Regulation of lipid metabolism by PPARalpha (Homo sapiens)

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28, 39, 43, 515014, 27147, 1427272716, 4428, 30, 37, 39, 43...271427271, 14, 4027271414, 2748322, 273114, 2727, 4614, 27274514, 278, 92727, 335, 272711, 13142, 24, 25, 28, 30...10, 28, 30, 39, 43...145, 27, 52144136274227endoplasmic reticulum membranelipid particlemitochondrial outer membraneperoxisomal matrixmitochondrial matrixnucleoplasmcytosolNCOA2 PLIN2PPARA:RXRAheterodimerUGT1A9Peroxisome Proliferator Receptor Element (PPRE) p-S-ARNTL NCOA6 GRHL1 geneTEAD:WWTR1(TAZ)AGTRGZ CTGFABCB4PPARA:RXRACoactivator complexNCOA2 CYP7A1PLIN2 geneAPOA5 geneHDAC3 NCOA1 RXRA EPA NPAS2TEAD:YAP1MED25 YAP1 G0S2 geneNFYC HMGCS1 geneFDFT1 geneTBL1XR1 SLC27A1 geneFHL2 geneMED27 MED13L MED21 G0S2CREBBP TBL1X SREBF1-1(1-490) NCOA6 SREBF1-1(1-490) TXNRD1 geneNCOR1 APOA1(25-266)MED12 NFYC Peroxisome Proliferator Receptor Element (PPRE) HMGCS2 geneSREBF2(1-484) NCOA1 DCA SREBF1-3 HMGCR genePalm TEAD1 FABP1 MED19 ACSL1 geneCARM1 EP300 LCHA ALA LINA MED31 ESRRAMED1 ALA MED13 ALAS1Peroxisome Proliferator Receptor Element (PPRE) MED15 CARM1 CCNC PeroxisomeProliferatorReceptor Element(PPRE)MED6 PPARA MED23 WWTR1 TGS1 NFYA NPAS2 geneTBL1X TNFRSF21 geneTNFRSF21MED10 NCOA1 MED26 ferriheme b SREBF2(1-484) CYP4A11 geneMED14 NFYA TEAD3 p-BMAL1:p-CLOCK,NPAS2CTGF geneAPOA1 geneHDAC3 TEAD1 GLIPR1 geneABCA1 geneTRIB3 geneFABP1:ligands ofPPARACDCA FABP1ME1 geneRGL1 gene13(S')-HODE SREBF2(1-484) MED24 TIAM2TBL1XR1TEAD4 Corepressors ofPPARalphaSREBP1A,1C,2:NF-Y:HMGCS1 geneAA TEAD4 RXRA CPT2CYP4A11CHD9 RXRA HMGCR gene MED4 HMGCS1 gene NCOA3 MED16 AA TEAD3 APOA2(24-100)Coactivators ofPPARalphaALAS1gene:NRF1:PPARGC1BFHL2RXRA AGT genePPARGC1B ANGPTL geneME1ANKRD1 geneALAS1 gene Actos MED29 SIN3B-1 PEX11ACPT1A geneTBL1XSULT2A1 geneANKRD1NCOA2 FABP1 genePEX11A geneLINA NCOR1 NFYB SIN3A SIN3A ABCA1NFYC TBL1XR1 MED17 CREBBP GLIPR1PPARACREBBP NCOR1 FDFT1SREBP1A,1C,2:NF-Y:SP1:FDFT1 geneABCB4 geneNFYA TGS1 PPARG:FattyAcid:RXRA:Mediator:Coactivator ComplexCYP1A1 geneCDK8 SREBF1-3 ACOX1-1TEAD2 CHD9 NFYB NR1D1 RXRA GRHL1ANGPTL4MED9 PPARA:RXRACorepressor complexTRIB3HMGCS2ACOX1 geneFADS1EP300 NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHACDK19 APOA5CYP1A1NRIP1 FADS1 genePalm FDFT1 gene SIN3B-1 CPT1ASULT2A1APOA2 geneRORA ACADMNRF1 PPARGC1A SP1 MED8 NFYB HDAC3 ACADM geneMED22 MED1 HELZ2 HMGCR-1p-S-NPAS2 HELZ2 PPARA MED1 TEAD2 PPARG SLC27A1TIAM2 genePPARA geneSREBP1A,2:NF-Y:HMGCRgeneALAS1 geneNR1H4 MED30 RGL1CPT2RORA:CoactivatorHMGCS1NCOR2 NCOA2 RXRAMED20 HELZ2 9S-HODE MED18 SMARCD3 PPARGC1A UGT1A9 geneEPA NR1D1(REV-ERBA):heme:Corepressorp-S-CLOCK MED7 NCOR2 SMARCD3 TXNRD14xPalmC-CD36CYP7A1 geneCD36 geneSREBF1-1(1-490) ACSL1PPARA MED11 NCOA1 15154, 2311, 406, 1921211512, 4732, 3517, 20, 29, 49261832, 356, 19382121


Description

Peroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma lipid levels.
PPAR-alpha is a type II nuclear receptor (its subcellular location does not depend on ligand binding). PPAR-alpha forms heterodimers with Retinoid X receptor alpha (RXR-alpha), another type II nuclear receptor. PPAR-alpha is activated by binding fatty acid ligands, especially polyunsaturated fatty acids having 18-22 carbon groups and 2-6 double bonds.
The PPAR-alpha:RXR-alpha heterodimer binds peroxisome proliferator receptor elements (PPREs) in and around target genes. Binding of fatty acids and synthetic ligands causes a conformational change in PPAR-alpha such that it releases the corepressors and binds coactivators (CBP-SRC-HAT complex, ASC complex, and TRAP-Mediator complex) which initiate transcription of the target genes.
Target genes of PPAR-alpha participate in fatty acid transport, fatty acid oxidation, triglyceride clearance, lipoprotein production, and cholesterol homeostasis. View original pathway at:Reactome.

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Bibliography

View all...
