Cargo concentration in the ER (Homo sapiens)

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5-7, 12-15, 17...2-4, 10, 169, 11, 17171, 8cytosolendoplasmic reticulum lumenFactor VIII precursor LMAN2 3x4Hyp-3Hyp-COL7A1 3x4Hyp-COL7A1 SEC24B GTP COPIIcargoreceptors:SAR1B:GTP:SEC23:SEC245Hyl-COL7A1 LMAN1L CNIH2,3:GRIA13x4Hyp-3Hyp-GalHyl-COL7A1 GPI-CD59 LMAN1 LMAN2L LMAN1 GlcGalHyl-COL7A1 procollagenVII:SEC24C:SEC23ALMAN1L 3x4Hyp-3Hyp-COL7A1 3x4Hyp-5Hyl-COL7A1 3x4Hyp-3Hyp-COL7A1 3x4Hyp-5Hyl-COL7A1 GPI-FOLR1 3x4Hyp-GlcGalHyl-COL7A1 GPI-FOLR1 SEC24D 3x4Hyp-COL7A1 3x4Hyp-3Hyp-GlcGalHyl-COL7A1 COL7A1 PREB CNIH2 3x4Hyp-GalHyl-COL7A1 TGFA precursor SEC24D STX5 nascent procollagen VII vesicle SEC23A 3x4Hyp-GlcGalHyl-COL7A1 3x4Hyp-3Hyp-5Hyl-COL7A1 PREB 3x4Hyp-COL7A1 TMED2 CNIH1 LMAN1:MCFD2:glycosylated FV, FVIII precursorGPI-CD59, GPI-FOLR13x4Hyp-3Hyp-GalHyl-COL7A1 GalHyl-COL7A1 3x4Hyp-5Hyl-COL7A1 CTAGE5:PREB5Hyl-COL7A1 COL7A1 TMED2 GlcGalHyl-COL7A1 GOSR2 LMAN2 PREBGlcGalHyl-COL7A1 GOSR2 3x4Hyp-GalHyl-COL7A1 COPIIcargo:receptors5Hyl-COL7A1 3x4Hyp-3Hyp-GalHyl-COL7A1 5Hyl-COL7A1 MCFD2 5Hyl-COL7A1 Factor VIII precursor COPII (Coat Protein2) Mediated VesicleTransportCTAGE5 SEC24B Factor V precursor SEC23A 3x4Hyp-3Hyp-COL7A1 COL7A1 SEC24B SEC23A (Glc)3(GlcNAc)2(Man)9-SERPINA1 LMAN2 TGFA precursor TMED2 glycosylated FV,FVIII precursorSEC24A,B:SEC23A:SEC22BSEC24C CNIH1TMED10 SEC24A SAR1B 3x4Hyp-3Hyp-5Hyl-COL7A1 TMED2 GRIA1 3x4Hyp-3Hyp-GlcGalHyl-COL7A1 3x4Hyp-5Hyl-COL7A1 3x4Hyp-3Hyp-GalHyl-COL7A1 SEC24D LMAN1 SEC23A 3x4Hyp-GalHyl-COL7A1 3x4Hyp-3Hyp-GlcGalHyl-COL7A1 SEC24CGalHyl-COL7A1 SEC24C GPI-CD59 Procollagen type VIInascent procollagen VII vesicle TMED10 SEC24C 3x4Hyp-5Hyl-COL7A1 3x4Hyp-3Hyp-5Hyl-COL7A1 3x4Hyp-COL7A1 (Glc)3(GlcNAc)2(Man)9-CTSZ LMAN2L CTAGE5:MIA3(Glc)3(GlcNAc)2(Man)9-CTSC SEC24C,DGalHyl-COL7A1 CNIH2 5Hyl-COL7A1 (Glc)3(GlcNAc)2(Man)9-SERPINA1 3x4Hyp-COL7A1 Factor