Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)

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6, 13, 32, 384, 549, 20, 25, 27, 36...2, 20, 25, 27, 30...16, 4535, 37, 55, 58, 7724, 29, 46, 651, 26, 377, 21, 68, 713, 48, 68, 725, 8, 17, 18, 23...12, 20, 25, 27, 30...16, 4122, 37, 7719, 26, 37, 64, 7026, 37, 75nucleoplasmcytosolSNRPG FUS NUP37 AAAS ZC3H11A3'-polyadenylated, capped pre-mRNA NUP37 TPR CF I - 68 kDa subunit NUP50 POLR2G HNRNPD POM121 DDX23 SRSF7 CPSF1 POLR2H HNRNPH2 SRRM1 Spliceosomal EComplexNUP54 POLDIP3 NHP2L1 RNPS1 GTF2F1 SRSF3 U5 snRNA NUP188 CPSF2 NXF1 PRPF6 DHX9 SRSF7 PCF11 CPSF2 U2AF1 CSTF3 CD2BP2 POLR2B U4atac snRNA SNRPF SNRNP25 2xMe-SNRPB POLR2E CstFPOLR2J NUP107 GPKOW CDC5L U2AF2 CPSF4 - 30 kDa subunit SRSF5 NUP188 SRSF5 2xMe-SNRPD3 POLR2L MAGOH PABPN1 NUP54 DHX16 ZCRB1 CSTF1 PLRG1 CCAR1 SRSF7 SF3B2 SNRPE YBX1 CPSF3 LSM2-8 complexPOLR2K POLR2D POLR2G SNRPD2 CTNNBL1 SF3B2 SRSF9 PRPF3 DHX9 U2 snRNA THOC1 POLR2B SF3B5 CPSF2 CWC15 SNRPG ZCRB1 mRNA with spliced exons RBM5 NUP98-3 U6 snRNA Mature Intronless transcript derived Histone mRNA U2AF1 DHX38 POLR2B POLR2D SRSF7 ELAVL1 POLR2F MAGOH SNRPF NUP88 CPSFCD2BP2 Mature Intronless transcript derived Histone mRNA HNRNPH1 PRPF8 capped, methylated pre-mRNA POLDIP3 NUP35 PTBP1 NCBP1 POLR2F NUP133 DDX39B SNRPG RBMX CPSF3 NUP93 SF3B14 SNRPE PABPN1 LSM5 ELAVL1THOC7 POLR2E NUP210 THOC5 YBX1 HNRNPU U2AF1 PABPN1 RNPS1 2xMe-SNRPB POLR2I CF I - 72 kDa subunit GTF2F1 BCAS2 NCBP1 LSM3 NUP155 U2AF2POLR2D SNRPD2 CCAR1 HNRNPC POLR2A DDX39B ZC3H11A PPIH NUPL2 Ceruloplasmin mRNA SART1 NCBP1 SRSF2 CPSF1 SNRNP200 POLR2L HNRNPU SF3B1 POLR2I POLR2E SF3A1 ATP U12 snRNA POLR2D POLR2J CDC5L HNRNPDHNRNPUL1 SNRPD2 EIF4E SRSF1 RBM5 EIF4E U1snRNP C protein PTBP1 ATAC C ComplexHNRNPA3 LSM2 SF3A3 HNRNPM U2 snRNA 2xMe-SNRPD3 PRPF8 LSM5 SNRNP25 RAE1 TXNL4A POLR2I POLR2D NUP50 Nup45 2xMe-SNRPD1 SNRPF U2AF2 NHP2L1 NUP98-5 HNRNPL capped, methylated pre-mRNA NCBP1 U4:U5:U6 tri-snRNPcomplexSARNP HNRNPR THOC3 SNRPD2 HNRNPU CPSF4 - 30 kDa subunit POLR2K ZC3H11A DDX5 SNRPE SRSF4 NUPL1-2 MAGOH METTL3 PTBP1 RBM8A 2xMe-SNRPB ALYREF NHP2L1 CPSF4 - 30 kDa subunit 2xMe-SNRPB 2xMe-SNRPD1 CTNNBL1 SF3A1 SRSF5 GTF2F1 ALYREF TPR 2xMe-SNRPD3 SF3B2 EIF4A3 RNPS1 U2AF2 NXT1 NCBP2SNRPA1 SF3A3 POLR2E PRPF8 SRSF11 EIF4A3 POLR2F CSTF2 POLR2K SRSF3 CPSF7 POLR2L SF3B5 U4 snRNA CHTOPintron-containingcomplexCDC40 NUP98-3 ZMAT5 SNRPB2 CPSF3 HNRNPH1 SF3B4 NHP2L1 DDX5 HNRNPA0 CstFNUP205 HNRNPUL1 NCBP1 SNRPG SRSF7 2xMe-SNRPD3 cappedpre-mRNA:CBC:RNAPol II(phosphorylated)complexEIF4A3 CWC15 NCBP2 U6 snRNA POLDIP3FUS mRNA:CBC:EJC:POLDIP3POLR2A PHF5A CCAR1 HNRNPH1 HNRNPA2B1 ELAVL2 NUP107 CDC5L POLR2F DDX23 RANBP2 GTF2F1 capped, methylated pre-mRNA 2xMe-SNRPB NUPL1-2 p-S5-POLR2A POLR2I MAGOH SRRT U2AF1 HNRNPA0 POLR2H POM121 POLR2B DNAJC8 FYTTD1 SRSF1 GTF2F1 RBMX 2xMe-SNRPB SF3B3 NCBP2 ALYREF POLR2D SF3B4 GTF2F1 DHX9 HNRNPR U1snRNP C protein SNRPG POLR2D U4 ATAC:U5:U6 ATACComplexNDC1 SF3B1 PCBP1 NCBP2 THOC5 NUP98-4 RBMX ALYREF PRPF3 Mature IntronlessTranscript DerivedHistonemRNA:TAP:Aly/RefcomplexHNRNPA3 POLR2H NUP98-4 NUP88 U5 snRNA HNRNPM SNRPE SRSF1 HNRNPD HNRNPA1 SRSF7 EIF4A3 CSTF1 U2 snRNA CPSF3 ZC3H11AEFTUD2 CPSF1 THOC6 SLBP CDC40 POLR2G NXF1CD2BP2 POLR2L HNRNPA1 SNRPB2 MatureintronlesstranscriptderivedHistonemRNA:SLBP:TAP:Aly/Ref complexNCBP1 CPSF1 NUDT21 CF I - 72 kDa subunit HNRNPC 2xMe-SNRPB NCBP2 HNRNPF U2AF2 SNRPD2 POLR2J SF3B14 SEH1L-2 SF3B3 U6 snRNA POLR2I SF3B3 SF3A3 RNPS1 NHP2L1 NXF1 2xMe-SNRPD1 2xMe-SNRPB TPR SNRNP48 SNRPD2 DHX16 SUGP1SF3B5 SNRPA1 Mature Intronless transcript derived Histone mRNA 3'-polyadenylated, capped pre-mRNA PRPF6 RBMX LSM2 POLR2C GTF2F2 GTF2F1 CSTF1 TRA2BHNRNPA2B1 ALYREF, FYTTD1,LUZP4U2AF2 POLR2D SRSF4 2xMe-SNRPD3 RNPC3 EIF4A3 Nup45 CWC15 SNRNP25 DHX38 Nuclear Pore Complex(NPC)THOC3 SUGP1 SNRNP40 POLR2J CF I - 68 kDa subunit RANBP2 NCBP2 SNRPD2 FYTTD1 POLR2J SRSF6 2xMe-SNRPD1 HNRNPU POLR2B SRSF2 CWC15 POLR2B NUP153 U2 snRNA POLR2L EFTUD2 PDCD7 POM121C CPSF4 - 30 kDa subunit PRPF4 CF IPOLR2L HNRNPA1 HNRNPD RNPC3 CPSF7 DDX5 lariat containing 5'-end cleaved mRNA POLR2C POLR2K LSM4 RAE1 POLR2H NUDT21 HNRNPR SF3B3 DDX23 SNRPA1 SRSF2 POLR2A SNRPF NUDT21 2xMe-SNRPD1 LSM6 SRSF5 PHF5A SNRPE RBM8A POLR2J PCF11 U2AF1 2xMe-SNRPD1 PLRG1 DHX16 SNRPF SRSF7 SF3B2 EFTUD2 p-S5-POLR2A POLR2J NUP107 POLR2A BCAS2 THOC3 NCBP2 YBX1 capped, methylated pre-mRNA CF I - 72 kDa subunit DHX9SRSF6 HNRNPF GTF2F1 2xMe-SNRPD1 THOC7 SNRNP40 NCBP1 YBX1 2xMe-SNRPB SRSF1 RBM8A POLR2K THOC2 NUPL1-2 SF3B4 CD2BP2 2xMe-SNRPB PTBP1 POLR2E RANBP2 HNRNPF2xMe-SNRPD3 EIF4A3 SRSF1 NCBP1 NXF1:NXT1NUP133 U2AF2 EFTUD2 MAGOH DDX5 POLR2E HNRNPH1 PTBP1 RNPS1 hSLU7 PCBP2 PRPF19 SNRPE POLR2L 2xMe-SNRPD3 POLR2G RBM5 POLR2B BCAS2 SF3B14 CPSF1 CLP1 NUP93 CPSF4 - 30 kDa subunit GTF2F2 POLR2J U2 snRNA EIF4E MAGOH SRSF9 U6 ATAC snRNA capped, methylated pre-mRNA ATAC B ComplexUPF3B CSTF3 SF3B2 POLR2G POLR2L NUP43 TXNL4A CSTF3 hTra2 NCBP1 SNRPG 2xMe-SNRPB SRRM1 hSLU7 DHX38 SNRNP200 SRRT PLRG1 GTF2F2 HNRNPA0 CDC40 2xMe-SNRPD1 SRSF9 SRSF2 NCBP1 SNRPD2 PABPN1 NXT1 2xMe-SNRPD1 PCF11 SNRNP200 LSM6 SNRNP35 SNRPB2 NXF1 SRRM1 CSTF1 SNRPG NUP43 CSTF3 RNPS1 POLR2I SNRPE U4atac snRNA POLR2J NUP188 PPIH WTAP YBX1 TRA2B ALYREF SNRNP48 CPSF7 TPR RNPS1Mature intronless transcript derived Histone mRNA SNRPF NUP62 POLR2K SRRM1 NUP98-3 PRPF3 EIF4A3 U5 snRNA PAPOLANUPL2 SRSF2 EIF4A3 NUPL2 POM121C NCBP1 HNRNPUL1 NUP50 SRRT PAPOLA SRSF2 HNRNPUL1 SF3B14 PRPF8 HSPA8 ALYREF POLR2C SF3B1 POLR2E 2xMe-SNRPD3 HSPA8 SF3B3 CF I - 68 kDa subunit HNRNPA3 POLR2H SF3B14 SRRM1 ELAVL2 U2AF1 CHTOP SNRPD2 POLR2A HNRNPA2B1 2xMe-SNRPD1 SNRNP40 U2 snRNPNUP35 POLR2H LSM4 CF I - 68 kDa subunit Spliceosomal ActiveC (B*) ComplexPOLR2G SNRPE SF3B2 Spliced mRNPU12 snRNA PAPOLAGTF2F2 HNRNPK HNRNPH1 NPC:NXF1:NXT1:EJC:CBC:mRNASRSF6FUS PRPF6 lariat containing 5'-end cleaved mRNA POLR2H 2xMe-SNRPB LSM2 U2AF2 FYTTD1 POLR2G SARNPNUP214 NXT1 SARNP PAPOLA BCAS2 POLR2A RBM8A DDX5 Nup45 U5 snRNA 2xMe-SNRPB SF3A1 NUP160 FIP1L1 NUP50 SRSF1 HSPA8 U5 snRNA SNRNP200 HNRNPC ALYREF PHF5A PRPF19 NCBP1 PTBP1 CASC3 CPSF3 NCBP2 LSM7 NCBP2 NCBP2 PCBP1 PCF11 CASC3 CF IISEH1L-2 DHX38 RNPS1 2xMe-SNRPD1 PCBP2 THOC7 ZC3H11A NUDT21 HNRNPKU2AF1 PDCD7 PCBP2 CLP1 NUP210 CCAR1 U2AF1 ELAVL2 SNRNP27 CPSF4 - 30 kDa subunit CHTOP POLR2D POLR2D CTNNBL1 CLP1 RBM8A U2AF1 SF3A1 CSTF2 THOC2 SF3A2 RBM5 NUP155 CPSF4 - 30 kDa subunit PCBP2 NUP54 MAGOH POLR2I NUP37 SRSF11 CF I - 68 kDa subunit SNRPG FYTTD1 PDCD7 NUP98-4 U6 ATAC snRNA SNRPB2 Mature Intronless transcript derived Histone mRNA THOC6 NCBP1 HNRNPA0 FIP1L1 SNRPF SF3A1 NCBP1 POLR2C ATAC A ComplexU12 snRNA SF3A1 SRRT SARNPATP CASC3SRSF6 HNRNPC SF3B2 METTL14 NUP62 CDC40 SNRPE SNRPA NUP85 LSM7 FUS SRRM1 POLR2F CF I - 68 kDa subunit GTF2F2 SRSF5 UPF3B SUGP1 DHX38 SF3A2 NHP2L1 USP39 POLR2C Mature intronlesstranscript derivedHistonepre-mRNA:CBCcomplex2xMe-SNRPB 2xMe-SNRPB NUP98-4 EIF4A3POLR2I POLR2C SF3A3 RANBP2 DDX23 NUP93 PLRG1 capped, methylated pre-mRNA POLR2J THOC3 SF3A1 CASC3 PCBP2 NUP155 HSPA8 NCBP2 LUZP4 SF3B3 SNRPE POLR2E GTF2F2 SRSF4 2xMe-SNRPD1 SARNP NCBP1 POLR2A POLR2F SRRT HNRNPA0 POLR2A PCF11 POLR2F NCBP2 SRSF11 SF3B4 POLR2F SNRNP27SF3B4 CLP1 THOC6 SRSF9 SRSF6 POLDIP3 FUS GTF2F2 NUP160 Mature intronlessderived mRNAcomplexSNRNP200 NUP160 LSM2 CDC40 SNRPA1 SRSF1 PRPF6 NCBP1 POLR2B NUP43 HNRNPU NUP88 PRPF6 SRSF6 AAAS CHTOP HNRNPH2 RNPC3 SNRNP70 NUP214 RAE1 RBM8A CPSF3 NCBP2 CPSF3 DDX39A,BU12 snRNA CDC40 NUP54 THOC1 CF I - 68 kDa subunit HSPA8 CPSF7 HNRNPL UPF3B HNRNPM FIP1L1 ALYREF SRSF5 THO complexHNRNPR CPSF3 2xMe-SNRPD3 NCBP2 CSTF2 NUP98-3 SNRPG RBM8A ALYREF LSM8 POLR2L POLR2D CPSF2 POLR2L HNRNPA3 HNRNPH2 SRSF7 2xMe-SNRPD3 PAPOLA SNRNP200 SRSF4 RBMXNUP98-5 PLRG1 NUP43 SF3B5 SRSF1 SF3B14 SNRPA ALYREF SRSF5 Mature intronless transcript derived mRNA NUP98-5 HNRNPL UPF3B hTra2 CF I - 68 kDa subunit pre-EJC:SpliceosomalC:pre-mRNP:CBCCPSF4 - 30 kDa subunit SRSF4 DHX16FIP1L1 CF I - 68 kDa subunit Mature IntronlessTranscript DerivedHistonemRNA:TAP:Aly/RefComplexEIF4EATPSRSF2 SRRM1 SRSF1 DHX16 mRNA with spliced exons SRSF11 SRSF2 CCAR1 NDC1 SRSF11 RANBP2 U4 ATAC snRNPSRSF5 RBM8A TXNL4A POLR2B SRSF7 SF3A2 U5 snRNA Nup45 LUZP4 UPF3B NHP2L1 polyadenylated,cappedmRNA:CBC:EJC:TREX:SRSF proteinsSNRPE HNRNPH2 NHP2L1 CPSF2 U5 snRNPMature intronlessderivedmRNA:TAP:Aly/RefcomplexU2AF2 post exon ligationcomplexPOLR2D CF I - 68 kDa subunit HNRNPK MAGOH Spliceosomal AComplexSRSF6 SEH1L-2 ELAVL2HNRNPA2B1POM121C DHX9 RBM5 PABPN1 Mature IntronlessTranscript DerivedmRNA:eIF4E ComplexPRPF6 SRSF3 HNRNPK SNRPF SF3B5 DDX23 POLR2H HNRNPA3 POLR2I TXNL4A SNRNP48 