  1. Hua F, Mu R, Liu J, Xue J, Wang Z, Lin H, Yang H, Chen X, Hu Z.; ''TRB3 interacts with SMAD3 promoting tumor cell migration and invasion.''; PubMed Europe PMC Scholia
  2. Vock C, Döring F, Nitz I.; ''Transcriptional regulation of HMG-CoA synthase and HMG-CoA reductase genes by human ACBP.''; PubMed Europe PMC Scholia
  3. Guo L, Guo ZX, Gong HP, Shang YY, Zhong M, Zhang Y, Zhang W.; ''Tribbles homolog 3 is induced by high glucose and associated with apoptosis in human endothelial cells.''; PubMed Europe PMC Scholia
  4. Haarmann-Stemmann T, Abel J.; ''The arylhydrocarbon receptor repressor (AhRR): structure, expression, and function.''; PubMed Europe PMC Scholia
  5. Krey G, Braissant O, L'Horset F, Kalkhoven E, Perroud M, Parker MG, Wahli W.; ''Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay.''; PubMed Europe PMC Scholia
  6. Mukherjee R, Jow L, Noonan D, McDonnell DP.; ''Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators.''; PubMed Europe PMC Scholia
  7. Blanquart C, Barbier O, Fruchart JC, Staels B, Glineur C.; ''Peroxisome proliferator-activated receptor alpha (PPARalpha ) turnover by the ubiquitin-proteasome system controls the ligand-induced expression level of its target genes.''; PubMed Europe PMC Scholia
  8. Krammer J, Digel M, Ehehalt F, Stremmel W, Füllekrug J, Ehehalt R.; ''Overexpression of CD36 and acyl-CoA synthetases FATP2, FATP4 and ACSL1 increases fatty acid uptake in human hepatoma cells.''; PubMed Europe PMC Scholia
  9. Amemiya-Kudo M, Shimano H, Hasty AH, Yahagi N, Yoshikawa T, Matsuzaka T, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Sato R, Kimura S, Ishibashi S, Yamada N.; ''Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes.''; PubMed Europe PMC Scholia
  10. Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W.; ''From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.''; PubMed Europe PMC Scholia
  11. Bardot O, Aldridge TC, Latruffe N, Green S.; ''PPAR-RXR heterodimer activates a peroxisome proliferator response element upstream of the bifunctional enzyme gene.''; PubMed Europe PMC Scholia
  12. Xu J, Lv S, Qin Y, Shu F, Xu Y, Chen J, Xu BE, Sun X, Wu J.; ''TRB3 interacts with CtIP and is overexpressed in certain cancers.''; PubMed Europe PMC Scholia
  13. van der Meer DL, Degenhardt T, Väisänen S, de Groot PJ, Heinäniemi M, de Vries SC, Müller M, Carlberg C, Kersten S.; ''Profiling of promoter occupancy by PPARalpha in human hepatoma cells via ChIP-chip analysis.''; PubMed Europe PMC Scholia
  14. Hahn ME, Allan LL, Sherr DH.; ''Regulation of constitutive and inducible AHR signaling: complex interactions involving the AHR repressor.''; PubMed Europe PMC Scholia
  15. Wolfrum C, Borrmann CM, Borchers T, Spener F.; ''Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors alpha - and gamma-mediated gene expression via liver fatty acid binding protein: a signaling path to the nucleus.''; PubMed Europe PMC Scholia
  16. Rakhshandehroo M, Hooiveld G, Müller M, Kersten S.; ''Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human.''; PubMed Europe PMC Scholia
  17. Zheng J, Shan Y, Lambrecht RW, Donohue SE, Bonkovsky HL.; ''Differential regulation of human ALAS1 mRNA and protein levels by heme and cobalt protoporphyrin.''; PubMed Europe PMC Scholia
  18. Roberts AG, Elder GH.; ''Alternative splicing and tissue-specific transcription of human and rodent ubiquitous 5-aminolevulinate synthase (ALAS1) genes.''; PubMed Europe PMC Scholia
  19. Beischlag TV, Luis Morales J, Hollingshead BD, Perdew GH.; ''The aryl hydrocarbon receptor complex and the control of gene expression.''; PubMed Europe PMC Scholia
  20. Jiang G, McKenzie TL, Conrad DG, Shechter I.; ''Transcriptional regulation by lovastatin and 25-hydroxycholesterol in HepG2 cells and molecular cloning and expression of the cDNA for the human hepatic squalene synthase.''; PubMed Europe PMC Scholia
  21. Johnson EF, Hsu MH, Savas U, Griffin KJ.; ''Regulation of P450 4A expression by peroxisome proliferator activated receptors.''; PubMed Europe PMC Scholia
  22. Qi C, Zhu Y, Reddy JK.; ''Peroxisome proliferator-activated receptors, coactivators, and downstream targets.''; PubMed Europe PMC Scholia
  23. Shimamoto Y, Hirota K, Fukamizu A.; ''Effect of peroxisome proliferator-activated receptor alpha on human angiotensinogen promoter.''; PubMed Europe PMC Scholia
  24. Barbier O, Villeneuve L, Bocher V, Fontaine C, Torra IP, Duhem C, Kosykh V, Fruchart JC, Guillemette C, Staels B.; ''The UDP-glucuronosyltransferase 1A9 enzyme is a peroxisome proliferator-activated receptor alpha and gamma target gene.''; PubMed Europe PMC Scholia
  25. Tian L, Zhou J, Casimiro MC, Liang B, Ojeifo JO, Wang M, Hyslop T, Wang C, Pestell RG.; ''Activating peroxisome proliferator-activated receptor gamma mutant promotes tumor growth in vivo by enhancing angiogenesis.''; PubMed Europe PMC Scholia
  26. Yang X, Lu X, Lombès M, Rha GB, Chi YI, Guerin TM, Smart EJ, Liu J.; ''The G(0)/G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase.''; PubMed Europe PMC Scholia
  27. Kersten S.; ''Peroxisome proliferator activated receptors and lipoprotein metabolism.''; PubMed Europe PMC Scholia
  28. Knutti D, Kaul A, Kralli A.; ''A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen.''; PubMed Europe PMC Scholia
  29. Zhou YD, Barnard M, Tian H, Li X, Ring HZ, Francke U, Shelton J, Richardson J, Russell DW, McKnight SL.; ''Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system.''; PubMed Europe PMC Scholia
