TCA cycle (streamlined) (Mus musculus)

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CytosolMitochondrionCitrateSdhdMdh2OxaloacetateFumarateDegradation of Fatty Acids Containing an Even Number of CarbonsMdh1Ogdhalpha-KetoglutarateSdhcMalateSuclg1Fh1Idh3gSuclg2SuccinateIsocitrateGluconeogenesisCsSucla2OxaloacetateAco2DldElectron Transport ChainFatty Acid SynthesisSdhaIdh2Acetyl-CoAIdh3aIdh3bDlstMalateSdhbSuccinyl-CoADegradation of Fatty Acids Containing an Even Number of Carbons


Description

This pathway is modified from the TCA Cycle [1] pathway. It adds an entry point for the Glycolysis [2] pathway. The citric acid cycle, also known as the tricarboxylic acid cycle (TCA cycle) or the Krebs cycle, (or rarely, the Szent-Gyorgyi-Krebs cycle) is a series of enzyme-catalysed chemical reactions of central importance in all living cells that use oxygen as part of cellular respiration. In eukaryotes, the citric acid cycle occurs in the matrix of the mitochondrion. The components and reactions of the citric acid cycle were established by seminal work from both Albert Szent-Gyorgyi and Hans Krebs. [From Wikipedia]

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP78(r28870) with a 100% conversion rate.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
118172view10:46, 25 May 2021EweitzModified title
106882view13:35, 17 September 2019MaintBotHMDB identifier normalization
83776view14:48, 4 December 2015GsuModified title
83775view14:47, 4 December 2015GsuModified description
83771view14:29, 4 December 2015GsuModified description
83770view14:26, 4 December 2015GsuNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Acetyl-CoAMetaboliteHMDB01206 (HMDB)
Aco2GeneProduct11429 (Entrez Gene)
CitrateMetaboliteHMDB00094 (HMDB)
CsGeneProduct12974 (Entrez Gene)
Degradation of Fatty Acids Containing an Even Number of CarbonsPathwayWP1269 (WikiPathways)
DldGeneProduct13382 (Entrez Gene)
DlstGeneProduct78920 (Entrez Gene)
Electron Transport ChainPathwayWP295 (WikiPathways)
Fatty Acid SynthesisPathwayWP336 (WikiPathways)
Fh1GeneProduct14194 (Entrez Gene)
FumarateMetaboliteHMDB00134 (HMDB)
GluconeogenesisPathwayWP157 (WikiPathways)
Idh2GeneProduct269951 (Entrez Gene)
Idh3aGeneProduct67834 (Entrez Gene)
Idh3bGeneProduct170718 (Entrez Gene)
Idh3gGeneProduct15929 (Entrez Gene)
IsocitrateMetaboliteHMDB00193 (HMDB)
MalateMetaboliteHMDB00156 (HMDB)
Mdh1GeneProduct17449 (Entrez Gene)
Mdh2GeneProduct17448 (Entrez Gene)
OgdhGeneProduct18293 (Entrez Gene)
OxaloacetateMetaboliteHMDB00223 (HMDB)
SdhaGeneProduct66945 (Entrez Gene)
SdhbGeneProduct67680 (Entrez Gene)
SdhcGeneProduct66052 (Entrez Gene)
SdhdGeneProduct66925 (Entrez Gene)
SuccinateMetaboliteHMDB00254 (HMDB)
Succinyl-CoAMetaboliteHMDB01022 (HMDB)
Sucla2GeneProduct20916 (Entrez Gene)
Suclg1GeneProduct56451 (Entrez Gene)
Suclg2GeneProduct20917 (Entrez Gene)
alpha-KetoglutarateMetabolite

Annotated Interactions

No annotated interactions
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