HNRNPA1 HNRNPF CPSF1 ZMAT5 HNRNPD SRSF6 FIP1L1 SRSF6 TXNL4A U4 snRNPALYREF GTF2F2 HNRNPU ATP HNRNPK POM121 CLP1 CPSF3 SRSF5 NXF1 SF3B1 PCBP1 PiSRSF9 capped, methylated pre-mRNA PRPF8 SRRM1 U5 snRNA POLR2H CSTF2 SART1 CSTF2 SRSF5POLR2K HNRNPL HNRNPA2B1 DHX38 SNRNP40 LSM8 NUP214 EFTUD2 SNRPD2 GTF2F2 SRSF11 THOC3 GPKOWDHX9 NCBP2 SRSF6 LSM3 SNRPG ZMAT5 PHF5A SRSF3 ALYREFALYREF, FYTTD1,LUZP4SNRPF EIF4A3 HSPA8 NCBP1 SRSF1 SRSF2 U1snRNP C protein SRSF1 CPSF4 - 30 kDa subunit NUP98-3 SF3A3 NUP85 HNRNPC TXNL4A POLR2K HNRNPA2B1 POLR2J SF3A2 PLRG1 RNPC3 POLR2A capped, methylated pre-mRNA NUP205 SEH1L-2 PRPF4 SNRPG SNRPF POLR2G SF3B4 ALYREF POM121C SNRPF NCBP2 SNRPG HNRNPH2 NUP85 SF3B5 PPIH EIF4ENXF1 SNRPD2 U2AF1NUP62 POLR2I SNRNP40 SRSF7 PRPF6 YBX1 SUGP1 PRPF19 HNRNPA3 CSTF3 POLR2F DHX9 RNPS1 LSM5 HNRNPA0 YBX1 NUP35 CPSF7 capped, methylated pre-mRNA PCF11 SRRM1 CDC40 ZCRB1 POLDIP3 NXF1HNRNPK GTF2F2 SNRNP35 SNRNP200 POLR2B CPSF7 SF3B4 SRSF4 POLR2K SF3B1 CPSF7 HNRNPA1 SRSF1 POLR2K mRNA with spliced exons PCF11 BCAS2 SNRNP35 DDX5SRRM1 SF3B2 U1 snRNA SNRNP27 SF3B1 HNRNPR CASC3 LSM2 2xMe-SNRPD1 YBX1 NDC1 CDC40 SNRNP48 CF I - 72 kDa subunit U6 snRNA CSTF2 NUP210 NUDT21 HNRNPA3 SRSF2 NUP98-5 RNPS1 ALYREF NUP155 POLR2G POLR2J SF3A1 ELAVL1 POLR2K UPF3B SF3B2 POLR2F SNRPB2 HNRNPF SNRPD2 POLR2G ELAVL1 POLR2E NUP188 SNRPG NUP35 CPSF3 POLR2C ELAVL2 POLR2I CPSF1 CSTF1 CPSF2 PAPOLA MatureintronlesstranscriptderivedHistonemRNA:SLBP:TAP:Aly/Ref complexPABPN1 SF3B14 DDX39A SNRPA1 PCBP1 POM121 SRRM1 U6 snRNA SRSF9 CPSF4 - 30 kDa subunit 2xMe-SNRPD3 CSTF2 SRSF6 POLR2K SRSF1 NUDT21 SRSF3 SUGP1 U11 snRNPSNRPD2 TXNL4A BCAS2 CASC3 SNRPD2 NCBP2 GTF2F1 CCAR1HNRNPU CWC15 SNRPD2 POLR2H SF3B4 BCAS2 NCBP2 hSLU7SRSF9 THOC2 POLR2G p-S5-POLR2A 2xMe-SNRPD1 CDC40 PHF5A ALYREF POLR2F POLR2F RBMX THOC1 SF3B5 POLR2L PRPF8 POLR2H LSM2 NUP205 CD2BP2 POLR2B LSM2 U11 snRNA SF3A3 PTBP12xMe-SNRPD3 CSTF1 ELAVL2 SF3B3 NCBP2 DDX23 ELAVL1 U2AF2 NUPL1-2 GPKOW GTF2F1 CDC5L FUS LSM6 SNRPF SRSF7 NCBP1 DHX38 SRSF3 PRPF6 NUP188 U2AF1 LSM2 U2AF1 excised intron LSM4 PAPOLA PCF11 CF IIDNAJC8 FIP1L1 SNRPD2 HNRNPA3TXNL4A THOC1 THOC7 PRPF31 SRRM1 YBX1 PCBP2RNApolymeraseII(phosphorylated):TFIIF complexDDX39A POLDIP3 NCBP2 SF3B3 SRSF6 GTF2F2 NCBP2 CWC15 NCBP2 SRSF11 POLR2H SF3B4 CPSF1 NCBP2 NUP160 POLDIP3 U5 snRNA SF3B2 SRRT2xMe-SNRPD3 SNRPG HNRNPA1 SRSF6 PRPF19 PAPOLA DDX23 CPSF2 CASC3 CD2BP2Magoh-Y14 complexU12 snRNA SRSF2THOC1 SLBP PRPF8 hTra2 PCBP1 2xMe-SNRPD3 DHX38 HNRNPK 3'-end cleaved mRNA with spliced exons SNRPD2 YBX1 FIP1L1 POLR2D PCF11 EFTUD2 PLRG1 POLR2I HNRNPA1CDC40 PAPOLA SNRPD2 SNRPD2 Mature SLBPindependent HistonemRNA:eIF4E complexATPEIF4A3 SF3B5 ALYREF U11 snRNA RBM5 EFTUD2 SNRNP25 DDX23 PDCD7 NUP62 RNPS1 SF3B4 CCAR1 LUZP4 PRPF19 CPSF4 - 30 kDa subunit NUP93 PRPF8 NHP2L1 SF3A2 HNRNPLHNRNPL capped, methylatedpre-mRNP:CBCcomplexSF3A2 SNRNP200 SNRPG PRPF19 PRPF19 2xMe-SNRPD3 THOC5 SNRPF POLR2J POLR2H CWC15 SF3B14 SARNP ZCRB1 2xMe-SNRPD1 SNRPE HNRNPR THOC2 DNAJC8 FIP1L1 EFTUD2 PCBP2 CPSF2 ELAVL2 TXNL4A HNRNPA2B1 2xMe-SNRPB SNRNP70 DDX39B NUP50 SNRNP200 DNAJC8 HNRNPL HNRNPA1 NCBP2 SNRPD2 NPC:NXF1:NXT1:EJC:CBC:mRNALSM2 PDCD7 SplicedmRNA:CBC:EJC:TREXPOLR2C Cleavage andPolyadenylationComplexNDC1 Mature intronlesstranscript derivedHistonemRNA:SLBP:eIF4EComplexhSLU7 POLR2E PABPN1 NXF1:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteinsCPSF1 HNRNPF DHX38 U6 ATAC snRNA HNRNPR TPR CCAR1 UPF3B POLR2G SNRPF ALYREF SRSF9 CWC15 DHX9 U2AF2 SNRPA1 NUP85 CPSF2 DHX9 POLR2J 2xMe-SNRPD1 SNRPF LUZP4 SNRPG NUP153 SRSF3 PRPF19 NCBP1 NCBP1 SF3B1 CPSF1 SRSF11 PRPF6 2xMe-SNRPD1 THOC2 SF3B5 NHP2L1 SNRNP40 LSM2 CLP1 Mature intronless derived mRNA CLP1 RNPS1 CPSF2 CDC40SRRT SRRM1 DHX38NUP43 ATAC C Complex withlariat containing5'-end cleaved mRNAHNRNPUL1SNRPE CPSF1 SRSF2 YBX1RNPS1 SF3B1 DDX23 PRPF8 2xMe-SNRPD3 FUScapped, methylated pre-mRNA ALYREF POLR2E RNPS1 POLR2D HNRNPA3 DNAJC8SRSF7 SRSF1 CLP1 ELAVL1 SNRPE POLR2G HNRNPD LSM3 EIF4A3 NUPL2 SRSF11 POLR2A NXF1 SRSF11 CDC5L GTF2F2 U1 snRNPPOLR2F POLR2F POLR2I RBM5 UPF3BCPSF7 U2AF1 THOC6 SNRPG U2 snRNA TXNL4A U5 snRNA SRSF2 NUP210 SF3B14 2xMe-SNRPB DNAJC8 CPSF3 NUP153 POLR2D SRSF5 FUS U4 snRNA HNRNPH2 ZMAT5 ALYREF Nuclear Pore Complex(NPC)NXF1 LSM2 DDX5 GTF2F2 CSTF3 SRSF3 DDX39A PCF11 HNRNPM CF I - 72 kDa subunit ALYREF DDX39B:ADPcapped, methylated pre-mRNA CD2BP2 HNRNPR POLR2E capped, methylatedpre-mRNA:CBCComplexSF3B1 PABPN1 POLR2G SF3B1 U4atac snRNA POLR2J CSTF3 SRSF11 CSTF1 FIP1L1 CSTF2 2xMe-SNRPB POLR2F SF3B14 SF3B14 HNRNPH1YBX1 SF3B5 POLR2B Mature intronless transcript derived Histone mRNA U11 snRNA NUP133 NUPL2 SNRPG SpliceosomalIntermediate C(Bact) ComplexCPSFFUS SF3B14 DDX23 DDX5 LSM2 SF3B3 NUP214 GTF2F1 SNRPF CTNNBL1 SF3B4 NXF1POM121C Ceruloplasmin mRNA SRSF5 NUDT21 NXF1 SRSF1 U11 snRNA Nup45 SRSF2 PRPF6 SUGP1 SRSF7 SNRNP40 PCBP1 CSTF2 SNRNP35 AAAS POLR2C DHX16 ADP PRPF6 PCBP2 SRSF6 SRRM1SNRPF hSLU7 RBM8A POLR2I SRRM1 SRSF2 RAE1 SRSF3SRSF9 THOC6 SNRPA1 THOC7 SNRNP40 NCBP1 SRSF6 SNRPE POLDIP3 HNRNPH1 HNRNPA0HNRNPD HNRNPD HNRNPA1 HNRNPH1 FIP1L1 NCBP2 SNRPE POLR2C U6 ATAC snRNPTHO complexU6 ATAC snRNA HNRNPM PHF5A POLR2C HNRNPM2xMe-SNRPD1 SUGP1 SRSF9 CDC5L CF ImRNA 3'-end cleavagefactorPOLR2I CASC3 HNRNPRSNRNP35 POLR2G Cap Binding Complex(CBC)POLR2E SUGP1 SRSF9 THOC6 HNRNPH2 SNRPB2 RBM5 LSM8 HNRNPF GTF2F2 SNRNP25 NXF1 HNRNPF POM121 HNRNPA0 SNRPE HNRNPA2B1 ALYREFSNRPF Mature intronless transcript derived Histone mRNA PAPOLA SF3B5 SNRNP48 SRSF4 p-S5-POLR2A CPSF7 RNPS1 SRSF6 FYTTD1 SF3B3 Nucleoplasmic matureintronless derivedmRNA:TAP:Aly/RefcomplexHNRNPA2B1 THOC1 PLRG1 NUP88 POLR2A SF3A2 GTF2F2 SF3B3 YBX1 2xMe-SNRPD1 3'-polyadenylated, capped pre-mRNA NUDT21 NXF1:NXT1PRPF4 CTNNBL1 U11 snRNA THOC5 NUP62 CCAR1 PRPF6 CHTOPNHP2L1 UPF3B SLBP NUP37 SNRPG SNRNP200 NUP98-5 EFTUD2 USP39 POLR2I PABPN12xMe-SNRPD3 POLR2B U1 snRNA CLP1 LUZP4 HNRNPK AAAS U6 ATAC snRNA THOC2 SRSF3 NUP155 CF I - 72 kDa subunit FIP1L1 PRPF31 2xMe-SNRPD3 SNRPF GPKOW NCBP2 SNRNP40 SF3B1 SNRPE NUP88 Mature intronless transcript derived Histone mRNA SNRNP70 HNRNPM HNRNPL POLR2B ELAVL1 SNRPG hTra2 SRSF7 ZMAT5 NUP133 RAE1 SRSF9 EFTUD2 hSLU7 SRSF1 NCBP2 SRSF4DDX39A SF3B1 ALYREF NUP54 SF3B1 HNRNPCPOLR2C CTNNBL1 PCBP1 NUP107 SRSF1 Nuclear Pore Complex(NPC)U2AF2 U2AF2 SNRPE HNRNPH2 CF I - 72 kDa subunit SRRT 3' end cleaved,ligated exoncontaining complexCPSFHSPA8 SF3B5 EFTUD2 POLR2H PCBP1HNRNPU HNRNPA0 SEH1L-2 Spliceosomal BComplexHNRNPUL1 POLR2K SRSF3 BCAS2 NUDT21 Spliceosomal activeC complex withlariat containing,5'-end cleavedpre-mRNP:CBCcomplexRBM8A PRPF8 CPSF3 ALYREF GTF2F1 MAGOH PTBP1 HNRNPK U1snRNP C protein CD2BP2 POLR2E POLR2K POLR2E HNRNPUL1 SNRPA POLR2J SNRPE CF I - 72 kDa subunit MAGOH CDC40 ZCRB1 GPKOW 2xMe-SNRPD1 SRSF6 SNRPA CSTF3 SNRPE HNRNPF CDC5L HNRNPD NUP85 GTF2F2 CPSF1 SF3A3 SNRPF 2xMe-SNRPD3 NUP107 RNPC3 ALYREFPOLR2B NHP2L1 SRSF11Mature intronless derived mRNA SRSF3 SRSF4 SNRPE NUP98-4 SNRNP40 GTF2F1 2xMe-SNRPD3 NUP37 HNRNPC SRSF12xMe-SNRPD3 SNRPG POLR2L POLR2C SNRPD2 HNRNPUL1 U4 snRNA GTF2F1 MatureIntronlesstranscriptderivedHistonemRNA:SLBP:CBP80:CBP20ALYREF POLR2H POLR2L NCBP1 SNRNP40 SRSF5 SF3B14 CSTF1 TRA2B RBMX SRSF4 SF3A3 PHF5A NUP153 POLR2K SNRPG HNRNPH2SF3B4 SART1PCBP2 AAAS NUP153 RNPS1 EFTUD2 HNRNPUPTBP1 SNRNP70 SRSF4 POLR2F SRSF7U2 snRNA HNRNPH1 HNRNPUL1 CSTF1 NXF1 DHX38 NXF1 CF I - 72 kDa subunit SRSF9SF3B5 U5 snRNA POLR2A SF3B3 SRSF6 ALYREF DNAJC8 SUGP1 PCBP1 NCBP1 ATPTHOC5 NUP205 CASC3 NXT1 2xMe-SNRPD3 POLR2C HNRNPL NCBP1SRSF2 NDC1 U2 snRNA SNRPA1 SF3B2 SNRPD2 SNRNP200 Mature intronless transcript derived mRNA 2xMe-SNRPB 2xMe-SNRPD1 UPF3B CPSF7 POLR2C mRNA(N6-adenosine)-methyltransferaseU6 snRNA HNRNPM POLR2H NCBP1 NUP93 SF3B2 2xMe-SNRPB NHP2L1 CSTF3 LSM7 THOC7 POLR2C HNRNPC PRPF8 2xMe-SNRPB capped pre-mRNA POLR2K SRSF2 DNAJC8 hSLU7U1 snRNA SRSF4 USP39SF3A2 THOC5 DHX38 CDC5L NUP133 CPSF2 POLR2G DDX23 DDX39A LUZP4 NXF1SF3B4 POLR2D SF3B2 SNRPF RBMX NCBP2 RBMX NCBP1 PHF5A POLR2L PRPF8 FIP1L1 PRPF31 HSPA8 HNRNPM NUDT21 NCBP1 TXNL4A SRSF3 CTNNBL1 POLR2B NUP214 SRSF7 U6 snRNA SNRNP40 NUPL1-2 YBX1 UPF3B CPSF4 - 30 kDa subunit POLR2L SLBP POLR2E CHTOP DDX39B PRP19-CDC5L complexEIF4A3 SNRPF SRSF2 NCBP1 RBM5SF3B3 SRSF7 CF I - 72 kDa subunit SRSF7 U5 snRNA TXNL4A GTF2F1 SNRPB2 SNRNP200 LSM2 ZC3H11A 2xMe-SNRPD1 U12 snRNPU5 snRNA NXT1 CPSF2 NUP35 SNRPB2 FYTTD1 CTNNBL1 HNRNPC NUP210 DDX23 capped, methylated pre-mRNA 2xMe-SNRPB THOC3 GPKOW DDX39B U1 snRNA NUP160 CLP1 NUP205 POLR2L SRRM1 GTF2F1 CD2BP2 PABPN16, 13, 322352, 61671444428, 511558, 771452, 6115114154, 54584028, 5134, 56, 6444941510, 11, 42, 434910, 11, 42, 4340151410, 11, 42, 4340