  30. Vallett SM, Sanchez HB, Rosenfeld JM, Osborne TF.; ''A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene.''; PubMed Europe PMC Scholia
  31. Gouni-Berthold I, Krone W.; ''Peroxisome proliferator-activated receptor alpha (PPARalpha) and athero-sclerosis.''; PubMed Europe PMC Scholia
  32. Perissi V, Aggarwal A, Glass CK, Rose DW, Rosenfeld MG.; ''A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors.''; PubMed Europe PMC Scholia
  33. Mochizuki K, Suruga K, Fukami H, Kiso Y, Takase S, Goda T.; ''Selectivity of fatty acid ligands for PPARalpha which correlates both with binding to cis-element and DNA binding-independent transactivity in Caco-2 cells.''; PubMed Europe PMC Scholia
  34. Britton CH, Schultz RA, Zhang B, Esser V, Foster DW, McGarry JD.; ''Human liver mitochondrial carnitine palmitoyltransferase I: characterization of its cDNA and chromosomal localization and partial analysis of the gene.''; PubMed Europe PMC Scholia
  35. Fang HL, Strom SC, Cai H, Falany CN, Kocarek TA, Runge-Morris M.; ''Regulation of human hepatic hydroxysteroid sulfotransferase gene expression by the peroxisome proliferator-activated receptor alpha transcription factor.''; PubMed Europe PMC Scholia
  36. Yu S, Reddy JK.; ''Transcription coactivators for peroxisome proliferator-activated receptors.''; PubMed Europe PMC Scholia
  37. Matsumura R, Matsubara C, Node K, Takumi T, Akashi M.; ''Nuclear receptor-mediated cell-autonomous oscillatory expression of the circadian transcription factor, neuronal PAS domain protein 2 (NPAS2).''; PubMed Europe PMC Scholia
  38. Cheema SK, Agellon LB.; ''The murine and human cholesterol 7alpha-hydroxylase gene promoters are differentially responsive to regulation by fatty acids mediated via peroxisome proliferator-activated receptor alpha.''; PubMed Europe PMC Scholia
  39. Crumbley C, Wang Y, Kojetin DJ, Burris TP.; ''Characterization of the core mammalian clock component, NPAS2, as a REV-ERBalpha/RORalpha target gene.''; PubMed Europe PMC Scholia
  40. Lu X, Yang X, Liu J.; ''Differential control of ATGL-mediated lipid droplet degradation by CGI-58 and G0S2.''; PubMed Europe PMC Scholia
  41. Vu-Dac N, Chopin-Delannoy S, Gervois P, Bonnelye E, Martin G, Fruchart JC, Laudet V, Staels B.; ''The nuclear receptors peroxisome proliferator-activated receptor alpha and Rev-erbalpha mediate the species-specific regulation of apolipoprotein A-I expression by fibrates.''; PubMed Europe PMC Scholia
  42. Wang M, Yang F, Zhang X, Zhao H, Wang Q, Pan Y.; ''Comparative analysis of MTF-1 binding sites between human and mouse.''; PubMed Europe PMC Scholia
  43. Desvergne B, Wahli W.; ''Peroxisome proliferator-activated receptors: nuclear control of metabolism.''; PubMed Europe PMC Scholia
  44. Hostetler HA, McIntosh AL, Atshaves BP, Storey SM, Payne HR, Kier AB, Schroeder F.; ''L-FABP directly interacts with PPARalpha in cultured primary hepatocytes.''; PubMed Europe PMC Scholia
  45. Reed BD, Charos AE, Szekely AM, Weissman SM, Snyder M.; ''Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes.''; PubMed Europe PMC Scholia
  46. Juge-Aubry C, Pernin A, Favez T, Burger AG, Wahli W, Meier CA, Desvergne B.; ''DNA binding properties of peroxisome proliferator-activated receptor subtypes on various natural peroxisome proliferator response elements. Importance of the 5'-flanking region.''; PubMed Europe PMC Scholia
  47. Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM.; ''A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.''; PubMed Europe PMC Scholia
  48. Jakobsson T, Venteclef N, Toresson G, Damdimopoulos AE, Ehrlund A, Lou X, Sanyal S, Steffensen KR, Gustafsson JA, Treuter E.; ''GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus.''; PubMed Europe PMC Scholia
  49. Perera RJ, Marcusson EG, Koo S, Kang X, Kim Y, White N, Dean NM.; ''Identification of novel PPARgamma target genes in primary human adipocytes.''; PubMed Europe PMC Scholia
  50. Schachtrup C, Emmler T, Bleck B, Sandqvist A, Spener F.; ''Functional analysis of peroxisome-proliferator-responsive element motifs in genes of fatty acid-binding proteins.''; PubMed Europe PMC Scholia
  51. Tao N, Wagner SJ, Lublin DM.; ''CD36 is palmitoylated on both N- and C-terminal cytoplasmic tails.''; PubMed Europe PMC Scholia
  52. Liu MH, Li J, Shen P, Husna B, Tai ES, Yong EL.; ''A natural polymorphism in peroxisome proliferator-activated receptor-alpha hinge region attenuates transcription due to defective release of nuclear receptor corepressor from chromatin.''; PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
115040view16:58, 25 January 2021ReactomeTeamReactome version 75
113484view11:56, 2 November 2020ReactomeTeamReactome version 74
112683view16:07, 9 October 2020ReactomeTeamReactome version 73
109289view21:21, 5 March 2020KhanspersReverted to version '11:47, 1 November 2018' by Khanspers
109272view15:00, 3 March 2020ClorisModified title
101600view11:47, 1 November 2018ReactomeTeamreactome version 66
101136view21:32, 31 October 2018ReactomeTeamreactome version 65
100664view20:05, 31 October 2018ReactomeTeamreactome version 64
100214view16:50, 31 October 2018ReactomeTeamreactome version 63
99765view15:16, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99324view12:47, 31 October 2018ReactomeTeamreactome version 62
93918view13:44, 16 August 2017ReactomeTeamreactome version 61
93495view11:25, 9 August 2017ReactomeTeamreactome version 61
88142view12:57, 26 July 2016RyanmillerOntology Term : 'fatty acid metabolic pathway' added !