V precursor 3x4Hyp-GlcGalHyl-COL7A1 3x4Hyp-3Hyp-5Hyl-COL7A1 SEC23A 3x4Hyp-3Hyp-GalHyl-COL7A1 LMAN2 (Glc)3(GlcNAc)2(Man)9-SERPINA1 STX5 SEC23A:SEC24C,D:GOSR2,STX5SEC24D LMAN1L AREG precursor 3x4Hyp-3Hyp-GlcGalHyl-COL7A1 SEC24C CTAGE5 (Glc)3(GlcNAc)2(Man)9-CTSZ Factor V precursor CNIH1 LMAN2L GlcGalHyl-COL7A1 LMAN familyreceptorsTMED2:TMED10tetramerFactor VIII precursor GlcGalHyl-COL7A1 nascent procollagen VII vesicle GTP TGFA precursor 3x4Hyp-COL7A1 3x4Hyp-5Hyl-COL7A1 SEC22B3x4Hyp-GalHyl-COL7A1 GlcGalHyl-COL7A1 MCFD2 3x4Hyp-GlcGalHyl-COL7A1 SEC24C GalHyl-COL7A1 CNIH1:TFGA,AREGprecursorsSEC24C CTAGE5GPI-CD59 CNIH1 GRIA1 LMAN1 MIA3 Glycoproteins with Man8 N-glycans COL7A1 SEC23A TGFA precursor GRIA1 GPI-FOLR1 SEC23A Glycoproteins with Man8 N-glycans Glycoproteins with Man8 N-glycans GPI-FOLR1 AREG precursor 3x4Hyp-GalHyl-COL7A1 CTAGE5 3x4Hyp-GalHyl-COL7A1 SEC24A 3x4Hyp-3Hyp-GlcGalHyl-COL7A1 MCFD2 SEC24C CNIH2,3SEC23A Factor VIII precursor SEC23:SEC24TMED2:TMED10tetramer:GPI-CD59,GPI-FOLR1Factor V precursor MIA3MIA3 LMAN1 GRIA1LMAN1 GPI-CD59 SAR1B AREG precursor (Glc)3(GlcNAc)2(Man)9-CTSZ GOSR2,STX53x4Hyp-3Hyp-GalHyl-COL7A1 procollagenVII:MIA3:CTAGE5:PREB:SEC23A:SEC24ChexamericLMAN1:MCFD2LMANreceptor:glycosylated cargoGalHyl-COL7A1 GOSR2 SEC23A 3x4Hyp-3Hyp-5Hyl-COL7A1 SEC24D 3x4Hyp-3Hyp-5Hyl-COL7A1 GOSR2 SEC24D GalHyl-COL7A1 LMAN1 SEC22B (Glc)3(GlcNAc)2(Man)9-CTSC 3x4Hyp-GlcGalHyl-COL7A1 (Glc)3(GlcNAc)2(Man)9-CTSC glycosylated LMANcargoCOL7A1 3x4Hyp-3Hyp-COL7A1 SEC24B Glycoproteins with Man8 N-glycans 3x4Hyp-GlcGalHyl-COL7A1 TMED10 3x4Hyp-3Hyp-COL7A1 (Glc)3(GlcNAc)2(Man)9-CTSC STX5 AREG precursor CNIH3 SEC23ACNIH2 (Glc)3(GlcNAc)2(Man)9-SERPINA1 TFGA, AREGprecursorsSTX5 LMAN2L (Glc)3(GlcNAc)2(Man)9-CTSZ CNIH3 CNIH3 3x4Hyp-3Hyp-GlcGalHyl-COL7A1 LMAN1 MCFD2 SEC24C CNIH3 SEC24C TMED10 Procollagen typeVII:MIA3COL7A1 SEC24A MIA3 CNIH2 SEC24A LMAN1L SAR1B:GTPSEC24A,SEC24B


