NAD+ metabolism (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none NucleusL-Tryptophan (TRP)NAMNNADCD38NRNRKNMNNAMPTdATPNMNAT2NADKNADPNADHNMNAT1PRPPCD73FADHNAMPTFADH2ETCTCA CycleGlycolysisPyruvate?NMNAT3PARP1ARTNicotinic acid (NA)TRPNAMNANAMNRNAMNADSIRT1SIRT2NADPHNADNADHNAMNAMPARP1NAMPTNMNNADSIRT1SIRT2SIRT5SIRT6SIRT7NADHNAMNADNADHCytoplasmMitochondriaNMNNADSIRT3SIRT4SIRT5NMNLactateGlyceraldehyde3-phosphateshuttleMalate/aspartate shuttleName: NAD+ metabolismOrganism: Homo sapiens


Description

No description

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View approved pathways at the new wikipathways.org.

Quality Tags

Image:Curated.pngReview changes for Approved
Image:Featured.pngReview changes for Featured
Image:MissingXref.pngAnnotate nodes

Ontology Terms

Pathway Ontology : complement system pathway
 

Bibliography

  1. Verdin E; ''NAD⁺ in aging, metabolism, and neurodegeneration.''; Science, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137776
Approved
view01:03, 8 March 2025KhanspersModified description
118983
Featured
view21:10, 6 June 2021Mkutmonupdate layout
118939view22:30, 4 June 2021EweitzOntology Term : 'nicotinamide adenine dinucleotide metabolic pathway' added !
118786view20:55, 1 June 2021Khanspersupdate metabolites and pathway nodes
115123view19:46, 26 January 2021Khanspersnew layout and style
113960view23:29, 11 December 2020KhanspersModified description
113959view23:27, 11 December 2020KhanspersRemoved question marks in gene symbols, spelled out electron transport chain
112974view18:48, 26 October 2020Khansperslayout and labels
106748view13:23, 17 September 2019MaintBotHMDB identifier normalization
106654view21:16, 12 September 2019KhanspersModified description
105655view05:14, 10 August 2019KhanspersModified description
94904view23:25, 12 October 2017Khanspersadded lit ref
94795view23:19, 5 October 2017AlexanderPicoConnected interactions and fixed catalysis layouts
89859view12:26, 6 October 2016MkutmonModified description
88175view15:53, 29 July 2016JmeliusOntology Term : 'classic metabolic pathway' added !
85724view23:55, 6 June 2016Khansperslatest update
85610view22:57, 2 June 2016KhanspersQuick edit to datanode annotation or property
85549view23:48, 27 May 2016AlexanderPicoQuick edit to datanode annotation or property
85548view23:47, 27 May 2016AlexanderPicoQuick edit to datanode annotation or property
85541view22:43, 27 May 2016KhanspersModified description
85540view22:42, 27 May 2016KhanspersNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
?NMNAT3GeneProductENSG00000163864 (Ensembl)
ARTGeneProduct
CD38GeneProductENSG00000004468 (Ensembl)
CD73GeneProductENSG00000135318 (Ensembl)
ETCPathway
FADH2Metabolite
FADHMetaboliteHMDB01197 (HMDB)
Glyceraldehyde

3-phosphate

shuttle		Pathway
GlycolysisPathwayWP534 (WikiPathways)
L-Tryptophan (TRP)MetaboliteHMDB00929 (HMDB)
LactateMetaboliteHMDB00190 (HMDB)
Malate/aspartate shuttlePathway
NADHMetaboliteHMDB01487 (HMDB)
NADMetaboliteHMDB00902 (HMDB)
NADKGeneProductENSG00000008130 (Ensembl)
NADPHMetaboliteHMDB00221 (HMDB)
NADPMetaboliteHMDB00217 (HMDB)
NAMetaboliteHMDB01488 (HMDB)
NAMMetaboliteHMDB01406 (HMDB)
NAMNMetaboliteHMDB01132 (HMDB)
NAMPTGeneProductENSG00000105835 (Ensembl)
NMNMetabolite13553 (Chemspider)
NMNAT1GeneProductENSG00000173614 (Ensembl)
NMNAT2GeneProductENSG00000157064 (Ensembl)
NRMetaboliteHMDB00855 (HMDB)
NRKGeneProductENSG00000123572 (Ensembl)
Nicotinic acid (NA)MetaboliteHMDB01488 (HMDB)
PARP1GeneProductENSG00000143799 (Ensembl)
PRPPMetaboliteHMDB00280 (HMDB)
PyruvateMetaboliteHMDB00243 (HMDB)
SIRT1GeneProductENSG00000096717 (Ensembl)
SIRT2GeneProductENSG00000068903 (Ensembl)
SIRT3GeneProductENSG00000142082 (Ensembl)
SIRT4GeneProductENSG00000089163 (Ensembl)
SIRT5GeneProductENSG00000124523 (Ensembl)
SIRT6GeneProductENSG00000077463 (Ensembl)
SIRT7GeneProductENSG00000187531 (Ensembl)
TCA CyclePathwayWP73 (WikiPathways)
TRPMetaboliteHMDB00929 (HMDB)
dATPMetaboliteHMDB01532 (HMDB)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3644"
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