Description

Co-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per gene, which cannot serve as splicing substrates until both 5' and 3' ends of each intron are synthesized. Thus the time that it takes for pol II to synthesize each intron defines a minimal time and distance along the gene in which splicing factors can be recruited. The time that it takes for pol II to reach the end of the gene defines the maximal time in which splicing could occur co-transcriptionally. Thus, the kinetics of transcription can affect the kinetics of splicing.Any covalent change in a primary (nascent) mRNA transcript is mRNA Processing. For successful gene expression, the primary mRNA transcript needs to be converted to a mature mRNA prior to its translation into polypeptide. Eucaryotic mRNAs undergo a series of complex processing reactions; these begin on nascent transcripts as soon as a few ribonucleotides have been synthesized during transcription by RNA Polymerase II, through the export of the mature mRNA to the cytoplasm, and culminate with mRNA turnover in the cytoplasm. View original pathway at:Reactome.

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Bibliography

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  97. Gencheva M, Kato M, Newo AN, Lin RJ.; ''Contribution of DEAH-box protein DHX16 in human pre-mRNA splicing.''; PubMed Europe PMC Scholia
  98. Dufu K, Livingstone MJ, Seebacher J, Gygi SP, Wilson SA, Reed R.; ''ATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complex.''; PubMed Europe PMC Scholia
  99. Lin DH, Stuwe T, Schilbach S, Rundlet EJ, Perriches T, Mobbs G, Fan Y, Thierbach K, Huber FM, Collins LN, Davenport AM, Jeon YE, Hoelz A.; ''Architecture of the symmetric core of the nuclear pore.''; PubMed Europe PMC Scholia
  100. Hartmuth K, Urlaub H, Vornlocher HP, Will CL, Gentzel M, Wilm M, Lührmann R.; ''Protein composition of human prespliceosomes isolated by a tobramycin affinity-selection method.''; PubMed Europe PMC Scholia
  101. Grzybowska EA.; ''Human intronless genes: functional groups, associated diseases, evolution, and mRNA processing in absence of splicing.''; PubMed Europe PMC Scholia
  102. Yao C, Choi EA, Weng L, Xie X, Wan J, Xing Y, Moresco JJ, Tu PG, Yates JR, Shi Y.; ''Overlapping and distinct functions of CstF64 and CstF64τ in mammalian mRNA 3' processing.''; PubMed Europe PMC Scholia
  103. Reichert VL, Le Hir H, Jurica MS, Moore MJ.; ''5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly.''; PubMed Europe PMC Scholia
  104. Katahira J, Strässer K, Podtelejnikov A, Mann M, Jung JU, Hurt E.; ''The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human.''; PubMed Europe PMC Scholia
  105. Kaufmann I, Martin G, Friedlein A, Langen H, Keller W.; ''Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase.''; PubMed Europe PMC Scholia
  106. Wente SR, Rout MP.; ''The nuclear pore complex and nuclear transport.''; PubMed Europe PMC Scholia
  107. Viphakone N, Hautbergue GM, Walsh M, Chang CT, Holland A, Folco EG, Reed R, Wilson SA.; ''TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export.''; PubMed Europe PMC Scholia
  108. Will CL, Schneider C, Hossbach M, Urlaub H, Rauhut R, Elbashir S, Tuschl T, Lührmann R.; ''The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.''; PubMed Europe PMC Scholia
  109. Kosinski J, Mosalaganti S, von Appen A, Teimer R, DiGuilio AL, Wan W, Bui KH, Hagen WJ, Briggs JA, Glavy JS, Hurt E, Beck M.; ''Molecular architecture of the inner ring scaffold of the human nuclear pore complex.''; PubMed Europe PMC Scholia
  110. Behzadnia N, Golas MM, Hartmuth K, Sander B, Kastner B, Deckert J, Dube P, Will CL, Urlaub H, Stark H, Lührmann R.; ''Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes.''; PubMed Europe PMC Scholia
  111. Herold A, Suyama M, Rodrigues JP, Braun IC, Kutay U, Carmo-Fonseca M, Bork P, Izaurralde E.; ''TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture.''; PubMed Europe PMC Scholia
  112. Taniguchi I, Ohno M.; ''ATP-dependent recruitment of export factor Aly/REF onto intronless mRNAs by RNA helicase UAP56.''; PubMed Europe PMC Scholia
  113. Kota KP, Wagner SR, Huerta E, Underwood JM, Nickerson JA.; ''Binding of ATP to UAP56 is necessary for mRNA export.''; PubMed Europe PMC Scholia
  114. Padgett RA, Konarska MM, Grabowski PJ, Hardy SF, Sharp PA.; ''Lariat RNA's as intermediates and products in the splicing of messenger RNA precursors.''; PubMed Europe PMC Scholia
  115. Shen H, Zheng X, Luecke S, Green MR.; ''The U2AF35-related protein Urp contacts the 3' splice site to promote U12-type intron splicing and the second step of U2-type intron splicing.''; PubMed Europe PMC Scholia
  116. Wahle E, Rüegsegger U.; ''3'-End processing of pre-mRNA in eukaryotes.''; PubMed Europe PMC Scholia
  117. Grüter P, Tabernero C, von Kobbe C, Schmitt C, Saavedra C, Bachi A, Wilm M, Felber BK, Izaurralde E.; ''TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus.''; PubMed Europe PMC Scholia
  118. Bessonov S, Anokhina M, Will CL, Urlaub H, Lührmann R.; ''Isolation of an active step I spliceosome and composition of its RNP core.''; PubMed Europe PMC Scholia
  119. Singh J, Sikand K, Conrad H, Will CL, Komar AA, Shukla GC.; ''U6atac snRNA stem-loop interacts with U12 p65 RNA binding protein and is functionally interchangeable with the U12 apical stem-loop III.''; PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
115088view17:03, 25 January 2021ReactomeTeamReactome version 75
113530view12:00, 2 November 2020ReactomeTeamReactome version 74
112728view16:13, 9 October 2020ReactomeTeamReactome version 73
101644view11:51, 1 November 2018ReactomeTeamreactome version 66
101180view21:38, 31 October 2018ReactomeTeamreactome version 65
100706view20:10, 31 October 2018ReactomeTeamreactome version 64
100256view16:56, 31 October 2018ReactomeTeamreactome version 63
99809view15:20, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
93917view13:44, 16 August 2017ReactomeTeamreactome version 61
93494view11:25, 9 August 2017ReactomeTeamreactome version 61
88115view10:05, 26 July 2016RyanmillerOntology Term : 'regulatory pathway' added !
86590view09:21, 11 July 2016ReactomeTeamreactome version 56
83367view11:01, 18 November 2015ReactomeTeamVersion54
81532view13:04, 21 August 2015ReactomeTeamVersion53
77003view08:29, 17 July 2014ReactomeTeamFixed remaining interactions
76708view12:07, 16 July 2014ReactomeTeamFixed remaining interactions
76034view10:09, 11 June 2014ReactomeTeamRe-fixing comment source
75743view11:23, 10 June 2014ReactomeTeamReactome 48 Update
75093view14:04, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74829view10:05, 30 April 2014ReactomeTeamReactome46
74740view08:49, 30 April 2014ReactomeTeamReactome46
42105view21:57, 4 March 2011MaintBotAutomatic update
39915view05:56, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2xMe-SNRPB ProteinP14678 (Uniprot-TrEMBL)
2xMe-SNRPD1 ProteinP62314 (Uniprot-TrEMBL)
2xMe-SNRPD3 ProteinP62318 (Uniprot-TrEMBL)
3' end cleaved,

