NAD+ biosynthetic pathways (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Verdin E; ''NAD� in aging, metabolism, and neurodegeneration.''; Science, 2015 PubMed Europe PMC Scholia
2. Bogan KL, Brenner C; ''Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition.''; Annu Rev Nutr, 2008 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	134904	view	03:03, 29 July 2024	Eweitz	Ontology Term : 'nicotinamide adenine dinucleotide biosynthesis, the salvage pathway' added !
	123910	view	12:41, 30 August 2022	Ddigles	Changed identifier for AMS (was identical to ACMS before). Added RHEA ID to ACMS to AMS conversion.
	118940	view	22:31, 4 June 2021	Eweitz	Ontology Term : 'nicotinamide adenine dinucleotide biosynthetic pathway' added !
	106653	view	21:16, 12 September 2019	Khanspers	Modified description
	106162	view	12:05, 16 August 2019	MaintBot	HMDB identifier normalization
	105654	view	05:14, 10 August 2019	Khanspers	Modified description
	90261	view	23:11, 27 October 2016	AlexanderPico	Changed areas to default background color
	88176	view	15:56, 29 July 2016	Jmelius	Ontology Term : 'classic metabolic pathway' added !
	85725	view	00:58, 7 June 2016	Khanspers	increased width of label
	85723	view	23:47, 6 June 2016	Khanspers	Modified description
	85721	view	23:13, 6 June 2016	Khanspers	Added rounded rectangle backgrounds
	85609	view	22:54, 2 June 2016	Khanspers	Added WPID for TCA cycle
	85547	view	23:45, 27 May 2016	AlexanderPico	Updated layout and oxidation on NAD+
	85546	view	23:32, 27 May 2016	AlexanderPico	Quick edit to datanode annotation or property
	85543	view	22:46, 27 May 2016	Khanspers	Modified description
	85542	view	22:45, 27 May 2016	Khanspers	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
3-HAA	Metabolite	HMDB01476 (HMDB)
ACMSD	GeneProduct	ENSG00000153086 (Ensembl)
ACMS	Metabolite	HMDB01330 (HMDB)
AMS	Metabolite	HMDB01330 (HMDB)
BST1	GeneProduct	ENSG00000109743 (Ensembl)
CD38	GeneProduct	ENSG00000004468 (Ensembl)
IDO1	GeneProduct	ENSG00000131203 (Ensembl)
L-Kynurenine	Metabolite	HMDB00684 (HMDB)
N-Formylkin	Metabolite	HMDB01200 (HMDB)
NADH	Metabolite	HMDB01487 (HMDB)
NAD	Metabolite	HMDB00902 (HMDB)
NADSYN1	GeneProduct	ENSG00000172890 (Ensembl)
NAMPT	GeneProduct	ENSG00000105835 (Ensembl)
NAPRT1	GeneProduct	ENSG00000147813 (Ensembl)
NMNAT1	GeneProduct	ENSG00000173614 (Ensembl)
Nicotinamide mononucleotide	Metabolite	13553 (Chemspider)
Nicotinamide riboside	Metabolite	HMDB00855 (HMDB)
Nicotinamide	Metabolite	HMDB01406 (HMDB)
Nicotinic acid adenine dinucleotide	Metabolite	HMDB01179 (HMDB)
Nicotinic acid mononucleotide	Metabolite	HMDB01132 (HMDB)
Nicotinic acid	Metabolite	HMDB01488 (HMDB)
PARP1	GeneProduct	ENSG00000143799 (Ensembl)
PARP2	GeneProduct	ENSG00000129484 (Ensembl)
PARP4	GeneProduct	ENSG00000102699 (Ensembl)
QPRT	GeneProduct	ENSG00000103485 (Ensembl)
Quinolinic acid	Metabolite	HMDB00232 (HMDB)
SIRT1	GeneProduct	ENSG00000096717 (Ensembl)
SIRT2	GeneProduct	ENSG00000068903 (Ensembl)
SIRT3	GeneProduct	ENSG00000142082 (Ensembl)
SIRT4	GeneProduct	ENSG00000089163 (Ensembl)
SIRT5	GeneProduct	ENSG00000124523 (Ensembl)
SIRT6	GeneProduct	ENSG00000077463 (Ensembl)
SIRT7	GeneProduct	ENSG00000187531 (Ensembl)
TCA cycle	Pathway
TDO2	GeneProduct	6999 (Entrez Gene)
TNKS2	GeneProduct	ENSG00000107854 (Ensembl)
TNKS	GeneProduct	ENSG00000173273 (Ensembl)
Tryptophan	Metabolite	HMDB00929 (HMDB)

Annotated Interactions

No annotated interactions