Physico-chemical features and toxicity-associated pathways (Homo sapiens)

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1Cellular targetsAmyotrophic lateral sclerosis (ALS)ScaffoldReactive oxygen speciesDisturbance of mitochondrial respirationActin polymerisationWnt signaling pathwayRegulation of Actin cytoskeletonH2O2Long-term depressionNOONOO-Focal adhesionCell cycleCa2+NODegradationAdhesion migrationPancreatic cancerCa2+DNACell cycleOHErbB singaling pathwayReceptor ubiquiltylationO2H2OSTAT5MEKDVL1p21FN1B-cateninRasMLCPP2AARP3AXIN1TMSB4MLCPSOS1frizzledWNT16MAPK/ERKGluRAPCJNKKTGFANCKSOD1NOS1RHOANEFHErbB-1ActinRasSrcPAKROCK2ProfilinPLCGFAKELKArgininePI3KMYCNEFLDAAM1CBLErbB-2CAMKPKB/AKTErbB-4GRB2glutamatep27GPX1JNKShc1GSK3BARP2NEFMWNT11JUNMLCKNOS1SOD1SOD1


Description

Genes that were found to be up regulated have been marked red and genes that were found to be down regulated have been marked blue. These 3 pathways demonstrate close links between pathways associated with chemical hits and pathways associated with toxicity. The pathways associated with chemical hits (Wnt signaling, long-term depression, and ErbB signaling pathways) and the pathways associated with toxicity (focal adhesion, ALS, and pancreatic Cancer respectively) have been shown to have possible links through shared genes between the two pathways. The mechanisms of action presented by these links were only implied by the toxicity pathways.

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Bibliography

  1. Antczak P, Ortega F, Chipman JK, Falciani F; ''Mapping drug physico-chemical features to pathway activity reveals molecular networks linked to toxicity outcome.''; PLoS One, 2010 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
140465view04:45, 27 August 2025EgonwMore unicode
140022view18:53, 19 July 2025EgonwCalcium ion with unicode
137962view20:56, 10 March 2025KhanspersModified description
123395view06:24, 23 July 2022EgonwMade a pathway clickable
117651view11:45, 22 May 2021EweitzModified title
106306view17:45, 20 August 2019KhanspersModified description
106167view12:06, 16 August 2019MaintBotHMDB identifier normalization
105537view06:05, 9 August 2019KhanspersModified description
96435view07:49, 15 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
90113view21:26, 13 October 2016Khanspersoverhaul
90112view20:38, 13 October 2016KhanspersModified title
88751view18:36, 14 August 2016AAR&CoFixed Unonnected Line
88750view18:34, 14 August 2016AAR&CoOntology Term : 'pancreatic cancer' added !
88749view18:33, 14 August 2016AAR&CoOntology Term : 'amyotrophic lateral sclerosis disease pathway' added !
88748view18:32, 14 August 2016AAR&CoModified title
88535view00:46, 11 August 2016AAR&CoOntology Term : 'signaling pathway' added !
88530view00:26, 11 August 2016AAR&CoPeriodical save, work in progress
88528view00:19, 11 August 2016AAR&CoModify Datanode
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88488view22:32, 10 August 2016AAR&CoModified description
88487view22:28, 10 August 2016AAR&CoModified description
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87131view18:49, 18 July 2016AAR&CoFixed Unconnected Lines
86140view13:23, 1 July 2016AAR&CoModified description
86139view13:23, 1 July 2016AAR&CoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
APCMetaboliteHMDB60661 (HMDB)
ARP2GeneProductENSG00000138071 (Ensembl)
ARP3GeneProductENSG00000115091 (Ensembl)
AXIN1GeneProductENSG00000103126 (Ensembl)
ActinProteinIPR004000 (InterPro)
ArginineMetabolite29016 (ChEBI)
B-cateninGeneProductENSG00000168036 (Ensembl)
CAMKGeneProductENSG00000134072 (Ensembl)
CBLGeneProductENSG00000110395 (Ensembl)
DAAM1GeneProductENSG00000100592 (Ensembl) assists in formation of Dvl-Rho complex
DVL1GeneProductENSG00000107404 (Ensembl)
ELKGeneProductENSG00000126767 (Ensembl)
ErbB-1GeneProductENSG00000146648 (Ensembl)
ErbB-2GeneProductENSG00000141736 (Ensembl)
ErbB-4GeneProductENSG00000178568 (Ensembl)
FAKGeneProductENSG00000169398 (Ensembl)
  • PRK2
  • Focal adhesion kinase
FN1GeneProductENSG00000115414 (Ensembl)
GPX1GeneProductENSG00000233276 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl)
GluRGeneProductGeneral glutamate receptor
JNKGeneProductENSG00000107643 (Ensembl)
JNKK GeneProductENSG00000065559 (Ensembl)
JUNGeneProductENSG00000177606 (Ensembl)
MAPK/ERKGeneProductENSG00000100030 (Ensembl)
MEKGeneProductENSG00000169032 (Ensembl)
MLCGeneProductENSG00000168530 (Ensembl)
MLCKGeneProductENSG00000065534 (Ensembl) myosin light chain kinase
MLCPGeneProductENSG00000228868 (Ensembl) myosin-light chain phosphatase
MYCGeneProductENSG00000136997 (Ensembl)
NCKGeneProductENSG00000158092 (Ensembl)
NEFHGeneProductENSG00000100285 (Ensembl)
NEFLGeneProductENSG00000277586 (Ensembl)
NEFMGeneProductENSG00000104722 (Ensembl)
NOS1GeneProductENSG00000089250 (Ensembl)
PAKGeneProductENSG00000149269 (Ensembl)
PI3KGeneProductENSG00000105851 (Ensembl)
PKB/AKTGeneProductENSG00000142208 (Ensembl)
PLCGGeneProductENSG00000124181 (Ensembl)
PP2AGeneProductENSG00000113575 (Ensembl)
ProfilinProteinIPR002097 (InterPro)
RHOAGeneProductENSG00000067560 (Ensembl)
ROCK2GeneProductENSG00000134318 (Ensembl)
RasGeneProductENSG00000132155 (Ensembl)
RasProteinIPR020849 (InterPro)
SOD1GeneProductENSG00000142168 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
STAT5GeneProductENSG00000126561 (Ensembl)
Shc1 GeneProductENSG00000160691 (Ensembl)
SrcGeneProductENSG00000197122 (Ensembl)
TGFAGeneProductENSG00000163235 (Ensembl)
TMSB4GeneProductK05764 (KEGG Genes)
WNT11GeneProductENSG00000085741 (Ensembl)
WNT16GeneProductENSG00000002745 (Ensembl)
frizzledGeneProductENSG00000111432 (Ensembl)
glutamateMetabolite29988 (ChEBI)
p21GeneProductENSG00000124762 (Ensembl)
p27GeneProductENSG00000111276 (Ensembl)

Annotated Interactions

No annotated interactions

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