ligated exon

containing complex
ComplexR-HSA-72177 (Reactome)
3'-end cleaved mRNA with spliced exons R-NUL-71998 (Reactome)
3'-polyadenylated, capped pre-mRNA R-NUL-72184 (Reactome)
AAAS ProteinQ9NRG9 (Uniprot-TrEMBL)
ADP MetaboliteCHEBI:16761 (ChEBI)
ALYREF ProteinQ86V81 (Uniprot-TrEMBL)
ALYREF, FYTTD1, LUZP4ComplexR-HSA-8852182 (Reactome)
ALYREFProteinQ86V81 (Uniprot-TrEMBL)
ATAC A ComplexComplexR-HSA-77463 (Reactome)
ATAC B ComplexComplexR-HSA-77470 (Reactome)
ATAC C Complex with

lariat containing

5'-end cleaved mRNA
ComplexR-HSA-77475 (Reactome)
ATAC C ComplexComplexR-HSA-77473 (Reactome)
ATP MetaboliteCHEBI:15422 (ChEBI)
ATPMetaboliteCHEBI:15422 (ChEBI)
BCAS2 ProteinO75934 (Uniprot-TrEMBL)
CASC3 ProteinO15234 (Uniprot-TrEMBL)
CASC3ProteinO15234 (Uniprot-TrEMBL)
CCAR1 ProteinQ8IX12 (Uniprot-TrEMBL)
CCAR1ProteinQ8IX12 (Uniprot-TrEMBL)
CD2BP2 ProteinO95400 (Uniprot-TrEMBL)
CD2BP2ProteinO95400 (Uniprot-TrEMBL)
CDC40 ProteinO60508 (Uniprot-TrEMBL)
CDC40ProteinO60508 (Uniprot-TrEMBL)
CDC5L ProteinQ99459 (Uniprot-TrEMBL)
CF I - 68 kDa subunit R-HSA-72013 (Reactome)
CF I - 72 kDa subunit R-HSA-72014 (Reactome)
CF IIComplexR-HSA-72020 (Reactome)
CF IComplexR-HSA-72015 (Reactome)
CHTOP ProteinQ9Y3Y2 (Uniprot-TrEMBL)
CHTOPProteinQ9Y3Y2 (Uniprot-TrEMBL)
CLP1 ProteinQ92989 (Uniprot-TrEMBL)
CPSF1 ProteinQ10570 (Uniprot-TrEMBL)
CPSF2 ProteinQ9P2I0 (Uniprot-TrEMBL)
CPSF3 ProteinQ9UKF6 (Uniprot-TrEMBL)
CPSF4 - 30 kDa subunit R-NUL-71994 (Reactome)
CPSF7 ProteinQ8N684 (Uniprot-TrEMBL)
CPSFComplexR-HSA-71995 (Reactome)
CSTF1 ProteinQ05048 (Uniprot-TrEMBL)
CSTF2 ProteinP33240 (Uniprot-TrEMBL)
CSTF3 ProteinQ12996 (Uniprot-TrEMBL)
CTNNBL1 ProteinQ8WYA6 (Uniprot-TrEMBL)
CWC15 ProteinQ9P013 (Uniprot-TrEMBL)
Cap Binding Complex (CBC)ComplexR-HSA-77088 (Reactome)
Ceruloplasmin mRNA ProteinM13699 (EMBL)
Cleavage and

Polyadenylation

Complex
ComplexR-HSA-72021 (Reactome)
CstFComplexR-HSA-72006 (Reactome)
DDX23 ProteinQ9BUQ8 (Uniprot-TrEMBL)
DDX39A ProteinO00148 (Uniprot-TrEMBL)
DDX39A,BComplexR-HSA-8852231 (Reactome)
DDX39B ProteinQ13838 (Uniprot-TrEMBL)
DDX39B:ADPComplexR-HSA-8849115 (Reactome)
DDX5 ProteinP17844 (Uniprot-TrEMBL)
DDX5ProteinP17844 (Uniprot-TrEMBL)
DHX16 ProteinO60231 (Uniprot-TrEMBL)
DHX16ProteinO60231 (Uniprot-TrEMBL)
DHX38 ProteinQ92620 (Uniprot-TrEMBL)
DHX38ProteinQ92620 (Uniprot-TrEMBL)
DHX9 ProteinQ08211 (Uniprot-TrEMBL)
DHX9ProteinQ08211 (Uniprot-TrEMBL)
DNAJC8 ProteinO75937 (Uniprot-TrEMBL)
DNAJC8ProteinO75937 (Uniprot-TrEMBL)
EFTUD2 ProteinQ15029 (Uniprot-TrEMBL)
EIF4A3 ProteinP38919 (Uniprot-TrEMBL)
EIF4A3ProteinP38919 (Uniprot-TrEMBL)
EIF4E ProteinP06730 (Uniprot-TrEMBL)
EIF4EProteinP06730 (Uniprot-TrEMBL)
ELAVL1 ProteinQ15717 (Uniprot-TrEMBL)
ELAVL1ProteinQ15717 (Uniprot-TrEMBL)
ELAVL2 ProteinQ12926 (Uniprot-TrEMBL)
ELAVL2ProteinQ12926 (Uniprot-TrEMBL)
FIP1L1 ProteinQ6UN15 (Uniprot-TrEMBL)
FUS ProteinP35637 (Uniprot-TrEMBL)
FUSProteinP35637 (Uniprot-TrEMBL)
FYTTD1 ProteinQ96QD9 (Uniprot-TrEMBL)
GPKOW ProteinQ92917 (Uniprot-TrEMBL)
GPKOWProteinQ92917 (Uniprot-TrEMBL)
GTF2F1 ProteinP35269 (Uniprot-TrEMBL)
GTF2F2 ProteinP13984 (Uniprot-TrEMBL)
HNRNPA0 ProteinQ13151 (Uniprot-TrEMBL)
HNRNPA0ProteinQ13151 (Uniprot-TrEMBL)
HNRNPA1 ProteinP09651 (Uniprot-TrEMBL)
HNRNPA1ProteinP09651 (Uniprot-TrEMBL)
HNRNPA2B1 ProteinP22626 (Uniprot-TrEMBL)
HNRNPA2B1ProteinP22626 (Uniprot-TrEMBL)
HNRNPA3 ProteinP51991 (Uniprot-TrEMBL)
HNRNPA3ProteinP51991 (Uniprot-TrEMBL)
HNRNPC ProteinP07910 (Uniprot-TrEMBL)
HNRNPCProteinP07910 (Uniprot-TrEMBL)
HNRNPD ProteinQ14103 (Uniprot-TrEMBL)
HNRNPDProteinQ14103 (Uniprot-TrEMBL)
HNRNPF ProteinP52597 (Uniprot-TrEMBL)
HNRNPFProteinP52597 (Uniprot-TrEMBL)
HNRNPH1 ProteinP31943 (Uniprot-TrEMBL)
HNRNPH1ProteinP31943 (Uniprot-TrEMBL)
HNRNPH2 ProteinP55795 (Uniprot-TrEMBL)
HNRNPH2ProteinP55795 (Uniprot-TrEMBL)
HNRNPK ProteinP61978 (Uniprot-TrEMBL)
HNRNPKProteinP61978 (Uniprot-TrEMBL)
HNRNPL ProteinP14866 (Uniprot-TrEMBL)
HNRNPLProteinP14866 (Uniprot-TrEMBL)
HNRNPM ProteinP52272 (Uniprot-TrEMBL)
HNRNPMProteinP52272 (Uniprot-TrEMBL)
HNRNPR ProteinO43390 (Uniprot-TrEMBL)
HNRNPRProteinO43390 (Uniprot-TrEMBL)
HNRNPU ProteinQ00839 (Uniprot-TrEMBL)
HNRNPUL1 ProteinQ9BUJ2 (Uniprot-TrEMBL)
HNRNPUL1ProteinQ9BUJ2 (Uniprot-TrEMBL)
HNRNPUProteinQ00839 (Uniprot-TrEMBL)
HSPA8 ProteinP11142 (Uniprot-TrEMBL)
LSM2 ProteinQ9Y333 (Uniprot-TrEMBL)
LSM2-8 complexComplexR-HSA-6806791 (Reactome)
LSM3 ProteinP62310 (Uniprot-TrEMBL)
LSM4 ProteinQ9Y4Z0 (Uniprot-TrEMBL)
LSM5 ProteinQ9Y4Y9 (Uniprot-TrEMBL)
LSM6 ProteinP62312 (Uniprot-TrEMBL)
LSM7 ProteinQ9UK45 (Uniprot-TrEMBL)
LSM8 ProteinO95777 (Uniprot-TrEMBL)
LUZP4 ProteinQ9P127 (Uniprot-TrEMBL)
MAGOH ProteinP61326 (Uniprot-TrEMBL)
METTL14 ProteinQ9HCE5 (Uniprot-TrEMBL)
METTL3 ProteinQ86U44 (Uniprot-TrEMBL)
Magoh-Y14 complexComplexR-HSA-156657 (Reactome)
Mature