Description

Computational analysis suggests that ~25% of the proteome may be exported from the ER in human cells (Kanapin et al, 2003). These cargo need to be recognized and concentrated into COPII vesicles, which range in size from 60-90 nm, and which move cargo from the ER to the ERGIC in mammalian cells (reviewed in Lord et al, 2013; Szul and Sztul, 2011). Recognition of transmembrane cargo is mediated by interaction with one of the 4 isoforms of SEC24, a component of the inner COPII coat (Miller et al, 2002; Miller et al, 2003; Mossessova et al, 2003; Mancias and Goldberg, 2008). Soluble cargo in the ER lumen is concentrated into COPII vesicles through interaction with a receptor of the ERGIC-53 family, the p24 family or the ERV family. Each of these families of transmembrane receptors interact with cargo through their lumenal domains and with components of the COPII coat with their cytoplasmic domains and are packaged into the COPII vesicle along with the cargo. The receptors are subsequently recycled to the ER in COPI vesicles through retrograde traffic (reviewed in Dancourt and Barlowe, 2010). Packaging of large cargo such as fibrillar collagen depends on the transmembrane accessory factors MIA3 (also known as TANGO1) and CTAGE5. Like the ERGIC, p24 and ERV cargo receptors, MIA3 and CTAGE5 interact both with the collagen cargo and with components of the COPII coat. Unlike the other cargo receptors, however, MIA3 and CTAGE5 are not loaded into the vesicle but remain in the ER membrane (reviewed in Malhotra and Erlmann, 2011; Malhotra et al, 2015). View original pathway at:Reactome.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
114775view16:26, 25 January 2021ReactomeTeamReactome version 75
113219view11:28, 2 November 2020ReactomeTeamReactome version 74
112443view15:39, 9 October 2020ReactomeTeamReactome version 73
101348view11:23, 1 November 2018ReactomeTeamreactome version 66
100886view20:57, 31 October 2018ReactomeTeamreactome version 65
100427view19:31, 31 October 2018ReactomeTeamreactome version 64
99977view16:15, 31 October 2018ReactomeTeamreactome version 63
99531view14:51, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99169view12:42, 31 October 2018ReactomeTeamreactome version 62
93964view13:48, 16 August 2017ReactomeTeamreactome version 61
93560view11:27, 9 August 2017ReactomeTeamreactome version 61
87156view19:12, 18 July 2016MkutmonOntology Term : 'transport pathway' added !
86663view09:23, 11 July 2016ReactomeTeamreactome version 56
83450view12:26, 18 November 2015ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(Glc)3(GlcNAc)2(Man)9-CTSC ProteinP53634 (Uniprot-TrEMBL)
(Glc)3(GlcNAc)2(Man)9-CTSZ ProteinQ9UBR2 (Uniprot-TrEMBL)
(Glc)3(GlcNAc)2(Man)9-SERPINA1 ProteinP01009 (Uniprot-TrEMBL)
3x4Hyp-3Hyp-5Hyl-COL7A1 ProteinQ02388 (Uniprot-TrEMBL)
3x4Hyp-3Hyp-COL7A1 ProteinQ02388 (Uniprot-TrEMBL)
3x4Hyp-3Hyp-GalHyl-COL7A1 ProteinQ02388 (Uniprot-TrEMBL)
3x4Hyp-3Hyp-GlcGalHyl-COL7A1 ProteinQ02388 (Uniprot-TrEMBL)
3x4Hyp-5Hyl-COL7A1 ProteinQ02388 (Uniprot-TrEMBL)
3x4Hyp-COL7A1 ProteinQ02388 (Uniprot-TrEMBL)
3x4Hyp-GalHyl-COL7A1 ProteinQ02388 (Uniprot-TrEMBL)
3x4Hyp-GlcGalHyl-COL7A1 ProteinQ02388 (Uniprot-TrEMBL)
5Hyl-COL7A1 ProteinQ02388 (Uniprot-TrEMBL)
AREG precursor ProteinP15514 (Uniprot-TrEMBL)
CNIH1 ProteinO95406 (Uniprot-TrEMBL)
CNIH1:TFGA,AREG precursorsComplexR-HSA-5694249 (Reactome)
CNIH1ProteinO95406 (Uniprot-TrEMBL)
CNIH2 ProteinQ6PI25 (Uniprot-TrEMBL)
CNIH2,3:GRIA1ComplexR-HSA-5694247 (Reactome)
CNIH2,3ComplexR-HSA-5694240 (Reactome)
CNIH3 ProteinQ8TBE1 (Uniprot-TrEMBL)
COL7A1 ProteinQ02388 (Uniprot-TrEMBL)
COPII

cargo

receptors:SAR1B:GTP:SEC23:SEC24		ComplexR-HSA-5694523 (Reactome)
COPII cargo:receptorsComplexR-HSA-5694244 (Reactome)
COPII (Coat Protein