88141view12:56, 26 July 2016RyanmillerOntology Term : 'classic metabolic pathway' added !
86591view09:21, 11 July 2016ReactomeTeamreactome version 56
83414view11:10, 18 November 2015ReactomeTeamVersion54
81776view10:35, 26 August 2015ReactomeTeamVersion53
77088view08:38, 17 July 2014ReactomeTeamFixed remaining interactions
76794view12:17, 16 July 2014ReactomeTeamFixed remaining interactions
76117view10:18, 11 June 2014ReactomeTeamRe-fixing comment source
75829view11:39, 10 June 2014ReactomeTeamReactome 48 Update
75190view09:39, 9 May 2014AnweshaFixing comment source for displaying WikiPathways description
74834view10:06, 30 April 2014ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
13(S')-HODE MetaboliteCHEBI:34154 (ChEBI)
4xPalmC-CD36ProteinP16671 (Uniprot-TrEMBL)
9S-HODE MetaboliteCHEBI:34496 (ChEBI)
AA MetaboliteCHEBI:15843 (ChEBI)
ABCA1 geneGeneProductENSG00000165029 (Ensembl)
ABCA1ProteinO95477 (Uniprot-TrEMBL)
ABCB4 geneGeneProductENSG00000005471 (Ensembl)
ABCB4ProteinP21439 (Uniprot-TrEMBL)
ACADM geneGeneProductENSG00000117054 (Ensembl)
ACADMProteinP11310 (Uniprot-TrEMBL)
ACOX1 geneGeneProductENSG00000161533 (Ensembl)
ACOX1-1ProteinQ15067-1 (Uniprot-TrEMBL)
ACSL1 geneGeneProductENSG00000151726 (Ensembl)
ACSL1ProteinP33121 (Uniprot-TrEMBL)
AGT geneGeneProductENSG00000135744 (Ensembl)
AGTProteinP01019 (Uniprot-TrEMBL)
ALA MetaboliteCHEBI:27432 (ChEBI)
ALAS1 gene:NRF1:PPARGC1BComplexR-HSA-2466384 (Reactome)
ALAS1 gene ProteinENSG00000023330 (Ensembl)
ALAS1 geneGeneProductENSG00000023330 (Ensembl)
ALAS1ProteinP13196 (Uniprot-TrEMBL)
ANGPTL geneGeneProductENSG00000167772 (Ensembl)
ANGPTL4ProteinQ9BY76 (Uniprot-TrEMBL)
ANKRD1 geneGeneProductENSG00000148677 (Ensembl)
ANKRD1ProteinQ15327 (Uniprot-TrEMBL)
APOA1 geneGeneProductENSG00000118137 (Ensembl)
APOA1(25-266)ProteinP02647 (Uniprot-TrEMBL)
APOA2 geneGeneProductENSG00000158874 (Ensembl)
APOA2(24-100)ProteinP02652 (Uniprot-TrEMBL)
APOA5 geneGeneProductENSG00000110243 (Ensembl)
APOA5ProteinQ6Q788 (Uniprot-TrEMBL)
Actos MetaboliteCHEBI:8228 (ChEBI)
CARM1 ProteinQ86X55 (Uniprot-TrEMBL)
CCNC ProteinP24863 (Uniprot-TrEMBL)
CD36 geneGeneProductENSG00000135218 (Ensembl)
CDCA MetaboliteCHEBI:16755 (ChEBI)
CDK19 ProteinQ9BWU1 (Uniprot-TrEMBL)
CDK8 ProteinP49336 (Uniprot-TrEMBL)
CHD9 ProteinQ3L8U1 (Uniprot-TrEMBL)
CPT1A geneGeneProductENSG00000110090 (Ensembl)
CPT1AProteinP50416 (Uniprot-TrEMBL)
CPT2GeneProductENSG00000157184 (Ensembl)
CPT2ProteinP23786 (Uniprot-TrEMBL)
CREBBP ProteinQ92793 (Uniprot-TrEMBL)
CTGF geneGeneProductENSG00000118523 (Ensembl)
CTGFProteinP29279 (Uniprot-TrEMBL)
CYP1A1 geneGeneProductENSG00000140465 (Ensembl)
CYP1A1ProteinP04798 (Uniprot-TrEMBL)
CYP4A11 geneGeneProductENSG00000187048 (Ensembl)
CYP4A11ProteinQ02928 (Uniprot-TrEMBL)
CYP7A1 geneGeneProductENSG00000167910 (Ensembl)
CYP7A1ProteinP22680 (Uniprot-TrEMBL)
Coactivators of PPARalphaComplexR-HSA-400216 (Reactome)
Corepressors of PPARalphaComplexR-HSA-400207 (Reactome)
DCA MetaboliteCHEBI:28834 (ChEBI)
EP300 ProteinQ09472 (Uniprot-TrEMBL)
EPA MetaboliteCHEBI:28364 (ChEBI)
ESRRAProteinP11474 (Uniprot-TrEMBL)
FABP1 ProteinP07148 (Uniprot-TrEMBL) As inferred from mouse, FABP1 localizes to the nucleus where it may deliver lipids to PPARA.
FABP1 geneGeneProductENSG00000163586 (Ensembl)
FABP1:ligands of PPARAComplexR-HSA-2026984 (Reactome)
FABP1ProteinP07148 (Uniprot-TrEMBL) As inferred from mouse, FABP1 localizes to the nucleus where it may deliver lipids to PPARA.