Intronless transcript derived Histone

mRNA:SLBP:CBP80:CBP20
ComplexR-HSA-111682 (Reactome)
Mature

intronless transcript derived Histone

mRNA:SLBP:TAP:Aly/Ref complex
ComplexR-HSA-159045 (Reactome)
Mature

intronless transcript derived Histone

mRNA:SLBP:TAP:Aly/Ref complex
ComplexR-HSA-159047 (Reactome)
Mature Intronless

Transcript Derived Histone mRNA:TAP:Aly/Ref

Complex
ComplexR-HSA-158480 (Reactome)
Mature Intronless

Transcript Derived Histone mRNA:TAP:Aly/Ref

complex
ComplexR-HSA-158479 (Reactome)
Mature Intronless

Transcript Derived

mRNA:eIF4E Complex
ComplexR-HSA-113818 (Reactome)
Mature Intronless transcript derived Histone mRNA R-NUL-111676 (Reactome)
Mature SLBP

independent Histone

mRNA:eIF4E complex
ComplexR-HSA-158501 (Reactome)
Mature intronless

derived mRNA:TAP:Aly/Ref

complex
ComplexR-HSA-158442 (Reactome)
Mature intronless

derived mRNA

complex
ComplexR-HSA-112167 (Reactome)
Mature intronless

transcript derived Histone mRNA:SLBP:eIF4E

Complex
ComplexR-HSA-141614 (Reactome)
Mature intronless

transcript derived Histone pre-mRNA:CBC

complex
ComplexR-HSA-156959 (Reactome)
Mature intronless derived mRNA R-NUL-158443 (Reactome) A mature mRNA that has been 3' cleaved, subsequently polyadenylated, and a m7G 5' cap. This product was derived from an intronless transcript.
Mature intronless transcript derived Histone mRNA R-NUL-113820 (Reactome)
Mature intronless transcript derived mRNA R-NUL-158444 (Reactome) A mature mRNA that has been 3' cleaved, subsequently polyadenylated, and a m7G 5' cap. This product was derived from an intronless transcript.
NCBP1 ProteinQ09161 (Uniprot-TrEMBL)
NCBP1ProteinQ09161 (Uniprot-TrEMBL)
NCBP2 ProteinP52298 (Uniprot-TrEMBL)
NCBP2ProteinP52298 (Uniprot-TrEMBL)
NDC1 ProteinQ9BTX1 (Uniprot-TrEMBL)
NHP2L1 ProteinP55769 (Uniprot-TrEMBL)
NPC:NXF1:NXT1:EJC:CBC:mRNAComplexR-HSA-113815 (Reactome)
NPC:NXF1:NXT1:EJC:CBC:mRNAComplexR-HSA-159259 (Reactome)
NUDT21 ProteinO43809 (Uniprot-TrEMBL)
NUP107 ProteinP57740 (Uniprot-TrEMBL)
NUP133 ProteinQ8WUM0 (Uniprot-TrEMBL)
NUP153 ProteinP49790 (Uniprot-TrEMBL)
NUP155 ProteinO75694 (Uniprot-TrEMBL)
NUP160 ProteinQ12769 (Uniprot-TrEMBL)
NUP188 ProteinQ5SRE5 (Uniprot-TrEMBL)
NUP205 ProteinQ92621 (Uniprot-TrEMBL)
NUP210 ProteinQ8TEM1 (Uniprot-TrEMBL)
NUP214 ProteinP35658 (Uniprot-TrEMBL)
NUP35 ProteinQ8NFH5 (Uniprot-TrEMBL)
NUP37 ProteinQ8NFH4 (Uniprot-TrEMBL)
NUP43 ProteinQ8NFH3 (Uniprot-TrEMBL)
NUP50 ProteinQ9UKX7 (Uniprot-TrEMBL)
NUP54 ProteinQ7Z3B4 (Uniprot-TrEMBL)
NUP62 ProteinP37198 (Uniprot-TrEMBL)
NUP85 ProteinQ9BW27 (Uniprot-TrEMBL)
NUP88 ProteinQ99567 (Uniprot-TrEMBL)
NUP93 ProteinQ8N1F7 (Uniprot-TrEMBL)
NUP98-3 ProteinP52948-3 (Uniprot-TrEMBL)
NUP98-4 ProteinP52948-4 (Uniprot-TrEMBL)
NUP98-5 ProteinP52948-5 (Uniprot-TrEMBL)
NUPL1-2 ProteinQ9BVL2-1 (Uniprot-TrEMBL)
NUPL2 ProteinO15504 (Uniprot-TrEMBL)
NXF1 ProteinQ9UBU9 (Uniprot-TrEMBL)
NXF1:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteinsComplexR-HSA-159100 (Reactome)
NXF1:NXT1ComplexR-HSA-8849118 (Reactome)
NXF1:NXT1ComplexR-HSA-8849140 (Reactome)
NXF1ProteinQ9UBU9 (Uniprot-TrEMBL)
NXT1 ProteinQ9UKK6 (Uniprot-TrEMBL)
Nuclear Pore Complex (NPC)ComplexR-HSA-157689 (Reactome)
Nucleoplasmic mature

intronless derived mRNA:TAP:Aly/Ref

complex
ComplexR-HSA-158446 (Reactome)
Nup45 ProteinQ9BVL2-2 (Uniprot-TrEMBL)
PABPN1 ProteinQ86U42 (Uniprot-TrEMBL)
PABPN1ProteinQ86U42 (Uniprot-TrEMBL)
PAPOLA ProteinP51003 (Uniprot-TrEMBL)
PAPOLAProteinP51003 (Uniprot-TrEMBL)
PCBP1 ProteinQ15365 (Uniprot-TrEMBL)
PCBP1ProteinQ15365 (Uniprot-TrEMBL)
PCBP2 ProteinQ15366 (Uniprot-TrEMBL)
PCBP2ProteinQ15366 (Uniprot-TrEMBL)
PCF11 ProteinO94913 (Uniprot-TrEMBL)
PDCD7 ProteinQ8N8D1 (Uniprot-TrEMBL)
PHF5A ProteinQ7RTV0 (Uniprot-TrEMBL)
PLRG1 ProteinO43660 (Uniprot-TrEMBL)
POLDIP3 ProteinQ9BY77 (Uniprot-TrEMBL)
POLDIP3ProteinQ9BY77 (Uniprot-TrEMBL)
POLR2A ProteinP24928 (Uniprot-TrEMBL)
POLR2B ProteinP30876 (Uniprot-TrEMBL)
POLR2C ProteinP19387 (Uniprot-TrEMBL)
POLR2D ProteinO15514 (Uniprot-TrEMBL)
POLR2E ProteinP19388 (Uniprot-TrEMBL)
POLR2F ProteinP61218 (Uniprot-TrEMBL)
POLR2G ProteinP62487 (Uniprot-TrEMBL)
POLR2H ProteinP52434 (Uniprot-TrEMBL)
POLR2I ProteinP36954 (Uniprot-TrEMBL)
POLR2J ProteinP52435 (Uniprot-TrEMBL)
POLR2K ProteinP53803 (Uniprot-TrEMBL)
POLR2L ProteinP62875 (Uniprot-TrEMBL)
POM121 ProteinQ96HA1 (Uniprot-TrEMBL)
POM121C ProteinA8CG34 (Uniprot-TrEMBL)
PPIH ProteinO43447 (Uniprot-TrEMBL)
PRP19-CDC5L complexComplexR-HSA-5420896 (Reactome)
PRPF19 ProteinQ9UMS4 (Uniprot-TrEMBL)
PRPF3 ProteinO43395 (Uniprot-TrEMBL)
PRPF31 ProteinQ8WWY3 (Uniprot-TrEMBL)
PRPF4 ProteinO43172 (Uniprot-TrEMBL)
PRPF6 ProteinO94906 (Uniprot-TrEMBL)
PRPF8 ProteinQ6P2Q9 (Uniprot-TrEMBL)
PTBP1 ProteinP26599 (Uniprot-TrEMBL)
PTBP1ProteinP26599 (Uniprot-TrEMBL)
PiMetaboliteCHEBI:18367 (ChEBI)
RAE1 ProteinP78406 (Uniprot-TrEMBL)
RANBP2 ProteinP49792 (Uniprot-TrEMBL)
RBM5 ProteinP52756 (Uniprot-TrEMBL)
RBM5ProteinP52756 (Uniprot-TrEMBL)
RBM8A ProteinQ9Y5S9 (Uniprot-TrEMBL)
RBMX ProteinP38159 (Uniprot-TrEMBL)
RBMXProteinP38159 (Uniprot-TrEMBL)
RNA

polymerase II

(phosphorylated):TFIIF complex
ComplexR-HSA-113404 (Reactome)
RNPC3 ProteinQ96LT9 (Uniprot-TrEMBL)
RNPS1 ProteinQ15287 (Uniprot-TrEMBL)
RNPS1ProteinQ15287 (Uniprot-TrEMBL)
SARNP ProteinP82979 (Uniprot-TrEMBL)
SARNPProteinP82979 (Uniprot-TrEMBL)
SART1 ProteinO43290 (Uniprot-TrEMBL)
SART1ProteinO43290 (Uniprot-TrEMBL)
SEH1L-2 ProteinQ96EE3-2 (Uniprot-TrEMBL)
SF3A1 ProteinQ15459 (Uniprot-TrEMBL)
SF3A2 ProteinQ15428 (Uniprot-TrEMBL)
SF3A3 ProteinQ12874 (Uniprot-TrEMBL)
SF3B1 ProteinO75533 (Uniprot-TrEMBL)
SF3B14 ProteinQ9Y3B4 (Uniprot-TrEMBL)
SF3B2 ProteinQ13435 (Uniprot-TrEMBL)
SF3B3 ProteinQ15393 (Uniprot-TrEMBL)
SF3B4 ProteinQ15427 (Uniprot-TrEMBL)
SF3B5 ProteinQ9BWJ5 (Uniprot-TrEMBL)
SLBP ProteinQ14493 (Uniprot-TrEMBL)
SNRNP200 ProteinO75643 (Uniprot-TrEMBL)
SNRNP25 ProteinQ9BV90 (Uniprot-TrEMBL)
SNRNP27 ProteinQ8WVK2 (Uniprot-TrEMBL)
SNRNP27ProteinQ8WVK2 (Uniprot-TrEMBL)
SNRNP35 ProteinQ16560 (Uniprot-TrEMBL)
SNRNP40 ProteinQ96DI7 (Uniprot-TrEMBL)
SNRNP48 ProteinQ6IEG0 (Uniprot-TrEMBL)
SNRNP70 ProteinP08621 (Uniprot-TrEMBL)
SNRPA ProteinP09012 (Uniprot-TrEMBL)
SNRPA1 ProteinP09661 (Uniprot-TrEMBL)
SNRPB2 ProteinP08579 (Uniprot-TrEMBL)
SNRPD2 ProteinP62316 (Uniprot-TrEMBL)
SNRPE ProteinP62304 (Uniprot-TrEMBL)
SNRPF ProteinP62306 (Uniprot-TrEMBL)
SNRPG ProteinP62308 (Uniprot-TrEMBL)
SRRM1 ProteinQ8IYB3 (Uniprot-TrEMBL)
SRRM1ProteinQ8IYB3 (Uniprot-TrEMBL)
SRRT ProteinQ9BXP5 (Uniprot-TrEMBL)
SRRTProteinQ9BXP5 (Uniprot-TrEMBL)
SRSF1 ProteinQ07955 (Uniprot-TrEMBL)
SRSF11 ProteinQ05519 (Uniprot-TrEMBL)
SRSF11ProteinQ05519 (Uniprot-TrEMBL)
SRSF1ProteinQ07955 (Uniprot-TrEMBL)
SRSF2 ProteinQ01130 (Uniprot-TrEMBL)
SRSF2ProteinQ01130 (Uniprot-TrEMBL)
SRSF3 ProteinP84103 (Uniprot-TrEMBL)
SRSF3ProteinP84103 (Uniprot-TrEMBL)
SRSF4 ProteinQ08170 (Uniprot-TrEMBL)
SRSF4ProteinQ08170 (Uniprot-TrEMBL)
SRSF5 ProteinQ13243 (Uniprot-TrEMBL)
SRSF5ProteinQ13243 (Uniprot-TrEMBL)
SRSF6 ProteinQ13247 (Uniprot-TrEMBL)
SRSF6ProteinQ13247 (Uniprot-TrEMBL)
SRSF7 ProteinQ16629 (Uniprot-TrEMBL)
SRSF7ProteinQ16629 (Uniprot-TrEMBL)
SRSF9 ProteinQ13242 (Uniprot-TrEMBL)
SRSF9ProteinQ13242 (Uniprot-TrEMBL)
SUGP1 ProteinQ8IWZ8 (Uniprot-TrEMBL)
SUGP1ProteinQ8IWZ8 (Uniprot-TrEMBL)
Spliced mRNA:CBC:EJC:TREXComplexR-HSA-8850671 (Reactome)
Spliced mRNPComplexR-HSA-72157 (Reactome)
Spliceosomal

Intermediate C

(Bact) Complex
ComplexR-HSA-72074 (Reactome)
Spliceosomal A ComplexComplexR-HSA-72068 (Reactome)
Spliceosomal Active C (B*) ComplexComplexR-HSA-72022 (Reactome)
Spliceosomal B ComplexComplexR-HSA-72069 (Reactome)
Spliceosomal E ComplexComplexR-HSA-72057 (Reactome)
Spliceosomal active

