Canonical and non-canonical Notch signaling (Homo sapiens)

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1unknownSignal sending cellSignal receiving cellCell adhesionLigandsNOTCH intra-cellular domainNOTCH non-canonical targetsCanonical target genesNOTCH extra-cellular domainDNERNICDHEY1NOTCH4RRASPSEN2DLK1MAML2MAML3PSEN1HES1NOTCH1MAML1DLL1DLL4RBPJJAG2IKKaNB3NOTCH3MAGP1DLK2NECDADAM10LEF1NOTCH2MAGP2JAG1DLL3NF-kB pathwayNECDNICDNICDNICDNICDNICDNICD


Description

No description

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Bibliography

  1. Tao J, Chen S, Lee B; ''Alteration of Notch signaling in skeletal development and disease.''; Ann N Y Acad Sci, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
127900view23:15, 10 January 2024Khanspersupdated representation of Notch intracellular domain and Notch xrefs
123396view06:25, 23 July 2022EgonwMade a pathway clickable
116460view10:05, 7 May 2021EweitzModified title
110756view15:31, 2 June 2020EgonwAdded missing @Type annotation
110724view14:37, 29 May 2020EveloFixed unknonw datanodes, we should still look at the fact that NICD is actually a subpeptide
90027view19:36, 8 October 2016AlexanderPicoModified description
89632view22:58, 21 September 2016Khanspersupdating PMID for ref
89631view22:46, 21 September 2016Khanspersadded label for nucleus and adjusted interactions
88837view14:59, 15 August 2016AAR&CoEdited Aesthetics and Added Label
88378view00:44, 2 August 2016AAR&CoOntology Term : 'Notch signaling pathway' added !
88377view00:44, 2 August 2016AAR&CoOntology Term : 'signaling pathway' added !
88376view00:40, 2 August 2016AAR&CoFixed Labels
88375view00:36, 2 August 2016AAR&CoEdited Labels
88372view21:34, 1 August 2016AAR&CoModify Datanode
88371view21:33, 1 August 2016AAR&CoPeriodical save, work in progress
88370view21:25, 1 August 2016AAR&CoModify Datanode
88368view21:14, 1 August 2016AAR&CoModify Datanode
88215view17:59, 31 July 2016AAR&CoModify Datanode
88214view17:53, 31 July 2016AAR&CoModify Datanode
87102view17:20, 18 July 2016AAR&CoFixed Unconnected Lines
86823view23:26, 11 July 2016AAR&CoModified description
86822view23:25, 11 July 2016AAR&CoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADAM10GeneProductENSG00000137845 (Ensembl)
DLK1GeneProductENSG00000185559 (Ensembl)
DLK2GeneProductENSG00000171462 (Ensembl)
DLL1GeneProductENSG00000198719 (Ensembl)
DLL3GeneProductENSG00000090932 (Ensembl)
DLL4GeneProductENSG00000128917 (Ensembl)
DNERGeneProductENSG00000187957 (Ensembl)
HES1GeneProductENSG00000114315 (Ensembl)
HEY1GeneProductENSG00000164683 (Ensembl)
IKKaGeneProductENSG00000213341 (Ensembl)
JAG1GeneProductENSG00000101384 (Ensembl)
JAG2GeneProductENSG00000184916 (Ensembl)
LEF1GeneProductENSG00000138795 (Ensembl)
MAGP1GeneProductENSG00000140259 (Ensembl)
MAGP2 GeneProductENSG00000117122 (Ensembl)
MAML1GeneProductENSG00000161021 (Ensembl)
MAML2GeneProductENSG00000184384 (Ensembl)
MAML3GeneProductENSG00000196782 (Ensembl)
NB3GeneProductENSG00000134115 (Ensembl)
NECDProteinIPR000800 (InterPro)
NF-kB pathwayPathwayhsa04064 (KEGG Pathway)
NICDIPR000800 (InterPro)
NOTCH1GeneProductENSG00000148400 (Ensembl)
NOTCH2GeneProductENSG00000134250 (Ensembl)
NOTCH3GeneProductENSG00000074181 (Ensembl)
NOTCH4GeneProductENSG00000204301 (Ensembl)
PSEN1GeneProductENSG00000080815 (Ensembl)
PSEN2GeneProductENSG00000143801 (Ensembl)
RBPJGeneProductENSG00000168214 (Ensembl)
RRASGeneProductENSG00000126458 (Ensembl)

Annotated Interactions

No annotated interactions

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