Demo_complete (Homo sapiens)

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Revision as of 19:52, 30 November 2015 by Khanspers (Talk | contribs)
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1Liver cellPlasmaMevalonateSQLEHMGCRCholesterol esterCholesterolFDFT1SOAT1SqualeneHMG-CoAPDIA2StatinMTTPCholesterol ester


Description

Statins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol synthesis. This pathway delineates genes involved in statin pharmacogenomics.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Wetterau JR, Lin MC, Jamil H; ''Microsomal triglyceride transfer protein.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
106736view13:21, 17 September 2019MaintBotHMDB identifier normalization
85855view23:00, 17 June 2016KhanspersModified description
83620view19:55, 30 November 2015KhanspersModified description
83619view19:54, 30 November 2015KhanspersModified description
83618view19:53, 30 November 2015KhanspersModified description
83617view19:52, 30 November 2015KhanspersModified description
83616view19:51, 30 November 2015KhanspersModified description
83615view19:49, 30 November 2015KhanspersModified description
83614view19:48, 30 November 2015KhanspersModified description
82931view17:04, 13 November 2015KhanspersModified title
82346view23:21, 25 September 2015KhanspersAdded transport of cholesterol esters
82345view23:05, 25 September 2015Khanspersredo part 2
82289view22:18, 24 September 2015KhanspersAdded transport of cholesterol ester
82288view21:43, 24 September 2015Khanspersadded cholesterol ester
82287view21:13, 24 September 2015KhanspersAdded additional steps
82286view21:00, 24 September 2015KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Cholesterol esterMetaboliteC02530 (KEGG Compound)
CholesterolMetaboliteHMDB00067 (HMDB)
FDFT1GeneProductENSG00000079459 (Ensembl)
HMG-CoAMetaboliteHMDB01375 (HMDB)
HMGCRGeneProductENSG00000113161 (Ensembl)
MTTPGeneProductENSG00000138823 (Ensembl)
MevalonateMetaboliteHMDB59629 (HMDB)
PDIA2GeneProductENSG00000185615 (Ensembl)
SOAT1GeneProductENSG00000057252 (Ensembl)
SQLEGeneProductENSG00000104549 (Ensembl)
SqualeneMetaboliteHMDB00256 (HMDB)
StatinMetaboliteHMDB05022 (HMDB)

Annotated Interactions

No annotated interactions

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