C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC

complex
ComplexR-HSA-77505 (Reactome)
THO complexComplexR-HSA-8849128 (Reactome)
THOC1 ProteinQ96FV9 (Uniprot-TrEMBL)
THOC2 ProteinQ8NI27 (Uniprot-TrEMBL)
THOC3 ProteinQ96J01 (Uniprot-TrEMBL)
THOC5 ProteinQ13769 (Uniprot-TrEMBL)
THOC6 ProteinQ86W42 (Uniprot-TrEMBL)
THOC7 ProteinQ6I9Y2 (Uniprot-TrEMBL)
TPR ProteinP12270 (Uniprot-TrEMBL)
TRA2B ProteinP62995 (Uniprot-TrEMBL)
TRA2BProteinP62995 (Uniprot-TrEMBL)
TXNL4A ProteinP83876 (Uniprot-TrEMBL)
U1 snRNA ProteinV00590 (EMBL)
U1 snRNPComplexR-HSA-71917 (Reactome) The U1 snRNP is a particle consisting of the U1 snRNA and Sm core plus unique snRNP polypeptides. The U1-specific polypeptides are 70K, A, and C. The Sm core polypeptides are B, B', D1, D2, D3, E, F, G. The Sm core is a heteroheptamer in the shape of a donut, containing either B or B', which are almost identical to each other.
U11 snRNA ProteinENST00000387069 (Ensembl)
U11 snRNPComplexR-HSA-77462 (Reactome)
U12 snRNA ProteinENST00000362512 (Ensembl)
U12 snRNPComplexR-HSA-77472 (Reactome)
U1snRNP C protein R-NUL-71916 (Reactome)
U2 snRNA ProteinX59360 (EMBL)
U2 snRNPComplexR-HSA-71980 (Reactome)
U2AF1 ProteinQ01081 (Uniprot-TrEMBL)
U2AF1ProteinQ01081 (Uniprot-TrEMBL)
U2AF2 ProteinP26368 (Uniprot-TrEMBL)
U2AF2ProteinP26368 (Uniprot-TrEMBL)
U4 ATAC snRNPComplexR-HSA-77465 (Reactome)
U4 ATAC:U5:U6 ATAC ComplexComplexR-HSA-77469 (Reactome)
U4 snRNA ProteinX59361 (EMBL)
U4 snRNPComplexR-HSA-71891 (Reactome)
U4:U5:U6 tri-snRNP complexComplexR-HSA-77506 (Reactome)
U4atac snRNA ProteinENST00000580972 (Ensembl)
U5 snRNA ProteinX04293 (EMBL)
U5 snRNPComplexR-HSA-71981 (Reactome)
U6 ATAC snRNA R-NUL-77466 (Reactome)
U6 ATAC snRNPComplexR-HSA-77467 (Reactome)
U6 snRNA ProteinX59362 (EMBL)
UPF3B ProteinQ9BZI7 (Uniprot-TrEMBL)
UPF3BProteinQ9BZI7 (Uniprot-TrEMBL)
USP39 ProteinQ53GS9 (Uniprot-TrEMBL)
USP39ProteinQ53GS9 (Uniprot-TrEMBL)
WTAP ProteinQ15007 (Uniprot-TrEMBL)
YBX1 ProteinP67809 (Uniprot-TrEMBL)
YBX1ProteinP67809 (Uniprot-TrEMBL)
ZC3H11A ProteinO75152 (Uniprot-TrEMBL)
ZC3H11AProteinO75152 (Uniprot-TrEMBL)
ZCRB1 ProteinQ8TBF4 (Uniprot-TrEMBL)
ZMAT5 ProteinQ9UDW3 (Uniprot-TrEMBL)
capped

pre-mRNA:CBC:RNA Pol II (phosphorylated)

complex
ComplexR-HSA-77089 (Reactome)
capped pre-mRNA R-NUL-72085 (Reactome)
capped, methylated

pre-mRNA:CBC

Complex
ComplexR-HSA-71954 (Reactome)
capped, methylated

pre-mRNP:CBC

complex
ComplexR-HSA-71955 (Reactome)
capped, methylated pre-mRNA R-NUL-77507 (Reactome)
excised intron R-NUL-72158 (Reactome)
hSLU7 ProteinO95391 (Uniprot-TrEMBL)
hSLU7ProteinO95391 (Uniprot-TrEMBL)
hTra2 R-HSA-72063 (Reactome)
intron-containing complexComplexR-HSA-72159 (Reactome)
lariat containing 5'-end cleaved mRNA R-NUL-156756 (Reactome)
mRNA (N6-adenosine)-methyltransferaseComplexR-HSA-72093 (Reactome)
mRNA 3'-end cleavage factorComplexR-HSA-72075 (Reactome)
mRNA with spliced exons R-NUL-72156 (Reactome)
mRNA:CBC:EJC:POLDIP3ComplexR-HSA-159329 (Reactome)
p-S5-POLR2A ProteinP24928 (Uniprot-TrEMBL)
polyadenylated,

capped

mRNA:CBC:EJC:TREX:SRSF proteins
ComplexR-HSA-156769 (Reactome)
post exon ligation complexComplexR-HSA-156556 (Reactome)
pre-EJC:Spliceosomal C:pre-mRNP:CBCComplexR-HSA-156656 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
3' end cleaved,

ligated exon

containing complex
ArrowR-HSA-72180 (Reactome)
3' end cleaved,

ligated exon

containing complex
R-HSA-72185 (Reactome)
ALYREF, FYTTD1, LUZP4ArrowR-HSA-75096 (Reactome)
ALYREF, FYTTD1, LUZP4R-HSA-8849157 (Reactome)
ALYREFArrowR-HSA-158447 (Reactome)
ALYREFArrowR-HSA-158484 (Reactome)
ALYREFArrowR-HSA-159050 (Reactome)
ALYREFR-HSA-111439 (Reactome)
ALYREFR-HSA-72107 (Reactome)
ALYREFR-HSA-77587 (Reactome)
ALYREFR-HSA-77594 (Reactome)
ATAC A ComplexArrowR-HSA-75080 (Reactome)
ATAC A ComplexR-HSA-75081 (Reactome)
ATAC B ComplexArrowR-HSA-75081 (Reactome)
ATAC B ComplexR-HSA-75079 (Reactome)
ATAC C Complex with

lariat containing

5'-end cleaved mRNA
ArrowR-HSA-75082 (Reactome)
ATAC C Complex with

lariat containing

5'-end cleaved mRNA
R-HSA-75083 (Reactome)
ATAC C ComplexArrowR-HSA-75079 (Reactome)
ATAC C ComplexR-HSA-75082 (Reactome)
ATPR-HSA-72185 (Reactome)
ATPR-HSA-8849157 (Reactome)
CASC3R-HSA-72160 (Reactome)
CCAR1R-HSA-72107 (Reactome)
CD2BP2R-HSA-72107 (Reactome)
CDC40ArrowR-HSA-75096 (Reactome)
CDC40R-HSA-72124 (Reactome)
CF IArrowR-HSA-72180 (Reactome)
CF IIArrowR-HSA-72180 (Reactome)
CF IIR-HSA-72231 (Reactome)
CF IR-HSA-72231 (Reactome)
CHTOPArrowR-HSA-75096 (Reactome)
CHTOPR-HSA-8849157 (Reactome)
CPSFArrowR-HSA-72185 (Reactome)
CPSFArrowR-HSA-77594 (Reactome)
CPSFR-HSA-72231 (Reactome)
Cap Binding Complex (CBC)ArrowR-HSA-111439 (Reactome)
Cap Binding Complex (CBC)ArrowR-HSA-77594 (Reactome)
Cleavage and

Polyadenylation

Complex
ArrowR-HSA-72231 (Reactome)
Cleavage and

Polyadenylation

Complex
R-HSA-72130 (Reactome)
CstFArrowR-HSA-72180 (Reactome)
CstFR-HSA-72231 (Reactome)
DDX39A,BR-HSA-8849157 (Reactome)
DDX39B:ADPArrowR-HSA-159101 (Reactome)
DDX5R-HSA-72107 (Reactome)
DHX16R-HSA-72130 (Reactome)
DHX38ArrowR-HSA-75096 (Reactome)
DHX38R-HSA-72124 (Reactome)
DHX9R-HSA-72107 (Reactome)
DNAJC8R-HSA-72124 (Reactome)
EIF4A3R-HSA-72130 (Reactome)
EIF4ER-HSA-158447 (Reactome)
EIF4ER-HSA-158484 (Reactome)
EIF4ER-HSA-159050 (Reactome)
ELAVL1R-HSA-72124 (Reactome)
ELAVL2R-HSA-72124 (Reactome)
FUSR-HSA-72107 (Reactome)
GPKOWR-HSA-72130 (Reactome)
HNRNPA0ArrowR-HSA-72160 (Reactome)
HNRNPA0R-HSA-72103 (Reactome)
HNRNPA1ArrowR-HSA-72160 (Reactome)
HNRNPA1R-HSA-72103 (Reactome)
HNRNPA2B1ArrowR-HSA-72160 (Reactome)
HNRNPA2B1R-HSA-72103 (Reactome)
HNRNPA3ArrowR-HSA-72160 (Reactome)
HNRNPA3R-HSA-72103 (Reactome)
HNRNPCArrowR-HSA-72160 (Reactome)
HNRNPCR-HSA-72103 (Reactome)
HNRNPDArrowR-HSA-72160 (Reactome)
HNRNPDR-HSA-72103 (Reactome)
HNRNPFArrowR-HSA-72160 (Reactome)
HNRNPFR-HSA-72103 (Reactome)
HNRNPH1ArrowR-HSA-72160 (Reactome)
HNRNPH1R-HSA-72103 (Reactome)
HNRNPH2ArrowR-HSA-72160 (Reactome)
HNRNPH2R-HSA-72103 (Reactome)
HNRNPKArrowR-HSA-72160 (Reactome)
HNRNPKR-HSA-72103 (Reactome)
HNRNPLArrowR-HSA-72160 (Reactome)
HNRNPLR-HSA-72103 (Reactome)
HNRNPMArrowR-HSA-72160 (Reactome)
HNRNPMR-HSA-72103 (Reactome)
HNRNPRArrowR-HSA-72160 (Reactome)
HNRNPRR-HSA-72103 (Reactome)
HNRNPUArrowR-HSA-72160 (Reactome)
HNRNPUL1R-HSA-72107 (Reactome)
HNRNPUR-HSA-72103 (Reactome)
LSM2-8 complexArrowR-HSA-72130 (Reactome)
Magoh-Y14 complexR-HSA-156661 (Reactome)
Mature