2) Mediated Vesicle

Transport		PathwayR-HSA-204005 (Reactome) COPII components (known as Sec13p, Sec23p, Sec24p, Sec31p, and Sar1p in yeast) traffic cargo from the endoplasmic reticulum to the ER-Golgi intermediate compartment (ERGIC). COPII-coated vesicles were originally discovered in the yeast Saccharomyces cerevisiae using genetic approaches coupled with a cell-free assay. The mammalian counterpart of this pathway is represented here. Newly synthesized proteins destined for secretion are sorted into COPII-coated vesicles at specialized regions of the ER. These vesicles leave the ER, become uncoated and subsequently fuse with the ERGIC membrane.
CTAGE5 ProteinO15320 (Uniprot-TrEMBL)
CTAGE5:MIA3ComplexR-HSA-5694292 (Reactome)
CTAGE5:PREBComplexR-HSA-5694290 (Reactome)
CTAGE5ProteinO15320 (Uniprot-TrEMBL)
Factor V precursor ProteinP12259 (Uniprot-TrEMBL)
Factor VIII precursor ProteinP00451 (Uniprot-TrEMBL)
GOSR2 ProteinO14653 (Uniprot-TrEMBL)
GOSR2,STX5ComplexR-HSA-5694232 (Reactome)
GPI-CD59 ProteinP13987 (Uniprot-TrEMBL)
GPI-CD59, GPI-FOLR1ComplexR-HSA-5694226 (Reactome)
GPI-FOLR1 ProteinP15328 (Uniprot-TrEMBL)
GRIA1 ProteinP42261 (Uniprot-TrEMBL)
GRIA1ProteinP42261 (Uniprot-TrEMBL)
GTP MetaboliteCHEBI:15996 (ChEBI)
GalHyl-COL7A1 ProteinQ02388 (Uniprot-TrEMBL)
GlcGalHyl-COL7A1 ProteinQ02388 (Uniprot-TrEMBL)
Glycoproteins with Man8 N-glycans R-HSA-5694207 (Reactome)
Glycoproteins with Man8 N-glycans R-HSA-5694224 (Reactome)
LMAN receptor:glycosylated cargoComplexR-HSA-5694248 (Reactome)
LMAN family receptorsComplexR-HSA-5694343 (Reactome)
LMAN1 ProteinP49257 (Uniprot-TrEMBL)
LMAN1:MCFD2:glycosylated FV, FVIII precursorComplexR-HSA-5694243 (Reactome)
LMAN1L ProteinQ9HAT1 (Uniprot-TrEMBL)
LMAN2 ProteinQ12907 (Uniprot-TrEMBL)
LMAN2L ProteinQ9H0V9 (Uniprot-TrEMBL)
MCFD2 ProteinQ8NI22 (Uniprot-TrEMBL)
MIA3 ProteinQ5JRA6 (Uniprot-TrEMBL)
MIA3ProteinQ5JRA6 (Uniprot-TrEMBL)
PREB ProteinQ9HCU5 (Uniprot-TrEMBL)
PREBProteinQ9HCU5 (Uniprot-TrEMBL)
Procollagen type VII:MIA3ComplexR-HSA-5694291 (Reactome)
Procollagen type VIIComplexR-HSA-2060923 (Reactome)
SAR1B ProteinQ9Y6B6 (Uniprot-TrEMBL)
SAR1B:GTPComplexR-HSA-204003 (Reactome)
SEC22B ProteinO75396 (Uniprot-TrEMBL)
SEC22BProteinO75396 (Uniprot-TrEMBL)
SEC23:SEC24ComplexR-HSA-203975 (Reactome)
SEC23A ProteinQ15436 (Uniprot-TrEMBL)
SEC23A:SEC24C,D:GOSR2,STX5ComplexR-HSA-5694245 (Reactome)
SEC23AProteinQ15436 (Uniprot-TrEMBL)
SEC24A ProteinO95486 (Uniprot-TrEMBL)
SEC24A,B:SEC23A:SEC22BComplexR-HSA-5694319 (Reactome)
SEC24A,SEC24BComplexR-HSA-5694203 (Reactome)
SEC24B ProteinO95487 (Uniprot-TrEMBL)
SEC24C ProteinP53992 (Uniprot-TrEMBL)
SEC24C,DComplexR-HSA-5694201 (Reactome)
SEC24CProteinP53992 (Uniprot-TrEMBL)
SEC24D ProteinO94855 (Uniprot-TrEMBL)
STX5 ProteinQ13190 (Uniprot-TrEMBL)
TFGA, AREG precursorsComplexR-HSA-5694195 (Reactome)
TGFA precursor ProteinP01135 (Uniprot-TrEMBL)
TMED10 ProteinP49755 (Uniprot-TrEMBL)
TMED2 ProteinQ15363 (Uniprot-TrEMBL)
TMED2:TMED10