FADS1 geneGeneProductENSG00000149485 (Ensembl)
FADS1ProteinO60427 (Uniprot-TrEMBL)
FDFT1 gene ProteinENSG00000079459 (Ensembl)
FDFT1 geneGeneProductENSG00000079459 (Ensembl)
FDFT1ProteinP37268 (Uniprot-TrEMBL)
FHL2 geneGeneProductENSG00000115641 (Ensembl)
FHL2ProteinQ14192 (Uniprot-TrEMBL)
G0S2 geneGeneProductENSG00000123689 (Ensembl)
G0S2ProteinP27469 (Uniprot-TrEMBL)
GLIPR1 geneGeneProductENSG00000139278 (Ensembl)
GLIPR1ProteinP48060 (Uniprot-TrEMBL)
GRHL1 geneGeneProductENSG00000134317 (Ensembl)
GRHL1ProteinQ9NZI5 (Uniprot-TrEMBL)
HDAC3 ProteinO15379 (Uniprot-TrEMBL)
HELZ2 ProteinQ9BYK8 (Uniprot-TrEMBL)
HMGCR gene ProteinENSG00000113161 (Ensembl)
HMGCR geneGeneProductENSG00000113161 (Ensembl)
HMGCR-1ProteinP04035-1 (Uniprot-TrEMBL)
HMGCS1 gene ProteinENSG00000112972 (Ensembl)
HMGCS1 geneGeneProductENSG00000112972 (Ensembl)
HMGCS1ProteinQ01581 (Uniprot-TrEMBL)
HMGCS2 geneGeneProductENSG00000134240 (Ensembl)
HMGCS2ProteinP54868 (Uniprot-TrEMBL)
LCHA MetaboliteCHEBI:16325 (ChEBI)
LINA MetaboliteCHEBI:17351 (ChEBI)
ME1 geneGeneProductENSG00000065833 (Ensembl)
ME1ProteinP48163 (Uniprot-TrEMBL)
MED1 ProteinQ15648 (Uniprot-TrEMBL) MED1 is a component of each of the various Mediator complexes, that function as transcription co-activators. The MED1-containing compolexes include the DRIP, ARC, TRIP and CRSP compllexes.
MED10 ProteinQ9BTT4 (Uniprot-TrEMBL)
MED11 ProteinQ9P086 (Uniprot-TrEMBL)
MED12 ProteinQ93074 (Uniprot-TrEMBL)
MED13 ProteinQ9UHV7 (Uniprot-TrEMBL)
MED13L ProteinQ71F56 (Uniprot-TrEMBL)
MED14 ProteinO60244 (Uniprot-TrEMBL)
MED15 ProteinQ96RN5 (Uniprot-TrEMBL)
MED16 ProteinQ9Y2X0 (Uniprot-TrEMBL)
MED17 ProteinQ9NVC6 (Uniprot-TrEMBL)
MED18 ProteinQ9BUE0 (Uniprot-TrEMBL)
MED19 ProteinA0JLT2 (Uniprot-TrEMBL)
MED20 ProteinQ9H944 (Uniprot-TrEMBL)
MED21 ProteinQ13503 (Uniprot-TrEMBL)
MED22 ProteinQ15528 (Uniprot-TrEMBL)
MED23 ProteinQ9ULK4 (Uniprot-TrEMBL)
MED24 ProteinO75448 (Uniprot-TrEMBL)
MED25 ProteinQ71SY5 (Uniprot-TrEMBL)
MED26 ProteinO95402 (Uniprot-TrEMBL)
MED27 ProteinQ6P2C8 (Uniprot-TrEMBL)
MED29 ProteinQ9NX70 (Uniprot-TrEMBL)
MED30 ProteinQ96HR3 (Uniprot-TrEMBL)
MED31 ProteinQ9Y3C7 (Uniprot-TrEMBL)
MED4 ProteinQ9NPJ6 (Uniprot-TrEMBL)
MED6 ProteinO75586 (Uniprot-TrEMBL)
MED7 ProteinO43513 (Uniprot-TrEMBL)
MED8 ProteinQ96G25 (Uniprot-TrEMBL)
MED9 ProteinQ9NWA0 (Uniprot-TrEMBL)
NCOA1 ProteinQ15788 (Uniprot-TrEMBL)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHAComplexR-HSA-5340274 (Reactome)
NCOA2 ProteinQ15596 (Uniprot-TrEMBL)
NCOA3 ProteinQ9Y6Q9 (Uniprot-TrEMBL)
NCOA6 ProteinQ14686 (Uniprot-TrEMBL)
NCOR1 ProteinO75376 (Uniprot-TrEMBL)
NCOR2 ProteinQ9Y618 (Uniprot-TrEMBL)
NFYA ProteinP23511 (Uniprot-TrEMBL)
NFYB ProteinP25208 (Uniprot-TrEMBL)
NFYC ProteinQ13952 (Uniprot-TrEMBL)
NPAS2 geneGeneProductENSG00000170485 (Ensembl)
NPAS2ProteinQ99743 (Uniprot-TrEMBL)
NR1D1 (REV-ERBA):heme:CorepressorComplexR-HSA-1368079 (Reactome)
NR1D1 ProteinP20393 (Uniprot-TrEMBL)
NR1H4 ProteinQ96RI1 (Uniprot-TrEMBL)
NRF1 ProteinQ16656 (Uniprot-TrEMBL)
NRIP1 ProteinP48552 (Uniprot-TrEMBL)
PEX11A geneGeneProductENSG00000166821 (Ensembl)
PEX11AProteinO75192 (Uniprot-TrEMBL)
PLIN2 geneGeneProductENSG00000147872 (Ensembl)
PLIN2ProteinQ99541 (Uniprot-TrEMBL)
PPARA ProteinQ07869 (Uniprot-TrEMBL)
PPARA geneGeneProductENSG00000186951 (Ensembl)
PPARA:RXRA Coactivator complexComplexR-HSA-400154 (Reactome)
PPARA:RXRA Corepressor complexComplexR-HSA-400196 (Reactome)
PPARA:RXRA heterodimerComplexR-HSA-400138 (Reactome)
PPARAProteinQ07869 (Uniprot-TrEMBL)
PPARG ProteinP37231 (Uniprot-TrEMBL)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator ComplexComplexR-HSA-381367 (Reactome)
PPARGC1A ProteinQ9UBK2 (Uniprot-TrEMBL)
PPARGC1B ProteinQ86YN6 (Uniprot-TrEMBL)
Palm MetaboliteCHEBI:15756 (ChEBI)
Peroxisome

Proliferator Receptor Element

(PPRE)		R-NUL-422139 (Reactome) Peroxisome proliferator receptor elements bind heterodimers containing a peroxisome proliferator receptor and a retinoic acid receptor. The consensus sequence is TGAMCTTTGNCCTAGWTYYG.