Intronless transcript derived Histone

mRNA:SLBP:CBP80:CBP20
R-HSA-77587 (Reactome)
Mature

intronless transcript derived Histone

mRNA:SLBP:TAP:Aly/Ref complex
ArrowR-HSA-159046 (Reactome)
Mature

intronless transcript derived Histone

mRNA:SLBP:TAP:Aly/Ref complex
ArrowR-HSA-77587 (Reactome)
Mature

intronless transcript derived Histone

mRNA:SLBP:TAP:Aly/Ref complex
R-HSA-159046 (Reactome)
Mature

intronless transcript derived Histone

mRNA:SLBP:TAP:Aly/Ref complex
R-HSA-159050 (Reactome)
Mature Intronless

Transcript Derived Histone mRNA:TAP:Aly/Ref

Complex
ArrowR-HSA-158481 (Reactome)
Mature Intronless

Transcript Derived Histone mRNA:TAP:Aly/Ref

Complex
R-HSA-158484 (Reactome)
Mature Intronless

Transcript Derived Histone mRNA:TAP:Aly/Ref

complex
ArrowR-HSA-111439 (Reactome)
Mature Intronless

Transcript Derived Histone mRNA:TAP:Aly/Ref

complex
R-HSA-158481 (Reactome)
Mature Intronless

Transcript Derived

mRNA:eIF4E Complex
ArrowR-HSA-158447 (Reactome)
Mature SLBP

independent Histone

mRNA:eIF4E complex
ArrowR-HSA-158484 (Reactome)
Mature intronless

derived mRNA:TAP:Aly/Ref

complex
ArrowR-HSA-158441 (Reactome)
Mature intronless

derived mRNA:TAP:Aly/Ref

complex
R-HSA-158447 (Reactome)
Mature intronless

derived mRNA

complex
R-HSA-77594 (Reactome)
Mature intronless

transcript derived Histone mRNA:SLBP:eIF4E

Complex
ArrowR-HSA-159050 (Reactome)
Mature intronless

transcript derived Histone pre-mRNA:CBC

complex
R-HSA-111439 (Reactome)
NCBP1ArrowR-HSA-77587 (Reactome)
NCBP2ArrowR-HSA-77587 (Reactome)
NPC:NXF1:NXT1:EJC:CBC:mRNAArrowR-HSA-75096 (Reactome)
NPC:NXF1:NXT1:EJC:CBC:mRNAArrowR-HSA-75097 (Reactome)
NPC:NXF1:NXT1:EJC:CBC:mRNAR-HSA-75097 (Reactome)
NPC:NXF1:NXT1:EJC:CBC:mRNAR-HSA-75098 (Reactome)
NXF1:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteinsArrowR-HSA-159101 (Reactome)
NXF1:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteinsR-HSA-75096 (Reactome)
NXF1:NXT1ArrowR-HSA-75098 (Reactome)
NXF1:NXT1R-HSA-159101 (Reactome)
NXF1ArrowR-HSA-158447 (Reactome)
NXF1ArrowR-HSA-158484 (Reactome)
NXF1ArrowR-HSA-159050 (Reactome)
NXF1R-HSA-111439 (Reactome)
NXF1R-HSA-77587 (Reactome)
NXF1R-HSA-77594 (Reactome)
Nuclear Pore Complex (NPC)ArrowR-HSA-111439 (Reactome)
Nuclear Pore Complex (NPC)ArrowR-HSA-158441 (Reactome)
Nuclear Pore Complex (NPC)ArrowR-HSA-158447 (Reactome)
Nuclear Pore Complex (NPC)ArrowR-HSA-158481 (Reactome)
Nuclear Pore Complex (NPC)ArrowR-HSA-158484 (Reactome)
Nuclear Pore Complex (NPC)ArrowR-HSA-159046 (Reactome)
Nuclear Pore Complex (NPC)ArrowR-HSA-159050 (Reactome)
Nuclear Pore Complex (NPC)ArrowR-HSA-75096 (Reactome)
Nuclear Pore Complex (NPC)ArrowR-HSA-75097 (Reactome)
Nuclear Pore Complex (NPC)ArrowR-HSA-75098 (Reactome)
Nuclear Pore Complex (NPC)ArrowR-HSA-77587 (Reactome)
Nuclear Pore Complex (NPC)ArrowR-HSA-77594 (Reactome)
Nuclear Pore Complex (NPC)R-HSA-75096 (Reactome)
Nuclear Pore Complex (NPC)mim-catalysisR-HSA-75097 (Reactome)
Nucleoplasmic mature

intronless derived mRNA:TAP:Aly/Ref

complex
ArrowR-HSA-77594 (Reactome)
Nucleoplasmic mature

intronless derived mRNA:TAP:Aly/Ref

complex
R-HSA-158441 (Reactome)
PABPN1ArrowR-HSA-72185 (Reactome)
PABPN1R-HSA-72231 (Reactome)
PAPOLAArrowR-HSA-72185 (Reactome)
PAPOLAR-HSA-72231 (Reactome)
PAPOLAmim-catalysisR-HSA-72185 (Reactome)
PCBP1ArrowR-HSA-72160 (Reactome)
PCBP1R-HSA-72103 (Reactome)
PCBP2ArrowR-HSA-72160 (Reactome)
PCBP2R-HSA-72103 (Reactome)
POLDIP3R-HSA-8849157 (Reactome)
PRP19-CDC5L complexR-HSA-72124 (Reactome)
PTBP1ArrowR-HSA-72160 (Reactome)
PTBP1R-HSA-72103 (Reactome)
PiArrowR-HSA-159101 (Reactome)
R-HSA-111439 (Reactome) Histone mRNAs are exported by a mechanism that requires TAP, the key factor requires for transport of polyadenylated mRNAs. How TAP is recruited to the histone mRNAs is not known, but it is clear that transport can occur in the absence of either the stemloop or of SLBP. The mature transcript docks at the NPC, in the course of transport CBC will be lost from the mRNA cap, and remain in the nucleous.
R-HSA-156661 (Reactome) At the beginning of this reaction, 1 molecule of 'Magoh-Y14 complex', and 1 molecule of 'Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex' are present. At the end of this reaction, 1 molecule of 'Exon Junction Complex' is present.

This reaction takes place in the 'nucleoplasm'.

R-HSA-158441 (Reactome) The nucleoplasmic 3' polyadenylated, capped intronless mRNA and TAP are transported through the NPC to the cyotplasmic side of the pore.
R-HSA-158447 (Reactome) The cytoplasmic 3' polyadenylated, capped intronless mRNA and TAP are released from the NPC into the cytosol. Cytosolic TAP will be recycled to the nucleous, while the 3' polyadenylated, capped intronless mRNA is bound by eIF4E and destined for translation.
R-HSA-158481 (Reactome) The mature SLBP independent intronless histone mRNA is transported through the nucler pore to the cytoplasmic side.
R-HSA-158484 (Reactome) At some point eIF4E binds the mature mRNA. While TAP and Aly/Ref are released and will be reycled back to the nucleoplasm.
R-HSA-159046 (Reactome) Once the transport complex is fully assembled the mature mRNA can be translocated from the nucleoplasm to the cytoplasm. The assembled complex starts at the nucleoplasmic basket, travels through the pore, and ends it journey at the cytoplasmic face of the nuclear pore complex.
R-HSA-159050 (Reactome) At some point eIF4E binds the mature mRNA. While TAP and Aly/Ref are released and will be reycled back to the nucleoplasm.
R-HSA-159101 (Reactome) The mRNA is transferred from ALYREF of the TREX complex to NXF1 (TAP) of the NXF1:NXT1 export complex (Hautbergue et al. 2008). Interaction between the TREX complex and NXF1 exposes the arginine-rich RNA-binding domain of NXF1 (Viphakone et al. 2012). Methylation of arginine residues on ALYREF also appears to be necessary for dissociation of mRNA from ALYREF during the transfer (Hung et al. 2010). The interaction between ALYREF and NXF1 occurs in the vicinity of nuclear speckles (Teng and Wilson 2013). DDX39B (UAP56) binds (Kota et al. 2008) and hydrolyzes ATP (Taniguchi and Ohno 2008). UAP56 is believed to hydrolyze ATP and UAP56:ADP is believed to dissociate at some point during the transfer of the mRNA to NXF1 (Taniguchi and Ohno 2008, Chang et al. 2013).
R-HSA-72095 (Reactome) In addition to the methylation of the 5'-cap, there is methylation of internal nucleotides in the mRNA. This methylation can occur in translated and untranslated regions. One to three methyl groups have been seen per mRNA molecule, but methylation is non-stoichiometric. The most frequent methylation observed is at the N6 position of adenosine. The function of mRNA internal methylation, if any, is unknown.
R-HSA-72103 (Reactome) After the nascent pre-mRNA undergoes the initial capping and methylation reactions, it gets associated with numerous factors, including the various heterogeneous nuclear ribonucleoproteins (hnRNPS), the nuclear Cap-Binding Complex, and many splicing factors that make the pre-mRNA a substrate for splicing, 3'-end processing, and in some cases editing.
R-HSA-72107 (Reactome) Pre-mRNA transcripts become rapidly associated with many RNA-binding proteins, including hnRNP proteins, cap-binding proteins, SR proteins, etc; in the test tube this binding does not require splice sites or ATP. The E complex, or early complex, is the first detectable functional intermediate in spliceosome assembly in vitro. It is an ATP-independent complex. When a functional 5' splice site is present, it is bound by the U1 snRNP. The splicing factor U2AF (65 and 35 kDa subunits) binds to the polypyrimidine tract (Y)n and the AG dinucleotide at the 3' splice site, respectively. SF1/mBBP binds to the branch site. Binding of many of these factors is cooperative; e.g., SR proteins and U2AF apparently interact with each other, facilitating their binding to the pre-mRNA. In the presence of ATP, the E complex is converted to the first ATP-dependent spliceosomal complex, namely the A complex.
R-HSA-72124 (Reactome) The A complex is the first ATP-dependent complex in spliceosome assembly. U2AF recruits the U2 snRNP to bind to the branch site in the E complex in an ATP-dependent fashion, to form the A complex. The U2 snRNA base-pairs with the branch site, causing the branch-site adenosine to bulge out, which later positions it for nucleophilic attack at the 5' splice site. The A complex serves as a substrate for formation of the B complex.
R-HSA-72127 (Reactome) The formation of the B complex is ATP-dependent, and both the 5' and 3' splice sites are essential for B complex assembly. The U4 and U6 snRNPS are extensively base-paired, and this U4:U6 complex associates with the U5 snRNP to form a tri-snRNP particle. This tri-snRNP particle then binds to the spliceosomal A complex, to form the spliceosomal B complex.
R-HSA-72130 (Reactome) The intermediate spliceosomal C complex (also called the Bact or B(act) complex) is a very short-lived intermediate; the splicing intermediates are rapidly converted to splicing products. Also, the spliced products are released very rapidly, and no complex containing both the splicing products has been isolated. Conversion of the spliceosomal B complex to the spliceosomal C complex requires ATP. The extensive base-pairing between the U4 and U6 snRNAs is disrupted during the formation of the C complex, which is thought to require helicase-type activity associated with the DEAD box factors. The U4 snRNP and U1 snRNP dissociate from the complex and the LSM2-6 complex of the U6 snRNP is lost, apparently allowing the U6 snRNA to then base-pair with the U2 snRNA and the 5' end of the splice site on the mRNA (Bessonov et al. 2010).
R-HSA-72139 (Reactome) The active C complex is formed due to a conformational change in the intermediate C complex. After formation of the active C complex, the splicing reactions occur very rapidly.
R-HSA-72143 (Reactome) In the first catalytic step of mRNA splicing, the 2' OH group of the bulged A at the branch site performs a nucleophilic attack on the 5' splice site phosphodiester bond, resulting in cleavage of the bond between the 5' exon and the 5' end of the intron, and formation of a new bond between the 5' end of the intron and the branch site A. This results in a lariat-shaped intermediate, with the intron still attached to the 3' exon. The branch site A has a 2'-5' phosphodiester bond with the G at the beginning of the intron, in addition to the usual 5'-3' and 3'-5'phosphodiester bonds.
R-HSA-72160 (Reactome) The second step of the splicing reaction results in cleavage of the transcript at the 3'splice site, and results in ligation of the two exons and excision of the intron.
R-HSA-72180 (Reactome) Endonucleolytic cleavage separates the pre-mRNA into an upstream fragment destined to become the mature mRNA, and a downstream fragment that is rapidly degraded. Cleavage depends on two signals in the RNA, a highly conserved hexanucleotide, AAUAAA, 10 to 30 nucleotides upstream of the cleavage site, and a poorly conserved GU- or U-rich downstream element. Additional sequences, often upstream of AAUAAA, can enhance the efficiency of the reaction. Cleavage occurs most often after a CA dinucleotide. A single gene can have more than one 3' processing site.

Cleavage is preceded by the assembly of a large processing complex, the composition of which is poorly defined. ATP, but not its hydrolysis, is required for assembly. Cleavage at the 3'-end of mRNAs depends on a number of protein factors. CPSF, a heterotetramer, binds specifically to the AAUAAA sequence. The heterotrimer CstF binds the downstream element. CF I, which appears to be composed of two subunits, one of several related larger polypeptides and a common smaller one, also binds RNA, but with unknown specificity. RNA recognition by these proteins is cooperative. Cleavage also requires CF II, composed of at least two subunits, and poly(A) polymerase, the enzyme synthesizing the poly(A) tail in the second step of the reaction. The polypeptide catalyzing the hydrolysis of the phosphodiester bond remains to be identified.

Cleavage produces a 3'-OH on the upstream fragment and a 5'-phosphate on the downstream fragment. At some unknown point after cleavage, the downstream RNA fragment, CstF, CF I and CF II are thought to be released, whereas CPSF and poly(A) polymerase remain to carry out polyadenylation.

R-HSA-72185 (Reactome) The upstream fragment generated by 3' cleavage of the pre-mRNA receives a poly(A) tail of approximately 250 AMP residues in a reaction depending on the AAUAAA sequence 10 to 30 nucleotides upstream of the 3' end. Polyadenylation is carried out by three proteins: Poly(A) polymerase carries the catalytic activity. The enzyme has no specificity for any particular RNA sequence, and it also has a very low affinity for the RNA.

Under physiological conditions, the activity of poly(A) polymerase thus depends on two auxiliary factors, both of which bind to specific RNA sequences and recruit the enzyme by a direct contact. One of these proteins is the heterotetrameric CPSF, which binds the AAUAAA sequence and is also essential for 3' cleavage. The second is the nuclear poly(A) binding protein (PABPN1), which binds the growing poly(A) tails once this has reached a length of about ten nucleotides. Stimulation of poly(A) polymerase by both proteins is synergistic and results in processive elongation of the RNA, i.e. the polymerase adds AMP residues without dissociating from the RNA. The processive reaction is terminated when the tail has reached a length of about 250 nucleotides.

