lncRNA-mediated mechanisms of therapeutic resistance (Homo sapiens)
From WikiPathways
Description
LncRNA-mediated mechanisms of therapeutic resistance. Mechanisms of tumor cell resistance to chemotherapy or hypoxia involving lncRNA include modulation of drug transporters and elimination, survival signaling pathways, cell cycle progression and DNA repair, sensitization to apoptosis, and modulation of intercellular communication mediated by extracellular vesicles.
This pathway is based on Fig 6 from Parasramka et al: http://www.ncbi.nlm.nih.gov/pubmed/27013343
Quality Tags
Ontology Terms
Saving...Bibliography
- Parasramka MA, Maji S, Matsuda A, Yan IK, Patel T; ''Long non-coding RNAs as novel targets for therapy in hepatocellular carcinoma.''; Pharmacol Ther, 2016 PubMed Europe PMC Scholia
History
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External references
DataNodes
| View all... |
| Name | Type | Database reference | Comment |
|---|---|---|---|
| AK126698 | Rna | ENSG00000203601 (Ensembl)  | |
| Apoptosis | Pathway | WP254 (WikiPathways) | |
| Bcl-xl | GeneProduct | ENSG00000171552 (Ensembl) | |
| Cell proliferation | Pathway | ||
| EV linc-RoR | Rna | ENSG00000258609 (Ensembl) | |
| EV linc-VLDLR | Rna | 401491 (Entrez Gene) | |
| G0/G1 cell cycle arrest | Pathway | ||
| HIF1A | GeneProduct | ENSG00000100644 (Ensembl) | |
| HOTAIR | Rna | ENSG00000228630 (Ensembl) | |
| MEG3 | Rna | ENSG00000214548 (Ensembl) | |
| MRUL | Rna | ||
| P-gp | GeneProduct | ENSG00000085563 (Ensembl) | |
| TP53 | GeneProduct | ENSG00000141510 (Ensembl) | |
| UCA1 | Rna | ENSG00000214049 (Ensembl) | |
| WNT6 | GeneProduct | ENSG00000115596 (Ensembl) | |
| linc-RoR | Rna | ENSG00000258609 (Ensembl) | |
| linc-VLDLR | Rna | 401491 (Entrez Gene) | |
| p21 | GeneProduct | ENSG00000124762 (Ensembl) |
Annotated Interactions
No annotated interactions
