NAD+ biosynthetic pathways (Homo sapiens)

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1, 2DietDe novo biosynthesis pathwayNAD-consumingenzymesPreiss-Handler pathwayNADSYN1NAMPTAMSTCA cycleACMSDNicotinamideNicotinic acid mononucleotideTDO2ACMSNicotinamide mononucleotideL-KynurenineQuinolinic acidIDO1Nicotinic acid adenine dinucleotide3-HAACD38NADHN-FormylkinNAPRT1SIRT2Nicotinic acidNADNicotinamide ribosideQPRTPARP1TryptophanSIRT1NMNAT1BST1DietDietNMNAT1DietSalvage pathwayPARP4PARP2TNKSTNKS2SIRT3SIRT4SIRT5SIRT6SIRT7SIRT7


Description

No description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Bogan KL, Brenner C; ''Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition.''; Annu Rev Nutr, 2008 PubMed Europe PMC Scholia
  2. Verdin E; ''NAD� in aging, metabolism, and neurodegeneration.''; Science, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137654view12:05, 6 March 2025EweitzImprove padding
137653view12:04, 6 March 2025EweitzAlign interaction
137652view12:03, 6 March 2025EweitzEconomize layout
137651view12:01, 6 March 2025EweitzFix PathVisio / Kaavio graphical discrepancy
137650view11:59, 6 March 2025EweitzMake pathway clickable
137649view11:58, 6 March 2025EweitzEconomize layout
137648view11:48, 6 March 2025EweitzTailor node dimensions
137647view11:44, 6 March 2025EweitzIncrease font size
137633view21:57, 5 March 2025KhanspersModified description
134904view03:03, 29 July 2024EweitzOntology Term : 'nicotinamide adenine dinucleotide biosynthesis, the salvage pathway' added !
123910view12:41, 30 August 2022DdiglesChanged identifier for AMS (was identical to ACMS before). Added RHEA ID to ACMS to AMS conversion.
118940view22:31, 4 June 2021EweitzOntology Term : 'nicotinamide adenine dinucleotide biosynthetic pathway' added !
106653view21:16, 12 September 2019KhanspersModified description
106162view12:05, 16 August 2019MaintBotHMDB identifier normalization
105654view05:14, 10 August 2019KhanspersModified description
90261view23:11, 27 October 2016AlexanderPicoChanged areas to default background color
88176view15:56, 29 July 2016JmeliusOntology Term : 'classic metabolic pathway' added !
85725view00:58, 7 June 2016Khanspersincreased width of label
85723view23:47, 6 June 2016KhanspersModified description
85721view23:13, 6 June 2016KhanspersAdded rounded rectangle backgrounds
85609view22:54, 2 June 2016KhanspersAdded WPID for TCA cycle
85547view23:45, 27 May 2016AlexanderPicoUpdated layout and oxidation on NAD+
85546view23:32, 27 May 2016AlexanderPicoQuick edit to datanode annotation or property
85543view22:46, 27 May 2016KhanspersModified description
85542view22:45, 27 May 2016KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3-HAAMetaboliteHMDB01476 (HMDB)
ACMSDGeneProductENSG00000153086 (Ensembl)
ACMSMetaboliteHMDB01330 (HMDB)
AMSMetaboliteHMDB01330 (HMDB)
BST1GeneProductENSG00000109743 (Ensembl)
CD38GeneProductENSG00000004468 (Ensembl)
IDO1GeneProductENSG00000131203 (Ensembl)
L-KynurenineMetaboliteHMDB00684 (HMDB)
N-FormylkinMetaboliteHMDB01200 (HMDB)
NADHMetaboliteHMDB01487 (HMDB)
NADMetaboliteHMDB00902 (HMDB)
NADSYN1GeneProductENSG00000172890 (Ensembl)
NAMPTGeneProductENSG00000105835 (Ensembl)
NAPRT1GeneProductENSG00000147813 (Ensembl)
NMNAT1GeneProductENSG00000173614 (Ensembl)
Nicotinamide mononucleotideMetabolite13553 (Chemspider)
Nicotinamide ribosideMetaboliteHMDB00855 (HMDB)
NicotinamideMetaboliteHMDB01406 (HMDB)
Nicotinic acid adenine dinucleotideMetaboliteHMDB01179 (HMDB)
Nicotinic acid mononucleotideMetaboliteHMDB01132 (HMDB)
Nicotinic acidMetaboliteHMDB01488 (HMDB)
PARP1GeneProductENSG00000143799 (Ensembl)
PARP2GeneProductENSG00000129484 (Ensembl)
PARP4GeneProductENSG00000102699 (Ensembl)
QPRTGeneProductENSG00000103485 (Ensembl)
Quinolinic acidMetaboliteHMDB00232 (HMDB)
SIRT1GeneProductENSG00000096717 (Ensembl)
SIRT2GeneProductENSG00000068903 (Ensembl)
SIRT3GeneProductENSG00000142082 (Ensembl)
SIRT4GeneProductENSG00000089163 (Ensembl)
SIRT5GeneProductENSG00000124523 (Ensembl)
SIRT6GeneProductENSG00000077463 (Ensembl)
SIRT7GeneProductENSG00000187531 (Ensembl)
TCA cyclePathway
TDO2GeneProduct6999 (Entrez Gene)
TNKS2GeneProductENSG00000107854 (Ensembl)
TNKSGeneProductENSG00000173273 (Ensembl)
TryptophanMetaboliteHMDB00929 (HMDB)

Annotated Interactions

No annotated interactions

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