R-HSA-72231 (Reactome)
R-HSA-75079 (Reactome) At the beginning of this reaction, 1 molecule of 'ATAC B Complex' is present. At the end of this reaction, 1 molecule of 'U4 ATAC snRNP', and 1 molecule of 'ATAC C Complex' are present.

This reaction takes place in the 'nucleus'.

R-HSA-75080 (Reactome) U12-type AT-AC introns are distinguished from the major U2-type introns by the consensus sequences of their highly conserved splicing signals. U12 introns have the 5' ss consensus sequence (G/A)TATCCTTT, the branchpoint sequence TTTCCTTAACT and the 3' ss (C/T)AG. Initial recognition of AT-AC introns involves interaction of U12 snRNP with the branch-point sequence and U11 with the 5' ss. Unlike the major splicing pathway, U11 and U12 are in a complex and interact with the pre-mRNA simultaneously, binding in an ATP-dependent manner as a di-snRNP complex and likely bridging the 5' ss and 3' ss region.

Twenty proteins have been identified in the U11/U12 di-snRNP complex including the snRNP Sm proteins B’, B, D3, D2, D1, E, F, and G which are identical to the major splicing pathway Sm proteins. A U2 snRNP core protein complex, SF3b is also found in the U11/U12 di-snRNP, including p14, a protein that interacts with the branchpoint adenosine.

SR proteins are required for formation of A complex in AT-AC splicing. The same SR proteins involved in splicing of the major introns are also active in splicing of AT-AC introns, though, as in the major pathway, there is substrate specificity.

R-HSA-75081 (Reactome) The U4atac/U6atac enters the spliceosome and U6atac snRNA forms base pairing interactions with the 5' ss and also forms base pairing interactions with U12 and U4atac is partially displaced. U5 snRNP, the only snRNP common to both the major and minor splicing pathways, also joins the spliceosome to form the B complex and interacts with nucleotides within the 3' end of the exon flanking the 5' ss.
R-HSA-75082 (Reactome) At the beginning of this reaction, 1 molecule of 'ATAC C Complex' is present. At the end of this reaction, 1 molecule of 'ATAC C Complex with lariat containing 5'-end cleaved mRNA' is present.

This reaction takes place in the 'nucleus'.

R-HSA-75083 (Reactome) At the beginning of this reaction, 1 molecule of 'ATAC C Complex with lariat containing 5'-end cleaved mRNA' is present. At the end of this reaction, 1 molecule of 'U6 ATAC snRNP', 1 molecule of 'post exon ligation complex', 1 molecule of 'U12 snRNP', 1 molecule of 'U11 snRNP', and 1 molecule of 'U5 snRNP' are present.

This reaction takes place in the 'nucleus'.

R-HSA-75096 (Reactome) At the beginning of this reaction, 1 molecule of 'TAP:3'-polyadenylated, capped mRNA complex' is present. At the end of this reaction, 1 molecule of 'SRp55', 1 molecule of 'U2AF 65 kDa subunit', 1 molecule of 'SR9 / SRp30', 1 molecule of 'hTra2', 1 molecule of 'hPrp16', 1 molecule of 'SR 11/ p54', 1 molecule of 'hPrp22', 1 molecule of 'SRp40', 1 molecule of 'hPrp17', 1 molecule of 'SF2/ASF/SFRS1', 1 molecule of 'hSLU7', 1 molecule of 'Export Receptor bound mature mRNA Complex', 1 molecule of 'U2AF 35 kDa subunit', 1 molecule of 'SR2 / SC35', 1 molecule of 'hPrp43', 1 molecule of 'SRp20', 1 molecule of 'SR7/ 9G8 protein', 1 molecule of 'hPrp18', and 1 molecule of 'SR4 / SRp75' are present.

This reaction takes place in the 'nucleoplasm'.

R-HSA-75097 (Reactome) In this reaction, 1 molecule of 'Export Receptor bound mature mRNA Complex' is translocated from nucleoplasm to cytosol.

This reaction takes place in the 'nuclear envelope'.

R-HSA-75098 (Reactome) At the beginning of this reaction, 1 molecule of and 1 molecule of 'Export Receptor bound mature mRNA Complex' are present. At the end of this reaction, 1 molecule of 'THOC4(Aly/Ref)', 1 molecule of 'Mature mRNP Complex', 1 molecule of 'SRm160', and 1 molecule of 'TAP' are present.

This reaction takes place in the 'cytoplasm'.

R-HSA-77587 (Reactome) Histone mRNAs are exported by a mechanism that requires TAP, the key factor requires for transport of polyadenylated mRNAs. How TAP is recruited to the histone mRNAs is not known, but it is clear that transport can occur in the absence of either the stemloop or of SLBP. The stemloop and SLBP enhance the rate of transport of histone mRNAs in Xenopus oocytes, but are not essential for transport
R-HSA-77594 (Reactome) The polyadenylated, capped transcript and TAP dock at the nucleoplasmic side of the NPC. The Cap Binding Complex (CBC) and CPSF complexes are released back into the nucleoplasm.
R-HSA-8849157 (Reactome) The THO subcomplex of the TREX complex initially interacts with the serine-2,5 phosphorylated C-terminal domain of RNA polymerase II (Strasser et al. 2002, Inferred from yeast in Meinel et al. 2013) then with CBP80 of the cap binding complex (Cheng et al. 2006, Dufu et al. 2010, Chi et al. 2013). A TREX complex binds spliced mRNA near the cap during transcription (Cheng et al. 2006). Recruitment is dependent on splicing of the mRNA (Masuda et al. 2005). THO/TREX is required for efficient mRNP biogenesis and export (reviewed in Luna et al 2012). In yeast, components of the THO/TREX complex also affect transcription and 3' processing of mRNA, (Rondon et al. 2003, Rougemaille et al. 2008, Johnson et al. 2011, reviewed in Katahira 2015), however the human TREX complex does not appear to affect transcription (Masuda et al. 2005). The AREX complex, which contains DDX39A (UHR49) rather than DDX39B (UAP56) appears to perform the same function as TREX in mRNA export, but acts on a different subset of mRNAs (Yamazaki et al. 2010).
RBM5R-HSA-72107 (Reactome)
RBMXArrowR-HSA-72160 (Reactome)
RBMXR-HSA-72103 (Reactome)
RNA

polymerase II

(phosphorylated):TFIIF complex
ArrowR-HSA-72160 (Reactome)
RNPS1R-HSA-72107 (Reactome)
SARNPArrowR-HSA-75096 (Reactome)
SARNPR-HSA-8849157 (Reactome)
SART1ArrowR-HSA-72130 (Reactome)
SNRNP27ArrowR-HSA-72130 (Reactome)
SRRM1R-HSA-72107 (Reactome)
SRRTR-HSA-72107 (Reactome)
SRSF11ArrowR-HSA-75096 (Reactome)
SRSF11R-HSA-72124 (Reactome)
SRSF1ArrowR-HSA-75096 (Reactome)
SRSF1R-HSA-72107 (Reactome)
SRSF1R-HSA-75080 (Reactome)
SRSF2ArrowR-HSA-75096 (Reactome)
SRSF2R-HSA-72107 (Reactome)
SRSF2R-HSA-75080 (Reactome)
SRSF3ArrowR-HSA-75096 (Reactome)
SRSF3R-HSA-72107 (Reactome)
SRSF4ArrowR-HSA-75096 (Reactome)
SRSF4R-HSA-72124 (Reactome)
SRSF5ArrowR-HSA-75096 (Reactome)
SRSF5R-HSA-72107 (Reactome)
SRSF6ArrowR-HSA-75096 (Reactome)
SRSF6R-HSA-72107 (Reactome)
SRSF6R-HSA-75080 (Reactome)
SRSF7ArrowR-HSA-75096 (Reactome)
SRSF7R-HSA-72107 (Reactome)
SRSF7R-HSA-75080 (Reactome)
SRSF9ArrowR-HSA-75096 (Reactome)
SRSF9R-HSA-72107 (Reactome)
SUGP1R-HSA-72107 (Reactome)
Spliced mRNA:CBC:EJC:TREXArrowR-HSA-8849157 (Reactome)
Spliced mRNA:CBC:EJC:TREXR-HSA-72180 (Reactome)
Spliced mRNPArrowR-HSA-72160 (Reactome)
Spliced mRNPR-HSA-8849157 (Reactome)
Spliceosomal

Intermediate C

(Bact) Complex
ArrowR-HSA-72130 (Reactome)
Spliceosomal

Intermediate C

(Bact) Complex
R-HSA-72139 (Reactome)
Spliceosomal

Intermediate C

(Bact) Complex
mim-catalysisR-HSA-72139 (Reactome)
Spliceosomal A ComplexArrowR-HSA-72124 (Reactome)
Spliceosomal A ComplexR-HSA-72127 (Reactome)
Spliceosomal Active C (B*) ComplexArrowR-HSA-72139 (Reactome)
Spliceosomal Active C (B*) ComplexR-HSA-72143 (Reactome)
Spliceosomal B ComplexArrowR-HSA-72127 (Reactome)
Spliceosomal B ComplexR-HSA-72130 (Reactome)
Spliceosomal E ComplexArrowR-HSA-72107 (Reactome)
Spliceosomal E ComplexR-HSA-72124 (Reactome)
Spliceosomal active

C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC

complex
ArrowR-HSA-72143 (Reactome)
Spliceosomal active

C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC

complex
R-HSA-156661 (Reactome)
THO complexArrowR-HSA-75096 (Reactome)
THO complexR-HSA-8849157 (Reactome)
TRA2BR-HSA-72143 (Reactome)
U1 snRNPArrowR-HSA-72130 (Reactome)
U1 snRNPR-HSA-72107 (Reactome)
U11 snRNPArrowR-HSA-75083 (Reactome)
U11 snRNPR-HSA-75080 (Reactome)
U12 snRNPArrowR-HSA-75083 (Reactome)
U12 snRNPR-HSA-75080 (Reactome)
U2 snRNPR-HSA-72124 (Reactome)
U2AF1ArrowR-HSA-75096 (Reactome)
U2AF1R-HSA-72107 (Reactome)
U2AF2ArrowR-HSA-75096 (Reactome)
U2AF2R-HSA-72107 (Reactome)
U4 ATAC snRNPArrowR-HSA-75079 (Reactome)
U4 ATAC:U5:U6 ATAC ComplexR-HSA-75081 (Reactome)
U4 snRNPArrowR-HSA-72130 (Reactome)
U4:U5:U6 tri-snRNP complexR-HSA-72127 (Reactome)
U5 snRNPArrowR-HSA-75083 (Reactome)
U6 ATAC snRNPArrowR-HSA-75083 (Reactome)
UPF3BR-HSA-72143 (Reactome)
USP39ArrowR-HSA-72130 (Reactome)
YBX1R-HSA-72107 (Reactome)
ZC3H11AArrowR-HSA-75096 (Reactome)
ZC3H11AR-HSA-8849157 (Reactome)
capped

pre-mRNA:CBC:RNA Pol II (phosphorylated)

complex
R-HSA-72095 (Reactome)
capped, methylated

pre-mRNA:CBC

Complex
ArrowR-HSA-72095 (Reactome)
capped, methylated

pre-mRNA:CBC

Complex
R-HSA-72103 (Reactome)
capped, methylated

pre-mRNA:CBC

Complex
R-HSA-75080 (Reactome)
capped, methylated

pre-mRNP:CBC

complex
ArrowR-HSA-72103 (Reactome)
capped, methylated

pre-mRNP:CBC

complex
R-HSA-72107 (Reactome)
hSLU7ArrowR-HSA-75096 (Reactome)
hSLU7R-HSA-72160 (Reactome)
intron-containing complexArrowR-HSA-72160 (Reactome)
mRNA (N6-adenosine)-methyltransferasemim-catalysisR-HSA-72095 (Reactome)
mRNA 3'-end cleavage factormim-catalysisR-HSA-72180 (Reactome)
mRNA:CBC:EJC:POLDIP3ArrowR-HSA-75098 (Reactome)
polyadenylated,

capped

mRNA:CBC:EJC:TREX:SRSF proteins
ArrowR-HSA-72185 (Reactome)
polyadenylated,

capped

mRNA:CBC:EJC:TREX:SRSF proteins
R-HSA-159101 (Reactome)
polyadenylated,

capped

mRNA:CBC:EJC:TREX:SRSF proteins
mim-catalysisR-HSA-159101 (Reactome)
post exon ligation complexArrowR-HSA-75083 (Reactome)
pre-EJC:Spliceosomal C:pre-mRNP:CBCArrowR-HSA-156661 (Reactome)
pre-EJC:Spliceosomal C:pre-mRNP:CBCR-HSA-72160 (Reactome)
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