Peroxisome Proliferator Receptor Element (PPRE) R-NUL-422139 (Reactome) Peroxisome proliferator receptor elements bind heterodimers containing a peroxisome proliferator receptor and a retinoic acid receptor. The consensus sequence is TGAMCTTTGNCCTAGWTYYG.
RGL1 geneGeneProductENSG00000143344 (Ensembl)
RGL1ProteinQ9NZL6 (Uniprot-TrEMBL)
RGZ MetaboliteCHEBI:50122 (ChEBI)
RORA ProteinP35398 (Uniprot-TrEMBL)
RORA:CoactivatorComplexR-HSA-1368124 (Reactome)
RXRA ProteinP19793 (Uniprot-TrEMBL)
RXRAProteinP19793 (Uniprot-TrEMBL)
SIN3A ProteinQ96ST3 (Uniprot-TrEMBL)
SIN3B-1 ProteinO75182-1 (Uniprot-TrEMBL)
SLC27A1 geneGeneProductENSG00000130304 (Ensembl)
SLC27A1ProteinQ6PCB7 (Uniprot-TrEMBL)
SMARCD3 ProteinQ6STE5 (Uniprot-TrEMBL)
SP1 ProteinP08047 (Uniprot-TrEMBL)
SREBF1-1(1-490) ProteinP36956-1 (Uniprot-TrEMBL)
SREBF1-3 ProteinP36956-3 (Uniprot-TrEMBL)
SREBF2(1-484) ProteinQ12772 (Uniprot-TrEMBL)
SREBP1A,1C,2:NF-Y:HMGCS1 geneComplexR-HSA-2426129 (Reactome)
SREBP1A,1C,2:NF-Y:SP1:FDFT1 geneComplexR-HSA-2426135 (Reactome)
SREBP1A,2:NF-Y:HMGCR geneComplexR-HSA-2426128 (Reactome)
SULT2A1 geneGeneProductENSG00000105398 (Ensembl)
SULT2A1ProteinQ06520 (Uniprot-TrEMBL)
TBL1X ProteinO60907 (Uniprot-TrEMBL)
TBL1XProteinO60907 (Uniprot-TrEMBL)
TBL1XR1 ProteinQ9BZK7 (Uniprot-TrEMBL)
TBL1XR1ProteinQ9BZK7 (Uniprot-TrEMBL)
TEAD1 ProteinP28347 (Uniprot-TrEMBL)
TEAD2 ProteinQ15562 (Uniprot-TrEMBL)
TEAD3 ProteinQ99594 (Uniprot-TrEMBL)
TEAD4 ProteinQ15561 (Uniprot-TrEMBL)
TEAD:WWTR1(TAZ)ComplexR-HSA-2032762 (Reactome)
TEAD:YAP1ComplexR-HSA-2032772 (Reactome)
TGS1 ProteinQ96RS0 (Uniprot-TrEMBL)
TIAM2 geneGeneProductENSG00000146426 (Ensembl)
TIAM2ProteinQ8IVF5 (Uniprot-TrEMBL)
TNFRSF21 geneGeneProductENSG00000146072 (Ensembl)
TNFRSF21ProteinO75509 (Uniprot-TrEMBL)
TRIB3 geneGeneProductENSG00000101255 (Ensembl)
TRIB3ProteinQ96RU7 (Uniprot-TrEMBL)
TXNRD1 geneGeneProductENSG00000198431 (Ensembl)
TXNRD1ProteinQ16881 (Uniprot-TrEMBL)
UGT1A9 geneGeneProductENSG00000241119 (Ensembl)
UGT1A9ProteinO60656 (Uniprot-TrEMBL)
WWTR1 ProteinQ9GZV5 (Uniprot-TrEMBL)
YAP1 ProteinP46937 (Uniprot-TrEMBL)
ferriheme b MetaboliteCHEBI:36144 (ChEBI)
p-BMAL1:p-CLOCK,NPAS2ComplexR-HSA-421315 (Reactome)
p-S-ARNTL ProteinO00327 (Uniprot-TrEMBL)
p-S-CLOCK ProteinO15516 (Uniprot-TrEMBL)
p-S-NPAS2 ProteinQ99743 (Uniprot-TrEMBL)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
4xPalmC-CD36ArrowR-HSA-560517 (Reactome)
ABCA1 geneR-HSA-1989765 (Reactome)
ABCA1ArrowR-HSA-1989765 (Reactome)
ABCB4 geneR-HSA-1989762 (Reactome)
ABCB4ArrowR-HSA-1989762 (Reactome)
ACADM geneR-HSA-1989745 (Reactome)
ACADMArrowR-HSA-1989745 (Reactome)
ACOX1 geneR-HSA-1989749 (Reactome)
ACOX1-1ArrowR-HSA-1989749 (Reactome)
ACSL1 geneR-HSA-1989778 (Reactome)
ACSL1ArrowR-HSA-1989778 (Reactome)
AGT geneR-HSA-1989774 (Reactome)
AGTArrowR-HSA-1989774 (Reactome)
ALAS1 geneR-HSA-1592238 (Reactome)
ALAS1ArrowR-HSA-1592238 (Reactome)
ANGPTL geneR-HSA-560473 (Reactome)
ANGPTL4ArrowR-HSA-560473 (Reactome)
ANKRD1 geneR-HSA-1989779 (Reactome)
ANKRD1ArrowR-HSA-1989779 (Reactome)
APOA1 geneR-HSA-1989754 (Reactome)
APOA1(25-266)ArrowR-HSA-1989754 (Reactome)
APOA2 geneR-HSA-1989776 (Reactome)
APOA2(24-100)ArrowR-HSA-1989776 (Reactome)
APOA5 geneR-HSA-1989761 (Reactome)
APOA5ArrowR-HSA-1989761 (Reactome)
ArrowR-HSA-1368065 (Reactome)
ArrowR-HSA-1592238 (Reactome)
ArrowR-HSA-1801587 (Reactome)
ArrowR-HSA-879724 (Reactome)
CD36 geneR-HSA-560517 (Reactome)
CPT1A geneR-HSA-1801587 (Reactome)
CPT1AArrowR-HSA-1801587 (Reactome)
CPT2ArrowR-HSA-1989773 (Reactome)
CPT2R-HSA-1989773 (Reactome)
CTGF geneR-HSA-1989766 (Reactome)
CTGFArrowR-HSA-1989766 (Reactome)
CYP1A1 geneR-HSA-1989764 (Reactome)
CYP1A1ArrowR-HSA-1989764 (Reactome)
CYP4A11 geneR-HSA-1989755 (Reactome)
CYP4A11ArrowR-HSA-1989755 (Reactome)
CYP7A1 geneR-HSA-1989746 (Reactome)
CYP7A1ArrowR-HSA-1989746 (Reactome)
Coactivators of PPARalphaR-HSA-400143 (Reactome)
Corepressors of PPARalphaArrowR-HSA-400143 (Reactome)
Corepressors of PPARalphaR-HSA-400183 (Reactome)
FABP1 geneR-HSA-1989751 (Reactome)
FABP1:ligands of PPARAR-HSA-400143 (Reactome)
FABP1ArrowR-HSA-1989751 (Reactome)
FABP1ArrowR-HSA-400143 (Reactome)
FADS1 geneR-HSA-1989757 (Reactome)
FADS1ArrowR-HSA-1989757 (Reactome)
FDFT1 geneR-HSA-1655850 (Reactome)
FDFT1ArrowR-HSA-1655850 (Reactome)
FHL2 geneR-HSA-1989747 (Reactome)
FHL2ArrowR-HSA-1989747 (Reactome)
G0S2 geneR-HSA-1989759 (Reactome)
G0S2ArrowR-HSA-1989759 (Reactome)