tetramer:GPI-CD59,

GPI-FOLR1		ComplexR-HSA-5694246 (Reactome)
TMED2:TMED10 tetramerComplexR-HSA-5694237 (Reactome)
glycosylated FV, FVIII precursorComplexR-HSA-5694189 (Reactome)
glycosylated LMAN cargoComplexR-HSA-5694340 (Reactome)
hexameric LMAN1:MCFD2ComplexR-HSA-5694241 (Reactome)
nascent procollagen VII vesicle R-NUL-5694171 (Reactome)
procollagen VII:MIA3:CTAGE5:PREB:SEC23A:SEC24CComplexR-HSA-5694288 (Reactome)
procollagen VII:SEC24C:SEC23AComplexR-HSA-5694250 (Reactome)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
CNIH1:TFGA,AREG precursorsArrowR-HSA-5694445 (Reactome)
CNIH1R-HSA-5694445 (Reactome)
CNIH2,3:GRIA1ArrowR-HSA-5694442 (Reactome)
CNIH2,3R-HSA-5694442 (Reactome)
COPII

cargo

receptors:SAR1B:GTP:SEC23:SEC24		ArrowR-HSA-5694522 (Reactome)
COPII cargo:receptorsR-HSA-5694522 (Reactome)
CTAGE5:MIA3ArrowR-HSA-5694436 (Reactome)
CTAGE5:PREBArrowR-HSA-5694433 (Reactome)
CTAGE5:PREBR-HSA-5694435 (Reactome)
CTAGE5R-HSA-5694433 (Reactome)
GOSR2,STX5R-HSA-5694413 (Reactome)
GPI-CD59, GPI-FOLR1R-HSA-5694410 (Reactome)
GRIA1R-HSA-5694442 (Reactome)
LMAN receptor:glycosylated cargoArrowR-HSA-5694428 (Reactome)
LMAN family receptorsR-HSA-5694428 (Reactome)
LMAN1:MCFD2:glycosylated FV, FVIII precursorArrowR-HSA-5694431 (Reactome)
MIA3R-HSA-5694427 (Reactome)
PREBArrowR-HSA-5694436 (Reactome)
PREBR-HSA-5694433 (Reactome)
Procollagen type VII:MIA3ArrowR-HSA-5694427 (Reactome)
Procollagen type VII:MIA3R-HSA-5694435 (Reactome)
Procollagen type VIIR-HSA-5694427 (Reactome)
R-HSA-5694410 (Reactome) TMED2 and TMED10 are members of the p24 family of proteins that bind GPI anchored proteins in the ER and mediate their incorporation into COPII vesicles (Bonnon et al, 2010; reviewed in Strating et al, 2009). p24 proteins function as heteromeric complexes and interact with components of the COPII coat (Jenne et al, 2002; Dominguez et al, 1998; reviewed in Strating et al, 2009). In complex with LMAN1 and SURF4, they also play a role in maintaining the structure of the ERGIC (Mitrovic et al, 2008).
R-HSA-5694413 (Reactome) SEC24 isoforms C and D are required in conjunction with SEC23A for packaging the t-SNARES STX5 and GOSR2 into COPII vesicles for transport to the Golgi (Mancias and Goldberg, 2008).
R-HSA-5694415 (Reactome) Of the four human SEC24 isoforms, SEC24A and B are required for packaging the v-SNARE SEC22 into COPII vesicles. Recognition of the ER packaging epitope on SEC22 also depends on SEC23A (Mancias and Goldberg, 2007).
R-HSA-5694427 (Reactome) Procollagen VII trimers, which are too large for standard COPII vesicles, are packaged into larger transport vesicles through interaction with the transmembrane accessory proteins MIA3 (also known as TANGO1) and CTAGE5. MIA3 interacts with collagen through its lumenal SH3 domain and interacts with SEC23 and SEC24 through the proline rich domain (Saito et al, 2009; reviewed in Malhotra and Erlmann, 2011; Malhotra et al, 2015).
R-HSA-5694428 (Reactome) LMAN1, also known as ERGIC-53, is a transmembrane receptor that binds to high-mannose containing soluble glycoproteins in the ER and helps package them into COPII vesicles for trafficking to the ERGIC and Golgi. Identified cargo include SERPINA (alpha1-antitrypsin) and the cathepsins CTSC and CTSZ, among others (Nyefeler et al, 2008; Appenzeller et al, 1999; reviewed in Hauri et al, 2000; Szul and Sztul, 2011). LMAN1 itself is concentrated into COPII vesicles through interaction with components of the COPII coat (Kappeler et al, 1997; reviewed in Dancourt and Barlowe, 2010). Other LMAN family proteins, which include LMANL1, LMAN2 and LMAN2L, also bind glycosylated ER cargo proteins, although the lectin specificities vary (Kamiya et al, 2005; Kamiya et al, 2007; Reiterer et al, 2010; reviewed in Dancourt and Barlowe, 2010).
