DHCR7 geneR-HSA-1655827 (Reactome)
SREBP1A,2:NF-Y:SP1:GGPS1 geneArrowR-HSA-1655832 (Reactome)
SREBP1A,2:NF-Y:SP1:GGPS1 geneArrowR-HSA-2426161 (Reactome)
SREBP1A,2:NF-Y:SP1:GGPS1 geneR-HSA-1655832 (Reactome)
SREBP1A,2:NF-Y:SP1:IDI1 geneArrowR-HSA-1655823 (Reactome)
SREBP1A,2:NF-Y:SP1:IDI1 geneArrowR-HSA-2426152 (Reactome)
SREBP1A,2:NF-Y:SP1:IDI1 geneR-HSA-1655823 (Reactome)
SREBP1A,2:NF-Y:SP1:MVK geneArrowR-HSA-1655846 (Reactome)
SREBP1A,2:NF-Y:SP1:MVK geneArrowR-HSA-2426157 (Reactome)
SREBP1A,2:NF-Y:SP1:MVK geneR-HSA-1655846 (Reactome)
SREBP1A,2:NF-Y:SP1:PMVK geneArrowR-HSA-1655839 (Reactome)
SREBP1A,2:NF-Y:SP1:PMVK geneArrowR-HSA-2426156 (Reactome)
SREBP1A,2:NF-Y:SP1:PMVK geneR-HSA-1655839 (Reactome)
SREBP1A,2:SQLE geneArrowR-HSA-1655844 (Reactome)
SREBP1A,2:SQLE geneArrowR-HSA-2426151 (Reactome)
SREBP1A,2:SQLE geneR-HSA-1655844 (Reactome)
TM7SF2 geneR-HSA-2065966 (Reactome)
TM7SF2ArrowR-HSA-1655833 (Reactome)
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