GLIPR1 geneR-HSA-1989772 (Reactome)
GLIPR1ArrowR-HSA-1989772 (Reactome)
GRHL1 geneR-HSA-1989748 (Reactome)
GRHL1ArrowR-HSA-1989748 (Reactome)
HMGCR geneR-HSA-1655826 (Reactome)
HMGCR-1ArrowR-HSA-1655826 (Reactome)
HMGCS1 geneR-HSA-1655848 (Reactome)
HMGCS1ArrowR-HSA-1655848 (Reactome)
HMGCS2 geneR-HSA-1989760 (Reactome)
HMGCS2ArrowR-HSA-1989760 (Reactome)
ME1 geneR-HSA-1989756 (Reactome)
ME1ArrowR-HSA-1989756 (Reactome)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHATBarR-HSA-1989746 (Reactome)
NPAS2 geneR-HSA-1368065 (Reactome)
NPAS2ArrowR-HSA-1368065 (Reactome)
NR1D1 (REV-ERBA):heme:CorepressorTBarR-HSA-1368065 (Reactome)
PEX11A geneR-HSA-1989753 (Reactome)
PEX11AArrowR-HSA-1989753 (Reactome)
PLIN2 geneR-HSA-1989770 (Reactome)
PLIN2ArrowR-HSA-1989770 (Reactome)
PPARA geneR-HSA-879724 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1368065 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1592238 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1655826 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1655848 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1655850 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1801587 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989745 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989746 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989747 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989748 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989749 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989750 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989751 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989752 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989753 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989754 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989755 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989756 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989757 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989758 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989759 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989760 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989761 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989762 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989764 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989765 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989766 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989767 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989768 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989770 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989771 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989772 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989773 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989774 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989775 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989776 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989777 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989778 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989779 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-400143 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-560473 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-560517 (Reactome)
PPARA:RXRA Corepressor complexArrowR-HSA-400183 (Reactome)
PPARA:RXRA Corepressor complexR-HSA-400143 (Reactome)
PPARA:RXRA heterodimerArrowR-HSA-400204 (Reactome)
PPARA:RXRA heterodimerR-HSA-400183 (Reactome)
PPARAArrowR-HSA-879724 (Reactome)
PPARAR-HSA-400204 (Reactome)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator ComplexArrowR-HSA-560473 (Reactome)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator ComplexArrowR-HSA-560517 (Reactome)
Peroxisome

Proliferator Receptor Element

(PPRE)		R-HSA-400204 (Reactome)
R-HSA-1368065 (Reactome) The NPAS2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein. Transcription of NPAS2 is enhanced by the RORA:Coactivator complex and repressed by the REV-ERBA:Corepressor complex.
R-HSA-1592238 (Reactome) The ALAS1 gene is transcribed to yield mRNA and the mRNA is translated in the cytosol to yield precursor protein. The ALAS1 precursor is imported into the mitochodrial matrix where it catalyzes the synthesis of 5-aminolevulinate from glycine and succinyl-CoA as part of heme biosynthesis.