R-HSA-5694431 (Reactome) Secretion of the clotting factor precursors Factor V and Factor VIII from the ER depends on interaction with a Ca2+-dependent receptor complex of LMAN1 and its soluble interaction partner MCFD2 (Nyfeler et al, 2006; reviewed in Zheng and Zhang, 2013; Dancourt and Barlowe, 2010).
R-HSA-5694433 (Reactome) CTAGE5, a transmembrane ER protein with roles in collagen secretion, recruits the SAR1 GEF PREB (also known as SEC12) to ER exit sites (Saito et al, 2014).
R-HSA-5694435 (Reactome) CTAGE5 and MIA3 form heterodimers through their second coiled coil domains and interact with inner coat proteins SEC24C and SEC23A through their proline-rich domains. In this way, the MIA3 and CTAGE5 concentrate procollagen VII at ER exit sites (Saito et al, 2011; reviewed in Malhotra and Erlmann, 2011; Malhotra et al, 2015).
R-HSA-5694436 (Reactome) Unlike other cargo receptors, CTAGE5 and MIA3 are not packaged into COPII vesicles but remain behind in the ER membrane. Dissociation of MIA3 from procollagen and from inner coat proteins SEC23 and SEC24 is thought to trigger recruitment of the outer coat proteins SEC13/31, allowing COPII coat maturation (Saito et al, 2009; Saito et al, 2011; reviewed in Malhotra and Erlmann, 2011; Malhotra et al, 2015).
R-HSA-5694442 (Reactome) CNIH2 and 3 are members of the ERV14 family of transmembrane proteins with a role in chaperoning cargo out of the ER (reviewed in Dancourt and Barlowe, 2010). CNIH2 and 3 bind to components of the AMPA-type glutamate receptor complex, including GRIA1 in the ER and facilitate their trafficking to the plasma membrane. CNIH2 and 3 may play additional roles at the cell surface modulating the function of the channels (Shi et al, 2010; Schwenk et al, 2009).
R-HSA-5694445 (Reactome) CNIH1, also known as ERV14, is a member of the ERV family of proteins that act as cargo receptors for ER-to-ERGIC trafficking (reviewed in Dancourt and Barlowe, 2010). CNIH1 preferentially interacts with transmembrane proteins like the precursor forms of TFGA and AREG, and mediates their packaging into COPII vesicles by interacting with components of the COPII coat (Castro et al, 2007).
R-HSA-5694522 (Reactome) SAR1:GTP recruits the cytoplasmic SEC23:SEC24 complex. SEC24, and to a lesser extent SEC23, also mediate interaction with COPII cargo, concentrating it into the emerging vesicle. Transmembrane cargo may interact directly with the inner coat proteins, often in an isoform specific manner; alternately, some transmembrane proteins and all soluble cargo interact first with a cargo receptor of the p24, LMAN or ERV families.
SAR1B:GTPR-HSA-5694522 (Reactome)
SEC22BR-HSA-5694415 (Reactome)
SEC23:SEC24R-HSA-5694522 (Reactome)
SEC23A:SEC24C,D:GOSR2,STX5ArrowR-HSA-5694413 (Reactome)
SEC23AR-HSA-5694413 (Reactome)
SEC23AR-HSA-5694415 (Reactome)
SEC23AR-HSA-5694435 (Reactome)
SEC24A,B:SEC23A:SEC22BArrowR-HSA-5694415 (Reactome)
SEC24A,SEC24BR-HSA-5694415 (Reactome)
SEC24C,DR-HSA-5694413 (Reactome)
SEC24CR-HSA-5694435 (Reactome)
TFGA, AREG precursorsR-HSA-5694445 (Reactome)
TMED2:TMED10

tetramer:GPI-CD59,

GPI-FOLR1		ArrowR-HSA-5694410 (Reactome)
TMED2:TMED10 tetramerR-HSA-5694410 (Reactome)
glycosylated FV, FVIII precursorR-HSA-5694431 (Reactome)
glycosylated LMAN cargoR-HSA-5694428 (Reactome)
hexameric LMAN1:MCFD2R-HSA-5694431 (Reactome)
procollagen VII:MIA3:CTAGE5:PREB:SEC23A:SEC24CArrowR-HSA-5694435 (Reactome)
procollagen VII:MIA3:CTAGE5:PREB:SEC23A:SEC24CR-HSA-5694436 (Reactome)
procollagen VII:SEC24C:SEC23AArrowR-HSA-5694436 (Reactome)
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