Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling (Mus musculus)

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EIF2B2NFKB1AKT1TNFrecProtein synthesisPTENprotein synthesisPDK1SMAD2mTORC1amino acidsAMPKmTORC2Integrin B1SMAD3MTORIGFBP5TNFrecS6KTNFaGSK3BIRS1MURF1ActRIIBPLD1protein degradationTWEAKFoxO 4EPBMyostatinMAFbxIGF1recTNFaAMPKLC3PI3KILKPGC1IGF1JNK


Description

No description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Schiaffino S, Mammucari C; ''Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models.''; Skelet Muscle, 2011 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
90178view17:23, 21 October 2016KhanspersModified description
90125view05:13, 14 October 2016Khansperssimplified
89264view18:09, 27 August 2016KhanspersReverted to version '20:05, 14 August 2016' by Khanspers
89263view18:07, 27 August 2016Khansperschanged SMAD2/3 from complex to group
88788view20:05, 14 August 2016AAR&CoEdited Data Node
88778view19:48, 14 August 2016AAR&CoModify Datanode
88776view19:45, 14 August 2016AAR&CoModify Datanode
88773view19:41, 14 August 2016AAR&CoModify Datanodes
88707view17:02, 12 August 2016AAR&CoAdded Data Node
88706view17:01, 12 August 2016AAR&CoUpdated Data Nodes
88705view16:54, 12 August 2016AAR&CoPeriodical save, work in progress
88704view16:44, 12 August 2016AAR&CoPeriodical save, work in progress
88698view16:06, 12 August 2016AAR&CoPeriodical save, work in progress
88691view15:55, 12 August 2016AAR&CoPeriodical save, work in progress
88681view15:45, 12 August 2016AAR&CoPeriodical save, work in progress
88677view15:42, 12 August 2016AAR&CoPeriodical Save
88671view15:35, 12 August 2016AAR&CoPeriodical save, work in progress
88664view15:24, 12 August 2016AAR&CoAdded Pathway Nodes
88660view15:15, 12 August 2016AAR&CoModified description
88164view08:31, 29 July 2016Mkutmonunconnected line
87346view20:34, 21 July 2016AlexanderPicoChanged one gene over to mouse
87345view18:34, 21 July 2016AlexanderPicoReverted to version '16:35, 17 July 2016' by AlexanderPico
87192view08:34, 19 July 2016EgonwFixed the species.
87057view23:35, 17 July 2016AlexanderPicoOntology Term : 'insulin-like growth factor signaling pathway' added !
87056view23:34, 17 July 2016AlexanderPicoOntology Term : 'signaling pathway' added !
87055view23:34, 17 July 2016AlexanderPicoOntology Term : 'PW:0000004' removed !
87054view23:34, 17 July 2016AlexanderPicoOntology Term : 'growth factor signaling pathway' added !
87053view23:33, 17 July 2016AlexanderPicoOntology Term : 'cell of skeletal muscle' added !
87052view23:33, 17 July 2016AlexanderPicoOntology Term : 'regulatory pathway' added !
87051view23:31, 17 July 2016AlexanderPicoAdded lit ref
87050view23:30, 17 July 2016AlexanderPicoFixed interactions, pathway nodes, cell and layout
86130view13:06, 1 July 2016AAR&CoModified description
86129view13:06, 1 July 2016AAR&CoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
4EPBGeneProductENSG00000151247 (Ensembl) EIF4E
AKT1GeneProductENSG00000142208 (Ensembl)
AMPKGeneProductENSG00000111725 (Ensembl)
ActRIIBGeneProductENSG00000114739 (Ensembl)
EIF2B2GeneProductENSG00000119718 (Ensembl)
FoxO GeneProductfamily of transcription factors
GSK3BGeneProductENSG00000082701 (Ensembl)
IGF1GeneProductENSG00000017427 (Ensembl)
IGF1rec GeneProductENSG00000140443 (Ensembl)
IGFBP5GeneProductENSG00000115461 (Ensembl) most important of grup of IGF binding proteins that inhibit binding of IGF1 to its receptor
ILKGeneProductENSG00000166333 (Ensembl)
IRS1GeneProductENSG00000169047 (Ensembl) not sure, because also 2, 3, 4
Integrin B1GeneProductENSG00000150093 (Ensembl)
JNKProteinA0A087WVY6 (Uniprot-TrEMBL)
LC3GeneProductENSG00000101460 (Ensembl)
MAFbxGeneProductENSG00000156804 (Ensembl) FBXO32/atrogin-1
MTORGeneProductENSG00000198793 (Ensembl)
  • effect of AKT on MTOR is indirect
  • Part of two multiprotein complexes, TORC 1 and TORC 2
MURF1 GeneProductENSG00000158022 (Ensembl) TRIM63
MyostatinGeneProductENSG00000138379 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
PDK1GeneProductENSG00000152256 (Ensembl)
PGC1 GeneProductENSG00000109819 (Ensembl)
PI3KGeneProductENSG00000105851 (Ensembl) phosphatidlinositol 3-kinase
PLD1GeneProductENSG00000075651 (Ensembl)
PTENGeneProductENSG00000171862 (Ensembl)
Protein synthesis
S6KGeneProductENSG00000108443 (Ensembl)
SMAD2GeneProductENSG00000175387 (Ensembl)
SMAD3GeneProductENSG00000166949 (Ensembl)
TNFaGeneProductENSG00000228978 (EcoGene)
TNFaGeneProductENSG00000228978 (Ensembl)
TNFrecGeneProductENSG00000067182 (Ensembl)
TWEAKGeneProductENSG00000125657 (Ensembl)
amino acids
mTORC1
  • Complex of mTOR when bound to Raptor
  • rapamycin sensitive
mTORC2
  • complex of mTOR when bound to rictor
  • rapamycin insensitive
  • maximizes activation of AKT1
protein degradation
protein synthesis

Annotated Interactions

No annotated interactions

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