R-HSA-1655826 (Reactome) The HMGCR gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655848 (Reactome) The HMGCS1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655850 (Reactome) The FDFT1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1801587 (Reactome) The CPT1A gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989745 (Reactome) The ACADM gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989746 (Reactome) The CYP7A1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989747 (Reactome) The FHL2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989748 (Reactome) The GRHL1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989749 (Reactome) The ACOX1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989750 (Reactome) The FATP1 (SLC27A1) gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989751 (Reactome) The FABP1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989752 (Reactome) The TXNRD1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989753 (Reactome) The PEX11A gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989754 (Reactome) The APOA1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989755 (Reactome) The CYP4A11 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989756 (Reactome) The ME1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989757 (Reactome) The FADS1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989758 (Reactome) The UGT1A9 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989759 (Reactome) The G0S2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989760 (Reactome) The HMGCS2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989761 (Reactome) The APOA5 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989762 (Reactome) The ABCB4 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989764 (Reactome) The CYP1A1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989765 (Reactome) The ABCA1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989766 (Reactome) The CTGF gene is transcribed to yield mRNA and the mRNA is translated to yield protein. Transcription of the CTGF gene is increased by both YAP1:TEAD and WWTR1(TAZ):TEAD transcriptional coactivator:transcription factor complexes, so that CTFG is one of the many genes whose expression is downregulated by the action of the hippo cascade (Zhang et al. 2009; Zhao et al. 2008).
R-HSA-1989767 (Reactome) The TRIB3 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989768 (Reactome) The TIAM2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989770 (Reactome) The Adipophilin (PLIN2) gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989771 (Reactome) The TNFRSF21 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989772 (Reactome) The GLIPR1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989773 (Reactome) The CPT2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989774 (Reactome) The AGT gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989775 (Reactome) The SULT2A1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989776 (Reactome) The APOA2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989777 (Reactome) The RGL1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989778 (Reactome) The ACSL1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989779 (Reactome) The ANKRD1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-400143 (Reactome) PPAR-alpha is activated by binding polyunsaturated fatty acids especially those having 18-22 carbon groups and 2-6 double bonds. These ligands bind the C-terminal region of PPAR-alpha and include linoleic acid, linolenic acids, arachidonic acid, and eicosapentaenoic acid. The fibrate drugs are also agonists of PPAR-alpha.
Binding of a ligand causes a conformational change in PPAR-alpha so that it recruits coactivators. By analogy with the closely related receptor PPAR-gamma, PPAR-alpha probably binds TBL1 and TBLR1, which are responsible for recruiting the 19S proteasome to degrade corepressors during the exchange of corepressors for coactivators. The coactivators belong to the CBP-SRC-HAT complex (CBP/p300, SRC1, SRC2, SRC3, CARM1, SWI/SNF, BAF60C, PRIC320, and PRIC285), the ASC complex (PRIP/ASC2, PIMT), and the TRAP-DRIP-ARC-MEDIATOR complex (TRAP130, PBP/TRAP220). The coactivators contain LXXLL motifs (Nuclear Receptor Boxes) that interact with the AF-2 region in nuclear receptors such as PPAR-alpha.
R-HSA-400183 (Reactome) In the absence of activating ligands of PPAR-alpha, the PPAR-alpha:RXR-alpha heterodimers recruit corepressors NCoR1, NCoR2(SMRT), and histone deacetylases (HDACs) to genes regulated by PPAR-alpha. The corepressors maintain chromatin at the gene in an inactive conformation and prevent expression of the gene.
R-HSA-400204 (Reactome) Peroxisome proliferator-activated receptor alpha (PPAR-alpha) is a type II nuclear receptor (its subcellular location is independent of ligand binding) related to PPAR-beta/delta and PPAR-gamma. PPAR-alpha is expressed highly in the liver where if functions to control lipid metabolism, especially fatty acid oxidation.
PPAR-alpha forms heterodimers with Retinoid X receptor alpha (RXR-alpha). The heterodimers bind peroxisome proliferator receptor elements (PPREs) in and around genes regulated by PPAR-alpha.
R-HSA-560473 (Reactome) The ANGPTL4 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-560517 (Reactome) The Platelet glycoprotein IV gene (CD36, PAS IV, GPIV) is transcribed to yield mRNA and the mRNA is translated to yield proteind.
R-HSA-879724 (Reactome) The PPARA gene is transcribed to yield mRNA and the mRNA is translated to yield protein. As inferred from mouse, BMAL1:CLOCK (ARNTL:CLOCK) heterodimers bind the scond intron of the PPARA gene and activate transcription of PPARA.
RGL1 geneR-HSA-1989777 (Reactome)
RGL1ArrowR-HSA-1989777 (Reactome)
RXRAR-HSA-400204 (Reactome)
SLC27A1 geneR-HSA-1989750 (Reactome)
SLC27A1ArrowR-HSA-1989750 (Reactome)
SREBP1A,1C,2:NF-Y:HMGCS1 geneArrowR-HSA-1655848 (Reactome)
SREBP1A,1C,2:NF-Y:SP1:FDFT1 geneArrowR-HSA-1655850 (Reactome)
SREBP1A,2:NF-Y:HMGCR geneArrowR-HSA-1655826 (Reactome)
SULT2A1 geneR-HSA-1989775 (Reactome)
SULT2A1ArrowR-HSA-1989775 (Reactome)
TBL1XR-HSA-400183 (Reactome)
TBL1XR1R-HSA-400183 (Reactome)
TEAD:WWTR1(TAZ)ArrowR-HSA-1989766 (Reactome)
TEAD:YAP1ArrowR-HSA-1989766 (Reactome)
TIAM2 geneR-HSA-1989768 (Reactome)
TIAM2ArrowR-HSA-1989768 (Reactome)
TNFRSF21 geneR-HSA-1989771 (Reactome)
TNFRSF21ArrowR-HSA-1989771 (Reactome)
TRIB3 geneR-HSA-1989767 (Reactome)
TRIB3ArrowR-HSA-1989767 (Reactome)
TXNRD1 geneR-HSA-1989752 (Reactome)
TXNRD1ArrowR-HSA-1989752 (Reactome)
UGT1A9 geneR-HSA-1989758 (Reactome)
UGT1A9ArrowR-HSA-1989758 (Reactome)
p-BMAL1:p-CLOCK,NPAS2ArrowR-HSA-879724 (Reactome)
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